PDT INC /DE/
10-Q, 1996-11-12
PHARMACEUTICAL PREPARATIONS
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<PAGE>


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-Q


|X|        QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE
           SECURITIES EXCHANGE ACT OF 1934

                For the quarterly period ended September 30, 1996

                                       or

|_|        TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE
           SECURITIES EXCHANGE ACT OF 1934

                         Commission File Number: 0-25544

                                    PDT, INC.
- --------------------------------------------------------------------------------
             (Exact name of Registrant as specified in its charter)


           Delaware                              77-0222872
- --------------------------------------------------------------------------------
(State or other jurisdiction of           (IRS Employer Identification No.)
incorporation or organization)

             7408 Hollister Avenue, Santa Barbara, California 93117
- --------------------------------------------------------------------------------
          (Address of principal executive offices, including zip code)

                                 (805) 685-9880
- --------------------------------------------------------------------------------
              (Registrant's telephone number, including area code)


           Indicate  by check  mark  whether  the  Registrant  (1) has filed all
reports  required to be filed by Section 13 or 15(d) of the Securities  Exchange
Act of 1934 during the preceding 12 months (or for such shorter  period that the
Registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. Yes |X| No |_|

           Indicate  the number of shares  outstanding  of each of the  issuer's
classes of common stock, as of the latest practicable date.

           Class                           Outstanding at October 31, 1996
           -----                           -------------------------------
    Common Stock, $.01 par value                     12,463,769




<PAGE>



                                    PDT, INC.

                                    Form 10-Q

                                TABLE OF CONTENTS


                                                                        PAGE NO.
                                                                        --------

TABLE OF CONTENTS ....................................................       2

PART I   FINANCIAL INFORMATION

         ITEM 1.   Consolidated Financial Statements
         Consolidated balance sheets as of September 30, 1996 and
              December 31, 1995 ......................................       3
         Consolidated statements of operations for the three months
              ended September 30, 1996 and 1995, and for the nine
              months ended September 30, 1996 and 1995 ................      4
         Consolidated statements of cash flows for the nine months
              ended September 30, 1996 and 1995 .......................      5
         Notes to consolidated financial statements ...................      6

         ITEM 2.   Management's discussion and analysis of financial
                   condition and results of operations ................      7

PART II. OTHER INFORMATION

         ITEM 4    Submission of matters to a vote of security
                   holders ............................................      12

         ITEM 6.   Exhibits and reports on Form 8-K ...................      12

SIGNATURES ............................................................      13


<PAGE>

<TABLE>
<CAPTION>

                                                     Part 1. FINANCIAL INFORMATION
ITEM 1.  FINANCIAL STATEMENTS
                                              PDT, INC.
                                     CONSOLIDATED BALANCE SHEETS

                                                                  SEPTEMBER 30,      DECEMBER 31,
                                                                     1996               1995
                                                                ----------------   ----------------
                                                                   (Unaudited)
                              ASSETS
<S>                                                             <C>                <C>
Current assets:
   Cash and cash equivalents ..................................   $  40,816,000    $   8,886,000
   Investments in short term marketable securities ............      20,100,000             --
   Accounts receivable ........................................       1,884,000           11,000
   Inventory-finished goods ...................................          15,000           10,000
   Prepaid expenses and other current assets ..................         533,000          385,000
                                                                  -------------    -------------
Total current assets ..........................................      63,348,000        9,292,000

Property, plant & equipment:
   Vehicles ...................................................          28,000
   Furniture and fixtures .....................................         552,000          336,000
   Equipment ..................................................       2,194,000        1,630,000
   Leasehold improvements .....................................       1,111,000          666,000
   Capital lease equipment ....................................         184,000          184,000
                                                                  -------------    -------------
                                                                      4,069,000        2,816,000
   Accumulated depreciation and amortization ..................      (1,609,000)      (1,210,000)
                                                                  -------------    -------------
                                                                      2,460,000        1,606,000
Patents and other assets ......................................         278,000          361,000
                                                                  -------------    -------------
Total assets ..................................................      66,086,000       11,259,000
                                                                  =============    =============

               LIABILITIES AND SHAREHOLDERS' EQUITY
 Current liabilities:
   Accounts payable ...........................................       2,049,000        2,468,000
   Accrued payroll and expenses ...............................         416,000          331,000
   Current portion of long term obligations ...................          51,000           51,000
   Current portion of capital lease obligations ...............          38,000           39,000
                                                                  -------------    -------------
Total current liabilities .....................................       2,554,000        2,889,000

Long term obligations, less current portion ...................          17,000           47,000
Capital lease obligations, less current portion ...............          31,000           63,000
Convertible notes payable .....................................            --             93,000

Shareholders' equity:
   Common stock, 50,000,000 shares authorized;  12,447,144 and 
      10,401,358 shares issued and outstanding at September 30,
      1996 and December 31, 1995, respectively ................     112,550,000       50,188,000
   Deferred compensation ......................................      (1,924,000)      (7,518,000)
   Accumulated deficit ........................................     (47,142,000)     (34,503,000)
                                                                  -------------    -------------
Total shareholders' equity ....................................      63,484,000        8,167,000
                                                                  -------------    -------------
Total liabilities and shareholders'  equity ...................   $  66,086,000    $  11,259,000
                                                                  =============    =============


SEE ACCOMPANYING NOTES.

</TABLE>


<PAGE>


                                                      PDT, INC.
                                         CONSOLIDATED STATEMENT OF OPERATIONS
                                                   (Unaudited)

<TABLE>
<CAPTION>

                                                   THREE MONTHS ENDED SEPTEMBER 30,   NINE MONTHS ENDED SEPTEMBER 30,
                                                         1996              1995            1996                1995
                                                   ---------------  --------------  ----------------  ---------------
<S>                                                <C>              <C>             <C>                <C>
Revenues:
   Product sales ..............................    $        1,000   $      14,000   $        5,000    $      26,000
   Grants, licensing, and royalty income ......           844,000         129,000        2,225,000          309,000
                                                   ---------------  --------------  ---------------   --------------
                                                          845,000         143,000        2,230,000          335,000
Costs and expenses:
   Cost of goods sold .........................             1,000          22,000            5,000           55,000
   Research and development ...................         4,002,000       1,910,000       12,052,000        4,698,000
   Selling, general and administrative ........         1,844,000         945,000        4,351,000        2,403,000
                                                   ---------------  --------------  ---------------   --------------
Total costs and expenses ......................         5,847,000       2,877,000       16,408,000        7,156,000

Loss from operations ..........................        (5,002,000)     (2,734,000)     (14,178,000)      (6,821,000)

Other income (expense):
   Interest income ............................           856,000         106,000        1,566,000          134,000
   Interest expense ...........................            (9,000)        (40,000)         (27,000)        (139,000)
                                                   ---------------  --------------  ---------------   --------------
Total other income (expense) ..................           847,000          66,000        1,539,000           (5,000)

Net loss ......................................     $  (4,155,000)  $  (2,668,000)  $  (12,639,000)   $  (6,826,000)
                                                    ==============  ==============  ===============   ==============
Net loss per share ............................     $       (0.33)  $       (0.26)  $        (1.10)   $       (0.71)
                                                    ==============  ==============  ===============   ==============
Shares used in computing net loss per share ...        12,438,069      10,283,104       11,519,785        9,679,164
                                                    ==============  ==============  ===============   ==============





SEE ACCOMPANYING NOTES.

</TABLE>



<PAGE>




                                                        PDT, INC.
                                           CONSOLIDATED STATEMENT OF CASH FLOWS
                                                      (Unaudited)
<TABLE>
<CAPTION>


                                                                           NINE MONTHS ENDED SEPTEMBER 30,
                                                                                1996               1995
                                                                          ---------------    --------------
<S>                                                                       <C>                <C>

OPERATING ACTIVITIES:
    Net loss ...........................................................  $  (12,639,000)    $  (6,826,000)
    Adjustments to reconcile net loss to net cash used by operating
    activities:
       Depreciation and amortization ...................................         412,000           428,000
       Amortization of deferred compensation ...........................       1,961,000         1,026,000
       Changes in operating assets and liabilities:
          Accounts receivable ..........................................      (1,873,000)          (63,000)
          Inventories ..................................................          (5,000)           12,000
          Prepaid expenses and other assets ............................         (78,000)           60,000
          Accounts payable and accrued payroll and expenses ............        (334,000)          (71,000)
                                                                          ---------------    --------------

    Net cash used in operating activities ..............................     (12,556,000)       (5,434,000)

    INVESTING ACTIVITIES:
    Purchases and maturities of short term marketable securities, net ..     (20,100,000)                -
    Purchases of property, plant, and equipment ........................      (1,253,000)         (503,000)
                                                                          ---------------    --------------
    Net cash used in investing activities ..............................     (21,353,000)         (503,000)

    FINANCING ACTIVITIES:
    Proceeds from issuance of Common Stock, less issuance costs ........      66,152,000        16,886,000
    Purchase of Treasury Stock .........................................        (250,000)                -
    Proceeds from notes payable ........................................               -         1,230,000
    Payments of notes payable ..........................................               -        (1,230,000)
    Payments of long term obligations ..................................         (30,000)          (35,000)
    Payments of capital lease obligations ..............................         (33,000)          (29,000)
    Proceeds from line of credit .......................................               -         3,600,000
    Payments of line of credit .........................................               -       ( 4,600,000)
                                                                          ---------------    --------------
    Net cash provided by financing activities ..........................      65,839,000        15,822,000

    Net increase (decrease) in cash and cash equivalents ...............      31,930,000         9,885,000

    Cash and cash equivalents at beginning of period ...................       8,886,000         1,483,000
                                                                          ---------------    --------------
    Cash and cash equivalents at end of period .........................  $   40,816,000    $   11,368,000
                                                                          ===============   ===============

    SUPPLEMENTAL DISCLOSURES:
    State taxes paid ...................................................  $       12,000    $        8,000
                                                                          ===============   ===============
    Interest paid ......................................................  $       27,000    $      203,000
                                                                          ===============   ===============


SEE ACCOMPANYING NOTES.

</TABLE>


<PAGE>



                                    PDT, INC.

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                               September 30, 1996
                                   (Unaudited)



1.   Basis of Presentation 

     The information  contained herein has been prepared in accordance with Rule
     10-01of  Regulation S-X. The information at September 30, 1996, and for the
     three month and nine month  periods  ended  September 30, 1996 and 1995, is
     unaudited.  In the opinion of  management,  the  information  reflects  all
     adjustments  necessary  to make the results of  operations  for the interim
     periods a fair statement of such operations.  All such adjustments are of a
     normal recurring nature.  Interim results are not necessarily indicative of
     results  for a full year.  For a  presentation  including  all  disclosures
     required by  generally  accepted  accounting  principles,  these  financial
     statements  should be read in  conjunction  with the  audited  consolidated
     financial  statements  for the year ended December 31, 1995 included in the
     PDT, Inc. Annual Report on Form 10-K filed with the Securities and Exchange
     Commission. 

2.   Per Share Data

     Net loss per share is computed using the weighted  average number of shares
     outstanding  during the periods,  as adjusted  pursuant to the rules of the
     Securities  and  Exchange   Commission   for  certain   matters  for  which
     adjustments would not be required to be presented under APB Opinion 15, for
     the periods prior to the Company's public  offerings.  All stock,  warrant,
     and option  data  included in the  consolidated  financial  statements  and
     footnotes  reflect  the  effect of the  three-for-two  stock  split for all
     periods presented.

3.   Marketable Securities

     Marketable securities are classified as available-for-sale  and are carried
     at market value.  Unrealized gains and losses are reported in shareholders'
     equity. Realized gains and losses on investment transactions are recognized
     when realized  based on settlement  dates and recorded as interest  income.
     Interest and dividends on securities are recognized when earned.  There was
     no unrealized gain or loss recorded as of September 30, 1996. 

<PAGE>


ITEM 2.    MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
                     RESULTS OF OPERATIONS

           The  following  discussion  should  be read in  conjunction  with the
consolidated  financial  statements and notes thereto.  This Quarterly Report on
Form 10-Q may be deemed to include forward looking statements within the meaning
of Section 27A of the  Securities  Act of 1933 and Section 21E of the Securities
Exchange  Act of 1934 that involve risk and  uncertainty,  including  financial,
clinical,  business  environment  and trend  projections.  Although  the Company
believes that its expectations are based on reasonable assumptions,  it can give
no assurance that its goals will be achieved.  The important  factors that could
cause  actual  results to differ  materially  from those in the forward  looking
statements herein include, without limitation, the early stage of development of
both the Company and its products, the timing and uncertainty of results of both
research  and  regulatory   processes,   the  extensive  government   regulation
applicable to the Company's  business,  the unproven  safety and efficacy of the
Company's  drug  and  device  products,  the  Company's  significant  additional
financing  requirements,  the uncertainty of future capital funding,  the highly
competitive environment of the international  pharmaceuticals and medical device
industries  and the  presence  of a number  of  competitors  with  significantly
greater  financial,  technical  and  other  resources  and  extensive  operating
histories,  the  Company's  potential  exposure to product  liability or recall,
uncertainties  relating to patents and other  intellectual  property,  including
whether the Company will obtain sufficient  protection or competitive  advantage
therefrom,  and the Company's  dependence upon a limited number of key personnel
and consultants and its significant reliance upon its collaborative partners for
achieving its goals.


GENERAL

           Since its inception,  PDT, Inc. ("the Company") has been  principally
engaged in the research and development of drugs and medical device products for
use in  photodynamic  therapy.  The  Company  has been  unprofitable  since  its
founding and has incurred a cumulative net loss of  approximately  $47.1 million
as of September 30, 1996. The Company  expects to continue to incur  substantial
and increasing  operating losses for the next several years due to continued and
increased  spending  on  research  and  development  programs,  the  funding  of
preclinical  and clinical  testing and  regulatory  activities  and the costs of
manufacturing and administrative activities.

           The Company's revenues primarily reflect income earned from licensing
agreements, contracts, grants and device product sales,. Product sales represent
limited sales of photodynamic therapy devices (e.g., light producing devices and
light  delivery  and   measurement   devices),   sold  both   domestically   and
internationally, to researchers and an OEM distributor. To date, the Company has
received  no  revenue  from the sale of drug  products,  and the  Company is not
permitted to engage in commercial  sales of drugs or devices until such time, if
ever, as the Company receives requisite regulatory  approvals.  As a result, the
Company does not expect to record significant product sales until such approvals
are received.

           Until the Company commercializes its product(s),  the Company expects
revenues to continue to be attributed to licensing agreements, contracts, grants
and device product sales for research use. The Company  anticipates  that future
revenues and results of  operations  will  continue to  fluctuate  significantly
depending on, among other factors,  the timing and outcome of  applications  for
regulatory approvals, the Company's ability to successfully manufacture,  market
and distribute its drug products and device products and/or the establishment of
collaborative arrangements for the manufacturing,  marketing and distribution of
some of its products.

           The Company has  initiated  Phase III clinical  trials using its drug
SnET2 for  AIDS-related  Kaposi's  sarcoma,  basal cell  carcinoma and cutaneous
metastatic  breast  cancer.  In May 1996,  the Company began Phase I/II clinical
studies  in  ophthalmology,  using  SnET2 to  treat  complications  of  advanced
age-related  macular  degeneration  (AMD),  a leading  cause of  blindness.  The
Company has submitted an  Investigational  New Drug  application with the FDA to
start  clinical  trials with SnET2 for Benign  Prostatic  Hyperplasia,  a common
urologic  condition in men. The Company is also in various stages of preclinical
testing  of SnET2  and other  photoreactive  drugs  for the  treatment  of other
cancers,   certain   cardiovascular   conditions,   urologic,   gynecologic  and
dermatologic conditions and eye disorders.

           The Company has awarded stock options that vest upon the  achievement
of certain  milestones.  Under Accounting  Principles Board Opinion No. 25, such
options  are  accounted  for as  variable  stock  options.  As such,  until  the
milestone is achieved (but only after it is determined to be probable), deferred
compensation  is recorded in an amount equal to the difference  between the fair
market  value of the Common Stock on the date of  determination  less the option
exercise  price and is adjusted from period to period to reflect  changes in the
market  value of the Common  Stock.  Deferred  compensation,  as it relates to a
particular  milestone,  is amortized over the period between when achievement of
the  milestone  becomes  probable  and when the  milestone  is  estimated  to be
achieved.  Amortization  of deferred  compensation  could result in  significant
additional  compensation  expense being  recorded in future periods based on the
market value of the Common Stock from period to period.

           Effective June 21, 1996, the  Compensation  Committee of the Board of
Directors  adjusted the future  vesting  periods of the variable  stock  options
covering  400,000  shares of Common  Stock.  These  variable  stock options were
adjusted  to change  the  vesting  periods to  specific  dates as opposed to the
original vesting periods which were based upon the achievement of milestones; no
change was made to the exercise  prices of these variable  stock  options.  This
change in the vesting  periods  provides for the options to be accounted  for as
non-variable   options  and   therefore   alleviates   the  impact  of  deferred
compensation  expense  fluctuating in future periods based on the changes in the
per share  market  value period to period.  As of  September  30, 1996,  options
covering  177,500  shares with an exercise price of $34.75 per share have vested
and 50,000  shares  are  expected  to vest  during the  remainder  of 1996.  The
remaining unvested shares will vest in the years 1997 through 2000.


RESULTS OF OPERATIONS

           The following table provides a summary of the Company's  revenues for
the three and nine months ended September 30, 1996 and 1995.

<TABLE>
<CAPTION>

                              THREE MONTHS ENDED              NINE MONTHS ENDED
                                SEPTEMBER 30,                   SEPTEMBER 30,
CONSOLIDATED REVENUES          1996          1995            1996            1995
- ---------------------    -------------   ------------   --------------   -----------
<S>                      <C>              <C>           <C>              <C>

Product sales .........   $      1,000   $     14,000   $        5,000   $    26,000
Grants and contracts ..        206,000        129,000          462,000       270,000
Royalties .............         24,000           --             28,000        39,000
License ...............        614,000           --          1,735,000          --
                          ------------   ------------    -------------   -----------

Total revenue .........   $    845,000   $    143,000   $    2,230,000   $   335,000
                          ============   ============   ==============   ===========

</TABLE>

           REVENUES.  For the three months ended  September  30, 1996,  revenues
increased to $845,000  from  $143,000 in the three months  ended  September  30,
1995.  Total revenues for the nine months ended  September 30, 1996 increased to
$2.23 million from  $335,000 in the first nine months of 1995.  The increase for
the three  months  ended  September  30, 1996 relates to the increase in license
income  which was  $614,000 in 1996  compared to no license  income for the same
period of the prior year. Additionally, license income for the nine months ended
September 30, 1996 was $1.74 million  compared to no license income for the same
period in 1995. The increases in license income are due to the  commencement  in
1996 of the  billing for the  reimbursement  of  clinical  costs  related to the
Pharmacia & Upjohn, Inc. ("Pharmacia & Upjohn") license agreement. For the three
months ended  September  30,  1996,  grant  income  increased  to $206,000  from
$129,000 in the three months ended September 30, 1995. Grant income for the nine
months ended  September  30, 1996  increased to $462,000  from  $270,000 for the
comparable period of the prior year.

           COST OF GOODS  SOLD.  Cost of goods sold for the three  months  ended
September  30, 1996  decreased to $1,000 from $22,000 for the three months ended
September 30, 1995. For the nine months ended  September 30, 1996, cost of goods
sold  decreased  to $5,000 from  $55,000 in the first nine  months of 1995.  The
decreases  are due to the  decrease  in product  sales  during 1996 based on the
Company's  decision to allocate its  manufacturing  resources to  supporting  it
preclinical and clinical testing..

           RESEARCH AND  DEVELOPMENT.  The  Company's  research and  development
expenses for the three months ended September 30, 1996 increased to $4.0 million
from $1.91 million in the three months ended  September  30, 1995.  Research and
development  expenses for the nine months ended  September 30, 1996 increased to
$12.05  million from $4.7 million for the nine months ended  September 30, 1995.
The increase in expense for the three and nine month periods ended September 30,
1996  compared to the same periods in 1995 relate  primarily to the  significant
increase  in costs  associated  with the  development  of drug  formulation,  an
increase in the purchase of raw materials and supplies used in the production of
clinical  devices and drug product in  connection  with  clinical  trials and an
increase  in  payroll  costs  due to the  growth  of  research  and  development
personnel and  increased  clinical  trial costs.  The Company  anticipates  that
future  research  and  development  expenses,  as well as other  expenses,  will
increase  significantly  during the  remainder of 1996 and beyond as the Company
expands its  research  and  development  programs,  which  include the hiring of
personnel and the continued expansion of preclinical and clinical testing.

           SELLING,  GENERAL AND ADMINISTRATIVE.  The Company's selling, general
and  administrative  expenses  for the three  months  ended  September  30, 1996
increased to $1.84 million from $945,000 in the three months ended September 30,
1995.  Total selling,  general and  administrative  expenses for the nine months
ended  September  30, 1996  increased to $4.35 million from $2.4 million for the
nine months ended September 30, 1995. These increases are due to increased costs
associated  with  professional  services  consisting  of financial  consultants,
attorneys  and public and media  relations and the increase in payroll costs due
to the addition of personnel.  The Company expects future  selling,  general and
administrative  expenses to increase in the  remainder of 1996 and beyond due to
the  increased  support  required  for  research  and  development   activities,
continuing  corporate  development  and  professional   services,   and  general
corporate activities.

           INTEREST  INCOME.  For the three  months  ended  September  30, 1996,
interest  income  increased to $856,000  compared to interest income of $106,000
for the three months ended  September  30,  1995.  Interest  income for the nine
months ended  September 30, 1996 increased to $1.57 million from $134,000 in the
same period of the prior year. The increases in interest  income result from the
investment of proceeds received from the Company's  secondary public offering in
April 1996, as well as the continued  interest income from the proceeds from the
Company's  initial public offering and the Pharmacia & Upjohn  investment in the
Company's Common Stock.

           INTEREST  EXPENSE.  Interest  expense  for  the  three  months  ended
September 30, 1996 decreased to $9,000  compared to interest  expense of $40,000
for the three  months  ended  September  30,  1995.  For the nine  months  ended
September 30, 1996,  interest expense  decreased to $27,000 from $139,000 in the
comparable  period of the prior year.  The decreases  result  primarily from the
conversion of the Company's convertible notes to Common Stock (approximately 79%
were  converted  in  December  1994,  18%  were  converted  during  1995 and the
remaining 3% have been converted during 1996).

           The Company does not believe that inflation has had a material impact
on its results of operations.

LIQUIDITY AND CAPITAL RESOURCES

           Since  inception   through   September  30,  1996,  the  Company  has
accumulated a deficit of approximately  $47.1 million and expects to continue to
incur  substantial and increasing  operating  losses for the next several years.
The Company has financed its  operations  primarily  through a secondary  public
offering in April  1996,  Pharmacia & Upjohn's  purchase  of Common  Stock,  its
initial public  offering and private  placements of common and preferred  stock,
and  private  placements  of  convertible  notes and  short  term  notes.  As of
September  30, 1996,  the Company had  received  net  proceeds  from the sale of
equity  securities and convertible  notes of  approximately  $110.7 million.  In
addition,  the  Company  has  financed a  substantial  portion of its  leasehold
improvements  and  certain  equipment  through  capital  lease  obligations,   a
leasehold  improvement loan and a bank line of credit. The Company has available
a $1.0 million bank line of credit which has a variable  rate of interest  based
on the bank's  lending rate (7.8% as of September  30,  1996),  which expires on
January 31, 1997, and is  collateralized  by the Company's  cash  balances.  The
credit  agreement  subjects  the  Company  to  certain  customary  restrictions,
including a prohibition on the payment of dividends.  The Company  presently has
no outstanding borrowings under the bank line of credit.

           In April 1996, the Company  completed a secondary  public offering of
1,500,000  shares of Common Stock which  provided net proceeds to the Company of
approximately  $65.4 million.  These proceeds are anticipated to be used to fund
preclinical and clinical  testing,  research and development and the balance for
general  corporate  activities.  Pending such uses, the Company has invested the
net proceeds in  short-term,  interest-bearing  obligations  which may primarily
consist   of  those   issued  by  the  U.S.   Government,   its   agencies   and
instrumentalities.

           In July  1996,  the  Company's  Board  of  Directors  authorized  the
purchase  of up to 600,000  shares of the  Company's  Common  Stock.  During the
quarter ended September 30, 1996, the Company repurchased 7,500 shares at a cost
of $250,000 under this repurchase program.

           In connection  with the licensing  agreement with Pharmacia & Upjohn,
the Company has  recorded as license  income for the  reimbursement  of clinical
costs of $614,000 in the third  quarter of 1996,  and $1.71 million for the nine
months ended  September  30, 1996.  The Company  anticipates  recording  license
income for the  reimbursement of clinical costs throughout the remainder of 1996
and beyond.

           For the first nine  months of 1996,  the  Company  required  cash for
operations of approximately  $12.6 million compared to $5.4 million for the same
period in 1995.  The increase in cash used in operations was primarily due to an
increase in operating  activities  associated  with the  continued  expansion of
preclinical  and clinical  testing,  the  increase in research  and  development
activities, the growth of research and development and support personnel and the
increase in general corporate activities. For the first nine months of 1996, the
Company received net cash from its financing  activities of approximately  $65.8
million as compared to $15.8  million for the same period in 1995.  The increase
results from the sale of Common Stock in the Company's secondary public offering
which closed in April 1996.

           The Company  invested a total of $1.3 million in property,  plant and
equipment  during the first nine months of 1996 as  compared to $503,000  during
the same period in 1995.  The Company  expects to purchase  property,  plant and
equipment  during the remainder of 1996 as the Company expands its  preclinical,
clinical and  research and  development  activities.  In June 1996,  the Company
entered  into an  agreement  for the  leasing of an  additional  facility  which
commenced in September  1996. The move to this facility will require  additional
expenditures  for the  construction  of the  laboratories  and office  space and
purchases of equipment.  Since  inception,  the Company has entered into capital
lease agreements for approximately  $184,000 of equipment,  consisting primarily
of laboratory equipment. The Company expects to continue to lease equipment from
time to time as needed.

           The Company's  capital  requirements will depend on numerous factors,
including the progress and magnitude of the Company's  research and  development
programs and  preclinical and clinical  testing,  the time involved in obtaining
regulatory approvals, the cost involved in filing and maintaining patent claims,
technological  advances,  competitor and market  conditions,  the ability of the
Company  to  establish  and  maintain  collaborative  arrangements,  the cost of
manufacturing  scale-up  and the cost  and  effectiveness  of  commercialization
activities and arrangements.

           The Company has raised funds in the past  through  public and private
placement  offerings..  The Company believes that these funds should satisfy its
capital requirements for the next few years. The Company may contemplate raising
funds  in  the  future  through  public  or  private  financings,  collaborative
arrangements  or from other  sources.  The success of such efforts in the future
will  depend  in  large  part  upon  continuing  developments  in the  Company's
preclinical  and  clinical  testing and the success of  photodynamic  therapy in
general.  The Company is also in discussion with other  companies  regarding the
potential   for   license   agreements,   equity   investments,    collaborative
arrangements,   or  development  or  other  funding  programs  in  exchange  for
marketing,  distribution  or other rights to products  developed by the Company.
However,  there can be no assurance that  discussions  with other companies will
result in any investments, collaborative arrangements, agreements or funding.

                           PART II. OTHER INFORMATION

ITEM 4.    SUBMISSION OF MATTER TO A VOTE OF SECURITY HOLDERS

On July 17,  1996,  the Company  held its Annual  Meeting of  Stockholders.  The
following individuals were elected to the Board of Directors:



                                                                Votes
                                     Votes For                 Withheld
                                     ---------                 --------


      Daniel R. Dorion, Ph.D         9,984,406                 40,775
      Michael D. Farney              9,984,406                 40,775
      Charles T. Foscue              9,979,454                 45,727
      Gary S. Kledzik, Ph.D.         9,984,406                 40,775
      David E. Mai.                  9,978,554                 46,627
      Donald K. McGhan.              9,983,338                 41,843
      Raul E. Perez, M.D.            9,983,728                 90,453


The following proposals were approved at the Company's Annual Meeting:
<TABLE>
<CAPTION>

                                                                                    Votes                       Broker
                                                                     Votes For     Against      Abstained      Non-Votes
                                                                ---------------- -----------   -----------   -------------
<S>                                                             <C>              <C>              <C>           <C>

1.    Proposal  to amend  Article  II,  Section  2 of the
      Company's  Bylaws  to increase the number of directors
      to no more than nine (9) and no less than five (5).             9,138,589     195,664     15,620         675,308

2.    Proposal to adopt the PDT, Inc. Stock Compensation Plan.        9,287,628     272,839     18,130         446,584

3.    Proposal  to  ratify  the  selection  of  the  Company's
      independent auditors.                                          10,009,438       9,723      6,020               0

</TABLE>
<PAGE>


ITEM 6.    EXHIBITS AND REPORTS ON FORM 8-K

                     (A)       Exhibits.
                               See Exhibit Index on page 14.

                     (B)       Reports on Form 8-K.
                               None.


<PAGE>







                                   SIGNATURES

           Pursuant to the requirements of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed in its behalf by the
undersigned thereunto duly authorized.


                                          PDT, INC.




Date:   November 12, 1996           By:   /s/ John M. Philpott
                                          --------------------
                                          John M. Philpott
                                          Chief Financial Officer and Controller
                                          (on behalf of the Company and as
                                          Principal Financial Officer and
                                          Principal Accounting Officer)



<PAGE>

<TABLE>
<CAPTION>


                                                       
                                                                                                             
                                                INDEX TO EXHIBITS
                                                                                                     Incorporating
Exhibit                                                                                              Reference
Number                                                Description                                    (if applicable)
- ------                                                -----------                                    ---------------
<S>     <C>                                                                                           <C>    

3.1      Certificate of Amendment of the Restated Certificate of Incorporation of the Registrant      [C][3.11]
         filed with the Delaware Secretary of  State on  July 24, 1995.
3.2      Restated Certificate of Incorporation of the Registrant filed with the Delaware Secretary    [B][3.1]
         of State on December 14, 1994.
3.3      Certificate of Amendment of the Certificate of Incorporation of the Registrant filed with    [A][3.2]
         the Delaware Secretary of State on March 17, 1994.
3.4      Certificate of Amendment of the Certificate of Incorporation of the Registrant filed with    [A][3.3]
         the Delaware Secretary of State on October 7, 1992.
3.5      Certificate of Amendment of the Certificate of Incorporation of the Registrant filed with    [A][3.4]
         the Delaware Secretary of State on November 21, 1991.
3.6      Certificate of Amendment of the Certificate of Incorporation of the Registrant filed with    [A][3.5]
         the Delaware Secretary of State on September 27, 1991.
3.7      Certificate of Amendment of the Certificate of Incorporation of the Registrant filed with    [A][3.6]
         the Delaware Secretary of State on December 20, 1989.
3.8      Certificate of Amendment of the Certificate of Incorporation of the Registrant filed with    [A][3.7]
         the Delaware Secretary of State on August 11, 1989.
3.9      Certificate of Amendment of the Certificate of Incorporation of the Registrant filed with    [A][3.8]
         the Delaware Secretary of State on July 13, 1989.
3.10     Certificate of Incorporation of the Registrant filed with the Delaware Secretary of State    [A][3.9]
         on June 16, 1989.
3.11     Amended and Restated Bylaws of the Registrant.
4.1      Specimen Certificate of Common Stock.                                                        [B][4.1]
4.2      Form of Convertible Promissory Note.                                                         [A][4.3]
4.3      Form of Indenture.                                                                           [A][4.4]
4.4      Special Registration Rights Undertaking.                                                     [A][4.5]
4.5      Undertaking Agreement dated August 31, 1994.                                                 [A][4.6]
4.6      Letter Agreement dated March 10, 1994.                                                       [A][4.7]
4.7      Form of $10,000,000 Common Stock and Warrants Offering Investment Agreement.                 [A][4.8]
10.1     PDT, Inc. Stock Compensation Plan.*                                                          [D]
10.2+    Ophthalmology Amendment to Development and License Agreement between Registrant and
         Pharmacia & Upjohn S.p.A. and Pharmacia & Upjohn AB.
10.3     Forms of Loan Program including Loan Program Agreement Employee, Loan Promissory Note and
         Loan Program Summary Description.
10.4     Form of Amendment No. 3 to 1989 Stock Option Agreement.*
11.1     Statement regarding computation of net loss per share.
27.1     Financial Data Schedule.
- -------------------
[A]   Incorporated by reference from the exhibit referred to in brackets contained in the
      Registrant's Registration Statement on Form S-1 (File No. 33-87138).
[B]   Incorporated by reference from the exhibit referred to in brackets contained in Amendment
      No. 2 to the Registrant's Registration Statement on Form S-1 (File No. 33-87138).
[C]   Incorporated  by reference  from the exhibit  referred to in brackets contained in the
      Registrant's Form 10-Q for the quarter ended June 30, 1995, as amended on Form 10-Q/A dated
      December 6, 1995 (File No.0-25544).
[D]   Incorporated by reference from the Registrant's 1996 Definitive Proxy Statement filed June 18, 1996.   
+     Filed  subject  to  confidential treatment.  Confidential  portions of this  exhibit have been 
      omitted (by redacting-out such material).
*     Management contract or compensatory plan or arrangement.



</TABLE>



<PAGE>

                                   Exhibi 3.11







                              AMENDED AND RESTATED
                                    BYLAWS OF

                                   PDT, INC.,

                             A DELAWARE CORPORATION


                                    ARTICLE I
                             SHAREHOLDERS' MEETINGS


Section 1. Place of Meetings.

     All meetings of the shareholders of this corporation  ("Corporation") shall
be held at the principal  executive  office of the  Corporation  in the State of
Delaware,  or such other place within or without the State as may be  designated
from time to time by the Board of Directors or as may be consented to in writing
by all of the persons entitled to vote thereat and not present at the meeting.

Section 2. Annual Meeting.

     The annual  meeting of the  shareholders  shall be held  within one hundred
fifty (150) days after the  closing of the  accounting  year,  at which time the
shareholders  shall elect a Board of Directors,  consider reports of the affairs
of the Corporation,  and transact such other business as may properly be brought
before the meeting.  In the event the annual meeting of shareholders is not held
within the time above specified, the Board of Directors shall cause a meeting in
lieu thereof to be held as soon  thereafter as is  convenient,  and any business
transacted  or election held at such meeting shall be as valid as if the meeting
had been held on the date above specified.

Section 3. Special Meetings.

     Special meetings of the shareholders,  for the purpose of taking any action
permitted to be taken by the shareholders under the Delaware General Corporation
Law and the  Certificate  of  Incorporation,  may be  called  at any time by the
Chairman of the Board, the President,  the Board of Directors,  or by any two or
more members thereof,  or by one or more shareholders  holding not less than ten
percent (10%) of the voting power of the Corporation.

Section 4. Notice of Meetings.

     Notice of  meetings,  annual or special,  shall be given in writing to each
shareholder  entitled  to vote at that  meeting by the  Secretary  or  Assistant
Secretary, or, if there be no such officers, by the Chairman of the Board or the
President,  or in the case of  neglect  or  refusal,  by any  person or  persons
entitled to call a meeting, not less than ten (10) nor more than sixty (60) days
before such meeting.

     Such written  notice shall be given either  personally or by other means of
written  communication,  addressed  to the  shareholder  at the  address  of the
shareholder  appearing  on  the  books  of  the  Corporation  or  given  by  the
shareholder to the Corporation for the purpose of notice;  or if no such address
appears or is given, at the place where the principal  office of the Corporation
is located or by publication at least once in a newspaper of general circulation
in the county in which the principal executive office is located.  The giving of
notice as provided by these  Bylaws may be omitted only to the extent and in the
manner expressly permitted by the Delaware General Corporation Law.

Section 5. Notice of Adjournment.

     When a meeting is adjourned for more than  forty-five (45) days or if after
the adjournment a new record date is fixed for the adjourned  meeting,  a notice
of the adjourned  meeting shall be given as in the case of an original  meeting.
Except as stated  above,  it shall not be  necessary  to give any  notice of the
adjourned  meeting,  other than by announcement of the time and place thereof at
the meeting at which such adjournment is taken, and the Corporation may transact
at the adjourned  meeting any business  which might have been  transacted at the
original meeting.

Section 6. Contents of Notice.

     Notice of any meeting of shareholders shall specify:

     a.   The place, the date and the time of the meeting;

     b.   Those  matters  which the  Board,  at the time of the  mailing  of the
          notice, intends to present for action by the shareholders;

     c.   If directors are to be elected,  the names of nominees intended at the
          time of the notice to be presented by management for election;

     d.   The general  nature of any proposal to take action with respect to the
          approval of (i) a contract  or other  transaction  with an  interested
          director, (ii) an amendment of the Certificate of Incorporation, (iii)
          the  reorganization  of the  Corporation  within  the  meaning  of the
          Delaware General  Corporation  Law, (iv) the voluntary  dissolution of
          the  Corporation,  or (v) a distribution in dissolution  other than in
          accordance with the rights of any outstanding preferred shares; and

     e.   Such other matters, if any, as may be expressly required by statute.

Section 7. Consent to Shareholder's Meeting.

     The  transactions  of any  meeting  of  shareholders,  however  called  and
noticed,  shall be valid as those had at a meeting duly held after  regular call
and notice,  if a quorum is present either in person or by proxy, and if, either
before or after the meeting,  each of the persons  entitled to vote, not present
in  person or by proxy,  signs a  written  waiver of notice or a consent  to the
holding of the meeting or an approval  of the minutes of the  meeting.  All such
waivers,  consents and approvals  shall be filed with the  corporate  records or
made a part of the  minutes of the  meeting.  A waiver of notice or a consent to
the  holding of any  meeting  of  shareholders  need not  specify  the  business
transacted at or the purpose of any regular or special  meeting,  other than any
proposal approved or to be approved at such meeting, the general nature of which
was  required by Section  6.d. of these Bylaws to be stated in the notice of the
meeting.

Section 8. Action Without a Meeting.

     Unless otherwise  provided in the Certificate of Incorporation,  any action
which may be taken at any annual or special meeting of the  shareholders,  other
than the election of directors, may be taken without a meeting and without prior
notice,  if a consent in  writing,  setting  forth the action so taken  shall be
signed by the  holders of  outstanding  shares  having not less than the minimum
number of votes necessary to authorize or take such action at a meeting at which
all shareholders entitled to vote were present and voted.

     Unless  the  consents  of all  shareholders  entitled  to  vote  have  been
solicited  in  writing,  prompt  notice  shall  be given  of the  taking  of any
corporate  action  approved  by  shareholders  without  a  meeting  by less than
unanimous  written consent to those  shareholders  entitled to vote who have not
consented  in writing,  and, as to any action with  respect to (i) a contract or
other transaction with an interested  director,  (ii) the indemnification of any
present or former agent of the Corporation  within the meaning of Section 145 of
the  Delaware  General  Corporation  Law,  (iii) any  reorganization  within the
meaning of the  Delaware  General  Corporation  Law, or (iv) a  distribution  in
dissolution  other  than  in  accordance  with  the  rights  of any  outstanding
preferred  shares,  such notice shall be given at least ten (10) days before the
consummation of such action.

     A director  may be elected at any time to fill a vacancy  not filled by the
Board by the written  consent of persons  holding a majority of the  outstanding
shares  entitled to vote for the election of directors,  and any required notice
of any such election  shall promptly be given as provided  above.  Directors may
not otherwise be elected without a meeting unless a consent in writing,  setting
forth the action so taken, is signed by all of the persons who would be entitled
to vote for the election of directors.

Section 9. Quorum; Adjournment.

     The holders of a majority of the shares  entitled to vote,  represented  in
person or by proxy,  shall be  required  and  shall  constitute  a quorum at all
meetings  of the  shareholders  for  the  transaction  of  business,  except  as
otherwise provided by the Certificate of Incorporation. The shareholders present
at a duly called or held meeting at which a quorum is present may continue to do
business until adjournment notwithstanding the withdrawal of enough shareholders
to leave less than a quorum,  if any action  taken (other than  adjournment)  is
approved by at least a majority of the shares  required to  constitute a quorum.
If a  quorum  shall  not  be  present  or  represented  at  any  meeting  of the
shareholders, the meeting may be adjourned from time to time by majority vote of
the  shares  entitled  to vote at the  meeting  who are  present  in  person  or
represented  by proxy,  until the  requisite  number of voting  shares  shall be
present.

Section 10. Voting Rights; Cumulative Voting.

     Subject to the  provisions of Sections 212 through 218,  inclusive,  of the
Delaware General Corporation Law, only persons in whose names shares entitled to
vote stand on the stock records of the  Corporation  on the record date shall be
entitled to vote at meetings of the shareholders.  Every shareholder entitled to
vote shall be entitled to one vote for each of such shares,  and the affirmative
vote of a majority of the shares represented at the meeting and entitled to vote
on any matter shall be the act of the shareholders, unless the vote of a greater
number or voting by classes is required by the Delaware General  Corporation Law
or by the Certificate of Incorporation.

     Every shareholder  entitled to vote at any election of directors shall have
the right to  cumulate  his votes to the extent and in the  manner  provided  by
Section 214 of the Delaware General Corporation Law.

Section ll. Proxies.

     Every shareholder  entitled to vote or to execute consents may do so either
in person or by written proxy executed in accordance  with the provisions of the
Delaware  General  Corporation  Law and filed with the  Secretary  or  Assistant
Secretary of the Corporation.

Section 12. Inspectors of Election.

     Before any meeting of shareholders,  the Board of Directors may appoint any
persons  other than nominees for office to act as Inspectors of Election at such
meeting or any adjournment  thereof. If no Inspectors of Election are appointed,
or if an  appointment is vacated by an Inspector who fails to appear or fails or
refuses to act,  the Chairman of any such meeting may, and on the request of any
shareholder  or his proxy shall,  make such  appointment or fill such vacancy at
the meeting.

                                   ARTICLE II
                                    DIRECTORS

Section 1. Powers.

     Subject to the limitations of the Certificate of Incorporation, the Bylaws,
and of the Delaware  General  Corporation  Law as to action to be  authorized or
approved by the  shareholders,  all  corporate  powers  shall be exercised by or
under the authority of, and the business and affairs of the Corporation shall be
controlled by, the Board of Directors.

Section 2. Number and Qualification of Directors.

     The  authorized  number of directors of this  Corporation  will be not less
than  five nor more than nine (9),  and the exact  number of  directors  will be
seven (7) until  changed,  within the limits  specified  above,  by a resolution
amending  such exact  number,  duly  adopted by the Board of Directors or by the
stockholders. Subject to the provisions of the Certificate of Incorporation, the
minimum and maximum number of directors may be changed, or a definite number may
be fixed without provision for an indefinite number, by a duly adopted amendment
to the  Certificate  of  Incorporation  or by an  amendment  to this  ByLaw duly
adopted  by the  vote  or  written  consent  of  holders  of a  majority  of the
outstanding shares entitled to vote;  provided,  however,  that no decrease will
shorten the term of any incumbent  director unless such director is specifically
removed  pursuant to Section 5 of this Article II of these ByLaws at the time of
such  decrease.  (Section 2 was  amended in its  entirety  at the July 17,  1996
Annual Meeting of Stockholders.)

Section 3. Election of Directors.

     The  directors  shall be  elected  by ballot at the  annual  meeting of the
shareholders  to hold  office  until the next  annual  meeting  and until  their
successors  are  elected  and  qualified.  Their  term  of  office  shall  begin
immediately after election.

Section 4. Vacancies.

     A vacancy in the Board of Directors shall be deemed to exist in the case of
the  death,  resignation  or  removal of any  director,  if a director  has been
declared  of unsound  mind by order of Court or  convicted  of a felony,  if the
authorized number of directors is increased,  or if the shareholders shall fail,
either  at a  meeting  at  which an  increase  in the  number  of  directors  is
authorized,  or at an  adjournment  thereof,  or at any other time, to elect the
full number of authorized directors.

     Vacancies in the Board of  Directors,  except for a vacancy  created by the
removal of a director,  may be filled by a majority of the remaining  directors,
and each director so elected shall hold office until his successor is elected at
an annual or  special  meeting  of the  shareholders.  A vacancy  created by the
removal of a director may be filled only by a vote of the majority of the shares
entitled to vote at a duly held meeting of the  shareholders,  or by the written
consent of the holders of a majority of the outstanding shares.

     The  shareholders may at any time elect a director or directors to fill any
vacancies not filled by the directors.

     If any director  tenders his  resignation to the Board of Directors to take
effect at a future time, the Board or the  shareholders  shall have the power to
elect a successor  to take office at such time as the  resignation  shall become
effective.

     No reduction of the authorized number of directors shall have the effect of
removing any director prior to the expiration of his term of office.

Section 5. Removal of Directors.

     The entire Board of Directors,  or any individual director,  may be removed
from office in the manner provided by the Delaware General Corporation Law.

Section 6. Place of Meeting.

     Meetings of the Board of Directors shall be held at the principal executive
office of the  Corporation,  or as designated from time to time by resolution of
the Board of  Directors  or written  consent of all of the members of the Board.
Any meeting shall be valid wherever held if held with the written consent of all
members of the Board of Directors,  given either before or after the meeting and
filed with the Secretary or Assistant Secretary of the Corporation.

Section 7. Annual Meeting.

     A regular  annual  meeting of the Board of Directors  shall be held without
notice at the place of the annual meeting of shareholders  immediately following
the adjournment thereof, for the purpose of organization,  election of officers,
and the  transaction  of such other  business  as may  properly  come before the
meeting.

Section 8. Other Regular Meetings.

     Other regular  meetings of the Board of Directors shall be held on the last
Thursday of each calendar quarter.

Section 9. Special Meetings; Notices.

     Written notice of the time and place of special meetings shall be delivered
or  communicated  personally to each  director by  telephone,  or by telecopy or
mail,  charges prepaid,  addressed to him at his address as it is shown upon the
records of the Corporation, or if such address is not readily ascertainable,  at
the place in which the meetings of the  directors  are  regularly  held. If such
notice is mailed or telecopied,  it shall be deposited in the United States mail
or delivered at least forty-eight (48) hours prior to the time of the holding of
the meeting.  In case such notice is delivered  personally or by  telephone,  it
shall be so  delivered  at least  twenty-four  (24)  hours  prior to the time of
holding the meeting.  Such mailing,  telecopying  or delivery,  personally or by
telephone,  as above provided  shall be due,  legal and personal  notice to such
director.

Section 10. Waiver of Notice.

     The  transactions of any meeting of the Board of Directors,  however called
and noticed or wherever held, are as valid as though had at a meeting  regularly
called and  noticed if all the  directors  are present and sign a consent to the
holding of the  meeting on the records of the  meeting,  or if a majority of the
directors are present and each of those not present,  either before or after the
meeting,  signs a written waiver of notice, or a consent to holding the meeting,
or an approval of the minutes of the meeting.  All such  waivers,  consents,  or
approvals  shall  be  filed  with the  corporate  records  or made a part of the
minutes of the meeting.

Section ll. Action of Directors Without Meeting.

     Any action  required or permitted to be taken by the Board of Directors may
be taken without a meeting,  if all members of the Board shall  individually  or
collectively consent in writing to such action. Such written consent or consents
shall be filed with the minutes of the proceedings of the Board,  and shall have
the same force and effect as a unanimous vote of the directors.

Section 12. Action at a Meeting; Quorum.

     A majority of the  authorized  number of  directors  shall be  necessary to
constitute  a quorum  for the  transaction  of  business,  and the  action  of a
majority of the  directors  present at a meeting  duly held at which a quorum is
present,  when duly  assembled,  is valid as a  corporate  act  unless a greater
number is required by the  Certificate of  Incorporation,  these Bylaws,  or the
Delaware General Corporation Law. Directors may participate in a meeting through
the use of conference telephone or similar  communications  equipment as long as
all  members  participating  in the  meeting  can  hear  one  another,  and such
participation shall constitute the presence in person at the meeting.

Section 13. Adjournment.

     A majority of the directors  present,  whether or not a quorum, may adjourn
from time to time by fixing a new time and  place  prior to taking  adjournment,
but if any meeting is adjourned for more than twenty-four (24) hours,  notice of
any adjournment to another time or place shall be given prior to the time of the
adjourned  meeting to any directors not present at the time the  adjournment was
taken.


Section 14. Committees.

     The Board of  Directors  may, by  resolutions  adopted by a majority of the
authorized number of directors,  establish one or more committees,  including an
Executive Committee,  each consisting of two or more directors,  to serve at the
pleasure of the Board. The Board of Directors may delegate to any such committee
any of the powers and  authority  of the Board of  Directors in the business and
affairs of the  Corporation,  except those powers  specifically  reserved to the
Board of Directors  by the  provisions  of Section 141 of the  Delaware  General
Corporation  Law. The Board shall  prescribe the manner in which the proceedings
of the Executive  Committee or any other Committee  shall be conducted,  and may
designate  one or more  alternate  directors  to replace  any  absent  committee
members at any meeting of the Committee.


                                   ARTICLE III
                                    OFFICERS

Section l. Officers.

     The officers of the  Corporation  shall be elected by and shall hold office
at the  pleasure  of the Board of  Directors.  These  officers  shall  include a
President,  one or more  Vice  Presidents,  a  Secretary  and a Chief  Financial
Officer, and may include a Chairman of the Board of Directors.

Section 2. Election.

     After their  election,  the Board of  Directors  shall meet and organize by
electing a  President,  one or more Vice  Presidents,  a  Secretary  and a Chief
Financial  Officer,  who may be,  but  need  not be,  members  of the  Board  of
Directors, and such additional officers provided by these Bylaws as the Board of
Directors shall determine to be appropriate. Any two or more offices may be held
by the same person.

Section 3. Compensation and Tenure of Office.

     The  compensation  and  tenure  of  office  of all of the  officers  of the
Corporation shall be fixed by the Board of Directors.

Section 4. Removal and Resignation.

     Any officer may be removed,  either with or without cause, by a majority of
the  directors at the time in office,  at any regular or special  meeting of the
Board, or except in the case of an officer chosen by the Board of Directors,  by
any  officer  upon whom such power of removal may be  conferred  by the Board of
Directors,  subject in each case, however, to any rights of an officer under any
contract of employment.

     Any officer may resign at any time by giving written notice to the Board of
Directors or to the President,  or to the Secretary or an Assistant Secretary of
the Corporation  without  prejudice,  however,  to any rights of the Corporation
under any contract to which such officer is a party.

     Any such  resignation  shall  take  effect at the date of  receipt  of such
notice or at any later  time  specified  in the  notice;  and  unless  otherwise
specified therein,  the acceptance of such resignation shall not be necessary to
make it effective.

Section 5. Vacancies.

     Any vacancy in an office occurring because of death, resignation,  removal,
disqualification  or any other cause may be filled by the Board of  Directors at
any regular or special  meeting of the Board, or in such manner as may otherwise
be prescribed in the Bylaws for appointment to such office.

Section 6. Chairman of the Board.

     The Chairman of the Board, if there be one, shall, when present, preside at
all meetings of the shareholders  and of the Board of Directors,  and shall have
such other  powers and  duties as from time to time shall be  prescribed  by the
Board of Directors.

Section 7. President.

     The President shall be the general manager of the Corporation  and, subject
to the control of the Board of Directors,  shall be chief  executive  officer of
the Corporation and shall have general supervision, direction and control of the
business and affairs of the  Corporation.  If the Corporation has no Chairman of
the Board,  the President  shall also have the duties  prescribed  above for the
Chairman of the Board.

Section 8. Vice Presidents.

     In the absence or the disability of the President, the Vice Presidents,  in
order of their rank as fixed by the Board of  Directors,  or if not ranked,  the
Vice President designated by the directors, or if no such designation is made by
the Board of Directors,  the Vice President  designated by the President,  shall
perform the duties and exercise the powers of the  President,  and shall perform
such other  duties and have such other  powers as the Board of  Directors  shall
prescribe.

Section 9. Secretary.

     The  Secretary  shall keep,  or cause to be kept,  a book of Minutes at the
principal  executive  office or such other place as the Board of  Directors  may
order, of all the proceedings of its shareholders and the Board of Directors and
Committees of the Board, with the time and place of holding of meetings, whether
regular or special,  and if special,  how authorized,  the notice thereof given,
the names of those present at directors' meetings,  the number of shares present
or represented at shareholders' meetings, and the proceedings of these meetings.

     The Secretary  shall keep, or cause to be kept, at the principal  executive
office or at the office of the Corporation's transfer agent, a share register or
a duplicate  share  register,  showing the names of the  shareholders  and their
addresses, the number and classes of shares held by each, the number and date of
certificates  issued for the same,  and the number and date of  cancellation  of
every certificate surrendered for cancellation.

Section 10. Assistant Secretary.

     The Assistant  Secretary,  if there is one, shall have all the same rights,
duties,  powers and  privileges  as the  Secretary  and may act in his place and
stead whenever necessary or desirable.

Section ll. Chief Financial Officer.

     The Chief  Financial  Officer shall keep and maintain,  or cause to be kept
and  maintained,  adequate and correct  accounts of the  properties and business
transactions of the Corporation,  including accounts of its assets, liabilities,
receipts,  disbursements,  gains, losses, capital, surplus and shares. The books
of account shall at all reasonable times be open to inspection by any director.

     The Chief Financial Officer shall deposit all moneys and other valuables in
the name and to the credit of the Corporation  with such  depositories as may be
designated  by the  Board of  Directors.  He  shall  disburse  the  funds of the
Corporation  as may be ordered by the Board of  Directors,  shall  render to the
President  and  directors,  whenever  they so  request,  an  account  of all his
transactions  as Chief Financial  Officer and of the financial  condition of the
Corporation,  and shall have such other  powers and perform such other duties as
may be prescribed by the Board of Directors or the Bylaws.

Section 12. Subordinate Officers.

     Subordinate Officers,  including but not limited to, Assistant Secretaries,
Treasurers  and  Assistant  Treasurers,  or  agents,  as  the  business  of  the
Corporation  may  require,  may from time to time be  appointed  by the Board of
Directors,  the President,  or by any officer empowered to do so by the Board of
Directors,  and shall have such  authority  and shall perform such duties as are
provided  in the  Bylaws  or as the  Board of  Directors  may from  time to time
determine.

                                   ARTICLE IV
                  CORPORATE RECORDS, INSPECTION, VOTING SHARES
                             IN NAME OF CORPORATION

Section l. Records.

     The  Corporation  shall maintain  adequate and correct books and records of
account of its business and properties.  All of such accounts, books and records
shall be kept at its principal business office, or at such other location as may
be fixed by the Board of Directors from time to time.

Section 2. Inspection.

     The  accounting  books and records and  Minutes of the  proceedings  of the
shareholders  and the Board of  Directors  and its  Committees  shall be open to
inspection by the  shareholders  from time to time and in the manner provided in
Section 220 of the Delaware  General  Corporation  Law, and every director shall
have the right to  inspect  and copy all books,  records  and  documents  of the
Corporation,  and to inspect its  properties,  in the manner provided by Section
220 of the Delaware General Corporation Law.

Section 3. Voting Shares in Name of Corporation.

     Shares standing in the name of this Corporation may be voted or represented
and all  rights  incident  to those  shares  may be  exercised  on behalf of the
Corporation  by the  President,  or if he is unable or refuses to act, by a Vice
President or by such other person as the Board of Directors may determine.


                                    ARTICLE V
                       CERTIFICATES AND TRANSFER OF SHARES

Section l. Certificates for Shares.

     Every  holder of  shares in the  Corporation  shall be  entitled  to have a
certificate,  in such form and device as the Board of Directors  may  designate,
certifying the number of shares and the classes or series of shares owned by the
shareholder,  and  containing a statement  setting forth the office or agency of
the Corporation from which the shareholder may obtain,  upon request and without
charge,  a copy of the  statement of any rights,  preferences,  privileges,  and
restrictions  granted  to or  imposed  upon  each  class  or  series  of  shares
authorized  to be issued  and upon the  holders of those  shares,  and any other
legend or statement as may be required  under the Delaware  General  Corporation
Law and federal and state corporate securities laws.

     Every certificate for shares shall be signed in the name of the Corporation
by the President or Vice President and the Secretary or an Assistant  Secretary.
Any signature on the certificate may be by facsimile, provided that at least one
signature,  which  may but need not be that of the  Corporation's  registrar  or
transfer agent, if any, shall be manually signed.

Section 2. Transfer on the Books.

     Upon  surrender to the Secretary or Assistant  Secretary or to the transfer
agent  of  the  Corporation  of  a  certificate  for  shares  duly  endorsed  or
accompanied  by proper  evidence  of  succession,  assignment  or  authority  to
transfer,  it shall be the duty of the Corporation to issue a new certificate to
the  person  entitled  thereto,  cancel  the  old  certificate  and  record  the
transaction upon its books.

Section 3. Lost or Destroyed Certificates.

     A new certificate  may be issued without the surrender and  cancellation of
an old certificate that is lost,  apparently destroyed or wrongfully taken when:
(a)  the  request  for the  issuance  of a new  certificate  is  made  within  a
reasonable  time after the owner of the old  certificate has notice of its loss,
destruction or theft; and (b) such request is received by the Corporation  prior
to its receipt of notice that the old  certificate  has been  acquired by a bona
fide purchaser; and (c) the owner of the old certificate gives an indemnity bond
or other  adequate  security  sufficient in the judgment of the  Corporation  to
indemnify it against any claim, expense or liability resulting from the issuance
of a new  certificate.  In the event of the issuance of a new  certificate,  the
rights and liabilities of the Corporation, and of the holders of the old and new
certificates,  shall be  governed  by the  provisions  of the  Delaware  General
Corporation Law.

Section 4. Transfer Agents and Registrars.

     The Board of Directors may appoint one or more transfer  agents or transfer
clerks,  and one or more  registrars,  which shall be banks or trust  companies,
either domestic or foreign,  at such times and places as the requirements of the
Corporation may necessitate and the Board of Directors may designate.

Section 5. Record Date.

     The Board of Directors  may fix, in advance,  a record date for the purpose
of determining  shareholders entitled to notice of and to vote at any meeting of
shareholders,  to consent to corporate  action in writing without a meeting,  to
receive any report,  to receive any dividend or other  distribution or allotment
of any right or to exercise  rights with  respect to any change,  conversion  or
exchange  of shares.  The record date so fixed shall not be more than sixty (60)
days prior to any event for the purpose for which it is fixed,  and shall not be
less than ten (10) days prior to the date of any meeting of the shareholders. If
no such  record  date is fixed by the Board of  Directors,  then the record date
shall be that date prescribed by Section 213 of the Delaware General Corporation
Law.

                                   ARTICLE VI
                                 CORPORATE SEAL

     The  corporate  seal shall be  circular in form,  and shall have  inscribed
thereon  the name of the  Corporation,  the date of its  incorporation,  and the
words "INCORPORATED DELAWARE.


                                   ARTICLE VII
                                   AMENDMENTS

Section l. By Shareholders.

     The Bylaws may be repealed or amended, or new Bylaws may be adopted, by the
affirmative vote of a majority of the outstanding  shares entitled to vote or by
the written  consent of  shareholders  entitled to vote such  shares,  except as
otherwise provided by the Delaware General Corporation Law or by the Certificate
of Incorporation.

Section 2. By Directors.

     Subject  to the right of  shareholders  as  provided  in  Section l of this
Article VII to adopt,  amend or repeal Bylaws, the Board of Directors may adopt,
amend or repeal Bylaws;  provided,  however, that no Bylaw or amendment changing
the number of directors of the  Corporation  shall be adopted  other than in the
manner provided by Section 2 of Article II of these Bylaws.

Section 3. Records of Amendments.

     Any  amendment  or new  Bylaw  adopted  by the  shareholders  or  Board  of
Directors shall be copied in the  appropriate  place in the Minute book with the
original  Bylaws,  and the repeal of any Bylaw shall be entered on the  original
Bylaws together with the date and manner of such repeal.  The original or a copy
of the Bylaws as amended to date shall be open to inspection by the shareholders
at the Corporation's  principal  executive office at all reasonable times during
office hours.

                                  ARTICLE VIII
                             WAIVER OF ANNUAL REPORT

     The  requirement  that  this  Corporation  send  an  annual  report  to its
shareholders is hereby expressly waived.


                                   ARTICLE IX
               INDEMNIFICATION OF OFFICERS, DIRECTORS, AND AGENTS

Section 1. Definitions.

     For the purposes of this Article IX the following definitions shall apply:

     a.   "Agent"  means  any  person  who  (a) is or was a  director,  officer,
          employee or other agent of the  Corporation,  or (b) is or was serving
          at the request of the Corporation as a director,  officer, employee or
          agent of another foreign or domestic corporation, joint venture, trust
          or other enterprise, or (c) was a director, officer, employee or agent
          of  a  foreign  or  domestic   corporation  which  was  a  predecessor
          corporation of the Corporation or of another enterprise at the request
          of such predecessor corporation.

     b.   "Proceeding"  means any  threatened,  pending or  completed  action or
          proceeding, whether civil, criminal, administrative or investigative.

     c.   "Expenses"  includes  without  limitation   attorneys'  fees  and  any
          expenses of establishing a right to indemnification under Section 5 of
          this Article IX below.
     d.   "Independent  Legal Counsel" means an attorney  mutually  agreeable to
          the  Corporation  and the  agent  seeking  indemnification,  with such
          attorney  to be  designated  within ten (10) days after  notice by one
          party to the other. If the Corporation and the agent seeking indemnity
          cannot agree upon the selection of such attorney  within such ten (10)
          day period,  an attorney  shall be  selected by the  Corporation  from
          among  five  (5)  attorneys  designated  in a  writing  by  the  agent
          delivered to the Corporation within five (5) days after the end of the
          ten  (10)  day  period;  provided,  however,  that  the  attorneys  so
          designated  have a minimum of ten (10) years  experience  in corporate
          law, and are each full partners (or the equivalent) in a law firm with
          at least five (5) attorneys.  If the  Corporation and the agent cannot
          agree upon the  selection of the  attorney,  and if the agent fails to
          designate his selection of five (5) attorneys  within the five (5) day
          period, the Corporation alone shall choose the attorney.

Section 2. Proceedings Other than By or In the Right of the Corporation.

     The  Corporation  shall  indemnify  any  person who was or is a party or is
threatened to be made a party to any  proceeding  (other than an action by or in
the right of the  Corporation  to procure a judgment  in its favor) by reason of
the  fact  that  such  person  is or was an  agent  of the  Corporation  against
expenses,   judgments,   fines,  settlements  and  other  amounts  actually  and
reasonably  incurred in connection  with such proceeding if such person acted in
good faith and in a manner  such  person  reasonably  believed to be in the best
interest of the Corporation  and, in the case of a criminal  proceeding,  had no
reasonable  cause to believe  the  conduct  of such  person  was  unlawful.  The
termination of any proceeding by judgment, order, settlement, conviction or upon
a plea of nolo  contendere  or its  equivalent  shall not,  of itself,  create a
presumption  that the person did not act in good faith and in a manner which the
person  reasonably  believed to be in the best  interests of the  Corporation or
that the person had  reasonable  cause to believe that the person's  conduct was
unlawful.

Section 3. Proceedings By or In the Right of the Corporation.

     The  Corporation  shall  indemnify  any  person who was or is a party or is
threatened to be made a party to any threatened,  pending or completed action by
or in the right of the  Corporation to procure a judgment in its favor by reason
of the fact that  such  person  is or was an agent of the  Corporation,  against
expenses actually and reasonably  incurred by such person in connection with the
defense or  settlement  of such action if such person acted in good faith,  in a
manner  such  person  reasonably  believed  to be in the  best  interest  of the
Corporation and its shareholders.

Section 4. Determination of Right to Indemnification.

     To the extent that a person who is or was an agent of the  Corporation  has
been  successful  on the  merits in  defense of any  proceeding  referred  to in
Section 2 or 3 of this Article IX above or in the defense of any claim, issue or
matter therein,  such person shall be indemnified  against expenses actually and
reasonably incurred by such person in connection therewith.

     Except as  provided in the first  paragraph  of this  Section 4 above,  any
indemnification  under  Section 2 or 3 of this Article IX above shall be made by
the  Corporation  only if authorized in the specific case,  upon a determination
that  indemnification  of the agent is proper in the  circumstances  because the
agent has met the applicable  standard of conduct set forth in Section 2 or 3 of
this Article IX above, by any of the following:  (a) a majority vote of a quorum
consisting of directors who are not parties to such action or proceeding; (b) if
such a quorum of directors is not obtainable,  by independent legal counsel in a
written  opinion;  (c) approval or  ratification  by the  affirmative  vote of a
majority of the shares  represented and voting at a duly held meeting at which a
quorum is present (which shares voting  affirmatively also constitute at least a
majority of the required quorum);  (d) written consent of the shareholders under
Section 228 of the Delaware General Corporation Law; (e) the affirmative vote or
written consent of such greater proportion  (including all) of the shares of any
class or series as may be provided in the Certificate of Incorporation or in the
Delaware General  Corporation Law, for all or any specified  shareholder action;
or (f) the court in which such  proceeding  is or was pending  upon  application
made by the  Corporation or the agent or the attorney or other person  rendering
service in connection with the defense,  whether or not such  application by the
agent, attorney or other person is opposed by the Corporation.

     The shares owned by the person to be  indemnified  shall not be entitled to
vote on any  written  consent  or  affirmative  vote  set  forth  in the  second
paragraph of Section 4 of this Article IX above.

Section 5. Indemnity for Expenses of Establishing Right to Indemnification.

     To the extent that a person who is or was an agent of the  Corporation  has
been  successful  on the  merits in  defense of any  proceeding  referred  to in
Section 2 or 3 of this  Article IX above,  or in defense of any claim,  issue or
matter  therein,  such  person  shall also be  indemnified  against  expenses of
establishing a right to indemnification actually and reasonably incurred by such
person in connection therewith.

     If   authorized  in  the  specific   case,   upon  a   determination   that
indemnification  of such  person  is proper in the  circumstances  because  such
person has met the applicable standard of conduct set forth in Section 2 or 3 of
this Article IX above, by any of the following:  (a) approval or ratification by
the  affirmative  vote of a majority of the shares  represented  and voting at a
duly  held  meeting  at  which  a  quorum  is  present   (which   shares  voting
affirmatively  also constitute at least a majority of the required quorum);  (b)
written consent of the  shareholders  under Section 228 of the Delaware  General
Corporation  Law, or (c) the affirmative vote or written consent of such greater
proportion  (including  all) of the  shares  of any  class or  series  as may be
provided  in  the  Certificate  of  Incorporation  or in  the  Delaware  General
Corporation Law, for all or any specified  shareholder action; such person shall
also  be   indemnified   against  any  expenses  of   establishing  a  right  to
indemnification actually and reasonably incurred therewith.

     The shares owned by the person to be  indemnified  shall not be entitled to
vote on any  written  consent  or  affirmative  vote  set  forth  in the  second
paragraph  of Section 5 of this  Article  IX above.  

Section  6.  Procedure  for Indemnification.

     Any  indemnification  under Section 2, 3, or 5 of this Article IX above, or
advance under Section 7 of this Article IX below, shall be made promptly, and in
any event within  sixty (60) days,  upon the written  request of the agent.  The
right to  indemnification  or  advances  as granted by this  Article IX shall be
enforceable  by the  agent  in  any  court  of  competent  jurisdiction,  if the
Corporation denies such request in whole or in part or if no disposition thereof
is made  within  sixty (60) days.  It shall be a defense to any such action that
the agent has not met the standard of conduct set forth in Section 2, 3, or 5 of
this  Article IX above,  or  regarding  a claim for  advances  the agent has not
delivered the required undertaking under Section 7 of this Article IX below, but
the burden of proving the defense is on the Corporation.

Section 7. Advances.

     Expenses  incurred in  defending  any  proceeding  shall be advanced by the
Corporation  prior to the final  disposition of such  proceeding upon receipt of
any undertaking by or on behalf of the person claiming a right to be indemnified
under this Article IX to repay such amount if it shall be determined  ultimately
that the agent is not entitled to be  indemnified  as authorized in this Article
IX.

Section 8. Other Rights and Continuation of Rights to Indemnification.

     The  indemnification  provided  by this  Article  IX  shall  not be  deemed
exclusive  of any other  rights to which those  seeking  indemnification  may be
entitled under any bylaw,  agreement,  approval of shareholders or disinterested
directors  or  otherwise,  both as to action in an official  capacity  and as to
action in any other  capacity  while  holding  such  office,  to the extent such
additional  rights to  indemnification  are  authorized  in the  Certificate  of
Incorporation.  The rights to indemnity  hereunder shall continue as to a person
who has ceased to be a director,  officer,  employee or agent and shall inure to
the benefit of the heirs,  executors,  and administrators of the person. Nothing
contained in this Article IX shall affect any right to  indemnification to which
persons  other than such  directors  and officers may be entitled by contract or
otherwise.

Section 9. Insurance.

     This Corporation may purchase and maintain insurance on behalf of any agent
of the  Corporation  against any liability  asserted or incurred by the agent in
such  capacity or arising out of the agent's  status as such  whether or not the
Corporation  would have the power to indemnify the agent against such  liability
under the provisions of this Article IX. The fact that the Corporation  owns all
or a portion of the shares of the company  issuing a policy of  insurance  shall
not render this Section 9 inapplicable if either of the following conditions are
satisfied:  (a) if authorized in the  Certificate of  Incorporation,  any policy
issued is  limited  to the  extent not in  conflict  with the  Delaware  General
Corporation  Law, or (b) the company issuing the insurance  policy is organized,
licensed,  and operated in a manner that complies  with the  insurance  laws and
regulations applicable to its jurisdiction of organization,  the company issuing
the policy  provides  procedures for  processing  claims that do not permit that
company to be subject to the direct  control of the  Corporation  that purchased
that  policy,  and the policy  issued  provides  for some manner of risk sharing
between  the  issuer  and  purchaser  or the  policy,  on  one  hand,  and  some
unaffiliated  person or  persons,  on the  other,  such as by  providing  that a
portion  of the  coverage  furnished  will be  obtained  from some  unaffiliated
insurer or reinsurer.

Section 10. Savings Clause.

     If this Article IX or any portion hereof shall be invalidated on any ground
by any court of competent jurisdiction,  then the Corporation shall nevertheless
indemnify  each person as to any expenses,  judgments,  fines,  settlements  and
other amounts incurred by such person in connection with any proceeding,  to the
fullest extent permissible under applicable law.

Section 11. Subsequent Amendment.

     If the Delaware  General  Corporation  Law or any other  applicable  law is
amended after approval by the  shareholders of this Article IX to further expand
the  indemnification  permitted  to  directors,   officers  and  agents  of  the
Corporation,  then the  Corporation  shall  indemnify such person to the fullest
extent  permissible  under  the  Delaware  General   Corporation  Law  or  other
applicable law, as so amended.

Section 12. Contract.

     The rights to indemnification  conferred in this Article shall be deemed to
be a  contract  between  the  Corporation  and each  person  who  serves  in the
capacities  described  above at any time  while this  Article is in effect.  Any
repeal or  modification of this Article shall not in any way diminish any rights
to indemnification of such person or the obligations of the Corporation  arising
hereunder.

Section 13. Indemnity Agreements.

     The Corporation may from time to time enter into indemnity  agreements with
the persons who are members of its Board of Directors  and with such officers or
other  agents of the  Corporation  as the Board may  designate,  such  indemnity
agreements to provide in substance  that the  Corporation  will  indemnify  such
persons to the fullest  extent  permitted by the  provisions of this Articles IX
and the Certificate of Incorporation.



<PAGE>


                                  Exhibit 10.2
Amendment 10 July 96



July 10, 1996

     Re:   Development   and  License   Agreement   between   Pharmacia   S.p.A.
     ("Pharmacia") and PDT, Inc. ("PDTI") dated July 1st, 1995, amended July 25,
     1995, September 11, 1995, and March 20, 1996 ("License Agreement")

Pharmacia and PDTI have entered into the License  Agreement  with respect to the
fields of Oncology,  Urology and Dermatology,  and now wish to amend the License
Agreement with respect to the field of Ophthalmology.

Pharmacia  and PDTI  agree to  amend  the  License  Agreement  according  to the
following terms and conditions:

Section 1.06.01 shall be inserted:

          "1.06.01   Ophthalmology   Effective  Date.  The  term  "Ophthalmology
          Effective Date" as used herein shall mean ___ of _________ , 1996."

Section 1.08 shall be deleted and replaced by:

          "1.08  Fields.  The term "Fields" as used herein shall mean the fields
          of Oncology, Urology, Dermatology and Ophthalmology,  unless otherwise
          indicated."

Section 1.24 shall be inserted as follows:

           "1.24 Other Indications.  The term "Other Indications" as used herein
           shall mean the  indications  in the  Fields as set forth in  Schedule
           1.24. The parties will agree on additional Other Indications  through
           the Operating Committee, based on criteria including, but not limited
           to, *****, ***** and ***** ."

The numbering on the remainder of Article I shall be amended accordingly.

Section 1.35 shall be deleted and replaced by:

          "1.35  Schedules.  The Schedules  which are attached to this Agreement
          and  which  are  herein   incorporated,   are  as  follows:   Schedule
          Description
                     1.17                 Major Indications
                     1.18                 Minor Indications
                     1.24                 Other Indications
                     3.04                 Key Countries
The following shall be added at the end of Section 3.01:

           "Pharmacia   intends  to  sublicense  its  rights  in  the  Field  of
           Ophthalmology to its affiliate,  Pharmacia & Upjohn AB. In respect to
           such Field, the parties intend for such affiliate to make all royalty
           and other  payments,  exercise all rights and perform all obligations
           directly to PDT."

Section 3.04.01 shall be inserted as follows:

           "3.04.01 Ophthalmology Milestones. Notwithstanding anything herein to
           the contrary, for Ophthalmology Major and Minor Indications Pharmacia
           shall pay PDTI only the following sums upon achievement of the stated
           milestones:

     (i) if,  after  conducting  *****  for any  Ophthalmology  Major  and Minor
Indication,  the Ophthalmology Operating Committee decides to proceed with *****
for such indication,  Pharmacia shall pay PDTI: ***** for each Major Indication;
and ***** for each Minor Indication;  or in the event ***** are not required for
any  indication  and the  Operating  Committee  decides to proceed  with  *****,
Pharmacia shall not owe PDTI a ***** milestone payment for each such indication;
and

     (ii) for each  Major and Minor  Indication,  at the ***** in one or more of
the Key Countries as specified by Schedule 3.04,  Pharmacia shall pay PDTI *****
for each Major  Indication so approved,  and ***** for each Minor  Indication so
approved.

     (iii)  Pharmacia  shall  not owe  PDTI any  milestone  payments  for  Other
Indications in Ophthalmology."


*****Confidential Treatment Requested

<PAGE>

Section 3.05.01 shall be inserted as follows:

           "3.05.01 Ophthalmology Royalties.  Notwithstanding anything herein to
           the contrary,  for Ophthalmology,  Pharmacia or Pharmacia & Upjohn AB
           shall, for the term of the license specified by Section 3.02, pay PDT
           royalties  on Net Sales of  Product  to third  parties at the rate of
           ***** on total Net Sales of Product of *****, per calendar year and a
           royalty of ***** on the part of total Net Sales of Product  ***** per
           calendar year, *****.

Section 3.12 shall be inserted as follows:

           "3.12 Reimbursement.  Within fifteen (15) business days following the
           Ophthalmology  Effective Date, Pharmacia shall pay to PDTI the sum of
           Five Hundred Thousand US Dollars  ($500,000),  as  reimbursement  for
           prior  expenses  incurred  by PDTI in the  development  of SnET2  for
           Ophthalmology."

Section 4.01.01 shall be inserted as follows:

           "4.01.01  Ophthalmology  Strategic  Plan.   Notwithstanding  anything
           herein to the contrary,  for Ophthalmology,  the Strategic Plan shall
           be governed by the following provision: Unless otherwise agreed to by
           the  parties,  within one hundred  twenty  (120) days  following  the
           Ophthalmology  Effective  Date, the parties shall mutually  develop a
           written  plan,  the format and content as set forth in Section  4.01,
           with  respect  to  Ophthalmology.  This  plan  shall  be  called  the
           "Ophthalmology  Strategic Plan".  References to the Strategic Plan in
           the remainder of the Agreement shall also apply to the  Ophthalmology
           Strategic Plan, unless otherwise indicated."

Section 4.02.01 shall be inserted as follows:

          "4.02.01  Ophthalmology Steering Committee.  Notwithstanding  anything
          herein to the contrary, for Ophthalmology,  there shall be no Steering
          Committee.  References  to the Steering  Committee in the remainder of
          the Agreement shall apply to the Ophthalmology  Operating Committee as
          defined in Section 4.03.01, unless otherwise indicated."

Section 4.03.01 shall be inserted as follows:

           "4.03.01 Ophthalmology Operating Committee.  Notwithstanding anything
           herein to the contrary,  for Ophthalmology,  the Operating  Committee
           shall be governed by the following provision: Unless otherwise agreed
           to  by  the  parties,   within   thirty  (30)  days   following   the
           Ophthalmology   Effective   Date,   the  parties   shall  appoint  an
           "Ophthalmology  Operating  Committee",   having  the  membership  and
           purpose  as  set  forth  in  Section   4.03,   with  respect  to  the
           Ophthalmology  Strategic Plan.  References to the Operating Committee
           in  the  remainder  of  the   Agreement   shall  also  apply  to  the
           Ophthalmology Operating Committee, unless otherwise indicated."

Section 4.09.01 shall be inserted as follows:

          "4.09.01 SnET2 for Ophthalmology.  Notwithstanding  anything herein to
          the contrary,  for Ophthalmology,  unless otherwise  determined by the
          Ophthalmology  Operating  Committee,  PDTI  shall be  responsible  for
          conducting  all necessary  Preclinical  Tests and Phase I and Phase II
          Clinical Tests for SnET2 to be used in any  Ophthalmology  indications
          within  the  Fields.  The  Out-of-Pocket   Expenses   associated  with
          Preclinical Tests, Phase I and Phase II Clinical Tests being conducted
          by  PDT on the  Ophthalmology  Effective  Date,  or  conducted  by PDT
          thereafter,  shall be  refunded  by  Pharmacia,  provided  that  these
          studies  have  been  conducted  in  agreement  with the  Ophthalmology
          Operating Committee. Pharmacia shall be responsible for conducting and
          shall bear all costs associated with Phase III Clinical Tests of SnET2
          to be  used  in all  Ophthalmology  indications,  as  well  as for all
          post-NDA approval studies which may be necessary;  provided,  however,
          that the Ophthalmology Operating Committee has the right to determine,
          in its reasonable  judgment,  whether to proceed to Phase III Clinical
          Tests  as to  any  Ophthalmology  indication.  PDTI  shall  supply  to
          Pharmacia  SnET2 and Light  Devices to enable  Pharmacia  to carry out
          Phase III  Clinical  Tests  required to support an NDA for SnET2.  The
          actual costs of SnET2 and Light  Devices for all Clinical  Test phases
          shall be shared equally by the parties hereto."

Article XVI "Ophthalmology Negotiation" shall be deleted.


*****Confidential Treatment Requested

<PAGE>


Schedule 1.17 shall be deleted and replaced by:

           "SCHEDULE 1.17  Major Indications.
           *****

 Schedule 1.18 shall be deleted and replaced by:

           "SCHEDULE 1.18  Minor Indications.
           *****

Schedule 1.24 shall be inserted as follows:

           "SCHEDULE 1.24  Other Indications.
           *****


The parties shall revise the SnET2 Device Supply and Product Supply  Agreements,
dated July 1st, 1995, to reflect the field of Ophthalmology as appropriate.


           IN WITNESS  WHEREOF,  the parties hereto have caused this Development
and License  Agreement to be executed in duplicate by their respective  officers
duly authorized as of the date first above written.


PDT, INC.
By

Name:

Title:


PHARMACIA S.p.A.

By

Name:

Title:


PHARMACIA & UPJOHN AB

By:

Name:

Title:
















*****Confidential Treatment Requested




<PAGE>



                                  Exhibit 10.3




                         EMPLOYEE LOAN PROGRAM AGREEMENT


           The undersigned  (the "Employee") is the holder of the Employee Stock
Option(s) (the  "Option(s)")  issued by PDT, Inc., a Delaware  corporation  (the
"Company") described in Exhibit B.

           The  Employee  has  requested  to borrow the Loan  Amount  identified
below, but not exceeding  $25,000.00 in the aggregate,  from the Company and the
Employee has agreed to execute and deliver the  Employee  Loan  Promissory  Note
(the "Note") in the form attached hereto as Exhibit A.

           The  Employee  has  reviewed  the terms of the Note and  agrees to be
bound by the terms thereof.

           The  Employee  grants a security  interest  in the  Option(s)  to the
Company to secure the obligations under the Note and will deliver to the Company
the Employee's  original copy of the Option(s) with such  instrument of transfer
as the Company shall request.  By its  acceptance of the Option(s),  the Company
consents to such  transfer of the  Option(s).  The Employee also agrees that the
Option(s)  constitute  a  "security"  and (i) in the event of a  default  by the
Employee  under the terms of the Note,  the  Company may set off and utilize the
Option(s) or the shares  underlying  the Option(s) for the purpose of paying the
principal  and  interest  due  pursuant to the Note,  (ii) the Company  shall be
entitled to receive  from the proceeds of the sale of any stock  underlying  any
Company stock option funds sufficient to repay this Note and (iii) any such sale
proceeds  shall be remitted by any selling broker  directly to the Company.  The
Employee  further  represents  that the  proceeds of the loan under the Employee
Loan  Program are not for the purpose of  purchasing  or carrying  margin  stock
within the meaning of Regulation G promulgated by the Federal  Reserve Board and
the Employee  agrees to execute and deliver  prior to funding such  statement of
purpose as shall be required under such regulation.

           The  Employee  hereby  acknowledges,  ratifies and affirms all of the
remaining terms and conditions of the Option(s).

          In Witness Whereof the  undersigned  have duly executed this Agreement
on the respective dates indicated.

                                    PDT, INC.

                                    By:
- --------------------------          --------------------------------------------
Date                                Title: Chief Financial Officer

                                    Employee


- -------------------------           --------------------------------------------
Date




<PAGE>




                                    Exhibit A

                          Employee Loan Promissory Note




<PAGE>


                          EMPLOYEE LOAN PROMISSORY NOTE


$25,000                                                       Santa Barbara, CA
                                                              Date:


     FOR    VALUE    RECEIVED,    _____________________,    (the    "Employee"),
unconditionally promises to pay to the order of PDT, INC. (the "Company"), whose
address is 7408 Hollister Avenue, Santa Barbara, California 93117, in the manner
and at the place  hereinafter  provided,  the  principal  amount of Twenty  Five
Thousand and  00/100ths  Dollars  ($25,000.00)  (or such lesser  amount as shall
equal the aggregate  unpaid principal amount of the loans made by the Company to
the Employee under the Company's Employee Loan Program),  together with interest
at the rate  established from time to time by the Department of the Treasury and
defined as the annual Applicable Federal Rate, which shall accrue and be payable
together with the principal  amount hereof upon the earlier of: (i)  termination
of Employee's  employment with Company,  (ii) Employee's election to exercise of
any Company stock option held by Employee,  or (iii) the earliest  expiration of
the employee  stock  option(s)  described  in  Paragraph 7 below (the  "Maturity
Date").

     The  Employee  also  promises to pay on the Maturity  Date  interest on the
unpaid  principal  amount  hereof as it  exists  from time to time from the date
hereof until paid in full.  All  computations  of interest  shall be made by the
Company on the basis of a 360-day year and the actual  number of days elapsed in
the relevant  period.  In no event shall the interest  rate payable on this Note
exceed the maximum  rate of interest  permitted to be charged  under  applicable
law.

     The date and amount of each loan made by the Company to the  Employee,  and
each payment made on account of the principal of such loan(s), shall be recorded
by the Company on its books and, prior to any transfer of this Note, endorsed by
the Company on the schedule  attached to this Note or any  continuation  of such
schedule,  provided that the failure of the Company to make any such recordation
or  endorsement  shall not  affect the  obligations  of the  Employee  to make a
payment when due of any amount  owing under the  Employee  Loan Program or under
this Note in respect of the loans made by the Company.

     This Note is the Employee Loan  Promissory Note referred to in the Employee
Loan Program  Agreement (as modified and supplemented and in effect from time to
time, the "Loan  Agreement")  between the Company and the Employee and evidences
loans made by the Company under the Loan Agreement.

     1. PAYMENTS. All payments of principal and interest in respect of this Note
shall be made in lawful money of the United  States of America to the Company at
the  address  specified  by the  Company,  or at such  other  place  as shall be
designated in a written notice  delivered to the Employee.  Whenever any payment
on this Note shall be stated to be due on a day that is not a business day, such
payment shall instead be made on the next succeeding  business day. Each payment
made hereunder shall be credited first to interest then due and the remainder of
such payment shall be credited to principal,  and interest shall thereupon cease
to accrue upon the principal portion so credited.


     2. LATE PAYMENT CHARGES. A late payment charge of five percent (5%) will be
payable by the  Employee to the Company for any payment not made within ten (10)
days of its due date (including the Maturity Date).

     3. COVENANT. The Employee covenants and agrees that until this Note is paid
in full,  they will  promptly,  after the  occurrence of an Event of Default (as
hereinafter  defined) or an event, act or condition which,  with notice or lapse
of time or both, would constitute an Event of Default,  provide the Company with
a certificate specifying the nature thereof and the Employee's proposed response
thereto.

     4. EVENTS OF DEFAULT.  The occurrence of any of the following  events shall
constitute an "Event of Default":

     (a)  failure of the Employee to pay any principal, interest or other amount
          due under this Note when due,  whether at the due date,  the  Maturity
          Date, by acceleration, or otherwise;

     (b)  sale, conveyance or transfer of any option(s) which secure this Note;

     (c)  the Employee  shall die or shall admit in writing its inability to, or
          be generally unable to, pay its debts as such debts become due;

     (d)  (i) a court having  jurisdiction  in the premises shall enter a decree
          or order for relief in respect of the Employee in an involuntary  case
          under Title 11 of the United States Code entitled "Bankruptcy" (as now
          and hereinafter in effect, or any successor  thereto,  the "Bankruptcy
          Code") or any applicable  bankruptcy,  insolvency or other similar law
          now or  hereafter in effect,  which decree or order is not stayed;  or
          any other similar relief shall be granted under any applicable federal
          or state law; or (ii) an involuntary  case shall be commenced  against
          the Employee  under any  applicable  bankruptcy,  insolvency  or other
          similar law now or hereafter in effect; or

     (e)  an order for relief  shall be entered  with respect to the Employee or
          the Employee shall commence a voluntary case under the Bankruptcy Code
          or any applicable  bankruptcy,  insolvency or other similar law now or
          hereafter  in  effect,  or shall  consent to the entry of an order for
          relief in an involuntary  case, or to the conversion of an involuntary
          case to a voluntary case,  under any such law, or shall consent to the
          appointment  of or taking  possession by a receiver,  trustee or other
          custodian  for  all or a  substantial  part  of its  property;  or the
          Employee shall make an assignment for the benefit of creditors; or the
          Employee  shall be unable or fail,  or shall  admit in  writing  their
          inability to pay its debts as such debts become due.

     5.   REMEDIES.  Upon the  occurrence  of any Event of Default  specified in
          Paragraph 4 above,  the principal  amount of this Note,  together with
          accrued interest  thereon,  shall become  immediately due and payable,
          without presentment,  demand, notice, protest or other requirements of
          any kind (all of which are hereby  expressly  waived by the Employee),
          and upon the occurrence and during the  continuance of any other Event
          of  Default,  the  Company  may,  by written  notice to the  Employee,
          declare  the  principal  amount of this Note,  together  with  accrued
          interest  thereon to be due and payable,  and the principal  amount of
          this Note,  together with such interest,  shall thereupon  immediately
          become due and payable without presentment, further notice, protest or
          other  requirements  of any kind  (all of which are  hereby  expressly
          waived by the Employee). Upon any such acceleration of the amounts due
          under this Note or upon the  Maturity  Date,  the Company may withhold
          from, exercise or setoff against any security for this Note, including
          the employee stock option(s)  securing this Note, amounts necessary to
          repay this Note.  The  Employee  further  agrees  that (i) the Company
          shall be  entitled  to receive  from the  proceeds  of the sale of any
          stock  underlying  any Company stock option funds  sufficient to repay
          this Note and (ii) any such sale  proceeds  shall be  remitted  by any
          selling broker directly to the Company.

     6. MISCELLANEOUS.

     (a)  All notices and other  communications  provided for hereunder shall be
          in writing (including telecopier communication) and mailed, telecopied
          or  delivered as follows:  if to the  Employee,  (i) at their  address
          specified opposite their signature below or (ii) at their inter-office
          mail box; and if to the Company,  at the address for payment set forth
          in  Section 1 above;  in each case at such  other  address as shall be
          designated  by the Company or the Employee in a written  notice to the
          other.  All  such  notices  and  communications  shall,  when  mailed,
          telecopied or sent by overnight  courier,  be effective when deposited
          in  the  mails,  delivered  to  the  overnight  courier,  or  sent  by
          telecopier  and,  when hand  delivered or deposited in the  Employee's
          inter-office  mail box, be effective  when deposited in such mail box.

     (b)  The  Employee  agrees to  indemnify  the  Company  against any losses,
          claims,  damages  and  liabilities  and  related  expenses,  including
          counsel fees and expenses,  incurred by the Company  arising out of or
          in connection with or as a result of the transactions  contemplated by
          this Note. In particular,  the Employee  promises to pay all costs and
          expenses, including reasonable attorneys' fees, incurred in connection
          with the collection and enforcement of this Note.

     (c)  No failure or delay on the part of the Company or any other  holder of
          this Note to exercise any right,  power or  privilege  under this Note
          and no course of dealing  between the Employee  and the Company  shall
          impair such right,  power or  privilege  or operate as a waiver of any
          default or an  acquiescence  therein,  nor shall any single or partial
          exercise of any such right,  power or privilege  preclude any other or
          further exercise thereof or the exercise of any other right,  power or
          privilege.  The rights and  remedies  herein  expressly  provided  are
          cumulative  to, and not exclusive of, any rights or remedies which the
          Company would  otherwise  have. No notice to or demand on the Employee
          in any case shall entitle the Employee to any other or further  notice
          or demand in similar or other  circumstances or constitute a waiver of
          the  right of the  Company  to any  other  or  further  action  in any
          circumstances without notice or demand.

     (d)  The Employee and any endorser of this Note hereby  consent to renewals
          and  extensions  of time at or  after  the  maturity  hereof,  without
          notice, and hereby waive diligence,  presentment,  protest, demand and
          notice of every kind and, to the full  extent  permitted  by law,  the
          right to plead any statute of  limitations  as a defense to any demand
          hereunder.

     (e)  THIS NOTE, AND THE RIGHTS AND  OBLIGATIONS  OF THE PARTIES  HEREUNDER,
          SHALL BE GOVERNED BY, AND CONSTRUED  AND ENFORCED IN ACCORDANCE  WITH,
          THE LAWS OF THE STATE OF CALIFORNIA.

     (f)  THE TERMS OF THIS NOTE CONTAIN A BALLOON PAYMENT.

     (g)  This Note may be prepaid without penalty.

     7.  SECURITY.  This Note is  secured by a pledge of the  required  employee
stock  option(s)  and shares  underlying  such  option(s)  as  described  in the
Employee Loan Program Agreement executed by the Employee.

     IN WITNESS  WHEREOF,  the  Employee has caused this Note to be executed and
delivered as of the day and year and at the place first above written.

                               EMPLOYEE:



                               -----------------------------------------
                               Signature


                               Address:




<PAGE>


                                           SCHEDULE OF LOANS

     This Note evidences loans made under the Loan Agreement to the Employee, on
the dates and in the principal amounts set forth below,  subject to the payments
and prepayments of principal set forth below:

<TABLE>
<CAPTION>

<S>                   <C>                     <C>                    <C>                     <C>

- --------------------- ----------------------- ---------------------- ----------------------- --------------
 Date Made                 Principal Amount           Amount Paid              Unpaid           Notation
                                of Loan               or Prepaid          Principal Amount      Made By
- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------

- --------------------- ----------------------- ---------------------- ----------------------- --------------
</TABLE>


<PAGE>


                                    PDT, INC.
                              EMPLOYEE LOAN PROGRAM
                               SUMMARY DESCRIPTION


General:

Under the PDT, Inc.  Employee Loan Program (the "Loan  Program"),  Employees may
borrow from PDT, Inc. (the  "Company") an amount up to a maximum of  $25,000.00,
which will be due and payable at a specified period in the future. Interest will
accrue  quarterly  and will be due and payable upon the loan due date. To secure
the loan,  employees will be required to pledge their vested stock options which
will be adjusted in the future based on the fair market value.


Loan Details:

Loan  Limit:  The loan will be the lesser of 25% of the  employee's  vested gain
value in their unexercised options pledged to secure the loan or $25,000.00. The
$25,000.00  represents  a lifetime  maximum  that can be borrowed by an employee
under the Loan Program.

Vested Gain Value:  The vested gain will be determined  based on the average per
share closing price of the Company's stock as quoted on Nasdaq for the preceding
month of the enrollment  period less the option  exercise price times the number
of vested shares. An increase in the vested gain value of pledged options allows
an employee to borrow additional funds, up to the plan maximums,  and a decrease
in the vested gain value may require a pledge of additional options.

Dates and Amounts of Loans:  Subsequent  to the initial  enrollment  period,  an
employee  who has not  reached the  maximum of  $25,000.00  in loans may have an
opportunity to receive  additional loans during subsequent  enrollment  periods.
This may occur if the employee, (i) vests additional options, or (ii) the vested
gain value increases.  The employee must complete the Enrollment  Application to
request the additional loan amounts.

Security  Interest:  The employee agrees to give the Company a security interest
in their  unexercised  vested  options  and will  deliver to the  Company  their
original copy of those Option  Agreements as determined by the Company  required
to secure  the loan.  As the number of shares  required  to secure the loan will
fluctuate  from time to time based on the market  price per share,  and  because
accrued  interest  will be  accumulating  over the term of the loan,  additional
Option  Agreements  may be  requested  to be  provided  to the Company and those
Option Agreements  requested and delivered will be retained by the Company until
such time as the outstanding principal loan and interest amount is repaid.

Loan Due Date:  The loan due date will be the  earlier  of: (i)  termination  of
employment with the Company, (ii) the date of any election to exercise a Company
option held by the employee or (iii) the earliest option expiration date. On the
loan  due  date  the  outstanding  loan  amount,  including  cumulative  accrued
interest, will be due.

Interest:  Interest  will  be  accrued  and  compounded  quarterly  at  the
Applicable Federal Rate. The cumulative accrued interest will be due and payable
at the loan due date.

Payment of Loan:  Upon the loan due date,  payment  shall be made to the Company
for the principal loan amount and the accrued interest. If the employee does not
have the funds to repay the loan, the Company may offset and utilize the Options
or shares  underlying  the Options for the purpose of paying the  principal  and
interest  due.  The number of shares  needed for such offset will be  determined
based on the total loan amount and cumulative  accrued  interest  divided by the
per share price of the stock as quoted on Nasdaq as of the close of business for
the  preceding  day of the period  being  measured.  If an  employee  chooses to
exercise and sell their  options,  the employee  agrees that the principle  loan
amount and accrued  interest  will be paid out of the sale proceeds and remitted
by the broker to the Company on the employee's behalf. A late payment charge may
be applied to the outstanding amount and accrued interest.

Loan  Enrollment:  An employee will be able to apply for a loan from the Company
four times a calendar year. The enrollment  periods will last  approximately one
week during dates announced by the company.

Tax Impact: Upon repayment of the cumulative accrued interest, the employee will
receive notification of the amount paid to be used for possible tax purposes. If
all or a portion of the loan is  considered  to be  forgiven,  then that portion
which is  forgiven  will be  considered  compensation  to the  employee  and the
related employment taxes may be due from the employee.


Eligibility:

Loan  eligibility  is  determined  based on  salary  level,  employment  length,
employee reviews (need satisfactory review on latest review),  employee's number
of vested unexercised  options, the expiration date of the employee's option and
the employee's unexercised vested option value. Additionally,  the employee will
not have  exercised  any of their  options  since the  commencement  of the loan
program. Notwithstanding the above, any loan made under the Loan Program will be
at the Company's discretion.


Termination:

The Loan Program may be suspended or terminated at any time by the Company. Upon
and during any  suspension  or  termination,  the Company  will not fund further
loans  under  the Loan  Program,  including  loans in  respect  of  applications
received by the Company but as to which the Company has not yet funded. Existing
loans will continue to be governed by the terms of the Employee Loan Agreement.

<TABLE>
<CAPTION>
Examples:

Initial Loan Date
- -----------------
<S>                                             <C>

Number of Shares underlying the Option........  5,000
Number of Vested Shares.......................  2,000
Exercise Price per Share......................  $10.00
Average Nasdaq Closing Price per Share........  $30.00
Gain Value per Share..........................  $20.00  (FMV per share less per share exercise price)
Vested Gain Value.............................  $40,000 (2,000 share times 20.00($30.00 - $10.00))


Loan Amount...................................  $10,000 ($40,000*25%) not to exceed $25,000

Vested Options Shares Pledged as of Loan Date.  500 ($10,000/$20.00 per share)


Six Months Later
- ----------------
Average Nasdaq Closing per Share..............  $60.00
Gain Value per Share..........................  $50.00
Vested Gain Value.............................  $100,000 ($50.00 per share * 2,000 shares)
Maximum Loan Amount...........................  $25,000
Less: Previously Loaned Amount................  $10,000
Additional Available Loan Amount..............  $15,000

Total loan Amount.............................  $25,000

Total Vested Option Shares Pledged............  500 ($25,000/$50.00 per share)
</TABLE>





<PAGE>
                                  Exhibit 10.4





================================================================================
                                    PDT, INC.
================================================================================
================================================================================
                               AMENDMENT NO. 3 TO
================================================================================
================================================================================
                           1989 STOCK OPTION AGREEMENT
================================================================================
     THIS AMENDMENT NO. 3 TO PDT, INC. NONSTATUATORY STOCK OPTION AGREEMENT (the
"Amendment") is made and entered into at Santa Barbara,  California, on the date
hereinafter  set  forth  by  and  between  PDT,  Inc.,  a  Delaware  corporation
(hereinafter, the "Company") and the undersigned (hereinafter, the "Optionee").
WHEREAS:

     A. The Company and the Optionee are parties to a Nonstatuatory Stock Option
Agreement No. ___ dated ____ and  Amendments 1 and 2 thereto (the  "Agreement";
and

     B. The Company and the Optionee  hereby wish to extend the expiration  date
of the Option Agreement.

NOW,  THEREFORE,   in  consideration  of  the  premises  and  the  promises  and
representations hereinafter contained, it is agreed as follows:

     1.  Section  3 (b) of the  Agreement  is  hereby  amended  to  read  in its
entirety:

     3. (b) Expiration Date.  Except as otherwise  provided  herein,  the Option
shall expire at 5:00 p.m.,  Los Angeles,  California  time on or before ten (10)
years from the date of grant of this Option.  Notwithstanding the foregoing,  if
Participant  ceases  to be an  Employee  for any  reason  other  than  death  or
permanent  disability within the meaning of Section 105(d) (4) of the Code, this
Option shall: (i) expire 30 days after the first day Participant is no longer an
Employee, if the shares issuable under the 1989 Plan have been registered by the
Company with the  Securities  and Exchange  Commission  (SEC) on an  appropriate
registration statement, but in no event later than the expiration date specified
under  this  subparagraph  (b);  or (ii)  expire  one year  after  the first day
Participant is no longer an Employee, if the shares issuable under the 1989 Plan
have not been registered by the Company with the SEC, but in no event later than
the expiration  date specified under this  subparagraph  (b); or (iii) expire 30
days after the shares  issuable under the 1989 Plan have been  registered by the
Company with the SEC on an appropriate registration statement if the Participant
is no longer an Employee at the time of the SEC registration and contingent upon
written notice to the Participant by the Company of such SEC  registration,  but
in no event later than the  expiration  date specified  under this  subparagraph
(b).

     If Participant  dies while an Employee or ceases to be an Employee  because
of his or  her  permanent  disability  as  defined  above,  this  Option  may be
exercised by the personal  representative  of the estate of Participant  (or, if
Participant's  estate has been closed,  by his or her  successors  by bequest or
inheritance) or by the Participant, respectively, for a period of six (6) months
after  Participant  ceases to be an  Employee,  but in no event  later  than the
expiration  date specified under this  subparagraph  (b). If this Option remains
exercisable pursuant to this subparagraph (b) after termination of Participant's
employment,  the Option may be exercised  only to the extent  Participant  could
have exercised the Option pursuant to subparagraph  (c) on the date  Participant
ceased to be an Employee.

     2. Except as amended above, the Agreement is hereby ratified, confirmed and
approved in its entirety and in all other respects.

     3. The Effective Date of this Amendment is July 31, 1996.

     IN WITNESS  WHEREOF,  the parties hereto have executed this Amendment to be
effective on the date written above.

"PDT"                                               The "Optionee"
PDT, Inc.,                                          NAME
a Delaware Corporation

By: _______________________________       _________________________________
           Gary S. Kledzik, Ph.D.
           C.E.O. and Chairman




<PAGE>

<TABLE>
<CAPTION>

                                                                            EXHIBIT 11.1
                                                               COMPUTATION OF NET LOSS PER SHARE
                                                                            (Unaudited))


                                              THREE MONTHS ENDED SEPTEMBER 30,     NINE MONTHS ENDED SEPTEMBER 30,
                                             ---------------------------------     ----------------------------------
                                                   1996               1995               1996              1995
                                              ---------------  ---------------     ----------------   ---------------
<S>                                           <C>                <C>                   <C>            <C>
PRIMARY
Net loss .................................... $   (4,155,000)  $   (2,668,000)     $   (12,639,000)   $   (6,826,000)
                                              ===============  ===============     ================   ===============

Weighted average common shares outstanding ..     12,438,069       10,283,104           11,519,785         9,679,164
                                              ---------------  ---------------     ----------------   ---------------
Net loss per share .......................... $        (0.33)  $        (0.26)     $         (1.10)   $        (0.71)
                                              ===============  ===============     ================   ===============



FULLY DILUTED
Net loss ....................................  $  (4,155,000)  $   (2,668,000)     $   (12,639,000)   $   (6,826,000)
                                              ===============  ===============     ================   ===============

Weighted average common shares outstanding ..     12,438,069       10,283,104           11,519,785         9,679,164
                                              ---------------  ---------------     ----------------   ---------------
Net loss per share .......................... $        (0.33)  $        (0.26)     $         (1.10)   $        (0.71)
                                              ===============  ===============     ================   ===============

</TABLE>

<TABLE> <S> <C>


<ARTICLE>                     5
<LEGEND>
     THIS SCHEDULE  CONTAINS SUMMARY  FINANCIAL  INFORMATION  EXTRACTED FROM THE
CONSOLIDATED  BALANCE SHEETS AND CONSOLIDATED  STATEMENTS OF OPERATIONS FOUND ON
PAGES 3 AND 4 OF THE  COMPANY'S  FORM 10-Q FOR THE PERIOD  ENDING  SEPTEMBER 30,
1996,  AND  IS  QUALIFIED  IN  ITS  ENTIRETY  BY  REFERENCE  TO  SUCH  FINANCIAL
STATEMENTS.

</LEGEND>

<MULTIPLIER>                   1,000
       
<S>                            <C>
<PERIOD-TYPE>                  9-MOS
<FISCAL-YEAR-END>              DEC-31-1996
<PERIOD-START>                 JAN-01-1996
<PERIOD-END>                   SEP-30-1996
<CASH>                           40,816
<SECURITIES>                     20,100
<RECEIVABLES>                     1,884
<ALLOWANCES>                          0
<INVENTORY>                          15
<CURRENT-ASSETS>                 63,348
<PP&E>                            4,069
<DEPRECIATION>                   (1,609)
<TOTAL-ASSETS>                   66,086
<CURRENT-LIABILITIES>             2,554
<BONDS>                              48
                 0
                           0
<COMMON>                        112,550
<OTHER-SE>                       49,066
<TOTAL-LIABILITY-AND-EQUITY>     66,086
<SALES>                               5
<TOTAL-REVENUES>                  2,230
<CGS>                                 5
<TOTAL-COSTS>                    16,408
<OTHER-EXPENSES>                      0
<LOSS-PROVISION>                      0
<INTEREST-EXPENSE>                   27
<INCOME-PRETAX>                 (12,639)
<INCOME-TAX>                          0
<INCOME-CONTINUING>             (12,639)
<DISCONTINUED>                        0
<EXTRAORDINARY>                       0
<CHANGES>                             0
<NET-INCOME>                    (12,639)
<EPS-PRIMARY>                     (1.10)
<EPS-DILUTED>                     (1.10)
        


</TABLE>


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