AVIGEN INC \DE
424B3, 2000-01-13
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1
                                                Filed Pursuant to Rule 424(b)(3)
                                                           File Number 333-92355




                              PROSPECTUS SUPPLEMENT
                     (To Prospectus Dated December 15, 1999)

                                  AVIGEN, INC.


                                2,962,047 SHARES

                                  COMMON STOCK

     As set forth in the Prospectus, dated December 15, 1999, with respect to
the offer and sale of 2,962,047 shares of common stock of Avigen, Inc., from
time to time one or more of the selling stockholders listed under the caption
"Selling Stockholders" in the Prospectus may transfer, pledge, donate or assign
such selling stockholders' shares of common stock to lenders or others and each
of such persons will be deemed to be a "selling stockholder" for purposes of the
Prospectus.

     Robert J. Conrads, one of the selling stockholders, exercised in full his
warrant to purchase 5,000 shares of Avigen common stock and transferred by gift
850 of such shares to Harvard University. As a result, 850 shares of the 5,000
shares of common stock disclosed as beneficially owned and being offered by Mr.
Conrads are owned and are being offered by Harvard Management Company on behalf
of Harvard University. As a result of the above, the disclosure regarding
beneficial ownership by Mr. Conrads and Harvard Management Company in the table
of selling stockholders under the caption "Selling Stockholders" in the
Prospectus is amended as below, and all other aspects of the table remain the
same.

                   SHARES BENEFICIALLY OWNED PRIOR TO OFFERING
<TABLE>
<CAPTION>
                                                 TOTAL NUMBER OF       NUMBER OF SHARES
                                                 SHARES OF COMMON        ISSUABLE UPON       PERCENT OF        TOTAL NUMBER OF
                                                STOCK BENEFICIALLY        EXERCISE OF       COMMON STOCK        SHARES BEING
             SELLING STOCKHOLDER                       HELD                 WARRANTS         OUTSTANDING           OFFERED
<S>                                                 <C>                      <C>                <C>               <C>
Robert J. Conrads...........................          4,150                     -                 *                  4,150


Harvard Management Company (4)..............        536,560                  89,285             4.21               536,560

</TABLE>

(4)  Of these shares, 850 are owned in the name of Harvard University, which may
     also be deemed to be a selling stockholder.

           THE DATE OF THIS PROSPECTUS SUPPLEMENT IS JANUARY 13, 2000.


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