MIRAVANT MEDICAL TECHNOLOGIES
S-3/A, 1997-12-05
PHARMACEUTICAL PREPARATIONS
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AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON DECEMBER 5, 1997
                                                      REGISTRATION NO. 333-39905
    
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- --------------------------------------------------------------------------------
                          SECURITIES AND EXCHANGE COMMISSION
                                WASHINGTON, D.C. 20549
                                  -----------------
   
                                    AMENDMENT NO. 1
                                         TO
    
                                       FORM S-3
                                REGISTRATION STATEMENT
                                        UNDER
                              THE SECURITIES ACT OF 1933
                                  -----------------
                            MIRAVANT MEDICAL TECHNOLOGIES
                (Exact name of registrant as specified in its charter)

              DELAWARE                                     77-0222872
    (State or Other Jurisdiction of                     (I.R.S. Employer
    Incorporation or Organization)                    Identification Number)
                                7408 HOLLISTER AVENUE
                           SANTA BARBARA, CALIFORNIA 93117
                                    (805) 685-9880
(Address, including zip code, and telephone number, including area code, of
                      registrant's principal executive offices)


                                GARY S. KLEDZIK, PH.D.
                         CHAIRMAN AND CHIEF EXECUTIVE OFFICER
                            MIRAVANT MEDICAL TECHNOLOGIES
                                 7408 HOLLISTER AVE.
                           SANTA BARBARA, CALIFORNIA 93117
                                    (805) 685-9880
(Name, address, including zip code, and telephone number, including area code,
of agent for service)
                                  -----------------
                                      COPIES TO:
    JOSEPH E. NIDA, ESQ.                         JAMES L. NOUSS, JR., ESQ.
   THEODORE R. MALONEY, ESQ.                      ELIZABETH A. KING, ESQ.
NIDA & MALONEY, A PROFESSIONAL CORPORATION            BRYAN CAVE LLP
    800 ANACAPA STREET                            120 BROADWAY, SUITE 500
  SANTA BARBARA, CALIFORNIA 93101              SANTA MONICA, CALIFORNIA  90401
      (805) 568-1151                                   (310) 576-2100
                                -----------------

           APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:
        FROM TIME TO TIME AFTER THIS REGISTRATION STATEMENT BECOMES EFFECTIVE.

                                  -----------------
    If the only securities being registered on the form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. / /
    If any of the securities registered on this form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. /x/
    If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. / /
    If this Form is a post-effective amendment filed pursuant to
Rule 462(c) under the Securities Act, check the following box and list the
Securities Act registration statement number of the earlier effective
registration statement for the same offering. / /
    If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. / /
                                  -----------------
                           CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>

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                                                                 PROPOSED MAXIMUM         PROPOSED MAXIMUM
                                            AMOUNT OF SHARES    OFFERING PRICE PER       AGGREGATE OFFERING          AMOUNT OF
TITLE OF SECURITIES TO BE REGISTERED        TO BE REGISTERED         SHARE                     PRICE              REGISTRATION FEE
- -----------------------------------------------------------------------------------------------------------------------------------

<S>                                         <C>                 <C>                      <C>                      <C>
Common Stock, par value $.01 per share      3,540,000 (1)            $56.00 (2)             $198,240,000 (2)        $60,072.73 (3)
- -----------------------------------------------------------------------------------------------------------------------------------
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</TABLE>
   

(1) Includes 1,416,000 shares of Common Stock of Miravant Medical 
    Technologies (the "Company" or the "Registrant") issuable upon exercise 
    of Common Stock Purchase Warrants (the "Warrants") and up to 708,000 
    shares of Common Stock which may be issued pursuant to the anti-dilution 
    provisions of the Warrants, as such number may be adjusted in accordance 
    with Rule 416, or the price protection provisions of Section 5.3 of the 
    Securities Purchase Agreement among the Company and the Selling 
    Shareholders named herein.
    
(2) Estimated pursuant to Rule 457(h) solely for the purpose of calculating the
    amount of the registration fee on the basis of the average of the high and
    low reported sale prices of a share of Common Stock of the Company on
    November 5, 1997 as reported by the Nasdaq National Market.
   
(3) Previously paid.
    

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                               3,540,000 SHARES
                                           
                                   MIRAVANT
                             MEDICAL TECHNOLOGIES
                                           
                                 COMMON STOCK
                                 ------------
   
    All of the shares of Common Stock of Miravant Medical Technologies, 
formerly PDT, Inc. (the "Company"), registered pursuant to the Registration 
Statement of which this Prospectus is a part (the "Shares") may be sold from 
time to time for the accounts of and by the persons named under the caption 
"Selling Shareholders."  The Shares include 1,416,000 shares of Common Stock 
issuable upon the exercise of Common Stock Purchase Warrants (the "Warrants") 
and 708,000 shares of Common Stock which may be issued pursuant to the 
anti-dilution provisions of the Warrants, as such number may be adjusted in 
accordance with Rule 416 of the Securities Act of 1933, as amended (the 
"Securities Act"), or the price protection provisions of Section 5.3 of the 
Securities Purchase Agreement among the Company and the Selling Shareholders. 
The Shares are subject to a Lock-Up Agreement which generally prohibits the 
sale of the Shares until September 1998, subject to certain exceptions. See 
"Selling Shareholders." The Selling Shareholders have advised the Company 
that the Shares may be sold from time to time on the Nasdaq National Market 
("NNM") or in negotiated transactions, in each case at prices satisfactory to 
the seller.  The Selling Shareholders and the brokers and dealers through 
which the sales of the Shares may be made may be deemed to be "underwriters" 
within the meaning set forth in the Securities Act, and their commissions and 
discounts and other compensation may be regarded as underwriters' 
compensation.  See "Plan of Distribution."  The Company has issued, or will 
issue upon the exercise of the Warrants, the Shares in certain Private 
Placement transactions.
    
    The Company will not receive any proceeds from the sale of Shares by the 
Selling Shareholders, but will receive the exercise prices payable upon the 
exercise of the Warrants, if exercised for cash.  There can be no assurance 
that all or any of the Warrants will be exercised or that they will be 
exercised for cash.  All expenses incurred in connection with this offering 
are being borne by the Company, other than any commissions or discounts paid 
or allowed by the Selling Shareholders to underwriters, dealers, brokers or 
agents.  
   
    The Common Stock of the Company is traded on the NNM under the symbol 
"MRVT." On December 3, 1997, the last sale price of the Common Stock as 
reported by the NNM was $44.625.
    
    THE COMMON STOCK OFFERED HEREBY INVOLVES A HIGH DEGREE OF RISK.  SEE "RISK
FACTORS" BEGINNING ON PAGE 4.

                                     ------------

    THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE
SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION PASSED
UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE
CONTRARY IS A CRIMINAL OFFENSE. 
   
December 5, 1997
    
      

<PAGE>

                                AVAILABLE INFORMATION

    The Company is subject to the informational requirements of the Securities
Exchange Act of 1934 (the "Exchange Act") and in accordance therewith files
reports, proxy statements and other information with the Securities and Exchange
Commission (the "Commission"). Reports, proxy statements and other information
filed by the Company can be inspected and copied at the public reference
facilities maintained by the Commission at Room 1024, 450 Fifth Street, N.W.,
Washington, D.C. 20549 and at the Commission's Regional Offices at Citicorp
Center, 500 West Madison Street, Suite 1400, Chicago, Illinois 60661 and Seven
World Trade Center, Suite 1300, New York, New York 10048. Copies of such
material can be obtained at prescribed rates from the Public Reference Branch of
the Commission at 450 Fifth Street, N.W., Washington, D.C. 20549.  The
Commission maintains a Web site that contains reports, proxy and information
statements and other materials that are filed through the Commission's
Electronic Data Gathering, Analysis and Retrieval (EDGAR) system.  This Web site
can be accessed at http://www.sec.gov.  Shares of the Company's Common Stock are
listed on the NNM and the reports, proxy statements and other information filed
by the Company also can be inspected at the offices of the National Association
of Securities Dealers, Inc. (the "NASD"), at 1735 K Street, N.W., Washington,
D.C. 20006.

    The Company has filed with the Commission a registration statement on Form
S-3 (the "Registration Statement") under the Securities Act with respect to the
Common Stock offered hereby. This Prospectus does not contain all the
information set forth in the Registration Statement, certain portions of which
have been omitted as permitted by the rules and regulations of the Commission.
Statements contained in this Prospectus as to the contents of any contract or
other document are not necessarily complete, and in each instance reference is
made to the copy of such contract or other document filed or incorporated by
reference as an exhibit to the Registration Statement, each such statement being
qualified in all respects by such reference and the exhibits and the schedules
thereto. For further information pertaining to the Company or the Common Stock
offered hereby, reference is made to the Registration Statement and such
exhibits and schedules thereto, which may be inspected without charge at, and
copies thereof may be obtained at prescribed rates from, the Public Reference
Branch of the Commission at 450 Fifth Street, N.W., Washington, D.C. 20549. 

                   INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

    This Prospectus incorporates documents by reference which are not presented
herein or delivered herewith, as indicated below. The Company will provide
without charge to each person to whom a copy of this Prospectus has been
delivered, on the written or oral request of such person, a copy of any or all
of the documents referred to below which are incorporated herein by reference
(other than exhibits to such documents unless they are specifically incorporated
by reference into such documents). Requests for such copies should be directed
to Corporate Secretary, Miravant Medical Technologies, 7408 Hollister Avenue,
Santa Barbara, California 93117; telephone number (805) 685-9880.

    The following documents filed with the Commission by the Company under File
No. 0-25544 pursuant to the Exchange Act are incorporated herein by reference:
Annual Report on Form 10-K for the fiscal year ended December 31, 1996;
Quarterly Reports in Forms 10-Q for the fiscal quarters ended March 31and June
30, 1997; Definitive Proxy Statement dated April 25, 1997; Definitive Consent
Solicitation Statement dated August 25, 1997; Current Reports on Form 8-K dated
September 15, September 26 and October 3, 1997; and description of the Company's
Common Stock as contained in Item 1 of the Company's Registration Statement on
Form 8-A filed February 9, 1995. 

    All documents filed by the Company with the Commission pursuant to
Section 13(a), 13(c), 14 or 15(d) of the Exchange Act on or after the date of
this Prospectus and prior to the termination of the offering of the Common Stock
offered hereby shall be deemed to be incorporated by reference herein and to be
a part hereof from the date of filing of such documents. See "Available
Information." Any statement contained in a document incorporated or deemed to be
incorporated by reference herein shall be deemed to be modified or superseded
for purposes of this Prospectus to the extent that a statement contained herein
or in any subsequently filed document incorporated or deemed to be incorporated
herein by reference, which statement is also incorporated herein by reference,
modifies or supersedes such statement. Any such statement so modified or
superseded shall not be deemed, except as so modified or superseded, to
constitute a part of this Prospectus.


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No person is authorized in connection with any offering made hereby to give any
information or to make any representation not contained in this Prospectus, and,
if given or made, such information or representation must not be relied upon as
having been authorized by the Company or any Selling Shareholder.  This
Prospectus does not constitute an offer to sell or a solicitation of an offer to
buy any of the securities offered hereby to any person in any jurisdiction in
which it is unlawful to make such an offer or solicitation.  Neither the
delivery of this Prospectus nor any sale made hereunder shall under any
circumstances create any implication that the information contained herein is
correct as of any date subsequent to the date hereof.


                                     THE COMPANY

    Miravant Medical Technologies is engaged in the integrated development of
drug and medical device products for use in PhotoPoint-TM- , the Company's
proprietary technologies for photodynamic therapy.  PhotoPoint is a medical
procedure which integrates the use of light-activated (photoreactive) drugs,
light producing devices and light delivery devices to achieve selective
photochemical destruction of diseased cells.  The Company believes that
PhotoPoint has the potential to be a safe, cost-effective, minimally invasive
primary or adjunctive treatment for indications in a broad number of disease
areas, including oncology, ophthalmology; urology, dermatology, gynecology and
cardiology. The Company is conducting clinical trials in oncology, dermatology
and ophthalmology; is preparing to initiate clinical trials in urology, oncology
and dermatology; and is conducting preclinical studies in oncology,
ophthalmology, urology, dermatology, gynecology and cardiology. All of the
Company's clinical trials are testing the Company's leading drug candidate, tin
ethyl etiopurpurin ("SnET2").  The Company is developing products in
collaboration with its corporate partners, Pharmacia & Upjohn, Inc.
("Pharmacia & Upjohn"), Boston Scientific Corporation ("Boston Scientific"),
Medicis Pharmaceutical Corporation ("Medicis"), Cordis Corporation, a Johnson &
Johnson company ("Cordis"), Iridex Corporation ("Iridex") and Ramus Medical
Technologies ("Ramus").

    PhotoPoint typically involves the intravenous injection of a photoreactive
drug followed by the application of light of a specific wavelength which
activates the drug. When exposed to the appropriate light wavelength, SnET2 acts
as a catalyst to generate a highly reactive form of oxygen which destroys the
membranes of the cells containing the drug. Importantly, neither SnET2 nor light
alone can produce the photodynamic reaction. After administration, SnET2 is
absorbed by cells throughout the body.  The drug begins to clear from normal
cells after several hours but is retained by hyperproliferating cells for up to
several days. As a result, PhotoPoint can be used to selectively destroy
diseased or undesirable cells in two ways: (i) DRUG
SELECTIVITY-hyperproliferating cells such as in a cancer tumor can be
selectively destroyed by allowing the drug to clear from non-target cells before
delivering light to the general area; and (ii) LIGHT SELECTIVITY-in conditions
such as certain eye disorders, tissues can be selectively destroyed by precisely
delivering the light to discrete areas before the drug has cleared. The Company
believes that this selectivity may offer advantages over existing chemotherapy,
radiation therapy and surgery treatments, which can damage both normal and
abnormal tissues. 

    The Company's objective is to develop and commercialize, with its corporate
partners, all three components of PhotoPoint: photoreactive drugs, light
producing devices and light delivery devices, for use as adjunct or primary
treatments. The key elements of the Company's strategy include: (i) integrating
photoreactive drugs, light producing devices and light delivery devices into
easy-to-use, cost-effective clinical treatment systems, (ii) initially targeting
high-incidence or serious diseases for which there is no satisfactory
alternative treatment or which may offer accelerated regulatory processes and
(iii) collaborating with industry-leading corporate partners who are leaders in
the Company's targeted disease areas and who can assist the Company in expanding
the number of target applications and expediting the development and marketing
of its products. 

    The Company was incorporated in Delaware in 1989 and, effective September
15, 1997, changed its name from PDT, Inc. to Miravant Medical Technologies.  The
Company's executive offices and the offices of its three subsidiaries, Miravant
Pharmaceuticals, Inc., Miravant Systems, Inc. and Miravant Cardiovascular, Inc.,
are located at 7408 Hollister Avenue, Santa Barbara, California 93117. The
Company's telephone number is (805) 685-9880.  Unless otherwise indicated, all
references to the Company include the Company and its subsidiaries.


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                                     RISK FACTORS

   THE COMPANY DOES NOT PROVIDE FORECASTS OF POTENTIAL FUTURE OPERATIONAL OR
FINANCIAL PERFORMANCE.  WHILE MANAGEMENT OF THE COMPANY IS OPTIMISTIC ABOUT THE
COMPANY'S LONG-TERM PROSPECTS, THE FOLLOWING ISSUES AND UNCERTAINTIES, AMONG
OTHERS, SHOULD BE CONSIDERED IN EVALUATING ITS OUTLOOK. THIS PROSPECTUS, AS WELL
AS THE INFORMATION INCORPORATED BY REFERENCE, CONTAINS FORWARD-LOOKING
STATEMENTS WITHIN THE MEANING OF THE PRIVATE SECURITIES LITIGATION REFORM ACT OF
1995, WHICH INVOLVE KNOWN AND UNKNOWN RISKS, UNCERTAINTIES AND OTHER FACTORS
WHICH MAY CAUSE THE ACTUAL RESULTS, PERFORMANCE OR ACHIEVEMENT OF THE COMPANY,
OR INDUSTRY RESULTS, TO DIFFER MATERIALLY FROM ANY FUTURE RESULTS, PERFORMANCE
OR ACHIEVEMENTS EXPRESSED OR IMPLIED BY SUCH FORWARD-LOOKING STATEMENTS. ACTUAL
RESULTS COULD DIFFER MATERIALLY FROM THOSE CONTEMPLATED BY SUCH STATEMENTS. THE
FACTORS LISTED BELOW REPRESENT CERTAIN IMPORTANT FACTORS THE COMPANY BELIEVES
COULD CAUSE SUCH RESULTS TO DIFFER. THESE FACTORS ARE NOT INTENDED TO REPRESENT
A COMPLETE LIST OF THE GENERAL OR SPECIFIC RISKS THAT MAY AFFECT THE COMPANY. IT
SHOULD BE RECOGNIZED THAT OTHER RISKS MAY BE SIGNIFICANT, PRESENTLY OR IN THE
FUTURE, AND THE RISKS SET FORTH BELOW MAY AFFECT THE COMPANY TO A GREATER EXTENT
THAN INDICATED.

EARLY STAGE OF THE COMPANY AND ITS PRODUCTS

    The Company and its products are in an early stage of development. No
revenues have been generated from sales of the Company's drugs and only limited
revenues have been generated from sales of the Company's devices. The Company
does not expect to achieve significant levels of revenues for at least several
years. The Company's revenues to date have consisted, and for the foreseeable
future are expected to consist, principally of grants awarded and payments for
its devices which are purchased by others engaged in preclinical and clinical
testing and research of photodynamic drugs or by companies that distribute the
devices and payments under research and development agreements, license fees,
royalties, clinical reimbursements, milestone payments and interest income. To
achieve profitable operations on a continuing basis, the Company, alone or with
collaborative partners, must successfully research, develop, test, obtain
regulatory approval, manufacture, introduce, market and distribute its products.
The time frame necessary to achieve these goals for any individual product is
long and uncertain. Most of the products currently under development by the
Company will require significant additional research and development,
preclinical and clinical testing and regulatory approval prior to
commercialization. There can be no assurance that the Company's research or
product development efforts or those of its collaborative partners will be
successfully completed, that the drugs or devices currently under development
will be successfully transformed into marketable products, that required
regulatory approvals can be obtained, that products can be manufactured at an
acceptable cost and with appropriate quality, that any approved products can be
successfully marketed, or that any products that may be marketed will be
favorably accepted. The likelihood of the Company's success must be considered
in light of these and other problems, expenses, difficulties, complications and
delays frequently encountered in connection with the formation of a new business
and the development and commercialization of new products, particularly
pharmaceutical and medical device products.

HISTORY OF LOSSES; UNCERTAINTY OF FUTURE PROFITABILITY

    The Company has generated little revenue to date, has experienced operating
losses since its inception in 1989 and has not yet achieved profitability. The
Company had an accumulated deficit of approximately $50.6 million (audited) and
$61.8 million (unaudited) as of December 31, 1996 and June 30, 1997,
respectively. These losses have resulted primarily from the Company's research
and development programs, the funding of preclinical and clinical testing and
regulatory activities and the general and administrative expenses associated
with these activities. The Company anticipates incurring substantial and
increasing losses over at least the next several years. The extent of losses and
the time required to reach profitability are highly uncertain. To achieve
sustained profitable operations, the Company, alone or with collaborative
partners, must successfully research, develop, test, obtain regulatory approval,
manufacture, introduce, market and distribute its products. There can be no
assurance that the Company will be able to achieve profitability or that
profitability, if achieved, can be sustained on an ongoing basis. Moreover, if
profitability is achieved, the level of that profitability cannot be accurately
predicted.

UNPROVEN SAFETY AND EFFICACY; CLINICAL TRIALS

    All drug and device products currently under development by the Company
will require extensive preclinical and clinical testing prior to regulatory
approval for commercial use. None of the Company's


                                          4
<PAGE>
products have completed testing for efficacy or safety in humans. There can be
no assurance that such testing will demonstrate that SnET2 or any other of the
Company's products is safe or efficacious or that testing for any of the
Company's compounds currently under development will be commenced or completed
successfully within any specified time period, if at all. Further, there can be
no assurance that clinical data reported by the Company will not change as a
result of the continuing evaluation of patients. Data obtained from preclinical
and clinical trials are subject to varying interpretations which can delay,
limit or prevent approval by the FDA or other regulatory authorities. There can
be no assurance that the Company will not encounter problems in research and
development, preclinical testing or clinical trials that will cause the Company
to delay, suspend or cancel clinical trials. Many potential pharmaceutical and
medical device products that achieve promising results in preclinical tests and
clinical trials fail to demonstrate sufficient safety or efficacy to warrant
approval by the FDA or other regulatory authorities, and there can be no
assurance that any of the Company's potential products will obtain the required
approvals or, if approved, will obtain sufficient market acceptance to become
commercially successful. Moreover, as a result of changing market, clinical or
regulatory conditions, or clinical trial results, the Company's focus may shift
to other indications, or it may be determined not to further pursue one or more
of the indications currently being pursued. 

    To date, the Company has very limited experience in conducting clinical
trials. The Company will either need to rely on third parties, including its
collaborative partners, to design and conduct any required clinical trials or
expend resources to hire additional personnel to administer such clinical
trials. There can be no assurance that the Company will be able to find
appropriate third parties to design and conduct clinical trials or that it will
have the resources to hire personnel to administer clinical trials in-house. 

RELIANCE ON COLLABORATIVE PARTNERS

    The Company has entered into collaborative relationships with certain 
corporations and academic institutions in connection with the research and 
development, preclinical and clinical testing, licensing, manufacturing and 
distribution of its products. In July 1995, the Company entered into a 
collaborative agreement with Pharmacia & Upjohn, Inc. pursuant to which the 
Company granted to Pharmacia & Upjohn an exclusive worldwide license to use, 
distribute and sell SnET2 for therapeutic or diagnostic applications in the 
area of photodynamic therapy. The amount of royalty revenues and other 
payments, if any, ultimately received by the Company with respect to sales of 
SnET2 is dependent, in part, on the amount and timing of resources Pharmacia 
& Upjohn commits to research and development, clinical testing and regulatory 
and marketing activities, which are entirely within the control of Pharmacia 
& Upjohn. The resources committed by Pharmacia & Upjohn in these areas will 
depend on Pharmacia & Upjohn's own competitive, marketing and strategic 
considerations, including the relative advantages of alternative products or 
therapies developed and marketed by Pharmacia & Upjohn or competitors. There 
can be no assurance that Pharmacia & Upjohn will pursue the development and 
commercialization of SnET2 or that Pharmacia & Upjohn will perform its 
obligations as expected. In addition, the Company is collaborating with 
Boston Scientific and Cordis with respect to the development of catheters for 
use in PhotoPoint, and with Medicis to develop and commercialize the 
Company's PhotoPoint technology for dermatology applications.  The Company 
has not entered into any definitive collaborative agreement with any of these 
three companies. No assurance can be given that these additional 
collaborations will culminate in definitive collaborative agreements or 
marketable products or will otherwise be successful. Also, the Company has 
entered into a device co-development and distribution agreement with Iridex 
in ophthalmology for PhotoPoint and a co-development agreement with Ramus in 
cardiology for PhotoPoint. There can be no assurance that Iridex and Ramus 
will continue to pursue the development of devices in the fields of  
ophthalmology for PhotoPoint and cardiology, respectively, or that such 
development will result in marketable products. 

    In addition, the Company is currently at various stages of discussions with
other companies regarding the establishment of various collaborations. The
Company's current and future collaborations are important because they allow the
Company greater access to funds, research, development or testing resources and
to manufacturing, sales or distribution resources than it would otherwise have,
and the Company intends to continue to rely on such collaborative arrangements.
However, there can be no assurance that the Company will be able to negotiate
acceptable collaborative arrangements in the future or that such future or
existing collaborative arrangements will be successful or result in products
that are marketed or sold. In addition, there can be no assurance that such
collaborative relationships will not limit or restrict the Company in any way.
Further, there can be no assurance that the Company's collaborative partners
will not develop or pursue alternative technologies either on their own or in
collaboration with others, including the Company's competitors, as a means of
developing or marketing products for the diseases targeted by the collaborative
programs and the Company's products. 


                                          5
<PAGE>

ADDITIONAL FINANCING REQUIREMENTS AND UNCERTAINTY OF CAPITAL FUNDING

    The Company has incurred negative cash flows from operations since its
inception and has expended substantial funds in connection with its research and
development programs and preclinical and clinical testing. The Company may
require substantial funding in the future to continue or undertake its research
and development activities, preclinical and clinical testing and manufacturing,
marketing, sales, distribution and administrative activities or to pursue
acquisition opportunities. There can be no assurance that the Company's existing
capital resources, together with the proceeds from future offerings and future
cash flows, will be sufficient to fund the Company's future operations. 

COMPETITION AND TECHNOLOGICAL UNCERTAINTY

    Many of the Company's competitors have substantially greater financial,
technical and human resources than the Company and substantially greater
experience in developing products, conducting preclinical or clinical testing,
obtaining regulatory approvals and manufacturing and marketing. Further, the
Company's competitive position could be materially adversely affected by the
establishment of patent protection by its competitors. There can be no assurance
that the Company's existing competitors or other companies will not succeed in
developing technologies and products that are more effective or affordable than
those being developed by the Company or that would render the Company's
technology and products less competitive or obsolete.

    The Company's products are subject to the risks of failure inherent in the
development and testing of products based on innovative technologies. These
risks include the possibilities that this technology or any or all of the
Company's products may be found to be ineffective or to have unanticipated
limitations or otherwise fail. 

GOVERNMENT REGULATION

    The production and marketing of the Company's products and its ongoing
research and development, preclinical testing and clinical trial activities are
subject to extensive regulation and review by numerous governmental authorities
in the United States, including the U.S. Food and Drug Administration (the
"FDA"), and in other countries. All drugs and most medical devices developed by
the Company must undergo rigorous preclinical and clinical testing and an
extensive regulatory approval process administered by the FDA under the Food,
Drug and Cosmetic Act, and comparable foreign authorities before they can be
marketed. These processes involve substantial cost and can take many years. The
Company has limited experience in, and limited resources available to commit to,
regulatory activities. Failure to comply with the applicable regulatory
requirements can, among other things, result in non-approval, suspensions of
regulatory approvals, fines, product seizures and recalls, operating
restrictions, injunctions and criminal prosecution.


    The time required for completing such testing and obtaining such approvals
is uncertain and approval itself may not be obtained. In addition, delays or
rejections may be encountered due to, among other reasons, regulatory review of
each submitted new drug, device or combination drug/device application or
product license application, as well as changes in regulatory policy during the
period of product development. Similar delays may also be encountered in foreign
countries. To date, no pharmaceutical product candidate being developed by the
Company has been submitted for approval or has been approved by the FDA or any
other regulatory authority for marketing, and there can be no assurance that,
even after investing substantial time and expense, regulatory approval will be
obtained for any products developed by the Company. Moreover, if regulatory
approval of a product is granted, such approval may entail limitations on the
indicated uses for which the product may be marketed. Further, even if such
regulatory approval is obtained, a marketed product, its manufacturer and the
facilities in which the product is manufactured are subject to continual review
and periodic inspections. Later discovery of previously unknown problems with a
product, manufacturer or facility may result in restrictions on such product or
manufacturer, including withdrawal of the product from the market and
litigation. Although to date photodynamic therapy products have been categorized
by the FDA as combination drug-device products, there can be no assurance that
the Company's products currently under investigation or any future drug/device
products will continue to be categorized for regulatory purposes as combination
products, that they will not require separate drug and device submissions, or
that they will not require separate approval by regulatory authorities. 

REIMBURSEMENT

    The Company's ability to commercialize its products successfully may depend
in part on the extent to which reimbursement for such products and related
treatment will be available from corporate partners, government health
administration authorities, private health insurers, managed care entities and
other


                                          6
<PAGE>

organizations. Such payors are increasingly challenging the price of medical
products and services and establishing protocols and formularies which
effectively limit physicians' ability to select products and procedures.
Uncertainty exists as to the reimbursement status of health care products
(especially innovative technologies), and there can be no assurance that
adequate reimbursement coverage will be available to enable the Company to
achieve market acceptance of its products or to maintain price levels sufficient
for realization of an appropriate return on its products. 

LIMITED MANUFACTURING AND MARKETING CAPABILITY AND EXPERIENCE

    To be successful, the Company's products must be manufactured in commercial
quantities under current Good Manufacturing Practices regulations ("GMP")
prescribed by the FDA and at acceptable costs. Although the Company intends to
manufacture drugs and devices, the Company has not yet manufactured any products
in commercial quantities under GMP and has no experience in such commercial
manufacturing.  Miravant Systems, Inc. has achieved registration to ISO 9001 and
EN 46001 quality standards of the European Community;  however, there is no
assurance that this subsidiary of the Company will be able to maintain these
registrations, nor that the registrations will facilitate the marketing of the
medical devices in Europe. The Company will need to expand its manufacturing
capabilities and/or depend on its collaborators, licensees or contract
manufacturers for the commercial manufacture of its products. In the event the
Company determines to expand its manufacturing capabilities, it will require the
expenditure of substantial funds, the hiring and retention of significant
additional personnel and compliance with extensive regulations applicable to
such expansion. There can be no assurance that the Company will be able to
expand such capabilities successfully or that it will be able to manufacture
products in commercial quantities for sale at competitive prices. Further, there
can be no assurance that the Company will be able to enter into manufacturing
arrangements with collaborators, licensees, or contract manufacturers on
acceptable terms or at all. If the Company is not able to expand its
manufacturing capabilities or enter into additional commercial manufacturing
agreements, it could be materially and adversely affected. 

    The Company has limited experience in marketing, distributing and selling
pharmaceutical products, and will need to develop a sales force or rely on its
collaborators or licensees or make arrangements with others to provide for the
marketing, distribution and sale of its products. There can be no assurance that
the Company's marketing, distribution and sales capabilities or current or
future arrangements with third parties to perform such activities will be
adequate for the successful commercialization of its products. 

UNCERTAINTY REGARDING PATENTS AND PROPRIETARY TECHNOLOGY

    The Company's success will depend, in part, on its and its licensors'
ability to obtain, assert and defend its patents, protect trade secrets and
operate without infringing the proprietary rights of others. The Company has
filed applications for or has been issued U.S. and foreign patents a majority of
which relate to its light delivery and measurement devices, and the Company has
an exclusive license under patent applications or patents of others relating to
certain photoreactive compounds.  Such issued U.S. patents expire from 2006
through 2014. Certain of the foregoing patents and patent applications are
subject to certain governmental rights. The exclusive license to the Company
under various drug patents, including patents relating to its leading drug
candidate SnET2, provides that the licensors may elect that the license become
non-exclusive if the Company fails to satisfy certain development and
commercialization objectives.  Although the Company believes it should be able
to achieve such objectives, there can be no assurance that the Company will be
successful. The patent position of pharmaceutical and medical device firms
generally is highly uncertain and involves complex legal and factual questions.
There can be no assurance that the patent applications owned by or licensed to
the Company will result in issued patents, that any issued patents will provide
the Company with proprietary protection or competitive advantages, will not be
infringed upon or designed around by others, will not be challenged by others
and held to be invalid or unenforceable or that the patents of others will not
have a material adverse effect on the Company.

    The Company is aware that its competitors and other companies, institutions
and individuals have been issued patents relating to photodynamic therapy. In
addition, the Company's competitors and other companies, institutions and
individuals may have filed patent applications or been issued patents relating
to other potentially competitive products of which the Company is not aware.
Further, the Company's competitors and other companies, institutions and
individuals may in the future file applications for, or be granted or license or
otherwise obtain proprietary rights to, patents relating to other potentially
competitive products. There can be no assurance that these existing or future
patents or patent applications will not conflict with the Company's or its
licensors' patents or patent applications. Such conflicts could result in a
rejection of the Company's or its


                                          7
<PAGE>

licensors' patent applications or the invalidation of their patents, which could
have a material adverse effect on the Company's competitive position. In the
event of such conflicts, or in the event the Company believes that such
competitive products may infringe the patents owned by or licensed to the
Company, the Company may pursue patent infringement litigation or interference
proceedings against, or may be required to defend against litigation involving,
holders of such conflicting patents or competing products. Such proceedings may
materially adversely affect the Company's competitive position, and there can be
no assurance that the Company will be successful in any such proceeding.
Litigation and other proceedings relating to patent matters, whether initiated
by the Company or a third party, can be expensive and time consuming, regardless
of whether the outcome is favorable to the Company, and can result in the
diversion of substantial financial, managerial and other resources from the
Company's other activities. An adverse outcome could subject the Company to
significant liabilities to third parties or require the Company to cease any
related research and development activities or product sales. The Company does
not have contractual indemnification rights against the licensors of the various
drug patents. In addition, if patents that contain dominating or conflicting
claims have been or are subsequently issued to others and such claims are
ultimately determined to be valid, the Company may be required to obtain
licenses under patents or other proprietary rights of others. No assurance can
be given that any licenses required under any such patents or proprietary rights
would be made available on terms acceptable to the Company, if at all. If the
Company does not obtain such licenses, it could encounter delays or could find
that the development, manufacture or sale of products requiring such licenses is
foreclosed. 

    The Company also seeks to protect its proprietary technology and processes
in part by confidentiality agreements with its collaborative partners, employees
and consultants. There can be no assurance that these agreements will not be
breached, that the Company will have adequate remedies for any breach, or that
the Company's trade secrets will not otherwise become known or be independently
discovered by competitors. Certain of the research activities relating to the
development of certain of the patents owned by or licensed to the Company were
funded, in part, by agencies of the United States government. When the United
States government participates in research activities, it retains certain rights
that include the right to use the resulting patents for government purposes
under a royalty-free license.

DEPENDENCE UPON KEY PERSONNEL AND CONSULTANTS

    The Company's ability to successfully develop its products, manage growth
and maintain a competitive position will depend in large part on its ability to
attract and retain highly qualified scientific, management and other personnel
and to develop and maintain relationships with leading research institutions and
consultants. The Company is highly dependent upon principal members of its
management, key employees, scientific staff and consultants which the Company
may retain from time to time. Competition for such personnel and relationships
is intense, and there can be no assurance that the Company will be able to
continue to attract and retain such personnel. The Company's consultants may be
affiliated or employed by others, and some have consulting or other advisory
arrangements with other entities that may conflict or compete with their
obligations to the Company. Inventions or processes discovered by such persons
will not necessarily become the property of the Company and may remain the
property of such persons or others. 

DEPENDENCE UPON SUPPLIERS

    The Company currently depends upon outside suppliers, contracted or
otherwise, for certain raw materials and components for its products. There can
be no assurance that such raw materials or components will continue to be
available to the Company's standards or on acceptable terms, if at all, or that
alternative suppliers will be available to the Company on acceptable terms, if
at all. Further, there can be no assurance that the Company will be able to
produce needed materials or components in-house in a timely manner or in
sufficient quantities to meet the needs of the Company, if at all. Although most
of the Company's raw materials and components are available from various
sources, the Company is currently dependent on single, contracted sources for
certain key materials or services used by the Company in its drug development,
light producing and light delivery device development  and production
operations. Although the Company has entered into agreements with these
suppliers, there can be no assurance that these arrangements will be successful
or that the Company will not encounter delays or other problems which may
materially adversely affect its business. 

ENVIRONMENTAL MATTERS

    The Company is subject to federal, state, county and local laws and
regulations relating to the protection of the environment. In the course of its
business, the Company is involved in the handling, storage and disposal of
materials that are classified as hazardous. The Company's safety procedures for
handling, storage and disposal


                                          8
<PAGE>

of such materials are designed to comply with the standards prescribed by
applicable laws and regulations. However, there can be no assurance that the
Company will not be involved in contamination or injury from these materials. In
the event of such an occurrence, the Company could be held liable for any
damages that result, and any such liability could materially and adversely
affect the Company. Further, there can be no assurance that the cost of
complying with these laws and regulations will not increase materially in the
future.

CONTROL BY OFFICERS AND DIRECTORS
   
    As of November 24, 1997, the Company's officers and directors beneficially
own approximately 18.4% of the outstanding Common Stock (approximately 27.5% is
beneficially owned if all options granted to such officers and directors become
vested and are exercised). These shareholders will be able to elect a
substantial number of the Company's directors and will have the ability to
influence significantly the Company and the direction of its business and
affairs. Such concentration of ownership may have the effect of delaying or
preventing a change in control of the Company, which could adversely affect the
market price for the Common Stock.
    
OUTSTANDING OPTIONS AND WARRANTS 
   
    As of November 24, 1997, there were outstanding options to purchase
2,148,609 shares of Common Stock at a weighted average exercise price of $15.40
per share, and warrants to purchase 3,122,677 shares of Common Stock at a
weighted average exercise price of $36.43 per share.  The exercise of these
options and warrants would result in significant book value and earnings
dilution to existing shareholders. 
    
LIABILITY AND RECALL EXPOSURE

    The use of the Company's products in clinical trials and the sale of such
products may expose the Company to liability claims. These claims could be made
directly by patients or consumers or by companies, institutions or others using
or selling such products. In addition, the Company is subject to the inherent
risk that a government authority or third party may require the recall of one or
more of the Company's products. The Company has not obtained liability insurance
that would cover a claim relating to the use or recall of its products. In the
absence of such insurance, claims made against the Company or a product recall
could have a material adverse effect on the Company. In addition, there can be
no assurance that, if the Company seeks insurance coverage in the future, such
coverage will be available at all or, if available, at reasonable cost and in
amounts sufficient to protect the Company against claims that could have a
material adverse effect on the financial condition and prospects of the Company.
Further, liability claims relating to the use of the Company's products or a
product recall could negatively affect the Company's ability to obtain or
maintain regulatory approvals for its products. The Company has agreed to
indemnify certain of its collaborative partners against certain potential
liabilities relating to the manufacture and sale of SnET2 and PhotoPoint light
devices. 

POSSIBLE ADVERSE EFFECTS OF FUTURE LEGISLATION OR REGULATIONS

    Heightened public awareness and concerns regarding the growth in overall
health care expenditures in the United States, combined with the continuing
efforts of governmental authorities to contain or reduce costs of health care,
may result in the enactment of national health care reform or other legislation
or regulations that impose limits on the number and type of medical procedures
which may be performed or which have the effect of restricting a physician's
ability to select specific products for use in certain procedures. Such new
legislation or regulations may materially adversely affect the demand for the
Company's products. In the United States, there have been, and the Company
expects that there will continue to be, a number of federal and state
legislative proposals and regulations to implement greater governmental control
in the health care industry. For example, the Clinton Administration and certain
members of Congress have proposed health care reform legislation that may impose
pricing or profitability limitations or other restrictions on companies in the
health care industry. The announcement of such proposals may materially
adversely affect the Company's ability to raise capital or to form
collaborations, and the enactment of any such reforms could have a material
adverse effect on the Company. In certain foreign markets, the pricing and
profitability of health care products are subject to governmental influence or
control. In addition, legislation or regulations that impose restrictions on the
price that may be charged for health care products or medical devices may
adversely affect the Company's results of operations. From time to time,
legislation or regulatory proposals are considered that could alter the review
and approval process relating to pharmaceutical or medical device products. The
Company is unable to predict the likelihood of adverse effects which might arise
from future legislative or administrative action, either in the United States or
abroad.


                                          9
<PAGE>


SHARES ELIGIBLE FOR FUTURE SALE

    Sales of Common Stock in the public market following this offering,
pursuant to Rule 144 under the Securities Act, or upon the exercise of
outstanding options or warrants under Rule 701 or pursuant to the Company's
Registration Statements on Form S-8, could materially adversely affect
prevailing market prices and may have a material and adverse effect on the
Company's ability to raise the capital necessary to fund its future operations. 
Additionally, certain holders of shares of Common Stock are entitled to have
their shares registered for sale under the Securities Act by the Company under
certain circumstances. The exercise of these rights and the sale of such shares
could have a material adverse effect on the market price for the Common Stock.

POTENTIAL VOLATILITY OF STOCK PRICE; NO DIVIDENDS

    The market prices for securities of emerging pharmaceutical and medical
device companies have historically been highly volatile. Future announcements
concerning the Company or its collaborators, competitors or industry, including
but not limited to the results of testing, technological innovations or new
commercial products, the achievement of or failure to achieve certain
milestones, governmental regulations, rules and orders, developments concerning
patents or other proprietary rights, litigation or public concern about the
safety of the Company's products, may have a material adverse effect on the
market price of the Common Stock. In addition, the stock market has experienced
extreme price and volume fluctuations. This volatility has significantly
affected the market prices of securities of many emerging pharmaceutical and
medical device companies for reasons frequently unrelated or disproportionate to
the performance of the specific companies. These broad market fluctuations may
materially adversely affect the market price of the Common Stock.  Except for
the three for two split of the Common Stock declared for stockholders of record
at July 24, 1995, the Company has never paid dividends, cash or otherwise, on
its capital stock and does not anticipate paying any such dividends in the
foreseeable future. The Company's bank credit line prohibits the payment of
dividends on its Common Stock. 


PRICE PROTECTION PROVISIONS OF  SECURITIES PURCHASE AGREEMENTS

    The Securities Purchase Agreements relating to the sales by the Company to
the Selling Shareholders of the Shares offered hereby (the "Securities Purchase
Agreements") provide that if on the first anniversary of the closing of such
purchases, the 30 day average closing bid price of the Common Stock for the
period ending on the trading day prior to the anniversary date is less than the
closing price paid by the Selling Shareholders, then the Company shall pay each
Selling Shareholder additional cash or stock, or a combination of both, as
determined by the Company at its sole option.  In the event that the price of
the Common Stock is significantly below the closing price at the anniversary
date, such payment, if made in cash, would have a material adverse impact on the
liquidity and financial condition of the Company, or would, if made in shares of
Common Stock, result in dilution to existing shareholders.


                                          10
<PAGE>

                               USE OF PROCEEDS

    The Company will receive none of the proceeds from the sale of the Shares
by the Selling Shareholders, but will receive the exercise prices payable upon
the exercise of the Warrants, if exercised for cash.  Such proceeds will be used
for working capital and general corporate purposes.


                             SELLING SHAREHOLDERS
   
    The following table sets forth information with respect to the number of
Shares beneficially owned by each of the Selling Shareholders, the  number of
Shares that may be offered hereby by each Selling Shareholder and the number of
shares of Common Stock to be owned after the offering, assuming all the Shares
offered hereby are sold to persons not affiliated with the Selling Shareholders.
None of the Selling Shareholders has, or in the past has had, any position,
office or relationship with the Company (other than as a security holder) or any
of its affiliates.  As of November 24, 1997 there were 14,045,983 shares of
Common Stock issued and outstanding.
    

<TABLE>
<CAPTION>

                                            Number of
                                       Shares Beneficially        Number of                  Number of
                                         Owned Prior To            Shares                   Shares Owned
         Name                            Offering(1)(2)         Being Offered(1)(2)      After The Offering
- -------------------------------------- ------------------       -------------------      ------------------
<S>                                    <C>                      <C>                      <C>
Elliott Associates, L.P.                    400,000                400,000                       0
Westgate International, L.P.                400,000                400,000                       0
Shepard Investments International, Ltd.     474,000                474,000                       0
Stark International                         474,000                474,000                       0
Staro Partners                               52,000                 52,000                       0
St. Cloud Investments, Ltd.                 333,334                333,334                       0
Bomoseen Investments, Ltd.                  331,334                331,334                       0
Dandelion Investments, Ltd.                 333,332                333,332                       0
Stanley Arkin                                 2,000                  2,000                       0
Bayview Investors, Ltd.                      32,000                 32,000                       0
                                            -------                -------                       -
                                          2,832,000              2,832,000                       0

</TABLE>

(1) Such shares are subject to a Lock-Up Agreement prohibiting any offer or 
    sale until September 22, 1998 with respect to the first nine Selling 
    Shareholders set forth above and until October 16, 1998 with respect to 
    the last Selling Shareholder. The Lock-Up Agreement is subject to earlier 
    termination in certain limited circumstances, and the prohibition on sales 
    is subject to certain limited exceptions.

   
(2) With respect to each Selling Shareholder, 50% of the amounts shown 
    represent Shares issuable upon the exercise of the Warrants (the "Warrant 
    Shares").  Of such Warrant Shares, 50% are exercisable at $55 per share 
    and 50% are exercisable at $60 per share.  708,000 Shares that may become 
    issuable pursuant to the anti-dilution provisions of the Warrants, as 
    such number may be adjusted in accordance with Rule 416, or the price 
    protection provisions of Section 5.3 of the Securities Purchase 
    Agreement, may also be offered hereby. See "Risk Factors - Price 
    Protection Provisions of Securities Purchase Agreements." The 
    Registration Rights Agreements among the Company and the Selling 
    Shareholders require the Company to register an amount equal to 125% of 
    the Shares (including Shares issuable upon exercise of the Warrants) held 
    by the Selling Shareholders.
    

                                          11
<PAGE>

                                 PLAN OF DISTRIBUTION

    The Shares may be sold from time to time by the Selling Shareholders or
their pledgees or donees, subject to the Lock-Up Agreement described above.  See
"Selling Shareholders."  Such sales may be made on the NNM or in negotiated
transactions, at prices and on terms then prevailing or at prices related to the
then current market price or at negotiated prices.  The methods by which the
Shares may be sold may include, but not be limited to, the following:  (a) block
trades in which the broker or dealer will attempt to sell the Shares as agent
but may position and resell a portion of the block as principal to facilitate
the transaction; (b) purchases by a broker or dealer as principal and resale by
such broker or dealer for its account; (c) ordinary brokerage transactions and
transactions in which the broker solicits purchasers; (d) privately negotiated
transactions; (e) short sales; and (f) a combination of any such methods of
sale.  In effecting sales, brokers or dealers engaged by the Selling
Shareholders may receive commissions or discounts from the Selling Shareholders
or from the purchasers in amounts to be negotiated immediately prior to the
sale.

    The Company has agreed to maintain the effectiveness of the registration of
the Shares offered hereby until the earlier of the date upon which all of the
Shares offered hereby have been sold without restriction on resale, or the date
on which the Shares offered hereby, in the opinion of counsel, may be
immediately sold by the Selling Shareholders without registration or restriction
on resale.  There can be no assurance that the Selling Shareholders will sell
any or all of the Shares offered hereby.

    The Company is bearing all of the costs relating to the registration of the
Shares.  Any commissions, discounts or other fees payable to a broker, dealer,
underwriter, agent or market maker in connection with the sale of any of the
Shares will be borne by the Selling Shareholders.  The Company will not receive
any of the proceeds from this offering, but will receive the exercise price
payable upon the exercise of the Warrants if the Warrants are exercised for
cash.

    Pursuant to the registration rights granted to the Selling Shareholders in
connection with the sale by the Company of the Shares, the Company has agreed to
indemnify the Selling Shareholders, any person who controls a Selling
Shareholder, and any underwriters for the Selling Shareholders, against certain
liabilities and expenses arising out of or based upon the information set forth
or incorporated by reference in this Prospectus, and the Registration Statement
of which this Prospectus is a part, including liabilities under the Securities
Act and the Exchange Act.  The Selling Shareholders and any brokers
participating in such sales may be deemed to be underwriters within the meaning
of the Securities Act.  Any commissions paid or any discounts or concessions
allowed to any broker, dealer, underwriter, agent or market maker and, if any
such broker, dealer, underwriter, agent or market maker purchases any of the
Shares as principal, any profits received on the resale of such Shares, may be
deemed to be underwriting commissions or discounts under the Securities Act. 

                                    LEGAL MATTERS

    The validity of the issuance of the Shares of Common Stock offered hereby
has been passed upon for the Company by Nida & Maloney, a Professional
Corporation, Santa Barbara, California. 

                                       EXPERTS

    The consolidated financial statements of Miravant Medical Technologies and
subsidiaries at December 31, 1996 and 1995, and for each of the three years in
the period ended December 31, 1996 incorporated by reference in this Prospectus
and Registration Statement have been audited by Ernst & Young LLP, independent
auditors, as set forth in their report thereon, and are included in reliance
upon such report given upon the authority of such firm as experts in accounting
and auditing. 


                                          12
<PAGE>

                                       PART II.
                      INFORMATION NOT REQUIRED IN THE PROSPECTUS

ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.

    The following table sets forth the estimated expenses to be incurred in
connection with the issuance and distribution of the securities being registered
hereby:

         SEC registration fee. . . . . . . . . . . . .   $ 60,072.73
         Nasdaq National Market listing fee. . . . . .        17,500
         Accounting fees and expenses. . . . . . . . .        10,000
         Legal fees and expenses . . . . . . . . . . .        30,000
         Printing expenses . . . . . . . . . . . . . .        10,000
         Miscellaneous . . . . . . . . . . . . . . . .         5,000
                                                            --------

                   TOTAL . . . . . . . . . . . . . . .   $132,572.73
                                                          ----------
                                                          ----------

ITEM 15. INDEMNIFICATION OF DIRECTORS AND OFFICERS.

    Section 102(b)(7) of the Delaware General Corporation Law (the "Delaware
Law") permits a corporation to provide in its certificate of incorporation that
directors of the corporation shall not be personally liable to the corporation
or its shareholders for monetary damages for breach of fiduciary duty as a
director, except for liability (i) for any breach of the director's duty of
loyalty to the corporation or its shareholders, (ii) for acts or omissions not
in good faith or which involve intentional misconduct or a knowing violation of
law, (iii) for payments of unlawful dividends or unlawful stock repurchases or
redemptions, or (iv) for any transaction from which the director derived an
improper personal benefit.  The Company's Certificate of Incorporation contains
such a provision.

    Section 145 of the Delaware Law provides that a corporation may indemnify
directors and officers as well as other employees and individuals against
expenses (including attorneys' fees), judgments, fines and amounts paid in
settlement in connection with specified actions, suits or proceedings, whether
civil, criminal, administrative or investigative (other than an action by or in
the right of the corporation - a "derivative action"), if they acted in good
faith and in a manner they reasonably believed to be in or not opposed to the
best interests of the corporation, and, with respect to any criminal action or
proceeding, had no reasonable cause to believe their conduct was unlawful.  A
similar standard is applicable in the case of derivative actions, except that
indemnification only extends to expenses (including attorneys' fees) incurred in
connection with defense or settlement of such action, and the statute requires
court approval before there can be any indemnification where the person seeking
indemnification has been found liable to the corporation.  Under Section 145, a
corporation shall indemnify an agent of the corporation for expenses actually
and reasonably incurred if and to the extent such person was successful on the
merits in a proceeding or in defense of any claim, issue or matter therein.

    The Registrant is presently subject to Section 2115 of the California
Corporations Code (the "California Code"), according to which Section 317 of the
California Code applies to the indemnification of officers and directors of the
Registrant.  Under Section 317 of the California Code, permissible
indemnification by a corporation of its officers and directors is substantially
the same as permissible indemnification under Section 145 of the Delaware Law,
except that (i) permissible indemnification does not cover actions the person
reasonably believed were not opposed to the best interests of the corporation,
as opposed to those the person believed were in fact in the best interests of
the corporation, (ii) the Delaware Law permits advancement of expenses to agents
other than officers and directors only upon approval of the board of directors,
(iii) in a case of stockholder approval of indemnification, the California Code
requires certain minimum votes in favor of such indemnification and excludes the
vote of the potentially indemnified person, and (iv) the California Code only
permits independent counsel to approve indemnification if an independent quorum
of directors is not obtainable, while the Delaware Law permits the directors in
any circumstance to appoint counsel to undertake such determination.


                                         II-1
<PAGE>

    The Registrant in its Bylaws has provided for indemnification of its
officers, directors, employees and other agents substantially identical to that
permitted under the California Code.  Section 145 of the Delaware Law and
Section 317 of the California Code provide that they are not exclusive of other
indemnification that may be granted by a corporation's charter, bylaws,
disinterested director vote, shareholder vote, agreement or otherwise.  The
limitation of liability contained in the Registrant's Certificate of
Incorporation and the indemnification provision included in the Registrant's
Bylaws are consistent with Delaware Law Sections 102(b)(7) and 145.  The
Registrant has also entered into separate indemnification agreements with its
directors and officers that could require the Registrant, among other things, to
indemnify them against certain liabilities that may arise by reason of their
status or service as directors and officers and to advance their expenses
incurred as a result of any proceeding against them as to which they could be
indemnified, including liabilities that may arise under the Securities Act of
1933.  In addition, the Company has purchased directors and officers insurance.

    Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers or persons controlling the
Company pursuant to such provisions, the Company has been informed that in the
opinion of the Securities and Exchange Commission such indemnification is
against public policy as expressed in such Act and is therefore unenforceable.

ITEM 16.  EXHIBITS.


Exhibit
Number
- -------
   
4.1      Form of $55 Common Stock Purchase Warrant issued to the Selling
         Shareholders(1)
4.2      Form of $60 Common Stock Purchase Warrant issued to the Selling
         Shareholders(1)
5.1      Opinion of Nida & Maloney, a Professional Corporation(1)
10.1     Form of Securities Purchase Agreement among the Company and the
         Selling Shareholders
10.2     Form of Lock-Up Agreement among the Company and the Selling
         Shareholders
10.3     Form of Registration Rights Agreement among the Company and the
         Selling Shareholders(1)
23.1     Consent of Ernst & Young LLP
23.2     Consent of Nida & Maloney, a Professional Corporation (included in
         Exhibit 5.1)(1)
24       Power of Attorney (set forth on Page II-4)(1)

(1)   Previously filed.
    

ITEM 17. UNDERTAKINGS.

(a)  The undersigned Registrant hereby undertakes:

    (1)  To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement:

         (i)  To include any prospectus required by Section 10(a)(3) of the
Securities Act of 1933;

         (ii) To reflect in the prospectus any facts or events arising after
the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate,
represent a fundamental change in the information set forth in the registration
statement;

         (iii) To include any material information with respect to the plan of
distribution not previously disclosed in the registration statement or any
material change to such information in the registration statement;

         Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed by the Registrant
pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934
that are incorporated by reference in the registration statement.


                                         II-2
<PAGE>

    (2)  That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial BONA
FIDE offering thereof.

    (3)  To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of the
offering.

(b)  That, for purposes of determining any liability under the Securities Act of
1933, each filing of the Registrant's annual report pursuant to Section 13(a) or
Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable,
each filing of an employee benefit plan's annual report pursuant to Section
15(d) of the Securities Exchange Act of 1934) that is incorporated by reference
in the registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial BONA FIDE offering thereof.

(c)  Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities Act
of 1933 and is, therefore, unenforceable.  In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act of 1933 and will be governed by the final adjudication of such issue.


                                         II-3
<PAGE>

                                      SIGNATURES
   
    PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THE REGISTRANT
CERTIFIES THAT IT HAS REASONABLE GROUNDS TO BELIEVE THAT IT MEETS ALL OF THE
REQUIREMENTS FOR FILING ON FORM S-3 AND HAS DULY CAUSED THIS REGISTRATION
STATEMENT TO BE SIGNED ON ITS BEHALF BY THE UNDERSIGNED, THEREUNTO DULY
AUTHORIZED, IN THE CITY OF SANTA BARBARA, STATE OF CALIFORNIA, ON
DECEMBER 4, 1997.
    

                        MIRAVANT MEDICAL TECHNOLOGIES

                        By:  /S/  Gary S. Kledzik
                           ---------------------------------------------------
                                  Gary S. Kledzik, Ph.D., Chief Executive
                                  Officer

   
    

    PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THIS
REGISTRATION STATEMENT HAS BEEN SIGNED BY THE FOLLOWING PERSONS IN THE
CAPACITIES AND ON THE DATES INDICATED.
   
<TABLE>
<CAPTION>
         SIGNATURE                               TITLE                                   DATE
         ---------                               -----                                   ----
<S>                                    <C>                                          <C>
/S/    Gary S. Kledzik                 Chairman of the Board, Director,             DECEMBER 4, 1997
- ----------------------------           and Chief Executive Officer
      Gary S. Kledzik                  (principal executive officer)

/S/    David E. Mai*                   Director and President                       DECEMBER 4, 1997
- ----------------------------
      David E. Mai

/S/   John M. Philpott*                Chief Financial Officer                      DECEMBER 4, 1997
- ----------------------------           (principal financial officer and
John M. Philpott                       principal accounting officer)


/S/  Michael D. Farney*                Director                                     DECEMBER 4, 1997
- ----------------------------
Michael D. Farney

/S/   Donald K. McGhan*                Director                                     DECEMBER 4, 1997
- ----------------------------
Donald K. McGhan

/S/    Raul E. Perez*                  Director                                     DECEMBER 4, 1997
- ----------------------------
Raul E. Perez, M.D.

/S/   Charles T. Foscue*               Director                                     DECEMBER 4, 1997
- ----------------------------
Charles T. Foscue

/S/   Jonah Shacknai*                   Director                                    DECEMBER 4, 1997
- ----------------------------
Jonah Shacknai

* By /s/ Gary S. Kledzik
- ----------------------------
     Gary S Kledzik
     Attorney-in-fact
</TABLE>
    
                                         II-4
<PAGE>

                                  INDEX TO EXHIBITS


                                                                   Sequentially
Exhibit                                                              Numbered
Number                       Exhibit                                   Page
- -------                      -------                                   ----
   
4.1      Form of $55 Common Stock Purchase Warrant issued to the
         Selling Shareholders(1)

4.2      Form of $60 Common Stock Purchase Warrant issued to the
         Selling Shareholders(1)

5.1      Opinion of Nida & Maloney, a Professional Corporation(1)

10.1     Form of Securities Purchase Agreement among the Company
         and the Selling Shareholders

10.2     Form of Lock-Up Agreement among the Company and the Selling
         Shareholders

10.3     Form of Registration Rights Agreement among the Company and
         the Selling Shareholders(1)

23.1     Consent of Ernst & Young LLP

23.2     Consent of Nida & Maloney, a Professional Corporation
         (included in Exhibit 5.1)(1)

24       Power of Attorney (set forth on Page II-4)(1)


(1) Previously filed.
    
                                         II-5

<PAGE>

                     SCHEDULE OF INFORMATION OMITTED FROM EXHIBITS

<TABLE>
<CAPTION>

EXHIBITS 4.1 AND 4.2--COMMON STOCK PURCHASE WARRANTS

          HOLDER'S NAME                   NUMBER OF $55.00 WARRANTS    NUMBER OF $60.00 WARRANTS   GRANT DATE    EXPIRATION DATE
          -------------                   -------------------------    -------------------------   ----------    ---------------
<S>                                       <C>                          <C>                         <C>
Elliott Associates, L.P.                          100,000                       100,000              9/25/97         12/25/01
Westgate International, L.P.                      100,000                       100,000              9/25/97         12/25/01
Shepard Investments International, Ltd.           118,500                       118,500              9/25/97         12/25/01
Stark International                               118,500                       118,500              9/25/97         12/25/01
Staro Partners                                     13,000                        13,000              9/25/97         12/25/01
St. Cloud Investments, Ltd.                        83,334                        83,333              10/3/97         12/25/01
Bomoseen Investments, Ltd.                         82,833                        82,834              10/3/97         12/25/01
Dandelion Investments, Ltd.                        83,333                        83,333              10/3/97         12/25/01
Stanley Arkin                                         500                           500              10/3/97         12/25/01
Bayview Investors, Ltd.                             8,000                         8,000             10/16/97         12/31/01

<CAPTION>

EXHIBIT 10.3-- SECURITIES PURCHASE AGREEMENT

                                                                        NUMBER OF
         PURCHASER'S NAME                       NUMBER OF SHARES         WARRANTS         DATE          SECTION 2.10   SECTION 4.5
         ----------------                       ----------------        ---------         ----          ------------   -----------
<S>                                            <C>                     <C>             <C>             <C>            <C>
Elliott Associates, L.P.                            200,000             200,000        9/22/97         $35,000,000        (1)
Westgate International, L.P.                        200,000             200,000        9/22/97         $35,000,000        (1)
Shepard Investments International, Ltd.             237,000             237,000        9/22/97         $35,000,000        (1)
Stark International                                 237,000             237,000        9/22/97         $35,000,000        (1)
Staro Partners                                       26,000              26,000        9/22/97         $35,000,000        (1)
St. Cloud Investments, Ltd.                         166,667             166,667        10/3/97         $10,000,000    $45,000,000
Bomoseen Investments, Ltd.                          166,667             165,667        10/3/97         $10,000,000    $45,000,000
Dandelion Investments, Ltd.                         166,666             166,666        10/3/97         $10,000,000    $45,000,000
Stanley Arkin                                         1,000               1,000        10/3/97         $10,000,000    $45,000,000
Bayview Investors, Ltd.                              16,000              16,000       10/16/97         $ 9,200,000    $70,000,000
</TABLE>

- -----------------------------------------------------
(1)  Bracketed text not included in these agreements.

<PAGE>

EXHIBIT 10.4-- LOCK-UP AGREEMENT

<TABLE>
<CAPTION>
            PURCHASER'S NAME                                    DATE                  LOCK-UP RELEASE DATE
            ----------------                                    ----                  --------------------
<S>                                                           <C>                    <C>
Elliott Associates, L.P.                                      9/22/97                       9/22/98
Westgate International, L.P.                                  9/22/97                       9/22/98
Shepard Investments International, Ltd.                       9/22/97                       9/22/98
Stark International                                           9/22/97                       9/22/98
Staro Partners                                                9/22/97                       9/22/98
St. Cloud Investments, Ltd.                                   10/3/97                       9/22/98
Bomoseen Investments, Ltd.                                    10/3/97                       9/22/98
Dandelion Investments, Ltd.                                   10/3/97                       9/22/98
Stanley Arkin                                                 10/3/97                       9/22/98
Bayview Investors, Ltd.                                      10/16/97                      10/16/98


EXHIBIT 10.5-- REGISTRATION RIGHTS AGREEMENT

            PURCHASER'S NAME                                    DATE                  NUMBER OF SHARES
            ----------------                                    ----                  ----------------

                  (2)                                            (2)                         (3)
</TABLE>

- ----------------------------------------
(2)  See Schedule to Exhibit 10.4
(3)  See Schedule to Exhibit 10.3

                                        

<PAGE>

SECURITIES  PURCHASE AGREEMENT

     This SECURITIES PURCHASE AGREEMENT ("Agreement") is entered into as of 
_______________, 1997, by and between MIRAVANT MEDICAL TECHNOLOGIES, a 
Delaware corporation (the "Company"), with headquarters located at 7408 
Hollister Avenue, Santa Barbara, California  93117 and the purchaser (the 
"Purchaser") set forth on the execution pages hereof, with regard to the 
following:

RECITALS

     A.   The Company and Purchaser are executing and delivering this 
Agreement in reliance upon the exemption from securities registration 
afforded by the provisions of Regulation D ("Regulation D"), as promulgated 
by the United States Securities and Exchange Commission (the "SEC") under the 
Securities Act of 1933, as amended (the "Securities Act").

     B.   Purchaser desires to (a) purchase, upon the terms and conditions 
stated in this Agreement, shares of the Company's Common Stock, par value 
$.01 per share (the "Common Stock"), and (b) to receive, in consideration for 
such purchase, Stock Purchase Warrants (the "Warrants"), in the form attached 
hereto as Exhibit A, to acquire shares of Common Stock. The shares of Common 
Stock issuable upon exercise of or otherwise pursuant to the Warrants are 
referred to herein as "Warrant Shares". The shares of Common Stock issued to 
the Purchaser hereunder (exclusive of the Warrant Shares) are referred to 
herein as the "Common Shares."  The Common Shares, the Warrants, and the 
Warrant Shares are collectively referred to herein as the "Securities."

     C.   Contemporaneously with the execution and delivery of this 
Agreement, the parties hereto are executing and delivering a Registration 
Rights Agreement in the form attached hereto as Exhibit B (the "Registration 
Rights Agreement"), pursuant to which the Company has agreed to provide 
certain registration rights under the Securities Act, the rules and 
regulations promulgated thereunder and applicable state securities laws.

     D.   Contemporaneously with the execution and delivery of this 
Agreement, the parties hereto are executing and delivering a Lock-Up 
Agreement in the form attached hereto as Exhibit C (the "Lock-Up Agreement"), 
pursuant to which each Purchaser has agreed to limit the disposition of the 
Common Shares purchased by it hereunder in accordance with the terms 
specified in such agreement, as well as the Warrant Shares.

AGREEMENTS

     NOW, THEREFORE, in consideration of their respective promises contained 
herein and other good and valuable consideration, the receipt and sufficiency 
of which are hereby acknowledged, the Company and Purchaser hereby agree as 
follows:

ARTICLE I
PURCHASE AND SALE OF COMMON STOCK

     1.1  Purchase of Common Stock.  Subject to the terms and conditions of 
this Agreement, the issuance, sale and purchase of the Common Shares shall be 
consummated in a "Closing". The purchase price (the "Purchase Price") per 
share of Common Stock shall be $50.00.  On the date of the Closing, subject 
to the satisfaction or waiver of the conditions set forth in Articles VI and 
VII, the Company shall issue and sell to each Purchaser, and each Purchaser 
severally agrees to purchase from the Company, the number of shares of Common 
Stock set forth on the signature page executed by such Purchaser. Each 
Purchaser's obligation to purchase Common Shares hereunder is distinct and 
separate from each other 


<PAGE>

Purchaser's obligation to purchase, and no Purchaser shall be required to 
purchase hereunder more than the number of Common Shares set forth on such 
Purchaser's signature page. The obligations of the Company with respect to 
each Purchaser shall be separate from the obligations of each other Purchaser 
and shall not be conditioned as to any Purchaser upon the performance of 
obligations of any other Purchaser.

     1.2  Form of Payment.  Each Purchaser shall pay the aggregate Purchase 
Price for the Common Shares being purchased by such Purchaser by wire 
transfer to the account designated by the Company.

     1.3  Closing Date.  Subject to the satisfaction (or waiver) of the 
conditions set forth in Articles VI and VII below, the date and time of the 
issuance, sale and purchase of the Common Shares and Warrants pursuant to 
this Agreement shall be at 10:00 a.m. California time, on ____________, 1997.

     1.4  Warrants.  In consideration of the purchase by Purchaser of the 
Common Shares, the Company shall at the Closing issue to each Purchaser, in 
the aggregate, Warrants to acquire, for each One Thousand (1,000) Common 
Shares purchased by such Purchaser hereunder, (a) Five Hundred (500) shares 
of Common Stock at an exercise price of $55.00 per share of Common Stock and 
(b) Five Hundred (500) shares of Common Stock at an exercise price of $60.00 
per share of Common Stock.

ARTICLE II
PURCHASER'S REPRESENTATIONS AND
WARRANTIES

     Each Purchaser represents and warrants as of the date hereof and as of 
the Closing, severally and solely with respect to itself and its purchase 
hereunder and not with respect to any other Purchaser or the purchase 
hereunder by any other Purchaser (and no Purchaser shall be deemed to make or 
have any liability for any representation or warranty made by any other 
Purchaser), to the Company as set forth in this Article II.  No Purchaser 
makes any other representations or warranties, express or implied, to the 
Company in connection with the transactions contemplated hereby and any and 
all prior representations and warranties, if any, which may have been made by 
a Purchaser to the Company in connection with the transactions contemplated 
hereby shall be deemed to have been merged in this Agreement and any such 
prior representations and warranties, if any, shall not survive the execution 
and delivery of this Agreement.

     2.1  Investment Purpose.  Purchaser is purchasing the Common Shares and 
the Warrants for Purchaser's own account for investment only and not with a 
view toward or in connection with the public sale or distribution thereof. 
Purchaser will not, directly or indirectly, offer, sell, pledge (subject to 
Section 4.11) or otherwise transfer its Common Shares or Warrants or any 
interest therein except pursuant to transactions that are exempt from the 
registration requirements of the Securities Act and/or sales registered under 
the Securities Act. Purchaser understands that Purchaser must bear the 
economic risk of this investment indefinitely, unless the Securities are 
registered pursuant to the Securities Act and any applicable state securities 
laws or an exemption from such registration is available, and that the 
Company has no present intention of registering any such Securities other 
than as contemplated by the Registration Rights Agreement. By making the 
representations in this Section 2.1, Purchaser does not agree to hold the 
Securities for any minimum or other specific term (except as provided in the 
Lock-Up Agreement) and reserves the right to dispose of the Securities at any 
time in accordance with or pursuant to a registration statement or an 
exemption from registration under the Securities Act and any applicable state 
securities laws.

     2.2  Accredited Investor Status.  Purchaser is an "accredited investor" 
as that term is defined in Rule 501(a) of Regulation D.

     2.3  Reliance on Exemptions.  Purchaser understands that the Common 
Shares and Warrants are being offered and sold to Purchaser in reliance upon 
specific exemptions from the registration 


<PAGE>

requirements of United States federal and state securities laws and that the 
Company is relying upon the truth and accuracy of, and Purchaser's compliance 
with, the representations, warranties, agreements, acknowledgments and 
understandings of Purchaser set forth herein in order to determine the 
availability of such exemptions and the eligibility of Purchaser to acquire 
the Common Shares and Warrants.

     2.4  Information.  Purchaser or its counsel have been furnished all 
materials relating to the business, finances and operations of the Company 
and materials relating to the offer and sale of the Securities which have 
been specifically requested by Purchaser, including without limitation the 
Company's Annual Report on Form 10-K for the Year ended December 31, 1996, 
Quarterly Reports on Form 10-Q for the periods ended March 31, 1997 and June 
30, 1997, filed with the Securities and Exchange Commission ("SEC") and Proxy 
Statement dated April 25, 1997 (such documents collectively, the "SEC 
Documents"). Purchaser has been afforded the opportunity to ask questions of 
the Company and has received what Purchaser believes to be complete and 
satisfactory answers to any such inquiries. Neither such inquiries nor any 
other due diligence investigation conducted by Purchaser or any of its 
representations shall modify, amend or affect Purchaser's right to rely on 
the Company's representations and warranties contained in Article III. 
Purchaser understands that Purchaser's investment in the Securities involves 
a high degree of risk, including without limitation the risks and 
uncertainties disclosed in the  SEC Documents. Purchaser acknowledges the 
disclosures presented under the caption "Risk Factors" in the Company's Form 
10-K filed on March 31, 1997, and the incorporation of those  disclosures by 
reference herein.

     2.5  Governmental Review.  Purchaser understands that no United States 
federal or state agency or any other government or governmental agency has 
passed upon or made any recommendation or endorsement of the Securities.

     2.6  Transfer or Resale.  Purchaser understands that (i) except as 
provided in the Registration Rights Agreement, the Securities have not been 
and are not being registered under the Securities Act or any state securities 
laws, and may not be offered, sold, pledged (subject to Section 4.11 of this 
Agreement) or otherwise transferred unless subsequently registered thereunder 
or an exemption from such registration is available (which exemption the 
Company expressly agrees may be established as contemplated in clauses (b) 
and (c) of Section 5.1 hereof); (ii) any sale of such Securities made in 
reliance on Rule 144 under the Securities Act (or a successor rule) ("Rule 
144") may be made only in accordance with the terms of Rule 144 and further, 
if Rule 144 is not applicable, any resale of such Securities without 
registration under the Securities Act under circumstances in which the seller 
may be deemed to be an underwriter (as that term is defined in the Securities 
Act) may require compliance with some other exemption under the Securities 
Act or the rules and regulations of the SEC thereunder in order for such 
resale to be allowed, and (iii) neither the Company nor any other person is 
under any obligation to register such Securities under the Securities Act or 
any state securities laws or to comply with the terms and conditions of any 
exemption thereunder (in each case, other than pursuant to this Agreement or 
the Registration Rights Agreement).

     2.7  Legends.  Purchaser understands that, subject to Article V hereof, 
the certificates for the Warrants and, until such time as the Common Shares 
and Warrant Shares have been registered under the Securities Act as 
contemplated by the Registration Rights Agreement or otherwise may be sold by 
Purchaser pursuant to Rule 144 (subject to and in accordance with the 
procedures specified in Article V hereof), the certificates for the Common 
Shares and Warrant Shares and the Warrants will bear a restrictive legend 
(the "Legend") in the following form:

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER 
THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE 
OF THE UNITED STATES. THE SECURITIES REPRESENTED HEREBY MAY NOT BE OFFERED OR 
SOLD OR OTHERWISE TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION 
STATEMENT FOR THE SECURITIES UNDER APPLICABLE SECURITIES LAWS OR UNLESS 
OFFERED, SOLD OR TRANSFERRED PURSUANT TO AN AVAILABLE EXEMPTION FROM THE 
REGISTRATION REQUIREMENTS OF THOSE LAWS.


<PAGE>

     2.8  Authorization: Enforcement.  This Agreement and the Registration 
Rights Agreement have been duly and validly authorized, executed and 
delivered on behalf of Purchaser and are valid and binding agreements of 
Purchaser enforceable in accordance with its respective terms, except to the 
extent that such validity or enforceability may be subject to or affected by 
any bankruptcy, insolvency, reorganization, moratorium, liquidation or 
similar laws relating to, or affecting generally the enforcement of, 
creditors' rights or remedies of creditors generally, or by other equitable 
principles of general application.

     2.9  Residency.  Purchaser is a resident of the jurisdiction set forth 
under Purchaser's name on the signature page hereto executed by Purchaser.

     2.10 Additional Financing.  Each Purchaser acknowledges that the Company 
expects to close, within 30 days of Closing, the sale of Common Stock and 
warrants in addition to the Common Shares sold hereunder with at a sales 
price of $50.00 per share at the time of such sale of up to $____________ 
(the "Additional Financing") in accordance with the terms attached hereto as 
Schedule 2.10 and otherwise on substantially the same terms and conditions as 
the financing hereunder.  Each Purchaser acknowledges that the Company has 
provided no assurances that the Additional Financing will be completed.

ARTICLE III
REPRESENTATIONS AND WARRANTIES OF THE COMPANY

The Company represents and warrants to each Purchaser as of the date hereof 
and as of the Closing that:

     3.1  Organization and Qualification.  Each of the Company and its 
subsidiaries is a corporation duly organized and existing in good standing 
under the laws of the jurisdiction in which it is incorporated, and has the 
requisite corporate power to own its properties and to carry on its business 
as now being conducted. The Company and each of its subsidiaries is duly 
qualified as a foreign corporation to do business and is in good standing in 
every jurisdiction where the failure so to qualify or be in good standing 
would have a Material Adverse Effect.  "Material Adverse Effect" means any 
effect which, individually or in the aggregate  with all other effects, 
reasonably would be expected to be materially adverse to the business, 
operations, properties, financial condition, operating results or prospects 
of the Company and its subsidiaries, taken as a whole on a consolidated basis 
or on the transactions contemplated hereby.

     3.2  Authorization; Enforcement.  (a) The Company has the requisite 
corporate power and authority to enter into and perform this Agreement, the 
Lock-Up Agreement and the Registration Rights Agreement, and to issue, sell 
and perform its obligations with respect to the Common Shares and Warrants in 
accordance with the terms hereof and thereof and the terms of the Common 
Shares and Warrants, and to issue Warrant Shares in accordance with the terms 
and conditions of the Warrants; (b) the execution, delivery and performance 
of this Agreement, the Lock-Up Agreement and the Registration Rights 
Agreement by the Company and the consummation by it of the transactions 
contemplated hereby and thereby (including, without limitation, the issuance 
of the Common Shares and the Warrants, and the issuance and reservation for 
issuance of the Warrant Shares) have been duly authorized by all necessary 
corporate action and, except as set forth on Schedule 3.2 hereof, no further 
consent or authorization of the Company, its board of directors, or its 
stockholders or any other person, body or agency is required with respect to 
any of the transactions contemplated hereby or thereby (whether under rules 
of the Nasdaq National Market ("Nasdaq"), the National Association of 
Securities Dealers, Inc. or otherwise); (c) this Agreement, the Lock-Up 
Agreement, the Registration Rights Agreement, certificates for the Common 
Shares, and the Warrants have been duly executed and delivered by the 
Company; and (d) this Agreement, the Registration Rights Agreement, the 
Common Shares, and the Warrants constitute legal, valid and binding 
obligations of the Company enforceable against the Company in accordance with 
their respective terms, except (i) to the extent that such validity or 
enforceability may be subject to or affected by any bankruptcy, insolvency, 
reorganization, moratorium, liquidation or similar laws relating to, or 
affecting


<PAGE>

generally the enforcement of, creditors' rights or remedies of creditors 
generally, or by other equitable principles of general application, and (ii) 
as rights to indemnity and contribution under the Registration Rights 
Agreement may be limited by Federal or state securities laws.

     3.3  Capitalization.  The capitalization of the Company as of the date 
hereof, including the authorized capital stock, the number of shares issued 
and outstanding, the number of shares reserved for issuance pursuant to the 
Company's stock option plans, the number of shares reserved for issuance 
pursuant to securities (other than the Warrants) exercisable for, or 
convertible into or exchangeable for, any shares of Common Stock and the 
number of shares to be reserved for issuance upon exercise of the Warrants is 
set forth on Schedule 3.3. All of such outstanding shares of capital stock 
have been, or upon issuance will be, validly issued, fully paid and 
nonassessable. No shares of capital stock of the Company (including the 
Common Shares and the Warrant Shares) are subject to preemptive rights or any 
other similar rights of the stockholders of the Company or any liens or 
encumbrances. Except as disclosed in Schedule 3.3, as of the date of this 
Agreement, (i) there are no outstanding options, warrants, scrip, rights to 
subscribe for, calls or commitments of any character whatsoever relating to, 
or securities or rights convertible into or exercisable or exchangeable for, 
any shares of capital stock of the Company or any of its subsidiaries, or 
contracts, commitments, understandings or arrangements by which the Company 
or any of its subsidiaries is or may become bound to issue additional shares 
of capital stock of the Company or any of its subsidiaries, (ii) issuance of 
the Securities will not trigger antidilution rights for any other outstanding 
or authorized securities of the Company, and (iii) there are no agreements or 
arrangements under which the Company or any of its subsidiaries is obligated 
to register the sale of any of its or their securities under the Securities 
Act (except the Registration Rights Agreement). The Company has furnished to 
Purchaser true and correct copies of the Company's Certificate of 
Incorporation as in effect on the date hereof ("Certificate of 
Incorporation"), and the Company's By-laws as in effect on the date hereof 
(the "By-laws"). The Company has set forth on Schedule 3.3 all instruments 
and agreements (other than the Certificate of Incorporation and By-laws) 
governing securities convertible into or exercisable or exchangeable for 
Common Stock of the Company (and the Company shall provide to Purchaser 
copies thereof upon the request of Purchaser). The Company shall provide 
Purchaser with a written update of this representation signed by the 
Company's Chief Executive Officer or Chief Financial Officer on behalf of the 
Company as of the date of the Closing.

     3.4  Issuance of Shares.  The Common Shares and Warrant Shares are duly 
authorized and reserved for issuance, and, in the case of the Warrants, upon 
the exercise of the Warrants in accordance with the terms thereof, as 
applicable, will be validly issued, fully paid and non-assessable, and free 
from all taxes, liens, claims and encumbrances imposed or suffered by the 
Company and will not be subject to preemptive rights or other similar rights 
of stockholders of the Company. The Common Shares and Warrants are duly 
authorized and validly issued, fully paid and nonassessable, and free from 
all liens, claims and encumbrances imposed or suffered by the Company and are 
not and will not be subject to preemptive rights or other similar rights of 
stockholders of the Company.

     3.5  No Conflicts.  The execution, delivery and performance of this 
Agreement and the Registration Rights Agreement by the Company, and the 
consummation by the Company of transactions contemplated hereby and thereby 
(including, without limitation, the issuance and reservation for issuance, as 
applicable, of the Common Shares, Warrants, and Warrant Shares) do not and 
will not (a) result in a violation of the Certificate of Incorporation or 
By-laws or (b) conflict with, or constitute a default (or an event which, 
with notice or lapse of time or both, would become a default) under, or give 
to others any rights of termination, amendment, acceleration or cancellation 
of, any agreement, indenture or instrument to which the Company or any of its 
subsidiaries is a party, or result in a violation of any law, rule, 
regulation, order, judgment or decree (including U.S. federal and state 
securities laws and regulations and the rules and regulations of NASDAQ) 
applicable to the Company or any of its subsidiaries, or by which any 
property or asset of the Company or any of its subsidiaries, is bound or 
affected (except for such possible conflicts, defaults, terminations, 
amendments, accelerations, cancellations and violations as would not, 
individually or in the aggregate, have a Material Adverse Effect). Neither 
the Company nor any of its subsidiaries is in violation of its Certificate of 
Incorporation or other organizational documents, and neither the Company nor 
any of its subsidiaries, is in default (and no event has occurred which has 
not been

<PAGE>

waived which, with notice or lapse of time or both, would put the Company or 
any of its subsidiaries in default) under, nor has there occurred any event 
giving others (with notice or lapse of time or both) any rights of 
termination, amendment, acceleration or cancellation of, any agreement, 
indenture or instrument to which the Company or any of its subsidiaries is a 
party, except for possible violations, defaults or rights as would not, 
individually or in the aggregate, have a Material Adverse Effect. The 
businesses of the Company and its subsidiaries are not being conducted, and 
shall not be conducted so long as a Purchaser owns any of the Securities, in 
violation of any law, ordinance or regulation of any governmental entity, 
except for possible violations the sanctions for which either individually or 
in the aggregate would not have a Material Adverse Effect. Except as set 
forth on Schedule 3.5, or except (A) such as may be required under the 
Securities Act in connection with the performance of the Company's 
obligations under the Registration Rights Agreement, (B) filing of a Form D 
with the SEC, and (C) compliance with the state securities or Blue Sky laws 
of applicable jurisdictions, the Company is not required to obtain any 
consent, authorization or order of, or make any filing or registration with, 
any court or governmental agency or any regulatory or self-regulatory agency 
in order for it to execute, deliver or perform any of its obligations under 
this Agreement, the Lock-Up Agreement or the Registration Rights Agreement or 
to perform its obligations in accordance with the terms hereof or thereof. 
The Company is not in violation of the listing requirements of Nasdaq and 
does not reasonably anticipate that the Common Stock will be delisted by 
Nasdaq for the foreseeable future.

     3.6  SEC Documents.  Except as disclosed in Schedule 3.6, since December 
31, 1995, the Company has timely filed all reports, schedules, forms, 
statements and other documents required to be filed by it with the SEC 
pursuant to the reporting requirements of the Securities Exchange Act of 
1934, as amended (the "Exchange Act") (all of the foregoing filed after 
December 31, 1995 and all exhibits included therein and financial statements 
and schedules thereto and documents incorporated by reference therein, being 
referred to herein as the "SEC Documents"). The Company has delivered to each 
Purchaser true and complete copies of the SEC Documents, except for exhibits, 
schedules and incorporated documents. As of their respective dates, the SEC 
Documents complied in all material respects with the requirements of the 
Exchange Act and the rules and regulations of the SEC promulgated thereunder 
applicable to the SEC Documents, and none of the SEC Documents, at the time 
they were filed with the SEC, contained any untrue statement of a material 
fact or omitted to state a material fact required to be stated therein or 
necessary in order to make the statements therein, in light of the 
circumstances under which they were made, not misleading. None of the 
statements made in any such SEC Documents which is required to be updated or 
amended under applicable law has not been so updated or amended. The 
financial statements of the Company included in the SEC Documents have been 
prepared in accordance with U.S. generally accepted accounting principles, 
consistently applied, and the rules and regulations of the SEC during the 
periods involved (except (i) as may be otherwise indicated in such financial 
statements or the notes thereto, or (ii) in the case of unaudited interim 
statements, to the extent they do not include footnotes or are condensed or 
summary statements) and present accurately and completely the consolidated 
financial position of the Company and its consolidated subsidiaries as of the 
dates thereof and the consolidated results of their operations and cash flows 
for the periods then ended (subject, in the case of unaudited statements, to 
normal year-end audit adjustments). Except as set forth in a manner clearly 
evident to a sophisticated institutional investor in the financial statements 
or the notes thereto of the Company included in the SEC Documents, the 
Company has no liabilities, contingent or otherwise, other than (i) 
liabilities incurred in the ordinary course of business consistent with past 
practice subsequent to the date of such financial statements and (ii) 
obligations under contracts and commitments incurred in the ordinary course 
of business consistent with past practice and not required under generally 
accepted accounting principles to be reflected in such financial statements, 
in each case of clause (i) and (ii) next above which, individually or in the 
aggregate, are not material to the financial condition, business, operations, 
properties, operating results or prospects of the Company and its 
subsidiaries. To the extent required by the rules of the SEC applicable 
thereto, the SEC Documents contain a complete and accurate list of all 
material undischarged written or oral contracts, agreements, leases or other 
instruments to which the Company or any subsidiary is a party or by which the 
Company or any subsidiary is bound or to which any of the properties or 
assets of the Company or any subsidiary is subject (each a "Contract"). 
Except as set forth in Schedule 3.6, none of the Company, its subsidiaries 
or, to the best knowledge of the Company, 


<PAGE>

any of the other parties thereto, is in breach or violation of any Contract, 
which breach or violation would have a Material Adverse Effect. No event, 
occurrence or condition exists which, with the lapse of time, the giving of 
notice, or both, would become a default by the Company or its subsidiaries 
thereunder which would have a Material Adverse Effect.  The Company has not 
provided to any Purchaser any material non-public information or any other 
information which, according to applicable law, rule or regulation, should 
have been disclosed publicly by the Company but which has not been so 
disclosed.

     3.7  Absence of Certain Changes.  Since December 31, 1996, there has 
been no material adverse change and no material adverse development in the 
business, properties, operations, financial condition, results of operations 
or prospects of the Company, except as disclosed in Schedule 3.7 or clearly 
evident to a sophisticated institutional investor from the  SEC Documents.

     3.8  Absence of Litigation.  Except as disclosed in Schedule 3.8 or as 
clearly evident to a sophisticated institutional investor from the  SEC 
Documents, there is no action, suit, proceeding, inquiry or investigation 
before or by any court, public board, government agency, or self-regulatory 
organization or body pending or, to the knowledge of the Company or any of 
its subsidiaries, threatened against or affecting the Company, any of its 
subsidiaries, or any of their respective directors or officers in their 
capacities as such, which could reasonably be expected to result in an 
unfavorable decision, ruling or finding which would have a Material Adverse 
Effect or would adversely affect the transactions contemplated by this 
Agreement or any of the documents contemplated hereby or which would 
adversely affect the validity or enforceability of, or the authority or 
ability of the Company to perform its obligations under, this Agreement or 
any of such other documents. There are no facts known to the Company which, 
if known by a potential claimant or governmental authority, could reasonably 
be expected to give rise to a claim or proceeding which, if asserted or 
conducted with results unfavorable to the Company or any of its subsidiaries, 
could reasonably be expected to have a Material Adverse Effect.

     3.9  Disclosure.  No information relating to or concerning the Company 
set forth in this Agreement contains an untrue statement of a material fact. 
No information relating to or concerning the Company set forth in any of the  
SEC Documents contains a statement of material fact that was untrue as of the 
date such SEC Document was filed with the SEC. The Company has not omitted to 
state a material fact necessary in order to make the statements made herein 
or therein, in light of the circumstances under which they were made, not 
misleading. Except for the execution and performance of this Agreement, no 
material fact (within the meaning of the federal securities laws of the 
United States and of applicable state securities laws) exists with respect to 
the Company which has not been publicly disclosed.

     3.10      Acknowledgment Regarding Purchaser's Purchase of the 
Securities. The Company acknowledges and agrees that Purchaser is not acting 
as a financial advisor or fiduciary of the Company (or in any similar 
capacity) with respect to this Agreement or the transactions contemplated 
hereby, that this Agreement and the transaction contemplated hereby, and the 
relationship between each Purchaser and the Company, are "arms-length", and 
that any statement made by Purchaser (except as set forth in Article II), or 
any of its representatives or agents, in connection with this Agreement and 
the transactions contemplated hereby is not advice or a recommendation, is 
merely incidental to Purchaser's purchase of the Securities and has not been 
relied upon as such in any way by the Company, its officers or directors. The 
Company further represents to Purchaser that the Company's decision to enter 
into this Agreement and the transactions contemplated hereby have been based 
solely on an independent evaluation by the Company and its representatives.

     3.11      S-3 Registration.  The Company is currently eligible to 
register the resale by Purchaser of the Warrant Shares and to register the 
Common Shares on a registration statement on Form S-3 under the Securities 
Act.

     3.12 No General Solicitation.  Neither the Company nor any distributor
participating on the Company's behalf in the transactions contemplated hereby
(if any) nor any person acting for the Company, 


<PAGE>

or any such distributor, has conducted any "general solicitation," as 
described in Rule 502(c) under Regulation D, with respect to any of the 
Securities being offered hereby.

     3.13      No Integrated Offering.  Neither the Company, nor any of its 
affiliates, nor any person acting on its or their behalf, has directly or 
indirectly made any offers or sales of any security or solicited any offers 
to buy any security under circumstances that would prevent the parties hereto 
from consummating the transactions contemplated hereby pursuant to an 
exemption from the registration under the Securities Act pursuant to the 
provisions of Regulation D.  The transactions contemplated hereby are exempt 
from the registration requirements of the Securities Act, assuming the 
accuracy of the representations and warranties herein contained of each 
Purchaser.

     3.14      No Brokers.  The Company has taken no action which would give 
rise to any claim by any person for brokerage commissions, finder's fees or 
similar payments by Purchaser relating to this Agreement or the transactions 
contemplated hereby.

     3.15      Intellectual Property.  Each of the Company and its 
subsidiaries owns or possesses adequate and enforceable rights to use all 
material patents, patent applications, trademarks, trademark applications, 
trade names, service marks, copyrights, copyright applications, licenses, 
know-how (including trade secrets and other unpatented and/or unpatentable 
proprietary or confidential information, systems or procedures) and other 
similar rights and proprietary knowledge (collectively, "Intangibles") used 
or necessary for the conduct of its business as now being conducted and as 
described in the Company's Annual Report on Form 10-K for its most recently 
ended fiscal year. Neither the Company nor any subsidiary of the Company 
infringes on or is in conflict with any right of any other person with 
respect to any Intangibles nor is there any claim of infringement made by a 
third party against or involving the Company or any of its subsidiaries, 
which infringement, conflict or claim, individually or in the aggregate, 
could reasonably be expected to result in an unfavorable decision, ruling or 
finding which would have a Material Adverse Effect.

     3.16      Key Employees.  Each Key Employee (as defined below) is 
currently serving the Company in the capacity disclosed in Schedule 3.16. No 
Key Employee, to the best of the knowledge of the Company and its 
subsidiaries, is, or is now expected to be, in violation of any material term 
of any employment contract, confidentiality, disclosure or proprietary 
information agreement, non-competition agreement, or any other contract or 
agreement or any restrictive covenant, and the continued employment of each 
Key Employee does not subject the Company or any of its subsidiaries to any 
liability with respect to any of the foregoing matters. No Key Employee has, 
to the best of the knowledge of the Company and its subsidiaries, any 
intention to terminate his employment with, or services to, the Company or 
any of its subsidiaries. "Key Employee" means each of Gary S. Kledzik and 
David E. Mai.

     3.17 Rights Plan.  The Company does not have in effect a shareholders 
rights plan or similar plan in the nature of a "poison pill."  If the Company 
adopts such a plan, the Purchaser's Common Shares, Warrant Shares and Shares 
receivable pursuant to Section 5.3 will not be deemed to trigger such plan.

ARTICLE IV
COVENANTS

     4.1  Best Efforts.  The parties shall use their best efforts to timely 
satisfy each of the conditions described in Articles VI and VII of this 
Agreement.

     4.2  Securities Laws.  The Company agrees to file a Form D with respect 
to the Securities with the SEC as required under Regulation D and to provide 
a copy thereof to each Purchaser within fifteen (15) days after the date of 
Closing. The Company agrees to file a Form 8-K disclosing this Agreement and 
the transactions contemplated hereby with the SEC within ten (10) business 
days following the date of Closing. The Company shall, on or prior to the 
date of Closing, take such action as is necessary to sell the Securities to 
each Purchaser under applicable securities laws of the states of the United 
States, 


<PAGE>

and shall provide evidence of any such action so taken to each Purchaser on 
or prior to the date of the Closing.

     4.3  Reporting Status.  So long as any Purchaser beneficially owns any 
of the Securities, (a) the Company shall timely file all reports required to 
be filed with the SEC pursuant to the Exchange Act, and the Company shall not 
terminate its status as an issuer required to file reports under the Exchange 
Act even if the Exchange Act or the rules and regulations thereunder would 
permit such termination, and (b) the Company will maintain its ability to 
register its Common Stock on Form S-3.

     4.4  Restriction on Certain Issuances of Securities.  (a) For a period 
of one year following the date of Closing, the Company shall not issue or 
agree to issue, (except (i) to Purchaser pursuant to this Agreement, (ii) 
pursuant to any employee stock option, stock purchase or restricted stock 
plan of the Company in effect on the date hereof up to the aggregate amounts 
set forth on Schedule 4.5 hereto, (iii) pursuant to any existing security, 
option, warrant, scrip, call or commitment or right in each case or disclosed 
on Schedule 3.3 hereof, (iv) pursuant to any grant or exercise of any 
consultant warrants or options granted or awarded in the reasonable 
discretion of the Board of Directors, (v) beginning ninety (90) days 
following the date of the Closing, pursuant to a strategic joint venture or 
partnership entered into by the Company, undertaken at the reasonable 
discretion of the Board of Directors of the Company, the primary purpose of 
which is not to raise equity capital or (vi) the Additional Financing 
reflected in Section 2.10), any equity securities of the Company (or any 
security convertible into or exercisable or exchangeable, directly or 
indirectly, for equity securities of the Company) if such securities are 
issued at a price (or in the case of securities convertible into or 
exercisable or exchangeable, directly or indirectly, for Common Stock such 
securities provide for a conversion, exercise or exchange price) which may be 
less than the current market price for Common Stock on the date of issuance 
(in the case of Common Stock) or the date of conversion, exercise or exchange 
(in the case of securities convertible into or exercisable or exchangeable, 
directly or indirectly, for Common Stock).

     4.5  Right of First Offer.  From the date hereof until the day following 
the six-month anniversary of the date of the Closing, the Company shall not 
issue or sell, or agree to issue or sell any equity securities of the Company 
or any of its subsidiaries (or any security convertible into or exercisable 
or exchangeable, directly or indirectly, for equity securities of the Company 
or any of its subsidiaries) ("Future Offerings") unless the Company shall 
have first delivered to each Purchaser at least ten (10) business days prior 
to the closing of such Future Offering, written notice describing the 
proposed Future Offering, including the terms and conditions thereof, and 
providing each Purchaser and its affiliates an option during the ten (10) 
business day period following delivery of such notice to purchase up to the 
full amount of the securities being offered in the Future Offering on the 
same terms as contemplated by such Future Offering [on a pro-rata basis to 
all other purchasers of the Company's Common Stock pursuant to the Agreement 
between the Company and certain investors for $__________ and the Additional 
Financing] (the limitations referred to in this sentence are collectively 
referred to as the "Capital Raising Limitations"); provided that if 
oversubscribed, the Future Offering will be allocated to the Purchaser pro 
rata in proportion to the amount of its initial purchase of Securities 
hereunder. The Capital Raising Limitations shall not apply to the Additional 
Financing referred to in Section 2.10 or any transaction involving issuances 
of securities in connection with a merger, consolidation, joint venture, 
asset acquisition, license agreement, strategic alliance, grant or exercise 
of options to or by employees, consultants or directors. In addition, the 
Capital Raising Limitations also shall not apply to the issuance of 
securities upon exercise or conversion of the Company's options, warrants or 
other convertible securities outstanding as of the date hereof, the grant of 
additional options or warrants, or the issuance of additional securities, 
under any employee, director or consulting stock option, stock purchase or 
restricted stock plan of the Company or any firm commitment underwritten 
public offering. This Section 4.5 shall not limit the Company's obligations 
under Section 4.4 above. The Company shall prohibit any Common Stock or other 
security issued by the Company subject to the Capital Raising Limitations but 
not purchased by any Purchaser from being converted, exercised or resold 
until the day following the six-month anniversary of the date of the Closing 
and shall take all actions necessary (including, without limitation, the 
issuance of a stop transfer order) to effect such prohibition.


<PAGE>

     4.6  Information.  The Company agrees to send the following reports to 
each Purchaser until such Purchaser transfers, assigns or sells all of its 
Securities in transactions in which the transferee is (unless such transferee 
is an affiliate of the Company) not subject to securities law resale 
restrictions: (a) within three (3) business days after the filing with the 
SEC, a copy of its Annual Report on Form 10-K, its Quarterly Reports on Form 
10-Q, any proxy statements and any Current Reports on Form 8-K; and (b) 
within one (1) business day after release, copies of all press releases 
issued by the Company or any of its subsidiaries. The Company further agrees 
to promptly provide to any Purchaser any information with respect to the 
Company, its properties, or its business or Purchaser's investment as such 
Purchaser may reasonably request; provided, however, that the Company shall 
not be required to give any Purchaser any material nonpublic information. If 
any information requested by a Purchaser from the Company contains material 
nonpublic information, the Company shall inform the Purchaser in writing that 
the information requested contains material nonpublic information and shall 
in no event provide such information to Purchaser without the express written 
consent of such Purchaser after being so informed.

     4.7  Listing.  The Company shall continue the uninterrupted listing and 
trading of its Common Stock on the Nasdaq or the New York Stock Exchange or 
the American Stock Exchange; and comply in all respects with the Company's 
reporting, filing and other obligations under the By-laws or rules of the 
Nasdaq or such Exchange, as applicable.

     4.8  Prospectus Delivery Requirement.  Each Purchaser understands that 
the Securities Act may require delivery of a prospectus relating to the 
Common Stock in connection with any sale thereof pursuant to a registration 
statement under the Securities Act covering the resale by such Purchaser of 
the Common Stock being sold, and each Purchaser shall comply with the 
applicable prospectus delivery requirements of the Securities Act in 
connection with any such sale.

     4.9  Corporate Existence.  So long as any Purchaser beneficially owns 
any Warrants or Common Stock, the Company shall maintain its corporate 
existence, except in the event of a merger, consolidation or sale of all or 
substantially all of the Company's assets, as long as the surviving or 
successor entity in such transaction (i) assumes the Company's obligations 
hereunder and under the agreements and instruments entered into in connection 
herewith and (ii) is a publicly traded corporation whose common stock is 
listed for trading on the NASDAQ, the New York Stock Exchange or the American 
Stock Exchange.

     4. 10     Hedging Transactions. No Purchaser has an existing short 
position with respect to the Common Shares.  Each Purchaser agrees not to, 
directly or indirectly, enter into any short sales with respect to the Common 
Shares prior to the date on which such Purchaser is entitled to sell, 
transfer or dispose pursuant to the Lock-Up Agreement the number of shares of 
Common Stock as to which such Purchaser proposes to establish a short 
position.   This Section 4.10 shall not prohibit Purchaser from at any time 
entering into options contracts with respect to the Common Shares, including 
puts and calls including delivering Common Stock in satisfaction of any 
exercised options. Purchaser shall not, however, be permitted to deliver 
Common Shares in satisfaction of any exercised options (unless, at the time 
of such delivery, Disposition (as defined in the Lock-Up Agreement) of such 
Common Shares is permitted under the Lock-Up Agreement).

     4.11 Pledging and Margining.  Notwithstanding anything in this Agreement 
to the Contrary, Purchaser may pledge, margin or otherwise encumber the 
Common Shares unless the result of any such activity would be that such 
Common Shares would be available for lending and/or borrowing in connection 
with short sales of the Common Stock by any third party.

     4.12 Cash Maintenance Requirement.  From the date of the Closing through 
the first anniversary of the date of the Closing, the Company shall maintain, 
as of the end of each fiscal quarter of the Company, cash or cash equivalents 
(as reflected in the Company's quarterly financial statements) equal to at 
least Twenty Million Dollars ($20,000,000).


<PAGE>

     4.13 Use of Proceeds.  The Company will use the proceeds of the sale of 
the Securities for working capital or such other purposes as management or 
the Company's Board of Directors shall determine.

     4.14 Management Lock-Up.  The Company will extend its current agreements 
so that no person identified on Schedule 4.14 will be permitted to sell 
shares of Common Stock prior to the Anniversary Date.

ARTICLE V
LEGEND REMOVAL, TRANSFER, CERTAIN SALES, ADDITIONAL SHARES

     5.1  Removal of Legend.  The Legend shall be removed and the Company 
shall issue a certificate without such Legend to the holder of any Security 
upon which it is stamped, and a certificate for a security shall be 
originally issued without the Legend, if, (a) the sale of such Security is 
registered under the Securities Act, (b) such holder provides the Company 
with an opinion of counsel, in form, substance and scope customary for 
opinions of counsel in comparable transactions and reasonably satisfactory to 
the Company and its counsel (the reasonable cost of which shall be borne by 
the Company if neither an effective registration statement under the 
Securities Act or Rule 144 is available in connection with such sale) to the 
effect that a public sale or transfer of such Security may be made without 
registration under the Securities Act pursuant to an exemption from such 
registration requirements or (c) such Security can be sold pursuant to Rule 
144 and the holder provides the Company with reasonable assurances that the 
Security can be so sold without restriction or (d) such Security can be sold 
pursuant to Rule 144(k). Each Purchaser agrees to sell all Securities, 
including those represented by a certificate(s) from which the Legend has 
been removed, or which were originally issued without the Legend, pursuant to 
an effective registration statement, in accordance with the manner of 
distribution described in such registration statement and to deliver a 
prospectus in connection with such sale, or in compliance with an exemption 
from the registration requirements of the Securities Act. In the event the 
Legend is removed from any Security or any Security is issued without the 
Legend and the Security is to be disposed of other than pursuant to the 
registration statement or pursuant to Rule 144, then prior to, and as a 
condition to, such disposition such Security shall be relegended as provided 
herein in connection with any disposition if the subsequent transfer thereof 
would be restricted under the Securities Act. Also, in the event the Legend 
is removed from any Security or any Security is issued without the Legend and 
thereafter the effectiveness of a registration statement covering the resale 
of such Security is suspended or the Company determines that a supplement or 
amendment thereto is required by applicable securities laws, then upon 
reasonable advance notice to Purchaser holding such Security, the Company may 
require that the Legend be placed on any such Security that cannot then be 
sold pursuant to an effective registration statement or Rule 144 or with 
respect to which the opinion referred to in clause (b) next above has not 
been rendered, which Legend shall be removed when such Security may be sold 
pursuant to an effective registration statement or Rule 144 or such holder 
provides the opinion with respect thereto described in clause (b) next above.

5.2   Transfer Agent Instructions.  The Company shall instruct its transfer 
agent to issue certificates, registered in the name of each Purchaser or its 
nominee, for the Common Shares and for the Warrant Shares in such amounts 
determined in accordance with the terms of the Warrants. Such certificates 
shall bear the Legend only to the extent provided by Section 5.1 above and 
the Lock-Up Agreement. The Company covenants that no instruction other than 
such instructions referred to in this Article V, and stop transfer 
instructions to give effect to Section 2.6 hereof in the case of the Common 
Shares and Warrant Shares prior to registration of the Common Shares and 
Warrant Shares under the Securities Act, will be given by the Company to its 
transfer agent and that the Securities shall otherwise be freely transferable 
on the books and records of the Company. Nothing in this Section shall affect 
in any way each Purchaser's obligations and agreement set forth in Section 
5.1 hereof to resell the Securities pursuant to an effective registration 
statement and to deliver a prospectus in connection with such sale or in 
compliance with an exemption from the registration requirements of applicable 
securities laws. If (a) a Purchaser provides the Company with an opinion of 
counsel, which opinion of counsel shall be in form, substance and scope 

<PAGE>

customary for opinions of counsel in comparable transactions and reasonably 
satisfactory to the Company and its counsel (the reasonable cost of which 
shall be borne by the Company if neither an effective registration statement 
under the Securities Act or Rule 144 is available in connection with such 
sale), to the effect that the Securities to be sold or transferred may be 
sold or transferred pursuant to an exemption from registration or (b) a 
Purchaser transfers Securities to an affiliate which is an accredited 
investor (within the meaning of Regulation D under the Securities Act) and 
which delivers to the Company in written form the same representations, 
warranties and covenants made by Purchaser hereunder or pursuant to Rule 144, 
the Company shall permit the transfer, and, in the case of the Common Shares 
and Warrant Shares, promptly instruct its transfer agent to issue one or more 
certificates in such name and in such denomination as specified by such 
Purchaser. The Company acknowledges that a breach by it of its obligations 
hereunder will cause irreparable harm to a Purchaser by vitiating the intent 
and purpose of the transaction contemplated hereby. Accordingly, the Company 
acknowledges that the remedy at law for a breach of its obligations under 
this Article V will be inadequate and agrees, in the event of a breach or 
threatened breach by the Company of the provisions of this Article V, that a 
Purchaser shall be entitled, in addition to all other available remedies, to 
an injunction restraining any breach and requiring immediate issuance and 
transfer, without the necessity of showing economic loss and without any bond 
or other security being required.

5.3  Additional Shares or Cash Payment.  If on the first anniversary of the 
date of the Closing (the "Anniversary Date") the 30 day average closing bid 
price of the Common Stock (as  reported by Bloomberg L.P.) for the period 
ending on the trading day prior to the Anniversary Date (the "Anniversary 
Price") is less than $50.00 (the "Closing Price"), then the Company shall, 
at the Company's sole option, either:
   
     (a)    Pay to each Purchaser, within 10 days of the Anniversary Date, in 
cash, an amount determined in accordance with the following formula: 

     P = (C - A)*S

     where:

     P = the aggregate payment to be made to such Purchaser, expressed in 
     dollars;

     C = the Closing Price;

     A = the Anniversary Price; and

     S = the aggregate number of the Common Shares purchased by the Purchaser 
     and not sold or assigned (other than to an affiliate of the Purchaser) 
     in accordance with Section 1.2 of the Lock-Up Agreement during the 
     period from the date of the Closing through the Anniversary Date; or
    
   
    (b)  Issue, within 10 days of the Anniversary Date, to each Purchaser a 
number of additional shares of Common Stock equal to the product of (i) the 
dollar amount calculated pursuant to Section 5.3(a) with respect to such 
Purchaser divided by (ii) the Anniversary Price.
    
The foregoing P, C, A and S shall be equitably adjusted to reflect the effect 
of any stock dividends, stock splits, reverse stock splits, discounted equity 
offerings or actions similar to any of the foregoing.

If the Company intends to satisfy its obligations under this Section 5.3 
through the issuance of  additional Common Stock pursuant to Section 5.3(b), 
the following conditions shall apply:  (u) the issuance of Common Stock will 
only be permitted to the extent that such issuance will not result in any 
Purchaser, or any group which such entity will be deemed under the Securities 
Act to be a part of, solely as a result of the issuance of such additional 
shares, the Common Shares and the Warrant Shares, having beneficial 

<PAGE>

ownership (as defined in Section 13(d) of the Securities Act) of more than 
9.9% of the Common Stock; (w) Common Stock shall be listed on NASDAQ, NYSE or 
AMEX; (x) the Company shall issue only freely tradable, registered and 
unlegended Common Stock; (y) the Company must provide each Purchaser on or 
before the Anniversary Date of its election to so issue Common Stock; and (z) 
the Company must satisfy its obligations under Section 5.3 through the 
issuance of Common Stock to each of the Purchaser who continues to hold 
Common Shares.  Notwithstanding anything in this Section 5.3 to the contrary, 
no holder of any shares of Common Stock other than the initial Purchaser 
signatory hereto and any permitted assignee who receives restricted 
securities pursuant to Section 8.7 shall be entitled to payments or 
additional shares of Common Stock from the Company pursuant to this Section 
5.3.  The Company will have no obligations under this Section 5.3 with 
respect to the Warrants or the Warrant Shares.

ARTICLE VI
CONDITIONS TO THE COMPANY'S OBLIGATION TO SELL

6.1  Conditions to the Company's Obligation to Sell.  The obligation of the 
Company hereunder to issue and sell the Common Shares and Warrants to a 
Purchaser at the Closing is subject to the satisfaction, as of the date of 
the Closing and with respect to such Purchaser, of each of the following 
conditions thereto, provided that these conditions are for the Company's sole 
benefit and may be waived by the Company at any time in its sole discretion:

(i)       Such Purchaser shall have executed and delivered the signature page 
to this Agreement, the Registration Rights Agreement and the Lock-Up 
Agreement.

(ii)      Such Purchaser shall have wired to the account designated by the 
Company.

(iii)     The representations and warranties of such Purchaser shall be true
and correct in all material respects as of the date when made and as of the
Closing as though made at that time (except for representations and warranties
that speak as of a specific date), and such Purchaser shall have performed,
satisfied and complied in all material respects with the covenants, agreements
and conditions required by this Agreement to be performed, satisfied or
complied with by the applicable Purchaser at or prior to the Closing.

(iv)      No statute, rule, regulation, executive order, decree, ruling or 
injunction shall have been enacted, entered, promulgated or endorsed by any 
court or governmental authority of competent jurisdiction or any 
self-regulatory organization having authority over the matters contemplated 
hereby which restricts or prohibits the consummation of any of the 
transactions contemplated by this Agreement.

ARTICLE VII
CONDITIONS TO EACH PURCHASER'S OBLIGATION TO PURCHASE

7.1      The obligation of each Purchaser hereunder to purchase the Common 
Shares and Warrants to be purchased by it on the date of the Closing is 
subject to the satisfaction of each of the following conditions, provided 
that these conditions are for each Purchaser's sole benefit and may be waived 
by such Purchaser at any time in such Purchaser's sole discretion:

(i)       The Company shall have executed and delivered the signature page to 
this Agreement, the Registration Rights Agreement and the Lock-Up Agreement.

(ii)      The Company shall have delivered to the Purchaser's counsel duly 
issued certificates for the Common Shares being so purchased by Purchaser and 
Warrants being issued to such Purchaser at the Closing.

(iii)     The Common Stock shall be listed on the Nasdaq and trading in the 
Common Stock shall not have been suspended by the Nasdaq or the SEC or other 
regulatory authority.


<PAGE>

(iv)      The representations and warranties of the Company shall be true and 
correct in all material respects as of the date when made and as of the 
Closing as though made at that time and the Company shall have performed, 
satisfied and complied in all material respects with the covenants, 
agreements and conditions required by this Agreement to be performed, 
satisfied or complied with by the Company at or prior to the Closing. 
Purchaser shall have received a certificate, executed by the Chief Executive 
Officer or Chief Financial Officer of the Company, dated as of the Closing to 
the foregoing effect.

(v)       No statute, rule, regulation, executive order, decree, ruling or 
injunction shall have been enacted, entered, promulgated or endorsed by any 
court or governmental authority of competent jurisdiction or any 
self-regulatory organization having authority over the matters contemplated 
hereby which prohibits the consummation of any of the transactions 
contemplated by this Agreement.

(vi)      Purchaser shall have received the officer's certificate described 
in Section 3.3, dated as of the Closing.

(vii)     Purchaser shall have received opinions of Nida & Maloney, a 
Professional Corporation, counsel to the Company, dated as of the Closing, in 
the form attached hereto as Exhibit D.

ARTICLE VIII
GOVERNING LAW; MISCELLANEOUS

8.1  Governing Law: Jurisdiction.  This Agreement shall be governed by and 
construed in accordance with the Delaware General Corporation Law (in respect 
of matters of corporation law) and the laws of the State of California (in 
respect of all other matters) applicable to contracts made and to be 
performed in the State of California. The parties hereto irrevocably consent 
to the jurisdiction of the United States federal courts and state courts 
located in the County of New Castle in the State of Delaware in any suit or 
proceeding based on or arising under this Agreement or the transactions 
contemplated hereby and irrevocably agree that all claims in respect of such 
suit or proceeding may be determined in such courts. The Company and each 
Purchaser irrevocably waives the defense of an inconvenient forum to the 
maintenance of such suit or proceeding in such forum. The Company and each 
Purchaser further agrees that service of process upon the Company or such 
Purchaser, as applicable, mailed by the first class mail in accordance with 
Section 8.6 shall be deemed in every respect effective service of process 
upon the Company or such Purchaser in any suit or proceeding arising 
hereunder. Nothing herein shall affect Purchaser's right to serve process in 
any other manner permitted by law. The parties hereto agree that a final 
non-appealable judgment in any such suit or proceeding shall be conclusive 
and may be enforced in other jurisdictions by suit on such judgment or in any 
other lawful manner.  The parties hereto irrevocably waive any right to a 
trial by jury under applicable law.

8.2  Counterparts.  This Agreement may be executed in two or more 
counterparts, including, without limitation, by facsimile transmission, all 
of which counterparts shall be considered one and the same agreement and 
shall become effective when counterparts have been signed by each party and 
delivered to the other party. In the event any signature page is delivered by 
facsimile transmission, the party using such means of delivery shall cause 
additional original executed signature pages to be delivered to the other 
parties as soon as practicable thereafter.

8.3  Headings.  The headings of this Agreement are for convenience of reference
and shall not form part of, or affect the interpretation of, this Agreement.

8.4  Severability.  If any provision of this Agreement shall be invalid or 
unenforceable in any jurisdiction, such invalidity or unenforceability shall 
not affect the validity or enforceability of the remainder of this Agreement 
or the validity or enforceability of this Agreement in any other jurisdiction.


<PAGE>

8.5  Entire Agreement: Amendments.  This Agreement and the instruments 
referenced herein contain the entire understanding of the parties with 
respect to the maters covered herein and therein and, except as specifically 
set forth herein or therein, neither the Company nor any Purchaser makes any 
representation, warranty, covenant or undertaking with respect to such 
matters. No provision of this Agreement may be waived other than by an 
instrument in writing signed by the party to be charged with enforcement and 
no provision of this Agreement may be amended other than by an instrument in 
writing signed by the Company and each Purchaser.

     8.6  Notice.   Any notice herein required or permitted to be given shall 
be in writing and may be personally served or delivered by 
nationally-recognized overnight courier or by facsimile machine confirmed 
telecopy, and shall be deemed delivered at the time and date of receipt 
(which shall include telephone line facsimile transmission). The addresses 
for such communications shall be:

          if to the Company:

          Miravant Medical Technologies
          7408 Hollister Avenue
          Santa Barbara, CA 93117
          Attention: Gary S. Kledzik
          Facsimile: (805) 685-2959

          with copy to:

          Nida & Maloney, a Professional Corporation
          800 Anacapa Street
          Santa Barbara, CA 93101
          Attention: Joseph E. Nida, Esq.
          Facsimile: (805) 568-1955



if to the Purchaser:

          _____________________________
          _____________________________
          _____________________________
          Attention:
          Facsimile:

If to any other Purchaser, to such address set forth under such Purchaser's 
name on the signature page hereto executed by such Purchaser. Each party 
shall provide notice to the other parties of any change in address.

     8.7  Successors and Assigns.  This Agreement shall be binding upon and 
inure to the benefit of the parties and their successors and assigns. Neither 
the Company nor any Purchaser shall assign this Agreement or any rights or 
obligations hereunder without the prior written consent of the other. 
Notwithstanding the foregoing, each Purchaser may assign its rights and 
obligations hereunder to any of its "affiliates," as that term is defined 
under the Securities Act, without the consent of the Company so long as such 
affiliate is an accredited investor (within the meaning of Regulation D under 
the Securities Act) and agrees in writing to be bound by this Agreement. This 
provision shall not limit each Purchaser's right to transfer the Securities 
pursuant to the terms of this Agreement or to assign such Purchaser's rights 
hereunder to any such transferee.  In that regard, if Purchaser sells all or 
part of its Common Shares to someone that acquires the shares subject to 
restrictions on transferability (other than restrictions, if any, 


<PAGE>

arising out of the transferee's status as an affiliate of the 
Company), Purchaser shall be permitted to assign its rights hereunder, in 
whole or in part, to such transferee.

     8.8  Third Party Beneficiaries.  This Agreement is intended for the 
benefit of the parties hereto and their respective permitted successors and 
assigns and is not for the benefit of, nor may any provision hereof be 
enforced by, any other person.

     8.9  Survival.  The representations and warranties of the Company and 
the agreements and covenants shall survive the closing hereunder 
notwithstanding any due diligence investigation conducted by or on behalf of 
Purchaser. The Company agrees to indemnify and hold harmless each Purchaser 
and each of each Purchaser's officers, directors, employees, partners, agents 
and affiliates for loss or damage arising as a result of or related to any 
breach or alleged breach by the Company of any of its representations or 
covenants set forth herein, including advancement of expenses as they are 
incurred. The representations and warranties of the Purchaser shall survive 
the Closing hereunder and each Purchaser shall indemnify and hold harmless 
the Company and each of its officers, directors, employees, partners, agents 
and affiliates for any loss or damage arising as a result of the breach of 
such Purchaser's representations and warranties.

     8.10  Public Filings: Publicity.  As soon as practicable following 
Closing, the Company shall issue a press release with respect to the 
transactions contemplated hereby. The Company and each Purchaser shall have 
the right to approve before issuance any press releases, SEC or NASDAQ (or 
other exchange) filings, or any other public statements with respect to the 
transactions contemplated hereby (which approval shall not be unreasonably 
withheld or delayed); provided, however, that the Company shall be entitled, 
without the prior approval of any Purchaser, to make any press release or 
SEC, NASDAQ, NASD or exchange filings with respect to such transactions as is 
required by applicable law and regulations (although the Company shall make 
all reasonable efforts to consult with each Purchaser in connection with any 
such press release prior to its release and shall provide each Purchaser with 
a copy thereof).

     8.11  Further Assurances.  Each party shall do and perform, or cause to 
be done and performed, all such further acts and things, and shall execute 
and deliver all such other agreements, certificates, instruments and 
documents, as the other party may reasonably request in order to carry out 
the intent and accomplish the purposes of this Agreement and the consummation 
of the transactions contemplated hereby.

     8.12 Remedies.  No provision of this Agreement providing for any remedy 
to a Purchaser shall limit any remedy which would otherwise be available to 
such Purchaser at law or in equity. Nothing in this Agreement shall limit any 
rights a Purchaser may have with any applicable federal or state securities 
laws with respect to the investment contemplated hereby.  The Company 
acknowledges that a breach by it of its obligations hereunder will cause 
irreparable harm to a Purchaser.  Accordingly, the Company acknowledges that 
the remedy at law for a material breach of its obligations under this 
Agreement will be inadequate and agrees, in the event of a breach or 
threatened breach by the Company of the provisions of this Agreement, that a 
Purchaser shall be entitled, in addition to all other available remedies, to 
an injunction restraining any breach and requiring immediate compliance, 
without the necessity of showing economic loss and without any bond or other 
security being required.

     8.13 Final Agreement.  This Agreement, when executed by the parties 
hereto, shall constitute the final agreement between the parties and upon 
such execution the Purchaser and the Company accept the terms hereof and have 
no cause of action against each other for prior negotiations preceding the 
execution of this Agreement.

     IN WITNESS WHEREOF, the undersigned Purchaser and the Company have 
caused this Agreement to be duly executed as of the date first above written.


<PAGE>

PURCHASER:

________________________________


By:_____________________________
     Name:
     Title:

Aggregate  Number Of Common Shares:  __________

Date:  ____________, 1997



COMPANY:

MIRAVANT MEDICAL TECHNOLOGIES:


By:_______________________________________
Name:     Gary S. Kledzik
     Title:    Chief Executive Officer

Date:  ____________, 1997
Exhibit A
To
Securities Purchase Agreement


STOCK PURCHASE WARRANT

Exhibit B
To
Securities Purchase Agreement


REGISTRATION RIGHTS AGREEMENT

Exhibit C
To
Securities Purchase Agreement


LOCK-UP AGREEMENT

Exhibit D
To
Securities Purchase Agreement


<PAGE>

This LOCK-UP AGREEMENT ("Agreement") is entered into as of __________, 1997, 
by and between MIRAVANT MEDICAL TECHNOLOGIES, a Delaware corporation (the 
"Company"), and _______________________________ (the "Purchaser").

RECITALS

A.   The Company, Purchaser and certain other purchasers signatory thereto 
("Other Purchasers") are executing and delivering the Securities Purchase 
Agreement dated as of even date herewith (the "Purchase Agreement"). 
Capitalized terms used and not defined herein shall have the meanings given 
to such terms in the Purchase Agreement.

B.   The Company, Purchaser and the Other Purchasers are executing and 
delivering the Registration Rights Agreement dated as of even date herewith 
("Registration Rights Agreement").

C.   As a condition to issuing the Common Stock to Purchaser pursuant to the 
Purchase Agreement, the Company requires that Purchaser enter into this 
Agreement.

AGREEMENTS

NOW, THEREFORE, in consideration of their respective promises contained 
herein and in the Purchase Agreement and for other good and valuable 
consideration, the receipt and sufficiency of which are hereby acknowledged, 
the Company and Purchaser hereby agree as follows:

ARTICLE I
RESTRICTIONS ON SALE OF COMMON
STOCK

1.1  Restriction on Dispositions.  Except as provided in Section 1.2, or 
except for any option transaction permitted pursuant to Section 4.10 of the 
Purchase Agreement, prior to the Termination Date (as defined below) 
Purchaser shall not, directly or indirectly, offer, sell, transfer, assign, 
contract to sell or otherwise dispose of (any such action, a "Disposition") 
any Common Shares or Warrant Shares acquired by and beneficially owned  by 
Purchaser pursuant to the Purchase Agreement.  A pledge of any such shares of 
Common Stock shall not constitute a Disposition hereunder if effected in 
compliance with Section 4.11 of the Purchase Agreement.
   
1.2  Permitted Dispositions. Upon and following the date that the Common 
Shares are registered pursuant to the Registration Rights Agreement, and 
prior to the Termination Date, Purchaser shall be permitted to effect 
Dispositions of Common Shares and Warrant Shares if the weighted average bid 
price for shares of Common Stock during the ten (10) trading days immediately 
preceding the date of such Disposition (as reported by Bloomberg, L.P.) is 
equal to or greater than $70.00 (such amount to be adjusted from time to 
time to reflect the effect of any stock dividends, stock splits, reverse 
stock splits discounted equity offerings or actions similar to any of the 
foregoing), in an amount not to exceed, individually and in the aggregate 
among the Purchasers signatory hereto, the greater of (i) ten percent (10%) 
of the ten (10) day average trading volume (as reported by Bloomberg, L.P.) 
on the date prior to the date of Disposition or (ii) on any trading day in 
which the trading volume of the Common Stock (as reported by Bloomberg, L.P.) 
is greater than 250,000 shares, ten percent (10%) of the daily trading volume 
(as reported by Bloomberg, L.P.) on such date. 
    
1.3  Term.  The restrictions on Dispositions set forth herein shall remain in 
full force and effect until the earlier of (a) __________, 1998 or (b) the 
optional termination of the Agreement pursuant to Section 1.4 (such date of 
termination, the "Termination Date").


<PAGE>

1.4  Option to Terminate.  Notwithstanding any other provision of this 
Agreement, Purchaser shall have the unilateral right to terminate this 
Agreement if any of the following events involving the Company shall have 
been announced as pending or planned, or shall have occurred:

          (a)  A Change in Control Transaction (as defined below);

          (b)  A "going private" transaction under Rule 13e-3 promulgated 
pursuant to the Securities Exchange Act of 1934, as amended (the "Exchange 
Act");

          (c)  A tender offer by the Company under Rule 13e-4 promulgated 
pursuant to the Exchange Act;

          (d)  The Company shall (1) become insolvent; (2)  admit in writing 
its inability to pay its debts generally as they mature; (3) make an 
assignment for the benefit of creditors or commence proceedings for its 
dissolution; or (4) apply for or consent to the appointment of a trustee, 
liquidator or receiver for it or for a substantial part of its property or 
business;

          (e)  Bankruptcy, reorganization, insolvency or liquidation 
proceedings or other proceedings, or relief under any bankruptcy law or any 
law for the relief of debt shall be instituted by or against the Company, or 
the Company shall by any action or answer approve of, consent to, or 
acquiesce in any such proceedings or admit to any material allegations of, or 
default in answering a petition filed in any such proceedings.

          (f)  Any member of management of the Company subject to a lock-up 
agreement pursuant to Section 4.14 of the Purchase Agreement shall sell or 
dispose of shares of Common Stock in violation of the provisions of such 
Section 4.14.

     As used in this Agreement, a "Change of Control Transaction" shall mean, 
(i) the sale, conveyance or disposition of all or substantially all of the 
assets of the corporation, (ii) a consolidation or merger of the Company with 
or into any other "Person" (whether or not the Company is the surviving 
Person, but other than a merger or consolidation whereby the stockholders of 
the Company immediately preceding the merger or consolidation continue to 
own, in such merger or consolidation, greater than 50% of the voting power of 
the capital stock of the surviving Person that is normally entitled to vote 
in the election of directors, managers or trustees, as applicable), or, (iii) 
any person or any "group" (as such term is used in Section 13(d) of the 
Exchange Act), becomes the beneficial owner or is deemed to beneficially own 
(as described in Rule 13d-3 under the Exchange Act without regard to the 
60-day exercise period) in excess of 30% of the Company's voting power of the 
capital stock of the Company normally entitled to vote in the election of 
directors of the Company.

ARTICLE II
LEGEND; REMOVAL

     2.1  Legends.  Purchaser understands that, subject to Section 2.2 
hereof, until the earlier of (a) such time as the Common Shares and Warrant 
Shares acquired by Purchaser pursuant to the Purchase Agreement are subject 
to a permitted Disposition in accordance with the terms of Section 1.2 
hereof, or (b) the Termination Date, the certificates for the Common Shares 
and Warrant Shares will bear a restrictive legend (the "Stock Legend") in the 
following form:

THE SECURITIES REPRESENTED BY THIS CERTIFICATE MAY NOT BE SOLD, TRANSFERRED, 
ASSIGNED OR DISPOSED OF, EXCEPT IN ACCORDANCE WITH THE TERMS OF THE LOCK-UP 
AGREEMENT DATED AS OF __________, 1997 ("LOCK-UP AGREEMENT") AMONG MIRAVANT 
MEDICAL TECHNOLOGIES AND THE PURCHASER PARTIES THERETO.  A TRUE AND CORRECT 
COPY OF THE LOCK UP AGREEMENT IS AVAILABLE  FROM THE COMPANY UPON REQUEST.


<PAGE>

     2.2  Removal of Legend.  The Stock Legend shall be removed and the 
Company shall issue a certificate without such Stock Legend to the holder 
("Holder") of any Security upon which it is stamped, and a certificate for a 
security shall be originally issued without the Stock Legend, if such holder 
provides a certificate in the form attached to this Agreement as Exhibit A (a 
"Disposition Certificate"), (a) designating the number of Securities from 
which holder requests that the Stock Legend be removed and (b) certifying 
that Disposition of the Securities specified in such Disposition Certificate 
is permitted pursuant to Section 1.2 of this Agreement.   Notwithstanding 
anything in this Section 2.2 or any other Section of this Agreement to the 
contrary, the Stock Legend shall be removed from all of the Common Shares and 
Warrant Shares on, and shall not be placed on Warrant Shares on and after, 
the Termination Date. In order to effect issuance of a certificate without 
the Stock Legend a Holder shall:  (a) fax (or hand deliver) a copy of the 
fully executed Disposition Certificate to the Company (unless the Termination 
Date has occurred) and (b) surrender the certificates representing the Common 
Shares or Warrant Shares to be delegended and the original Disposition 
Certificate (if applicable) as soon as practicable thereafter.  Upon receipt 
by the Company of the fax copy of a Disposition Certificate, the Company 
shall, no later than the later of (x) the third business day following such 
receipt or (y) the first business day following the date of receipt of the 
certificates representing the Common Shares or Warrant Shares and the 
original Disposition Certificate, issue and deliver to the Holder (or at its 
direction) (i) the number of unlegended shares to be issued pursuant to the 
Disposition Certificate and (ii) a certificate representing the number of 
Common Shares or Warrant Shares, if any, from which the Stock Legend is not 
being removed.   No Disposition Certificate is required to be submitted in 
connection with removal of the Stock Legend at the Termination Date.  The 
person or persons entitled to receive unlegended Common Shares or Warrant 
Shares issuable pursuant to a Disposition Certificate under this Section 2.2 
shall be treated for all purposes as the record holder of such unlegended 
shares at the close of business on the date of the Disposition Certificate 
submitted with respect thereto.

2.3  Transfer Agent Instructions.  The Company shall irrevocably instruct its 
transfer agent to issue certificates, registered in the name of each 
Purchaser or its nominee, for the Common Shares and Warrant Shares. Such 
certificates shall bear the Stock Legend only to the extent provided by 
Sections 2.1 and 2.2 above. The Company covenants that no instruction other 
than such instructions referred to in this Section 2.3 (and instructions 
relating to compliance with the Securities Act as provided in Section 5.2 of 
the Purchase Agreement) will be given by the Company to its transfer agent 
and that the Common Shares and Warrant Shares shall otherwise be freely 
transferable on the books and records of the Company.  On the earlier to 
occur of (a) receipt by the Company of a duly executed Disposition 
Certificate, or (b) the Termination Date so required by Section 2.2 the 
Company shall, subject to applicable laws affecting the transfer of 
securities, permit the transfer, and, promptly instruct its transfer agent to 
issue within the time period specified in Section 2.2 one or more 
certificates without the Stock Legend in such name and in such denomination 
as specified by such Purchaser.  The Company acknowledges that a breach by it 
of its obligations hereunder will cause irreparable harm to a Purchaser by 
vitiating the intent and purpose of the transaction contemplated hereby and 
by the Purchase Agreement. Accordingly, the Company acknowledges that the 
remedy at law for a breach of its obligations under this Section 2 will be 
inadequate and agrees, in the event of a breach or threatened breach by the 
Company of the provisions of this Section 2, that a Purchaser shall be 
entitled, in addition to all other available remedies, to an injunction 
restraining any breach and requiring immediate issuance and transfer, without 
the necessity of showing economic loss and without any bond or other security 
being required.  In addition and not in lieu of the foregoing remedies, if 
the Company fails to be issue Common Shares or Warrant Shares without the 
Stock Legend within three (3) trading days of the date when such issuance is 
required pursuant to Section 2.2 hereof (the "Required Issuance Date"), the 
Company shall pay to Purchaser an amount equal to two percent (2%) of the 
purchase price paid for the Common Shares and Warrant Shares required to be 
issued for the first month or 30 days following the Required Issuance Date, 
and three percent (3%) of said purchase price for each month or thirty (30) 
days thereafter, continuing through the date the Common Shares and Warrant 
Shares are issued without the Stock Legend.  These payments will be prorated 
on a daily basis for partial months and will be paid to the Purchaser in cash 
within five (5) business days following the earlier of:  (i) 

<PAGE>

the end of each month following the Required Issuance Date, or (ii) the date 
of issuance of the unlegended shares.

2.4  Dispute Resolution.  If there is a dispute as to Purchaser's calculation 
of the number of Common Shares and Warrant Shares properly subject to a 
Disposition Certificate, the Company shall proceed with the issuance of  the 
number of unlegended Common Shares not in dispute.  The matter shall then, 
within two (2) business days, be submitted by the Company to an accounting 
firm mutually acceptable to the Company and Purchaser for resolution, and 
such firm shall issue a determination of the proper calculation within three 
(3) business days of submission.  The calculation of such accounting firm 
shall be final and binding on the parties.  If the accounting firm determines 
that any of the disputed Common Shares or Warrant Shares were not 
appropriately subject to a Disposition Certificate under Section 1.2 
("Non-Disposable Shares"), the Company shall be relieved of its obligation to 
pay damages accruing pursuant to Section 2.3 during the dispute solely with 
respect to such Non-Disposable Shares.

ARTICLE III
MISCELLANEOUS

3.1  Governing Law: Jurisdiction.  This Agreement shall be governed by and 
construed in accordance with the Delaware General Corporation Law (in respect 
of matters of corporation law) and the laws of the State of California (in 
respect of all other matters) applicable to contracts made and to be 
performed in the State of California. The parties hereto irrevocably consent 
to the jurisdiction of the United States federal courts and state courts 
located in the County of New Castle in the State of Delaware or the County of 
Santa Barbara in the State of California in any suit or proceeding based on 
or arising under this Agreement or the transactions contemplated hereby and 
irrevocably agree that all claims in respect of such suit or proceeding may 
be determined in such courts. The Company and each Purchaser irrevocably 
waives the defense of an inconvenient forum to the maintenance of such suit 
or proceeding in such forum. The Company and each Purchaser further agrees 
that service of process upon the Company or such Purchaser, as applicable, 
mailed by the first class mail in accordance with Section 3.5 shall be deemed 
in every respect effective service of process upon the Company and such 
Purchaser in any suit or proceeding arising hereunder. Nothing herein shall 
affect Purchaser's right to serve process in any other manner permitted by 
law. The parties hereto agree that a final non-appealable judgment in any 
such suit or proceeding shall be conclusive and may be enforced in other 
jurisdictions by suit on such judgment or in any other lawful manner.  The 
parties hereto irrevocably waive any right to a trial by jury under 
applicable law.

3.2  Counterparts.  This Agreement may be executed in two or more 
counterparts, including, without limitation, by facsimile transmission, all 
of which counterparts shall be considered one and the same agreement and 
shall become effective when counterparts have been signed by each party and 
delivered to the other party. In the event any signature page is delivered by 
facsimile transmission, the party using such means of delivery shall cause 
additional original executed signature pages to be delivered to the other 
parties.

3.3  Headings.  The headings of this Agreement are for convenience of 
reference and shall not form part of, or affect the interpretation of, this 
Agreement.

3.4  Severability.  If any provision of this Agreement shall be invalid or 
unenforceable in any jurisdiction, such invalidity or unenforceability shall 
not affect the validity or enforceability of the remainder of this Agreement 
or the validity or enforceability of this Agreement in any other jurisdiction.

3.5  Notice.   Any notice herein required or permitted to be given shall be 
in writing and may be delivered in accordance with the terms of Section 8.6 
of the Purchase Agreement.

<PAGE>

3.6  Successors and Assigns.  This Agreement shall be binding upon and inure 
to the benefit of the parties and their successors and assigns. Neither the 
Company nor any Purchaser shall assign this Agreement or any rights or 
obligations hereunder without the prior written consent of the other. 
Notwithstanding the foregoing, each Purchaser may assign its rights and 
obligations hereunder to any of its "affiliates," as that term is defined 
under the Securities Act, without the consent of the Company so long as such 
affiliate is an accredited investor (within the meaning of Regulation D under 
the Securities Act) and agrees in writing to be bound by this Agreement. 

3.7  Third Party Beneficiaries.  This Agreement is intended for the benefit 
of the parties hereto and their respective permitted successors and assigns 
and is not for the benefit of, nor may any provision hereof be enforced by, 
any other person.

3.8   Further Assurances.  Each party shall do and perform, or cause to be 
done and performed, all such further acts and things, and shall execute and 
deliver all such other agreements, certificates, instruments and documents, 
as the other party may reasonably request in order to carry out the intent 
and accomplish the purposes of this Agreement and the consummation of the 
transactions contemplated hereby.

3.9  Remedies.  No provision of this Agreement providing for any remedy to a 
Purchaser shall limit any remedy which would otherwise be available to such 
Purchaser at law or in equity. Nothing in this Agreement shall limit any 
rights a Purchaser may have with any applicable federal or state securities 
laws with respect to the investment contemplated hereby.

     3.10 Future Benefits.  Purchaser will receive the identical, pro rata 
benefit offered to other purchasers entering into substantially similar 
Lock-Up Agreements with the Company as of the date hereof in the event the 
Company terminates such other agreements or otherwise waives, refrains from 
enforcing, favorably modifies or amends, or otherwise provides benefits to 
such other purchasers thereunder.

[Signatures to Follow]

IN WITNESS WHEREOF, the undersigned Purchaser and the Company have caused this
Lock-Up Agreement to be duly executed as of the date first above written.

MIRAVANT MEDICAL  TECHNOLOGIES


By:________________________________________
      Name:    Gary S. Kledzik
      Title:   Chief Executive Officer

Date:  __________, 1997




PURCHASER:

_________________________________


By:______________________________
Name:

<PAGE>

Title:

Date:     October ___, 1997

EXHIBIT  A

DISPOSITION CERTIFICATE


[DATE]

Via Facsimile & Overnight Courier

Mr. Gary S. Kledzik
Chief Executive Officer
John Philpott
Chief Financial Officer
Miravant Medical Technologies
7408 Hollister Avenue
Santa Barbara, CA 93117

[TRANSFER AGENT NAME]
[ADDRESS]

Joseph E. Nida, Esq.
Nida & Maloney, a Professional Corporation
800 Anacapa Street
Santa Barbara, CA 93101

Gentlemen:

Pursuant to Section 1.2 of the Lock-Up Agreement dated as of October ___, 
1997 (the "Lock-Up Agreement") entered into by and between Miravant Medical 
Technologies (the "Corporation") and the undersigned registered holder of the 
Corporation's common stock (the "Holder"), Holder hereby irrevocably elects 
to effect the "Disposition" (as that term is defined in the Lock-Up 
Agreement) of __________________________________ (________) shares of the 
Corporation's common stock (the "Shares"), as represented by stock 
certificate No(s). _______________________________ copies of which 
certificate(s) are attached for your reference and the originals thereof 
which shall be delivered to you together with the original of this 
Disposition Certificate.

By Holder's signature below, Holder certifies that the Disposition of Shares 
requested hereby is made in accordance with Section 1.2 of the Lock-Up 
Agreement insofar as:
   
(i)  the weighted average bid price of the Corporation's common stock (as 
reported by Bloomberg, L.P.) over the Ten (10) trading days immediately 
preceding the date of this Disposition Certificate has been equal or greater 
than $70.00; and

(ii)  the number of Common Shares set forth above which the undersigned 
intends to dispose of hereby does not exceed the greater of:

      (a)  five percent (5%) of the ten (10) day average trading volume of 
the Corporation's common stock (as reported by Bloomberg, L.P.) on the date 
prior to this Disposition Certificate; and

      (b)  five percent (5%) of the daily trading volume of the Corporation's 
common stock (as reported by Bloomberg, L.P.) on the date of this Disposition 
Certificate, if and only if such daily trading volume is greater than 250,000 
common shares.
    

<PAGE>

In accordance with the foregoing and Section 2.2 of the Lock-Up Agreement, 
please re-issue, within the time period specified in the Lock-Up Agreement, 
the number of Shares indicated above to the undersigned without the "Stock 
Legend" (as defined in the Lock-Up Agreement), at the delivery address and in 
the denominations indicated below.

If you have any questions, please call me.

Very truly yours,

_______________________________


By:____________________________
     Name:
     Title:

Address for Delivery of Shares:

______________________________
______________________________
______________________________
Attention:



Please issue Shares in the form of ___________ certificates each representing
___________ common shares.



<PAGE>

                                     EXHIBIT 23.1
                           CONSENT OF INDEPENDENT AUDITORS
   
   We consent to the reference to our firm under the caption "Experts" in 
Amendent No. 1 to the Registration Statement (Form S-3 No. 333-39905) and 
related Prospectus of Miravant Medical Technologies for the registration of up
to 3,540,000 shares of its common stock and to the incorporation by reference 
therein of our report dated February 5, 1997, with respect to the consolidated
financial statements of Miravant Medical Technologies included in its Annual
Report (Form 10-K) for the year ended December 31, 1996, filed with the 
Securities and Exchange Commission. 

Woodland Hills, California
December 4, 1997                              /s/  ERNST & YOUNG LLP
                                               -------------------------
                                                   ERNST & YOUNG LLP

    


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