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SC 13D/A, 2000-07-06
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934
                                (Amendment No. 1)

                        Millennium Pharmaceuticals, Inc.
                        --------------------------------
                                (Name of Issuer)

                                  Common Stock
                                  ------------
                         (Title of Class of Securities)

                                   0005999021
                                   ----------
                                 (CUSIP Number)

                                 George J. Lykos
                               Bayer Corporation
                                400 Morgan Lane
                              Westhaven, CT 06516
                                 (203)-812-2401
             ------------------------------------------------------
                  (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)

                                  July 3, 2000
             -------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of ss.ss. 240.13d-1(e),  240.13d-1(f),  or 240.13d-1(g),  check
the following box. [ ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of this  Schedule,  including all exhibits.  See Rule 240.13d-7 for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).
<PAGE>

CUSIP No.  0005999021                                          Page 2 of 9 Pages

1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
           Bayer AG

2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
           (a) |X|
           (b)[ ]

3          SEC USE ONLY


4          SOURCE OF FUNDS
           WC.

5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
           ITEMS 2(d) OR 2(e)
           [ ]

6          CITIZENSHIP OR PLACE OF ORGANIZATION
           Federal Republic of Germany

                            7        SOLE VOTING POWER
                                     519,480
        NUMBER OF
          SHARES            8        SHARED VOTING POWER
       BENEFICIALLY                  9,395,840
         OWNED BY
           EACH             9        SOLE DISPOSITIVE POWER
        REPORTING                    519,480
          PERSON
           WITH             10       SHARED DISPOSITIVE POWER
                                     9,395,840

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           9,915,320

12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES SHARES
           [ ]

13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           10.6%

14         TYPE OF REPORTING PERSON
           CO

<PAGE>

CUSIP No.  0005999021                                          Page 3 of 9 Pages

1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
           Agfa Holding GmbH

2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
           (a) |X|
           (b) [ ]

3          SEC USE ONLY


4          SOURCE OF FUNDS
           WC.

5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
           ITEMS 2(d) OR 2(e)
           [ ]

6          CITIZENSHIP OR PLACE OF ORGANIZATION
           Federal Republic of Germany

                            7        SOLE VOTING POWER
                                     0
        NUMBER OF
          SHARES            8        SHARED VOTING POWER
       BENEFICIALLY                  9,395,840
         OWNED BY
           EACH             9        SOLE DISPOSITIVE POWER
        REPORTING                    0
          PERSON
           WITH             10       SHARED DISPOSITIVE POWER
                                     9,395,840

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           9,395,840

12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES SHARES
           [ ]

13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           10.0%

14         TYPE OF REPORTING PERSON
           CO

<PAGE>

CUSIP No.  0005999021                                          Page 4 of 9 Pages

Item 1.  Security and Issuer.

                  This  Statement  relates to shares of common stock,  $.001 par
value per share (the "Common  Stock"),  of Millennium  Pharmaceuticals,  Inc., a
Delaware  corporation (the "Issuer"),  which has its principal executive offices
at 238 Main Street, Cambridge, Massachusetts 02139-4815.

Item 2.  Identity and Background.

                  This  Statement is being filed by Bayer AG ("Bayer")  and Agfa
Holding GmbH  ("Agfa"),  each a German  corporation  with its principal  offices
located in Leverkusen,  Germany. Bayer is a German multinational  pharmaceutical
and chemical company.  Agfa is an inactive,  wholly-owned indirect subsidiary of
Bayer.  Information  as to the executive  officers and directors of Bayer is set
forth in Exhibit A hereto  and  information  as to the  executive  officers  and
directors of Agfa is set forth in Exhibit B hereto.

                  During  the past five  years,  neither  Bayer or Agfa nor,  to
Bayer's  knowledge,  any of the  persons  listed  in  Exhibit  A nor,  to Agfa's
knowledge,  any of the  persons  listed in  Exhibit B, has been  convicted  in a
criminal  proceeding  (excluding traffic  violations and similar  misdemeanors).
During the past five years,  neither Bayer or Agfa's nor, to Bayer's  knowledge,
any of the  persons  listed in Exhibit A nor,  to Agfa's  knowledge,  any of the
persons  listed  in  Exhibit  B,  has been a party  to a civil  proceeding  of a
judicial or  administrative  body of competent  jurisdiction  and as a result of
such proceeding was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to, federal
or state securities laws or finding any violation with respect to such laws.

Item 3.  Source and Amount of Funds or Other Consideration.

                  The  source of funds used by Bayer to  purchase  the shares of
Common  Stock was the working  capital of Bayer.  Bayer paid  $96,600,000.00  to
acquire  9,915,320  shares (as  measured  following a  subsequent  2 for 1 stock
split) of Common  Stock  (the  "Shares").  The  source of funds  used by Agfa to
purchase the shares of Common Stock was the working  capital of Agfa.  Agfa paid
Bayer $1,051,159,600 to purchase 9,395,840 shares of Common Stock from Bayer.

Item 4.  Purpose of Transaction.

                  On November 10, 1998 Bayer acquired the Shares  pursuant to an
Investment  Agreement dated September 22, 1998 between Bayer and the Issuer (the
"Investment  Agreement").  Also on  September  22,  1998,  Bayer and the  Issuer
entered  into an agreement  (the  "Collaboration  Agreement")  pursuant to which
Bayer receives  access to key  technologies in modern genome research and a flow
of  genome-based  targets for drug  development  over a five-year  period (which
period could be  shortened or  lengthened  in  accordance  with the terms of the
Collaboration  Agreement) (the "Program  Term").  The Issuer has filed a copy of
the  Collaboration  Agreement  with the SEC as an  exhibit to its report on Form
10-Q for the quarter ended  September  30, 1998.  The  Investment  Agreement has
previously been filed as an Exhibit to this statement on Schedule 13D.

<PAGE>

CUSIP No.  0005999021                                          Page 5 of 9 Pages

                  On July 3, 2000,  Agfa, a  wholly-owned  subsidiary  of Bayer,
purchased  9,395,840  shares of Common Stock from Bayer.  This transfer was made
for internal strategic  restructuring  purposes of Bayer and represents a change
in the form of ownership of the Shares by Bayer.  Pursuant to an Assignment  and
Assumption  Agreement,  Bayer assigned to Agfa, and Agfa assumed, the rights and
obligations under the Investment  Agreement and a Registration  Rights Agreement
described in Item 6 below.

                  Bayer and Agfa  acquired the Shares for  investment  purposes.
Bayer's and Agfa's right to sell the Shares and to acquire  additional shares of
Common Stock is limited by the Investment Agreement (see Item 6 below).  Subject
to the Investment Agreement, Bayer and Agfa intend to review their investment in
the Issuer on a continuing basis and,  depending on various  factors,  including
the  Issuer's  business,  affairs and  financial  position,  other  developments
concerning  the Issuer,  the price level of the Common Stock,  conditions in the
securities  markets and general  economic  and industry  conditions,  as well as
other investment  opportunities  available to Bayer, may in the future take such
actions with respect to their investment in the Issuer as they deems appropriate
in light of the  circumstances  existing  from time to time.  Such  actions  may
include the purchase of additional shares of Common Stock in the open market, in
privately negotiated  transactions or otherwise,  or the sale at any time of all
or a portion of the Shares or other shares of Common Stock hereafter acquired by
Bayer and Agfa to one or more purchasers.

                  Pursuant  to  the  Investment  Agreement  and  subject  to the
limitations  described  therein,  Bayer has the right during the Program Term to
have a  representative  attend  each year two  regular  meetings of the board of
directors of  Millennium,  to receive  copies of agendas and the minutes for all
board  meetings,  and once each quarter to receive a confidential  briefing from
officers  of  Millennium  regarding   Millennium's  business  and  strategy.  In
addition,  Bayer may engage in  communications  with one or more shareholders of
the Issuer, one or more officers of the Issuer and/or one or more members of the
board of  directors  of the  Issuer  and/or one or more  representatives  of the
Issuer regarding the Issuer, including but not limited to its operations.  Bayer
may discuss ideas that,  if effected,  may result in any of the  following:  the
acquisition   by  persons  of  additional   Common  Stock  of  the  Issuer,   an
extraordinary  corporate transaction involving the Issuer, and/or changes in the
board of directors or management of the Issuer.

                  Except  as  described  above,  neither  Bayer nor Agfa has any
current  plans or proposals  that relate to or would result in any of the events
set forth in  paragraphs  (a)  through (j) of Item 4. Bayer and Agfa may, at any
time and from time to time,  review or reconsider  their position  and/or change
their purpose and/or formulate plans or proposals with respect thereto.

<PAGE>

CUSIP No.  0005999021                                          Page 6 of 9 Pages

Item 5.  Interest in Securities of the Issuer.

                  (a),  (b),  (c)  Bayer is the  beneficial  owner of  9,915,320
shares of Common Stock  (approximately 10.6% of the outstanding shares of Common
Stock).  Bayer is the  beneficial  owner of all of the  Shares  and has the sole
power to vote and dispose of 519,480 Shares. Bayer, also controls the voting and
disposition  of all  9,395,840  shares  held by Agfa by virtue  of its  indirect
ownership of 100% of the issued and outstanding  equity  interests of Agfa. Agfa
is the beneficial  owner of 9,395,840  shares and has sole power (subject to the
control by Bayer) to vote and dispose of all such shares.  On November 10, 1998,
Bayer  acquired  the Shares from the Issuer for an aggregate  purchase  price of
$96,600,000,  or $19.485 per share (on a pre-split basis), pursuant to the terms
of the Investment  Agreement.  On July 3, 2000, Agfa acquired  9,395,840  shares
from Bayer for an aggregate  purchase  price of  $1,051,159,600, or $111.875 per
share.

                  (d), (e)   Not applicable.


Item 6.  Contracts, Arrangements, Understandings or Relationships with Respect
to the Issuer.

                  (i) On September  22, 1998,  the Issuer and Bayer entered into
the Investment Agreement,  (the "Investment  Agreement")  previously filed as an
Exhibit  to this  Statement  on  Schedule  13D.  Agfa  assumed  the  rights  and
obligations of Bayer to the extent they pertain to the shares acquired by Agfa.

                  Bayer  has  certain   subscription   rights  pursuant  to  the
Investment Agreement (as more fully described therein). So long as Bayer has not
sold more than 1,000,000 Shares (as adjusted to reflect any stock splits,  stock
dividends and similar  recapitalizations)  (other than sales to affiliates),  if
the Issuer proposes the issuance of certain new securities,  then, prior to each
such issuance of such new securities, the Issuer shall offer to Bayer a pro rata
share of such new securities.  These subscription rights will terminate upon the
earlier of (i) a sale of all or  substantially  all of the assets or business of
the Issuer, by merger,  sale of assets or otherwise,  or (ii) termination of the
Program Term.

<PAGE>

CUSIP No.  0005999021                                          Page 7 of 9 Pages

                  Pursuant  to the  Investment  Agreement,  prior  to the  third
anniversary   of  Bayer's   purchase  of  the  Shares,   except  under   certain
circumstances as more fully described in the Investment Agreement, Bayer and its
affiliates (i) will not acquire any direct or indirect  beneficial  ownership or
interest  in any  additional  securities  of  the  Issuer,  and  (ii)  will  not
participate  in the  solicitation  of proxies to vote  securities of the Issuer.
Prior to the second anniversary of such purchase,  Bayer will not sell, transfer
or otherwise dispose of any Shares (except to any affiliate of Bayer). After the
second  anniversary  of the Closing and prior to the  expiration  of the Program
Term, Bayer will not sell, transfer or otherwise dispose of, in any one calendar
year, more than 2,500,000 Shares (as adjusted to reflect any stock splits, stock
dividends  and similar  recapitalizations)  (except to an  affiliate  of Bayer).
After the second  anniversary  of the Closing and prior to the expiration of the
Program  Term,  if Bayer  proposes to sell any Shares  other than  pursuant to a
registration  statement  under the Securities Act, the Issuer shall have a right
of first negotiation with respect to the acquisition of those Shares proposed to
be sold.  The  foregoing  restrictions  on transfer of the Shares  expire  under
certain circumstances more fully described in the Investment Agreement.

                  The  description of the  Investment  Agreement is qualified in
its  entirety by  reference to such  agreement,  a copy of which was  previously
filed as an exhibit to this statement on Schedule 13D.

                  (ii) On November 10, 1998,  the Issuer and Bayer  entered into
the Registration Rights Agreement,  (the "Registration  Rights Agreement") which
was previously filed as an exhibit to this statement on Schedule 13D. Pursuant
to the  Registration  Rights  Agreement  the Issuer has agreed to provide  Bayer
certain demand and piggyback registration rights for the shares.  Pursuant to an
Assignment and Assumption  Agreement dated July 3, 2000, Agfa assumed the rights
and obligations of Bayer under the  Registration  Rights Agreement to the extent
they  pertain to the  shares  acquired  by Agfa.  A copy of the  Assignment  and
Assumption  Agreement is attached as Exhibit C to this amendment to statement on
Schedule 13D.

                  Bayer and Agfa  together  have the  right,  subject to certain
exceptions, to two demand registrations on any registration form that the Issuer
chooses and which the Issuer is  eligible to use.  Bayer and Agfa may not demand
registration of securities  prior to the second  anniversary of the closing date
of the  Investment  Agreement.  The Issuer may postpone  (or  withdraw) a demand
registration,  under the  circumstances  specified  in the  Registration  Rights
Agreement.

<PAGE>

CUSIP No.  0005999021                                          Page 8 of 9 Pages

                  Also pursuant to the Registration Rights Agreement,  Bayer has
certain  piggyback  registration  rights.  If the Issuer at any time proposes to
register any of its securities  under the Securities Act (other than pursuant to
a demand  registration or a Special  Registration as defined in the Registration
Rights  Agreement),  whether  or not for sale for its own  account  (a  "Company
Registration"),  upon the  written  request  of  Bayer,  the  Issuer  shall  use
reasonable  best efforts to cause all Shares that the Issuer has been  requested
by Bayer to register to be so registered  under the Securities Act to the extent
necessary to permit their disposition in accordance with the intended methods of
distribution specified in the request by Bayer.

                  The  description  of  the  Registration  Rights  Agreement  is
qualified in its entirety by  reference to such  agreement,  a copy of which was
previously filed as an exhibit to this Statement on Schedule 13D.


Item 7.  Material to be Filed as Exhibits.


               Exhibit A                Information concerning Bayer's executive
                                        officers and directors.
               Exhibit B                Information concerning Agfa's executive
                                        officers and directors.
               Exhibit C                Assignment and Assumption Agreement
                                        dated July 3, 2000, between Bayer and
                                        Agfa.
               Exhibit D                Joint Filing Agreement and Power of
                                        Attorney




<PAGE>

CUSIP No.  0005999021                                          Page 9 of 9 Pages



                                    Signature

    After  reasonable  inquiry and to the best of my  knowledge  and  belief,  I
certify that the  information  set forth in this  amendment to this statement is
true and correct.

Date:  July 6, 2000                          Bayer AG


                                             By:  /s/  Roger J. Patterson
                                                  Roger J. Patterson
                                                  Attorney-in-fact


                                             Agfa Holding GmbH


                                             By:  /s/  Roger J. Patterson
                                                  Roger J. Patterson
                                                  Attorney-in-fact


<PAGE>


                                                                       Exhibit A

                  DIRECTORS AND EXECUTIVE OFFICERS OF BAYER AG


                  The following table sets forth the name and present  principal
occupation or employment of each member of the  Supervisory  Board and the Board
of  Management  of Bayer AG. The  business  address of each of them is Bayer AG,
Leverkusen,  Germany.  Except  as  otherwise  indicated,  all such  persons  are
citizens of Germany and each  occupation  listed refers to employment with Bayer
AG.


                                   Supervisory Board

Name:                         Principal Present Occupation

Hermann Josef Strenger        Chairman of the Supervisory Board, Former Chairman
                              of the Company's Board of Management

Rolf Nietzarad                Chemical Laboratory Technician

Dr. h.c. Martin Kohlhaussen   Chairman of the Board of Managing Directors of
                              Commerzbank AG, Frankfurt (Main)

Hilmar Kopper                 Chairman of the Supervisory Board of Deutsche Bank
                              AG,  Frankfurt (Main)

Dr. -Ing. Manfred Lennings    Management Consultants, Essen-Kettwig

Dr. h.c. Andre Leysen         Chairman of the Board of Directors of Gevaert
(Citizen of Belgium)          N.V., Mortsel, Belgium

<PAGE>

Dr. h.c. Helmut Oswald        President and Chief Executive Officer of Nestle
Maucher                       S.A., Vevey, Switzerland

Dieter Meinhardt              Machine Fitter, Dormagen

Dr. Heinrich von Pierer       Chairman of the Board of Management of Siemens AG,
                              Munich

Waltraud Schlaefke            Chemical Laboratory Technician, Walsrode

Hubertus Schmoldt             Chairman of the German Mine, Chemical and Power
                              Workers Union, Hannover

Dieter Schulte                Chairman of the German Unions Federation (DGB),
                              Dusseldorf

Lodewijk C. van Wachem        Chairman of the Supervisory Board of Royal Dutch
(Citizen of the Netherlands)  Petroleum Company, The Hague, Netherlands

Prof. Dr. Ernst-Ludwig        President of the German Research Association, Bonn
Winnacker

Dr. Hermann Wunderlich        Former Vice Chairman of the Company's Board of
                              Management, Odenthal

Erhard Gipperich              Vice Chairman of the Supervisory Board, Lathe
                              operator, Leverkusen

Dr. Klaus Alberti             Chemist, Leverkusen

Petra Brayer                  Chemical Laboratory Assistant, Dormagen

Karl-Josef Ellrich            Health Fund Business Consultant

Detlef Fahlbusch              North Rhine District Secretary of the German Mine,
                              Chemical and Power Workers' Union

<PAGE>

                               Board of Management


Name:                         Principal Present Occupation


Dr. Manfred Schneider         Chairman of the Board of Management

Dr. Pol Bamelis               Member of the Board of Management
(Citizen of Belgium)

Dr. Udo Oels                  Member of the Board of Management

Werner Spinner                Member of the Board of Management

Werner Wenning                Member of the Board of Management

Dr. Attila Molnar             Member of the Board of Management

Dr. Frank Morich              Member of the Board of Management

Dr. Gottfried Zaby            Member of the Board of Management



<PAGE>

                                                                       Exhibit B


              Directors and Executive Officers of Agfa Holding GmbH



                  The following table sets forth the name and present  principal
         occupation  or  employment  of the  Managing  Directors of Agfa Holding
         GmbH.  The  business  address of each of them is Bayer AG,  Leverkusen,
         Germany. All such persons are citizens of Germany.



         Name:                              Principal Present Occupation

         Dr. Hubertus Behncke               Senior Counsel, Bayer AG

         Klaus Kuhn                         Head of Finance Department, Bayer AG



<PAGE>

                                                                       Exhibit C


                       ASSIGNMENT AND ASSUMPTION AGREEMENT

         THIS ASSIGNMENT AND ASSUMPTION  AGREEMENT is made and entered into this
3rd day of July,  2000,  by and among  Bayer  AG, a  corporation  organized  and
existing  under  the  laws of  Germany  ("Assignor")  and AGFA  Holdings  GmbH a
corporation organized and existing under the laws of Germany ("Assignee").

                                    RECITALS:

                  WHEREAS,  Assignor is a party to an Investment  Agreement (the
"Investment  Agreement")  dated as of September 22, 1998 by and between Assignor
and  Millennium  Pharmaceuticals,  Inc., a Delaware  corporation  ("Millennium")
pursuant to which the Assignor  acquired four million,  nine hundred fifty seven
thousand, six hundred sixty (4,957,660) shares of the common stock of Millennium
(which  have  since been  converted  into nine  million,  nine  hundred  fifteen
thousand,  three hundred and twenty shares  (9,915,320) as a result of a two for
one  stock  split  (the  "Shares")  and a  Registration  Rights  Agreement  (the
"Registration  Rights  Agreement")  dated as of  November  10, 1998 by and among
Millennium and Assignor relating to the Shares.

                  WHEREAS,  the Investment  Agreement provides that the Assignor
may assign its rights  thereunder to an Affiliate (as defined in the  Investment
Agreement) of Assignor provided that the Affiliate agrees in writing to be bound
by the terms and conditions set forth in the Investment Agreement.

                  WHEREAS,  the  Registration  Rights  Agreement  provides  that
Assignor  may assign  its rights  thereunder  to any  Affiliate  or to any other
successors,  assignee or  transferees  of the  Assignor or any other  Holder (as
defined in the Registration  Rights Agreement) provided that Millennium is given
written  notice from the Assignor at the time of such transfer  stating the name
and address of the transferee or assignee and  identifying  the securities  with
respect to which the rights under the  Registration  Rights  Agreement are being
transferred and provided that the transferee or assign agrees, in writing,  upon
request of Millennium to be bound by the provisions of the  Registration  Rights
Agreement.

                  WHEREAS,  the Assignee is an Affiliate of the Assignor as that
term  is  defined  in the  Investment  Agreement  and  the  Registration  Rights
Agreement.

<PAGE>

                  WHEREAS, the Assignor is transferring  9,395,840 of the Shares
(the  "Transferred  Shares")  to the  Assignee  as of the  date  hereof  and the
Assignor  wishes to assign to the Assignee,  and the Assignee  agrees to assume,
the rights and  obligations of the Assignor  under the Investment  Agreement and
the Registration Rights Agreement with respect to the Transferred Shares.

                  NOW,  THEREFORE,  for good  and  valuable  consideration,  the
receipt and  sufficiency of which are hereby  acknowledged,  the parties hereto,
intending to be legally bound, agree as follows:

                  1. Assignment.  Assignor hereby assigns,  transfers,  and sets
over unto  Assignee all of the rights and benefits of Assignor in, to, and under
the Investment  Agreement and the Registration  Rights Agreement as they pertain
to the  Transferred  Shares and  retains  all such  rights and  benefits as they
pertain to the remaining Shares.

                  2.  Acceptance  and  Assumption.  Assignee  hereby accepts the
assignment of the Investment  Agreement and the  Registration  Rights  Agreement
with  respect to the  Transferred  Shares and agrees to assume,  and hereby does
assume,  and  agrees to be bound by the terms  and  conditions  set forth in the
Investment  Agreement and the  Registration  Rights Agreement as they pertain to
the Transferred Shares.

                  3.     Notice.  Assignor agrees to provide Millennium the
written notice required by the Registration Agreement, along with a copy of this
Assignment  and  Assumption  Agreement,  concurrent  with the  execution of this
Agreement.

                  4.  Further  Assurances.  From  time to time  after  the  date
hereof,  each of the parties shall,  upon request by the other party and without
further  consideration,   execute,   acknowledge  and  deliver  all  such  other
instruments of sale,  assignment,  conveyance  and transfer,  and shall take all
such other  commercially  reasonable action, in each case to the extent required
to give  effect  to the  transactions  in  accordance  with  the  terms  of this
Assignment and Assumption Agreement.

<PAGE>

                  IN WITNESS  WHEREOF,  the parties  hereto have  executed  this
Assignment and Assumption Agreement as of the date first set forth above.


                                             Bayer AG


                                             By:       /s/ Joachim Reinders
                                             Name:     Joachim Reinders
                                             Title:    Head of Tax Department


                                             By:       /s/ Helmut Pastor
                                             Name:     Helmut Pastor
                                             Title:    Senior Counsel



                                             AGFA Holdings GmbH


                                             By:       /s/ Dr. Hubertus Behncke
                                             Name:     Dr. Hubertus Behncke
                                             Title:    Managing Director




<PAGE>

                                                                       Exhibit D


                             JOINT FILING AGREEMENT
                                       AND
                                POWER OF ATTORNEY


         The  undersigned  hereby  agree to jointly file a statement on Schedule
13D,  together with any amendments  thereto  (collective,  the "Schedule 13Ds"),
with the Securities and Exchange Commission pursuant to the requirements of Rule
13d-1(k) under the Securities Exchange Act of 1934, as amended.

Each of the undersigned also appoints:

                               Roger J. Patterson

with full power of substitution, as its true and lawful attorney-in-fact for the
specific purpose of executing on their respective  behalf statements on Schedule
13D or  Schedule  13G  relating  to their  ownership  of  shares  of  Millennium
Pharmaceuticals, Inc., together with any amendments thereto.

This joint filing  Agreement and Power of Attorney may be signed in  counterpart
copies.

Date:  July 3rd 2000                         Bayer AG


                                             By:       /s/ Joachim Reinders
                                             Name:     Joachim Reinders
                                             Title:    Head of Tax Department


                                             By:       /s/ Helmut Pastor
                                             Name:  Helmut Pastor
                                             Title:    Senior Counsel



Date:  July 3rd 2000                         AGFA Holdings GmbH


                                             By:       /s/ Dr. Hubertus Behncke
                                             Name:     Dr. Hubertus Behncke
                                             Title:    Managing Director




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