BAYER AG /FI
SC 13D, 1998-11-18
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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934


                        Millennium Pharmaceuticals, Inc.
                                (Name of Issuer)

                                  Common Stock
                         (Title of Class of Securities)

                                   0005999021
                                 (CUSIP Number)

                                 George J. Lykos
                                 Bayer Corporation
                                 400 Morgan Lane
                                 West Haven, CT 06516
                                 203-812-2401

                  (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)

                                November 10, 1998
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box o.

Check the following box if a fee is being paid with the statement |X|. (A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7).

Note:  Six copies of this statement, including all exhibits, should be filed
with the Commission.  See Rule 13d-1(a) for other parties to whom copies are to 
be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                                   Page 1 of 9

<PAGE>

                                  SCHEDULE 13D



CUSIP No.  0005999021                                       Page 2 of 9 Pages
           ----------                                            -------      
- --------------------------------------------------------------------------------


1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     Bayer AG


2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a)[ ]
                                                                         (b)[ ]

3          SEC USE ONLY


4          SOURCE OF FUNDS

           WC.

5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
           ITEMS 2(d) OR 2(e)          

          CITIZENSHIP OR PLACE OF ORGANIZATION

           Federal Republic of Germany


                            7          SOLE VOTING POWER

                                        4,957,660

         NUMBER OF          8          SHARED VOTING POWER      
          SHARES                                                         
       BENEFICIALLY                     0                        
         OWNED BY                                                        
           EACH             9          SOLE DISPOSITIVE POWER   
         REPORTING                                                       
          PERSON                        4,957,660                
           WITH                                                          
                           10          SHARED DISPOSITIVE POWER 
                                                                         
                                        0                        
                                         
                     
11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           4,957,660

12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES SHARES   [ ]

13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           14.4%

14         TYPE OF REPORTING PERSON

           CO
- --------------------------------------------------------------------------------
<PAGE>

Item 1.  Security and Issuer.

                  This  Statement  relates to shares of common stock,  $.001 par
value per share (the "Common  Stock"),  of Millennium  Pharmaceuticals,  Inc., a
Delaware  corporation (the "Issuer"),  which has its principal executive offices
at 238 Main Street, Cambridge, Massachusetts 02139-4815.

Item 2.  Identity and Background.

                  This Statement is being filed by Bayer AG ("Bayer"),  a German
corporation with its principal offices located in Leverkeusen, Germany. Bayer is
a German  multinational  pharmaceutical and chemical company.  Information as to
the executive officers and directors of Bayer is set forth in Exhibit A hereto.

                  During the past five  years,  neither  Bayer  nor,  to Bayer's
knowledge,  any of the  persons  listed  in  Exhibit A has been  convicted  in a
criminal  proceeding  (excluding traffic  violations and similar  misdemeanors).
During the past five years, neither Bayer nor, to Bayer's knowledge,  any of the
persons listed in Exhibit A has been a party to a civil proceeding of a judicial
or  administrative  body  of  competent  jurisdiction  and as a  result  of such
proceeding  was or is subject to a  judgment,  decree or final  order  enjoining
future violations of, or prohibiting or mandating activities subject to, federal
or state securities laws or finding any violation with respect to such laws.

Item 3.  Source and Amount of Funds or Other Consideration.

                  The  source of funds  used to  purchase  the  shares of Common
Stock was the  working  capital of Bayer.  Bayer paid  Ninety Six  Million,  Six
Hundred Thousand Dollars  ($96,600,000.00) to acquire 4,957,660 shares of Common
Stock (the "Shares").


Item 4.  Purpose of Transaction.

                  On November 10, 1998 Bayer acquired the Shares  pursuant to an
Investment  Agreement dated September 22, 1998 between Bayer and the Issuer (the
"Investment  Agreement").  Also on  September  22,  1998,  Bayer and the  Issuer
entered  into an agreement  (the  "Colloboration  Agreement")  pursuant to which
Bayer will receive access to key  technologies  in modern genome  research and a
flow of genome-based targets for drug development over a five-year period (which
period could be  shortened or  lengthened  in  accordance  with the terms of the
Collaboration  Agreement) (the "Program  Term").  The Issuer has filed a copy of
the  Collaboration  Agreement  with the SEC as an  exhibit to its report on Form
10-Q for the quarter ended September 30, 1998.

                    Bayer acquired the Shares for investment  purposes.  Bayer's
right to sell the  Shares and to acquire  additional  shares of Common  Stock is
limited  by  the  Investment  Agreement  (see  Item  6  below).  Subject  to the
Investment Agreement,  Bayer intends to review its investment in the Issuer on a
continuing  basis and,  depending  on various  factors,  including  the Issuer's
business affairs and financial  position,  other  developments  concerning the
Issuer,  the price  level of the  Common  Stock,  conditions  in the  securities
markets  and  general  economic  and  industry  conditions,  as  well  as  other
investment opportunities available to Bayer, may in the future take such actions
with respect to its investment in the Issuer as it deems appropriate in light of
the  circumstances  existing  from time to time.  Such  actions  may include the
purchase of additional  shares of Common Stock in the open market,  in privately
negotiated  transactions  or  otherwise,  or the  sale  at any  time of all or a
portion of the Shares or other  shares of Common  Stock  hereafter  acquired  by
Bayer to one or more purchasers.

                  Pursuant  to  the  Investment  Agreement  and  subject  to the
limitations  described  therein,  Bayer has the right during the Program Term to
have a representative attend each year two regular meetings of the board of

                                   Page 3 of 9

<PAGE>

directors of  Millennium,  to receive  copies of agendas and the minutes for all
board  meetings,  and once each quarter to receive a confidential  briefing from
officers  of  Millennium  regarding   Millennium's  business  and  strategy.  In
addition,  Bayer may engage in  communications  with one or more shareholders of
the Issuer, one or more officers of the Issuer and/or one or more members of the
board of  directors  of the  Issuer  and/or one or more  representatives  of the
Issuer regarding the Issuer, including but not limited to its operations.  Bayer
may discuss ideas that,  if effected,  may result in any of the  following:  the
acquisition   by  persons  of  additional   Common  Stock  of  the  Issuer,   an
extraordinary  corporate transaction involving the Issuer, and/or changes in the
board of directors or management of the Issuer.

                  Except as  described  above,  Bayer does not have any  current
plans or proposals that relate to or would result in any of the events set forth
in paragraphs (a) through (j) of Item 4. Bayer may, at any time and from time to
time,  review or  reconsider  its  position  and/or  change its  purpose  and/or
formulate plans or proposals without respect thereto.

Item 5.  Interest in Securities of the Issuer.

                  (a),  (b),  (c)  Bayer is the  beneficial  owner of  4,957,660
shares of Common Stock  (approximately 14.4% of the outstanding shares of Common
Stock).  Bayer is the  beneficial  owner of all of the  Shares  and has the sole
power to vote and  dispose  of all the  Shares.  On  November  10,  1998,  Bayer
acquired  the  Shares  from  the  Issuer  for an  aggregate  purchase  price  of
$96,600,000,  or $19.485  per  share,  pursuant  to the terms of the  Investment
Agreement.

                  (d), (e)   Not applicable.


Item 6.  Contracts, Arrangements, Understandings or Relationships with Respect 
to the Issuer.

                  (i) On September  22, 1998,  the Issuer and Bayer entered into
the  Investment  Agreement,  (the  "Investment  Agreement")  attached  hereto as
Exhibit B. Pursuant to the Investment Agreement,  the Issuer agreed to issue and
sell to Bayer and Bayer agreed to purchase from the Issuer  4,957,660  shares of
the Issuer's Common Stock for an aggregate purchase price of $96,600,000.

                  Bayer  has  certain   subscription   rights  pursuant  to  the
Investment Agreement (as more fully described therein). So long as Bayer has not
sold more than 1,000,000 Shares (as adjusted to reflect any stock splits,  stock
dividends and similar  recapitalizations)  (other than sales to affiliates),  if
the Issuer proposes the issuance of certain new securities,  then, prior to each
such issuance of such new securities, the Issuer shall offer to Bayer a pro rata
share of such new securities.  These subscription rights will terminate upon the
earlier of (i) a sale of all or  substantially  all of the assets or business of
the Issuer, by merger,  sale of assets or otherwise,  or (ii) termination of the
Program Term.

                  Pursuant  to the  Investment  Agreement,  prior  to the  third
anniversary   of  Bayer's   purchase  of  the  Shares,   except  under   certain
circumstances as more fully described in the Investment Agreement, Bayer and its
affiliates (i) will not acquire any direct or indirect  beneficial  ownership or
interest  in any  additional  securities  of  the  Issuer,  and  (ii)  will  not
participate  in the  solicitation  of proxies to vote  securities of the Issuer.
Prior to the second anniversary of such purchase,  Bayer will not sell, transfer
or otherwise dispose of any Shares (except to any affiliate of Bayer). After the
second  anniversary  of the Closing and prior to the  expiration  of the Program
Term, Bayer will not sell, transfer or otherwise dispose of, in any one calendar
year, more than 2,500,000 Shares (as adjusted to reflect any stock splits, stock
dividends  and similar  recapitalizations)  (except to an  affiliate  of Bayer).
After the second  anniversary  of the Closing and prior to the expiration of the
Program  Term,  if Bayer  proposes to sell any Shares  other than  pursuant to a
registration  statement  under the Securities Act, the Issuer shall have a right
of first negotiation with respect to the acquisition of those Shares proposed to
be sold. The foregoing

                                   Page 4 of 9

<PAGE>

restrictions on transfer of the Shares expire under certain  circumstances  more
fully described in the Investment Agreement.

                  The  description of the  Investment  Agreement is qualified in
its  entirety by reference  to such  agreement,  a copy of which is set forth as
Exhibit B hereto.

                  (ii) On November 10, 1998,  the Issuer and Bayer  entered into
the  Registration  Rights  Agreement,   (the  "Registration  Rights  Agreement")
attached hereto as Exhibit C. Pursuant to the Registration  Rights Agreement the
Issuer has agreed to provide  Bayer certain  demand and  piggyback  registration
rights for the shares.

                  Bayer has the right,  subject to  certain  exceptions,  to two
demand  registrations on any registration form that the Issuer chooses and which
the Issuer is eligible to use. Bayer may not demand  registration  of securities
prior to the second anniversary of the closing date of the Investment Agreement.
The  Issuer  may  postpone  (or  withdraw)  a  demand  registration,  under  the
circumstances specified in the Registration Rights Agreement.

                  Also pursuant to the Registration Rights Agreement,  Bayer has
certain  piggyback  registration  rights.  If the Issuer at any time proposes to
register any of its securities  under the Securities Act (other than pursuant to
a demand  registration or a Special  Registration as defined in the Registration
Rights  Agreement),  whether  or not for sale for its own  account  (a  "Company
Registration"),  upon the  written  request  of  Bayer,  the  Issuer  shall  use
reasonable  best efforts to cause all Shares that the Issuer has been  requested
by Bayer to register to be so registered  under the Securities Act to the extent
necessary to permit their disposition in accordance with the intended methods of
distribution specified in the request Bayer.

                  The  description  of  the  Registration  Rights  Agreement  is
qualified in its entirety by reference to such agreement, a copy of which is set
forth as Exhibit C hereto.


Item 7.  Material to be Filed as Exhibits.



Exhibit A      Information concerning Bayer's executive officers and directors.

Exhibit B      Investment Agreement dated as of September 22, 1998 by and 
               between the Issuer and Bayer.

Exhibit C      Registration Rights Agreement dated November 10, 1998 by and
               between the Issuer and Bayer.


                                   Page 5 of 9

<PAGE>


Signature

     After reasonable inquiry and to the best of my knowledge and belief, I 
certify that the information set forth in this statement is true and correct.

Date:  November 17, 1998                    Bayer AG

                                            

                                             By: /s/ Dr. Michael Strucksberg
                                                     Dr. Michael Strucksberg
                                            Its:     Deputy General Counsel



                                   Page 6 of 9

<PAGE>


                  DIRECTORS AND EXECUTIVE OFFICERS OF BAYER AG


                  The following table sets forth the name and present  principal
occupation or employment of each member of the  Supervisory  Board and the Board
of  Management  of Bayer AG. The  business  address of each of them is Bayer AG,
Leverkusen,  Germany.  Except  as  otherwise  indicated,  all such  persons  are
citizens of Germany and each  occupation  listed refers to employment with Bayer
AG.

Exhibit A


                                Supervisory Board

Name:                             Principal Present Occupation

Hermann J. Strenger               Chairman of the Supervisory Board, Former
                                  Chairman of the Company's Board of Management

Rolf Nietzarad                    Chemical Laboratory Technician,
                                  Vice Chairman of the Supervisory Board,
                                  Leverkusen

Werner Bischoff                   Member of the Executive Committee of the
                                  German Mine, Chemical and Power Workers
                                  Union,

Adolf Busbach                     Electrician

Martin Kohlhaussen                Chairman of the Board of Managing Directors
                                  of Commerzbank AG

Hilman Kopper                     Chairman of the Supervisory Board of
                                  Deutsche Bank AG

Dr. -Ing. Manfred Lennings        Management Consultant

Dr. h.c. Andre Leysen             Chairman of the Board of Administration of
(Citizen of Belgium)              Gevaert N.V.


                                   Page 7 of 9

<PAGE>


Helmut Oswald Maucher             President and Chief Executive Officer of
                                  Nestle S.A.

Dieter Meinhardt                  Machine Fitter

Hans-Dieter Peppmeier             Engineering Draftsman

Dr. Heinrich von Pierer           Chairman of the Board of Management
                                  of Siemens AG

Bernd Reckschwardt                Chemical Worker

Waltraud Schlaefke                Chemical Laboratory Technician

Hubertus Schmoldt                 Chairman of the German Mine, Chemical and
                                  Power Workers Union

Dieter Schulte                    Chairman of the German Unions Federation (DGB)

Lodewijk C. van Wachem            Chairman of the Supervisory Board of Royal 
(Citizen of the Netherlands)      Dutch Petroleum Company

Prof. Dr. Ernst-Ludwig Winnacker  President of the German Research Association,

Dr. Hermann Wunderlich            Former Vice Chairman of the Company's Board
                                  of Management

                                   Page 8 of 9

<PAGE>


                               Board of Management


Name:                             Principal Present Occupation


Dr. Manfred Schneider             Chairman of the Board of Management

Dr. Pol Bamelis                   Member of the Board of Management,
(Citizen of Belgium)              Representative for Business Segment Agfa

Dr. Dieter Becher                 Member of the Board of Management

Hans-Jurgen Mohr                  Member of the Board of Management

Dr. Udo Oels                      Member of the Board of Management,
                                  Representative for Business Segment Chemicals

Manfred Pfleger                   Member of the Board of Management

Werner Spinner                    Member of the Board of Management,
                                  Representative for Business Segment Polymers

Werner Wenning                    Member of the Board of Management, Chief
                                  Financial Officer

Dr. Walter Wenninger              Member of the Board of Management,
                                  Representative for Business Segment Health
                                  Care, Agriculture


                                   Page 9 of 9

<PAGE>
Exhibit B


                              INVESTMENT AGREEMENT

                         dated as of September 22, 1998

                                 by and between

                                    BAYER AG
                a corporation of the Federal Republic of Germany

                                       and

                        MILLENNIUM PHARMACEUTICALS, INC.,
                             a Delaware corporation




                                        i

<PAGE>



                                TABLE OF CONTENTS

                                                                            Page

ARTICLE I

   PURCHASE AND SALE OF SHARES.................................................1
   Section 1.1     Purchase and Sale...........................................1
   Section 1.2     Closing Date................................................1
   Section 1.3     Transactions at the Closing.................................2

ARTICLE II

   REPRESENTATIONS AND WARRANTIES..............................................2
   Section 2.1     Representations and Warranties of the Company...............2
   Section 2.2     Representations and Warranties of Purchaser................11

ARTICLE III

   EQUITY PURCHASES FROM THE COMPANY..........................................12
   Section 3.1     Subscription Rights........................................12
   Section 3.2     Issuance and Delivery of New Securities and Voting Stock...13
   Section 3.3     Termination of Article III.................................13

ARTICLE IV

   LIMITATIONS ON PURCHASES OF ADDITIONAL EQUITY SECURITIES...................13
   Section 4.1     Purchases of Equity Securities.............................13

ARTICLE V

   TRANSFER OF COMMON STOCK...................................................16
   Section 5.1     Limitations on Transfer....................................16

ARTICLE VI

   COVENANTS AND ADDITIONAL AGREEMENTS........................................18
   Section 6.1     Ordinary Course............................................18
   Section 6.2     Access and Information.....................................18
   Section 6.3     Further Actions............................................18
   Section 6.4     Further Assurances.........................................19
   Section 6.5     Board Attendance Rights and Rights to Information about Board
                   and the Company............................................19

                                       ii

<PAGE>

ARTICLE VII

   CONDITIONS PRECEDENT.......................................................19
   Section 7.1     Each Party's Obligations...................................20
   Section 7.2     Conditions to the Obligations of the Company...............20
   Section 7.3     Conditions to the Obligations of Purchaser.................20

ARTICLE VIII

   TERMINATION................................................................21
   Section 8.1     Termination................................................21
   Section 8.2     Effect of Termination......................................23

ARTICLE IX

   INDEMNIFICATION............................................................23
   Section 9.1     Indemnification of Purchaser...............................23
   Section 9.2     Indemnification Procedures.................................23
   Section 9.3     Survival of  Representations and Warranties................24

ARTICLE X

   INTERPRETATION; DEFINITIONS................................................24
   Section 10.1    Interpretation.............................................24
   Section 10.2    Definitions................................................25

ARTICLE XI

   MISCELLANEOUS..............................................................29
   Section 11.1    Severability...............................................30
   Section 11.2    Specific Enforcement.......................................30
   Section 11.3    Entire Agreement...........................................30
   Section 11.4    Counterparts...............................................30
   Section 11.5    Notices....................................................30
   Section 11.6    Amendments.................................................32
   Section 11.7    Cooperation................................................32
   Section 11.8    Successors and Assigns.....................................32
   Section 11.9    Expenses and Remedies......................................32
   Section 11.10   Transfer of Shares.........................................32
   Section 11.11   Governing Law..............................................33
   Section 11.12   Publicity..................................................33
   Section 11.13   No Third Party Beneficiaries...............................33
   Section 11.14   Consent to Jurisdiction....................................33

                                       iii

<PAGE>


                              INVESTMENT AGREEMENT


         THIS INVESTMENT AGREEMENT (the "Agreement") is made as of September 22,
1998 by and between  MILLENNIUM  PHARMACEUTICALS,  INC., a Delaware  corporation
(the  "Company"),  and BAYER AG, a corporation  organized  under the laws of the
Federal Republic of Germany ("Purchaser").

         WHEREAS,  the  Company  and  Purchaser  are  parties  to  that  certain
Agreement,  dated as of the date hereof (the "Collaboration  Agreement"),  which
contains  the  terms  and  conditions  on  which  the  parties  have  agreed  to
collaborate on a small molecule drug discovery program; and

         WHEREAS,   in  connection  with  the  execution  of  the  Collaboration
Agreement, Purchaser wishes to purchase from the Company, and the Company wishes
to sell to Purchaser,  shares of the Company's Common Stock, $.001 par value per
share  ("Common  Stock"),  on the terms and subject to the  conditions set forth
herein;

         WHEREAS,  in connection with such sale and purchase of shares of Common
Stock,  the  Company  and  Purchaser  wish to enter into a  registration  rights
agreement  (the  "Registration  Rights  Agreement"),  substantially  in the form
attached hereto as Exhibit A.

         NOW,  THEREFORE,  in  consideration  of the  premises  and  the  mutual
covenants set forth herein, the Company and Purchaser agree as follows:


                                    ARTICLE I

                           PURCHASE AND SALE OF SHARES

         Section 1.1 Purchase and Sale.  Subject to the terms and  conditions of
this Agreement,  the Company agrees to issue and sell to Purchaser and Purchaser
agrees to purchase from the Company  4,957,660  shares of the  Company's  Common
Stock (the  "Shares"),  at a purchase price of $19.485 per share (which purchase
price  reflects the greater of (i) 115% of the average  daily closing price of a
share of the Company's Common Stock over the period from March 1, 1998 to August
31, 1998 or (ii) 100% of the closing  price of a share of the  Company's  Common
Stock on  September  21,  1998) for an  aggregate  purchase  price of Ninety Six
Million, Six Hundred Thousand Dollars ($96,600,000) (the "Purchase Price").

         Section 1.2 Closing Date.  The closing of the purchase and sale of the
Shares  hereunder (the "Closing") shall be held at the offices of Hale and Dorr,
60 State Street, Boston, Massachusetts, at 10:00 a.m., Boston time, on the third
Business Day following the first date on which all the conditions to Closing set
forth in Article VII have been  satisfied  or waived,  or at such other,  place,
time and date as the Company and Purchaser shall agree. The Company shall

                                        1

<PAGE>

give  Purchaser  three (3) Business Days prior notice of the date the Closing is
scheduled to occur.  The date of the Closing is  hereinafter  referred to as the
"Closing Date."

         Section 1.3 Transactions at the Closing. At the Closing, subject to the
terms and conditions of this Agreement,  (a) the Company shall issue and sell to
Purchaser and Purchaser shall purchase the Shares; (b) the Company shall deliver
to Purchaser a certificate  representing  the Shares,  registered in the name of
Purchaser  against payment of the Purchase Price by wire transfer of immediately
available funds to an account or accounts  previously  designated by the Company
no less than five (5)  Business  Days  prior to the  Closing  Date;  and (c) the
Company and Purchaser shall enter into the Registration Rights Agreement.


                                   ARTICLE II

                         REPRESENTATIONS AND WARRANTIES

         Section 2.1 Representations and Warranties of the Company.  The Company
hereby represents and warrants to Purchaser as follows:

                  (a) Corporate Organization.  The Company is a corporation duly
         organized,  validly existing and in good standing under the laws of the
         State of  Delaware.  Each  Subsidiary  is duly  organized  and  validly
         existing and, if applicable, is in good standing, under the laws of the
         jurisdiction of its incorporation or organization.  Each of the Company
         and its  Subsidiaries is duly qualified or licensed and, if applicable,
         is in good standing as a foreign  corporation,  in each jurisdiction in
         which  the  properties  owned,  leased  or  operated,  or the  business
         conducted,  by it require such  qualification or licensing,  except for
         any  such  failure  so  to  qualify  or  be  in  good  standing  which,
         individually  or in the  aggregate,  would not have a Material  Adverse
         Effect on the Company and its  Subsidiaries,  taken as a whole. Each of
         the  Subsidiaries has the requisite power and authority to carry on its
         business as it is now being conducted.  The Company has heretofore made
         available to Purchaser  complete and correct copies of the  Certificate
         of Incorporation of the Company (the "Company Charter") and the By-laws
         of  the  Company  (the  "Company   By-Laws")  and  the  certificate  of
         incorporation and by-laws, or the comparable  organizational documents,
         of each of its  Subsidiaries,  each as amended to date and currently in
         full force and effect.

                  (b)  Corporate  Authority.   The  Company  has  the  requisite
         corporate  power and  authority  to execute,  deliver and perform  this
         Agreement and the  Registration  Rights Agreement and to consummate the
         transactions  contemplated hereby and thereby. The execution,  delivery
         and performance of this Agreement and the Registration Rights Agreement
         by the Company,  the issuance and sale by the Company of the Shares and
         the performance by the Company of the other  transactions  contemplated
         hereby and thereby have been duly  authorized by the Company's Board of
         Directors, and no other corporate

                                        2

<PAGE>

         proceedings  on the part of the Company are necessary to authorize this
         Agreement or the  Registration  Rights  Agreement or for the Company to
         consummate the  transactions so contemplated  herein and therein.  This
         Agreement is, and the Registration  Rights Agreement,  when executed or
         delivered  will  be,  valid  and  binding  agreements  of the  Company,
         enforceable  against the Company in  accordance  with their  respective
         terms,  assuming  that  this  Agreement  and  the  Registration  Rights
         Agreement are valid and binding agreements of Purchaser,  subject as to
         enforcement   of  remedies  to   applicable   bankruptcy,   insolvency,
         reorganization,  moratorium  or similar laws  affecting  generally  the
         enforcement of creditors' rights and subject to a court's discretionary
         authority  with respect to the granting of a decree  ordering  specific
         performance or other equitable remedies.

                  (c) No  Violations;  Consents and  Approvals.  (i) Neither the
         execution,  delivery or performance by the Company of this Agreement or
         the Registration Rights Agreement or the consummation by the Company of
         the  transactions  contemplated  hereby or thereby (A) will result in a
         violation  or breach of the Company  Charter or the Company  By-Laws or
         the charter or by-laws of any of the Company's Subsidiaries or (B) will
         result  in a  violation  or  breach  of (or give  rise to any  right of
         termination,   revocation,   cancellation  or  acceleration   under  or
         increased payments under), or constitute a default (with or without due
         notice or lapse of time or both)  under,  or result in the  creation of
         any lien,  mortgage,  charge,  encumbrance or security  interest of any
         kind (a "Lien") upon any of the  properties or assets of the Company or
         any of its  Subsidiaries  under,  (1) any of the terms,  conditions  or
         provisions of any note, bond, mortgage, indenture, contract, agreement,
         obligation,  instrument,  offer,  commitment,  understanding  or  other
         arrangement (each a "Contract") or of any license,  waiver,  exemption,
         order,  franchise,  permit or concession (each a "Permit") to which the
         Company or any of its  Subsidiaries is a party or by which any of their
         properties or assets may be bound,  or (2) subject to the  governmental
         filings  and other  matters  referred  to in  clause  (ii)  below,  any
         judgment, order, decree, statute, law, regulation or rule applicable to
         the Company or any of its  Subsidiaries,  except, in the case of clause
         (B),  for  violations,  breaches,  defaults,  rights  of  cancellation,
         termination,  revocation  or  acceleration  or Liens  that  would  not,
         individually or in the aggregate, have a Material Adverse Effect on the
         Company and its Subsidiaries, taken as a whole.

                  (ii) Except for filings as may be  required  under,  and other
         applicable    requirements   of,   the   Hart-Scott-Rodino    Antitrust
         Improvements  Act of 1976,  as amended  (the "HSR  Act"),  no  consent,
         approval,  order or authorization  of, or registration,  declaration or
         filing with,  any  government  or any court,  administrative  agency or
         commission or other governmental authority or agency,  federal,  state,
         local or foreign (a "Governmental Entity"), is required with respect to
         the Company in connection  with the execution,  delivery or performance
         by the Company of this Agreement or the  consummation by the Company of
         the  transactions  contemplated  hereby  (except  where the  failure to
         obtain such consents,  approvals, orders or authorizations,  or to make
         such

                                        3

<PAGE>

         filings would not,  individually  or in the aggregate,  have a Material
         Adverse Effect on the Company and its Subsidiaries, taken as a whole).

                  (d) Capital Stock. The authorized capital stock of the Company
         consists  of (i)  100,000,000  shares  of  Common  Stock,  of  which an
         aggregate 29,550,646 shares of Common Stock were issued and outstanding
         as of the close of  business  on August 31,  1998,  and (ii)  5,000,000
         shares of  preferred  stock,  $.001 par value per share,  of which none
         were issued and  outstanding  as of the close of business on August 31,
         1998.  As of the close of  business  on August  31,  1998,  there  were
         outstanding  under the  Company's  stock  option  and  incentive  plans
         (collectively,  the  "Company  Stock  Plans"),  options  to  acquire an
         aggregate of 6,215,608 shares of Common Stock (subject to adjustment on
         the terms set forth therein).  All of the outstanding  shares of Common
         Stock have been duly authorized and validly issued,  and are fully paid
         and nonassessable. Except as set forth on Schedule 2.1(d), there are no
         preemptive or similar rights on the part of any holders of any class of
         securities of the Company or of any of its Subsidiaries. Except for the
         Common Stock, the Company has outstanding no bonds,  debentures,  notes
         or other  obligations or securities the holders of which have the right
         to vote (or are  convertible or  exchangeable  into or exercisable  for
         securities  having  the  right to vote)  with the  stockholders  of the
         Company on any matter. Except as set forth above or on Schedule 2.1(d),
         as of the date of this Agreement,  there are no securities  convertible
         into or exchangeable for, or options,  warrants, calls,  subscriptions,
         rights, contracts,  commitments,  arrangements or understandings of any
         kind to which the Company or any of its  Subsidiaries  is a party or by
         which  any of  them  is  bound  obligating  the  Company  or any of its
         Subsidiaries  contingently  or otherwise to issue,  deliver or sell, or
         cause to be issued,  delivered  or sold,  additional  shares of capital
         stock  or  other  voting  securities  of the  Company  or of any of its
         Subsidiaries.  Except as set  forth on  Schedule  2.1(d),  there are no
         outstanding  agreements  of the Company or any of its  Subsidiaries  to
         repurchase,  redeem or otherwise acquire any shares of capital stock of
         the Company or any of its Subsidiaries.

                  (e) Subsidiaries.  (i) Schedule 2.1(e) contains a complete and
         correct  description  of the shares of stock or other equity  interests
         that  are  authorized,  or  issued  and  outstanding,  of  each  of the
         Company's  Subsidiaries.  The  Company has no equity  interests  with a
         value of  $100,000 or more in any Person  other than its  Subsidiaries,
         and  there  are no  commitments  on the  part  of  the  Company  or any
         Subsidiary  to contribute  additional  capital in respect of any equity
         interest in any Person. Each of the outstanding shares of capital stock
         of each of the  Subsidiaries  has  been  duly  authorized  and  validly
         issued,  and is fully  paid and  nonassessable.  Except as set forth on
         Schedule 2.1(e), all of the outstanding shares of capital stock of each
         Subsidiary are owned,  either  directly or  indirectly,  by the Company
         free and clear of all Liens.

                  (ii) Schedule 2.1(e)(ii) contains a complete and correct list
         of all Subsidiaries of the Company.

                                        4

<PAGE>

                  (f) SEC  Filings.  The Company has timely  filed all  reports,
         schedules,  forms,  statements and other documents required to be filed
         by it with the SEC under the  Securities Act and the Exchange Act since
         May 1996 (the  "Company SEC  Documents").  As of its filing date,  each
         Company SEC Document filed, as amended or supplemented,  if applicable,
         (i) complied in all material respects with the applicable  requirements
         of the Securities Act or the Exchange Act, as applicable, and the rules
         and regulations  thereunder and (ii) did not, at the time it was filed,
         contain any untrue  statement  of a material  fact or omit to state any
         material  fact  required to be stated  therein or necessary to make the
         statements therein in light of the circumstances  under which they were
         made, not misleading.

                  (g) Absence of Certain Events and Changes. Except as disclosed
         in the Company SEC Documents filed with the SEC and publicly  available
         prior to the date hereof, or as otherwise  contemplated or permitted by
         this  Agreement,  and  except  for any items  referred  to in  Schedule
         2.1(g),  since June 30,  1998,  the Company and its  Subsidiaries  have
         conducted their respective businesses in the ordinary course consistent
         with  past  practice  and  there  has not been  any  event,  change  or
         development  which,  individually  or in the  aggregate,  would  have a
         Material Adverse Effect on the Company and its Subsidiaries, taken as a
         whole.

                  (h) Compliance with Applicable Law. Except as disclosed in the
         Company SEC Documents,  each of the Company and its  Subsidiaries is in
         compliance  with all statutes,  laws,  regulations,  rules,  judgments,
         orders and decrees of all Governmental  Entities  applicable to it that
         relate to its respective  business,  and neither the Company nor any of
         its Subsidiaries has received any notice alleging noncompliance except,
         with  reference  to all  the  foregoing,  where  the  failure  to be in
         compliance would not, individually or in the aggregate, have a Material
         Adverse Effect on the Company and its  Subsidiaries,  taken as a whole.
         This Section 2.1(h) does not relate to employee  benefits  matters (for
         which Section 2.1(l) is applicable,  environmental  matters, (for which
         Section  2.1(m) is applicable) or tax matters (for which Section 2.1(k)
         is  applicable).  Each  of the  Company  and its  Subsidiaries  has all
         Permits  that  are  required  in  order  to  permit  it to carry on its
         business as it is presently conducted, except where the failure to have
         such Permits or rights  would not,  individually  or in the  aggregate,
         have a Material  Adverse  Effect on the Company  and its  Subsidiaries,
         taken as a whole. All such Permits are in full force and effect and the
         Company and its  Subsidiaries  are in compliance with the terms of such
         Permits,  except where the failure to be in full force and effect or in
         compliance would not, individually or in the aggregate, have a Material
         Adverse Effect on the Company and its Subsidiaries, taken as a whole.

                  (i)  Litigation.  Except  as  disclosed  in  the  Company  SEC
         Documents  filed with the SEC and publicly  available prior to the date
         hereof or referred to in Schedule 2.1(i), there are no civil,  criminal
         or administrative actions, suits, or proceedings pending

                                        5

<PAGE>

         or, to the Knowledge of the Company, threatened, against the Company or
         any of its  Subsidiaries  that,  individually or in the aggregate,  are
         likely  to  have a  Material  Adverse  Effect  on the  Company  and its
         Subsidiaries,  taken as a whole. Except as disclosed in the Company SEC
         Documents  filed with the SEC and publicly  available prior to the date
         hereof,  there  are  no  outstanding  judgments,  orders,  decrees,  or
         injunctions  of any  Governmental  Entity against the Company or any of
         its  Subsidiaries   that,   insofar  as  can  reasonably  be  foreseen,
         individually  or in the aggregate,  in the future would have a Material
         Adverse Effect on the Company and its Subsidiaries, taken as a whole.

                  (j)  Contracts.  (i) The  Company has filed as exhibits to the
         Company SEC  Documents  all  material  agreements  required to be filed
         under the rules and regulations of the SEC (the "Material Contracts").

                  (ii) All Material Contracts are legal, valid, binding, in full
         force and effect and enforceable against each party thereto,  except to
         the extent that any failure to be  enforceable,  individually or in the
         aggregate,  would not  reasonably  be  expected  to have or result in a
         Material Adverse Effect on the Company and its Subsidiaries, taken as a
         whole, provided that no representation is made as to the enforceability
         of any  non-competition  provision in any employment  agreement.  There
         does not exist under any  Material  Contract any  violation,  breach or
         event of default,  or event or condition that, after notice or lapse of
         time or both, would constitute a violation,  breach or event of default
         thereunder,  on the part of any of the Company or its  Subsidiaries or,
         to the Knowledge of the Company or any of its  Subsidiaries,  any other
         Person,  other than such  violations,  breaches or events of default as
         would not,  individually or in the aggregate,  have a Material  Adverse
         Effect  on the  Company  and its  Subsidiaries,  taken as a whole.  The
         enforceability of all Material Contracts will not be adversely affected
         in any  manner  by the  execution,  delivery  or  performance  of  this
         Agreement or the  Registration  Rights Agreement or the consummation of
         the  transactions  contemplated  hereby  or  thereby,  and no  Material
         Contract  contains  any change in control or other terms or  conditions
         that  will  become  applicable  or  inapplicable  as a  result  of  the
         consummation  of such  transactions.  Except as set  forth on  Schedule
         2.1(j),  neither the Company  nor the  Subsidiaries  are a party to any
         contract  prohibiting  or  materially  restricting  the  ability of the
         Company or any of its  Subsidiaries to conduct its business,  to engage
         in any business or operate in any geographical area or compete with any
         person.

                  (k) Taxes. (i) Except as set forth on Schedule 2.1(k), (A) all
         Tax Returns required to be filed by or on behalf of each of the Company
         and its  Subsidiaries  have  been  filed  except to the  extent  that a
         failure to file,  individually  or in the  aggregate,  would not have a
         Material Adverse Effect on the Company and its Subsidiaries, taken as a
         whole;  (B) all such filed Tax Returns are complete and accurate in all
         respects,  other than any  incompleteness  or any inaccuracy that would
         not,  individually or in the aggregate,  have a Material Adverse Effect
         on the Company and its  Subsidiaries,  taken as a whole,  and all Taxes
         shown to be due on such Tax  Returns  have been  paid;  (C) no  written
         claim

                                        6

<PAGE>

         (other than a claim that has been  finally  settled) has been made by a
         taxing authority that any of the Company or its Subsidiaries is subject
         to an obligation to file Tax Returns or to pay or collect Taxes imposed
         by any  jurisdiction  in which  either the Company or its  Subsidiaries
         does not file Tax Returns or pay or collect Taxes,  other than any such
         claim that would not have a Material  Adverse Effect on the Company and
         its Subsidiaries, taken as a whole, or for which adequate reserves have
         been  provided  on the  balance  sheets  contained  in the  Company SEC
         Documents  filed with the SEC and publicly  available prior to the date
         hereof;  (D) there is no  deficiency  with  respect to any Taxes  which
         would, individually or in the aggregate, have a Material Adverse Effect
         on the Company and its Subsidiaries,  taken as a whole,  other than any
         such  deficiency for which adequate  reserves have been provided on the
         balance sheet contained in the financial  statements in the SEC Company
         Documents  filed with the SEC and publicly  available prior to the date
         hereof; and (E) all material  assessments for Taxes due with respect to
         completed and settled  examinations  or concluded  litigation have been
         paid which, individually or in the aggregate,  exceed $100,000. As used
         in this Agreement,  "Taxes" shall include all federal, state, local and
         foreign income,  franchise,  property,  sales,  excise and other taxes,
         tariffs or  governmental  charges of any nature  whatsoever,  including
         interest and penalties,  and additions thereto; and "Tax Returns" shall
         mean all federal  state,  local and foreign tax returns,  declarations,
         statements,  reports, schedules, forms and information returns relating
         to Taxes.

                  (ii)  Except  as set  forth on  Schedule  2.1(k),  each of the
         Company and its  Subsidiaries  has duly and timely  withheld  all Taxes
         required to be withheld in connection with its business and assets, and
         such withheld Taxes have been either duly and timely paid to the proper
         governmental  authorities  or properly  set aside in accounts  for such
         purpose,  except to the extent that any failure to do so would not have
         a Material Adverse Effect on the Company and its Subsidiaries, taken as
         a whole.

                  (iii) Except as set forth on Schedule 2.1(k),  (A) all taxable
         periods  of each of the  Company  and its  Subsidiaries  ending  before
         December 31, 1993 are closed or no longer subject to audit; (B) none of
         the Company or any of its  Subsidiaries is currently under any audit by
         any taxing  authority as to which such taxing authority has asserted in
         writing any claim which, if adversely determined, could have a Material
         Adverse Effect on the Company and its  Subsidiaries,  taken as a whole;
         and (C) no waiver  of the  statute  of  limitations  is in effect  with
         respect to any taxable year of the Company or any of its Subsidiaries.

                  (iv) Except as set forth on Schedule  2.1(k),  (A) none of the
         Company  or its  Subsidiaries  is a  party  to or  bound  by or has any
         obligation  under  any  Tax  allocation,  sharing,  indemnification  or
         similar  agreement or arrangement with any Person which might result in
         a Material  Adverse  Effect to the Company or Subsidiary  which entered
         into such agreement or arrangement;  and (B) none of the Company or its
         Subsidiaries  is or has  been at any  time a  member  of any  group  of
         companies filing a consolidated,

                                        7

<PAGE>

         combined  or unitary  income  tax return  other than any such group the
         common parent of which is the Company.

                  (l) Employee  Benefit Plans and Related  Matters;  ERISA.  (i)
         Employee  Benefit Plans.  Each Employee  Benefit Plan that provides for
         equity-based  compensation  or  that  has  associated  costs  that  are
         expected  to be  material  to the  Company or its  Subsidiaries  in the
         aggregate and that is expected to provide for  contributions to be made
         by the Company or its  Subsidiaries  or their  Employees after the date
         hereof or to permit the accrual of additional  benefits by any Employee
         of the  Company  or its  Subsidiaries  after the date  hereof is either
         listed on Schedule  2.1(l) or has been filed with the SEC as a material
         contract (collectively, the "Plans").

                  (ii) Qualification.  Except to the extent that failure to meet
         the  requirements of Section 401(a) of the Code would not result in any
         material  liability  as  to  which  adequate  reserves  have  not  been
         established,  each Employee Benefit Plan intended to be qualified under
         section  401(a)  of the Code,  and the  trust  (if any)  forming a part
         thereof, (A) has received a favorable determination letter from the IRS
         as to its qualification under the Code and to the effect that each such
         trust is exempt from  taxation  under section  501(a) of the Code,  and
         nothing has occurred since the date of such  determination  letter that
         could adversely affect such qualification or tax-exempt status or (B) a
         timely application for such a favorable  determination letter was filed
         and  the  Company  has no  reason  to  believe  that  such a  favorable
         determination letter will not be granted.

                  (iii) Compliance;  Liability.  (A) No liability has been or is
         reasonably  expected to be incurred  under or pursuant to Title I or IV
         of ERISA or the  penalty,  excise  Tax or joint and  several  liability
         provisions  of the Code  relating to employee  benefit plans that is or
         would be  material  to the  Company  and its  Subsidiaries,  taken as a
         whole.

                           (B)  Each of the  Employee  Benefit  Plans  has  been
                  operated and  administered  in all respects in compliance with
                  its terms,  all applicable laws and all applicable  collective
                  bargaining  agreements,  except  for any  failure so to comply
                  that, individually and in the aggregate,  could not reasonably
                  be expected to result in a material liability or obligation on
                  the part of the Company and its Subsidiaries in the aggregate.
                  There are no pending or  threatened  claims by or on behalf of
                  any  of  the  Employee  Benefit  Plans,  by  any  Employee  or
                  otherwise  involving  any such  Employee  Benefit  Plan or the
                  assets of any Employee Benefit Plan (other than routine claims
                  for benefits or actions seeking qualified  domestic  relations
                  orders or qualified medical child support orders, all of which
                  have been fully reserved for on the regularly prepared balance
                  sheets of the  Company  or its  Subsidiaries,  as  applicable)
                  which would  reasonably  be expected to result in any material
                  liability  to  the  Company  and  its   Subsidiaries   in  the
                  aggregate.

                                        8

<PAGE>

                           (C) Except to the extent  that it would not give rise
                  to a  material  liability  or  obligation  on the  part of the
                  Company and it Subsidiaries  in the aggregate,  no Employee is
                  or will  become  entitled to  post-employment  benefits of any
                  kind  by  reason  of  employment   with  the  Company  or  its
                  Subsidiaries,  including, without limitation, death or medical
                  benefits  (whether or not  insured),  other than (x)  coverage
                  mandated  by  section  4980B of the  Code or other  applicable
                  laws, (y) retirement benefits payable under any Plan qualified
                  under  section  401 (a) of the  Code or (z)  accrued  deferred
                  compensation.  The consummation of the transactions  hereunder
                  and under the Registration Rights Agreement will not result in
                  an increase in the amount of  compensation  or benefits or the
                  acceleration  of the  vesting  or  timing  of  payment  of any
                  compensation  or  benefits  payable  to or in  respect  of any
                  Employee by any of the Company or its Subsidiaries.

                  (iv) Employees,  Labor Matters,  etc.  Neither the Company nor
         any of its  Subsidiaries  is a  party  to or  bound  by any  collective
         bargaining   agreement,   and  there  are  no  labor  unions  or  other
         organizations  representing,  purporting  to represent or attempting to
         represent  any  employees  employed  by  the  Company  or  any  of  its
         Subsidiaries.  Since  June 30,  1998,  there has not  occurred  or been
         threatened any strike, slowdown,  picketing,  work stoppage,  concerted
         refusal to work overtime or other  similar labor  activity with respect
         to any employees of the Company or any of its  Subsidiaries.  Except as
         set forth on Schedule  2.1(l),  there are no labor  disputes  currently
         subject to any grievance procedure, arbitration or litigation and there
         is no petition  pending or  threatened  with respect to any employee of
         the  Company  or  its  Subsidiaries.   The  Company  and  each  of  its
         Subsidiaries  has complied with all applicable  laws  pertaining to the
         employment or termination of employment of their respective  employees,
         including,   without  limitation,  all  such  laws  relating  to  labor
         relations,  equal employment opportunities,  fair employment practices,
         prohibited  discrimination or distinction and other similar  employment
         activities,  except for any failure so to comply that, individually and
         in the aggregate,  could not result in a Material Adverse Effect on the
         Company and its Subsidiaries, taken as a whole.

                  (m) Environmental Matters.  Except as disclosed in the Company
         SEC Documents  filed with the SEC and publicly  available  prior to the
         date hereof and except for such matters  that,  individually  or in the
         aggregate,  would not have a Material Adverse Effect on the Company and
         its   Subsidiaries,   taken  as  a  whole,  (i)  the  Company  and  its
         Subsidiaries are in compliance with all applicable  Environmental  Laws
         (as defined  below),  (ii) the Company  and its  Subsidiaries  have all
         Permits  required under  Environmental  Laws for the operation of their
         respective businesses as presently conducted ("Environmental Permits"),
         (iii) neither the Company nor its Subsidiaries has received notice from
         any Governmental Entity asserting that either the Company or any of its
         Subsidiaries may be in violation of, or liable under, any Environmental
         Law, and (iv) there are no actions,  proceedings or claims pending (or,
         to the Knowledge of the

                                        9

<PAGE>

         Company or any of its Subsidiaries,  threatened)  seeking to impose any
         liability on Environmental  Permits or Hazardous Substances (as defined
         below).

                  For purposes of this Agreement,  "Environmental Law" means any
         federal,  state,  local or foreign law,  statute,  regulation or decree
         relating  to (x) the  protection  of the  environment  or (y) the  use,
         storage, treatment, generation,  transportation,  processing, handling,
         release or disposal of Hazardous  Substances  in each case as in effect
         on the date hereof.  "Hazardous Substance" means any waste,  substance,
         material,  pollutant or  contaminant  listed,  defined,  designated  or
         classified as hazardous, toxic or radioactive,  or otherwise regulated,
         under any Environmental Law.

                  (n) Delaware  Law. The Company has taken all action  necessary
         to ensure that the  provisions  of Section 203 of the Delaware  General
         Corporation law (the "DGCL") will not be applicable to Purchaser or its
         Affiliates  as a  result  of  the  transactions  contemplated  by  this
         Agreement.

                  (o) Status of Shares.  The Shares  being issued at the Closing
         have been duly authorized by all necessary corporate action on the part
         of the  Company,  and at Closing  such  Shares  will have been  validly
         issued and, assuming payment therefor has been made, will be fully paid
         and nonassessable,  and the issuance of such Shares will not be subject
         to  preemptive  rights of any other  stockholder  of the  Company.  The
         Shares will be eligible for listing on the Nasdaq Stock Market.

                  (p) Intellectual  Property.  The Intellectual Property that is
         owned by the Company or any of its  Subsidiaries is owned free from any
         Liens (other than Permitted Liens), except where the failure to be free
         from liens would not have a Material  Adverse Effect on the Company and
         its Subsidiaries,  taken as a whole. All material Intellectual Property
         Licenses are in full force and effect in  accordance  with their terms,
         and are free and  clear of any  Liens  (other  than  Permitted  Liens),
         except  where the  failure to be free from Liens or to be in full force
         and effect would not have a Material  Adverse Effect on the Company and
         its  Subsidiaries,  taken as a whole.  To the Knowledge of the Company,
         the conduct of the  business of the Company and its  Subsidiaries  does
         not infringe or conflict  with the rights of any third party in respect
         of any  Intellectual  Property,  except  where such  conduct  would not
         materially  affect the ability of the Company and its  Subsidiaries  to
         conduct their business as presently conducted.  To the Knowledge of the
         Company,  none of the Company Intellectual  Property is being infringed
         by any third  party  except  where such  infringement  would not have a
         Material  Adverse  Effect on Company and its  Subsidiaries,  taken as a
         whole.  There is no claim or demand of any Person pertaining to, or any
         proceeding  which is  pending  or,  to the  Knowledge  of the  Company,
         threatened,  that  challenges  the rights of the  Company or any of its
         Subsidiaries in respect of any Company Intellectual  Property,  or that
         claims that any default exists under any Intellectual Property License,
         except  where such claim,  demand or  proceeding  would not  materially
         affect the ability of the Company and its Subsidiaries to conduct

                                       10

<PAGE>

         their business as presently conducted.  For purposes of this Agreement,
         "Company Intellectual Property" means the Intellectual Property that is
         owned by the Company and its Subsidiaries and the Intellectual Property
         subject  to  written  or  oral  licenses,  agreements  or  arrangements
         pursuant to which its use by the Company or any of its  Subsidiaries is
         permitted by any Person.

                  (q) Brokers or Finders. No agent, broker, investment banker or
         other firm is or will be  entitled to any  broker's or finder's  fee or
         any other  commission  or  similar  fee in  connection  with any of the
         transactions contemplated by this Agreement.

         Section 2.2       Representations and Warranties of Purchaser.

         Purchaser hereby represents and warrants to the Company as follows:

         (a) Organization. Purchaser is a corporation duly organized and validly
existing and in good standing under the laws of the Federal Republic of Germany,
with all requisite  power and authority to own, lease and operate its properties
and to conduct its business as now being conducted.

         (b)  Authority.   Purchaser  has  the  requisite  corporate  power  and
authority to execute,  deliver and perform its obligations  under this Agreement
and  to  consummate  the  transactions  contemplated  hereby  and  thereby.  All
necessary  corporate  action  required  to have  been  taken by or on  behalf of
Purchaser by applicable  law or otherwise to authorize the approval,  execution,
delivery and  performance  by Purchaser of this  Agreement and the  Registration
Rights  Agreement and the  consummation by it of the  transactions  contemplated
hereby and thereby have been duly  authorized,  and no other  proceedings on its
part are or will be necessary to authorize  this  Agreement or the  Registration
Rights Agreement or for it to consummate such  transactions.  This Agreement is,
and the  Registration  Rights  Agreement,  when executed and delivered  will be,
valid and binding  agreements of  Purchaser,  enforceable  against  Purchaser in
accordance  with their  respective  terms,  assuming that this Agreement and the
Registration  Rights Agreement are valid and binding  agreements of the Company,
subject as to  enforcement  of remedies to  applicable  bankruptcy,  insolvency,
reorganization,  moratorium or similar laws affecting  generally the enforcement
of  creditors'  rights and  subject to a court's  discretionary  authority  with
respect to the  granting  of a decree  ordering  specific  performance  or other
equitable remedies.

         (c) Conflicting Agreements and Other Matters. Neither the execution and
delivery  of  this  Agreement  or the  Registration  Rights  Agreement  nor  the
performance  by  Purchaser  of its  obligations  hereunder  or  thereunder  will
conflict  with,  result in a breach of the terms,  conditions or provisions  of,
constitute a default  under,  result in the creation of any Lien upon any of the
properties or assets of Purchaser pursuant to, or require any consent,  approval
or other  action  by or any  notice  to or  filing  with any  Government  Entity
pursuant  to, the  organizational  documents or  agreements  of Purchaser or any
agreement, instrument, order, judgment, decree, statute, law, rule or regulation
by which Purchaser is bound (assuming that the Company shall have made or

                                       11

<PAGE>

obtained all consents,  approvals, orders, authorizations or filings referred to
in Section 2.1(c)(ii)), except for filings after the Closing under Section 13(d)
of the Exchange Act and filings under the HSR Act.

         (d) Acquisition  for Investment.  (i) Purchaser is acquiring the Shares
for its own account for the purpose of investment  and not with a view to or for
sale in connection with any distribution  thereof,  and Purchaser has no present
intention  to  effect,   or  any  present  or  contemplated   plan,   agreement,
undertaking, arrangement, obligation, indebtedness, or commitment providing for,
any  distribution  of Shares,  (ii)  Purchaser  is an  "accredited  investor" as
defined in Rule 501(a) under the Securities  Act, (iii)  Purchaser has carefully
reviewed the representations  concerning the Company contained in this Agreement
and has made  detailed  inquiry  concerning  the  Company,  its business and its
personnel, and (iv) Purchaser has sufficient knowledge and experience in finance
and  business  that it is  capable  of  evaluating  the risks and  merits of its
investment in the Company and is able financially to bear the risks thereof.

         (e) Brokers or  Finders.  Except as set forth on  Schedule  2.2(e),  no
agent,  broker,  investment  banker or other firm is or will be  entitled to any
broker's or finder's fee or any other  commission or similar fee from  Purchaser
in connection with any of the transactions contemplated by this Agreement


                                   ARTICLE III

                        EQUITY PURCHASES FROM THE COMPANY

         Section 3.1 Subscription Rights. So long as Purchaser has not sold more
than 1,000,000 Shares (as adjusted to reflect any stock splits,  stock dividends
and similar recapitalizations) (other than sales to Affiliates),  if the Company
proposes the issuance of New Securities  (other than any New  Securities  issued
(i) to officers, employees, directors, consultants or advisors of the Company or
any of its  Subsidiaries  pursuant  to any  employee  stock  offering,  plan  or
arrangement,  (ii) in connection with any acquisition of another  corporation by
the  Company  by  merger,   purchase  of  all  or  substantially   all  of  such
corporation's   assets  or  other   reorganization   (iii)  in  connection  with
Pharmaceutical  Alliances,  (iv) in  connection  with  Research and  Development
Funding  Transactions,  (v) in connection  with  equipment  leasing or equipment
financing arrangements,  to the Person who leased or financed such equipment and
(vi) to Purchaser or its  Affiliates)  then,  prior to each such issuance of New
Securities,  the Company  shall offer to  Purchaser a Pro Rata Share of such New
Securities. Any offer of New Securities made to Purchaser under this Section 3.1
shall be made by notice in writing (the "Subscription Notice"). The Subscription
Notice shall set forth (i) the number of New Securities proposed to be issued to
Persons  other than  Purchaser  and the terms of such New  Securities,  (ii) the
consideration  (or manner of determining the  consideration),  if any, for which
such New  Securities  are proposed to be issued and the terms of payment,  (iii)
the  number of New  Securities  offered  to  Purchaser  in  compliance  with the
provisions of this Section 3.1 and (iv) the proposed


                                       12

<PAGE>

date of issuance of such New  Securities.  Not later than 20 Business Days after
its receipt of a  Subscription  Notice,  Purchaser  shall  notify the Company in
writing  whether it elects to purchase all or any portion of the New  Securities
offered to Purchaser  pursuant to the  Subscription  Notice.  If Purchaser shall
elect to purchase any such New  Securities,  the New  Securities  which it shall
have elected to purchase shall be issued and sold to Purchaser by the Company at
the same time and on the same terms and  conditions  as the New  Securities  are
issued and sold to any other  Person.  If, for any reason,  the issuance of such
New Securities is not  consummated,  Purchaser's  right to its Pro Rata Share of
such issuance shall lapse,  subject to Purchaser's  ongoing  subscription  right
with respect to issuances of New Securities at later dates or times.

         Section 3.2 Issuance and Delivery of New  Securities  and Voting Stock.
The Company  represents and covenants to Purchaser  that (i) upon issuance,  all
the shares of New  Securities  sold to  Purchaser  pursuant to this  Article III
shall be duly authorized, validly issued, fully paid and nonassessable and shall
be approved (if  outstanding  securities  of the Company of the same type are at
the time  already  approved  and the New  Securities  are  registered  under the
Securities  Act) for  listing on the Nasdaq  Stock  Market or for  quotation  or
listing on the principal trading market for the securities of the Company at the
time of  issuance,  (ii) upon  delivery of such  shares,  they shall be free and
clear of all  claims  and Liens of any  nature  and shall not be  subject to any
preemptive  right of any stockholder of the Company and (iii) in connection with
any such  issuance,  the Company  shall take such  actions as are  specified  in
Section  2.1(o) with respect to such  shares.  Each share issued or delivered by
the Company hereunder shall bear the legends set forth in Section 11.10.

         Section  3.3  Termination  of  Article  III.  This  Article  III  shall
terminate  upon the  earlier  of (i) a sale of all or  substantially  all of the
assets or business of the Company,  by merger,  sale of assets or otherwise,  or
(ii) termination of the Program Term.


                                   ARTICLE IV

            LIMITATIONS ON PURCHASES OF ADDITIONAL EQUITY SECURITIES

         Section  4.1  Purchases  of Equity  Securities.  (a) Prior to the third
anniversary of the Closing,  except as permitted by Section 4.1(b),  (c) or (d),
Purchaser and its  Affiliates  will not (and will not assist or encourage  other
to) directly or indirectly in any manner:

                           (i)      acquire, or agree to acquire, directly or
indirectly, alone or in concert with others, by purchase, gift or otherwise, any
direct or indirect beneficial  ownership (within the meaning of Rule 13d-3 under
the Exchange Act) or interest in any  securities  or direct or indirect  rights,
warrants or options to acquire,  or securities  convertible into or exchangeable
for, any securities of the Company;

                           (ii)     make, or in any way participate in, directly
 or indirectly, alone or

                                       13

<PAGE>

in concert with others,  any  "solicitation" of "proxies" to vote (as such terms
are used in the proxy rules of the SEC promulgated pursuant to Section 14 of the
Exchange Act); provided, however, that the prohibition in this subparagraph (ii)
shall not apply to solicitations  exempted from the proxy  solicitation rules by
Rule  14a-2  under  the  Exchange  Act as such  Rule is in effect as of the date
hereof.

                           (iii)    form, join or in any way participate in a
"group" within the meaning of Section 13(d)(3) of the Exchange Act with respect 
to any voting securities of the Company; or

                           (iv)     acquire or agree to acquire, directly or 
indirectly, alone or in concert with others, by purchase, exchange or otherwise,
(i) any of the assets, tangible or intangible, of the Company or (ii) direct or
indirect rights, warrants or options to acquire any assets of the Company, 
except for such assets as are then being offered for sale by the Company;

                           (v)      enter into any arrangement or understanding
with others to do any of the actions restricted or prohibited under clauses (i),
(ii) or (iii) of this Section 4.1(a); or

                           (vi)     otherwise act in concert with others, to 
seek to offer to the Company or any of its stockholders any business 
combination,  restructuring, recapitalization or similar transaction to or with 
the Company or otherwise seek in concert with others, to control, change or 
influence the management, board of directors or policies of the Company or 
nominate any person as a director of the Company who is not  nominated by the 
then incumbent directors, or propose any matter to be voted upon by the 
stockholders of the Company; provided, however, that nothing in this 
subparagraph (vi) shall prevent Purchaser or any Affiliate of Purchaser, either
acting alone or in concert with each other, from taking any action..

                  (b) Nothing herein shall prevent Purchaser from purchasing any
securities  of the Company  pursuant to the terms of this  Agreement  (including
through exercise of its rights under Section 3.1 hereof) and Purchaser shall not
be treated as having breached any covenant in this Agreement  solely as a result
of such purchase.

                  (c) Nothing  herein shall prevent  Purchaser  from  purchasing
additional  Equity  Securities of the Company if (i) prior thereto Purchaser has
not sold any Shares  (other than to an  Affiliate of  Purchaser)  and (ii) after
such purchase  Purchaser and its Affiliates  would own fourteen and three-tenths
percent  (14.3%) or less of the Total Voting Power of all Voting  Securities  of
the Company then outstanding.

                  (d) This Section 4.1 shall  terminate  and  Purchaser  and its
Affiliates shall have the right to acquire any securities of the Company without
regard to the  limitation  on share  ownership  set forth in Section  4.1 in the
event that:

                                       14

<PAGE>


                   (i) the Company has entered into (A) a merger agreement in
which the holders of the Company's Voting Securities would cease to hold a 
majority of the voting securities of the surviving corporation, (B) an agreement
to sell all or substantially all its assets, or (C) an agreement to be acquired,
business combination, consolidation or any such similar transaction,  in each
case with any Person  other  than a  wholly-owned  subsidiary  of the  Company;
provided, however, the limitation shall continue if (i) the merger agreement is
with a majority-owned subsidiary of the Company and the Company is to be the
surviving corporation in the merger, or (ii) the merger  agreement  or other
agreements referred to in sections (A), (B), or (C) is subsequently terminated 
or the transactions contemplated thereunder are not consummated; or

                  (ii) a tender  or  exchange  offer  (other  than a  tender  or
exchange  offer  that  the  Company's  Board of  Directors  has  recommended  be
rejected)  is made by any Person or 13D Group (as  hereinafter  defined)  (other
than an  Affiliate  of, or any Person  acting in  concert  with,  Purchaser)  to
acquire  Voting  Securities  which,  if added to the Voting  Securities (if any)
already  owned by such Person or 13D Group,  would  result,  if  consummated  in
accordance  with its terms,  in the  Beneficial  Ownership by such Person or 13D
Group of more than 30% of the Total Voting Power of all Voting Securities of the
Company then  outstanding,  provided that the limitation  shall be reinstated if
such tender or exchange offer is withdrawn or terminated  without such Person or
13D Group acquiring such 30% ownership level; or

                 (iii) it is publicly disclosed or Purchaser otherwise  learns
that Voting Securities representing  more than 35% of the Total Voting Power of
all Voting Securities of the Company then outstanding are Beneficially Owned by
any Person or 13D Group (other than an Affiliate of, or any person acting in 
concert with, Purchaser); or

                 (iv) a proxy contest (or similar incident) is made by any 
Person of 13D Group  (other  than an  Affiliate  of, or any  Person  acting in 
concert with, Purchaser) to elect individuals who at the beginning of any 
calendar year did not constitute  the  majority of the members of the Board of 
Directors  of the Company then in office and the  Purchaser,  upon the advice of
legal counsel and financial  advisors,  reasonably believes in good faith, that 
such proxy contest will result in the election of individuals who will 
constitute a majority of members of the Board of Directors of the Company,  but
who did not, at the beginning of the calendar  year,  constitute  the majority
of the members of the Board of Directors of the Company then in office, provided
that the limitation shall be reinstated if such proxy contest or similar 
incident is terminated or withdrawn without affecting the change in the Board of
Directors referred to above.

         (e) As used  herein,  the term  "13D  Group"  shall  mean any  group of
Persons  formed for the purpose of  acquiring,  holding,  voting or disposing of
Voting  Securities  which would be required  under Section 13(d) of the Exchange
Act and the  rules and  regulations  thereunder  (as now in effect  and based on
present legal interpretations  thereof) to file a statement on Schedule 13D with
the SEC as a "person"  within the meaning of Section  13(d)(3)  of the  Exchange
Act.  Ownership  of Voting  Securities  under  Section  4.1(d) above and Section
5.1(d) below shall be determined  in accordance  with Rule 13d-3 of the Exchange
Act as currently in effect.


                                       15
<PAGE>


                                    ARTICLE V

                            TRANSFER OF COMMON STOCK

         Section  5.1  Limitations on Transfer. (a) Prior to the second 
anniversary of the Closing, Purchaser will not, directly or  indirectly,  sell,
transfer or otherwise dispose of any Shares (except to any Affiliate of
Purchaser).

         (b)  After  the  second  anniversary  of the  Closing  and prior to the
expiration  of the Program Term,  Purchaser  will not,  directly or  indirectly,
sell,  transfer or  otherwise  dispose of, in any one calendar  year,  more than
2,500,000  Shares (as adjusted to reflect any stock splits,  stock dividends and
similar recapitalizations) (except to an Affiliate of Purchaser).

         (c) (i) After the second  anniversary  of the  Closing and prior to the
expiration of the Program  Term, if Purchaser  proposes to sell any Shares other
than pursuant to a registration  statement under the Securities Act, the Company
shall have a right of first negotiation with respect to the acquisition of those
Shares proposed to be sold. Said right of first  negotiation must be asserted by
the Company  within  fifteen (15) Business Days of its receipt of written notice
from  Purchaser of its  intention  to sell any Shares  other than  pursuant to a
registration  statement  under the Securities Act. Such notice shall specify the
general terms and conditions on which Purchaser  intends to sell such Shares. If
the Company and Purchaser are unable to agree on the terms and conditions of the
Company's  acquisition  of such Shares  within  fifteen  (15)  Business  Days of
Purchaser's  notification  to the  Company  of its  intention  to  sell  Shares,
Purchaser may sell such Shares at any time within the next 120 days on terms and
conditions no more favorable,  taken as a whole, than those originally  proposed
to the Company.  (ii) After the second  anniversary  of the Closing and prior to
the  expiration of the Program  Term,  if Purchaser  proposes to sell any Shares
pursuant to a registration statement under the Securities Act, the Company shall
have a right of first  negotiation  with  respect  to the  acquisition  of those
Shares proposed to be sold. Said right of first  negotiation must be asserted by
the Company  within  fifteen (15) Business Days of its receipt of written notice
from  Purchaser of its intention to sell any Shares  pursuant to a  registration
statement under the Securities Act. Such notice shall specify the price for such
Shares,  which shall be equal to the average  closing  price of the Common Stock
over the 30-day  period  ending on the date of such notice.  If the Company does
not agree to purchase  such Shares at such price within  fifteen  (15)  Business
Days of Purchaser's notification to the Company of its intention to sell Shares,
Purchaser  may sell such Shares at any time within the next 180 days pursuant to
a  registration  statement  without  restriction  as to the price at which  such
Shares may be sold.

                  (d) The limitation on share transfer set forth in this Section
5.1 shall  terminate  and  Purchaser  and its  Affiliates  shall have the right,
directly or  indirectly,  to sell,  transfer or otherwise  dispose of any Shares
without regard to any limitation on share transfer set forth in


                                       16

<PAGE>


Section 5.1 in the event that:

                  (i) the  Company has entered  into (A) a merger  agreement  in
which the holders of the Voting Securities would cease to hold a majority of the
voting securities of the surviving corporation,  (B) an agreement to sell all or
substantially  all its assets,  or (C) an  agreement  to be  acquired,  business
combination,  consolidation or any such similar  transaction,  in each case with
any Person  other  than a  wholly-owned  subsidiary  of the  Company;  provided,
however, the limitation shall (1) continue if (x) the merger agreement is with a
majority-owned  subsidiary of the Company and the Company is to be the surviving
corporation  in the merger or (y) the majority of the  directors of the Company,
who have held that  position  for at least nine (9) months prior to the entering
into of the merger agreement  continue as the directors of the surviving company
after  the  merger  or (2) be  reinstated  if such  merger  agreement  or  other
agreements referred to in sections (A), (B) or (C) is subsequently terminated or
the transactions contemplated thereunder are not consummated;

                  (ii) a tender  or  exchange  offer  (other  than a  tender  or
exchange  offer  that  the  Company's  Board of  Directors  has  recommended  be
rejected) is made by any Person or 13D Group (other than an Affiliate of, or any
Person acting in concert with, Purchaser) to acquire Voting Securities which, if
added to the Voting  Securities  (if any)  already  owned by such  Person or 13D
Group,  would  result,  if  consummated  in  accordance  with its terms,  in the
Beneficial  Ownership  by such Person or 13D Group of more than 50% of the Total
Voting Power of all Voting Securities of the Company then outstanding,  provided
that the  limitation  shall be  reinstated  if such tender or exchange  offer is
withdrawn  or  terminated  without such Person or 13D Group  acquiring  such 50%
ownership level; or

                  (iii) a tender or exchange offer, which the Company's Board of
Directors  has not approved or  recommended,  is made by any Person or 13D Group
(other than an Affiliate of, or any Person acting in concert with, Purchaser) to
acquire  Voting  Securities  which,  if added to the Voting  Securities (if any)
already  owned by such Person or 13D Group,  would  result,  if  consummated  in
accordance  with its terms,  in the  Beneficial  Ownership by such Person or 13D
Group of more than 50% of the Total Voting Power of all Voting Securities of the
Company then outstanding and the Purchaser, upon the advice of legal counsel and
financial  advisors,  reasonably believes in good faith, taking into account the
conditions  of the offer,  that such  tender or  exchange  offer will  result in
Voting  Securities  being  purchased,  provided  that  the  limitation  shall be
reinstated if such tender or exchange  offer is withdrawn or terminated  without
such Person or 13D Group acquiring such 50% ownership level.


                                       17

<PAGE>

                                   ARTICLE VI

                       COVENANTS AND ADDITIONAL AGREEMENTS

         Section 6.1  Ordinary  Course.  During the period from the date of this
Agreement and continuing until the Closing,  the Company agrees as to itself and
its  Subsidiaries  that,  except as set forth in Schedule  6.1, or to the extent
that Purchaser  otherwise consents in writing,  the Company and its Subsidiaries
shall  conduct   their   respective   businesses  in  the  ordinary   course  in
substantially the same manner as presently conducted.

         Section 6.2 Access and Information.  So long as this Agreement  remains
in effect,  prior to the  Closing,  the Company will (and will cause each of its
Subsidiaries and each of their  respective  accountants,  counsel,  consultants,
officers,  directors,  employees, agents and representatives of or to any of the
Subsidiaries,  to) give  Purchaser and its  Representatives,  reasonable  access
during reasonable business hours to all of their respective properties,  assets,
books,  contracts,   reports  and  records  relating  to  the  Company  and  its
Subsidiaries,  and furnish to them all such  documents,  records and information
with  respect to the  properties,  assets and  business  of the  Company and its
Subsidiaries,  as  Purchaser  shall from time to time  reasonably  request.  The
Company will keep Purchaser generally informed as to the business of the Company
and its Subsidiaries.

         Section 6.3  Further  Actions.  (a) Each of the  Company and  Purchaser
shall use reasonable best efforts to take or cause to be taken all actions,  and
to do or cause to be done all other  things,  necessary,  proper or advisable in
order to fulfill and perform its  obligations  in respect of this  Agreement and
the Registration Rights Agreement, or otherwise to consummate and make effective
the transactions contemplated hereby and thereby.

         (b)  Each  of  the  Company  and  Purchaser   shall,   as  promptly  as
practicable,  (i)  make,  or cause  to be  made,  all  filings  and  submissions
(including but not limited to under the HSR Act and foreign  antitrust  filings)
required  under any law  applicable to it or any of its  Subsidiaries,  and give
such  reasonable  undertakings as may be required in connection  therewith,  and
(ii) use all  reasonable  efforts to obtain or make,  or cause to be obtained or
made,  all  Permits  necessary  to be  obtained  or  made  by it or  any  of its
Subsidiaries,   in  each  case  in  connection   with  this  Agreement  and  the
Registration  Rights  Agreement,  the sale and  transfer of the Shares  pursuant
hereto and the  consummation of the other  transactions  contemplated  hereby or
thereby.

         (c) Each of the Company and Purchaser  shall  coordinate  and cooperate
with  the  other  party  in  exchanging  such  information  and  supplying  such
reasonable  assistance  as may be  reasonably  requested  by such other party in
connection with the filings and other actions contemplated by this Agreement and
the Registration Rights Agreement.

                                       18

<PAGE>

         (d) At all times prior to the Closing  Date,  the Company and Purchaser
shall  promptly  notify each other in writing of any fact,  condition,  event or
occurrence that could  reasonably be expected to result in the failure of any of
the conditions contained in Article VII to be satisfied,  promptly upon becoming
aware of the same.

         Section 6.4 Further Assurances. Following the Closing Date, the Company
shall,  from time to time,  execute and  deliver  such  additional  instruments,
documents,  conveyances  or  assurances  and take such other actions as shall be
necessary,  or otherwise  reasonably be requested by  Purchaser,  to confirm and
assure  the  rights  and  obligations  provided  for in this  Agreement  and the
Registration  Rights  Agreement  and render  effective the  consummation  of the
transactions  contemplated  hereby and  thereby,  or  otherwise to carry out the
intent and purposes of this Agreement.

         Section 6.5 Board  Attendance  Rights and Rights to  Information  about
Board and the  Company.  (a) The Company  shall permit a  Representative  (which
Representative  shall be  designated  by  Purchaser)  to attend two (2)  regular
meetings of the Company's  Board of Directors  each year during the Program Term
(one such  meeting to be held  between  January  and June of each year,  and the
second  such  meeting  to be held  between  July  and  December  of each  year);
provided,  however,  that,  at  the  request  of the  Board  of  Directors,  the
Representative  shall excuse  himself or herself from such portions of the Board
of Directors  meeting that he or she is attending if the Board of Directors  and
its legal counsel believe it to be necessary so to conduct the Board's  business
(i) in order to avoid  conflict with the Company's  obligations to third parties
(such  as,  but  not  limited  to,   discussions  of   proprietary   aspects  of
collaborations with third parties),  (ii) discussions of disputes with Purchaser
and/or  its  Affiliates,  and  (iii)  any  other  matters  in which the Board of
Directors  and such legal counsel  reasonably  conclude that the exercise of the
fiduciary  duties of the Board of  Directors  requires  such  Representative  to
excuse himself or herself.

         (b) The Company shall  provide to the  Purchaser  copies of agendas for
all  Board  meetings  prior  to such  meetings  and the  minutes  for all  Board
meetings,  including meetings of committees of the Board, as soon as practicable
after the conclusion of any such meeting.

         (c) Once during each calendar quarter,  at the request of Purchaser,  a
Representative  (which  Representative shall be designated by Purchaser) will be
entitled  to  receive a  confidential  briefing  from  officers  of the  Company
concerning the Company's business and strategy, including a report on the status
of the Discovery Program and the Company's other collaborative  programs (to the
extent not precluded by the terms and  conditions  under any such  collaboration
program) and the Company's consolidated corporate strategic overview.


                                   ARTICLE VII

                              CONDITIONS PRECEDENT


                                       19

<PAGE>

         Section 7.1 Each Party's  Obligations.  The  obligations of the Company
and  Purchaser  to  consummate  the  transactions  contemplated  to occur at the
Closing shall be subject to the satisfaction prior to the Closing of each of the
following  conditions,  each  of  which  may be  waived  only  if it is  legally
permissible to do so:

         (a) HSR and Other  Approvals.  Any applicable  waiting period under the
HSR Act relating to the transactions  contemplated  hereby shall have expired or
been  terminated,  and all other material  authorizations,  consents,  orders or
approvals of, or  regulations,  declarations  or filings with, or expirations of
applicable  waiting  periods  imposed by, any  Governmental  Entity  (including,
without limitation, any foreign antitrust filing) necessary for the consummation
of the transactions  contemplated  hereby,  shall have been obtained or filed or
shall have occurred.

         (b) No  Litigation,  Injunctions,  or  Restraints.  No  statute,  rule,
regulation, executive order, decree, temporary restraining order, preliminary or
permanent injunction or other order enacted, entered.  promulgated,  enforced or
issued  by any  Governmental  Entity or other  legal  restraint  or  prohibition
preventing the consummation of the  transactions  contemplated by this Agreement
and the Registration Rights Agreement shall be in effect.

         (c) Collaboration  Agreement.  The  Collaboration  Agreement shall have
become effective in accordance with the terms and conditions thereof.

         (d) Nasdaq Listing.  The Shares shall have been approved for listing on
the Nasdaq Stock Market, subject only to official notice of issuance.

         Section  7.2  Conditions  to  the  Obligations  of  the  Company.   The
obligations of the Company to consummate the transactions  contemplated to occur
at the Closing shall be subject to the  satisfaction  or waiver thereof prior to
the Closing of each of the following conditions:

         (a) Representations and Warranties.  The representations and warranties
of Purchaser that are qualified as to materiality shall be true and correct, and
those  that  are not so  qualified  shall be true and  correct  in all  material
respects,  as of the date of this Agreement and as of the time of the Closing as
though made at and as of such time,  except to the extent  such  representations
and  warranties  expressly  relate  to an  earlier  date  (in  which  case  such
representations  and warranties  that are qualified as to  materiality  shall be
true and correct,  and those that are not so qualified shall be true and correct
in all material respects,  on and as of such earlier date) and the Company shall
have received a certificate signed by an authorized officer of Purchaser to such
effect.

         (b) Registration  Rights  Agreement.  Purchaser shall have executed and
delivered the Registration Rights Agreement.

         Section  7.3  Conditions to the Obligations of Purchaser.  The 
obligations of Purchaser to consummate the transactions contemplated to occur at
the Closing shall be subject to the 

                                       20

<PAGE>

satisfaction or waiver thereof prior to the Closing of each of the following 
conditions:

         (a) Representations and Warranties.  The representations and warranties
of the Company set forth in this  Agreement that are qualified as to materiality
shall be true and correct, and those that are not so qualified shall be true and
correct in all material respects, as of the date of this Agreement and as of the
time of the Closing as though made at and as of such time,  except to the extent
such  representations  and  warranties  expressly  relate to an earlier date (in
which  case  such  representations  and  warranties  that  are  qualified  as to
materiality shall be true and correct, and those that are not so qualified shall
be true and correct in all material  respects,  on and as of such earlier date),
and Purchaser  shall have received a certificate  signed by the chief  executive
officer and chief financial officer of the Company to such effect.

         (b) Opinion of the Company's Counsel. Purchaser shall have received the
opinion  dated as of the Closing of Hale and Dorr,  counsel to the  Company,  in
form and substance reasonably satisfactory to Purchaser.

         (c) Registration Rights Agreement.  The Company shall have executed and
delivered the Registration Rights Agreement.

         (d)  Performance of Obligations of the Company.  The Company shall have
performed  or  complied  in all  material  respects  with  all  obligations  and
covenants  required to be performed or complied  with by the Company  under this
Agreement  and the Purchaser  shall have  received a  certificate  signed by the
chief  executive  officer  and chief  financial  officer of the  Company to such
effect.

         (e) Corporate Proceedings.  All corporate proceedings of the Company in
connection  with  the  transactions  contemplated  by  this  Agreement  and  the
Registration  Rights  Agreement,  and all  documents  and  instruments  incident
thereto,  shall be  satisfactory  in form and  substance  to  Purchaser  and its
counsel,  and Purchaser  and its counsel shall have received all such  documents
and instruments, or copies thereof, certified or requested, as may be reasonably
requested.


                                  ARTICLE VIII

                                   TERMINATION

         Section 8.1 Termination.  This Agreement may be terminated at any time
prior to the Closing:

                  (a)  by mutual written consent of Purchaser and the Company;

                  (b)  by Purchaser or the Company;



                                       21

<PAGE>

                      (i) if the  Closing  shall  not  have  occurred  prior  to
                  December 31, 1998, provided,  that the right to terminate this
                  Agreement  pursuant to this clause (i) shall not be  available
                  to any party  whose  failure to fulfill any  obligation  under
                  this Agreement results in the failure of the Closing to occur;

                      (ii) if there shall be any  statute,  law,  regulation  or
                  rule that makes  consummating  the  transactions  contemplated
                  hereby illegal or if any court or other Governmental Entity of
                  competent  jurisdiction  shall have issued a judgment,  order,
                  decree or  ruling,  or shall  have  taken  such  other  action
                  restraining,    enjoining   or   otherwise   prohibiting   the
                  consummation of the transactions  contemplated hereby and such
                  judgment,  order, decree or ruling shall have become final and
                  non-appealable; or

                      (iii)   if  the   Collaboration   Agreement   shall   have
terminated;

                  (c)  by Purchaser:

                      (i) if the  Company  shall  have  failed to perform in any
                  material  respect any of its  obligations  hereunder  or shall
                  have  breached in any respect any  representation  or warranty
                  contained  herein  qualified  by  materiality  or  shall  have
                  breached  in  any  material  respect  any   representation  or
                  warranty  not so  qualified,  and the  Company  has  failed to
                  perform such obligation or cure such breach, within 30 days of
                  its receipt of written notice thereof from Purchaser, and such
                  failure to perform  shall not have been  waived in  accordance
                  with the terms of this Agreement; or

                      (ii) if any of the  conditions set forth in Section 7.1 or
                  7.3 shall become impossible to fulfill (other than as a result
                  of any breach by Purchaser of the terms of this Agreement) and
                  shall not have been  waived  in  accordance  with the terms of
                  this Agreement;

                  (d)  by the Company:

                      (i) if  Purchaser  shall  have  failed to  perform  in any
                  material  respect any of its  obligations  hereunder  or shall
                  have  breached in any respect any  representation  or warranty
                  contained  herein  qualified  by  materiality  or  shall  have
                  breached any material respect any  representation  or warranty
                  not so  qualified,  and  Purchaser  has failed to perform such
                  obligation or cure such breach,  within 30 days of its receipt
                  of written notice  thereof from the Company,  and such failure
                  to perform shall not have been waived in  accordance  with the
                  terms of this Agreement; or

                      (ii) if any of the  conditions set forth in Section 7.1 or
                  7.2 shall become impossible to fulfill (other than as a result
                  of any breach by the Company of the


                                       22

<PAGE>

                  terms of this Agreement) and shall not have been waived in 
                  accordance with the terms of this Agreement;

         Section 8.2 Effect of Termination.  In the event of termination of this
Agreement by either the Company or  Purchaser  as provided in Section 8.1,  this
Agreement shall forthwith become void and have no effect,  without any liability
or obligation on the part of Purchaser or the Company, other than the provisions
of this Section  8.2,  Section 11.9 and Article IX and except to the extent that
such termination  results from the willful and material breach by a party of any
of its  representations,  warranties,  covenants or agreements set forth in this
Agreement.


                                   ARTICLE IX

                                 INDEMNIFICATION

         Section 9.1  Indemnification  of Purchaser.  The Company  covenants and
agrees to defend,  indemnify and hold harmless each of Purchaser, its Affiliates
(other  than the  Company  and any of its  Subsidiaries),  and their  respective
officers,  directors,  partners, employees, agents, advisers and representatives
(collectively,  the  "Purchaser  Indemnities")  from  and  against,  and  pay or
reimburse  the  Purchaser   Indemnitees  for,  any  and  all  claims,   demands,
liabilities,  obligations,  losses, costs,  expenses,  fines or damages (whether
absolute,  accrued,  conditional  or otherwise and whether or not resulting from
third party claims),  including  interest and penalties with respect thereto and
all expenses  incurred in the  investigation or defense of any of the same or in
asserting,  preserving or enforcing  any of their  respective  rights  hereunder
(collectively,  "Losses"),  resulting  from or based on (or allegedly  resulting
from or based on) any  breach by the  Company of any  representation,  warranty,
covenant or obligation of the Company  hereunder.  The Losses  described in this
Section 9.1 are herein  referred to as  "Purchaser  Indemnifiable  Losses".  The
Company  shall  reimburse  the  Purchaser  Indemnitees  for any  legal  or other
expenses incurred by such Purchaser Indemnitees in connection with investigating
or  defending  any such  Purchaser  Indemnifiable  Losses as such  expenses  are
incurred.

         Section 9.2  Indemnification  Procedures.  Promptly  after receipt by a
Purchaser  Indemnitee of notice of the commencement of any action or the written
assertion of any claim,  such Purchaser  Indemnitee shall, if a claim in respect
thereof is to be made against the Company, as the case may be (the "Indemnifying
Person"),  notify the Indemnifying  Person in writing of the commencement or the
written assertion  thereof.  Failure by a Purchaser  Indemnitee to so notify the
Indemnifying Person shall relieve the Indemnifying Person from the obligation to
indemnify such  Purchaser  Indemnitee  only to the extent that the  Indemnifying
Person suffers actual and material  prejudice as a result of such failure but in
no event shall such  failure to notify the  Indemnifying  Person (i)  constitute
prejudice  suffered  by the  Indemnifying  Person if it has  otherwise  received
notice of the  actions  giving  rise to such  obligation  to  indemnify  or (ii)
relieve it from any liability or obligation  that it may otherwise  have to such
Purchaser  Indemnitee.  In case any such  action or claim  shall be  brought  or
asserted against any Purchaser Indemnitee and

                                       23

<PAGE>

it shall  notify  the  Indemnifying  Person  of the  commencement  or  assertion
thereof,  the Indemnifying  Person shall be entitled to participate  therein but
the  defense  of such  action or claim  shall be  conducted  by  counsel  to the
Purchaser Indemnitee, provided, however, that the Indemnifying Person shall not,
in  connection   with  any  one  such  action  or  proceeding  or  separate  but
substantially  similar  actions or  proceedings  arising out of the same general
allegations,  be liable for the fees and expenses of more than one separate firm
of attorneys  at any time for all  Purchaser  Indemnitees,  except to the extent
that local  counsel,  in  addition to regular  counsel,  is required in order to
effectively defend against such action or proceeding and provided further that a
Purchaser  Indemnitee  shall not enter  into any  settlement  of any such  claim
without the prior  consent of the Company,  such consent not to be  unreasonably
withheld or delayed.  In no event shall the Company be liable under this Article
IX, and the  Company's  obligation  to defend,  indemnify  and hold harmless the
Purchaser  Indemnitee  shall  not  apply  to:  (a) any  special,  incidental  or
consequential  damages resulting from or based upon any breach by the Company of
any representation,  warranty,  covenant or obligation of the Company hereunder,
(b) any Purchaser Indemnifiable Losses until the aggregate amount of such Losses
exceeds  $5,000,000,  and (c) any  Purchaser  Indemnifiable  Losses in excess of
$50,000,000.  The remedies set forth in this Article 9 are  cumulative and shall
not be construed to restrict or otherwise  affect any other remedies that may be
available  to a  Purchaser  Indemnitee  or a Party  under any  other  agreement,
pursuant to statutory or common law or equity.  Notwithstanding  anything to the
contrary in this Agreement,  any claim for indemnification under this Article IX
must be brought prior to the second  anniversary of the Closing Date, except for
claims relating to the representations and warranties in Sections 2.1(d), 2.1(k)
and 2.1 (m)  which  can be  brought  any  time  prior to the  expiration  of the
applicable statute of limitations.

         Section  9.3   Survival  of   Representations   and   Warranties.   The
representations  and warranties of the Company contained in this Agreement shall
expire for all purposes on the second  anniversary  of the Closing Date,  except
for the representations and warranties contained in Sections 2.1(d),  2.1(k) and
2.1(m) which shall expire for all purposes  upon  expiration  of the  applicable
statute of limitations.

                                    ARTICLE X

                           INTERPRETATION; DEFINITIONS

         Section 10.1 Interpretation.  As used in this Agreement, unless the 
context otherwise requires:

         (a)  any reference to the Company and its Subsidiaries means the 
Company and each of its Subsidiaries;

         (b)  words of any gender include all genders;

         (c) words using the  singular or plural  number also include the plural
or singular number,

                                       24

<PAGE>

         respectively; and

         (d) the terms "hereof" "herein", and "hereby" and derivative or similar
         words refer to this entire Agreement.

         Section 10.2 Definitions.  For purposes of this Agreement, the 
following terms shall have the following meanings:

         "13D Group" is defined in Section 4.1(e).

         "Affiliate"  shall have the  meaning  set forth in Rule 12b-2 under the
Exchange Act (as in effect ono the date of this Agreement).

         "Agreement" is defined in the recitals to this agreement.

         "Beneficially  Owned,"  "Beneficial  Ownership" or any like  expression
with respect to any  securities  means  having  "beneficial  ownership"  of such
securities  (as  determined  pursuant  to Rule 13d-3  under the  Exchange  Act),
including  pursuant to any agreement,  arrangement or understanding,  whether or
not in writing.

         "Business Day" means any day on which banking institutions are open in
the City of Boston.

         "Closing" is defined in Section 1.2.

         "Closing Date" is defined in Section 1.2.

         "Code" means the Internal  Revenue  Code of 1986,  as amended,  and the
regulations promulgated thereunder, as amended.

         "Collaboration Agreement" is defined in the recitals to this Agreement.

         "Common Stock" is defined in the recitals to this Agreement.

         "Company" is defined in the recitals to this Agreement.

         "Company Intellectual Property" is defined in Section 2.1(p).

         "Company Stock Plans" is defined in Section 2.1(d).

         "Company SEC Documents" is defined in Section 2.1(f).

         "Contract" is defined in Section 2.1(c).


                                       25

<PAGE>

         "Discovery Program" shall have the meaning set forth in the 
Collaboration Agreement.

         "Employee"  means any employee or former employee of the Company or any
of its  Subsidiaries  or any  beneficiary  or dependent of any such  employee or
former employee.

         "Employee  Benefit  Plans"  means  all  defined  contribution,  defined
benefit,  welfare benefit,  bonus, incentive  compensation,  stock option, stock
purchase,   stock   appreciation   right,  stock  bonus,   incentive,   deferred
compensation,  insurance,  medical,  dental, vision, life, death benefit, fringe
benefit or other employee  benefit plans,  programs,  policies or  arrangements,
including without limitation,  any employment,  consulting,  offer,  secondment,
severance or other  termination  agreement,  whether or not an employee  benefit
plan within the meaning of section 3(3) of ERISA,  maintained  by the Company or
any of its Subsidiaries.

         "Environmental Laws" is defined in Section 2.1(m).

         "Environmental Permits" is defined in Section 2.1(m).

         "Equity   Security"   means  (i)  any  Common  Stock  or  other  Voting
Securities,  (ii) any securities of the Company convertible into or exchangeable
for Common Stock or other  Voting  Securities  or (iii) any  options,  rights or
warrants  (or any similar  securities)  issued by the Company to acquire  Common
Stock or other Voting Securities.

         "ERISA" means the Employee Retirement Income Security Act of 1974, as 
amended.

         "Exchange Act" means the  Securities  Exchange Act of 1934, as amended,
or any  successor  federal  statute  and the  rules and  regulations  of the SEC
promulgated thereunder, all as the same shall be in effect from time to time.

         "GAAP" means United States generally accepted accounting principles.

         "Governmental Entity" is defined in Section 2.1(c).

         "Hazardous Substances" is defined in Section 2.1(m).

         "HSR Act" is defined in Section 2.1(c).

         "Indemnifying Person" is defined in Section 9.2.

         "Intellectual  Property" means  trademarks,  trade names,  trade dress,
service  marks,   copyrights,   domain  names,  and  similar  rights  (including
registrations  and  applications to register or renew the registration of any of
the  foregoing),   patents  and  patent  applications,   trade  secrets,  ideas,
inventions,  improvements,  practices,  processes,  formulas, designs, know-how,
confidential business and technical  information,  computer software,  firmware,
data and documentation,

                                       26

<PAGE>

licenses of or agreements  relating to any of the  foregoing,  rights of privacy
and publicity,  moral rights, and any other similar intellectual property rights
and  tangible  embodiments  of any of the  foregoing  (in any  medium  including
electronic media.)

         "Intellectual   Property   License"   means   any   license,    permit,
authorization,  approval,  Contract  or consent  granted,  issued by or with any
Person relating to the use of Intellectual Property.

         "IRS" means the Internal Revenue Service.

         "Knowledge  of the  Company,"  "Knowledge  of the Company or any of its
Subsidiaries"  or any like  expression  means  to the  actual  knowledge  of the
persons listed on Schedule 10.2.

         "Lien" is defined in Section 2.1(c).

         "Losses" is defined in Section 9.1.

         "Material  Adverse Effect" on or with respect to an entity (or group of
entities  taken as a whole)  means any state of facts,  event,  change or effect
that has had, or would reasonably be expected to have, a material adverse effect
on (a) the business, properties, results of operations or financial condition of
such entity (or, if with respect  thereto,  of such group of entities taken as a
whole),  other than any state of facts,  event, change or effect attributable to
changes in general economic or market conditions affecting the biotechnology and
pharmaceutical  industries,  or (b) the  ability  of such  entity  (or  group of
entities) to consummate the  transactions  contemplated  under this Agreement or
the Registration Rights Agreement.

         "Material Contract" is defined in Section 2.1(j).

         "New Security"  means any Equity  Security  issued by the Company after
the Closing;  provided that "New Security"  shall not include (i) any securities
issuable upon conversion of any convertible Equity Security, (ii) any securities
issuable upon exercise of any option,  warrant or other similar Equity Security,
or (iii) any  securities  issuable in  connection  with any stock  split,  stock
dividend or  recapitalization of the Company where such securities are issued to
all stockholders of the Company on a pro rata basis.

         "Permit" is defined in Section 2.1(c).

         "Permitted Liens" means those Liens (A) securing debt that is reflected
on the  balance  sheets  or the  notes  thereto  contained  in the  Company  SEC
Documents  filed with the SEC and publicly  available  prior to the date hereof,
(B)  referred  to in  Schedule  2.1(j),  (c) for Taxes not yet due or payable or
being  contested  in good  faith  and for  which  adequate  reserves  have  been
established in accordance with GAAP, (D) that constitute mechanics',  carriers',
workmens' or like liens, liens arising under original purchase price conditional
sales contracts and equipment leases

                                       27

<PAGE>

with third parties  entered into in the ordinary  course,  (E) Liens incurred or
deposits made in the ordinary  course of business  consistent with past practice
in connection  with  workers'  compensation,  unemployment  insurance and social
security,  retirement  and  other  legislation  and  (F)  easements,  covenants,
declarations, rights or way, encumbrances, or similar restrictions in connection
with real property owned by the Company of any of its  Subsidiaries  that do not
materially  impair the use of such real  property  by the Company and any of its
Subsidiaries,  and in the case of Liens  described in clauses (B), (C), (D), (E)
or (F) that, individually or in the aggregate, would not have a material Adverse
Effect on the Company and its Subsidiaries, taken as a whole.

         "Person" means any individual, partnership, joint venture, corporation,
limited liability company,  trust,  unincorporated  organization,  government or
department or agency of a government or other entity.

         "Pharmaceutical    Alliances"    means   a    research,    development,
commercialization  and/or similar  agreement or arrangement  between the Company
and a  pharmaceutical,  biopharmaceutical,  biotechnology  or similar  entity in
which Equity Securities are sold to such entity or an Affiliate of such entity.

         "Plans" is defined in Section 2.1(l).

         "Pro Rata  Share"  means the  fraction  of an  entire  issuance  of New
Securities, the numerator of which shall be the number of shares of Common Stock
and other Voting  Securities  owned by Purchaser and its Affiliates  (other than
the Company and its Subsidiaries) on a fully-diluted  basis immediately prior to
such issuance of such New Securities  and the  denominator of which shall be the
aggregate  number  of  shares  of  Common  Stock  and  other  Voting  Securities
outstanding  on a  fully-diluted  basis (giving  effect to the conversion of all
then-outstanding options, warrants and other convertible securities) immediately
prior to such issuance of such New Securities.

         "Program Term" shall have the meaning set forth in the Collaboration
 Agreement.

         "Purchase Price" is defined in Section 1.1.

         "Purchaser" is defined in the recitals to this Agreement.

         "Purchaser Indemnifiable Losses" is defined in Section 9.1.

         "Purchaser Indemnitees" is defined in Section 9.1.


                                       28

<PAGE>

         "Registration Rights Agreement" is defined in the recitals to this 
Agreement.

         "Representative"  means an agent or  employee  of  Purchaser,  or of an
independent  public  accounting firm, law firm, or other  consulting  company or
advisor of Purchaser.

         "Research and Development  Funding  Transaction" means a transaction to
raise funding for the research and development of one or more specific products,
products in one or more disease areas and/or one or more specific  technologies,
in each  case  structured  as an "off  balance  sheet"  financing.  Examples  of
Research and Development Funding  Transactions are R&D partnerships,  SWORDs and
SPARCs.

         "SEC" means the Securities and Exchange Commission.

         "Securities  Act" means the Securities Act of 1933, as amended,  or any
successor federal statute,  and the rules and regulations of the SEC promulgated
thereunder, all as the same shall be in effect from time to time.

         "Shares" is defined in Section 1.1.

         "Subsidiary"  means,  as to any  Person,  any  corporation  at  least a
majority  of the shares of stock of which  having  general  voting  power  under
ordinary  circumstances  to elect a majority of the Board of  Directors  of such
corporation (irrespective of whether or not at the time stock of any other class
or classes  shall have or might have voting power by reason of the  happening of
any  contingency)  is, at the time as of which the  determination is being made,
owned by such Person,  or one or more of its  Subsidiaries or by such Person and
one or more of its Subsidiaries.

         "Subscription Notice" is defined in Section 3.1.

         "Taxes" is defined in Section 2.1(k).

         "Tax Returns" is defined in Section 2.1(k).

         "Total Voting Power" means at any time the total combined  voting power
in  the  general  election  of  directors  of all  the  Voting  Securities  then
outstanding.

         "Voting  Securities"  means at any time  shares of any class of capital
stock of the Company which are then  entitled to vote  generally in the election
of directors.


                                   ARTICLE XI

                                  MISCELLANEOUS


                                       29

<PAGE>


         Section  11.1  Severability.   If  any  term,  provision,  covenant  or
restriction of this Agreement is held by a court of competent jurisdiction to be
invalid,  void  or  unenforceable,  the  remainder  of  the  terms,  provisions,
covenants  and  restrictions  of this  Agreement  shall remain in full force and
effect and shall in no way be affected,  impaired or  invalidated.  It is hereby
stipulated  and declared to be the intention of the parties that they would have
executed the remaining terms,  provisions,  covenants,  and restrictions without
including  any of  such  which  may  be  hereafter  declared  invalid,  void  or
unenforceable.

         Section 11.2 Specific Enforcement.  Purchaser, on the one hand, and the
Company, on the other, acknowledge and agree that irreparable damage would occur
in the event that any of the  provisions of this Agreement were not performed in
accordance  with  their  specific  terms  or  were  otherwise  breached.  It  is
accordingly  agreed that the  parties  shall be  entitled  to an  injunction  or
injunctions  to prevent  breaches of the  provisions  hereof in any court of the
United States or any state thereof having  jurisdiction,  this being in addition
to any other remedy to which they may be entitled at law or equity.

         Section 11.3 Entire Agreement.  This Agreement (including the documents
set forth in the Exhibits and Schedules hereto) and the Collaboration  Agreement
contain the entire understanding of the parties with respect to the transactions
contemplated hereby.

         Section 11.4  Counterparts.  This  Agreement  may be executed in one or
more counterparts,  all of which shall be considered one and the same agreement,
and shall become effective when one or more of the counterparts have been signed
by each party and delivered to the other parties,  it being  understood that all
parties need not sign the same counterpart.

         Section 11.5 Notices. All notices and other communications  required or
permitted  under this Agreement  shall be effective upon receipt and shall be in
writing and may be delivered in person, by telecopy,  overnight delivery service
or registered or certified  United States mail,  addressed to the Company or the
Purchaser, as the case may be, at their respective addresses set forth below:

If to the Company:


                      MILLENNIUM PHARMACEUTICALS, INC.
                      238 Main Street
                      Cambridge, Massachusetts  02139-4815
                      Attn: Chief Executive Officer
                      Telephone (617) 679-7000
                      Facsimile: (617) 621-0264


With copies to:

                                       30

<PAGE>

                           Attention: Legal Department

and to

                      Hale and Dorr LLP
                      60 State Street
                      Boston, Massachusetts 01209
                      Attn: Steven Singer
                      Telephone (617) 526-6000
                      Facsimile: (617) 526-5000


If to Purchaser:

                      BAYER AG
                      D 51368
                      Leverkeusen
                      Federal Republic of Germany
                      Attn: General Counsel
                      Telephone: 011 49 214 30 81803
                      Facsimile:  011 49 214 30 50848

With copies to:

                      Bayer Corporation, Inc.
                      400 Morgan Lane
                      West Haven, CT
                      Attn: Legal Department
                      Telephone: (203) 812 - 2401
                      Facsimile:  (203) 812 - 2795


and to:

                      Wilmer, Cutler & Pickering
                      2445 M Street
                      Washington, D.C.  20037
                      Attn: Richard W. Cass
                      Telephone (202) 663-6503
                      Facsimile: (202) 663-6363


All notices and other communications shall be effective upon the earlier of
actual receipt thereof

                                       31

<PAGE>

by the  person to whom  notice is  directed  or (a) in the case of  notices  and
communications  sent by personal  delivery or  telecopy,  one business day after
such  notice  or  communication   arrives  at  the  applicable  address  or  was
successfully sent to the applicable  telecopy number, (b) in the case of notices
and communications  sent by overnight delivery service,  at noon (local time) on
the second  business day  following  the day such notice or  communications  was
delivered  to  such  delivery  service,  and  (c) in the  case  of  notices  and
communications  sent by United  States  mail,  seven days  after such  notice or
communication  shall have been  deposited in the United States mail.  Any notice
delivered to a party hereunder shall be sent simultaneously,  by the same means,
to such party's counsel as set forth above.

         Section 11.6 Amendments.  This Agreement may be amended as to Purchaser
and their  successors and assigns  (determined as provided in Section 11.8), and
the Company may take any action  herein  prohibited,  or omit to perform any act
required to be performed by it, if the Company shall obtain the written  consent
of Purchaser. This Agreement may not be waived, changed, modified, or discharged
orally,  but only by an  agreement  in  writing  signed by the party or  parties
against whom  enforcement of any waiver,  change,  modification  or discharge is
sought  or by  parties  with  the  right  to  consent  to such  waiver,  change,
modification or discharge on behalf of such party.

         Section 11.7  Cooperation.  Purchaser and the Company agree to take, or
cause to be taken,  all such  further or other  actions as shall  reasonably  be
necessary to make effective and consummate the transactions contemplated by this
Agreement,  including, without limitation, making all required filings under the
HSR Act, if any.

         Section 11.8  Successors  and Assigns.  All  covenants  and  agreements
contained  herein shall bind and inure to the benefit of the parties  hereto and
their respective successors and assigns;  provided,  however, that Purchaser may
assign its rights  hereunder  (including its right to purchase the Shares) to an
Affiliate of  Purchaser,  provided that such  Affiliate  agrees in writing to be
bound by the terms and  conditions  set forth  herein,  and the  Company may not
assign any of its rights  under this  Agreement  without the written  consent of
Purchaser, which consent shall not be unreasonably withheld.

         Section 11.9  Expenses and  Remedies.  Whether or not the Closing takes
place, all costs and expenses incurred in connection with this Agreement and the
transactions  contemplated  hereby  shall be borne by the party  incurring  such
expense.

         Section 11.10 Transfer of Shares. Purchaser understands and agrees that
the Shares have not been  registered  under the Securities Act or the securities
laws of any state and that they may be sold or otherwise disposed of only in one
or more transactions  registered under the Securities Act and, where applicable,
such laws or as to which an exemption from the registration  requirements of the
Securities  Act  and,  where  applicable,  such  laws  is  available.  Purchaser
acknowledges  that  except as  provided in the  Registration  Rights  Agreement,
Purchaser  has no right to  require  the  Company  to  register  the  Shares and
understands and agrees that each

                                       32

<PAGE>

certificate  representing  the Shares  (other  than,  with  respect to the first
legend,  Shares that are no longer  subject to the  provisions  of Article V and
other  than,  with  respect  to  the  second  legend,  Shares  which  have  been
transferred in a transaction  registered under the Securities Act or exempt from
the  registration  requirements  of the  Securities  Act  pursuant  to Rule  144
thereunder or any similar rule or regulation) shall bear the following legends:

                      "THE TRANSFER OF THE SECURITIES REPRESENTED BY THIS
                  CERTIFICATE IS RESTRICTED BY AN AGREEMENT ON FILE AT THE
                  OFFICE OF THE CORPORATION."

                      "THE SECURITIES  REPRESENTED BY THIS  CERTIFICATE HAVE NOT
                  BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF  1933  OR THE
                  SECURITIES  LAWS OF ANY STATE AND MAY NOT BE SOLD OR OTHERWISE
                  DISPOSED  OF  EXCEPT  PURSUANT  TO AN  EFFECTIVE  REGISTRATION
                  STATEMENT UNDER SUCH ACT AND APPLICABLE  STATE SECURITIES LAWS
                  OR AN APPLICABLE EXEMPTION TO THE REGISTRATION REQUIREMENTS OF
                  SUCH ACT OR SUCH LAWS."

and  Purchaser  agrees  to  transfer  the  Shares  only in  accordance  with the
provisions of such legends.

         Section 11.11  Governing Law. This  Agreement  shall be governed by and
construed  and  enforced  in  accordance  with the laws of the State of Delaware
without regard to conflicts of law principles.

         Section 11.12  Publicity.  The Company and  Purchaser  will consult and
cooperate with each other before issuing, and provide each other the opportunity
to review and comment  upon,  any press  release or otherwise  making any public
statement with respect to the transactions contemplated by this Agreement.

         Section 11.13 No Third Party  Beneficiaries.  Nothing contained in this
Agreement  is intended to confer upon any Person  other than the parties  hereto
and their respective  successors and permitted  assigns,  any benefit,  right or
remedies  under or by  reason of this  Agreement;  provided,  however,  that the
parties  hereto  hereby  acknowledge  and agree that the  Purchaser  Indemnities
(other  than  Purchaser)  are third  party  beneficiaries  of Article IX of this
Agreement.

         Section  11.14  Consent  to  Jurisdiction.  Each  of  the  Company  and
Purchaser  irrevocably  submits to the personal  exclusive  jurisdiction  of the
United  States  District  Court for the District of Delaware for the purposes of
any suit,  action  or other  proceeding  arising  out of this  Agreement  or any
transaction  contemplated  hereby (and, to the extent permitted under applicable
rules of  procedure,  agrees not to  commence  any  action,  suit or  proceeding
relating hereto except in such court). Each of the Company and Purchaser further
agrees that service of any process,  summons,  notice or document hand delivered
or sent by registered mail to such party's respective address

                                       33

<PAGE>

set forth in Section 11.5 will be  effective  service of process for any action,
suit or  proceeding  in  Delaware  with  respect to any  matters to which it has
submitted to jurisdiction as set forth in the  immediately  preceding  sentence.
Each of the Company and Purchaser  irrevocably  and  unconditionally  waives any
objection to the laying of venue of any action,  suit or proceeding  arising out
of this Agreement or the transactions  contemplated  hereby in the United States
District court for the District of Delaware,  and hereby further irrevocably and
unconditionally  waives  and agrees not to plead or claim in such court that any
such  action,  suit or  proceeding  brought in such court has been brought in an
inconvenient forum.


                                       34

<PAGE>

IN WITNESS  WHEREOF,  PURCHASER and the COMPANY have caused this Agreement to be
executed as of the day and year first above written.



                                      BAYER AG

                                      By:  /s/

                                      Authorized Signature


                                      By: /s/

                                      Authorized Signature




                                      MILLENNIUM PHARMACEUTICALS, INC.

                                      By:  /s/ 

                                      Title: 







                                       35
<PAGE>

Exhibit C

                        MILLENNIUM PHARMACEUTICALS, INC.

                          REGISTRATION RIGHTS AGREEMENT

         This REGISTRATION  RIGHTS AGREEMENT (this  "Agreement") is entered into
as of  November  10,  1998 by and  among  Millennium  Pharmaceuticals,  Inc.,  a
Delaware  corporation  (the  "Company"),  and Bayer AG, a  Federal  Republic  of
Germany corporation ("Purchaser").

                                    RECITALS

         WHEREAS,  the Company and the Purchaser have entered into an Investment
Agreement, dated as of September 22, 1998 (the "Investment Agreement"), pursuant
to which the Purchaser has agreed to purchase 4,957,660 shares (the "Shares") of
common  stock,  par value $.001 per share,  of the  Company,  upon the terms and
conditions set forth therein;

         WHEREAS,  in order to induce the Purchaser to enter into the Investment
Agreement,  the Company has agreed to provide the registration  rights set forth
in this  Agreement  for the  benefit of  Purchaser  and its direct and  indirect
transferees upon the terms and conditions set forth herein; and

         WHEREAS, the execution and delivery of this Agreement is a condition to
the Purchaser's obligations pursuant to the Investment Agreement.

         NOW, THEREFORE, in consideration of the mutual premises,  covenants and
conditions set forth herein, the parties hereby agree as follows:

         1. Definitions.  Capitalized terms used herein without definition shall
have the meanings  assigned to such terms in the Investment  Agreement.  For the
purposes of this Agreement:

         "Commission" means the U.S.  Securities and Exchange  Commission or any
other governmental authority from time to time administering the Securities Act.

         "Common Stock" means the common stock, par value $.001 per share, of 
the Company.

         "DTC" means the Depository Trust Company.

         "Exchange Act" means the  Securities  Exchange Act of 1934, as amended,
or any  successor  federal  statute  and the  rules and the  regulations  of the
Commission promulgated thereunder,  all as the same shall be in effect from time
to time.


                                      - 1 -

<PAGE>

         "Holder"  means  any  Person  owning or  having  the  right to  acquire
Registrable  Securities,  including an Affiliate or any  successor,  assignee or
transferee of Purchaser or a Holder that has received Registrable  Securities in
accordance with Section 13 hereof.

         "NASD" means the National Association of Securities Dealers, Inc.

         "Person"  means any natural  person,  firm,  partnership,  association,
corporation, company, joint venture, unincorporated association, trust, business
trust,  government or department  or agency of a government,  limited  liability
company or other entity.

         "Prospectus"   means  the  prospectus   included  in  any  Registration
Statement (including without limitation, a prospectus that discloses information
previously omitted from a prospectus filed as part of an effective  registration
statement  in  reliance  upon Rule  430A),  as  amended or  supplemented  by any
prospectus supplement,  with respect to the terms of the offering or any portion
of the Registrable  Securities  covered by such  Registration  Statement and all
other  amendments and  supplements to the prospectus,  including  post-effective
amendments,  and  all  material  incorporated  by  reference  or  deemed  to  be
incorporated by reference in such prospectus.

         "Registrable  Securities" means (a) the Shares of Common Stock received
by the Purchaser pursuant to the Investment  Agreement and (b) any capital stock
or other  securities  of the  Company  issued or  issuable  with  respect to the
Shares,  (i) upon  any  conversion  or  exchange  thereof,  (ii) by way of stock
dividend or other distribution,  stock split or reverse stock split, or (iii) in
connection   with   a   combination   of   shares,   recapitalization,   merger,
consolidation,  exchange  offer or other  reorganization.  As to any  particular
Registrable   Securities,   once  issued  such  securities  shall  cease  to  be
Registrable  Securities  when (A) a  Registration  Statement with respect to the
sale of such securities shall have become effective under the Securities Act and
such securities shall have been disposed of in accordance with such Registration
Statement,  (B) such  securities  shall have been  distributed  to the public in
reliance upon Rule 144 (or any successor  provision)  under the Securities  Act,
provided that at the time such  securities  are proposed to be disposed of, they
may be sold  under  Rule  144  without  any  limitation  on the  amount  of such
securities which may be sold or (C) they shall have ceased to be outstanding.

         "Registration  Expenses"  means all fees and  expenses  incident to the
performance of or compliance with the provisions of this  Agreement,  whether or
not any Registration Statement is filed or becomes effective, including, without
limitation, all (a) registration and filing fees (including, without limitation,
(i)  fees  with  respect  to  filings  required  to be made and  other  expenses
associated with the NASD and any other applicable exchange in connection with an
underwritten  offering,  and (ii) fees and  expenses  of  compliance  with state
securities  or  blue  sky  laws  (including,   without   limitation,   fees  and
distributions  of counsel for the underwriter or underwriters in connection with
blue sky  qualifications  of the  Registrable  Securities and  determination  of
eligibility of the Registrable  Securities for investment under the laws of such
jurisdictions  as  are  provided  in  Section  5(e)),   (b)  printing   expenses
(including,   without   limitation,   expenses  of  printing   certificates  for
Registrable  Securities  in a form eligible for deposit with DTC and of printing
prospectuses), (c) fees

                                      - 2 -

<PAGE>

and disbursements of all independent certified public accountants referred to in
Section 5 (including, without limitation, the reasonable expenses of any special
audit and "cold comfort" letters  required by or incident to such  performance),
(d) the fees and expenses of any "qualified  independent  underwriter"  or other
independent appraiser participating in an offering pursuant to the NASD Rules of
Conduct  and the  corresponding  rules of any  other  applicable  exchange,  (e)
liability  insurance under the Securities Act or any other  securities  laws, if
the Company  desires such  insurance,  (f) fees and  expenses of all  attorneys,
advisers, appraisers and other persons retained by the Company or any Subsidiary
of the  Company,  (g)  internal  expenses of the  Company  and its  Subsidiaries
(including,  without  limitation,  all  salaries  and  expenses of officers  and
employees of the Company and its  Subsidiaries,  other general overhead expenses
of the Company and its  Subsidiaries,  and other expenses for the performance of
legal or  accounting  duties),  (h) the  expense  of any  annual  audit  and the
preparation  of  historical  and pro forma  financial  statements  or other data
normally  prepared by the Company in the ordinary  course of  business,  (i) the
expenses relating to printing, word processing and distributing all Registration
Statements,  underwriting agreements, securities sales agreements, and any other
documents  necessary  in order to comply with this  Agreement,  (j) any fees and
disbursements of any other underwriters and  broker-dealers  customarily paid by
issuers or sellers of securities, and (k) the fees and disbursements of not more
than one (1) counsel  (together with  appropriate  local counsel)  chosen by the
Holders of a majority  of the  Registrable  Securities  to be  included  in such
Registration  Statement;  provided,  however,  that in all  cases in  which  the
Company  is  required  to  pay  Registration  Expenses  hereunder,  Registration
Expenses shall exclude any underwriting  discounts,  selling  commissions or any
transfer taxes payable in respect of the sale of the  Registrable  Securities by
the Holders thereof.

         "Registration  Statement"  means  any  registration  statement  of  the
Company that covers any of the Registrable Securities pursuant to the provisions
of this Agreement,  and all amendments and supplements to any such  registration
statement,  including  post-effective  amendments,  in each case  including  the
Prospectus, all exhibits and all material incorporated by reference or deemed to
be incorporated by reference in such registration statement.

         "Rule  144"  means  Rule 144 (or any  successor  provision)  under  the
Securities Act.

         "Securities  Act" means the Securities Act of 1933, as amended,  or any
successor  federal  statute,  and the rules and  regulations  of the  Commission
promulgated thereunder, all as the same shall be in effect from time to time.

         "Special  Registration"  means  the  registration  of share  of  equity
securities  and/or  options  or other  rights in  respect  thereof to be offered
solely to directors,  members of  management,  employees,  consultants  or sales
agents,  distributors or similar representatives of the Company or its direct or
indirect Subsidiaries,  solely on Form S-8 or any successor form, a registration
on Form S-4 with  respect to any  merger,  consolidation  or  acquisition,  or a
registration  on  another  form  not  available  for   registering   Registrable
Securities for sale to the public.


                                      - 3 -

<PAGE>

         "underwritten   registration"  or   "underwritten   offering"  means  a
registration  in  which  securities  of  the  Company   (including   Registrable
Securities) are sold to an underwriter for reoffering to the public.

         2.       Demand Registration.

                  (a) Request for  Registration.  Subject to the  provisions  of
Sections  2(d)  and 8, at any time or from  time to time as of the date  hereof,
Holders of Registrable Securities shall have the right to make a written request
that the Company effect a  registration  under the Securities Act of all or part
of its Registrable  Securities of the Holders making such request. A request for
registration pursuant to this Section 2 (a "Demand  Registration") shall specify
the approximate number of Registrable Securities requested to be registered, the
anticipated  per share price range for such offering and the intended  method or
disposition thereof by such Holders.

                  (b)  Obligation to Effect  Registration.  Within five (5) days
after receipt by the Company of any request for Demand Registration, the Company
shall  promptly  give  written  notice  of such  requested  registration  to all
Holders.  Such Holders  shall have the right,  by giving  written  notice to the
Company within twenty (20) days after the Company provides its notice,  to elect
to have included in such registration  such of their  Registrable  Securities as
such  Holders  may request in such notice of  election.  Thereupon,  the Company
shall, as expeditiously  as possible,  use reasonable best efforts to effect the
registration  under the Securities Act of all  Registrable  Securities  that the
Company has been requested to so register; provided, that if the underwriter (if
any) managing the offering determines that, because of marketing factors, all of
the Registrable  Securities requested to be registered by all Holders may not be
included in the offering, then all Holders who have requested registration shall
participate  in the  offering  pro rata  based  upon the  number of  Registrable
Securities that they have requested to be so registered.

                  (c)  Registration  Statement  Form.  Registrations  under this
Section 2 shall be on such  appropriate  form of  Registration  Statement of the
Commission  as shall be selected by the  Company and  available  to it under the
Securities Act. The Company agrees to include in any such Registration Statement
all information which, in the opinion of counsel to the Company,  is required to
be included therein under the Securities Act.

                  (d)  Limitations  on  Registration.  The Company  shall not be
required  to effect  more than two (2)  Demand  Registrations  pursuant  to this
Section  2. In  addition,  the  Company  shall not be  required  to  effect  any
registration (other than on Form S-3 or any successor form relating to secondary
offerings) during the period starting with the date sixty (60) days prior to the
Company's  estimated  date of filing of, and ending on the date ninety (90) days
immediately  following the effective date of, any registration  statement (other
than a  Special  Registration)  pertaining  to the  securities  of the  Company,
provided  that the Company is actively  employing  in good faith all  reasonable
efforts   to  cause   such   registration   statement   to   become   effective.
Notwithstanding any other provision of this Agreement,  the Company shall not be
required to effect the Demand

                                      - 4 -

<PAGE>

Registration of any Registrable  Securities  prior to the second  anniversary of
the closing date of the Investment Agreement.

                  (e)  Inclusion  of Other  Securities.  The  Company  shall not
register securities (other than Registrable Securities) for sale for the account
of any Person in any request for Demand Registration,  unless permitted to do so
by the written  consent of the Holders of at least a majority of the Registrable
Securities proposed to be sold in such Demand Registration.

                  (f) Effective  Registration  Statement.  A Demand Registration
shall  not be  deemed  to have been  effected  unless a  Registration  Statement
covering  all of the  Registrable  Securities  requested  to be included in such
registration by the Holders thereof and as reduced, if necessary,  in accordance
with  Section 2(g) hereto has been  declared  effective  by the  Commission  and
remains continually effective for the period specified in Section 5(b).

                  (g) Suspension.  If the Board of Directors of the Company,  in
its good faith judgment,  determines that any registration  under the Securities
Act of Registrable  Securities  should not be made or continued because it would
materially  interfere  with any  material  financing,  acquisition,  corporation
reorganization, merger, or other transaction involving the Company or any of its
subsidiaries (a "Valid Business Reason"),  (i) the Company may postpone filing a
Registration  Statement  relating  to a Demand  Registration  until  such  Valid
Business  Reason no longer  exists,  but in no event for more than 60 days,  and
(ii) in case a  Registration  Statement  has  been  filed  relating  to a Demand
Registration,  the Company may cause such Registration Statement to be withdrawn
and its effectiveness  terminated or may postpone amending or supplementing such
Registration Statement until such Valid Business Reason no longer exists, but in
no event for more than 60 days (the "Postponement Period");  provided,  however,
that in no event  shall the  Company be  permitted  to  postpone  or  withdraw a
Registration  Statement within 120 days after the expiration of any Postponement
Period.

                  (h)  Allocation.   If  any  Demand  Registration  involves  an
underwritten offering and the managing underwriter of such offering shall advise
the Company that, in its view, the number of securities requested to be included
in such registration exceeds the largest number (the "Section 2(h) Number") that
can be  sold in an  orderly  manner  in  such  offering  within  a  price  range
acceptable to the Holders of Registrable Securities requesting the registration,
the Company shall include in such registration:

                           (i)      first, all Registrable Securities requested
to be included in such Registration by the Holders of Registrable   Securities 
requesting such registration; provided, however, that, if the number  of  such
Registrable Securities  exceeds  the Section  2(h)  Number,  the number of such 
Registrable Securities (not to exceed the Section 2(h) Number) shall be 
allocated to the Holders of Registrable Securities requesting such registration;
provided further, however, that if the number of Registrable  Securities 
requested to be included by all Holders of Registrable  Securities  requesting 
such registration exceeds the Section 2(h) Number, then the number of such 
Registrable  Securities included in such registration shall be allocated on a 
pro rata basis among all

                                      - 5 -

<PAGE>

Holders of Registrable  Securities  requesting such  registration,  based on the
number of Registrable  Securities that each such Holder requesting  registration
then owned by all such Holders requesting such registration; and

                           (ii)  second,  to the extent  that  consent  has been
granted in accordance with
Section  2(e) and the number of  Registrable  Securities  to be  included by all
Holders of Registrable  Securities requesting such registration is less than the
Section 2(h) Number, securities that the Company proposes to register.

         3.       Piggyback Registration.

                  (a) Inclusion in Piggyback Registration. If the Company at any
time proposes to register any of its securities  under the Securities Act (other
than pursuant to Section 2 or a Special  Registration),  whether or not for sale
for its own account, (a "Company Registration"),  it shall each such time, prior
to such  filing,  give  prompt  written  notice to all  Holders  of  Registrable
Securities of its intention to do so and, upon the written request of any Holder
of Registrable Securities given to the Company within twenty (20) days after the
Company has provided such notice (which request shall state the intended  method
of disposition of such Registrable Securities), the Company shall use reasonable
best  efforts to cause all  Registrable  Securities  that the  Company  has been
requested  by the  Holders  thereof to register  to be so  registered  under the
Securities Act to the extent necessary to permit their disposition in accordance
with the  intended  methods of  distribution  specified  in the  request of such
Holder or Holders;  provided, that if at any time after giving written notice of
its intention to register any  securities and prior to the effective date of the
Registration  Statement filed in connection with such registration,  the Company
shall determine for any reason not to register such securities, the Company may,
at its election,  give written notice of such  determination to each Holder that
was previously notified of such registration, and, thereupon, shall not register
any  Registrable  Securities in  connection  with such  registration  (but shall
nevertheless pay the  Registration  Expenses in connection  therewith),  without
prejudice,  however, to the rights of any Holders to request that a registration
be effect under Section 2 and provided  further,  that no registration  effected
under this Section 3 shall  relieve the Company from its  obligations  to effect
Registration upon request under Section 2.

                  (b) Terms of  Underwriting.  In  connection  with any offering
under this Section 3 involving an underwritten  offering,  the Company shall not
be required to include any  Registrable  Securities in such offering  unless the
Holder thereof  accepts the terms,  if any, of the  underwriting  as agreed upon
between the Company and the underwriters selected by it provided that such terms
must  be  reasonably  satisfactory  in  substance  and  form to the  Holder  and
consistent with this  Agreement,  and then only in such quantity as will not, in
the opinion of the managing underwriter,  jeopardize the success of the offering
by the Company.

                  (c)  Allocation.  If  any  Company  Registration  involves  an
underwritten offering and the managing underwriter of such offering shall advise
the Company that, in its view, the number of securities requested to be included
in such registration exceeds the largest number (the

                                      - 6 -

<PAGE>

"Section 3(c)  Number")  that can be sold in an orderly  manner in such offering
within a price range  acceptable  to the Company,  the Company  shall include in
such registration:

                           (i)      first, all securities that the Company 
proposes to register for its own account (the "Company Securities"); and

                          (ii)      second, to the extent that the number of 
Company Securities is less than the Section 3(c) Number,  the  remaining  
securities to be included in such registration shall be allocated on a pro rate
basis among (i) all Holders of Registrable  Securities  requesting that 
Registrable Securities be included in such Registration, and (ii) all other 
holders ("Other Holders") of the Company's securities who have been granted 
"piggy-back"  registration rights with respect to such securities (the "Other 
Securities")  and have requested that such Other Securities be included in such
registration,  based on the number of Registrable Securities  and  Other  
Securities that each such Holder and Other Holder requesting such registration
bears to the aggregate number of Registrable Securities and Other Securities 
then owned by all such Holders and Other Holders requesting such registration.

         4.  Allocation  of  Expenses.  The  Company  will pay all  Registration
Expenses of all registrations under this Agreement.

         5. Obligations of the Company.  If and whenever the Company is required
to use best efforts to effect the  registration  under the Securities Act of any
Registrable  Securities  pursuant  to  Section  2 and 3 of this  Agreement,  the
Company shall:

                  (a)  file  with  the  Commission,  as soon as  practicable,  a
Registration  Statement with respect to such  Registrable  Securities,  make all
required filings with the NASD and any other applicable  exchange,  and use best
efforts to cause such Registration Statement to become effective at the earliest
possible date and remain effective;

                  (b) prepare and file with the Commission  such  amendments and
supplements to the Registration  Statement and the Prospectus used in connection
therewith and such other documents as may be necessary to keep the  Registration
Statement  effective  until the earlier of (i) 210 days after the effective date
of such  Registration  Statement or (ii) the  consummation of the disposition by
the  Holders of all the  Registrable  Securities  covered  by such  Registration
Statement and otherwise  comply with the  provisions of the  Securities Act with
respect  to the  disposition  of all  securities  covered  by such  Registration
Statement;

                  (c) furnish to counsel  (if any)  selected by the Holders of a
majority of the Registrable  Securities  covered by such Registration  Statement
and to counsel for the underwriters in any  underwritten  offering copies of all
documents  proposed  to be filed with the  Commission  in  connection  with such
registration  a reasonable  time prior to the proposed  filing  thereof and give
reasonable  consideration in good faith to any comments of such Holders, counsel
and underwriters.

                                      - 7 -

<PAGE>

                  (d) furnish to each seller of such securities, without charge,
such number of conformed copies of such Registration  Statement and of each such
amendment  and  supplement  thereto  (in  each  case,   including  all  exhibits
(including  all  exhibits  incorporated  by  reference),  financial  statements,
schedules,  and all documents  incorporated  therein,  deemed to be incorporated
therein by reference or filed  therewith,  except that the Company  shall not be
obligated to furnish any seller of securities  with more than two copies of such
exhibits and  documents),  such numbers of copies of the Prospectus  included in
such  Registration   Statement   (including  each  preliminary   prospectus)  in
conformity  with  the  requirements  of  the  Securities  Act,  and  such  other
documents,  as such seller may  reasonably  request in order to  facilitate  the
disposition of the Registrable Securities owned by such seller;

                  (e) use its reasonable best efforts to register or qualify and
cooperate with the Holders of Registrable Securities, the underwriters and their
respective  counsels in connection with the  registration or  qualification  (or
exemption from such registration or qualification) of the securities  covered by
such Registration Statement under such other securities or blue sky laws of such
jurisdictions  as each  seller  shall  request;  provided,  however,  that where
Registrable  Securities are offered other than through an underwritten offering,
the Company agrees to cause its counsel to perform blue sky  investigations  and
file  registrations  and  qualification  required  to be filed  pursuant to this
Section  5(e);  keep each  such  registration  or  qualification  (or  exemption
therefrom)  effective during the period such Registration  Statement is required
to be effective  hereunder and do any and all other acts and things which may be
necessary or advisable to enable such seller to consummate  the  disposition  in
such  jurisdictions  of the  securities  owned by such  seller,  except that the
Company  shall not for any such  purpose be required to qualify  generally to do
business  as a foreign  corporation  in any  jurisdiction  wherein  it is not so
qualified,  subject itself to taxation in any jurisdiction  wherein it is not so
subject, or take any action which would subject it to general service of process
in any jurisdiction wherein it is not so subject;

                  (f) in connection with an  underwritten  public offering only,
furnish to each seller in a signed counterpart, addressed to the sellers, of

                           (i)      an opinion of counsel for the Company
                  experienced in securities law matters, dated the effective 
                  date of the Registration Statement, and

                           (ii)  a  "cold   comfort"   letter   signed   by  the
                  independent public accountants who have issued an audit report
                  on  the  Company's   financial   statements  included  in  the
                  Registration Statement, subject to such seller having executed
                  and  delivered  to the  independent  public  accountants  such
                  certificates   and   documents  as  such   accountants   shall
                  reasonably request,

covering  substantially  the  same  matters  with  respect  to the  Registration
Statement  (and  the  Prospectus  included  therein)  and,  in the  case of such
accountants'  letter,  with  respect  to events  subsequent  to the date of such
financial statements, as are customarily covered in opinions of issuer's

                                      - 8 -

<PAGE>

counsel and in accountants' letters delivered to the underwriters in 
underwritten public offerings of securities;

                  (g) (i) notify each Holder of Registrable  Securities  subject
to such Registration Statement if such Registration Statement, at the time it or
any amendment thereto became  effective,  (x) contained an untrue statement of a
material fact or omitted to state a material fact required to be stated  therein
or necessary to make the statements therein not misleading upon discovery by the
Company of such material  misstatement  or omission or (y) upon discovery by the
Company of the happening of any event as a result of which the Company  believes
there would be such a material  misstatement  or  omission,  and, as promptly as
practicable,  prepare and file with the Commission a post-effective amendment to
such  Registration  Statement  and use  reasonable  best  efforts  to cause such
post-effective  amendment  to  become  effective  such  that  such  Registration
Statement,  as so amended,  shall not contain an untrue  statement or a material
fact or omit to state a material fact required to be stated therein or necessary
to make the statements  therein not  misleading,  and (ii) notify each Holder of
Registrable Securities subject to such Registration  Statement, at any time when
a Prospectus  related  therefor is required to be delivered under the Securities
Act, if the  Prospectus  included  in such  Registration  Statement,  as then in
effect,  includes  an untrue  statement  of a material  fact or omits to state a
material fact required to be stated  therein or necessary to make the statements
therein,  in  light  of the  circumstances  under  which  they  were  made,  not
misleading  upon  discovery  by the  Company of such  material  misstatement  or
omission or upon the discovery by the Company of the happening of any event as a
result of which the Company believes that there would be a material misstatement
or  omission,  and, as promptly as is  practicable,  prepare and furnish to such
Holder a reasonable  number of copies of a supplement to or an amendment of such
Prospectus  as  may  be  necessary  so  that,  as  thereafter  delivered  to the
purchasers  of such  securities,  such  Prospectus  shall not  include an untrue
statement  of a material  fact or omit to state a material  fact  required to be
stated  therein or necessary  to make the  statements  therein,  in light of the
circumstances under which they were made, not misleading;

                  (h) otherwise use its  reasonable  best efforts to comply with
all applicable  rules and regulations of the  Commission,  and make available to
its security holders, as soon as reasonably  practicable,  an earnings statement
of the Company  complying with the provisions of Section 11(a) of the Securities
Act and Rule 158 under the Securities Act (or any similar rule promulgated under
the Securities  Act) no later than 45 days after the end of any 12-month  period
(or 90 days  after the end of any  12-month  period  if such  period is a fiscal
year) (i)  commencing  at the end of any  fiscal  quarter  in which  Registrable
Securities are sold to an underwriter or to underwriters in a firm commitment or
best efforts underwritten offering, and (ii) if not sold to an underwriter or to
underwriters  in such an  offering,  commencing  on the  first  day of the first
fiscal  quarter  of the  Company  after  the  effective  date  of  the  relevant
Registration Statement, which statements shall cover said 12-month periods;

                  (i)  promptly  notify  each Holder of  Registrable  Securities
covered by such Registration  Statement,  their counsel and the underwriters (i)
when  such  Registration  Statement,  or any  post-effective  amendment  to such
Registration Statement, shall have become effective, or any


                                      - 9 -
<PAGE>

amendment of or supplement to the Prospectus used in connection  therewith shall
be filed,  (ii) of any  request by the  Commission  to amend  such  Registration
Statement  or  to  amend  or  supplement   such  Prospectus  or  for  additional
information,  (iii)  of  the  issuance  by the  Commission  of  any  stop  order
suspending  the  effectiveness  of such  Registration  Statement or of any order
preventing or suspending the use of any preliminary prospectus or the initiation
or  threatening  of any  proceedings  for  any of  such  purposes,  (iv)  of the
suspension of the  qualification  of such securities for offering or sale in any
jurisdiction,  or of the institution of any proceedings for any of such purposes
and (v) if at any time when a Prospectus is to be required by the Securities Act
to be delivered in connection with the sale of the Registrable  Securities,  the
representations  and  warranties  of the  Company  contained  in  any  agreement
(including the underwriting  agreement  contemplated in Section 6(b) below),  to
the  knowledge  of the  Company,  cease to be true and  correct in any  material
respect;

                  (j) use its reasonable best efforts to prevent the issuance of
any order suspending the  effectiveness of the Registration  Statement or of any
order  preventing  or  suspending  the use of a  Prospectus  or  suspending  the
qualification  (or  exemption  from  qualification)  of any  of the  Registrable
Securities covered thereby for sale in any jurisdiction,  and, if any such order
is issued,  to obtain the withdrawal of any such order at the earliest  possible
moment;

                  (k) if  requested  by the  managing  underwriter,  if any, (i)
promptly incorporate in a prospectus supplement or post-effective amendment such
information  as the  managing  underwriter,  if any,  reasonably  requests to be
included  therein to comply  with  applicable  law,  and (ii) make all  required
filings of such prospectus  supplement or such post-effective  amendment as soon
as practicable after the Company has received  notification of the matters to be
incorporated in such prospectus supplement or post-effective amendment;

                  (l) cooperate  with the Holders and the managing  underwriter,
if any, to  facilitate  the timely  preparation  and  delivery  of  certificates
representing  Registrable  Securities to be sold, which  certificates  shall not
bear any  restrictive  legends  whatsoever  and shall be in a form  eligible for
deposit  with  DTC,  and  enable  such  Registrable  Securities  to be  in  such
denominations  and  registered  in such names as the  underwriters,  if any,  or
Holders may reasonably  request at least two (2) business days prior to any sale
of Registrable Securities in a firm commitment underwritten public offering;

                  (m) use its reasonable  best efforts to cause the  Registrable
Securities  covered by a  Registration  Statement to be registered  with, and to
obtain the  consent or  approval  of,  each  governmental  agency or  authority,
whether federal,  state, local or foreign,  which may be required to effect such
registration  or the offering or sale in  connection  therewith or to enable the
sellers  to  offer,  or  to  consummate  the  disposition  of,  the  Registrable
Securities  subject to such  Registration  Statement,  except as may be required
solely as a consequence of the nature of such seller's  business,  in which case
the Company will cooperate  with all reasonable  respects with the filing of the
Registration Statement and the granting of such approvals;


                                     - 10 -

<PAGE>

                  (n) prior to the effective date of the Registration Statement,
(i)  provide  the  registrar  for the  Common  Stock or such  other  Registrable
Securities with printed  certificates for such securities in a form eligible for
deposit with DTC and (ii) provide a CUSIP number for such securities.

                  (o) The Company  agrees not to file or make any  amendment  to
any Registration  Statement with respect to any Registrable  Securities,  or any
amendment of or supplement to the Prospectus used in connection therewith, which
refers to any seller of any  securities  covered  thereby by name,  or otherwise
identifies  such seller as the holder of any securities of the Company,  without
the consent of such seller, such consent not to be unreasonably withheld, except
that no such consent  shall be required for any  disclosure  that is required by
law.

         6.  Underwritten  Offerings.  The  provisions  of this Section 6 do not
establish  additional  registration  rights  but  instead  set forth  procedures
applicable,  in  addition  to those  set  forth in  Sections  2, 3 and 5, to any
registration that is an underwritten offering.

                  (a)      Underwritten Offerings Exclusive.  Whenever a request
for Demand Registration is for an underwritten offering, only securities that 
are to be distributed by the underwriters may be included in the Registration.

                  (b) Underwriting  Agreement.  If requested by the underwriters
for any  underwritten  offering  by  Holders  pursuant  to a request  for Demand
Registration,  the Company shall enter into an underwriting  agreement with such
underwriters for such offering,  such agreement to be reasonably satisfactory in
substance and form to the Holders of a majority of the Registrable Securities to
be covered by such  registration  and to the  underwriters  and to contain  such
representations  and  warranties  by  the  Company  and  such  other  terms  and
provisions as are customarily  contained in agreements of this type,  including,
but not  limited  to,  indemnities  to the effect and to the extent  provided in
Section 10, provisions for the delivery of officers'  certificates,  opinions of
counsel and accountants' "cold comfort" letters, and hold-back arrangements. The
Holders of Registrable  Securities to be distributed by such underwriters  shall
be parties to such underwriting agreement and may, at their option, require that
any or all the representations and warranties by, and the agreements on the part
of, the Company to and for the benefit of such  underwriters  be made to and for
the benefit of such Holders and that any or all of the  conditions  precedent to
the obligations of such underwriters  under such  underwriting  agreements shall
also be conditions precedent to the obligations of such Holders. No such Holders
shall be required by the Company to make any  representations  or warranties to,
or agreements with, the Company or the  underwriters  other than as set forth in
Section 6(d) and representations, warranties or agreements regarding such Holder
and such Holders's intended method of distribution.

                  (c) Selection of  Underwriters.  Whenever a request for Demand
Registration is for an underwritten  offering,  the Holders of a majority of the
Registrable Securities to be Registered pursuant to such offering shall have the
right to select one or more underwriters to administer the offering,  subject to
the consent of the Company, which shall not be unreasonably withheld. If the

                                     - 11 -

<PAGE>

Company  at any time  proposes  to  register  any of its  securities  under  the
Securities  Act for  sale for its own  account  and  such  securities  are to be
distributed by or through one or more  underwriters,  the Company shall have the
right to select one or more underwriters to administer the offering,  subject to
the  consent of the Holders of a majority of the  Registrable  Securities  to be
registered pursuant to such offering,  which shall not be unreasonably withheld.
In all cases in this Section  6(c), at least one of the  underwriters  chosen by
the  Holders or the Company  shall be an  underwriter  of  nationally-recognized
standing.

                  (d) Hold Back Agreements. If and whenever the Company proposes
to register any of its equity  securities  under the Securities Act,  whether or
not for its own account (other than pursuant to a Special  Registration),  or is
required to use its best efforts to effect the  registration  of any Registrable
Securities under the Securities Act pursuant to Section 2 or 3, each Holder,  if
required by the managing  underwriter  in an  underwritten  offering,  agrees by
acquisition of such Registrable Securities not to effect (other than pursuant to
such  registration)  any  public  sale  or  distribution,   including,   without
limitation,  any sale pursuant to Rule 144, of any Registrable  Securities,  any
other equity  securities of the Company or any  securities  convertible  into or
exchangeable or exercisable for any equity  securities of the Company during the
ten (10) days prior to, and for ninety (90) days after,  the  effective  date of
such  registration,  to the extent timely  notified in writing by the Company or
the  managing  underwriter,  and the Company  agrees to cause each  director and
executive  officer of the  Company to enter  into a similar  agreement  with the
Company.  The foregoing  provisions shall not apply to any Holder if such Holder
is prevented by  applicable  statute or  regulation  from entering into any such
agreement,;  provided,  however,  that any such Holder shall  undertake,  in its
request to  participate  in any such  underwritten  offering,  not to effect any
public sale or  distribution of any applicable  class of Registrable  Securities
commencing  on the  date  of  sale  of  such  applicable  class  of  Registrable
Securities  unless it has provided  forty-five (45) days prior written notice of
such sale or  distribution  to the  underwriter  or  underwriters.  The  Company
further  agrees not to effect  (other  than  pursuant  to such  registration  or
pursuant to a Special Registration) any public sale or distribution,  or to file
any   Registration   Statement   (other  than  such   registration   or  Special
Registration)  covering  any,  of  its  equity  securities,  or  any  securities
convertible into or exchangeable or exercisable for such securities,  during the
ten (10) days prior to, and for ninety (90) days after,  the  effective  date of
such registration if required by the managing underwriter.


         7.  Preparation,  Reasonable  Investigation.  In  connection  with  the
preparation and filing of each Registration  Statement  registering  Registrable
Securities  under the  Securities  Act,  the  Company  shall give the Holders of
Registrable  Securities to be so registered and their underwriters,  if any, and
their respective counsel and accountants,  the opportunity to participate in the
preparation of such Registration Statement,  each Prospectus included therein or
filed with the Commission, and each amendment thereof or supplement thereto, and
shall give each of them such access to all pertinent financial,  corporate,  and
other  documents and  properties of the Company and its  Subsidiaries,  and such
opportunities  to  discuss  the  business  of the  Company  with  its  officers,
directors,  employees and the  independent  public  accountants  who have issued
audit reports on its

                                     - 12 -

<PAGE>

financial statements as shall be necessary,  in the opinion of such Holders' and
such underwriters'  respective  counsel,  to conduct a reasonable  investigation
within the meaning of the Securities Act.

         8. Other Registrations.  If and whenever the Company is required to use
its best  efforts to effect the  registration  under the  Securities  Act of any
Registrable  Securities  pursuant  to  Section 2 or 3, and if such  registration
shall not have been  withdrawn or abandoned,  the Company shall not be obligated
to and shall not file any  Registration  Statement  with  respect  to any of its
securities  (including  Registrable  Securities) under the Securities Act (other
than a Special  Registration),  whether of its own  accord or at the  request or
demand of any holder or holders of such  securities,  until a period of 180 days
shall  have  elapsed  from the  effective  date of such  previous  registration,
provided  that the  Company  shall not be  excused  from  filing a  Registration
Statement by virtue of this Section 8 more than once in a 360 day period.

         9.       Certain Obligations of Holders.

                  (a) The  Company may  require  each Holder of any  Registrable
Securities  as to which any  registration  is being  effected  to furnish to the
Company  such  information  regarding  such  Holder and the  intended  method of
disposition of such  securities as the Company may from time to time  reasonably
request in writing and as shall be required to effect the  registration  of such
Holder's Registrable Securities.  Each such Holder agrees to furnish promptly to
the  Company  all  information  required  to be  disclosed  in order to make the
information  previously  furnished to the Company by such Holder not  materially
misleading.

                  (b)  Each  Holder  of  Registrable  Securities  covered  by  a
Registration  Statement agrees that, upon receipt of any notice from the Company
pursuant to Section 5(g), such Holder will promptly  discontinue the disposition
of Registrable  Securities  pursuant to such  Registration  Statement until such
Holder shall have  received,  in the case of clause (i) of Section 5(g),  notice
from  the  Company  that  such  Registration  Statement  has  been  amended,  as
contemplated  by Section 5(g),  and, in the case of clause (ii) of Section 5(g),
copies of the supplemented or amended  Prospectus  contemplated by Section 5(g).
If so directed by the  Company,  each Holder will deliver to the Company (at the
Company's  expense)  all  copies,  other than  permanent  file  copies,  in such
Holder's  possession of the Prospectus  covering such Registrable  Securities at
the time of receipt of such notice. In the event that the Company shall give any
such  notice,  the period  mentioned  in Section  5(b) shall be  extended by the
number of days  during the period from and  including  the date of the giving of
such  notice  to and  including  the date when  each  seller of any  Registrable
Securities covered by such Registration  Statement shall have received copies of
the  supplemented or amended  Prospectus  covering such  Registrable  Securities
contemplated by Section 5(g).

         10.      Indemnification and Contribution.

                  (a) In the event of any registration of any of the Registrable
Securities under the Securities Act pursuant to this Agreement, the Company will
indemnify  and hold  harmless  the  seller of such  securities,  its  directors,
officers, and employees, each other Person who participates as an

                                     - 13 -

<PAGE>

underwriter,  broker or dealer in the offering or sale of such  securities,  and
each other person, if any, who controls such seller, underwriter, broker, dealer
or any such participating Person within the meaning of the Securities Act or the
Exchange Act,  against any losses,  claims,  damages,  or liabilities,  joint or
several,  to  which  such  seller  or  any  such  director,  officer,  employee,
underwriter,  broker,  dealer,  participating  Person, or controlling Person may
become subject under the Securities  Act, the Exchange Act, state  securities or
blue sky laws,  or  otherwise,  insofar  as such  losses,  claims,  damages,  or
liabilities  (or actions or proceedings in respect  thereof) arise out of or are
based upon any untrue statement or alleged untrue statement of any material fact
contained in any Registration  Statement under which such Registrable Securities
were  registered  under the  Securities  Act,  any  preliminary  prospectus,  or
Prospectus  contained  in  the  Registration  Statement,  or  any  amendment  or
supplement to such Registration Statement, or arise out of or are based upon the
omission  or alleged  omission  to state a material  fact  required to be stated
therein or  necessary to make the  statements  therein not  misleading;  and the
Company shall reimburse such seller and each such director,  officer,  employee,
underwriter,  broker,  dealer,  participating  Person, and controlling Person in
connection  with  investigating  or  defending  any such  loss,  claim,  damage,
liability,  action  or  proceeding  as such  expenses  are  incurred;  provided,
however, that the Company will not be liable in any such case to the extent that
any such loss,  claim,  damage,  liability or expense  arises out of or is based
upon any untrue  statement  or  omission  made in such  Registration  Statement,
preliminary prospectus,  or Prospectus,  or any such amendment or supplement, in
reliance upon and in conformity with  information  furnished to the Company,  in
writing, by or on behalf of such seller,  underwriter,  participating  Person or
controlling Person specifically for use in the preparation thereof.

                  (b) In the event of any registration of any of the Registrable
Securities  under the Securities Act pursuant to this Agreement,  each seller of
such securities, severally and not jointly, will indemnify and hold harmless the
Company,  each of its directors and officers and each  underwriter  (if any) and
each person, if any, who controls the Company or any such underwriter within the
meaning of the Securities Act or the Exchange Act,  against any losses,  claims,
damages, or liabilities,  joint or several, to which the Company, such directors
and officers,  underwriters, or controlling Persons may become subject under the
Securities Act,  Exchange Act, state  securities or blue sky laws, or otherwise,
insofar  as  such  losses,  claims,  damages,  or  liabilities  (or  actions  or
proceedings  in  respect  thereof)  arise  out of or are based  upon any  untrue
statement  or alleged  untrue  statement  of a material  fact  contained  in any
Registration  Statement under which such  securities  were registered  under the
Securities  Act,  any  preliminary  prospectus  or  Prospectus  contained in the
Registration  Statement,  or any  amendment or  supplement  to the  Registration
Statement, or arise out of or are based upon any omission or alleged omission to
state a material  fact  required to be stated  therein or  necessary to make the
statements  therein not  misleading,  if the  statement  or omission was made in
reliance  upon  and in  conformity  with  information  relating  to such  seller
furnished in writing to the Company by or on behalf of such seller expressly for
use  in  connection  with  the  preparation  of  such  Registration   Statement,
preliminary prospectus, Prospectus, amendment, or supplement; provided, however,
that the liability of each such seller  hereunder  shall be in proportion to and
limited  to the  net  amount  received  by  such  seller  (after  deducting  any
underwriting discount and expenses) from the sale of Registrable Securities sold
in connection with such registration.


                                     - 14 -

<PAGE>

                  (c) Each party entitled to indemnification  under this Section
10 (the "Indemnified  Party") shall give notice to the party required to provide
indemnification (the "Indemnifying Party") promptly after such Indemnified Party
has actual knowledge of any claim as to which indemnity may be sought, and shall
permit the  Indemnifying  Party to assume  the  defense of any such claim or any
litigation  resulting  therefrom;  provided,  that counsel for the  Indemnifying
Party,  who shall  conduct  the  defense of such claim or  litigation,  shall be
approved by the  Indemnified  Party (whose  approval  shall not be  unreasonably
withheld); and, provided,  further, that the failure of any Indemnified Party to
give notice as provided herein shall not relieve the  Indemnifying  Party of its
obligations  under this Section 10,  except to the extent that the  Indemnifying
Party  is  adversely  affected  by  such  failure.  The  Indemnified  Party  may
participate in such defense at such party's expense; provided, however, that the
Indemnifying  Party shall pay such expense if representation of such Indemnified
Party by the counsel retained by the  Indemnifying  Party would be inappropriate
due to  actual  or  potential  differing  interests  or  conflicts  between  the
Indemnified  Party and any  other  party  represented  by such  counsel  in such
proceeding.  No  Indemnifying  Party,  in the  defense  of  any  such  claim  or
litigation, shall, except with the consent of each Indemnified Party, consent to
entry of any judgment or enter into any  settlement  that does not include as an
unconditional  term  thereof  the giving by the  claimant or  plaintiff  to such
Indemnified  Party of a release  from all  liability in respect of such claim or
litigations,  and no Indemnified Party shall consent to entry of any judgment or
settle  such  claim or  litigation  without  the prior  written  consent  of the
Indemnifying Party, which consent shall not be unreasonably withheld.

                  (d) If for any reason the foregoing  indemnity is unavailable,
or is insufficient to hold harmless an Indemnified  Party,  other than by reason
of the  exceptions  provided in this  Section 10,  then the  Indemnifying  Party
shall, in lieu of indemnifying such Indemnified Party,  contribute to the amount
paid or payable by the  Indemnifying  Party as a result of such losses,  claims,
damages  liabilities or expenses in such proportion as is appropriate to reflect
the relative fault of the Indemnifying Party on the one hand and the Indemnified
Party on the other in connection with the statements or omissions which resulted
in such losses, claims,  damages, or liabilities,  as well as any other relevant
equitable  considerations.  The relative  fault shall be determined by reference
to,  among other  things,  whether the untrue or alleged  untrue  statement of a
material  fact or the  omission  or alleged  omission  to state a material  fact
relates to  information  supplied by the  Company or the Holders of  Registrable
Securities  covered by the  Registration  Statement in question and the parties'
relative intent, knowledge,  access to information and opportunity to correct or
prevent such statement or omission.

                  (e) The  Company  and the  Holders  agree that it would not be
just and equitable if  contribution  pursuant to this Section 10 were determined
by pro rata allocation or by any other method of allocation  which does not take
account of the equitable considerations referred to in Section 10(d). The amount
paid or  payable  by an  Indemnified  Party as a result of the  losses,  claims,
damages and liabilities referred to in Section 10(d) shall be deemed to include,
subject  to the  limitations  set  forth  above,  any  legal or  other  expenses
reasonably  incurred by such Indemnified Party in connection with  investigating
or  defending  any such claim or  litigation.  Notwithstanding  anything  to the
contrary in this  Section 10, (A) no such Holder will be required to  contribute
any

                                     - 15 -

<PAGE>

amount in excess of the  proceeds it received  from the sale of its  Registrable
Securities  pursuant to such  Registration  Statement,  (B) no Person  guilty of
fraudulent  misrepresentation,  within  the  meaning  of  Section  11(f)  of the
Securities  Act, shall be entitled to  contribution  from any Person who was not
guilty of such fraudulent misrepresentation and (C) no party shall be liable for
contribution  under  this  Section  10  except  to the  extent  and  under  such
circumstances  as such party  would  have been  liable to  indemnify  under this
Section 10 if such  indemnification  were enforceable  under applicable law. Any
party  entitled  to  contribution  will,  promptly  after  receipt  of notice of
commencement of any action,  suit or proceeding against such party in respect to
which a claim for  contribution  may be made  against  another  party or parties
under this Section,  notify such party or parties from whom  contribution may be
sought,  but  the  omission  so to  notify  such  party  or  parties  from  whom
contribution  may be  sought  shall  not  relieve  such  party  from  any  other
obligation it or they may have  thereunder or otherwise  under this Section.  No
party  shall be liable  for  contribution  with  respect  to any  action,  suit,
proceeding or claim settled  without its prior  written  consent,  which consent
shall not be unreasonably withheld.

         11. Indemnification with Respect to Underwritten Offering. In the event
that Registrable  Securities are sold pursuant to a Registration Statement in an
underwritten  offering,  the  Company  agrees  to  enter  into  an  underwriting
agreement  containing  customary  representations and warranties with respect to
the business and operations of an issuer of the securities  being registered and
customary  covenants and  agreements  to be performed by such issuer,  including
without limitation  customary  provisions with respect to indemnification by the
Company of the underwriters of such offering.

         12.  Reports  Under  Securities  Exchange  Act of 1934.  With a view to
making  available to the Holders the benefits of Rule 144 promulgated  under the
Securities  Act and any other rule or regulation of the  Commission  that may at
any time permit a Holder to sell  Registrable  Securities  of the Company to the
public without Registration, the Company agrees to:

                  (a) Make and keep public information available, as those terms
are understood and defined in Rule 144 under the Securities Act;

                  (b) file with the  Commission  in a timely  manner all reports
and other  documents  required of the Company under the  Securities  Act and the
Exchange Act; and

                  (c)  furnish to any  Holder,  so long as such  Holder owns any
Registrable  Securities,  forthwith upon request (i) a written  statement by the
Company that it has complied with the reporting  requirements  of Rule 144 under
the Securities Act, any other such applicable  reporting  requirements under the
Securities Act and all applicable reporting requirements under the Exchange Act,
(ii) a copy of the most  recent  annual or  quarterly  report of the Company and
such other reports and  documents so filed by the Company,  and (iii) such other
information as may be reasonably requested in availing any Holder of any rule or
regulation of the  Commission  which permits the selling of any such  securities
without Registration or pursuant to such form.


                                     - 16 -

<PAGE>

         13.  Successors,  Assigns  and  Transferees.  This  Agreement  shall be
binding  upon and shall  inure to the  benefit of each party  hereto,  and their
respective  successors,  assigns and  transferees.  The  Purchaser  or any other
Holder under this  Agreement  may assign its rights under this  Agreement to any
Affiliate or to other  successors,  assigns and  transferees of the Purchaser or
any such Holder;  provided,  however,  that the Company is given written  notice
from the Purchaser or any such Holder at the time of such  transfer  stating the
name and address of the transferee or assign and identifying the securities with
respect to which the rights hereunder are being  transferred.  As a condition to
the  effectiveness  of any transfer  permitted  hereunder (i) the  transferee or
assign shall agree, in writing,  upon request of the Company, to be bound by the
provisions of this Agreement, and (ii) the Company shall be given written notice
at the time of or within a reasonable  time after said  transfer or  assignment,
stating the name and address of said  transferee or assign and  identifying  the
securities  with respect to which such  registration  rights are being assigned.
Provided  that the  Purchaser or any Holder and any  transferee  or assignee has
complied  with the  foregoing  conditions,  this  Agreement  shall  survive  any
transfer  of  Registrable  Securities  to and shall  inure to the  benefit of an
Affiliate or such other  successors,  assigns and transferees of the Purchase or
any such  Holder.  In  addition,  and  whether or not any  express  transfer  or
assignment  shall have been made, the provisions of this Agreement which are for
the benefits of the parties  hereto other than the Company shall also be for the
benefit of and enforceable by any subsequent Holder or Registrable Securities.

         14.      Miscellaneous.

                  (a) No Inconsistent Agreements. The Company will not hereafter
enter into any agreement  with respect to its securities  which is  inconsistent
with or violates the rights granted to the Holders in this Agreement.

                  (b) Adjustments Affecting Registrable Securities.  The Company
will not take any  action,  or permit any change to occur,  with  respect to its
securities  that would  adversely  affect the  ability of the Holders to include
such  Registrable  Securities  in a  registration  undertaken  pursuant  to this
Agreement or which would adversely affect the  marketability of such Registrable
Securities in any such registration (including, without limitation,  effecting a
stock split or a combination of shares).

                  (c) Specific Performance;  Other Rights. The parties recognize
that  various of the rights of the  Purchaser  and any other  Holder  under this
Agreement are unique and agree that irreparable  damage would occur in the event
that any of the  provisions of this  Agreement  were not performed in accordance
with their specific terms or were otherwise breached.  Accordingly,  the parties
agree that each of the Purchaser and any such Holder shall,  in addition to such
other remedies as may be available to it at law or in equity,  have the right to
enforce its rights  hereunder  by actions  for  injunctive  relief and  specific
performance  in any  court of the  United  States or any  state  thereof  having
jurisdiction,  to the extent  permitted  by law. The Company  hereby  waives any
requirement  for  security  or the  posting of any bond in  connection  with any
temporary or permanent award of injunctive, mandatory or other equitable relief.


                                     - 17 -

<PAGE>

                  (d)  Severability.   If  any  term,  provision,   covenant  or
restriction of this Agreement is held by a court of competent jurisdiction to be
invalid,  void  or  unenforceable,  the  remainder  of  the  terms,  provisions,
covenants  and  restrictions  of this  Agreement  shall remain in full force and
effect and shall in no way be affected,  impaired or  invalidated.  It is hereby
stipulated  and declared to be the intention of the parties that they would have
executed the remaining terms,  provisions,  covenants,  and restrictions without
including  any of  such  which  may  be  hereafter  declared  invalid,  void  or
unenforceable.

                  (e) Notices. All notices and other communications  required or
permitted  under this Agreement  shall be effective upon receipt and shall be in
writing and may be delivered in person, by telecopy,  overnight delivery service
or registered or certified  United States mail,  addressed to the Company or the
Purchaser (or to any other Holder not a party hereto on the date hereof,  to the
address of such Holder in the stock  record books of the  Company),  as the case
may be, at their respective addresses set forth below:

                                    (i)     If to the Purchaser to:

                                    MILLENNIUM PHARMACEUTICALS, INC.
                                    238 Main Street
                                    Cambridge, Massachusetts  02139-4815
                                    Attn:  Chief Executive Officer
                                    Telephone:  (617) 679-7000
                                    Facsimile:  (617) 621-0264

                                    with a required copy to:

                                    Attention: Legal Department

                                    and to:

                                    Hale and Dorr LLP
                                    60 State Street
                                    Boston, Massachusetts 01209
                                    Attn: Steven Singer
                                    Telephone: (617) 526-6000
                                    Facsimile: (617) 526-5000


                                     - 18 -

<PAGE>

                           (ii)     If to Purchaser to:

                                    BAYER AG
                                    D 51368
                                    Leverkeusen
                                    Federal Republic of Germany
                                    Attn: General Counsel
                                    Telephone: 011 49 214 30 81803
                                    Facsimile:  011 49 214 30 50848

                                    With copies to:

                                    Bayer Corporation, Inc.
                                    400 Morgan Lane
                                    West Haven, CT
                                    Attn: Legal Department
                                    Telephone: (203) 812 - 2401
                                    Facsimile:  (203) 812 - 2795

                                    and to:

                                    Wilmer, Cutler & Pickering
                                    2445 M Street
                                    Washington, DC  20037
                                    Attn: Richard W. Cass
                                    Telephone: (202) 663-6503
                                    Facsimile: (202) 663-6363

All  notices and other  communications  shall be  effective  upon the earlier of
actual  receipt  thereof by the person to whom  notice is directed or (a) in the
case of notices and  communications  sent by personal delivery or telecopy,  one
business  day after  such  notice or  communication  arrives  at the  applicable
address or was successfully sent to the applicable  telecopy number,  (b) in the
case of notices and communications  sent by overnight delivery service,  at noon
(local  time) on the  second  business  day  following  the day such  notice  or
communications  was delivered to such delivery  service,  and (c) in the case of
notices and  communications  sent by United  States mail,  seven days after such
notice or communication shall have been deposited in the United States mail. Any
notice delivered to a party hereunder shall be sent simultaneously,  by the same
means, to such party's counsel as set forth above.

                  (f)  Entire  Agreement.  This  Agreement  contain  the  entire
understanding of the parties with respect to the matters covered hereby.


                                     - 19 -

<PAGE>

                  (g) Amendments  and Waivers.  This Agreement may be amended as
to the  Holders and their  successors  and  assigns  (determined  as provided in
Section 13), and the Company may take any action herein  prohibited,  or omit to
perform any act required to be performed by it, only if the Company shall obtain
the written  consent of the Holders of 75% of the Registrable  Securities.  This
Agreement may not be waived,  changed,  modified, or discharged orally, but only
by an  agreement  in  writing  signed  by the  party  or  parties  against  whom
enforcement  of any waiver,  change,  modification  or discharge is sought or by
parties  with the right to  consent  to such  waiver,  change,  modification  or
discharge on behalf of such party; provided,  however, that any consent required
by the Holders  shall require the consent in writing of no less than the Holders
of 75% of the Registrable Securities.

                  (h) Headings; Counterparts. Headings in this Agreement are for
purposes of reference  only and shall not limit or otherwise  affect the meaning
hereof.  This Agreement may be executed in any number of  counterparts,  each of
which shall be an original,  but all of which together shall  constitute one and
the  same  instrument,  and  shall  become  effective  when  one or  more of the
counterparts  have been signed by each party and delivered to the other parties,
it being understood that all parties need not sign the same counterpart.

                  (i) Gender.  Whenever  used herein the  singular  number shall
include the plural,  the plural shall include the  singular,  and the use of any
gender shall include all genders.

                  (j) Further  Assurances.  Each of the parties hereto agrees to
execute and deliver  those  writings and documents  reasonably  required to more
fully carry out the purposes of this Agreement and the transactions contemplated
hereby.

                  (k)      GOVERNING LAW. THIS AGREEMENT SHALL BE CONSTRUED IN
ACCORDANCE WITH AND GOVERNED BY THE LAWS OF THE STATE OF DELAWARE
WITHOUT REGARD TO CONFLICTS OF LAW PRINCIPLES.

                  (l) No  Third  Party  Beneficiaries.  Except  as  provided  by
Sections 10 and 13,  nothing  contained in this  Agreement is intended to confer
upon any Person other than the parties  hereto and their  respective  successors
and permitted assigns and transferees,  any benefit,  right or remedies under or
by reason of this Agreement.

                  (m)  Consent  to  Jurisdiction.  Each  of the  parties  hereto
irrevocably submits to the personal exclusive  jurisdiction of the United States
District Court for the District of Delaware for the purposes of any suit, action
or  other   proceeding   arising  out  of  this  Agreement  or  any  transaction
contemplated  hereby (and, to the extent  permitted  under  applicable  rules of
procedure, agrees not to commence any action, suit or proceeding relating hereto
except in such court). Each of the parties hereto further agrees that service of
any process,  summons,  notice or document hand  delivered or sent by registered
mail to such  party's  respective  address  set forth in  Section  14(e) will be
effective service of process for any action, suit or proceeding in Delaware with
respect to any matters to which it has submitted to jurisdiction as set forth in
the immediately preceding sentence. Each of the

                                     - 20 -

<PAGE>

parties  hereto  irrevocably  and  unconditionally  waives any  objection to the
laying of venue of any action,  suit or proceeding arising out of this Agreement
or the transactions  contemplated hereby in the United States District court for
the District of Delaware,  and hereby further  irrevocably  and  unconditionally
waives and agrees not to plead or claim in such court that any such action, suit
or proceeding brought in such court has been brought in an inconvenient forum.


                                     - 21 -

<PAGE>

         IN WITNESS WHEREOF,  each of the parties has executed this Agreement or
caused this  Agreement to be executed on its behalf as of the day and year first
above written.



MILLENNIUM PHARMACEUTICALS, INC.              BAYER AG


By: /s/                                       By: /s/
Title:                                        Title:


                                              By: /s/
                                              Title:



                                     - 22 -



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