AVIGEN INC \DE
SC 13G/A, 1999-02-16
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                    -----------------------------------------


                                  SCHEDULE 13G
                               (Amendment No. 2)

                    Under the Securities Exchange Act of 1934
                    -----------------------------------------


                                  Avigen, Inc.
                    -----------------------------------------
                                (Name of Issuer)


                    Common Stock, par value $0.001 per share
                   ------------------------------------------
                         (Title of Class of Securities)

                                    053690103
                                  -------------
                                 (CUSIP Number)


        Check the  appropriate  box to designate the rule pursuant to which this
Schedule is filed:

                                    [ ]   Rule 13d-1(b)
                                    [X]   Rule 13d-1(c)
                                    [ ]   Rule 13d-1(d)

        *The  remainder  of this cover page shall be filled out for a  reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

        The  information  required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  see
the Notes to Schedule 13G).



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<PAGE>

                                  SCHEDULE 13G

CUSIP No. 053690103                                                  Page 2 of 5
- --------------------------------------------------------------------------------
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF MEMBER OF A GROUP        (a) |_|    (b) |_|
- --------------------------------------------------------------------------------
3)      SEC USE ONLY
- --------------------------------------------------------------------------------
4)      CITIZENSHIP OR PLACE OF ORGANIZATION
        United States
- --------------------------------------------------------------------------------
                      5)     SOLE VOTING POWER
                             337,730 /1/
        NUMBER        ----------------------------------------------------------
        OF            6)     SHARED VOTING POWER
        SHARES               15,798 /2/
        BENEFICIALLY  ----------------------------------------------------------
        OWNED BY      7)     SOLE DISPOSITIVE POWER
        EACH                 337,730 /1/
        REPORTING     ----------------------------------------------------------
        PERSON        8)     SHARED DISPOSITIVE POWER
        WITH                 15,798
- --------------------------------------------------------------------------------
9)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        353,528 /3/
- --------------------------------------------------------------------------------
10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
                                                                             [ ]
- --------------------------------------------------------------------------------
11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
        4.77%
- --------------------------------------------------------------------------------
12)     TYPE OF REPORTING PERSON
        IN
- --------------------------------------------------------------------------------

- ---------------
        /1/ Includes   44,803  shares  of  common  stock  held  by  June  Street
Corporation  and  44,803  shares  of  common  stock  held by  Huntington  Street
Corporation. Dr. Rosenwald is the president and sole shareholder of each of June
Street Corporation and Huntington Street Corporation.


        /2/ Includes  5,129 shares of common stock of the Issuer  issuable  upon
conversion  of 5,129  shares of Series C Preferred  Stock,  513 shares of common
stock of the Issuer issuable upon conversion of 513 shares of Series C Preferred
Stock receivable upon exercise of warrants and warrants to purchase 2,708 shares
of  common  stock  of  the  Issuer  held  by  Aries  Domestic  Fund,  L.P.  (the
"Partnership")  and 5,129  shares of common  stock of the Issuer  issuable  upon
conversion  of 5,129  shares of Series C Preferred  Stock,  513 shares of common
stock of the Issuer issuable upon conversion of 513 shares of Series C Preferred
Stock receivable upon exercise of warrants and warrants to purchase 1,806 shares
of common stock of the Issuer held by The Aries  Master  Fund,  a Cayman  Island
exempted company (the "Master Fund").  Paramount Capital Asset Management,  Inc.
("PCAM") is the general partner of the Partnership and the investment manager of
the Master Fund. Dr. Rosenwald is the chairman and sole shareholder of PCAM.

        /3/ Does  not  include  160,559  shares  of  common  stock  held  by Dr.
Rosenwald's  wife and 66,912  shares of common  stock of the Issuer  held by Dr.
Rosenwald's  wife in trust for the benefit of his minor children,  for which Dr.
Rosenwald disclaims beneficial ownership.



                                        2

<PAGE>

Item 1.

        (a)           Name of Issuer:

                      Avigen, Inc. (the "Company")

        (b)           Address of Issuer's Principal Executive Offices:

                      1201 Harbor Way Parkway, #1000
                      Alameda, CA 94502

Item 2.

        (a)           Name of Person Filing:

                      Lindsay A. Rosenwald, M.D.

        (b)           Address of Principal Business Office or, if None, 
                      Residence:

                      Paramount Capital
                      787 Seventh Avenue, 48th Floor
                      New York, New York 10019

        (c)           Citizenship:

                      Dr. Rosenwald is a citizen of the United States.

        (d)           Title of Class of Securities:

                      Common Stock, $0.001 par value ("shares").

        (e)           CUSIP#:

                      053690103

Item 3.               Check the box if this statement is filed pursuant to Rule 
                      13d-1(c)                                              [  ]

Item 4.               Ownership:

                      For  information  concerning the ownership of Common Stock
                      of the  Company  by the  Reporting  Persons,  see  Items 5
                      through 9 and 11 of the



                                        3

<PAGE>

                      cover pages to this schedule 13G and footnotes thereto.

Item 5.               Ownership of Five Percent or Less of a Class:

                      As of  the  date  of  the  filing  of  this  Schedule  13G
                      Amendment, Dr. Rosenwald ceased to be the beneficial owner
                      of more than 5% of the shares of the Issuer.

Item 6.               Ownership  of More than Five  Percent on Behalf of Another
                      Person:

                      Not applicable.

Item 7.               Identification  and Classification of the Subsidiary Which
                      Acquired  the  Security  Being  Reported  On By the Parent
                      Holding Company:

                      Not applicable.

Item 8.               Identification and Classification of Members of the Group:

                      Not applicable.

Item 9.               Notice of Dissolution of Group:

                      Not applicable.

Item 10.              Certification:

                      By  signing  below  I  certify  that,  to the  best  of my
        knowledge and belief, the securities referred to above were not acquired
        and are not held for the  purpose of or with the effect of  changing  or
        influencing  the  control of the issuer of the  securities  and were not
        acquired and are not held in connection  with or as a participant in any
        transaction having that purpose or effect.



                                       4
<PAGE>

                                    SIGNATURE

        After  reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.



Dated:   February 16, 1999
         New York, NY                 By  /s/ Lindsay A. Rosenwald, M.D.  
                                               ---------------------------------
                                                   Lindsay A. Rosenwald, M.D.



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