HANCOCK JOHN INSTITUTIONAL SERIES TRUST
PRE 14A, 1999-09-13
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As filed with the Securities and Exchange Commission on September 13, 1999.

                                  SCHEDULE 14A
                                 (RULE 14A-101)

                    INFORMATION REQUIRED IN PROXY STATEMENT

                              FILE NUMBER 811-0560

                            SCHEDULE 14A INFORMATION

                PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE
               SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. __)

[X]  Filed by the Registrant

[ ]  Filed by a Party other than the Registrant

Check the appropriate box:

[X]  Preliminary Proxy Statement

[ ]  Definitive Proxy Statement

[ ]  Definitive Additional Materials

[ ]  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                     JOHN HANCOCK INSTITUTIONAL SERIES TRUST
                (Name of Registrant as Specified in Its Charter)

                     JOHN HANCOCK INSTITUTIONAL SERIES TRUST
                   (Name of Person(s) Filing Proxy Statement)

Payment of filing fee (check the appropriate box):

[ ] $125 per Exchange Act Rules 0-11(c) (1) (ii), 14a-6 (i) (1), or
    14a-6 (i) (2) or Item 22(a) (2) or schedule 14A (sent by wire transmission).

[ ] Fee paid previously with preliminary materials.

[X] No fee required.


<PAGE>

[LOGO] JOHN HANCOCK FUNDS
       A Global Investment Management Firm


                                                                 October 5, 1999

Dear Shareholder:

I am  writing  to ask  for  your  vote  on  important  matters  concerning  your
investment in the John Hancock International Equity Fund.

As you know,  John  Hancock  Advisers,  Inc.  serves as your  fund's  investment
adviser.  John Hancock Advisers  International Limited serves as a subadviser to
your fund,  providing the fund with investment  advice. To provide the fund with
additional international advisory expertise, your fund's Trustees are asking you
to  approve  a  new  subadvisory   contract  between  the  adviser  and  Indocam
International Investment Services.

Your fund's Trustees are also asking you to amend investment  restrictions  that
limit  your  fund's   abilities  on  borrowing  and  lending.   Updating   these
restrictions  will give your fund the  flexibility  of being able to borrow from
other funds in the John Hancock family, rather than from banks.

No Cost to Your Fund or Change in Investment Objective

Though these proposals  require your vote, please be assured that your fund will
not bear the cost for  either  the voting  process  or making  the  changes.  In
addition,  these  proposals  do not in any way  signal a change  in your  fund's
investment  objective.  Your fund's  portfolio  management team will continue to
seek long-term  growth of capital by investing  primarily in stocks of companies
outside the United States.

These proposals have been unanimously approved by your fund's Board of Trustees,
who  believe  they  will  benefit  you and your  fellow  shareholders.  They are
detailed in the enclosed  proxy  statement  and  summarized in the questions and
answers  on the  following  pages.  I suggest  you read both  thoroughly  before
voting.

Your Vote Makes a Difference!

No matter what size your investment may be, your vote is critical. I urge you to
review the  enclosed  materials  and to  complete,  sign and return the enclosed
proxy ballot to us  immediately.  Your prompt  response will help avoid the need
for additional mailings.  For your convenience,  we have provided a postage-paid
envelope.

If you have any questions or need  additional  information,  please contact your
investment   professional  or  call  your  Customer  Service  Representative  at
1-800-225-5291, Monday through Friday between 8:00 A.M. and 8:00 P.M.
Eastern Time. I thank you for your prompt vote on this matter.

                                    Sincerely,


                                    /s/Edward J. Boudreau, Jr.
                                    --------------------------
                                    Edward J. Boudreau, Jr.
                                    Chairman and CEO


<PAGE>


Q: Who is Indocam International Investment Services?

A: Indocam International Investment Services (IIIS) is a wholly owned subsidiary
of Indocam,  the asset management affiliate of Credit Agricole, a French banking
group.  Indocam is an indirect subsidiary of certain holding companies of Caisse
Nationale de Credit Agricole, one of the largest financial and industrial groups
in Europe.  As of December 31, 1998,  the Indocam group had over $150 billion in
assets worldwide.

Indocam is a global investment firm, with a presence in financial centers around
the world, including Paris, London,  Frankfurt, Hong Kong, Tokyo, Singapore, New
York and Boston. Based in Paris, Indocam is an asset management firm maintaining
established relationships with institutional, corporate and individual investors
around the world.

In  addition  to  other  management   responsibilities,   Indocam  International
Investment  Services serves as a subadviser to the John Hancock  European Equity
Fund.  Indocam Asia  Advisers  Limited,  an affiliate of IIIS and  subsidiary of
Indocam, serves as a subadviser to the John Hancock Pacific Basin Equities Fund.

Q: How can the addition of Indocam International Investment Services to the
   portfolio management team benefit me?

A: Upon approval of the proposed new subadvisory contract, the fund's day-to-day
portfolio management  responsibilities  will be assumed by Indocam International
Investment  Services.  Based in Paris, a team of portfolio managers at IIIS will
be able to draw on the vast investment  experience of strategists,  analysts and
portfolio  managers in Indocam's  offices around the world. Your fund's Trustees
believe  that the  investment  advice  and  local  insight  IIIS will be able to
provide into European and other  international  financial markets should benefit
you and your fund.

Q: Does this change in portfolio management signify a change in the fund's
   investment objective and strategy?

A:  No,  these  proposals  do not in any way  signal  a  change  in your  fund's
investment  objective or  strategy.  Your fund will  continue to seek  long-term
growth of capital by  investing  primarily in  diversified  portfolio of foreign
stocks.  To pursue this objective,  your fund's  portfolio  management team will
continue to identify investment  opportunities by focusing on country allocation
and stock selection.

<PAGE>


Q: Will the addition of Indocam International Investment Services to the
   portfolio management team cause in increase in my fund's management fee?

A: No, there will be no change to your fund's management fee.

Q: Why are the fund's investment restrictions on borrowing money and making
   loans being amended?

A: Updating these  restrictions  will provide your fund with the  flexibility to
make loans to and borrow from other John Hancock mutual funds,  rather than from
banks.  Your fund will likely  receive more favorable loan terms and incur fewer
transaction costs through interfund borrowing.  Your fund also will benefit from
the  flexibility  of being able to invest  excess  cash by lending to other John
Hancock mutual funds.  These updated policies will be consistent with other John
Hancock mutual funds.

Q:  How do I vote?


A: Most  shareholders  typically vote by  completing,  signing and returning the
enclosed proxy card using the postage-paid  envelope provided.  If you prefer to
vote in person, you are cordially invited to attend a meeting of shareholders of
your  fund,  which  will be held at 9:00  A.M.  on  December  1, 1999 at our 101
Huntington Avenue  headquarters in Boston,  Massachusetts.  If you vote now, you
will help avoid further solicitations.



<PAGE>




                     JOHN HANCOCK INTERNATIONAL EQUITY FUND
              (a series of John Hancock Institutional Series Trust)
                              101 Huntington Avenue
                                Boston, MA 02199


                    NOTICE OF SPECIAL MEETING OF SHAREHOLDERS
                           TO BE HELD DECEMBER 1, 1999


This is the formal agenda for your fund's special meeting. It tells you what
matters will be voted on and the time and place of the meeting, in case you want
to attend in person.

To the shareholders of John Hancock International Equity Fund:

A special meeting of shareholders of your fund will be held at 101 Huntington
Avenue, Boston, Massachusetts on Wednesday, December 1, 1999 at 9:00 a.m.,
Eastern time, to consider the following:

1.           A proposal to approve a new sub-investment management contract
             between John Hancock Advisers, Inc. and Indocam International
             Investment Services. Your board of trustees recommends that you
             vote FOR this proposal.

2.(a) - (b)  Proposals to amend the fund's investment restrictions on
             borrowing money and making loans. Your board of trustees recommends
             that you vote FOR this proposal.

3.           Any other business that may properly come before the meeting.

Shareholders of record as of the close of business on September 14, 1999 are
entitled to vote at the meeting and any related follow-up meetings.

Whether or not you expect to attend the meeting, please complete and return the
enclosed proxy card. Please take a few minutes to vote now.

                                    By order of the board of trustees,

                                    /s/Susan S. Newton
                                    ------------------
                                    Susan S. Newton
                                    Secretary


October 5, 1999


                                       1
<PAGE>



                               PROXY STATEMENT OF
                     JOHN HANCOCK INTERNATIONAL EQUITY FUND
              (a series of John Hancock Institutional Series Trust)

This proxy statement contains the information you should know before voting on
the proposals as summarized below.

Your fund will furnish without charge a copy of its most recent annual report to
any shareholder upon request. Shareholders who want to obtain a copy of the
fund's annual report should direct all written requests to the attention of the
fund, 101 Huntington Avenue, Boston, Massachusetts 02199 or call John Hancock
Funds at 1-800-225-5291.

                                  INTRODUCTION

This proxy statement is being used by the board of trustees of your fund to
solicit proxies to be voted at a special meeting of shareholders of your fund.
This meeting will be held at the principal executive offices of the fund, 101
Huntington Avenue, Boston, Massachusetts on Wednesday, December 1, 1999 at 9:00
a.m., Eastern time. The purpose of the meeting is to consider:

1.           A proposal to approve a new sub-investment management contract
             between John Hancock Advisers, Inc. and Indocam International
             Investment Services.

2. (a)-(b)   Proposals to amend the fund's investment restrictions on
             borrowing money and making loans.

3.           Any other business that may properly come before the meeting.

This proxy statement and the proxy card are being mailed to fund shareholders on
or about October 5, 1999.

Who is Eligible to Vote?

Shareholders of record on September 14, 1999 are entitled to attend and vote on
each proposal at the meeting or any adjourned meeting. Each share is entitled to
one vote. Shares represented by properly executed proxies, unless revoked before
or at the meeting, will be voted according to shareholder instructions. If you
sign a proxy, but do not fill in a vote, your shares will be voted "for" the
proposals. If any other business comes before the meeting, your shares will be
voted at the discretion of the persons named as proxies.


                                       2
<PAGE>


                                   PROPOSAL 1

                                APPROVAL OF A NEW
                       SUB-INVESTMENT MANAGEMENT CONTRACT

John Hancock Advisers, Inc. (the "adviser") serves as your fund's investment
adviser and is responsible for providing the fund with a continuous investment
program under an investment management contract dated March 30, 1995 (the
"management contract"). The management contract was approved by the shareholders
of the fund on March 30, 1995.

The adviser hired John Hancock Advisers International Limited ("JHAI") to serve
as a sub-investment adviser to the fund under a sub-investment management
contract dated March 30, 1995 (the "existing contract"). JHAI, subject to the
review of the fund's trustees and the overall supervision of the adviser,
provides the fund with investment advice. The existing contract was approved by
the shareholders of the fund on March 30, 1995.

At a meeting of your fund's trustees held on September 14, 1999, the trustees,
including all of the independent trustees (those who are not "interested
persons" as defined in the Investment Company Act of 1940, as amended (the "1940
Act")), unanimously approved and voted to recommend that shareholders of your
fund approve a new subadvisory contract (the "proposed contract") between the
adviser and Indocam International Investment Services ("IIIS"). The form of
proposed contract is attached to this proxy statement as Exhibit A.

Pursuant to the proposed contract, IIIS will serve as a co-subadviser to the
fund, together with JHAI, in order to provide the fund with additional
international advisory expertise. IIIS, with its principal office in Paris,
France, will be able to provide the fund with investment advice and local
insight into European and other international financial markets.

Approval of the proposed contract will not result in any increase in fees
payable by the fund. As with JHAI under the existing contract, the adviser will
be solely responsible for paying the subadvisory fee to IIIS under the proposed
contract.

Under the proposed contract, IIIS will provide the fund with advice and
recommendations regarding the fund's investments. IIIS will also provide the
fund on a continuous basis with economic, financial and political information,
research and assistance concerning international markets.

Indocam International Investment Services

IIIS is organized under the laws of France and is a wholly owned subsidiary of
Indocam, the asset management affiliate of Credit Agricole, a French banking
group. Indocam is an indirect subsidiary of certain holding companies of Caisse
Nationale de Credit Agricole ("CNCA"), one of the largest financial and
industrial groups in Europe. As of December 31, 1998, the Indocam group had over
$150 billion in assets worldwide.

                                       3
<PAGE>


IIIS currently serves as investment adviser to The France Growth Fund, Inc., a
registered closed-end investment company. In addition, IIIS serves as subadviser
to three open-end investment companies (mutual funds): BNY Hamilton
International Equity Fund, Victory International Growth Fund and John Hancock
European Equity Fund. The asset size and the fee rate payable to IIIS for each
fund subadvised by them with a similar investment objective are as follows:

- --------------------------------------------------------------------------------
Fund                            Fund Assets*              Fee Rate
- --------------------------------------------------------------------------------

BNY Hamilton International      $7.7 million              0.425%
Equity Fund                                               (Sub-investment
                                                          management fee)
Victory International Growth    $133 million              0.550%
Fund                                                      (Sub-investment
                                                          management fee)
*As of June 30, 1999.

Although IIIS operates on a fully independent basis and makes its own investment
decisions in rendering investment advice, it has access to the extensive
research and other resources of CNCA's group of affiliated entities. The
investment personnel of IIIS also are employed by and act as investment
personnel for Indocam and/or Indocam Hong Kong Limited, an affiliate of IIIS
that serves as adviser to certain Asian country funds. The address of IIIS is 90
Boulevard Pasteur, Paris, France 75015.

The principal executive officer and the directors of IIIS are listed below,
along with their principal occupations.

- --------------------------------------------------------------------------------
Name*                                    Principal Occupation
- --------------------------------------------------------------------------------
Jean-Claude Kaltenbach                   Chairman and Chief Executive Officer
Principal Executive Officer,             of IIIS.
Chairman
- --------------------------------------------------------------------------------
Ian Gerald McEvatt                       Managing Director and Chief Investment
Director                                 Officer of Indocam Hong Kong Ltd.
- --------------------------------------------------------------------------------
Claude Rene Doumic                       Chairman of Societe de Port de Tanger
Director                                 (closed-end fund).
- --------------------------------------------------------------------------------
Didier Guyot de la Pommeraye             International Development for Indosuez
Director                                 Asset Management.
- --------------------------------------------------------------------------------
Charles Denis Jules Vergnot              Chairman of Danubexsa.
Director
- --------------------------------------------------------------------------------
Eric Harrison Jostrom                    Chief Executive Officer and Chief
Director                                 Investment Officer of Constitution
                                         Management Company, Inc.
- --------------------------------------------------------------------------------
* The business address of each person listed is 90 Boulevard Pasteur, Paris,
France 75015.


                                       4
<PAGE>

The Adviser

The adviser is a wholly owned subsidiary of The Berkeley Financial Group, Inc.
(the "Berkeley Group"), which is a wholly owned subsidiary of John Hancock
Subsidiaries, Inc., which is a wholly owned subsidiary of John Hancock Mutual
Life Insurance Company (the "Insurance Company"). The adviser currently has more
than $30 billion assets under management in its capacity as investment adviser
to the fund and other funds in the John Hancock Group of Funds as well as other
institutional accounts.

The principal executive officer and the directors of the adviser are listed
below, along with their principal occupations.

- --------------------------------------------------------------------------------
Name and Address                         Principal Occupation
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
Edward J. Boudreau, Jr.                  Chairman and Chief Executive Officer
Principal Executive Officer, Chairman    of the adviser, the Berkeley Group,
101 Huntington Avenue                    John Hancock Funds, Inc., Transamerica
Boston, MA 02199                         Fund Management Company, Sovereign
                                         Asset Management Corporation, NM
                                         Capital Management, Inc., JHAI and
                                         First Signature Bank & Trust Company;
                                         Director of John Hancock Insurance
                                         Agency, Inc. and John Hancock Advisers
                                         International (Ireland) Ltd.
- --------------------------------------------------------------------------------
Foster L. Aborn                          Director of John Hancock Insurance
Director                                 Agency, Inc., John Hancock Capital
John Hancock Place                       Growth Management, Inc., the Berkeley
P.O. Box 111                             Group, the adviser, John Hancock
Boston, MA 02117                         Funds, Inc., Independence Investment
                                         Associates, Inc., the Insurance
                                         Company, John Hancock Capital
                                         Corporation and John Hancock
                                         Subsidiaries, Inc.
- --------------------------------------------------------------------------------
Stephen L. Brown                         Chairman and Chief Executive Officer
Director                                 of the Insurance Company; Director of
John Hancock Place                       John Hancock Insurance Agency, Inc.,
P.O. Box 111                             the Berkeley Group, the adviser, John
Boston, MA 02117                         Hancock Funds, Inc. and John Hancock
                                         Subsidiaries, Inc.
- --------------------------------------------------------------------------------

                                       5
<PAGE>

- --------------------------------------------------------------------------------
David F. D'Alessandro                    Director of John Hancock Insurance
Director                                 Agency, Inc., the adviser, the
John Hancock Place                       Berkeley Group, John Hancock Funds,
P.O. Box 111                             Inc., John Hancock Subsidiaries, Inc.;
Boston, MA 02117                         Chairman and Director, John Hancock
                                         Variable  Life  Insurance  Company  and
                                         John  Hancock   Mutual  Life  Insurance
                                         Company of America; Director, President
                                         and  Chief  Operating  Officer  of  the
                                         Insurance Company.
- --------------------------------------------------------------------------------
John M. DeCiccio                         Director of John Hancock Insurance
Director                                 Agency, Inc., the Berkeley Group, the
John Hancock Place                       adviser, John Hancock Funds, Inc. and
P.O. Box 111                             the Insurance Company.
Boston, MA 02117
- --------------------------------------------------------------------------------
William C. Fletcher                      President and Director of Independence
Director                                 Investment Associates, Inc.; Director
John Hancock Place                       of Independence International
P.O. Box 111                             Associates, Inc., John Hancock
Boston, MA 02117                         Insurance Agency, Inc., the Berkeley
                                         Group, the adviser, John Hancock
                                         Funds, Inc., Hancock Natural Resource
                                         Group, Inc. and Hancock Energy
                                         Resources Management, Inc.; Chairman
                                         and Director of JHM Capital
                                         Management, Inc.
- --------------------------------------------------------------------------------
Maureen R. Ford                          President of broker/dealer
Director                                 distribution of the Insurance Company;
101 Huntington Avenue                    Director of the adviser, the Berkeley
Boston, MA 02199                         Group, John Hancock Funds, Inc.;
                                         President and Director of John Hancock
                                         Insurance Agency, Inc.
- --------------------------------------------------------------------------------
Anne C. Hodsdon                          Director, President and Chief
Director, President, Chief Operating     Operating Officer of the adviser and
Officer and Chief Investment Officer     the Berkeley Group; Director and
101 Huntington Avenue                    Executive Vice President of John
Boston, MA 02199                         Hancock Funds, Inc.; President and
                                         Director  of  NM  Capital   Management,
                                         Inc.,    Sovereign   Asset   Management
                                         Corporation   and   Transamerica   Fund
                                         Management  Company;  Director  of John
                                         Hancock  Insurance  Agency,  Inc., John
                                         Hancock International (Ireland) Ltd.
                                         and JHAI.
- --------------------------------------------------------------------------------

                                       6
<PAGE>

- --------------------------------------------------------------------------------
David A. King                            Chief Executive Officer, President and
Director                                 Director of John Hancock Signature
John Hancock Place                       Services, Inc.; Chairman of Networking
P.O. Box 111                             Insurance Agency; Vice Chairman of
Boston, MA 02117                         First Signature Bank & Trust; Director
                                         of John Hancock Insurance Agency,
                                         Inc., the adviser, the Berkeley Group
                                         and John Hancock Funds, Inc.; Senior
                                         Vice President of the Insurance
                                         Company.
- --------------------------------------------------------------------------------
Jeanne M. Livermore                      Director of John Hancock Insurance
Director                                 Agency, Inc., the Berkeley Group, the
John Hancock Place                       adviser, John Hancock Funds, Inc., and
P.O. Box 111                             JHAI; Senior Vice President of the
Boston, MA 02117                         Insurance Company.
- --------------------------------------------------------------------------------
Thomas E. Moloney                        Chief Financial Officer of the
Director                                 Insurance Company; Director of John
John Hancock Place                       Hancock Insurance Agency, Inc., the
P.O. Box 111                             adviser, the Berkeley Group, John
Boston, MA 02117                         Hancock Funds, Inc., John Hancock
                                         Realty   Services   and  John   Hancock
                                         Capital  Corporation;  Chairman of John
                                         Hancock  Property & Casualty;  Director
                                         and  Chief  Financial  Officer  of John
                                         Hancock  Subsidiaries,  Inc.;  Director
                                         and Chairman of John Hancock  Signature
                                         Services, Inc.
- --------------------------------------------------------------------------------
Richard S. Scipione                      General Counsel of the Insurance
Director                                 Company; Director of John Hancock
John Hancock Place                       Insurance Agency, Inc., Sovereign
P.O. Box 111                             Asset Management Corporation, NM
Boston, MA 02117                         Capital Management, Inc., the Berkeley
                                         Group, the adviser, John Hancock
                                         Funds, Inc. and Signator Investors,
                                         Inc.
- --------------------------------------------------------------------------------
Robert H. Watts                          Executive Vice President of Signator
Director                                 Investors, Inc.; Senior Vice President
John Hancock Place                       of the Insurance Company; Director of
P.O. Box 111                             John Hancock Insurance Agency, Inc.,
Boston, MA 02117                         the Berkeley Group, the adviser and
                                         JHAI.
- --------------------------------------------------------------------------------

John Hancock Advisers International Ltd.

JHAI is a wholly owned subsidiary of the adviser and currently manages more than
$400 million in assets.

The principal executive officer and the directors of JHAI are listed below,
along with their principal occupations.

                                       7
<PAGE>


- --------------------------------------------------------------------------------
Name and Address                         Principal Occupation
- --------------------------------------------------------------------------------
Edward J. Boudreau, Jr.                  Chairman and Chief Executive Officer
Chairman                                 of the adviser, the Berkeley Group,
101 Huntington Avenue                    John Hancock Funds, Inc., Transamerica
Boston, MA 02199                         Fund Management Company, Sovereign
                                         Asset Management Corporation, NM
                                         Capital Management, Inc., JHAI and
                                         First Signature Bank & Trust Company;
                                         Director of John Hancock Insurance
                                         Agency, Inc. and John Hancock Advisers
                                         International (Ireland) Ltd.
- --------------------------------------------------------------------------------
John L. Wills                            Managing Director and Director of
Managing Director                        JHAI; Senior Vice President of
Duke's Court, 6th Floor                  adviser; Director of John Hancock
32-36 Duke Street St. James's            Advisers International (Ireland) Ltd.
London SWIY6DF
- --------------------------------------------------------------------------------
Anne C. Hodsdon                          Director, President and Chief
Director                                 Operating Officer of the adviser and
101 Huntington Avenue                    the Berkeley Group; Director and
Boston, MA 02199                         Executive Vice President of John
                                         Hancock  Funds,  Inc.;   President  and
                                         Director of NM Capital Management, Inc,
                                         Sovereign Asset Management  Corporation
                                         and   Transamerica    Fund   Management
                                         Company;   Director  of  John   Hancock
                                         Insurance  Agency,  Inc.,  John Hancock
                                         International (Ireland) Ltd.
                                         and JHAI.
- --------------------------------------------------------------------------------
Jeanne M. Livermore                      Director of John Hancock Insurance
Director                                 Agency, Inc., the Berkeley Group, the
John Hancock Place                       adviser, John Hancock Funds, Inc., and
P.O. Box 111                             JHAI; Senior Vice President of the
Boston, MA 02117                         Insurance Company.
- --------------------------------------------------------------------------------
Robert H. Watts                          Executive Vice President of Signator
Director                                 Investors, Inc.; Senior Vice President
John Hancock Place                       of the Insurance Company; Director of
P.O. Box 111                             John Hancock Insurance Agency, Inc.,
Boston, MA 02117                         the Berkeley Group, the adviser and
                                         JHAI.
- --------------------------------------------------------------------------------

The Proposed and Existing Contracts

The following is a summary of the material terms of the proposed and existing
contracts. In describing the proposed contract, this summary is qualified by
reference to the form of proposed contract attached to this proxy statement as
Exhibit A.

                                       8
<PAGE>


Compensation. The existing contract and the proposed contract (collectively, the
"contracts") provide that JHAI or IIIS, as the case may be, is required to pay
all expenses that it incurs in connection with the performance of its duties
under the contract. The contracts also provide that the adviser, not the fund,
will pay the subadvisory fees.

The proposed contract requires the adviser to pay quarterly to IIIS a
subadvisory fee, which is accrued daily and on an annual basis is equal to 55%
of the gross management fee received by the adviser with respect to the fund's
average daily net assets.

The existing contract requires the adviser to pay JHAI a subadvisory fee, which
is accrued daily, based on a percentage of the gross management fee received by
adviser as follows:

           -------------------------------------------------------
           Average Daily Net Assets               Percent of Gross
                Managed by JHAI                   Management Fees
           -------------------------------------------------------
              First $500 million                        70%
           Amount Over $500 million                     90%

For the fund's fiscal year ended February 28, 1999, the adviser paid JHAI
$53,170 in subadvisory fees.

If the proposed contract is approved by the fund's shareholders, JHAI will
voluntarily limit its subadvisory fee to 0.05% of the fund's average daily net
assets effective December 2, 1999 or such later date as determined by the
officers of the fund.

Term.  If approved by shareholders of the fund, the proposed contract will take
effect as of December 1, 1999 and will remain in effect until December 1, 2001.
Thereafter, the proposed contract will continue in effect from year to year
subject to the annual approval of its continuance as described below under
"Provisions Contained in Both Contracts and in the Management Contract."

Provisions Contained in Both Contracts and in the Management Contract

Limitation of Liability. The management and the subadvisory contracts provide
that the adviser, JHAI and IIIS are not liable for any error of judgment or
mistake of law or for any loss suffered by the fund in connection with the
matters to which the respective contract relates, except a loss resulting from
willful misfeasance, bad faith or gross negligence on the part of the applicable
adviser, JHAI or IIIS in the performance of its duties or from the reckless
disregard of its obligations and duties under the contracts.

Termination, Continuance and Amendment. Except as described above for the
proposed contract, each contract continues from year to year subject to annual
approval of its continuance by a majority of the independent trustees, cast in
person at a meeting called for the purpose of voting on such approval, and
annual approval by either (a) your fund's trustees, or (b) a majority of your
fund's outstanding voting securities, as defined in the 1940 Act. Each contract
may be terminated at any time without penalty on 60 days' written notice by the
trustees, by a vote of a majority of the fund's outstanding voting securities,
or by the adviser, JHAI or IIIS, as the case may be. Each contract terminates
automatically in the event of its assignment or in the event that the adviser
ceases to act as the fund's investment adviser.

                                       9
<PAGE>


Use of Name "John Hancock." Under the management contract and the existing
contract, if the adviser ceases to act as the fund's investment adviser, the
fund (to the extent that it lawfully can) must cease to use the name "John
Hancock International Equity Fund" or any name derived from the name "John
Hancock" or any other name indicating that the fund is advised by or otherwise
associated with the adviser.

The Management Contract

Under the management contract, the adviser, subject to the direction of the
trustees, provides the fund with a continuous investment program for the
management of its assets, consistent with the fund's investment objective and
policies. The adviser furnishes the fund with advice and recommendations
consistent with the investment policies of the fund regarding the purchase,
holding and disposition of portfolio securities. The adviser:

o   advises the fund in connection with policy decisions to be made by the
    trustees;

o   furnishes the fund with research, economic and statistical data in
    connection with the fund's investments and policies;

o   provides day-to-day administration;

o   investigates and conducts relations with issuers of securities to be
    purchased by the fund;

o   provides required reports and recommendations to the trustees and maintains
    the records of the fund;  and o assists the fund in any  negotiations
    relating to the fund's investments with issuers, investment banking firms,
    securities brokers or dealers and other institutions or investors.

The adviser provides the fund with office space, supplies and other facilities
required for the business of the fund. The adviser pays the compensation of all
officers and employees of the fund and pays the expenses of clerical services
related to the administration of the fund. Other than expenses specifically
assumed by the adviser, all expenses incurred in the continuing operation of the
fund are borne by the fund, including fees of the independent trustees and all
fees of lawyers and accountants. The Fund pays an investment management fee to
the adviser approximately equivalent on an annual basis to a stated percentage
of the average daily net assets of the fund as set forth below:

                                       10
<PAGE>


                Net Asset Value                       Annual Rate
                ---------------                       -----------
             First $500 million                           0.90%
             Amount Over $500 million                     0.65%

The adviser has voluntarily agreed to reduce management fees and other expenses
payable in order to limit the fund's total operating expenses to 1.00% of the
fund's average daily net asset. This agreement may not be modified or
discontinued by the adviser at least until July 1, 2000. During the fiscal year
ended February 28, 1999, the adviser did not receive any management fees from
the Fund.

Analysis of Proposal and Review of Trustees

The trustees have determined that the terms of the proposed contract are fair
and reasonable. In approving the proposed contract and recommending its approval
by the shareholders of the fund, the trustees, including the independent
trustees, considered the best interest of the shareholders of the fund and took
into account all factors they deemed relevant.

In evaluating the proposed contract, the trustees carefully reviewed materials
furnished by the adviser relating to IIIS and its affiliates and their
personnel, operations and financial condition. The trustees considered the
extensive international investment management expertise of IIIS as beneficial to
the fund. The trustees also deemed important the favorable history, reputation
and qualification of IIIS' parent company, Credit Agricole, and the level of
resources available to IIIS through Credit Agricole and its subsidiaries in
providing investment subadvisory services to the fund. Additionally, the
trustees considered that JHAI will voluntarily agree to limit its subadvisory
fee to 0.05% of the fund's average daily net assets effective as of December 1,
1999 or such later date as determined by the officers of the fund. Other factors
deemed important by the trustees in making their recommendation are (i) the
possibility of benefits that may be realized by the fund as a result of IIIS
serving as the fund's investment subadviser; and (ii) other factors deemed
relevant by the trustees.

The trustees also considered possible benefits to IIIS under the proposed
contract, including the ability of IIIS (a) to cause the fund to execute
securities transactions with brokers that are affiliated with Credit Agricole,
subject to compliance with the requirements of the 1940 Act and procedures
adopted by, and with the oversight of, the trustees and (b) to obtain soft
dollar brokerage and research services from brokers that are not affiliated with
Credit Agricole who effect securities transactions on behalf of the fund.
Throughout the review process the independent trustees were advised by their
independent legal counsel, who was not counsel to the trust, the adviser, JHAI
or IIIS.

Trustees' Evaluation and Recommendation

The trustees, including all of the independent trustees, by a vote cast at a
meeting held on September 14, 1999 unanimously approved and voted to recommend
to the shareholders of the fund that they adopt the proposed contract. If the
shareholders of the fund approve the proposed contract, the proposed contract
will take effect as of December 1, 1999.

                                       11
<PAGE>


The trustees of your fund recommend that the shareholders of your fund vote
"for" the proposed contract.


                             PROPOSALS 2(a) AND 2(b)

     AMENDMENTS TO THE FUND'S INVESTMENT RESTRICTIONS ON BORROWING MONEY AND
                      MAKING LOANS INVESTMENT RESTRICTIONS

The adviser and your fund's board of trustees recommend that the following
changes be made to your fund's fundamental investment restrictions on borrowing
money and making loans. These changes will provide your fund with the
flexibility to make loans to and borrow from other John Hancock mutual funds. We
are asking you to vote on these changes because the restrictions are fundamental
and may be changed only with shareholder approval. Before any John Hancock
mutual fund can engage in interfund borrowing, it will require an exemptive
order from the Securities and Exchange Commission. Your fund currently does not
have such an order, but would like the flexibility to seek one.

The adviser expects that you will benefit from the proposed changes to your
fund's fundamental investment restrictions. Your fund will benefit from the
flexibility of being able to borrow money from other funds in the John Hancock
family, rather than from banks. In addition, your fund will likely receive more
favorable loan terms and incur fewer transaction costs through interfund
borrowing. Your fund also will benefit from the flexibility of being able to
invest excess cash by making loans to other John Hancock mutual funds. In
addition, the borrowing restriction will be liberalized to the extent permitted
under the 1940 Act, consistent with other John Hancock mutual funds.

Proposed Amendments to Investment Restrictions

The table below sets forth the fund's current fundamental restrictions on
borrowing money and making loans in the left hand column and the proposed
amended restrictions in the right hand column.


                                       12
<PAGE>

<TABLE>
<CAPTION>



                                  Proposal 2(a)

              <S>                     <C>                  <C>
- --------------------------------------------------------------------------------
  Current Fundamental Restriction           Amended Fundamental Restriction
- --------------------------------------------------------------------------------
The Fund may not borrow money, except     The fund may not borrow money, except:
for the following extraordinary or        (i) for temporary or short-term
emergency purposes: (i) from banks for    purposes or for the clearance of
temporary or short-term purposes or for   transactions in amounts not to exceed
the clearance of transactions in          33 1/3% of the value of the fund's
amounts not to exceed 33 1/3% of the      total assets (including the amount
value of the Fund's total assets          borrowed) taken at market value; (ii)
(including the amount borrowed) taken     in connection with the redemption of
at market value; (ii) in connection       fund shares or to finance failed
with the redemption of Fund shares or     settlements of portfolio trades without
to finance failed settlements of          immediately liquidating portfolio
portfolio trades without immediately      securities or other assets; (iii) in
liquidating portfolio securities or       order to fulfill commitments or plans
other assets; (iii) in order to fulfill   to purchase additional securities
commitments or plans to purchase          pending the anticipated sale of other
additional securities pending the         portfolio securities or assets; (iv) in
anticipated sale of other portfolio       connection with entering into reverse
securities or assets; and (iv) in the     repurchase agreements and dollar rolls,
case of Small Capitalization Growth       but only if after each such borrowing
Fund, in connection with entering into    there is asset coverage of at least
reverse repurchase agreements and         300% as defined in the 1940 Act; and
dollar rolls, but only if after each      (v) as otherwise permitted under the
such borrowing there is asset coverage    1940 Act.  The fund may borrow money
of at least 300% as defined in the 1940   from other investment companies managed
Act. A Fund, other than Small             or distributed by the fund's investment
Capitalization Growth Fund, may not       adviser or any affiliate of the
borrow money for the purpose of           investment adviser.  For purposes of
leveraging the Funds' assets.  For        this investment restriction, the
purposes of this investment               deferral of trustees' fees and
restriction, the deferral of Trustees'    transactions in all types of derivative
fees and transactions in short sales,     transactions are not considered to be
futures contracts, options on futures     borrowing.
contracts, securities or indices and
forward commitment transactions shall
not constitute borrowing.
- --------------------------------------------------------------------------------


                                       13
<PAGE>




                                 Proposal 2(b)

- --------------------------------------------------------------------------------
  Current Fundamental Restriction           Amended Fundamental Restriction
- --------------------------------------------------------------------------------
The Fund may not make loans, except       The Fund may not make loans, except
that the Fund (i) may lend portfolio      that the Fund may (i) purchase or hold
securities in accordance with the         debt instruments in accordance with the
Fund's investment policies up to 33       Fund's investment policies, (ii) make
1/3% of the Fund's total assets taken     loans to other investment companies
at market value, (ii) enter into          managed or distributed by the fund's
repurchase agreements, and (iii)          investment adviser or any affiliate of
purchase all or a portion of an issue     the investment adviser, and (iii) make
of debt securities, bank loan             loans of portfolio securities provided
participation interests, bank             that as a result no more than 33 1/3%
certificates of deposit, bankers'         of the Fund's total assets taken at
acceptances, debentures or other          current value would be so loaned.  The
securities, whether or not the purchase   Fund does not, for this purpose,
is made upon the original issuance of     consider the purchase of repurchase
the securities.                           agreements, bank certificates of
                                          deposit, bank loan participation
                                          agreements, bankers' acceptances, a
                                          portion of an issue of publicly
                                          distributed bonds, debentures or other
                                          securities, whether or not the purchase
                                          is made upon the original issuance of
                                          the securities, to be the making of a
                                          loan.
- --------------------------------------------------------------------------------
</TABLE>

Board Evaluation and Recommendation

The trustees believe that the proposed amendments to the fund's investment
restrictions will more clearly reflect current regulatory practice and will
expand the borrowing and lending opportunities available to the fund.
Accordingly, the trustees recommend that you approve the proposals to change the
fund's fundamental investment restrictions described above.

If the required approval of a change to a restriction is not obtained, the
current investment restriction will continue in effect.

The trustees of your fund recommend that the shareholders of your fund vote
"for" the proposal to amend the fund's investment restrictions.


                                       14

<PAGE>


                         VOTING RIGHTS AND REQUIRED VOTE

Each share of your fund is entitled to one vote for each proposal. Approval of
each proposal requires the affirmative vote of a majority of the shares of your
fund outstanding and entitled to vote. For this purpose, a majority of the
outstanding shares of your fund means with respect to each proposal the vote of
the lesser of:

(1)      67% or more of the shares present at the meeting, if the holders of
         more than 50% of the shares of the fund are present or represented by
         proxy,

         or

(2)      more than 50% of the outstanding shares of the fund.

Shares of your fund represented in person or by proxy, including shares which
abstain or do not vote with respect to a proposal, will be counted for purposes
of determining whether there is a quorum at the meeting. Accordingly, an
abstention from voting has the same effect as a vote against a proposal.

However, if a broker or nominee holding shares in "street name" indicates on the
proxy card that it does not have discretionary authority to vote on a proposal,
those shares will not be considered present and entitled to vote on that
proposal. Thus, a "broker non-vote" has no effect on the voting in determining
whether a proposal has been adopted in accordance with clause (1) above, if more
than 50% of the outstanding shares (excluding the "broker non-votes") are
present or represented. However, for purposes of determining whether a proposal
has been adopted in accordance with clause (2) above, a "broker non-vote" has
the same effect as a vote against that proposal because shares represented by a
"broker non-vote" are considered to be outstanding shares.


                       INFORMATION CONCERNING THE MEETING

Solicitation of Proxies

In addition to the mailing of these proxy materials, proxies may be solicited by
telephone, by fax or in person by the trustees, officers and employees of your
fund; by personnel of the adviser, the fund's principal distributor, John
Hancock Funds, Inc., and the fund's transfer agent, John Hancock Signature
Services, Inc., or by broker-dealer firms. Signature Services, together with a
third party solicitation firm, has agreed to provide proxy solicitation services
at a cost of approximately $555, which will be paid by the adviser.

The mailing address of the fund, the adviser and John Hancock Funds is 101
Huntington Avenue, Boston, Massachusetts, 02199.

                                       15
<PAGE>


Revoking Proxies

A shareholder signing and returning a proxy has the power to revoke it at any
time before it is exercised:

o        By filing a written notice of revocation with your fund's transfer
         agent, John Hancock Signature Services, Inc., 1 John Hancock Way, Suite
         1000, Boston, Massachusetts 02217-1000,

o        By returning a duly executed proxy with a later date before the time of
         the meeting, or

o        If a shareholder has executed a proxy but is present at the meeting
         and wants to vote in person, by notifying the secretary of the fund
         (without complying with any formalities) at any time before it is
         voted.

Being present at the meeting alone does not revoke a previously executed and
returned proxy.

Outstanding Shares and Quorum

As of September 14, 1999, _____________ shares of beneficial interest of the
fund were outstanding. Only shareholders of record on September 14, 1999 (record
date) are entitled to notice of and to vote at the meeting. A majority of the
outstanding shares of the fund that are entitled to vote will be considered a
quorum for the transaction of business.

Other Business

The fund's board of trustees knows of no business to be presented for
consideration at the meeting other than the proposal. If other business is
properly brought before the meeting, proxies will be voted according to the best
judgment of the persons named as proxies.

Adjournments

If a quorum is not present in person or by proxy at the time any session of the
meeting is called to order, the persons named as proxies may vote those proxies
that have been received to adjourn the meeting to a later date. If a quorum is
present but there are not sufficient votes in favor of the proposal, the persons
named as proxies may propose one or more adjournments of the meeting to permit
further solicitation of proxies concerning the proposal. Any adjournment will
require the affirmative vote of a majority of the fund's shares at the session
of the meeting to be adjourned. If an adjournment of the meeting is proposed
because there are not sufficient votes in favor of the proposal, the persons
named as proxies will vote those proxies favoring the proposal in favor of
adjournment, and will vote those proxies against the proposal against
adjournment.

                                       16
<PAGE>


Telephone Voting

In addition to soliciting proxies by mail, by fax or in person, the fund may
also arrange to have votes recorded by telephone by officers and employees of
the fund or by personnel of the adviser or transfer agent. The telephone voting
procedure is designed to verify a shareholder's identity, to allow a shareholder
to authorize the voting of shares in accordance with the shareholder's
instructions and to confirm that the voting instructions have been properly
recorded. If these procedures were subject to a successful legal challenge,
these telephone votes would not be counted at the meeting. The fund has not
obtained an opinion of counsel about telephone voting, but is currently not
aware of any challenge.

o    A shareholder  will be called on a recorded line at the telephone number in
     the fund's account  records and will be asked to provide the  shareholder's
     social security number or other identifying information.

o    The shareholder  will then be given an opportunity to authorize  proxies to
     vote his or her shares at the meeting in accordance with the  shareholder's
     instructions.

o    To ensure that the shareholder's instructions have been recorded correctly,
     the shareholder will also receive a confirmation of the voting instructions
     by mail.

o    A toll-free number will be available in case the voting information
     contained in the confirmation is incorrect.

o    If the shareholder decides after voting by telephone to attend the meeting,
     the  shareholder  can  revoke the proxy at that time and vote the shares at
     the meeting.


                        OWNERSHIP OF SHARES IN THE FUNDS

To the knowledge of the fund, as of September 14, 1999, the following persons
owned of record or beneficially 5% or more of the outstanding shares of your
fund.

- --------------------------------------------------------------------------------
Name and Address                                      Number of Shares Owned
- --------------------------------------------------------------------------------

As of September 14, 1999, the trustees and officers of the fund owned in the
aggregate less than 1% of the outstanding shares of the fund.


                                       17
<PAGE>


                                   Exhibit A

                    JOHN HANCOCK INSTITUTIONAL SERIES TRUST

                     John Hancock International Equity Fund



                       Sub-Investment Management Contract









                                                     Dated December 1, 1999


<PAGE>



                           JOHN HANCOCK ADVISERS, INC.
                              101 Huntington Avenue
                           Boston, Massachusetts 02199


                    JOHN HANCOCK INSTITUTIONAL SERIES TRUST
                    - John Hancock International Equity Fund
                              101 Huntington Avenue
                           Boston, Massachusetts 02199


                   INDOCAM INTERNATIONAL INVESTMENT SERVICES
                              90 Boulevard Pasteur
                               Paris, FRANCE 75015


                       Sub-Investment Management Contract
                       ----------------------------------


Ladies and Gentlemen:

         John Hancock Institutional Series Trust (the "Trust") has been
organized as a business trust under the laws of The Commonwealth of
Massachusetts to engage in the business of an investment company. The Trust's
shares of beneficial interest may be classified into series, each series
representing the entire undivided interest in a separate portfolio of assets.
Series may be established or terminated from time to time by action of the Board
of Trustees of the Trust. As of the date hereof, the Trust has eleven series of
shares, representing interests in John Hancock Active Bond Fund, John Hancock
Dividend Performers Fund, John Hancock Independence Balanced Fund, John Hancock
Independence Diversified Core Equity Fund II, John Hancock Core Growth Fund,
John Hancock Independence Medium Capitalization Fund, John Hancock Core Value
Fund, John Hancock International Equity Fund, John Hancock Medium Capitalization
Growth Fund, John Hancock Small Capitalization Growth Fund, and John Hancock
Small Capitalization Value Fund.

         The Board of Trustees of the Trust (the "Trustees") has selected John
Hancock Advisers, Inc. (the "Adviser") to provide overall investment advice and
management for the John Hancock International Equity Fund (the "Fund"), and to
provide certain other services, under the terms and conditions provided in the
Investment Management Contract, dated March 30, 1995, between the Trust, the
Fund and the Adviser (the "Investment Management Contract").

         The Adviser and the Trustees have selected Indocam International
Investment Services (the "Sub-Adviser") to provide the Adviser and the Fund with
the advice and services set forth below, and the Sub-Adviser is willing to
provide such advice and services, subject to the review of the Trustees and
overall supervision of the Adviser, under the terms and conditions hereinafter
set forth. The Sub-Adviser hereby represents and warrants that it is registered
as an investment adviser under the Investment Advisers Act of 1940, as amended.
Accordingly, the Trust, on behalf of the Fund, and the Adviser agree with the
Sub-Adviser as follows:

<PAGE>


1.       Delivery of Documents.  The Trust has furnished the Sub-Adviser with
copies, properly certified or otherwise authenticated, of each of the
following:

         (a)  Declaration  of Trust of the Trust,  dated  October 31,  1994,  as
amended from time to time (the "Declaration of Trust");

         (b)  By-Laws of the Trust as in effect on the date hereof;

         (c)  Resolutions of the Trustees approving the form of this Agreement
by and among the Adviser, the Sub-Adviser and the Trust, on behalf of the Fund;

         (d)  Resolutions of the Trustees selecting the Adviser as
investment adviser for the Fund and approving the form of the Investment
Management Contract;

         (e)  the Investment Management Contract;

         (f)  the Fund's portfolio compliance checklists;

         (g)  the Fund's current Registration Statement, including the
Fund's Prospectus and Statement of Additional Information; and

         (h)  the Fund's Code of Ethics.

         The Trust will furnish to the Sub-Adviser from time to time copies,
properly certified or otherwise authenticated, of all amendments of or
supplements to the foregoing, if any.

2.           Investment Services. The Sub-Adviser will use its best efforts to
provide to the Fund continuing and suitable investment advice with respect to
investments, consistent with the investment policies, objectives and
restrictions of the Fund as set forth in the Fund's Prospectus and Statement of
Additional Information. In the performance of the Sub-Adviser's duties
hereunder, subject always (x) to the provisions contained in the documents
delivered to the Sub-Adviser pursuant to Section 1, as each of the same may from
time to time be amended or supplemented, and (y) to the limitations set forth in
the Registration Statement of the Trust, on behalf of the Fund, as in effect
from time to time under the Securities Act of 1933, as amended, and the
Investment Company Act of 1940, as amended (the "1940 Act"), the Sub-Adviser
will have investment discretion with respect to the Fund and will at its own
expense:

         (a) furnish  the Adviser and the Fund with advice and  recommendations,
consistent with the investment policies, objectives and restrictions of the Fund
as set forth in the Fund's  Prospectus and Statement of Additional  Information,
with respect to the purchase,  holding and  disposition of portfolio  securities
including the purchase and sale of options;

                                       2
<PAGE>


         (b)  furnish  the  Adviser and the Fund with advice as to the manner in
which voting rights,  subscription rights, rights to consent to corporate action
and any other rights  pertaining to the Fund's  assets shall be  exercised,  the
Fund having the responsibility to exercise such voting and other rights;

         (c)  furnish  the  Adviser  and the Fund with  research,  economic  and
statistical  data in  connection  with the  Fund's  investments  and  investment
policies;

         (d)  submit  such  reports  relating  to the  valuation  of the  Fund's
securities as the Trustees may reasonably request;

         (e)  subject  to  prior  consultation  with  the  Adviser,   engage  in
negotiations relating to the Fund's investments with issuers, investment banking
firms, securities brokers or dealers and other institutions or investors;

         (f) consistent with  provisions of Section 7 of this  Agreement,  place
orders for the purchase,  sale or exchange of portfolio  securities with brokers
or  dealers  selected  by the  Adviser  or the  Sub-Adviser,  provided  that  in
connection  with the placing of such orders and the selection of such brokers or
dealers the  Sub-Adviser  shall seek to obtain  execution and pricing within the
policy guidelines determined by the Trustees and set forth in the Prospectus and
Statement of  Additional  Information  of the Fund as in effect and furnished to
the Sub-Adviser from time to time;

         (g) from time to time or at any time  requested  by the  Adviser or the
Trustees,  make  reports  to the  Adviser  or  the  Trust  of the  Sub-Adviser's
performance of the foregoing services;

         (h) subject to the  supervision of the Adviser,  maintain all books and
records with respect to the Fund's securities  transactions required by the 1940
Act, and preserve such records for the periods  prescribed  therefor by the 1940
Act (the Sub-Adviser  agrees that such records are the property of the Trust and
copies will be surrendered to the Trust promptly upon request therefor);

         (i) give  instructions  to the Fund's  custodian  as to  deliveries  of
securities  to and from such  custodian  and transfer of payment of cash for the
account of the Fund,  and advise the  Adviser on the same day such  instructions
are given; and

         (j)  cooperate  generally  with  the Fund and the  Adviser  to  provide
information  necessary  for  the  preparation  of  registration  statements  and
periodic  reports  to be filed  with the  Securities  and  Exchange  Commission,
including Form N-1A, periodic statements,  shareholder  communications and proxy
materials  furnished to holders of shares of the Fund,  filings with state "blue
sky"  authorities and with United States  agencies  responsible for tax matters,
and other reports and filings of like nature.

3.    Expenses Paid by the  Sub-Adviser.  The  Sub-Adviser will pay the cost of
maintaining the staff and personnel  necessary for it to perform its obligations
under this Agreement, the expenses of office rent, telephone, telecommunications
and other facilities it is obligated to provide in order to perform the services
specified in Section 2, and any other expenses incurred by it in connection with
the performance of its duties hereunder.

                                       3
<PAGE>


4.            Expenses of the Fund Not Paid by the Sub-Adviser. The Sub-Adviser
will not be required to pay any expenses which this Agreement does not expressly
make payable by the Sub-Adviser. In particular, and without limiting the
generality of the foregoing but subject to the provisions of Section 3, the
Sub-Adviser will not be required to pay under this Agreement:

         (a) the  compensation  and  expenses  of  Trustees  and of  independent
advisers,  independent  contractors,  consultants,  managers  and  other  agents
employed by the Trust or the Fund other than through the Sub-Adviser;

         (b) legal, accounting and auditing fees and expenses of the
Trust or the Fund;

         (c) the fees and  disbursements  of custodians and  depositories of the
Trust or the Fund's assets, transfer agents,  disbursing agents, plan agents and
registrars;

         (d) taxes  and  governmental  fees  assessed  against  the Trust or the
Fund's assets and payable by the Trust or the Fund;

         (e) the  cost  of  preparing  and  mailing  dividends,  distributions,
reports,  notices and proxy  materials to  shareholders of the Trust or the Fund
except that the  Sub-Adviser  shall bear the costs of providing the  information
referred to in Section 2(j) to the Adviser;

         (f) brokers' commissions and underwriting fees; and

         (g) the expense of periodic calculations of the net asset value of the
shares of the Fund.

5.          Compensation of the Sub-Adviser. For all services to be rendered,
facilities furnished and expenses paid or assumed by the Sub-Adviser as herein
provided for the Fund, the Adviser will pay the Sub-Adviser quarterly, in
arrears, a fee at the annual rate of 55% of the investment advisory fee received
by the Adviser.

         The "average daily net assets" of the Fund shall be determined on the
basis set forth in the Fund's Prospectus or otherwise consistent with the 1940
Act and the regulations promulgated thereunder. The Sub-Adviser will receive a
pro rata portion of such fee for any periods in which the Sub-Adviser advises
the Fund less than a full quarter. The Fund shall not be liable to the
Sub-Adviser for the Sub-Adviser's compensation hereunder. Calculations of the
Sub-Adviser's fee will be based on average net asset values as provided by the
Adviser.

         In addition to the foregoing, the Sub-Adviser may from time to time
agree not to impose all or a portion of its fee otherwise payable hereunder (in
advance of the time such fee or portion thereof would otherwise accrue) and/or
undertake to pay or reimburse the Fund for all or a portion of its expenses not
otherwise required to be borne or reimbursed by it. Any such fee reduction or
undertaking may be discontinued or modified by the Sub-Adviser at any time.

                                       4
<PAGE>


6.       Other Activities of the Sub-Adviser and Its Affiliates. Nothing
herein contained shall prevent the Sub-Adviser or any associate of the
Sub-Adviser from engaging in any other business or from acting as investment
adviser or investment manager for any other person or entity, understood that
officers, directors and employees of the Sub-Adviser or its affiliates may
continue to engage in providing portfolio management services and advice to
other investment companies, whether or not registered, to other investment
advisory clients of the Sub-Adviser or its affiliates and to said affiliates
themselves.

7.       Avoidance of Inconsistent Position. In connection with purchases or
sales of portfolio securities for the account of the Fund, neither the
Sub-Adviser nor any of its investment management subsidiaries nor any of such
investment management subsidiaries' directors, officers or employees will act as
principal or agent or receive any commission, except as may be permitted by the
1940 Act and rules and regulations promulgated thereunder. The Sub-Adviser shall
not knowingly recommend that the Fund purchase, sell or retain securities of any
issuer in which the Sub-Adviser has a financial interest without obtaining prior
approval of the Adviser prior to the execution of any such transaction.

         Nothing herein contained shall limit or restrict the Sub-Adviser or any
of its officers,  affiliates or employees from buying, selling or trading in any
securities  for its or  their  own  account  or  accounts.  The  Trust  and Fund
acknowledge the Sub-Adviser and its officers, affiliates, and employees, and its
other clients may at any time have,  acquire,  increase,  decrease or dispose of
positions in  investments  which are at the same time being acquired or disposed
of hereunder.  The Sub-Adviser  shall have no obligation to acquire with respect
to the Fund, a position in any investment which the  Sub-Adviser,  its officers,
affiliates  or  employees  may acquire for its or their own  accounts or for the
account of another client,  if in the sole discretion of the Sub-Adviser,  it is
not feasible or desirable to acquire a position in such  investment on behalf of
the Fund. Nothing herein contained shall prevent the Sub-Adviser from purchasing
or recommending  the purchase of a particular  security for one or more funds or
clients while other funds or clients may be selling the same security.

8.           No Partnership or Joint Venture. The Trust, the Fund, the Adviser
and the Sub-Adviser are not partners of or joint venturers with each other and
nothing herein shall be construed so as to make them such partners or joint
venturers or impose any liability as such on any of them.

9.         Name of the Trust and the Fund. The Trust and the Fund may use the
name "John Hancock" or any name or names derived from or similar to the names
"John Hancock Advisers, Inc." or "John Hancock Mutual Life Insurance Company"
only for so long as this Agreement remains in effect. At such time as this
Agreement shall no longer be in effect, the Trust and the Fund will (to the
extent that they lawfully can) cease to use such a name or any other name
indicating that the Fund is advised by or otherwise connected with the Adviser.
The Fund acknowledges that it has adopted the name John Hancock International
Equity Fund through permission of John Hancock Mutual Life Insurance Company, a
Massachusetts insurance company, and agrees that John Hancock Mutual Life
Insurance Company reserves to itself and any successor to its business the right
to grant the nonexclusive right to use the name "John Hancock" or any similar
name or names to any other corporation or entity, including but not limited to
any investment company of which John Hancock Mutual Life Insurance Company or
any subsidiary or affiliate thereof shall be the investment adviser.

                                       5
<PAGE>


10.          Limitation of Liability of Sub-Adviser. The Sub-Adviser shall not
be liable for any error of judgment or mistake of law or for any loss suffered
by the Trust or the Fund or the Adviser in connection with the matters to which
this Agreement relates, except a loss resulting from willful misfeasance, bad
faith or gross negligence on the Sub-Adviser's part in the performance of its
duties or from reckless disregard by it of its obligations and duties under this
Agreement. Any person, even though also employed by the Sub-Adviser, who may be
or become an employee of and paid by the Trust or the Fund shall be deemed, when
acting within the scope of his employment by the Trust or the Fund, to be acting
in such employment solely for the Trust or the Fund and not as the Sub-Adviser's
employee or agent.

11.          Duration and Termination of this Agreement. This Agreement shall
remain in force until June 30, 2001, and from year to year thereafter, but only
so long as such continuance is specifically approved at least annually by (a) a
majority of the Trustees who are not interested persons of the Adviser, the
Sub-Adviser, or (other than as Board members) of the Trust or the Fund, cast in
person at a meeting called for the purpose of voting on such approval, and (b)
either (i) the Trustees or (ii) a majority of the outstanding voting securities
of the Fund. This Agreement may, on 60 days' written notice, be terminated at
any time without the payment of any penalty by the Trust or the Fund by vote of
a majority of the outstanding voting securities of the Fund, by the Trustees,
the Adviser or the Sub-Adviser. Termination of this Agreement with respect to
the Fund shall not be deemed to terminate or otherwise invalidate any provisions
of any contract between the Sub-Adviser and any other series of the Trust. This
Agreement shall automatically terminate in the event of its assignment or upon
termination of the Investment Management Contract. In interpreting the
provisions of this Section 11, the definitions contained in Section 2(a) of the
1940 Act (particularly the definitions of "assignment," "interested person" or
"voting security"), shall be applied.

12.         Amendment of this Agreement. No provision of this Agreement may be
changed, waived, discharged or terminated orally, but only by an instrument in
writing signed by the party against which enforcement of the change, waiver,
discharge or termination is sought, and no amendment, transfer, assignment,
sale, hypothecation or pledge of this Agreement shall be effective until
approved by (a) the Trustees, including a majority of the Trustees who are not
interested persons of the Adviser, the Sub-Adviser, or (other than as Board
members) of the Trust or the Fund, cast in person at a meeting called for the
purpose of voting on such approval, and (b) a majority of the outstanding voting
securities of the Fund, as defined in the 1940 Act.

13.         Governing Law. This Agreement shall be governed and construed in
accordance with the laws of the Commonwealth of Massachusetts.

                                       6
<PAGE>


14.         Severability. The provisions of this Agreement are independent of
and separable from each other, and no provision shall be affected or rendered
invalid or unenforceable by virtue of the fact that for any reason any other or
others of them may be deemed invalid or unenforceable in whole or in part.

15.         Miscellaneous. (a) The captions in this Agreement are included for
convenience of reference only and in no way define or limit any of the
provisions hereof or otherwise affect their construction or effect. This
Agreement may be executed simultaneously in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument. The name John Hancock Institutional Series Trust is
the designation of the Trustees under the Declaration of Trust dated October 31,
1994, as amended from time to time. The Declaration of Trust has been filed with
the Secretary of The Commonwealth of Massachusetts. The obligations of the Trust
and the Fund are not personally binding upon, nor shall resort be had to the
private property of, any of the Trustees, shareholders, officers, employees or
agents of the Fund, but only the Fund's property shall be bound. The Trust or
the Fund shall not be liable for the obligations of any other series of the
Trust. (b) Any information supplied by the Sub-Adviser, which is not otherwise
in the public domain, in connection with the performance of its duties hereunder
is to be regarded as confidential and for use only by the Fund and/or its
agents, and only in connection with the Fund and its investments.

                             Yours very truly,

                             JOHN HANCOCK INSTITUTIONAL SERIES TRUST
                             on behalf of John Hancock International Equity Fund

                             By:
                                --------------------------------------
                                             President

The foregoing contract is hereby agreed to as of the date hereof.

JOHN HANCOCK ADVISERS, INC.

By: __________________________________________
    Vice Chairman and Chief Investment Officer

INDOCAM INTERNATIONAL INVESTMENT SERVICES

By: ____________________________
Name:
Title:

<PAGE>


                           VOTE THIS PROXY CARD TODAY!
                    YOUR PROMPT RESPONSE WILL SAVE YOUR FUND
                       THE EXPENSE OF ADDITIONAL MAILINGS

                     JOHN HANCOCK INTERNATIONAL EQUITY FUND
                SPECIAL MEETING OF SHAREHOLDERS- DECEMBER 1, 1999

The undersigned, revoking previous proxies, hereby appoint(s) Edward J.
Boudreau, Jr., Anne C. Hodsdon, Susan S. Newton and James J. Stokowski, with
full power of substitution in each, to vote all the shares of beneficial
interest of John Hancock International Equity Fund ("International Equity")
which the undersigned is (are) entitled to vote at the Special Meeting of
Shareholders (the "Meeting") of International Equity to be held at 101
Huntington Avenue, Boston, Massachusetts 02199, on December 1, 1999 at 9:00
a.m., eastern time, and any adjournment(s) of the Meeting. All powers may be
exercised by a majority of all proxy holders or substitutes voting or acting,
or, if only one votes and acts, then by that one. Receipt of the Proxy Statement
dated October 5, 1999 is hereby acknowledged. If not revoked, this proxy shall
be voted for the proposals.


Date___________________________________,


o    Please complete, sign, date and return this proxy in the enclosed
     envelope as soon as possible.

o    Please sign  exactly as your name or names  appear  left.  When signing as
     attorney,  executor,  administrator,  trustee or guardian, please give your
     full title as such.

o    If a Corporation, please sign in full corporate name by president or
     other authorized officer.

o    If a partnership, please sign in partnership name by authorized person


- ----------------------------------------
Signature




<PAGE>




                           VOTE THIS PROXY CARD TODAY!
                    YOUR PROMPT RESPONSE WILL SAVE YOUR FUND
                       THE EXPENSE OF ADDITIONAL MAILINGS

Specify your desired action by a check mark in the appropriate space. This proxy
will be voted as specified. If no specification is made, the proxy will be voted
in favor of each item. The persons named as proxies have discretionary authority
which they intend to exercise in favor of the proposals referred to and
according to their best judgment as to any other matters which properly come
before the meeting.

1      To approve a new sub-investment management contract between John
       Hancock Advisers, Inc. and Indocam International Investment Services.

         FOR        AGAINST        ABSTAIN

        [   ]        [   ]          [   ]

2 (a)  To amend the fund's investment restriction on borrowing money.

         FOR        AGAINST        ABSTAIN

        [   ]        [   ]          [   ]

2 (b)  To amend the fund's investment restriction on making loans.

         FOR        AGAINST        ABSTAIN

        [   ]        [   ]          [   ]


           PLEASE DO NOT FORGET TO SIGN THE REVERSE SIDE OF THIS CARD





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