MERRILL LYNCH GLOBAL INSTITUTIONAL SERIES INC
RW, 1996-08-13
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                                   April 19, 1996



BY FEDERAL EXPRESS
- ------------------

Mr. David L. Wills
Branch Chief
Division of Investment Management
Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, DC  20549

          Re:  Merrill Lynch Global Institutional Series, Inc.
               (File No. 33-56591)                            
               -----------------------------------------------

Dear Mr. Wills:

     As secretary of Merrill Lynch Global Institutional Series, Inc. (the
"Fund"), I hereby request that the Fund's Registration Statement under the
Securities Act of 1933, as amended, on Form N-1A be withdrawn.  The
Registration Statement was originally filed on November 23, 1994 and has
never been declared effective.  No shares of the Fund have been or will be
publicly sold.

     The Fund intends to deregister under the Investment Company Act of 1940,
as amended, by filing for an order declaring that the Fund has ceased to be
an investment company on Form N-8F as soon as practicable.

     Kindly acknowledge receipt of this filing by date-stamping the enclosed
copy of this letter and returning it in the enclosed, postage pre-paid
envelope.  Any questions or comments regarding this filing should be directed
to Susan Mattisinko at (212) 839-5428 or Ellen W. Harris at (212) 839-5583,
both at the law firm of Brown & Wood.

                                   Very truly yours,

                                   /s/ James W. Harshaw



                                   James W. Harshaw
                                   Secretary


Enclosure

cc:  Susan Mattisinko
     Brown & Wood



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