MIRAVANT MEDICAL TECHNOLOGIES
8-K, 1999-01-22
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM 8-K

                                 CURRENT REPORT
                       PURSUANT TO SECTION 13 OR 15(D) OF
                       THE SECURITIES EXCHANGE ACT OF 1934


       Date of Report (Date of earliest event reported): January 15, 1999


                          MIRAVANT MEDICAL TECHNOLOGIES
             (Exact name of registrant as specified in its charter)



     Delaware                         0-25544               77-0222872
 (State or other jurisdiction of    (Commission     (IRS Employer Identification
  incorporation)                    File Number)                  Number)
                       ----------------------------------

                              7408 Hollister Avenue
                         Santa Barbara, California 93117
               (Address of principal executive offices) (Zip Code)
- ------------------------------------------------------------------------ 


Registrant's telephone number,  including area code: (805) 685-9880


                N/A
(Former Name or Former Address, if Changed Since Last Report)




ITEM 5.  Other Events

     On January 15, 1999, Miravant Medical Technologies ("Miravant"),  Pharmacia
& Upjohn,  Inc. and Pharmacia & Upjohn S.p.A.  which involve these  entities and
certain other wholly owned subsidiaries  (collectively "P&U, Inc.") entered into
an Equity Investment  Agreement (the "Equity Investment  Agreement") pursuant to
which P&U, Inc. will  purchase from Miravant  1,136,533  shares of Common Stock,
par value $.01 per share,  of Miravant  (the  "Common  Stock") for an  aggregate
purchase price of $19 million.  The price of $16.71 per share includes a premium
of  approximately  20% over the ten (10) day average per share  closing price of
the Common Stock  through  January 14,  1999,  the last trading day prior to the
date  of the  Equity  Investment  Agreement.  The  Equity  Investment  Agreement
contemplates that Miravant and certain wholly owned subsidiaries of P&U, Inc., a
global,  innovation-driven  pharmaceutical  and health care company,  will enter
into  certain  other  agreements,  including  a Credit  Agreement  (the  "Credit
Agreement")  in  the  form  attached  as an  exhibit  to the  Equity  Investment
Agreement,  pursuant to which,  among other things, a wholly owned subsidiary of
P&U,  Inc.  will extend to Miravant  up to  $22,500,000  in credit to be used to
support  Miravant's  ophthalmology  program  as  well as for  general  corporate
purposes.  In  connection  with the  extension of this credit,  P&U, Inc. or its
wholly  owned  subsidiaries  will  receive a total of up to 360,000  warrants to
purchase  Common Stock of Miravant.  The exercise  price of each warrant will be
equal to 140% of the average of the closing  prices of the Common  Stock for the
ten (10)  trading  days  immediately  preceding  the  borrowing  request for the
related  loan.  Additionally,  Miravant  and  Pharmacia & Upjohn AB ("P&U AB") a
wholly owned  subsidiary of P&U, Inc.,  will amend their existing  ophthalmology
development  and  license  agreement.  The  closing  of  the  Equity  Investment
Agreement and related  transactions are subject to the satisfaction or waiver of
certain  conditions,  including but not limited to the termination or expiration
of  the  applicable  waiting  period  under  the   Hart-Scott-Rodino   Antitrust
Improvements Act of 1976, as amended.  The Equity  Investment  Agreement and the
exhibits thereto have been filed as exhibits to this Report and are incorporated
herein  by  reference.  The  following  description  of  the  Equity  Investment
Agreement and the other agreements to be entered into in connection therewith is
qualified in its entirety by reference to such exhibits.


THE EQUITY INVESTMENT AGREEMENT

     Under the  Equity  Investment  Agreement,  P&U,  Inc.  will  purchase  from
Miravant 1,136,533 shares of Common Stock for an aggregate purchase price of $19
million.  Prior to the earliest of (i) the occurrence of an Event of Default (as
defined in the Credit Agreement), (ii) the commencement of a tender offer by any
person or entity,  other than P&U, Inc. or any of its wholly owned subsidiaries,
for shares of Common Stock, or (iii) July 1, 2000, unless specifically requested
in advance by Miravant's  Board of  Directors,  neither P&U, Inc. nor any of its
affiliates  will, and P&U, Inc. and its affiliates  will not assist or encourage
others (including by providing financing) to, directly or indirectly, acquire or
agree,  offer,  seek or propose to acquire ownership of any securities issued by
Miravant (including but not limited to beneficial  ownership (as defined in Rule
13d-3 under the Securities Exchange Act of 1934)) or enter into any discussions,
negotiations, arrangements or understandings with any person with respect to any
of the  foregoing;  however  that  such  provision  shall not  prohibit  (i) the
acquisition  by P&U,  Inc.  and its  affiliates  of a number of shares of Common
Stock which,  taken  together  with the number of shares of Common Stock held by
the wholly owned  subsidiary  of P&U,  Inc. as lender (the  "Lender")  under the
Credit Agreement,  and its affiliates as of the date of such  acquisition,  does
not exceed 25% of the  outstanding  Common Stock,  (ii) the  acquisition by P&U,
Inc.  or its  affiliates  of shares  of  Common  Stock  pursuant  to the  Credit
Agreement or upon exercise of any Warrants (as defined in the Credit Agreement),
or (iii) the  acquisition by P&U, Inc. or its affiliates of promissory  notes or
any other securities  pursuant to the Credit Documents (as defined in the Credit
Agreement).

     The Equity Investment  Agreement will terminate  certain  provisions of the
existing  Restated and Amended  Development  and License  Agreement for SnET2 in
oncology and urology  between  Miravant and P&U S.p.A.,  which would require P&U
S.p.A.  to make  certain  reimbursements  of  development  costs to Miravant and
provides for the amendment of the Amended And Restated Ophthalmology Development
& License Agreement as described below.

     Pursuant to the Registration Rights Agreement attached as an exhibit to the
Equity Investment Agreement,  P&U S.p.A. will be granted certain "piggyback" and
demand  registration  rights,  for up to  three  registration  statements,  with
respect  to the shares of Common  Stock  acquired  under the  Equity  Investment
Agreement.


THE AMENDING AGREEMENT AND THE CARDIOVASCULAR RIGHT OF FIRST NEGOTIATION

     The Equity Investment Agreement  contemplates that Miravant and P&U AB will
enter  into an  Amended  and  Restated  Ophthalmology  Development  and  License
Agreement in the form attached as an exhibit to the Equity Investment  Agreement
(the  "Amending  Agreement").  Pursuant to the Amending  Agreement,  P&U AB will
assume  control of the clinical and regulatory  aspects of the joint  ophthalmic
programs of Miravant and P&U AB,  including the  PhotoPoint(TM)  drug SnET2 (tin
ethyl  etiopurpurin)  which is in Phase  III  clinical  trials  for  age-related
macular  degeneration  ("AMD").  P&U AB will also assume  responsibility for the
manufacturing  scale-up of SnET2 to commercial  levels.  The Amending  Agreement
will  amend  the  agreement  executed  in July  1995 and  subsequently  amended,
pursuant  to  which  Miravant  and  P&U AB  agreed  to  co-develop,  market  and
distribute SnET2 for indications in ophthalmology.  The Amending  Agreement will
terminate  certain  provisions of such  agreement  which would require P&U AB to
make certain milestone payments to Miravant for AMD and will require Miravant to
account  for the  costs  to be  borne  by P&U AB in  respect  of its  additional
clinical  and  regulatory  responsibilities  under the  Amending  Agreement  and
liquidity to be provided pursuant to the Credit Agreement from future royalties.

     On January 15, 1999, Miravant and P&U, Inc. entered into a letter agreement
(the  "Cardiovascular  Right  of  First  Negotiation")  which  provides  that if
Miravant develops SnET2 in the field of  cardiovascular  medicine (the "Field"),
P&U, Inc. or its subsidiaries  will have a right of first negotiation to acquire
exclusive  marketing  rights to SnET2 in the Field.  Miravant and P&U, Inc. will
contemplate  conducting a feasibility  evaluation concerning SnET2 in the Field.
If a  definitive  agreement is executed by the parties in the Field,  P&U,  Inc.
will have a right of first negotiation for other drug compounds in the Field.


THE CREDIT AGREEMENT

     The Equity Investment  Agreement  contemplates that Miravant and the Lender
will enter into the Credit Agreement  pursuant to which the Lender will agree to
extend to Miravant,  for use in support of Miravant's  ophthalmology program and
for general corporate  purposes,  an aggregate amount not to exceed $22,500,000,
in the form of up to six quarterly term loans.

     Loans.  If requested by Miravant  not more than once in each  quarter,  the
Lender  will make a term loan  (each,  a "Loan")  in a  principal  amount not to
exceed the Maximum Quarterly Amount.  "Maximum  Quarterly Amount" means, (i) for
the quarter comprising January,  February and March, 1999, $3,750,000,  and (ii)
for any other quarter (the  "Reference  Quarter"),  the sum of  $3,750,000  plus
either (A) if and only if no Loan was made in the quarter immediately  preceding
the Reference  Quarter or the  principal  amount of the Loan made in the quarter
immediately  preceding the Reference Quarter was less than $3,750,000,  then the
amount equal to the amount by which  $3,750,000  exceeds the principal amount of
the Loan,  if any,  made in the  quarter  immediately  preceding  the  Reference
Quarter,  or (B) if and only if the  principal  amount  of the Loan  made in the
quarter immediately preceding the Reference Quarter was equal to or greater than
$3,750,000, then zero.

     Warrants.  Miravant  will issue to P&U,  Inc.  or one of its  wholly  owned
subsidiaries,  in respect of each $62.50 in principal  amount of loans  extended
under the Credit  Agreement,  one warrant to purchase  one share of Common Stock
having the terms set forth in the  Warrant  Agreement  attached as an exhibit to
the Equity  Investment  Agreement.  If  Miravant  borrows  the full  $22,500,000
available  under the Credit  Agreement,  P &U, Inc.  or one of its wholly  owned
subsidiaries  will acquire a total of 360,000  warrants.  The exercise  price of
each warrant  will be equal to 140% of the average of the closing  prices of the
Common Stock for the ten (10) trading days  immediately  preceding the borrowing
request for the related loan.  The warrants also contain a provision  whereby if
and only if the average of the closing prices of the Common Stock for the thirty
(30) trading days  immediately  preceding a particular date exceeds the exercise
price of one or more warrants, Miravant shall be entitled to cause the holder of
such warrants to exercise all of the related warrants.  The warrants will expire
on the fifth  anniversary  of the first  borrowing  made  pursuant to the Credit
Agreement.

     Interest.  Each Loan shall bear  interest  at a rate per annum equal to the
prime  commercial  loan rate from time to time  publicly  announced by Citibank,
N.A. in the City of New York (the "Base  Rate"),  which rate shall change as and
when the Base Rate  changes.  Interest  is  payable  quarterly  in  arrears  and
interest due prior to January 1, 2001 shall be payable by a promissory  note (an
"Interest  Note")  evidencing  an  additional  loan made  pursuant to the Credit
Agreement,  having a principal amount equal to the amount of such interest,  and
bearing interest at the Base Rate.  Interest due subsequent to December 31, 2000
shall be payable only in cash;  provided  that if and only if EBITDA (as defined
in the Credit  Agreement) for the calendar quarter does not exceed the amount of
interest due, then, subject to the next sentence, such interest shall be payable
by an Interest Note.  Miravant shall not be entitled to pay interest on Loans by
an  Interest  Note in respect of  interest  payable on any of the four  quarters
immediately following the closing of a primary offering or sale of securities in
which the net  available  proceeds to Miravant from such offering or sale equals
or exceeds $5,000,000.

     Repayment. The aggregate outstanding principal of the Loans shall be repaid
in  full,  together  with  any  accrued  interest,  not  later  than  the  fifth
anniversary of the borrowing date for the first Loan made pursuant to the Credit
Agreement (the  "Maturity  Date").  Repaid Loans may not be  reborrowed.  On the
Maturity  Date,  the Borrower may, at its option,  repay all or a portion of the
principal,  together  with any accrued  interest,  by  delivering to the Lender,
among other things, (i) shares of Common Stock (the "Repayment Shares") equal to
the product of (A) the  portion of the  aggregate  principal  of the Loans to be
repaid,  together with accrued interest (the "Share Repayment Amount"),  divided
by (B) the  average of the closing  prices of the Common  Stock for the ten (10)
trading days  immediately  preceding the Maturity  Date; and (ii) funds equal to
the difference of (A) the aggregate principal amount of the Loans, together with
accrued interest, minus (B) the Share Repayment Amount.

     Prepayment.  Miravant  may  prepay  portions  of  the  Loans  in  aggregate
principal  amounts of  $1,000,000  or integral  multiples  of $100,000 in excess
thereof,  together  with  accrued  interest on the  principal of the Loans being
repaid. Miravant will be obligated to apply to prepayment of the Loans a portion
of the net available proceeds to Miravant from any asset disposition (subject to
certain  exceptions),  a portion of the net available  proceeds to Miravant from
any offering or sale of securities,  and a portion of the amount by which EBITDA
in any calendar quarter exceeds a specified amount.

     Negative  Covenants.  The Credit  Agreement will  restrict,  and in certain
cases  prohibit,  Miravant and its  subsidiaries  from taking certain actions or
entering into certain  designated  transactions  including,  but not limited to,
mergers,  consolidations  or share  exchanges,  acquiring or disposing of any of
their assets, incurring or assuming certain indebtedness, declaring dividends or
purchasing,  acquiring, redeeming or retiring capital stock or other securities,
entering into sale and leaseback  transactions and entering into any transaction
with any affiliate or related person of Miravant or any of its subsidiaries.  In
addition,  the Credit Agreement will restrict Miravant and its subsidiaries from
amending, modifying or waiving any provision of the License Agreement, effective
July 1, 1989, between the University of Toledo, the Medical College of Ohio, St.
Vincent  Medical  Center  and  Miravant  or  the  Development  and  Distribution
Agreement, dated May 28, 1996, between Iridex Corporation and Miravant.

     Affirmative and Financial Covenants. The Credit Agreement will require that
Miravant meet certain affirmative and financial conditions,  including,  but not
limited to, specified  levels of Shareholders'  Equity (as defined in the Credit
Agreement),  the maintenance of designated financial ratios, limits on Operating
Losses (as defined in the Credit  Agreement) in years 1999 and 2000, and minimum
spending  requirements  for  Ophthalmology  expenses  (as  defined in the Credit
Agreement) in years 1999 and 2000.

     Events of Default. The Credit Agreement will provide that if one or more of
the Events of  Default,  specified  therein,  then,  and at any time  during the
continuance  of such Event of  Default,  the Lender  may,  by written  notice to
Miravant,  declare any Loans then outstanding to be due, whereupon the principal
of the loans made under the Credit  Agreement  so declared  to be due,  together
with accrued  interest  thereon and any unpaid amounts  accrued under the Credit
Documents, shall become forthwith due.

     In addition to those  occurrences  which  customarily  constitute events of
default under loan  agreements,  the Credit  Agreement  also provides that there
will be an Event of Default if (j) any  person or group of persons  (within  the
meaning of Section 13 or 14 of the Securities Exchange Act of 1934, as amended),
other than the Lender and its  affiliates  and other than any person or group of
persons which has beneficial  ownership of 5% or more of the outstanding  shares
of Common  Stock as of the date of the Credit  Agreement,  shall  have  acquired
beneficial  ownership  (within  the  meaning  of Rule 13d-3  promulgated  by the
Securities  and  Exchange  Commission  under  said  Act) of 19.9% or more of the
outstanding  shares of Common  Stock;  or,  during any period of 24  consecutive
calendar months,  individuals who were directors of Miravant on the first day of
such period  shall cease to  constitute  a majority of the board of directors of
Miravant.

     Security.  The payment and performance of Miravant's  obligations under the
Credit  Agreement  will be  secured by the  Miravant's  grant to the Lender of a
security  interest in and to  substantially  all of Miravant's real and personal
property.


Item 7. Exhibits


Exhibit
Number                                      Exhibit

10.1     Equity Investment Agreement dated January 15, 1999 between the 
         Registrant and Pharmacia & Upjohn, Inc., and Pharmacia & Upjohn, S.p.A.
                  
10.2     Credit Agreement between the Registrant and the Lender.

10.3     Warrant Agreement between the Registrant and Pharmacia & Upjohn, Inc.

10.4     Security Agreement between the Registrant and the Secured Party.

10.5     Registration Rights Agreement between the Registrant and Pharmacia & 
         Upjohn, Inc.

10.6     Amended and Restated Ophthalmology Development & License Agreement 
         between the Registrant and Pharmacia & Upjohn AB.

10.7     Cardiovascular Right of First Negotiation between the Registrant and 
         Pharmacia & Upjohn, Inc.









                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                          MIRAVANT MEDICAL TECHNOLOGIES


                                By:/s/John M. Philpott          
                                --------------------------------------
                                      John M. Philpott
                                      Chief Financial Officer

Date:    January 22, 1999





                                INDEX TO EXHIBITS


Exhibit
Number                                      Exhibit

10.1     Equity Investment Agreement dated January 15, 1999 between the 
         Registrant and Pharmacia & Upjohn, Inc., and Pharmacia & Upjohn, S.p.A.
                  
10.2     Credit Agreement between the Registrant and the Lender.

10.3     Warrant Agreement between the Registrant and Pharmacia & Upjohn, Inc.

10.4     Security Agreement between the Registrant and the Secured Party.

10.5     Registration Rights Agreement between the Registrant and Pharmacia & 
         Upjohn, Inc.

10.6     Amended and Restated Ophthalmology Development & License Agreement 
         between the Registrant and Pharmacia & Upjohn AB.

10.7     Cardiovascular Right of First Negotiation between the Registrant and 
         Pharmacia & Upjohn, Inc.




                          EQUITY INVESTMENT AGREEMENT


     EQUITY  INVESTMENT  AGREEMENT (this  "Agreement"),  dated as of January 15,
1999,  between  Miravant  Medical  Technologies,  a  Delaware  corporation  (the
"Company"),  Pharmacia & Upjohn, Inc., a Delaware corporation (the "Purchaser"),
and Pharmacia & Upjohn, S.p.A., an Italian corporation.

                              W I T N E S S E T H :


     WHEREAS,  the Company and  Affiliates  of the  Purchaser are parties to the
Restated  and Amended  Development  and License  Agreement,  dated June 8, 1998,
between  Pharmacia  & Upjohn  S.p.A.  and the  Company  (the  "Oncology  License
Agreement"),  and the Amended and Restated Ophthalmology Development and License
Agreement,  dated June 8, 1998,  between  Pharmacia  & Upjohn AB and the Company
(the  "Ophthalmology  License Agreement" and, together with the Oncology License
Agreement,  the  "License  Agreements"),  and the  parties  desire to amend such
License Agreements in certain respects, as contemplated herein; and

     WHEREAS,  certain  subsidiaries  of the  Purchaser are the record owners of
shares of Common Stock (as  hereinafter  defined),  and the Purchaser  wishes to
acquire  additional  shares of Common Stock, all on the terms and subject to the
conditions set forth in this Agreement.

     NOW, THEREFORE, the parties agree as follows:


                                    ARTICLE I

                                   Definitions


                                                     
     Section I.1. Terms  Generally.  The  definitions  ascribed to terms in this
Agreement  apply  equally to both the  singular  and plural forms of such terms.
Whenever  the context may  require,  any pronoun  shall be deemed to include the
corresponding  masculine,  feminine  and  neuter  forms.  The  words  "include",
"includes"  and  "including"  shall be  interpreted as if followed by the phrase
"without limitation". All references herein to the Preamble, Recitals, Articles,
Sections and Schedules shall be deemed  references to the Preamble and Recitals,
Articles and Sections of, and  Schedules to, this  Agreement  unless the context
shall  otherwise  require.  The headings and captions  herein shall not be given
effect in interpreting or construing the provisions of this Agreement. Except as
otherwise expressly provided herein, all references to "dollars" or "$" shall be
deemed references to the lawful money of the United States of America.

     Section I.2. Definitions. The following terms have the meanings ascribed to
them below:

     "Act" has the meaning assigned to such term in Section 6.03.

     "Affiliate"  means any other  Person  directly or  indirectly  controlling,
controlled by, or under common control with, that Person.

     "Agreement" has the meaning assigned to such term in the preamble hereto.

     "Amending  Agreement"  has the meaning  assigned to such term  specified in
Section 7.01.

     "Associate"  has the meaning  ascribed to such term in Rule 12b-2 under the
1934 Act.

     "Audited  Financial  Statements"  has the meaning  assigned to such term in
Section 4.10.

     "Business Day" means any day that is not a Saturday, Sunday or other day on
which  commercial  banks in The City of New York or in Los Angeles,  California,
are authorized by law to close.

     "Certificate   of   Incorporation"   means  the  Restated   Certificate  of
Incorporation of the Company as in effect on the Closing Date.

     "Closing" has the meaning assigned to such term in Section 3.02.

     "Closing Date" has the meaning assigned to such term in Section 3.02.

     "Commission" means the Securities and Exchange Commission.

     "Common Stock" means the common stock, $.01 par value, of the Company.

     "Company" has the meaning assigned to such term in the Preamble.

     "Control,"  "controlled  by" or "under common control with" means direct or
indirect  possession of the power to direct or cause the direction of management
or policies  (whether  through  ownership of voting  securities,  by contract or
otherwise); provided that control shall be conclusively presumed when any Person
directly or indirectly owns a majority of the securities  having ordinary voting
power for the election of a majority of the directors of a corporation.

     "Credit Agreement" has the meaning assigned to such term in Section 7.01.

     "Disclosure  Package"  has the  meaning  assigned  to such term in  Section
4.09(a).

     "Employee  Benefit  Plan" has the meaning  assigned to such term in Section
4.18.

     "Environmental Law" has the meaning assigned to such term in Section 4.22.

     "Environmental  Property" has the meaning  assigned to such term in Section
4.22.

     "FDA" has the meaning assigned to such term in Section 4.24.

     "Hazardous  Materials"  has the  meaning  assigned  to such term in Section
4.22.

     "Intellectual  Property  Rights" has the  meaning  assigned to such term in
Section 4.14.

     "License  Agreements"  has the  meaning  assigned to such term in the first
Recital.

     "Licenses  and  Permits"  means  all   governmental  and  private  permits,
licenses,  certificates of occupancy,  franchises and authorizations required to
conduct the business of the Company and its  Subsidiaries  with  operations  and
products substantially the same as those of the Company immediately prior to the
consummation of the transaction contemplated hereby or as now contemplated.
                 
     "Loss" means any loss, claim, damages, or liability.

     "Oncology  License  Agreement" has the meaning assigned to such term in the
first Recital.

     "Ophthalmology  License Agreement" has the meaning assigned to such term in
the first Recital.

     "Person"  means  and  includes  natural  persons,   corporations,   limited
liability companies,  limited partnerships,  general  partnerships,  joint stock
companies,   joint   ventures,   associations,   companies,   trusts   or  other
organizations,  whether or not legal entities,  and governments and agencies and
political subdivisions thereof.

     "Product  Intellectual  Property" has the meaning  assigned to such term in
Section 4.13.

     "Purchase Price" has the meaning assigned to such term in Section 3.01.

     "Purchaser" has the meaning assigned to such term in the Preamble.

     "Registration  Rights  Agreement" has the meaning  assigned to such term in
Section 7.01.

     "Securities" has the meaning assigned to such term in Section 3.01.

     "Security Agreement" has the meaning specified in Section 7.01.

     "Subsidiary" means any corporation, association or other business entity of
which more than 50% of the total  voting  power or shares of stock  entitled  to
vote in the election of directors,  managers or trustees  thereof is at the time
owned or controlled,  directly or  indirectly,  by the Company or one or more of
the other Subsidiaries of the Company or a combination thereof.

     "Warrant Agreement" has the meaning assigned to such term in Section 7.01.

     "1933 Act" means the  Securities  Act of 1933,  as amended and as it may be
amended from time to time, including the rules and regulations thereunder.

     "1934 Act" means the Securities  Exchange Act of 1934, as amended and as it
may  be  amended  from  time  to  time,  including  the  rules  and  regulations
thereunder.


                                   ARTICLE II

                      Amendments to the License Agreements

     Section II.1.  Amendment to the Oncology  License  Agreement.  The Oncology
License Agreement is hereby amended ab initio, effective as of the Closing Date,
to delete therefrom Section 3.04 thereof in its entirety.

     Section II.2. Amendment to Ophthalmology  License Agreement.  When executed
and delivered as  contemplated  hereby,  the Amending  Agreement  will amend the
Ophthalmology  License  Agreement in certain  respects,  all as set forth in the
Amending Agreement.


                                   ARTICLE III

                                Equity Investment

     Section III.1. Issuance,  Sale and Delivery of the Securities.  The Company
hereby  agrees,  subject to the prior  satisfaction  or waiver in writing by the
Company of the  conditions  specified in Section  7.02, to issue and sell to the
Purchaser, and the Purchaser hereby agrees, subject to the prior satisfaction or
waiver in writing by the Purchaser of the conditions  specified in Section 7.01,
to  purchase   from  the  Company,   1,136,533   shares  of  Common  Stock  (the
"Securities")  for  an  aggregate  purchase  price  equal  to  $19,000,000  (the
"Purchase Price").


     Section III.2.  Closing. The consummation of the stock purchase transaction
contemplated by Section 3.01 shall take place at Sullivan & Cromwell,  125 Broad
Street, New York, New York 10004, at 10:00 a.m., New York time, on the fifth day
following the  satisfaction or waiver by the Purchaser in writing of the last to
be satisfied or so waived of the conditions set forth in Article VII, or at such
other  location,  date and time as may be agreed upon between the  Purchaser and
the Company (such consummation being called the "Closing" and such date and time
being called the "Closing Date"). At the Closing, (a) the Company shall deliver,
issue and sell to the Purchaser a stock  certificate or certificates in the name
of the Purchaser or any Affiliate of the Purchaser  designated to the Company by
the Purchaser,  representing the Securities, and (b) the Purchaser shall pay the
Purchase Price by wire transfer or certified or bank cashier's check in same day
funds.


                                   ARTICLE IV

                  Representations and Warranties of the Company

     The Company hereby makes the following representations and warranties which
shall  survive the  execution  and delivery of this  Agreement and the issuance,
delivery and sale of the Securities pursuant hereto:

     Section IV.1. Organization and Qualification.  The Company is a corporation
duly  organized,  validly  existing and in good  standing  under the laws of the
State of Delaware and is duly  qualified to do business in  California.  Neither
the  Company  nor any of its  stockholders  has  adopted  or taken any action in
contemplation  of any plan of liquidation  or  dissolution  of the Company.  The
Company has provided the Purchaser with true, complete and correct copies of the
Certificate of Incorporation  and Bylaws of the Company as in effect on the date
hereof.

     Section IV.2. Corporate Power of the Company. The Company has the requisite
corporate  power and authority to execute,  deliver and carry out this Agreement
and all other instruments,  documents and agreements contemplated or required by
the provisions of this Agreement to be executed, delivered or carried out by the
Company.  The Company has all requisite  corporate power and authority under the
laws of the jurisdiction of its  incorporation to own and operate its properties
and to carry on its business as now  conducted  and as presently  proposed to be
conducted. The Board of Directors and stockholders of the Company have taken all
necessary  corporate  action to approve  this  Agreement  and to  authorize  the
execution,  delivery and  performance  of this  Agreement  by the  Company,  the
issuance  by  the  Company  of  the  Securities  and  the  consummation  of  the
transactions contemplated hereby. This Agreement has been duly properly executed
and  delivered  by the Company  and  constitutes  the legally  valid and binding
obligation of the Company enforceable against it in accordance with its terms.

     Section IV.3. No Conflict.  Except as set forth in Schedule  4.03,  none of
(a) the approval by the Board of Directors  and  stockholders  of the Company of
this  Agreement,  (b) the  execution  or the  delivery  by the  Company  of this
Agreement or the performance by the Company of its obligations  hereunder or the
consummation of the transactions  contemplated hereby or (c) the issuance by the
Company of the  Securities  will (A) conflict with or result in any violation or
constitute a default under the  Certificate  of  Incorporation  or Bylaws of the
Company or any  agreement,  mortgage,  indenture,  franchise,  license,  permit,
authorization, lease or other instrument, or any judgment, decree, order, law or
regulation by which the Company or any of its properties or assets is bound,  or
(B) result in the creation or imposition of any lien, security interest, charge,
encumbrance,  restriction  or claim of any  nature  upon,  or give to others any
interest or right,  including any right of  termination or  cancellation,  in or
with respect to, or otherwise adversely affect, any property,  asset or business
of the  Company,  or (C)  require  the  Company  to obtain or make any  consent,
authorization,  approval, registration, declaration or filing under any statute,
law, ordinance,  regulation, rule, judgment, decree or order of any court or any
governmental agency,  board, bureau, body, department or authority of any United
States or foreign  jurisdiction,  except those which have been  completed at the
date of this Agreement,  or (D) conflict with any other  restriction of any kind
or character  to which the Company is subject or to which any of its  properties
is bound.

     Section IV.4.  Subsidiaries.  The Company has three Subsidiaries,  Miravant
Cardiovascular, Inc., a Delaware corporation, Miravant Pharmaceuticals,  Inc., a
Delaware corporation, and Miravant Systems, Inc., a California corporation. Each
Subsidiary is duly incorporated, validly existing and in good standing under the
laws of its  jurisdiction  of  incorporation,  and has all  corporate  power and
authority to carry on its business as now conducted and as presently proposed to
be conducted. All of the outstanding capital stock of the Company's Subsidiaries
is validly issued,  fully paid and  nonassessable  and owned by the Company free
and  clear of any  lien,  pledge  or other  encumbrance.  Other  than the  three
Subsidiaries,  the  Company  does  not own any  securities  or  other  ownership
interests in any other  Person  which would  entitle the Company to control such
Person.

                          Section IV.5. Capitalization.

     (a) Authorized  Shares.  The authorized  capital of the Company consists of
50,000,000  shares of Common Stock and 20,000,000  shares of preferred stock, of
which 500,000 shares have been designated  Series A Preferred Stock. The Company
holds no shares of its  capital  stock in its  treasury.  Except as set forth in
Schedule  4.05(a) and except as disclosed in the Disclosure  Package,  no Person
has any  agreement,  subscription,  option  or  warrant  or any  other  right or
commitment  entitling  such Person to acquire from the Company any shares of the
Company's capital stock or any other securities or other instruments convertible
into or exchangeable for any such shares.

     (b) Outstanding  Shares. At the Closing,  no more than 17,200,000 shares of
capital  stock  of the  Company  will  be  issued  and  outstanding.  All of the
Securities  when issued,  sold and delivered in accordance with the terms hereof
and for the consideration  expressed herein,  will have been duly authorized and
validly  issued,  fully  paid  and  non-assessable  and  free  of any  liens  or
encumbrances.  The issuance of the Securities will not violate any preemptive or
other  rights  and will be in  compliance  with  applicable  federal  and  state
securities  laws and  regulations.  The Company has no obligations or agreements
concerning the repurchase of any of the shares of its outstanding capital stock.

     Section IV.6.  Corporate  Record  Keeping.  The corporate  record and stock
transfer  books  of the  Company  and  each of its  Subsidiaries  are  complete,
accurate and up-to-date with all necessary signatures and set forth all meetings
and actions taken by the respective incorporators, stockholders and directors of
each such party.

     Section  IV.7.   Compliance   With  Laws.  The  Company  and  each  of  its
Subsidiaries is in compliance in all material respects with all federal,  state,
local and foreign statutes,  laws, ordinances,  regulations,  rules,  judgments,
orders  and  decrees  applicable  to it or its  respective  assets,  properties,
business or operations.

     Section  IV.8.  Licenses and Permits.  The Company is not aware of any fact
which has not been disclosed to the Purchaser which could  adversely  affect the
ability of the Company to obtain or maintain  the  Licenses  and Permits (or any
consent  required  to be  obtained  with  respect  thereto  as a  result  of the
transactions   contemplated  hereby)  after  consummation  of  the  transactions
contemplated  hereby on the same terms as such Licenses and Permits were held by
the  Company   immediately   prior  to  the  consummation  of  the  transactions
contemplated hereby.

                            Section IV.9. Disclosure.

     (a) The Company has delivered to the  Purchaser  copies of the filings made
by the Company with the Commission since December 31, 1995 and prior to the date
hereof and the press releases issued by the Company since September 30, 1998 and
prior to the date hereof  (such  filings and press  releases  collectively,  the
"Disclosure Package").

     (b) To the Company's knowledge,  none of such statements,  forms or reports
(including, without limitation, any financial statements, exhibits and schedules
included therein and documents incorporated therein by reference), as amended or
supplemented, if applicable, at the time filed, declared effective or mailed, as
the case may be, contained any untrue statement of a material fact or omitted to
state any material fact  required to be stated  therein or necessary to make the
statements therein not misleading.

     (c) This  Agreement and all of the Schedules  delivered to the Purchaser in
connection  herewith,  when read together with the  Disclosure  Package,  do not
contain any statement  that is false or misleading  with respect to any material
fact and do not omit to state a  material  fact  necessary  in order to make the
statements therein not false or misleading. There is no additional fact of which
the Company is aware that has not disclosed in writing to the Purchaser  that in
the opinion or belief of the Company materially and adversely affects, or so far
as the Company can now reasonably  foresee will materially and adversely affect,
the properties, business or condition (financial or otherwise) of the Company or
any Subsidiary.

     Section  IV.10.  Financial  Statements.  The Company has  furnished  to the
Purchaser a true and complete copy of its audited  consolidated balance sheet as
of  December  31,  1997 and an  audited  consolidated  statement  of income  and
retained earnings for the year then ended (the "Audited Financial  Statements").
Except as disclosed in the Disclosure Package,  the Audited Financial Statements
have been prepared in accordance with generally accepted  accounting  principles
on a basis  consistent  with prior  periods  and fairly  present  the  financial
condition  and results of operations  and changes in the financial  condition of
the Company and the  Subsidiaries  as of the dates thereof,  and for the periods
indicated,  subject to all normal  adjustments.  For purposes of this Agreement,
all  references  to  "Audited  Financial  Statements"  include any notes to such
statements.

     Section IV.11. Litigation.  There is no material suit, action,  arbitration
or legal,  administrative or other proceeding or pending  investigation to which
the Company or any  Subsidiary  is a party or, to the  Company's  knowledge,  is
threatened against the Company,  or any of its Subsidiaries or their businesses,
assets or financial condition. Except as set forth in Schedule 4.11, the Company
has no knowledge of any  governmental  investigation  against the Company or its
Subsidiaries,  other than routine government contract audits. To the best of the
Company's  knowledge,  neither  the Company  nor any of its  Subsidiaries  is in
violation or infringement of any  intellectual  property right, or registrations
or applications therefor, of any other person.

     Section IV.12. Conflict of Interest.  Except as disclosed in the Disclosure
Package,   all  purchasing   transactions   relating  to  the  Company  and  its
Subsidiaries have been at market prices since inception.  No officer or director
of the Company or any  Affiliate  of any such person has or within the last year
has had, either directly or indirectly:

     (a) an equity  or debt  interest  in any  corporation,  partnership,  joint
venture,  association,  organization or other Person which furnishes or sells or
during such period  furnished or sold services or products to the Company or the
Subsidiaries,  or purchases or during such period  purchased from the Company or
the Subsidiaries any goods or services,  or otherwise does or during such period
did business with the Company or the Subsidiaries; or

     (b) a beneficial interest in any contract, commitment or agreement to which
the  Company  or the  Subsidiaries  is or was a  party  or  under  which  it was
obligated or bound or to which its  properties  may be or may have been subject,
other than stock options and other contracts,  commitments or agreements between
the  Company  or the  Subsidiaries  and  such  persons  in their  capacities  as
employees, independent contractors,  officers or directors of the Company or the
Subsidiaries.

     Section IV.13.  License Agreements and Product Intellectual  Property.  The
representations and warranties made by the Company in the License Agreements are
true and correct.  The Company has no actual  knowledge  of any suit,  claims or
proceedings pending or threatened with respect to the rights in the intellectual
property  owned  by or  licensed  to  the  Company  (the  "Product  Intellectual
Property"). To the Company's knowledge,  there are no commitments or contractual
obligations  of which the Company is a party which  would  prohibit  the Company
from entering into this  Agreement or performing  its  obligations  hereunder or
which  would  affect  the  Company's  ability to amend  with the  Purchaser  the
licenses  for the  Product  Intellectual  Property  provided  for in the License
Agreements.

                  Section IV.14.  Intellectual Property Rights.

     (a) To the Company's  knowledge  and except as disclosed in the  Disclosure
Package:  the Company and its Subsidiaries have good and marketable title to and
own their  inventions,  licenses,  patents,  trade secrets or other  proprietary
know-how (the  "Intellectual  Property Rights") free and clear of all mortgages,
liens, loans and encumbrances, except such encumbrances and liens which arise in
the ordinary  course of business and do not  materially  impair the Company's or
its  Subsidiaries'  ownership  or use of the  Intellectual  Property  Rights  or
materially  detract from the value thereof;  no proceedings have been instituted
or are pending which challenge the Company's or its Subsidiaries'  rights to the
Intellectual  Property  Rights or the validity  thereof;  all material rights or
inventions  conceived  by any  employee  or  consultant  of the  Company  or its
Subsidiaries  during  the  scope  of  their  services  for  the  Company  or its
Subsidiaries have been disclosed and effectively  assigned to the Company or its
Subsidiaries;  and with respect to the Intellectual  Property Rights licensed by
the Company and its  Subsidiaries,  such  licenses are in full force and effect,
the Company and its Subsidiaries are in compliance with the terms and provisions
thereof,  and no event has occurred which, with notice or lapse of time or both,
would  constitute  a breach or  violation  thereof  which  could have a material
adverse effect on the financial condition, business or properties of the Company
and its Subsidiaries taken as a whole, and the Company and its Subsidiaries hold
a valid license free of any liens,  claims or encumbrances which do not and will
not,  individually  or in the aggregate,  have a material  adverse effect on the
financial condition,  business or properties of the Company and its Subsidiaries
taken as a whole.

     (b) To the Company's  knowledge,  the Company and its Subsidiaries have the
right and authority to use the  Intellectual  Property Rights in connection with
the conduct of the  business of the Company and its  Subsidiaries  in the manner
and to the extent such business is presently  conducted and as it is proposed to
be conducted, and the Company and its Subsidiaries have not been notified of any
claim that such use conflicts with, infringes upon or violates any rights of any
other Person, except to the extent that such conflict, infringement or violation
does not and will not, individually or in the aggregate, have a material adverse
effect.

     Section IV.15. Material Contracts. Except as set forth on Schedule 4.15 and
except as disclosed in the Disclosure Package, there are no material agreements,
undertakings,  instruments,  contracts  or  proposed  transactions  to which the
Company  or any of the  Subsidiaries  is a party or by  which it is bound  which
involve  an  option,  license  or  agreement  of any kind  with  respect  to the
Intellectual  Property  Rights  of  the  Company  or  its  Subsidiaries,  or the
prohibition or limitation of the Company's or any of its  Subsidiaries'  ability
to engage in their  respective  businesses  or any other  business or to compete
with any Person.

     Section  IV.16.  No  Undisclosed  Liabilities.  Except as  disclosed in the
Disclosure  Package,  there are no  liabilities  or  obligations  of any nature,
whether absolute, accrued, contingent or otherwise, and whether due or to become
due  (including,  without  limitation,  any  liability  for taxes and  interest,
penalties  and other  charges  payable  with  respect to any such  liability  or
obligations)  which  individually  or in  the  aggregate  are  material  to  the
condition  (financial or otherwise) of the Company, or prospects of the Company,
which are not disclosed in the Audited Financial Statements,  or incurred in the
ordinary  course of business  subsequent to the latest of the Audited  Financial
Statements.

                Section IV.17. Changes.  Except as disclosed in the Disclosure
Package and except as set forth in Schedule 4.17 or disclosed  elsewhere in this
Agreement,  since  December 31, 1997,  except as filed with the  Commission,  or
disclosed elsewhere in this Agreement there has not been:

                  (a) any material change in the assets, liabilities (contingent
or  otherwise),  obligations,  condition  (financial  or otherwise) or operating
results of the Company or any of the  Subsidiaries,  except operating losses and
changes in the ordinary  course of business  from that  reflected in the Audited
Financial   Statements  or  subsequent   financial  statements  filed  with  the
Commission;

                  (b) any material waiver by the Company and its Subsidiaries of
a valuable  right  which is  material  to the  Company's  and its  Subsidiaries'
business or of a material debt owed to it;

                  (c) any  satisfaction  or  discharge  of any  lien,  claim  or
encumbrance  or payment of any  obligation by the Company and its  Subsidiaries,
except in the  ordinary  course of  business  and which is not  material  to the
assets,  properties,   financial  condition,  operating  results,  prospects  or
business of the  Company and its  Subsidiaries  (as such  business is  presently
conducted and as it is planned to be conducted);

                  (d) any material change or amendment to a material contract or
arrangement  by which the Company and its  Subsidiaries  or any of its assets or
properties is bound or subject; or

                  (e) any  other  material  adverse  change in the  business  or
prospects  of the Company and its  Subsidiaries  (as such  business is presently
conducted or planned to be conducted).

               Section  IV.18.   Employee   Benefit   Plans.   No  prohibited
transaction (as defined under Section 4975 of the Internal Revenue Code of 1986,
as amended) has occurred. The Company has received a favorable  determination of
qualification  from the Internal  Revenue Service for each employee benefit plan
(as  defined  in  Section  3(3) of  ERISA)("Employee  Benefit  Plan")  in  which
employees  of  the  Company  or  the  Subsidiaries  participate.  The  financial
statements of the Company accurately reflect all liabilities owed by the Company
to past  and  present  employees  or  their  beneficiaries  arising  out of such
employees'  employment with the Company pursuant to such Employee Benefit Plans.
All amounts  required under the terms of any Employee  Benefit Plan to have been
paid or accrued as contributions to such Employee Benefit Plan by the Company as
of the last day of the most  recent  fiscal year of such Plan ended on or before
the date of this Agreement have been paid or accrued.

                  Section IV.19. Employee Relations. The Company is not bound by
or subject to (and none of its assets or  properties  is bound by or subject to)
any written or oral,  express or implied,  contract,  commitment or  arrangement
with any labor union,  and no labor union has  requested or, to the knowledge of
the Company, sought to represent any of the employees, representatives or agents
of the  Company or any of its  Subsidiaries.  There is no strike or other  labor
dispute  involving  the Company or any of its  Subsidiaries  pending,  or to the
knowledge of the Company threatened,  which could have a material adverse effect
on the assets,  properties,  financial condition,  prospects or business (as now
conducted or as proposed to be  conducted)  of the  Company,  nor is the Company
aware of any labor  organization  activity  involving  its or its  Subsidiaries'
employees.  The Company is not aware that any officer or key employee intends to
terminate his or her employment with the Company or any of its Subsidiaries, nor
does the Company  intend to terminate  the  employment  of any such person.  The
Company believes its relations with its employees are satisfactory.

                  Section IV.20. Taxes. All required foreign, federal, state and
local tax returns,  notices and reports of the Company and its Subsidiaries have
been accurately  prepared and duly and timely filed,  and all foreign,  federal,
state,  local and other taxes  required  to be paid with  respect to the periods
covered by such  returns  have been paid,  except  such  returns  and taxes with
respect to which the  failure  to pay or file would not have a material  adverse
effect.  The  Company  has never had any tax  deficiency  proposed  or  assessed
against it which would have a material  adverse  effect,  has not  executed  any
waiver  or  extension  of  any  statute  of  limitations  on the  assessment  or
collection of any taxes which would have a material  adverse  effect and none of
the Company's federal or state tax returns has ever been audited by governmental
authorities. No tax audit, action, suit, proceeding, investigation,  examination
or claim is now pending or, to the Company's  knowledge,  threatened against the
Company,  and no issue or question has been  communicated to the Company (and is
currently  pending)  by any  taxing  authority  in  connection  with  any of the
Company's tax returns or reports.

     Section IV.21. Use of Proceeds.  The proceeds of the sale of the Securities
to the Purchaser  hereunder shall be used by the Company for working capital and
other general corporate purposes.

     Section IV.22. Environmental Matters. To the Company's best knowledge after
reasonable inquiry:

                  (a) all assets and  property  currently or  previously  owned,
leased, operated or used by the Company or any of the Subsidiaries in connection
with their  businesses  ("Environmental  Property"),  all current  and  previous
conditions  on and  uses  of the  Environmental  Property  and all  current  and
previous ownership and operations of the Environmental  Property and the Company
and the Subsidiaries (including, without limitation, transportation and disposal
of Hazardous  Materials by or for the Company or the Subsidiaries)  comply, have
at all times  complied,  and will comply  with,  and do not cause,  and have not
caused,  liability to be incurred by the Company or the  Subsidiaries  under any
current or past federal or state law relating to the protection of health or the
environment, including, without limitation, the common law, including the law of
nuisance and strict liability  ("Environmental Law") except where non-compliance
has had and will have no material  adverse  effect;  and neither the Company nor
any  of  the   Subsidiaries  is  in  violation  of  and  has  not  violated  any
Environmental  Law  which  violation  has had or will  have a  material  adverse
effect;

                  (b) the Company has  properly  obtained  and is in  compliance
with all necessary  permits,  registrations,  approvals  and  licenses,  and has
properly  made all  filings  with and  submissions  to any  government  or other
authority,  required  by any  Environmental  Law the failure of which to obtain,
comply with or make would have a material adverse effect.  No deficiencies  have
been  asserted by any such  government  or authority  with respect to such items
which deficiencies have had or will have a material adverse effect; and

                (c)  there  has  been no  spill,  discharge,  leak,  leaching,
emission, migration, injection, disposal, escape, dumping or release of any kind
on, beneath,  above or into the  Environmental  Property or into the environment
surrounding the  Environmental  Property of any (i) pollutants or  contaminants,
other  than  automobile  emissions,   (ii)  hazardous,   toxic,   infectious  or
radioactive  substances,  chemicals,  materials  or wastes  (including,  without
limitation,  those  defined as hazardous  under any  Environmental  Law),  (iii)
petroleum  including  crude oil or any  derivative  or  fraction  thereof,  (iv)
asbestos  fibers,  other than contained in automobile brake linings or (v) solid
wastes ((i)-(v) collectively, "Hazardous Materials") which have had or will have
a material adverse effect.

                  Section IV.23.  Registration Rights;  Voting Trust Agreements.
Except as described in the Disclosure Package, the Company is not a party to any
contract or  commitment  which  requires the Company to register  (now or in the
future,  whether contingent or not) under the 1933 Act any of its capital stock.
The Company is not a party to, nor aware of, any stockholder agreements,  voting
trusts, proxies or other agreements or understandings with respect to the voting
of any of the capital stock of the Company.

                  Section  IV.24.  FDA  Matters.  Except  as  disclosed  to  the
Purchaser in writing,  there are no applications or other proceedings  presently
pending before the United States Food and Drug  Administration  (the "FDA"). The
FDA has not delivered a letter of  non-approval  or threatened to deliver such a
letter with respect to any product manufactured, marketed, licensed or developed
by the  Company  or any  Subsidiary,  or any  product  which the  Company or its
Subsidiaries intend to manufacture, market, license or develop.

     Section  IV.25.  Warranties  and  Representations.  All  of  the  foregoing
representations  and  warranties  will survive for a period of one year from the
Closing Date.


                                    ARTICLE V

                                    Covenants

                  The Company covenants and agrees that so long as the Purchaser
and its Affiliates own more than 5% of the outstanding shares of Common Stock of
the Company, unless the Purchaser shall otherwise consent in writing, it will:

     Section V.1. Financial Information. Furnish or cause to be furnished to the
Purchaser the following  financial  statements and  information,  which shall be
prepared on a substantially consistent basis:

                (a) As soon as  available  but in any  event  within  100 days
after the close of each fiscal year of the Company, audited consolidated balance
sheets of the  Company and of each of its  Subsidiaries  as of the close of such
fiscal year, and audited consolidated statements of income, stockholders' equity
and cash flow of the Company and each of its  Subsidiaries for such fiscal year,
prepared in accordance with generally accepted  accounting  principles,  setting
forth,  in  the  case  of  each  consolidated  balance  sheet  and  consolidated
statement,  in comparative form,  corresponding figures for the preceding fiscal
year,  together with copies of the reports and  certificates  relating  thereto,
including an opinion of Ernst & Young LLP or other independent  certified public
accountants of recognized national standing selected by the Company. The Company
and the Purchaser  agree that so long as the Company is subject to the reporting
obligations  of Section 13 of the 1934 Act pursuant to Section 12(b) or 12(g) of
the 1934  Act,  the  Company's  Annual  Report on Form 10-K  shall  satisfy  the
requirements of this Section 5.01(a).

                  (b) As soon as available but in any event within 60 days after
the end of each fiscal quarter of the Company (i) a  consolidated  balance sheet
of the Company and its  Subsidiaries  as of the last day of such fiscal  quarter
and  consolidated  statements of income and cash flow of the Company and each of
its  Subsidiaries  for such quarter and for the period from the beginning of the
then  current  fiscal  year  to the  end  of  such  quarter,  setting  forth  in
comparative  form  corresponding  figures for the same quarter and period in the
preceding  fiscal year and for the same  quarter and period in the current  year
and  (ii) a  consolidating  balance  sheet  for  the  Company  and  each  of its
Subsidiaries  as of the close of such quarter and  consolidating  statements  of
earnings  and cash flow for the  Company and each of its  Subsidiaries  for such
quarter and for the period from the beginning of the then current fiscal year to
the end of such  quarter,  each balance sheet and statement of earnings and cash
flow  referred to in this  Section to be certified  by the  principal  financial
officer of the Company,  provided that any such  certificate  may state that the
accompanying  balance  sheet and  statements  are  subject  to  normal  year-end
adjustments based on year-end audit. The Company and the Purchaser agree that so
long as the Company is subject to the reporting obligations of Section 13 of the
1934 Act  pursuant  to  Section  12(b) or 12(g) of the 1934 Act,  the  Company's
Quarterly  Report on Form 10-Q shall  satisfy the  requirements  of this Section
5.01(b).

                (c)  From  time to  time,  with  reasonable  promptness,  such
additional  financial  statements and information  with respect to the financial
condition of the Company and of its Subsidiaries as the Purchaser may reasonably
request,  including,   without  limitation  and  without  further  request,  any
financial  statements  or reports  (including  comment  letters  to  management)
furnished to the Company or any Subsidiary by its independent  certified  public
accountants,  any and all registration statements, proxy statements and periodic
reports filed by the Company or any Subsidiary  with the Commission  pursuant to
the 1933 Act or the 1934 Act, and all material  press  releases  issued by or on
behalf of the Company or any Subsidiary.

                  Section V.2. Access to Information.  Provide such  information
concerning the operations of the Company and its  Subsidiaries  as the Purchaser
may from time to time reasonably request in writing, and upon reasonable advance
notice  permit  representatives  of the  Purchaser  full and free access  during
normal  business hours to the  properties,  books and records of the Company and
its  Subsidiaries;  provided  that the Company shall not be required to disclose
any  confidential  information  or  information  held as a trade secret,  and to
discuss  the  affairs,  accounts  and  finances  of  the  Company  or any of its
Subsidiaries with the financial and management  personnel of the Company and its
Subsidiaries and with their independent certified public accountants.

                  Section V.3. Board of Directors' Meetings. The Purchaser shall
receive  notices of any and all Board of Directors'  meetings in accordance with
the Bylaws of the Company and shall be entitled to attend,  as an observer,  all
such Board of  Directors'  meetings.  In addition,  the Company will provide the
Purchaser  with copies of any written  consents of the Board of Directors at the
time they are signed by the Board of Directors.

                  Section  V.4.  Rule 144.  The Company  agrees to make and keep
public information regarding the Company available as those terms are understood
and defined in Rule 144  promulgated  under the 1933 Act, at all times following
the  date  of the  Company's  initial  public  offering,  and to file  with  the
Commission  in a timely manner all reports and other  documents  required of the
Company  under the 1933 Act and the 1934 Act,  at any time that it is subject to
such reporting requirements.


                                 ARTICLE VI

           Representations, Warranties and Covenants of the Purchaser;
                             Transfer of Securities

     Section  VI.1.  Representations  of the  Purchaser.  The  Purchaser  hereby
represents  and  warrants  to the  Company  as follows:

                  (a) The Purchaser is a corporation organized under the laws of
Delaware having its principal place of business in Bridgewater, New Jersey.

                  (b)  The  Purchaser  has the  requisite  corporate  power  and
authority  to  execute,  deliver  and  carry  out this  Agreement  and all other
instruments, documents and agreements contemplated or required by the provisions
of this  Agreement  to be executed,  delivered or carried out by the  Purchaser.
This  Agreement  constitutes  the legally  valid and binding  obligation  of the
Purchaser enforceable against the Purchaser in accordance with its terms.

                  (c) The  Purchaser  is an  "accredited  investor"  within  the
meaning of Regulation D under the 1933 Act, and is acquiring the  Securities for
investment  for its own account,  and not with a view to  distribution  subject,
nevertheless,  to any  requirement  of law that the  disposition of its property
shall at all times be within its control.  The Purchaser has such  knowledge and
experience  in financial  and business  matters that it is capable of evaluating
the merits and risks of purchasing the  Securities.  The Purchaser is aware that
it may be required to bear the economic risk of an investment in the  Securities
for an  indefinite  period,  and it is able to bear such risk for an  indefinite
period. The Purchaser  acknowledges (a) that the Securities being acquired by it
are not being  registered under the 1933 Act on the grounds that the issuance of
such securities is exempt from  registration  under Section 4(2) of the 1933 Act
as not involving  any public  offering,  and (b) that the Company's  reliance on
such exemption is predicated in part on the representations  made to the Company
by the Purchaser in this Section 6.01.

     Section VI.2.  Transfer of Securities.  The Purchaser will not sell, assign
or transfer all or any part of the Securities acquired by it except as follows:

                 (a) The Securities or any part thereof or interest therein may
be assigned or  transferred to an Affiliate of the Purchaser for its own account
or in connection with a sale of the Purchaser or its portfolio assets;  provided
that  such  assignment  or  transfer  is  made  in  compliance  with  applicable
securities laws.

                  (b) The Securities or any part thereof or interest therein may
be assigned or  transferred  if such transfer is determined by the Purchaser and
its counsel, which may be in-house counsel to the Purchaser,  to be necessary in
order to comply with applicable laws,  rules or regulations;  provided that such
assignment or transfer is made in compliance with applicable securities laws.

                  (c) The Securities or any part thereof or interest therein may
be assigned or  transferred  to any other Person or Persons;  provided  that the
Purchaser shall have furnished to the Company, if reasonably requested to do so,
either (i) an opinion,  reasonably  satisfactory to counsel for the Company,  of
counsel skilled in securities  matters (selected by the Purchaser and reasonably
satisfactory  to the Company,  it being  understood  and agreed that  Sullivan &
Cromwell is and will be  reasonably  satisfactory  to the Company) to the effect
that the proposed  sale or transfer may be made without  registration  under the
1933 Act, or (ii) an interpretive  letter from the Commission to the effect that
no  enforcement  action will be  recommended if the proposed sale or transfer is
made  without  registration  under the 1933 Act, in either case  accompanied  by
evidence  reasonably  satisfactory  to the Company that such transfer will be in
compliance  with  applicable  state  securities  ("blue  sky")  laws;  provided,
however, that the foregoing proviso shall not apply with respect to any transfer
pursuant to an effective registration statement under the 1933 Act.

                  Upon the assignment or transfer by the Purchaser of all or any
part of the Securities or its interest  therein  pursuant to paragraphs (a), (b)
or (c)  above,  the term  "the  Purchaser",  as used  herein,  shall  thereafter
include, to the extent of the interest so assigned or transferred,  the assignee
or transferee of such interest provided,  however,  that the foregoing shall not
apply  with  respect  to any  transfer  pursuant  to an  effective  registration
statement under the 1933 Act.

                Section  VI.3.  Private  Placement;   Legends.  The  Purchaser
acknowledges  and agrees that the Securities have not been registered  under the
1933 Act and may not be offered or sold in the United States or to U.S.  persons
(as defined in Regulation S) unless the Securities are registered under the 1933
Act,  or an  exemption  from the  registration  requirements  of the 1933 Act is
available.  Each  certificate  evidencing any Securities  shall bear a legend in
substantially the following form:

         The securities represented by this certificate are subject to an Equity
         Investment  Agreement,  dated  January 15,  1999, a copy of which is on
         file at the  principal  office of the Company and will be  furnished to
         the holder on request to the  Secretary  of the  Company.  Such  Equity
         Investment   Agreement  provides,   among  other  things,  for  certain
         restrictions  on  sale,  transfer,  pledge,   hypotheca-tion  or  other
         disposition of the securities evidenced by this certificate.

                  In addition,  unless counsel to the Company shall have advised
the Company that such legend is no longer needed,  each  certificate  evidencing
the Securities shall bear a legend in substantially the following form:

         The securities represented by this certificate have not been registered
         pursuant to the Securities Act of 1933, as amended (the "Act"),  or any
         state securities law, and such securities may not be sold,  transferred
         or otherwise  disposed of unless the same are  registered and qualified
         in accordance with the Act and any applicable state securities laws, or
         in the opinion of counsel  reasonably  satisfactory to the Company such
         registration and qualification are not required.


                  The Purchaser shall have the right to request that the Company
remove  such  legends  if the  conditions  of Rule 144 of the 1933 Act have been
satisfied with respect to the Securities  evidenced by such  certificate,  or if
such  Securities  are otherwise  registered  in accordance  with the 1933 Act or
another  exemption from such  registration  is available,  and the Company shall
fully  cooperate  with the  Purchaser  if any of the  foregoing  conditions  are
satisfied; provided in each case other than registration under the 1933 Act that
the Purchaser shall have furnished to the Company, if reasonably requested to do
so, an opinion or  interpretive  letter and such other evidence as is referenced
in Section 6.02(c) for a transfer of such Securities.


                                   ARTICLE VII

                              Conditions to Closing

                  Section VII.1. Conditions to the Purchaser's Obligations.  The
obligation of the  Purchaser to purchase the  Securities is subject to the prior
satisfaction,  or waiver in writing by the  Purchaser,  of all of the  following
conditions:

                  (a)  The   representations   and  warranties  of  the  Company
contained in Article IV shall be true in all material respects as of the Closing
Date as though made at and as of the Closing Date.

                  (b)  The  Company  shall  have  performed,   in  all  material
respects, all covenants,  agreements and obligations required to be performed by
it on or prior to the Closing Date pursuant to this Agreement.

                  (c) A Credit  Agreement in the form attached hereto as Exhibit
A (the "Credit  Agreement"),  a Warrant Agreement in the form attached hereto as
Exhibit B (the "Warrant  Agreement"),  a Security Agreement in the form attached
hereto as Exhibit C (the "Security Agreement"),  a Registration Rights Agreement
in the form attached hereto as Exhibit D (the  "Registration  Rights Agreement")
and an Amended and Restated Ophthalmology Development & License Agreement in the
form attached  hereto as Exhibit E (the  "Amending  Agreement")  shall have been
duly executed and delivered by the parties thereto.

                  (d) The  Purchaser  shall have  received the opinion of Nida &
Maloney PC in the form attached hereto as Exhibit F.

                  (e) On or prior to the Closing Date,  the Company shall tender
to the Purchaser certificate(s) representing the Securities.

                (f) The  Company and the  Purchaser  shall have  obtained  all
necessary  authorizations,  consents  or  approvals  or other  orders or actions
necessary or appropriate for the consummation of the  transactions  contemplated
by this  Agreement,  and the  Company  and the  Purchaser  shall  have  made all
necessary filings with any court,  administrative  agency, or other governmental
or regulatory  body or authority  required for the execution and delivery by the
Company and the Purchaser of this Agreement or the Company's and the Purchaser's
consummation of the transactions contemplated hereby.

                  (g) No action, suit,  proceeding or investigation by or before
any court, administrative agency or other governmental authority shall have been
instituted or threatened  which may restrain,  prohibit or invalidate any of the
transactions contemplated by this Agreement.

                  (h) The  waiting  period  (including  any  extension  thereof)
applicable to the  Purchaser's  acquisition of the  Securities  pursuant to this
Agreement under the  Hart-Scott-Rodino  Antitrust  Improvements  Act of 1976, as
amended,  shall have expired or been  terminated,  and the Purchaser  shall have
received evidence thereof satisfactory to the Purchaser.

                  Section VII.2.  Conditions to the Company's  Obligations.  The
obligation of the Company to issue,  deliver and sell the  Securities is subject
to the prior  satisfaction  or waiver in  writing  by the  Company of all of the
following conditions:

                  (a)  The  representations  and  warranties  of  the  Purchaser
contained  in Section  6.01  shall be true in all  material  respects  as of the
Closing Date as though made at and as of the Closing Date.

                  (b)  The  Purchaser  shall  have  performed,  in all  material
respects, all covenants,  agreements and obligations required to be performed by
it on or prior to the Closing Date pursuant to this Agreement.

                  (c)  The  Credit  Agreement,   Warrant   Agreement,   Security
Agreement,  Registration Rights Agreement and Amending Agreement shall have been
duly executed and delivered by the parties thereto.

                  (d) On the Closing  Date,  the  Purchaser  shall tender to the
Company the Purchase Price.

                  (e) The  Company and the  Purchaser  shall have  obtained  all
necessary  authorizations,  consents  or  approvals  or other  orders or actions
necessary or appropriate for the consummation of the  transactions  contemplated
by this  Agreement,  and the  Company  and the  Purchaser  shall  have  made all
necessary filings with any court,  administrative  agency, or other governmental
or regulatory  body or authority  required for the execution and delivery by the
Company and the Purchaser of this Agreement or the Company's and the Purchaser's
consummation of the transactions contemplated hereby.

                  (f) No action, suit,  proceeding or investigation by or before
any court, administrative agency or other governmental authority shall have been
instituted or threatened  which may restrain,  prohibit or invalidate any of the
transactions contemplated by this Agreement.

                  (g) The  waiting  period  (including  any  extension  thereof)
applicable to the  Purchaser's  acquisition of the  Securities  pursuant to this
Agreement under the  Hart-Scott-Rodino  Antitrust  Improvements  Act of 1976, as
amended,  shall have  expired or been  terminated,  and the  Company  shall have
received evidence thereof satisfactory to the Company.


                                  ARTICLE VIII

                                    Indemnity

                  Section VIII.1.  General. The Company shall indemnify,  defend
and save harmless the Purchaser  from,  against,  for and in respect of any Loss
which  arises out of or relates to (i) a state of facts as a result of which any
representation  made by the  Company  in  Article  IV hereof or in any  document
delivered pursuant to this Agreement is untrue,  inaccurate or misleading in any
respect as of the date hereof,  or (ii) the breach of any  warranty  made by the
Company  in Article IV  hereof,  or (iii) the  failure of the  Company to comply
with,  perform or observe any other term,  provision or  condition  contained in
this Agreement or in any document delivered pursuant to this Agreement;  and any
reasonable  expenses  incurred in connection  with  investigating,  defending or
asserting  any  claim,  action,  suit  or  proceeding  incident  to  any  matter
indemnified against hereunder, including, without limitation, court filing fees,
court costs, arbitration fees or costs, witness fees, and fees and disbursements
of  legal  counsel,  investigators,  expert  witnesses,  accountants  and  other
professionals in connection therewith.

                 Section VIII.2. Cooperation. Each of the parties hereto agrees
to render to the other parties such  assistance as they may  reasonably  require
and to  cooperate  in good faith  with the other  parties in order to ensure the
proper and adequate defense of any claim,  action, suit or proceeding brought by
any third party.

                  Section  VIII.3.  Remedies  Cumulative.  The  remedies  of the
parties  provided  for in this  Article  VIII  shall be  cumulative,  shall  not
preclude  the  assertion  by any party of any other  rights  such party may have
under this  Agreement,  applicable law or otherwise  (including  rescission) and
shall survive redemption or repurchase of the Securities.


                                   ARTICLE IX

                           Effectiveness of Agreement

                  Section IX.1.  General.  Except as otherwise  provided herein,
the provisions of this Agreement shall continue in full force and effect for the
benefit of the holders of the Securities so long as any shares of the Securities
are held by the Purchaser or its Affiliates.  The representations and warranties
made herein or in connection  herewith shall survive the issuance,  delivery and
sale of the Securities.


                                    ARTICLE X

                        Lockup and Standstill Agreements

                  Section X.1. Lockup. Prior to the 180th calendar day following
the Closing Date,  the Purchaser  shall not, and shall cause its  Affiliates not
to, sell, assign, transfer or otherwise dispose of any of the Securities, except
that the Purchaser may transfer any of the Securities to any of its wholly owned
subsidiaries.

                            Section X.2. Standstill.

                  (a) The Stock  Purchase  Agreement,  dated as of July 1, 1995,
between the Company and Pharmacia & Upjohn S.p.A.  is hereby  amended ab initio,
effective as of the date thereof, to delete therefrom Section 5.5 thereof in its
entirety.

                 (b) Prior to the earliest of (i) the occurrence of an Event of
Default (as defined in the Credit Agreement),  (ii) the commencement of a tender
offer by any Person,  other than  Pharmacia & Upjohn,  Inc. or any of its wholly
owned  subsidiaries,  for shares of Common Stock, and (iii) July 1, 2000, unless
specifically  requested in advance by the Company's Board of Directors,  neither
the Purchaser nor any of the Purchasers'  Affiliates will, and the Purchaser and
its  Affiliates  will not assist or  encourage  others  (including  by providing
financing) to, directly or indirectly,  acquire or agree, offer, seek or propose
to acquire ownership of any securities issued by the Company  (including but not
limited to  beneficial  ownership (as defined in Rule 13d-3 under the 1934 Act))
or enter into any discussions, negotiations, arrangements or understandings with
any Person with  respect to any of the  foregoing;  provided  that this  Section
10.02(b)  shall  not  prohibit  (i) the  acquisition  by the  Purchaser  and its
Affiliates of a number of shares of Common Stock which,  taken together with the
number of shares of Common Stock held by the Purchaser and its  Affiliates as of
the date of such  acquisition,  does not exceed 25% of the  aggregate  number of
outstanding shares of Common Stock as of the date of this acquisition,  (ii) the
acquisition  by the  Purchaser  or its  Affiliates  of shares  of  Common  Stock
pursuant  to  Section  2.03 of the  Credit  Agreement  or upon  exercise  of any
Warrants (as defined in the Credit  Agreement),  or (iii) the acquisition by the
Purchaser or its Affiliates of promissory notes pursuant to the Credit Agreement
or any other  securities  pursuant  to the Credit  Documents  (as defined in the
Credit Agreement).


                                   ARTICLE XI

                                  Miscellaneous

                  Section XI.1.  APPLICABLE  LAW. THIS  AGREEMENT AND ALL RIGHTS
ARISING HEREUNDER SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS
OF THE  STATE OF NEW  YORK  APPLICABLE  TO  CONTRACTS  MADE AND TO BE  PERFORMED
ENTIRELY WITHIN SUCH STATE.


                  SECTION  XI.2.  WAIVER OF JURY.  THE COMPANY AND THE PURCHASER
EACH HEREBY WAIVES TRIAL BY JURY IN ANY JUDICIAL PROCEEDING INVOLVING,  DIRECTLY
OR INDIRECTLY,  ANY MATTER (WHETHER SOUNDING IN TORT,  CONTRACT OR OTHERWISE) IN
ANY WAY ARISING OUT OF,  RELATED TO, OR CONNECTED  WITH THIS  AGREEMENT  AND ANY
RIGHT ARISING HEREUNDER.

                  Section XI.3.  Jurisdiction and Venue; Service of Process. (a)
The  Company  and  the  Purchaser  each  hereby   irrevocably   submits  to  the
non-exclusive  jurisdiction  of any state or  federal  court in the  Borough  of
Manhattan, The City of New York for the purpose of any suit, action,  proceeding
or judgment  relating to or arising out of this  Agreement and any right arising
hereunder,  and to the laying of venue in the Borough of Manhattan,  The City of
New York. The Company and the Purchaser each hereby  irrevocably  waives, to the
fullest extent  permitted by applicable  law, any objection to the laying of the
venue of any such suit, action or proceeding brought in the aforesaid courts and
hereby  irrevocably  waives any claim that any such suit,  action or  proceeding
brought in any such court has been brought in an inconvenient forum.

                  (b) The  Company  agrees  that  service of process in any such
action or proceeding  may be effected by mailing a copy thereof by registered or
certified mail (or any substantially  similar form of mail), postage prepaid, to
the Company at its address set forth in Section  11.06 or at such other  address
of which the Purchaser shall have been notified  pursuant  thereto.  The Company
further  agrees that nothing  herein shall affect the right to effect service of
process in any other manner  permitted by law or shall limit the right to sue in
any other jurisdiction.

                  (c)  Each of the  Company  and the  Purchaser  waives,  to the
maximum  extent not prohibited by law, any right it may have to claim or recover
in any legal action or proceeding referred to in this Section 11.03 any special,
exemplary, punitive or consequential damages.

                  Section XI.4.  Amendments and Waivers.

                  (a) Any provision of this Agreement may be amended,  modified,
supplemented  or  waived,  but only by a written  amendment  or  supplement,  or
written waiver, signed by the Company and the Purchaser.

                  (b)  Except to the extent  expressly  set forth  therein,  any
waiver  shall be effective  only in the  specific  instance and for the specific
purpose for which such waiver is given.


                  Section XI.5.  Cumulative  Rights;  No Waiver.  Each and every
right granted to the Purchaser or allowed the Purchaser by law or equity,  shall
be  cumulative  and not  exclusive  and may be exercised  from time to time.  No
failure on the part of the  Purchaser to exercise,  and no delay in  exercising,
any right  will  operate  as a waiver  thereof,  nor will any  single or partial
exercise by the  Purchaser of any right  preclude  any other or future  exercise
thereof or the exercise of any other right.

                  Section XI.6. Notices. Any communication,  demand or notice to
be given  hereunder  will be duly given when delivered in writing or by telecopy
to a party at its address as indicated below or such other address as such party
may specify in a notice to each other party hereto. A  communication,  demand or
notice given pursuant to this Section 11.06 shall be addressed:

           If to the Company, to

                           Miravant Medical Technologies
                           7408 Hollister Avenue
                           Santa Barbara, California 93117

                           Telecopy:  (805) 685-6038

                           Attention:  Gary S. Kledzik

           with a copy (which, in and of itself, shall not constitute notice) to

                           Nida & Maloney PC
                           800 Anacapa Street
                           Santa Barbara, California 93101

                           Telecopy:         (805) 568-1955

                           Attention:  Joseph E. Nida

                  and


                           Wilson Sonsini Goodrich & Rosati
                           650 Page Mill Road
                           Palo Alto, California 94304

                           Telecopy:  (650) 493-6811

                           Attention:  John T. Sheridan

                  If to the Purchaser, to

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:  (908) 470-8047

                           Attention:  Treasurer

                  and

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:  (908) 306-4485

                           Attention:  Senior Vice President
                                              of Business Development

                  and

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:  (908) 306-4489

                           Attention:  General Counsel

       with a copy (which, in and of itself, shall not constitute notice) to

                           Sullivan & Cromwell
                           125 Broad Street
                           New York, New York 10004

                           Telecopy:        (212) 558-3588
                           Attention:       Neil T. Anderson,
                                             Matthew G. Hurd
                                             and Martin J. Travers

                  (b) Unless  otherwise  provided to the  contrary  herein,  any
notice  which is required  to be given in writing  pursuant to the terms of this
Agreement may be given by telecopy.

                  Section  XI.7.  Separability.  In case  any one or more of the
provisions   contained  in  this   Agreement   shall  be  invalid,   illegal  or
unenforceable  in  any  respect  under  any  law,  the  validity,  legality  and
enforceability of the remaining provisions contained in this Agreement shall not
in any way be affected or impaired thereby.

                  Section XI.8.  Persons  Benefitting.  This Agreement  shall be
binding  upon and inure to the benefit of the  Purchaser  and the  Company,  and
their   respective   successors,   assigns,    beneficiaries,    executors   and
administrators.  Nothing in this  Agreement is intended or shall be construed to
confer upon any  Person,  other than the  Company  and the  Purchaser  (and such
successors,  assigns, beneficiaries,  executors and administrators),  any right,
remedy or claim under or by reason of this  Agreement or any part  hereof.  This
Agreement may not be assigned without the written consent of the parties hereto,
and any purported  assignment  made in violation of this provision shall be null
and void. The provisions of the previous sentence notwithstanding, the Purchaser
may assign its rights and obligations  under this Agreement to any of its wholly
owned Subsidiaries without the consent of any other party to this Agreement.

     Section XI.9. Counterparts. This Agreement may be executed in any number of
counterparts,  each of  which  shall be  deemed  an  original,  but all of which
together constitute one and the same instrument.

     Section XI.10.  Headings.  The descriptive headings of the several Sections
of this Agreement are inserted for  convenience  and shall not control or affect
the meaning or construction of any of the provisions hereof.

     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed, as of the date first above written.

                                           MIRAVANT MEDICAL TECHNOLOGIES


                                            By:________________________________
                                               Name:
                                               Title:


                                            PHARMACIA & UPJOHN, INC.


                                            By:________________________________
                                               Name:
                                               Title:


                                            PHARMACIA & UPJOHN, S.p.A.


                                            By:________________________________
                                               Name:
                                               Title:


                                                      



     CREDIT   AGREEMENT,   dated  as  of  o,  1999,   between  Miravant  Medical
Technologies,   a  Delaware  corporation  (the  "Borrower")  and  o,  a  Swedish
corporation (the "Lender").


                              W I T N E S S E T H :

     WHEREAS,  the  Borrower has  requested  the Lender to commit to lend to the
Borrower,  for general  corporate  purposes,  an aggregate  amount not to exceed
$22,500,000,  in the form of up to six term  loans,  with not more than one such
term loan to be made in each of the six  calendar  quarters  between  January 1,
1999 and June 30, 2000; and

     WHEREAS, the Lender is willing to make such loans, and the additional loans
described  in  Section  3.01(b)  hereof,  on the terms and  conditions  provided
herein;

                  NOW, THEREFORE, the parties agree as follows:


                                    ARTICLE I

                                   Definitions

     Section I.1. Definitions.

     (a) Terms  Generally.  The definitions  ascribed to terms in this Agreement
apply equally to both the singular and plural forms of such terms.  Whenever the
context may require,  any pronoun  shall be deemed to include the  corresponding
masculine,  feminine  and neuter  forms.  The words  "include",  "includes"  and
"including"  shall  be  interpreted  as  if  followed  by  the  phrase  "without
limitation".  The  phrase  "individually  or in the  aggregate"  shall be deemed
general  in scope  and not to refer to any  specific  Section  or clause of this
Agreement. All references herein to the Preamble,  Recitals, Articles, Sections,
Exhibits and Schedules shall be deemed  references to the Preamble and Recitals,
Articles and Sections of, and Exhibits and Schedules to, this  Agreement  unless
the  context  shall  otherwise  require.  The table of  contents,  headings  and
captions  herein shall not be given effect in  interpreting  or  construing  the
provisions of this Agreement. Except as otherwise expressly provided herein, all
references to "dollars" or "$" shall be deemed references to the lawful money of
the United States of America.

     (b) Accounting Terms.  Except as otherwise  expressly  provided herein, the
term  "consolidated"  and all  other  terms  of an  accounting  nature  shall be
interpreted  and  construed in  accordance  with GAAP, as in effect from time to
time; provided,  however,  that, for purposes of determining compliance with any
covenant set forth in Article VII,  such terms shall be construed in  accordance
with  GAAP  as in  effect  on the  date of this  Agreement,  applied  on a basis
consistent  with the  construction  thereof  applied in preparing the Borrower's
audited financial statements referred to in Section 5.01(h).

     (c) Other Terms.  The  following  terms have the meanings  ascribed to them
below or in the Sections of this Agreement indicated below:

     "Additional  Loans"  means,  collectively,  Loans made  pursuant to Section
3.01(b).

     "Affiliate"  means,  with  respect to any  Person,  any other  Person  that
controls, is controlled by, or is under common control with, such Person.

     "Agreement" means this credit agreement, as it may be amended,  modified or
supplemented from time to time.

     "Approved  Subsidiary"  has the  meaning  assigned  to such term in Section
8.02(a).

     "Asset  Disposition"  by any Person means any transfer,  conveyance,  sale,
lease or other disposition by such Person or any of its Subsidiaries  (including
a consolidation  or merger or other sale of any such Subsidiary with, into or to
another  Person  in a  transaction  in  which  such  Subsidiary  ceases  to be a
Subsidiary,  but excluding a disposition  by a Subsidiary of such Person to such
Person or a Wholly Owned Subsidiary of such Person or by such Person to a Wholly
Owned  Subsidiary  of such  Person) of (i) shares of capital  stock  (other than
directors'  qualifying  shares) or other ownership  interests of a Subsidiary of
such Person,  (ii)  substantially all of the assets of such Person or any of its
Subsidiaries  representing  a division or line of business or (iii) other assets
or rights of such Person or any of its Subsidiaries transferred, conveyed, sold,
leased or disposed of on or  subsequent  to the date of this  Agreement for cash
consideration not in excess of, and having a book value or fair market value not
in excess of, $1,000,000 in the aggregate.

     "Assignee" has the meaning assigned to such term in Section 8.02(a).

     "Average Price" means the average of the Closing Prices of the Common Stock
for the 10 Trading Days immediately preceding the Maturity Date.

     "Base  Rate"  means,  for any day,  a rate per  annum  equal to the rate of
interest from time to time publicly  announced by Citibank,  N.A. in The City of
New York as its prime  commercial loan rate in effect on such day. The Base Rate
shall change as and when the foregoing rate shall change. Any change in the Base
Rate shall  become  effective  as of the  opening of business on the day of such
change.

     "Board of Directors" means the board of directors of the Borrower.

     "Borrower" has the meaning assigned to such term in the Preamble.

     "Borrowing Amount" has the meaning set forth in Section 2.02.

     "Borrowing  Date" means,  with respect to any Quarterly  Loan, the Business
Day set forth in the  relevant  Borrowing  Request  as the date  upon  which the
Borrower  desires to borrow such Quarterly Loan;  provided,  however,  that such
Borrowing  Date  shall be not fewer than 10  Business  Days and not more than 20
Business Days  following the Lender's  receipt of such  Borrowing  Request;  and
provided,  further,  that the  Borrowing  Date with  respect to any Loan for the
Quarter consisting of January,  February and March, 1999 may be any Business Day
not fewer than five Business Days and not more than ten Business Days  following
Lender's receipt of the Borrowing Request relating to such Loan.

     "Borrowing  Request" means a request by the Borrower for a Quarterly  Loan,
which shall specify (i) the requested  Borrowing Date, (ii) the Borrowing Amount
for such  Quarterly  Loan,  and (iii) a calculation of the Exercise Price of the
related Warrants.

     "Business Day" means any day that is not a Saturday, Sunday or other day on
which  commercial  banks in The City of New York or in Los Angeles,  California,
are authorized by law to close.

     "Capital  Expenditures"  means,  for  any  period,  the  aggregate  of  all
expenditures  (whether paid in cash or accrued as liabilities and including that
portion of Capital Lease  Obligations  that is capitalized  on the  consolidated
balance  sheet of the  Borrower  and its  Subsidiaries)  by the Borrower and its
Subsidiaries  during  such period that are  included in the  property,  plant or
equipment  reflected in the  consolidated  balance sheet of the Borrower and its
Subsidiaries.

     "Capital  Lease  Obligations"  means,  with  respect  to  any  Person,  the
obligation  of such  Person to pay rent or other  amounts  under any lease  with
respect to any property (whether real,  personal or mixed) acquired or leased by
such Person that is required  by GAAP to be  accounted  for as a liability  on a
consolidated balance sheet of such Person.

     "Closing  Price" means the last  reported sale price regular way on the day
in  question  or, in case no such sale  takes  place on such day,  the  reported
closing bid price regular way of the Common Stock, in each case on the principal
national  securities exchange on which the Common Stock is listed or admitted to
trading,  or, if not listed or  admitted to trading on any  national  securities
exchange,  the  closing  bid price of the Common  Stock on the  Nasdaq  National
Market.  In the case of a closing  price of Common Stock on the Nasdaq  National
Market,  such price shall mean the closing  price  reported in the New York City
edition of The Wall Street Journal or, if not so reported, another authoritative
source.

     "Code"  means the Internal  Revenue  Code of 1986,  as amended from time to
time.

     "Common  Stock" means the common  stock,  par value $.01 per share,  of the
Company and any other stock of the Borrower  into which such common stock may be
converted or reclassified  (other than stock of the Borrower into which unissued
Common  Stock has been  reclassified)  or that may be issued in  respect  of, in
exchange  for, or in  substitution  of, such common stock by reason of any stock
splits,    stock    dividends,    distributions,     mergers,    consolidations,
recapitalizations or other like events.

     "Credit Documents" means,  collectively,  this Agreement; all of the Notes;
that certain Security Agreement, of even date herewith, between the Borrower, as
debtor,  and the  Lender,  as secured  party;  and any  documents  executed  and
delivered,  or filings  made,  pursuant to or in  connection  with such Security
Agreement,  including any financing  statements  filed by the Lender pursuant to
the Uniform  Commercial  Code and any filings made by the Lender with the Patent
and Trademark Office.

     "Current Assets" means, at any date of determination,  consolidated current
assets of the Borrower and its Subsidiaries.

     "Current  Liabilities"  means, at any date of  determination,  consolidated
current liabilities of the Borrower and its Subsidiaries, less the amount of the
current  portion of, and any accrued  interest on,  Indebtedness of the Borrower
and its Subsidiaries.

     "Default" means any event or circumstance  which, with the giving of notice
or the passage of time, or both, would be an Event of Default.

     "Disclosure  Package"  has the  meaning  assigned  to such term in  Section
5.01(h).

     "EBITDA" means,  for any period,  the sum of (i) consolidated net income of
the  Borrower  and  its  Subsidiaries  for  such  period,  adjusted  to  exclude
non-recurring  gains and losses on unusual  items and (ii)  consolidated  income
taxes,  interest  income,  Interest  Expense,   depreciation,  and  amortization
(including, without limitation,  amortization associated with goodwill, deferred
debt expenses, restricted stock and option costs and non-competition agreements)
of the Borrower and its Subsidiaries for such period.

     "Effective Time" has the meaning assigned to such term in Section 6.01.

     "Environmental  Claim"  means  any  claim,  assertion,  demand,  notice  of
violation,  suit,  administrative  or judicial  proceeding,  regulatory  action,
investigation,  information request or order involving any hazardous  substance,
Environmental  Law, noise or odor pollution or any injury or threat of injury to
human health, property or the environment.

     "Environmental  Law" means any federal,  state, local or foreign statute or
common law, regulation,  order, decree,  opinion or agency requirement as now in
effect or  hereinafter  adopted  relating to (i) the  handling,  use,  presence,
disposal  or  release  of  any  hazardous  substance  or  (ii)  the  protection,
preservation  or  restoration  of the  environment,  natural  resources or human
health or safety.

     "ERISA"  means the Employee  Retirement  Income  Security  Act of 1974,  as
amended from time to time.

     "ERISA  Group" means the Borrower and all members of a controlled  group of
corporations and all trades or businesses  (whether or not  incorporated)  under
common  control  which,  together  with the  Borrower,  are  treated as a single
employer  under  Section 414 of the Code or are  considered  to be one  employer
under Section 4001 of ERISA.

     "Event of Default" has the meaning assigned to such term in Section 8.01.

     "Excluded  Taxes"  means all present  and future  taxes,  levies,  imposts,
duties, deductions,  withholdings, fees, liabilities and similar charges imposed
on or measured by the overall net income of the Lender (or any office, branch or
Subsidiary of the Lender) or any  franchise  taxes,  taxes on doing  business or
taxes  measured  by capital or net worth  imposed on the Lender (or any  office,
branch or Subsidiary  of the Lender),  in each case imposed by the United States
of America or any political  subdivision or taxing authority thereof or therein,
or taxes on or  measured  by the  overall  net income of any  office,  branch or
Subsidiary  of the Lender or any taxes,  levies,  imposts,  duties,  deductions,
withholdings,  fees,  liabilities  and  similar  changes  imposed by any foreign
country or subdivision thereof.

     "Exercise  Price"  has the  meaning  assigned  to such term in the  Warrant
Agreement.

     "External   Scaleup  Costs"  means  the  costs  incurred  by  the  Borrower
associated  with the  development of the scale-up of raw  materials,  the active
pharmaceutical  ingredient  and final dose  formulation  necessary to permit the
Product  (as  defined  in  that  certain  Amended  and  Restated   Ophthalmology
Development  & License  Agreement  between the  Borrower and an affiliate of the
Lender) to be  manufactured  by an entity  other than the  Borrower.  Such costs
include,  but are not limited to, the costs of development  work performed,  raw
materials used in development and stability and equipment needed.

     "Federal Reserve Board" means the Board of Governors of the Federal Reserve
System (or any successor Governmental Authority).

     "GAAP" means generally accepted accounting principles,  as set forth in the
opinions and  pronouncements of the Accounting  Principles Board of the American
Institute of Certified Public  Accountants and statements and  pronouncements of
the Financial  Accounting  Standards  Board or in such other  statements by such
other  entities as may be approved by a  significant  segment of the  accounting
profession of the United States of America.

     "Governmental Authority" means any nation or government, any state or other
political subdivision thereof and any entity exercising executive,  legislative,
judicial, regulatory or administrative functions of or pertaining to government.

     "Guaranty" means, with respect to any Person, any obligation, contingent or
otherwise,  of such  Person  guaranteeing  or  having  the  economic  effect  of
guaranteeing any Indebtedness of any other Person (the "primary obligor") in any
manner,  whether  directly or  indirectly,  and including any obligation of such
Person,  (i) to purchase or pay (or advance or supply  funds for the purchase or
payment of) such  Indebtedness or to purchase (or to advance or supply funds for
the  purchase of) any  security  for the payment of such  Indebtedness,  (ii) to
purchase property, securities or services for the purpose of assuring the holder
of such  Indebtedness  of the payment of such  Indebtedness or (iii) to maintain
working capital,  equity capital or the financial  condition or liquidity of the
primary  obligor so as to enable the primary  obligor to pay such  Indebtedness.
The terms "Guaranteed",  "Guaranteeing" and "Guarantor" shall have corresponding
meanings.

     "Hazardous Substance" means any substance, in any concentration or mixture,
that is (i) listed,  classified or regulated  pursuant to any Environmental Law,
(ii)   petroleum   product  or   by-product,   asbestos   containing   material,
polychlorinated  biphenyls,  radioactive material or radon or (iii) any waste or
other substance  regulated by any  Governmental  Authority or any  Environmental
Law.

     "Indebtedness"  means,  with respect to any Person,  (i) all obligations of
such Person for borrowed money or for the deferred purchase price of property or
services (including all obligations,  contingent or otherwise, of such Person in
connection  with  letters  of  credit,   bankers'  acceptances,   Interest  Rate
Protection  Agreements or other similar  instruments,  including currency swaps)
other than indebtedness to trade creditors and service providers incurred in the
ordinary course of business and payable on usual and customary  terms,  (ii) all
obligations  of such  Person  evidenced  by bonds,  notes,  debentures  or other
similar  instruments,  (iii)  all  indebtedness  created  or  arising  under any
conditional  sale or other title  retention  agreement  with respect to property
acquired by such Person  (even  though the  remedies  available to the seller or
lender  under  such  agreement  are  limited  to  repossession  or  sale of such
property),   (iv)  all  Capital  Lease  Obligations  of  such  Person,  (v)  all
obligations  of the types  described in clauses (i),  (ii),  (iii) or (iv) above
secured  by (or for which the  obligee  has an  existing  right,  contingent  or
otherwise,  to be  secured  by)  any  Lien  upon or in any  property  (including
accounts, contract rights and other intangibles) owned by such Person (up to the
value of such  property),  even  though  such  Person has not  assumed or become
liable for the payment of such Indebtedness,  (vi) all preferred stock issued by
such  Person or any  Subsidiary  of such  Person,  valued at the  greater of its
voluntary  or  involuntary   liquidation  preference  plus  accrued  and  unpaid
dividends, (vii) all Indebtedness of others Guaranteed by such Person and (viii)
all Indebtedness of any partnership of which such Person is a general partner.

     "Indemnitee" has the meaning assigned to such term in Section 4.04(b).

     "Interest  Expense" means,  for any period,  consolidated  interest expense
(including  that  attributable  to Capital  Lease  Obligations)  whether paid or
accrued,  of the Borrower and its  Subsidiaries  with respect to all outstanding
Indebtedness of the Borrower and its  Subsidiaries,  including all  commissions,
discounts  and other fees and charges  owed with respect to letter of credit and
bankers'  acceptance  financing  and net costs under  Interest  Rate  Protection
Agreements.

     "Interest  Rate  Protection   Agreement"   means  any  interest  rate  swap
agreement,  interest rate cap agreement or similar hedging arrangement used by a
Person to fix or cap a floating rate of interest on Indebtedness to a negotiated
maximum rate or amount.

     "Investment"  by any Person means any direct or indirect  loan,  advance or
other  extension of credit or capital  contribution to (by means of transfers of
cash or other  property to others or payments  for  property or services for the
account or use of others,  or otherwise),  or purchase or acquisition of capital
stock, bonds, notes,  debentures or other securities or evidence of Indebtedness
or other obligations of or issued by any other Person.

     "Key Agreements" means, collectively, the License Agreement, effective July
1, 1989,  between the  University of Toledo,  the Medical  College of Ohio,  St.
Vincent  Medical  Center and the Borrower,  as amended prior to the date hereof,
and the  Development and  Distribution  Agreement,  dated May 28, 1996,  between
Iridex Corporation and the Borrower, as amended prior to the date hereof.

     "Lender" has the meaning assigned to such term in the Preamble.

     "Lien" means, with respect to any asset of a Person, (i) any mortgage, deed
of trust, lien, pledge,  encumbrance,  charge or security interest in or on such
asset,  (ii) the  interest  of a vendor or lessor  under  any  conditional  sale
agreement,  capital lease or title retention  agreement  relating to such asset,
and (iii) in the case of securities,  any purchase option, call or similar right
of any other Person with respect to such securities.

     "Loans" means, collectively, the Quarterly Loans and the Additional Loans.

     "Material  Adverse Effect" means any material and adverse effect on (i) the
consolidated  business,  properties,   condition  (financial  or  otherwise)  or
operations,  present or prospective, of the Borrower and its Subsidiaries,  (ii)
the ability of the Borrower  timely to perform any of its material  obligations,
or of the Lender to exercise any remedy,  under any Credit Document or (iii) the
legality, validity, binding nature or enforceability of any Credit Document.

     "Maturity  Date" means the fifth  anniversary of the Borrowing Date for the
first Loan made pursuant to this Agreement.

     "Maximum Quarterly Amount" means, (i) for the Quarter  comprising  January,
February  and  March,  1999,  $3,750,000,  and (ii) for any other  Quarter  (the
"Reference  Quarter"),  the sum of $3,750,000  plus either (A) if and only if no
Quarterly  Loan was made in the  Quarter  immediately  preceding  the  Reference
Quarter  or the  principal  amount of the  Quarterly  Loan  made in the  Quarter
immediately  preceding the Reference Quarter was less than $3,750,000,  then the
amount equal to the amount by which  $3,750,000  exceeds the principal amount of
the  Quarterly  Loan,  if any,  made in the Quarter  immediately  preceding  the
Reference  Quarter,  or (B) if and only if the principal amount of the Quarterly
Loan made in the Quarter  immediately  preceding the Reference Quarter was equal
to or greater than $3,750,000, then zero.

     "Multiemployer  Plan"  means a  multiemployer  plan as  defined  in Section
4001(a)(3) of ERISA to which any member of the ERISA Group is making or accruing
an obligation to make  contributions or has within the preceding five plan years
made or accrued contributions.

     "Net Available Asset Disposition Proceeds" means, with respect to any Asset
Disposition  by any  Person,  all cash or readily  marketable  cash  equivalents
received  (including  by  way of  sale  or  discounting  of a  note,  instalment
receivable or other receivable,  but excluding any other consideration  received
in the form of assumption by the acquiree of Indebtedness  or other  obligations
relating to such  properties  or assets or received in any other  noncash  form)
therefrom  by such  Person,  net of (i)  all  legal,  title  and  recording  tax
expenses,  commissions  and other fees and  expenses  incurred  and all federal,
state, provincial, foreign and local taxes required to be accrued as a liability
as a  consequence  of such Asset  Disposition,  (ii) all  payments  made by such
Person or its Subsidiaries on any  Indebtedness  which is secured by such assets
in accordance  with the terms of any Lien upon or with respect to such assets or
which must by the terms of such Lien, or in order to obtain a necessary  consent
to such Asset  Disposition  or by  applicable  law be repaid out of the proceeds
from such Asset Disposition, and (iii) all distributions and other payments made
to minority interest holders in Subsidiaries of such Person or joint ventures as
a result of such Asset Disposition.

     "Net Available  Securities  Offering  Proceeds" means,  with respect to any
offer or sale of securities by any Person,  all cash or readily  marketable cash
equivalents received therefrom by such Person, net of all underwriting discounts
and commissions,  SEC filing fees, legal fees and disbursements,  printing fees,
fees of national securities exchanges or the Nasdaq National Market and auditing
fees incurred by such Person in connection with such offer or sale.

     "New Site" has the meaning assigned to such term in Section 7.02(e)(ix).

     "Note"  means a  promissory  note of the  Borrower in the form set forth in
Exhibit B, executed and delivered in  accordance  with Section 2.02,  3.01(b) or
6.02(b) in order to evidence a Loan.

     "Operating  Income" of any Person means,  for any period,  the consolidated
operating  income  (or loss) of such  Person  for such  period  determined  on a
consolidated basis in accordance with generally accepted accounting  principles;
provided  that there shall be excluded  therefrom  (a)  noncash  expense  items,
including but not limited to depreciation,  amortization,  noncash  compensation
costs and reserves, (b) the operating income (or loss) of any Person acquired by
such Person or a Subsidiary of such Person in a pooling-of-interests transaction
for any period prior to the date of such  transaction,  (c) the operating income
(but not  operating  loss) of any  Subsidiary of such Person which is subject to
restrictions   which   prevent  the  payment  of  dividends  or  the  making  of
distributions  to  such  Person  to the  extent  of such  restrictions,  (d) the
operating income (or loss) of any Person that is not a Subsidiary of such Person
except to the extent of the amount of dividends or other distributions  actually
paid to such Person by such other Person during such period, (e) gains or losses
on  Asset   Dispositions  by  such  Person  or  its  Subsidiaries  and  (f)  all
extraordinary gains and extraordinary losses.

     "Ophthalmology  Expense"  means,  for any period,  the direct and  indirect
costs incurred by the Company  associated  with the field of  ophthalmology  for
research,  pharmaceutical,  device and manufacturing development and preclinical
and clinical costs,  including,  (but not limited to) general and administrative
costs,  internal  scale-up costs,  preclinical costs as required for NDA filing,
clinical and regulatory  costs,  drug and device  development and  manufacturing
costs and consultants, but excluding External Scaleup Costs.

     "PBGC" means the Pension  Benefit  Guaranty  Corporation  (or any successor
Governmental Authority).

     "Pension Plan" means a Plan that (i) is an employee  pension  benefit plan,
as defined in Section 3(3) of ERISA (other than a  Multiemployer  Plan) and (ii)
is subject to the  provisions  of Title IV of ERISA or is subject to the minimum
funding standards under Section 412 of the Code.

     "Permitted Liens" means, collectively,  the following: (i) Liens for taxes,
assessments or charges not yet due or that are being  contested in good faith by
appropriate  proceedings  and (unless the amount  thereof is not material to the
Borrower's  consolidated  financial  condition) for which adequate  reserves are
being  maintained (in accordance with GAAP);  (ii) deposits or pledges to secure
obligations  under workers'  compensation,  social  security or similar laws, or
under unemployment insurance; (iii) deposits or pledges to secure bids, tenders,
contracts (other than contracts constituting  Indebtedness),  leases,  statutory
obligations,  surety  and  appeal  bonds and other  obligations  of like  nature
arising  in  the  ordinary  course  of  business;  (iv)  mechanics',   workers',
materialmen's  or similar Liens arising in the ordinary  course of business with
respect to  obligations  which are not overdue for a period of more than 30 days
or which are being contested in good faith by appropriate proceedings; (v) Liens
securing  judgments in an amount and for a period not  constituting  an Event of
Default under Section 8.01(i);  (vi) minor imperfections of title on real estate
that do not interfere  materially  with the use of such property or render title
unmarketable;  (vii) any Lien upon or in any property  hereafter acquired by the
Borrower or a Subsidiary  of the  Borrower,  provided  that such Lien is created
contemporaneously  with such acquisition to secure or provide for the payment or
financing of any part of the cost (including  construction  costs) thereof,  and
provided,  further, that such Lien attaches only to the property so acquired and
fixed  improvements  thereon,  accessions  thereto,  replacements  and  proceeds
thereof, and substitutions  therefor;  (viii) Liens existing on the date hereof;
(ix) Liens on equipment leased by the Borrower or any Subsidiary of the Borrower
pursuant  to a  capital  lease in the  ordinary  course of  business  (including
replacements  and  proceeds  thereof,   substitutions  therefor  and  accessions
thereto)  incurred  solely  for the  purpose  of  financing  the  lease  of such
equipment;  (x) leases or subleases  granted to others in the ordinary course of
Borrower's or its Subsidiary's  business not interfering in any material respect
with the business of Borrower  and its  Subsidiaries  taken as a whole,  and any
interest or title of a lessor under any lease; (xi) Liens on assets that existed
at the time such assets were acquired by Borrower or any  Subsidiary  (including
Liens on assets of any corporation that existed at the time it became or becomes
a  Subsidiary  of the  Borrower);  provided  such  Liens  were  not  granted  in
contemplation of or in connection with the acquisition of such asset by Borrower
or any such Subsidiary;  (xii) Liens in favor of customs and revenue authorities
arising as a matter of law to secure  payments of customs  duties in  connection
with the importation of goods;  (xiii) Liens which constitute  rights of set-off
of a  customary  nature or  banker's  Liens with  respect to amounts on deposit,
whether  arising  by  operation  of  law  or by  contract,  in  connection  with
arrangement  entered into with banks in the ordinary  course of business;  (xiv)
Liens on insurance  proceeds in favor of insurance  companies  granted solely as
security  for  financed  premiums;  and  (xv) any Lien  renewing,  extending  or
refinancing  a Lien  permitted by the  foregoing,  provided  that the  principal
amount  secured is not increased and the Lien is not extended to other  property
(other than by a substitution of like property).

     "Person" means any  individual,  sole  proprietorship,  partnership,  joint
venture,   trust,   unincorporated   organization,   association,   corporation,
institution,  public benefit corporation, entity or government (whether Federal,
state,  county,  city,  municipal or otherwise,  including any  instrumentality,
division, agency, body or department thereof).

     "Plan"  means an employee  benefit plan as defined in Section 3(3) of ERISA
(other than a  Multiemployer  Plan) which is maintained or contributed to by the
Borrower or any member of the ERISA Group.

     "Quarter"  means each of the six calendar  quarters  consisting of January,
February and March, 1999; April, May and June, 1999; July, August and September,
1999; October,  November and December, 1999; January,  February and March, 2000;
and April, May and June, 2000.

     "Quarterly Loan" has the meaning assigned to such term in Section 2.01.

     "Related Person" of any Person means,  without  limitation,  any officer or
director of such Person or any other Person owning 5% or more of the outstanding
common  stock of such Person or 5% or more of the Voting  Stock of such  Person.
For purpose of this Agreement, the Lender and its Affiliates shall not be deemed
to be Related Persons of the Borrower or any of its Subsidiaries.

     "Repayment  Shares"  has  the  meaning  assigned  to such  term in  Section
2.03(b).

     "Responsible Officer" means the chief executive officer,  president,  chief
financial officer, chief accounting officer or treasurer of the Borrower.

     "Sale and Leaseback  Transaction"  of any Person means an arrangement  with
any lender or investor or to which such lender or investor is a party  providing
for the leasing by such Person of any property or asset of such Person which has
been or is being  sold or  transferred  by such  Person  after  the  acquisition
thereof or the completion of construction  or commencement of operation  thereof
to such lender or investor or to any person to whom funds have been or are to be
advanced by such lender or investor on the security of such property or asset.

     "SEC"  means the  Securities  and  Exchange  Commission  (or any  successor
Governmental Authority).

     "Share  Repayment  Amount" has the meaning assigned to such term in Section
2.03(b).

     "Shareholders'  Equity" means, as of any date of  determination,  the total
consolidated  shareholders'  equity  (determined  without  duplication)  of  the
Borrower and its Subsidiaries at such date.

     "Solvent"  means,  with  respect  to a  Person  and  a  specified  date  of
determination, that at such date:

     (a) the present fair saleable value of such Person's assets is in excess of
the total amount of such Person's probable liabilities on its existing debts and
obligations  (including  contingent  liabilities)  as they become  absolute  and
matured;

     (b) such Person is able to pay its debts as they become due; and

     (c) such Person does not have  unreasonably  small capital to carry on such
Person's  business as  theretofore  operated  and all  businesses  in which such
Person then is about to engage.

     "Subsidiary"  means, at any time and with respect to any Person,  any other
Person the shares of stock or other ownership interests of which having ordinary
voting power to elect a majority of the board of  directors or other  matters of
such Person are at the time  owned,  or the  management  or policies of which is
otherwise at the time  controlled,  directly or  indirectly  through one or more
intermediaries  (including  other  Subsidiaries)  or both, by such first Person.
Unless otherwise qualified or the context indicates clearly to the contrary, all
references to a "Subsidiary"  or  "Subsidiaries"  in this  Agreement  refer to a
Subsidiary or Subsidiaries of the Borrower.

     "Surplus" has the meaning assigned to such term in Section 7.02(p).

     "Taxes" has the meaning assigned to such term in Section 4.03.

     "Trading  Day"  means a day on  which  the  principal  national  securities
exchange  on which the shares of Common  Stock are listed or admitted to trading
is open for the  transaction  of business  or, if the shares of Common Stock are
not listed or admitted to trading on any national securities  exchange, a day on
which the Nasdaq National Market is open for the transaction of business.

     "Voting  Stock" of any Person  means  capital  stock of such  Person  which
ordinarily has voting power for the election of directors (or persons performing
similar functions) of such Person.

     "Warrant" has the meaning assigned to such term in the Warrant Agreement.

     "Warrant  Agreement"  means the Warrant  Agreement,  of even date herewith,
between the Borrower and the Lender.

     "Warrant  Certificate" has the meaning assigned to such term in the Warrant
Agreement.
     "Warrant  Number"  means,  with respect to any Quarterly  Loan, a number of
Warrants  equal to the product of (i) the  Borrowing  Amount for such  Quarterly
Loan, divided by (ii) 62.50.

     "Wholly  Owned  Subsidiary"  means,  at any time and  with  respect  to any
Person,  a  Subsidiary,  all the shares of stock of all classes of which  (other
than directors'  qualifying shares) or other ownership interests at the time are
owned  directly or  indirectly  by such Person  and/or one or more other  Wholly
Owned Subsidiaries of such Person.


                                   ARTICLE II

                               The Credit Facility

     Section II.1. Loans. Subject to the terms and conditions of this Agreement,
the Lender  agrees to make a single  term loan  (each,  a  "Quarterly  Loan") in
dollars to the Borrower not more than once in each Quarter in a principal amount
not to exceed the Maximum  Quarterly  Amount per Quarter.  Each  Quarterly  Loan
shall be made on the  applicable  Borrowing  Date only in a principal  amount of
$1,000,000  or an integral  multiple of  $250,000 in excess  thereof,  but in no
event greater than the Maximum Quarterly Amount for such Quarter.

     Section II.2. Borrowing Procedure. In order to borrow a Quarterly Loan, the
Borrower shall deliver a Borrowing  Request to the treasurer of Lender, no later
than 12:00 Noon, New York time, on the thirtieth  Business Day of the Quarter to
which the Loan  relates;  provided,  however,  that any  Borrowing  Request with
respect to a Quarterly Loan for the Quarter consisting of January,  February and
March, 1999 may be furnished to the Lender at any time no later than 12:00 Noon,
New York time, on the fifteenth  Business Day following the Effective Time. Each
Borrowing  Request shall be  accompanied  by a duly executed Note in the form of
Exhibit B, dated as of the Borrowing Date and evidencing a loan in the principal
amount set forth in the Borrowing Request (the "Borrowing  Amount",  which shall
be  $1,000,000 or an integral  multiple of $250,000 in excess  thereof but shall
not exceed the Maximum  Quarterly Amount for such Quarter),  and a duly executed
Warrant Certificate evidencing a number of Warrants equal to the Warrant Number.
Subject  to  satisfaction,  or waiver by the Lender in  writing,  of each of the
applicable  conditions  precedent  contained  in Article  VI, on the  applicable
Borrowing  Date the Lender shall make  available  to the Borrower the  Borrowing
Amount.

     Section II.3.  Repayment.  (a) The aggregate  outstanding  principal of the
Loans shall be repaid in full, together with any accrued interest as of the date
of repayment,  not later than the Maturity Date.  Except as permitted by Section
2.03(b),  such principal and interest shall be repaid in cash.  Repaid Loans may
not be reborrowed.

     (b) If and only if the Common  Stock  shall have been listed or admitted to
trading  on a national  securities  exchange  or quoted on the  Nasdaq  National
Market on each of the 180 calendar  days  preceding  and  including the Maturity
Date,  then on, but not  following,  the Maturity Date, the Borrower may, at its
option, repay all or a portion of the aggregate principal of the Loans, together
with any accrued  interest as of the Maturity  Date, by delivering to the office
of the Lender  theretofore  designated in writing to the Borrower not later than
12:00 Noon, New York time, on the Maturity  Date, (i) an unlegended  certificate
for the number of shares of Common Stock (the  "Repayment  Shares") equal to the
product,  rounded up to the  nearest  whole  number,  of (A) the  portion of the
aggregate  principal of the Loans to be repaid pursuant to this Section 2.03(b),
together with any accrued  interest  thereon as of the Maturity Date (the "Share
Repayment Amount"), divided by (B) the Average Price; (ii) an opinion of counsel
for the Borrower (which counsel shall be satisfactory to the Lender) in the form
of  Exhibit  C;  (iii)  evidence  satisfactory  to the  Lender  of the  previous
expiration or  termination  of any waiting  period (and any  extension  thereof)
applicable to the  acquisition  by the Lender of the Repayment  Shares under the
Hart-Scott-Rodino  Antitrust  Improvements  Act of  1976,  as  amended,  and the
previous  receipt of all  governmental  and  contractual  permits,  consents and
approvals   necessary  in  connection  with  such  acquisition;   (iv)  evidence
satisfactory to the Lender of Borrower's  compliance with Section  2.03(c);  and
(v) a certified or official bank check in same day funds equal to the difference
of (A) the aggregate  principal  amount of the Loans,  together with any accrued
interest as of the Maturity Date, minus (B) the Share Repayment Amount.

     (c) The Borrower shall pay all transfer, stamp and other similar taxes that
may be imposed in respect of the  issuance or delivery of the  Repayment  Shares
pursuant to Section  2.03(b) and any and all filing fees  incurred by the Lender
pursuant to Section 2.03(b)(iv).

     Section II.4. Prepayment.  The Borrower may prepay portions of the Loans by
giving  notice to the  treasurer  of the Lender,  by  telephone,  telecopy or in
writing,  not later than 12:00 Noon (if not in writing,  to be so confirmed  not
later than 2:00 P.M.), New York time, on the Business Day preceding the proposed
date of  prepayment.  Each such  prepayment  shall be in an aggregate  principal
amount of ***** or  integral  multiples  of ***** in excess  thereof  (or if the
aggregate  amount  of  outstanding  Loans is less than  *****,  then all of such
lesser amount), together with accrued interest on the principal being prepaid to
the date of prepayment;  provided,  however,  that in the case of any prepayment
pursuant to Section 7.02(n),  7.02(o) or 7.02(p), such prepayment shall be in an
aggregate principal amount equal to ***** of the Net Available Asset Disposition
Proceeds,  ***** of the Net Available  Securities  Offering Proceeds or ***** of
the amount of the Surplus,  as the case may be, in any such case  together  with
accrued interest on the principal being repaid to the date of prepayment,  up to
but not in excess of the aggregate principal amount of, and accrued interest on,
the outstanding Loans. Each partial prepayment shall be applied to the principal
amount of the Loan or Loans designated by the Lender in its sole discretion, and
the  Lender  will  provide  Borrower  with  reasonable  notice  concerning  such
designation. Prepaid Loans may not be reborrowed.

     *****Confidential Treatment Requested


                                   ARTICLE III

                                    Interest

     Section  III.1.  Interest on Loans.  (a) Each Loan shall bear interest from
the date made until the date repaid,  payable pursuant to Section 3.01(b),  at a
rate per annum  equal to the Base Rate in effect  from time to time,  which rate
shall change as and when said Base Rate shall change.

     (b)  Interest  on the Loans  shall be payable in arrears on the last day of
each calendar quarter of each year (each such day, a "Quarterly  Payment Date"),
commencing with the first such Quarterly  Payment Date after the Effective Date,
and on the date  such  Loan is repaid or  prepaid,  in the  manner  set forth in
Section  4.01 or, if and only if  permitted  below,  by the  delivery  of a Note
evidencing  an  additional  loan made  pursuant to this  Agreement  and having a
principal amount equal to the amount of such interest, as set forth below.

          (i) On or prior to the fifth  Business Day  following  each  Quarterly
     Payment  Date prior to January 1, 2001,  the  Borrower  shall  execute  and
     deliver to the  treasurer  of the Lender a Note having a  principal  amount
     equal  to  the  aggregate  amount  of  all  interest  on  Loans  (including
     Additional  Loans) payable on such Quarterly  Payment Date.  Each such Note
     shall evidence an additional loan made pursuant to this Agreement and shall
     bear  interest in the manner and at the rate set forth in Section  3.01(a),
     which  interest  shall be payable  in the manner set forth in this  Section
     3.01(b).

          (ii) All interest on Loans (including Additional Loans) payable on any
     Quarterly Payment Date subsequent to December 31, 2000 shall be paid in the
     manner set forth in Section  4.01;  provided that if and only if EBITDA for
     the calendar quarter ending on such Quarterly  Payment Date does not exceed
     the amount of such interest as is payable on such  Quarterly  Payment Date,
     then,  subject to Section  3.01(b)(iii),  on or prior to the fifth Business
     Day following such  Quarterly  Payment Date, the Borrower shall execute and
     deliver to the  treasurer  of the Lender a Note having a  principal  amount
     equal  to  the  aggregate  amount  of  all  interest  on  Loans  (including
     Additional  Loans) payable on such Quarterly  Payment Date.  Each such Note
     shall evidence an additional loan made pursuant to this Agreement and shall
     bear  interest in the manner and at the rate set forth in Section  3.01(a),
     which  interest  shall be payable  in the manner set forth in this  Section
     3.01(b).

          (iii) The  Borrower  shall not be entitled to pay interest on Loans in
     the manner set forth in Section  3.01(b)(ii) in respect of interest payable
     on any of the  four  Quarterly  Payment  Dates  immediately  following  the
     closing of a primary  offering  or sale of  securities  by the  Borrower in
     which the Net Available  Securities Offering Proceeds from such offering or
     sale equals or exceeds $5,000,000.

     (c) No Warrants shall be issuable in connection with any Additional Loan.

     Section III.2.  Interest on Overdue Amounts. All overdue amounts (including
principal,  interest and fees)  hereunder,  and,  during the  continuance of any
Event of  Default  that  shall have  occurred,  each Loan  shall bear  interest,
payable on demand,  at a rate per annum equal to the sum of (i) 10% and (ii) the
rate of interest  applicable to such Loan,  changing as and when such rate shall
change.

     Section  III.3.  Day Counts.  Interest on Loans shall be  calculated on the
basis of (a) a 365- or, if  applicable,  a 366-day year for the actual number of
days elapsed.

     Section III.4.  Maximum  Interest Rate. (a) Nothing in this Agreement shall
require  the  Borrower  to pay  interest at a rate  exceeding  the maximum  rate
permitted by applicable law.

     (b) If the amount of interest payable to the Lender on any interest payment
date in  respect  of the  immediately  preceding  interest  computation  period,
computed pursuant to this Article III, would exceed the maximum amount permitted
by applicable  law to be charged by the Lender,  the amount of interest  payable
for its account on such interest payment date shall  automatically be reduced to
such maximum permissible amount.

     (c) If the  amount of  interest  payable  to the  Lender in  respect of any
interest  computation  period is reduced  pursuant  to Section  3.04(b)  and the
amount of interest payable for its account in respect of any subsequent interest
computation  period would be less than the maximum amount permitted by law to be
charged by the Lender,  then the amount of  interest  payable in respect of such
subsequent interest computation period shall be automatically  increased to such
maximum permissible amount;  provided that at no time shall the aggregate amount
by which interest paid to the Lender has been increased pursuant to this Section
3.04(c)  exceed the  aggregate  amount by which  interest paid to the Lender has
theretofore been reduced pursuant to Section 3.04(b).


                                   ARTICLE IV

                            Disbursement and Payment

     Section  IV.1.  Method and Time of  Payments.  (a)  Except as  specifically
permitted  by Section  3.01(b),  and except in the case of payments  pursuant to
Sections 3.02, 4.02, 4.03, 4.04 or payments otherwise  specified as payable upon
demand, which payments shall be made forthwith upon written demand therefor, all
payments by the Borrower  hereunder shall be made without setoff or counterclaim
to the Lender in dollars and in immediately available funds at the office of the
Lender  theretofore  designated  in writing to the  Borrower not later than 2:00
p.m., New York time, on the later of the date when due or the fifth Business Day
following  the  Borrower's  receipt of an oral or written  confirmation  made in
response to the request contemplated by Section 4.01(c).

     (b) Whenever  any payment  from the Borrower  shall be due on a day that is
not a Business  Day, the date of payment  thereof  shall be extended to the next
succeeding Business Day. If the date for any payment of principal is extended by
operation  of law or  otherwise,  interest  thereon  shall be  payable  for such
extended time.

     (c)  Promptly  upon receipt of a request by the  Borrower  therefor  (which
request may be made by telephone to the treasurer or any assistant  treasurer of
Pharmacia & Upjohn,  Inc.) the Lender shall confirm the Lender's  calculation of
the amount of any payment due on a particular date.

     Section  IV.2.  Compensation  for  Losses.  If  the  Borrower  revokes  any
Borrowing Request,  then the Borrower shall reimburse the Lender,  promptly upon
demand therefor,  for all fees and costs actually incurred or paid by the Lender
to third  parties in respect of funds  obtained by the Lender for the purpose of
making or maintaining the related Loan, or any portion thereof.  If requested by
the  Borrower,  Lender shall  provide to the Borrower  reasonable  documentation
concerning such fees and costs.

     Section IV.3. Withholding.  All payments under this Agreement and under the
Notes  (including  payments of principal and  interest)  shall be payable to the
Lender free and clear of any and all present and future taxes, levies,  imposts,
duties,  deductions,  withholdings,  fees, liabilities and similar charges other
than Excluded  Taxes  (collectively,  "Taxes").  If any Taxes are required to be
withheld or deducted  from any amount  payable  under this  Agreement,  then the
amount  payable  under this  Agreement  shall be increased to the amount  which,
after deduction from such increased  amount of all Taxes required to be withheld
or deducted therefrom,  will yield to the Lender the amount stated to be payable
under  this  Agreement;  provided,  however,  that  amounts  payable  under this
Agreement shall not be increased in respect of any Taxes required to be withheld
or deducted  solely as a  consequence  of the Lender's  status as a  nonresident
alien,  as such term is defined in the Code.  The  Borrower  shall also hold the
Lender  harmless  and  indemnify it for any stamp or other taxes with respect to
the preparation,  execution, delivery, recording,  performance or enforcement of
the Credit Documents (all of which shall be included within "Taxes").  If any of
the Taxes  specified in this  Section 4.03 are paid by the Lender,  the Borrower
shall,  upon  demand of the  Lender,  promptly  reimburse  the  Lender  for such
payments,  together  with any  interest,  penalties  and  expenses  incurred  in
connection  therewith.  The Borrower shall deliver to the Lender certificates or
other valid  vouchers for all Taxes or other charges  deducted from or paid with
respect to payments made by the Borrower hereunder.

     Section  IV.4.  Expenses;  Indemnity.  (a) The  Borrower  agrees  to pay or
reimburse  the  Lender  for  all  reasonable  costs  and  expenses  incurred  in
connection  with the  enforcement  or  preservation  of any  rights  under  this
Agreement, any other Credit Documents, and any such other documents,  including,
without  limitation,  the reasonable  fees and  disbursements  of counsel to the
Lender (but  excluding fees and  disbursements  incurred on or prior to the date
hereof in negotiating and preparing the Credit  Documents);  provided,  however,
that in the  event  of any  litigation  between  the  Borrower  and  the  Lender
initiated prior to any Event of Default  specified in Section 8.01(g) or (h) and
arising  out of the  matters  set  forth  in  Section  4.04(b)(i),  the fees and
disbursements  of counsel to the Lender  shall be borne by the  Borrower  if and
only if the  Lender  is the  prevailing  party.  The  Borrower  also  agrees  to
indemnify the Lender against any transfer taxes,  documentary taxes, assessments
or charges made by any  Governmental  Authority by reason of the  execution  and
delivery of any Credit Document.

     (b) The  Borrower  agrees  to  indemnify  the  Lender  and  its  directors,
officers,  employees,  agents and  Affiliates  (for purposes of this  paragraph,
each, an "Indemnitee")  against,  and to hold each Indemnitee harmless from, any
and all claims,  liabilities,  damages,  losses,  costs,  charges  and  expenses
(including  fees and  expenses of counsel)  incurred by or asserted  against any
Indemnitee  arising out of, in any way connected with, or as a result of (i) the
execution  or delivery of any Credit  Document or any  agreement  or  instrument
contemplated by any Credit  Document,  the performance by the parties thereto of
their  respective  obligations  under any Credit  Document,  the  enforcement or
preservation by the parties thereto of their respective  rights under any Credit
Document or the  consummation  of the  transactions  contemplated  by any Credit
Document,  (ii)  the use of the  proceeds  of the  Loans  or  (iii)  any  claim,
litigation,  investigation  or  proceeding  relating  to any  of the  foregoing,
whether or not any Indemnitee is a party thereto. The provisions of this Section
4.04(b)  shall not operate or be construed to indemnify the Lender  against,  or
hold it harmless from, any claims, liabilities,  damages, losses, costs, charges
and expenses  (including  fees and expenses of counsel)  incurred by or asserted
against the Lender  arising out of or connected  with any  litigation  initiated
prior to any Event of Default specified in Section 8.01(g) or (h) solely between
the Borrower and the Lender in which the Lender is not the prevailing party.

     (c) All amounts due under this Section 4.04 shall be payable in immediately
available funds upon written demand therefor.

     Section IV.5.  Survival.  The provisions of Sections 4.02,  4.03,  4.04 and
this Section 4.05 shall remain operative and in full force and effect regardless
of the  expiration  of the  term  of this  Agreement,  the  consummation  of the
transactions  contemplated  hereby,  the  repayment  of any of  the  Loans,  the
invalidity or  unenforceability of any term or provision of any Credit Document,
or any investigation made by or on behalf of the Lender.

                                    ARTICLE V

                         Representations and Warranties

     Section V.1.  Representations  and Warranties.  The Borrower represents and
warrants to the Lender as follows:

     (a)  Subsidiaries.  At the date hereof,  the  Borrower has no  Subsidiaries
other than those Persons listed on Schedule 5.01(a).

     (b) Good Standing and Power. The Borrower and each of its Subsidiaries is a
corporation,  duly  incorporated and validly existing in good standing under the
laws of the jurisdiction of its  incorporation;  each has the corporate power to
own its property and to carry on its business as now being  conducted;  and each
is duly qualified to do business and is in good standing in each jurisdiction in
which the character of the properties  owned or leased by it therein or in which
the transaction of its business makes such qualification necessary, except where
the failure to be so qualified,  or to be in good standing,  individually  or in
the  aggregate,  could not  reasonably  be expected  to have a Material  Adverse
Effect.

     (c)  Corporate  Authority.  The  Borrower  has  full  corporate  power  and
authority  to execute and  deliver,  and to incur and  perform  its  obligations
under, each of the Credit  Documents,  all of which have been duly authorized by
all  proper  and  necessary   corporate   action.  No  consent  or  approval  of
stockholders  is required as a condition to the validity or  performance  of, or
the  exercise by the Lender of any of its rights or remedies  under,  any Credit
Document.

     (d) Authorizations. All authorizations, consents, approvals, registrations,
notices,  exemptions  and licenses  with or from any  Governmental  Authority or
other  Person  necessary  for the  execution,  delivery and  performance  by the
Borrower  of, and the  incurrence  and  performance  of each of its  obligations
under,  each of the  Credit  Documents,  and the  exercise  by the Lender of its
remedies  under each of the Credit  Documents have been effected or obtained and
are in full force and effect.

     (e) Binding  Obligation.  This  Agreement  constitutes  and, when issued in
accordance  with the  terms  hereof,  each Note  will  constitute  the valid and
legally  binding  obligation of the Borrower  enforceable in accordance with its
terms,  subject as to  enforcement to  bankruptcy,  insolvency,  reorganization,
moratorium  and similar laws of general  applicability  relating to or affecting
creditors' rights and to general equity principles.

     (f) Litigation.  There are no proceedings or investigations now pending or,
to the knowledge of the Borrower,  threatened  before any court or arbitrator or
before or by any Governmental Authority which, individually or in the aggregate,
could reasonably be expected to have a Material Adverse Effect.

     (g) No Conflicts. There is no statute, regulation, rule, order or judgment,
and no provision of any agreement or instrument binding upon the Borrower or any
of its  Subsidiaries,  or affecting  their  properties,  and no provision of the
certificate of incorporation or bylaws (or similar constitutive  instruments) of
the Borrower or any of its Subsidiaries,  that would prohibit,  conflict with or
in any way impair the execution or delivery of, or the incurrence or performance
of any obligations of the Borrower under, any Credit  Document,  or result in or
require the  creation or  imposition  of any Lien on property of the Borrower or
any  of  its  Subsidiaries  as a  consequence  of the  execution,  delivery  and
performance of any Credit Document.

     (h)  Financial  Condition.  Except  as  disclosed  in  filings  made by the
Borrower with the SEC prior to the date hereof or in the press  releases  issued
by the  Company  since  September  30,  1998 and  prior to the date  hereof  and
attached to that certain letter,  dated the date hereof,  from an officer of the
Borrower to an employee of the Lender  making  reference to this  Section  (such
filings and such press releases collectively, the "Disclosure Package"), (i) The
consolidated  balance  sheet of the Borrower as of December  31, 1997,  together
with consolidated statements of income,  shareholders' equity and cash flows for
the  fiscal  year  then  ended,  reported  upon by  Ernst & Young  LLP,  and the
unaudited  consolidated  balance sheet of the Borrower as of September 30, 1998,
together  with  consolidated  statements  of income  and cash flows for the nine
months then ended,  heretofore  delivered to the Lender,  present fairly, in all
material  respects,   the  Borrower's   consolidated   financial  condition  and
consolidated  results of operations as of the dates and for the periods referred
to  and  have  been  prepared  in  accordance  with  GAAP  consistently  applied
throughout the period involved. There are no material liabilities (whether known
or  unknown,  direct  or  indirect,  fixed  or  contingent,  and of  any  nature
whatsoever)  of the Borrower or any of its  Subsidiaries  as of the date of such
balance sheet that are not reflected therein or in the notes thereto.

          (ii) Except as disclosed in the Disclosure Package,  there has been no
     material adverse change in the business,  properties,  condition (financial
     or otherwise) or operations,  present or  prospective,  of the Borrower and
     its  Subsidiaries  since the date of the balance  sheet dated  December 31,
     1997  referred  to in  Section  5.01(h)(i).  Except  as  disclosed  in  the
     Disclosure  Package,  since  December 31,  1997,  there has not occurred or
     arisen any event,  condition or circumstance  that,  individually or in the
     aggregate, could reasonably be expected to have a Material Adverse Effect.

     (i) Taxes. Each of the Borrower and its Subsidiaries has filed or caused to
be filed all tax returns  that are  required to be filed and paid all taxes that
are  required  to be  shown  to be due and  payable  on said  returns  or on any
assessment  made  against  it or  any of  its  property  and  all  other  taxes,
assessments, fees, liabilities,  penalties or other charges imposed on it or any
of  its  property  by  any  Governmental   Authority,   except  for  any  taxes,
assessments,  fees,  liabilities,  penalties  or other  charges  which are being
contested  in good faith and (unless the amount  thereof is not  material to the
Borrower's  consolidated  financial  condition) for which adequate reserves have
been established in accordance with GAAP.

     (j) Use of Proceeds. The proceeds of the Loans will be used by the Borrower
for general corporate purposes.

     (k) Margin Regulations. The making of the Loans and the use of the proceeds
thereof  as  contemplated  by  the  Credit  Documents  will  not  violate  or be
inconsistent  with  any of  the  provisions  of  Regulation  U,  T or X (or  any
successor regulation or regulations) of the Federal Reserve Board.

     (l) Compliance with ERISA.  Each member of the ERISA Group is in compliance
with the applicable  provisions of ERISA and the Code with respect to each Plan,
except for any  failure so to comply  that,  individually  or in the  aggregate,
could not reasonably be expected to have a Material Adverse Effect. No member of
the ERISA Group has (i) an accumulated  funding  deficiency under Section 412 of
the Code in respect of any Pension Plan,  whether or not waived,  (ii) failed to
make any  contribution  or payment to any Pension Plan, or made any amendment to
any Pension Plan, which has resulted or could result in the imposition of a Lien
or the  posting of a bond or other  security  under  Section  302(f) of ERISA or
Section  401(a)(29) of the Code,  (iii) incurred any liability under Title IV of
ERISA other than a liability  to the PBGC for  premiums  under  Section  4007 of
ERISA, all of which have been paid or (iv) engaged in a transaction with respect
to a Plan,  which (assuming the taxable period of such  transaction,  within the
meaning  of  Section  4975(f)(2)  of the Code,  to have  expired  as of the date
hereof) has  resulted or could  reasonably  be expected to result in such member
being  subject to a material tax or penalty  imposed by Section 4975 of the Code
or Section 502 of ERISA.

     (m)  Not  an  Investment  Company.  Neither  the  Borrower  nor  any of its
Subsidiaries  is (i) an  "investment  company" or a company  "controlled"  by an
"investment  company" within the meaning of the Investment  Company Act of 1940,
as amended,  or (ii)  subject to  regulation  under the Public  Utility  Holding
Company Act of 1935,  the Federal  Power Act,  each as amended,  or any foreign,
federal,  state or local  statute or  regulation  limiting  its ability to incur
indebtedness for money borrowed as contemplated hereby.

     (n)  Properties.  Each of the  Borrower and its  Subsidiaries  has good and
marketable  title to, or valid  leasehold  interests  in, all of its  respective
properties and assets  (excluding  intellectual  property) that are reflected on
the consolidated balance sheet of the Borrower as of September 30, 1998 referred
to in Section 5.01(h),  except for such immaterial properties and assets as have
been disposed of in the ordinary course of business and except for minor defects
in title that do not  interfere  with the ability of the  Borrower or any of its
Subsidiaries  to conduct its business as now  conducted.  Except as set forth in
the Disclosure Package, the Borrower and its Subsidiaries own or are licensed to
use or  otherwise  have the  right to use (or could  obtain  such  ownership  or
licences  or rights on terms not  materially  adverse  to the  Borrower  and its
Subsidiaries, taken as a whole) all of the intellectual property rights that are
reasonably necessary for the operation of their respective businesses.  All such
assets and properties  are so owned or held free and clear of all Liens,  except
Permitted Encumbrances.

     (o) Compliance with Laws and Charter Documents.

     (i) As a result of the Borrower's  performing any of its obligations  under
the Credit  Documents,  neither the Borrower nor any of its Subsidiaries will be
in  violation  of (a)  any  law,  statute,  rule,  regulation  or  order  of any
Governmental  Authority  (including  Environmental Laws) applicable to it or its
properties or assets or (b) its certificate of incorporation or bylaws.

     (ii) Neither the Borrower  nor any of its  Subsidiaries  is in violation of
(A) any law, statute,  rule,  regulation or order of any Governmental  Authority
(including  Environmental  Laws) applicable to it or its properties,  except for
any violations  which could not reasonably be expected,  individually  or in the
aggregate,  to  have a  Material  Adverse  Effect,  or (B)  its  certificate  of
incorporation or bylaws.

     (iii) Each of the Borrower  and its  Subsidiaries  has all  authorizations,
consents, approvals,  registrations,  franchises,  licenses and permits, with or
from  Governmental  Authorities and other Persons as are necessary for it to own
its  properties  and conduct its  business as now  conducted  and the absence of
which could reasonably be expected,  individually or in the aggregate, to have a
Material Adverse Effect.

     (p)  Environmental  Protection.  To the  Borrower's  knowledge,  based upon
reasonable  investigation,  all real property owned or leased by the Borrower or
any of its Subsidiaries is free of  contamination  from any substance that could
result in the  incurrence  of  material  liabilities,  or  constituent  thereof,
currently   identified  or  listed  as  hazardous  or  toxic   pursuant  to  the
Comprehensive Environmental Response,  Compensation and Liability Act, 42 U.S.C.
9601, et seq., or any other Environmental Laws, or any other substance which has
in the past or could at any time in the  future  cause or  constitute  a health,
safety or environmental hazard to any person or property,  including asbestos in
any building, petroleum products, PCBs, pesticides, or radioactive materials. To
the  Borrower's  knowledge,  based upon  reasonable  investigation,  neither the
Borrower nor any of its Subsidiaries has caused or suffered to occur any release
of any Hazardous  Substance into the environment or any other  conditions  that,
individually or in the aggregate,  could reasonably be expected to result in the
incurrence  of  material   liabilities   or  any  material   violations  of  any
Environmental  Laws.  To  the  Borrower's   knowledge,   based  upon  reasonable
investigation,  neither the Borrower nor any of its  Subsidiaries  has caused or
suffered to occur any condition on any of their property that could give rise to
the imposition of any lien under the Environmental  Laws. Except as disclosed in
the  Disclosure  Package,  to the  Borrower's  knowledge,  based  on  reasonable
investigation,  neither  the  Borrower  nor any  Subsidiary  is  engaged  in any
manufacturing or any other operations,  other than the use of petroleum products
for  vehicles,  that  require  the use,  handling,  transportation,  storage  or
disposal of any Hazardous  Substance,  where such operations  require permits or
are otherwise regulated pursuant to the Environmental Laws.

     (q)  Insurance.  All of the  properties  and operations of the Borrower and
each  of its  Subsidiaries  of a  character  usually  insured  by  companies  of
established  reputation  engaged  in the same or a  similar  business  similarly
situated are adequately  insured,  by financially sound and reputable  insurers,
against loss or damage of the kinds and in amounts  customarily  insured against
by such Persons,  and the Borrower and each of its Subsidiaries carry, with such
insurers in customary  amounts,  such other  insurance as is usually  carried by
companies of established  reputation  engaged in the same or a similar  business
similarly situated.

     (r) Adverse  Contracts.  Except as  disclosed  in the  Disclosure  Package,
neither the Borrower nor any of its Subsidiaries is a party to, nor is it or any
of its  property  subject  to or bound by, any  agreement  or  instrument  which
restricts its ability to conduct its business,  or could reasonably be expected,
individually or in the aggregate, to have a Material Adverse Effect.

     (s)  Solvency.  The Borrower  and each of its  Subsidiaries  is and,  after
giving effect to Loans and the other transactions contemplated hereby, and after
payment of all estimated legal,  investment  banking,  accounting and other fees
related  thereto,  the  Borrower and each of its  Subsidiaries  will be Solvent.
Neither the Borrower nor any of its  Subsidiaries is and, after giving effect to
Loans and the other transactions  contemplated  hereby, and after payment of all
estimated legal, investment banking,  accounting and other fees related thereto,
the Borrower and each of its  Subsidiaries  will not be insolvent (as defined in
any of Uniform  Laws  Annotated,  Uniform  Fraudulent  Transfer  Act ss. 2 (West
1985);  Cal. Civ. Code ss.  3439.02 (West 1997);  and Del. Code Ann. tit. 6, ss.
1302 (1997)).

     (t)  Disclosure.   All   information   relating  to  the  Borrower  or  its
Subsidiaries  delivered  in  writing  to  the  Lender  in  connection  with  the
negotiation,  execution  and  delivery of this  Agreement  and the other  Credit
Documents,  taken  together  with the  information  set forth in the  Disclosure
Package,  is true and  complete in all material  respects.  There is no material
fact of which the Borrower is aware  which,  individually  or in the  aggregate,
would reasonably be expected adversely to influence the Lender's credit analysis
relating to the Borrower and its  Subsidiaries  which has not been  disclosed to
the Disclosure Package.

     Section  V.2  Survival.  All  representations  and  warranties  made by the
Borrower  in  this  Agreement,  and in the  certificates  or  other  instruments
prepared or delivered in connection  with or pursuant to this  Agreement,  shall
(i) be  considered  to have been  relied upon by the  Lender,  (ii)  survive the
making of Loans  regardless of any  investigation  made by, or on behalf of, the
Lender,  and (iii)  continue  in full force and  effect so long as any Loan,  or
other amount payable under any Credit Document remains unpaid.


                                   ARTICLE VI

                              Conditions Precedent

     Section  VI.1.  Conditions  to  the  Availability  of the  Commitment.  The
obligations of the Lender hereunder are subject to, and no Quarterly Loans shall
be made until the earliest time (the "Effective  Time") (which shall be no later
than the close of  business  in The City of New York on the fifth  Business  Day
following the Closing contemplated by that certain Equity Investment  Agreement,
dated as of January 15, 1999,  among the Borrower and certain  Affiliates of the
Lender)  on which each of the  following  conditions  precedent  shall have been
either satisfied or waived in writing by the Lender:

     (a) This  Agreement.  The  Agreement  shall  have  been duly  executed  and
delivered  by each of the Lender and the  Borrower  and each of the other Credit
Documents  shall have been duly  executed  and  delivered by each of the parties
thereto.

     (b)  Evidence of  Corporate  Action.  The Lender  shall have  received  the
following:

     (i) a copy of the  Certificate  of  Incorporation,  of the Borrower,  as in
effect on the Effective  Date,  certified by the Secretary of State of the State
of  Delaware,  and a  certificate  from such  Secretary  of State as to the good
standing  of the  Borrower,  in each case as of a date  reasonably  close to the
Effective Date; and

     (ii) a  certificate  of the  Secretary  or an  Assistant  Secretary  of the
Borrower,  dated the Effective Date, and stating (A) that attached  thereto is a
true and  complete  copy of the bylaws of the Borrower as in effect on such date
and at all  times  since the date of the  resolutions  described  in clause  (B)
below, (B) that attached thereto is a true and complete copy of resolutions duly
adopted by the Board of  Directors of the Borrower  authorizing  the  execution,
delivery and performance of this Agreement,  and that such  resolutions have not
been modified,  rescinded or amended and are in full force and effect,  (C) that
the certificate of  incorporation of the Borrower has not been amended since the
date of the last  amendment  thereto shown on the  certificate  of good standing
furnished  pursuant  to  clause  (i)  above,  and (D) as to the  incumbency  and
signature of each officer executing this Agreement or any document  delivered in
connection herewith on behalf of the Borrower.

     (c) Opinions of Counsel. The Lender shall have received a favorable written
opinion,  dated the  Effective  Date,  of Nida &  Maloney  PC,  counsel  for the
Borrower, in substantially the form of Exhibit D.

     (d)  Representations  and Warranties.  The  representations  and warranties
contained in Section 5.01 shall be true and correct on the Effective  Date,  and
the Lender shall have received a certificate, signed by a Responsible Officer of
the Borrower, to that effect.

     (e)  Other   Documents.   The  Lender  shall  have   received   such  other
certificates, opinions and other documents as the Lender reasonably may require.

     Section VI.2.  Conditions to All Quarterly  Loans.  The obligations of each
Lender to make each Quarterly Loan are subject to the conditions precedent that,
on the date of each Quarterly Loan and after giving effect thereto,  each of the
following conditions  precedent shall have been satisfied,  or waived in writing
by the Lender:

     (a) Borrowing  Request.  The Lender shall have received a Borrowing Request
in accordance with the terms of this Agreement.

     (b) Note.  The Lender shall have  received a duly executed Note in the form
of Exhibit B, dated as of the Borrowing  Date and evidencing a Quarterly Loan in
an aggregate principal equal to the Borrowing Amount.

     (c) Warrant Certificate.  The Borrower shall have duly issued to the Lender
a number  of  Warrants  equal to the  Warrant  Number  in  connection  with such
Quarterly  Loan and shall  have duly  executed  and  delivered  to the  Lender a
Warrant Certificate evidencing such Warrants.

     (d) No Default.  No Default or Event of Default  shall have occurred and be
continuing,  nor shall any Default or Event of Default  occur as a result of the
making of such Quarterly Loan.

     (e)  Representations  and Warranties;  Covenants.  The  representations and
warranties  contained in Section 5.01 shall have been true and correct when made
and (except to the extent  that any  representation  or warranty  speaks as of a
date  certain)  shall be true and  correct on the  Borrowing  Date with the same
effect as though such representations and warranties were made on such Borrowing
Date;  and the  Borrower  shall  have  complied  with all of its  covenants  and
agreements under the Credit Documents.

     Section  VI.3.  Satisfaction  of  Conditions  Precedent.  Each  of (i)  the
delivery by the Borrower of a Borrowing  Request  (unless the Borrower  notifies
the Lender in writing to the contrary prior to the Borrowing  Date) and (ii) the
acceptance  of the proceeds of a Quarterly  Loan shall be deemed to constitute a
certification  by the  Borrower  that,  as of the  Borrowing  Date,  each of the
conditions  precedent  contained in Sections  6.02(d) and (e) has been satisfied
with respect to any Loans then being made.


                                   ARTICLE VII

                                    Covenants

     Section VII.1. Affirmative Covenants. Until satisfaction in full of all the
obligations of the Borrower under the Credit Documents, the Borrower will:

     (a) Financial Statements; Compliance Certificates. Furnish to the Lender:

     (i) as soon as available,  but in no event more than 60 days  following the
end of each of the first  three  quarters  of each  fiscal  year,  copies of the
Borrower's  Quarterly  Report on Form 10-Q being filed with the SEC, which shall
include a consolidated  balance sheet and  consolidated  income statement of the
Borrower and its Subsidiaries for such quarter;


     (ii) as soon as available, but in no event more than 100 days following the
end of each fiscal year,  a copy of the  Borrower's  Annual  Report on Form 10-K
being  filed  with the SEC,  which  shall  include  the  consolidated  financial
statements of the Borrower and its Subsidiaries,  together with a report thereon
by  Ernst  &  Young  LLP  (or  another  firm  of  independent  certified  public
accountants reasonably satisfactory to the Lender), for such year;

     (iii) together with each report delivered  pursuant to Sections  7.01(a)(i)
and (ii), a certificate  of the Borrower,  signed by a Responsible  Officer,  in
substantially the form of Exhibit E, stating whether, as of the last date of the
financial  statements  included  in such  report,  any  event  has  occurred  or
circumstance  existed which,  individually  or in the  aggregate,  constituted a
Default or Event of  Default  (and,  if so,  detailing  the facts  with  respect
thereto) and whether the Borrower was in compliance with the covenants set forth
in this Article VII,  together with  calculations  to establish  the  Borrower's
compliance with the covenants contained in Section 7.03;

     (iv)  promptly upon the filing by the Borrower with the SEC or any national
securities  exchange or national quotation system of any registration  statement
(other  than a  registration  statement  on Form S-8 or an  equivalent  form) or
regular  periodic  report  (other  than  the  reports  referred  to in  Sections
7.01(a)(i) and (ii)),  notification  of such filing;  and, at the request of any
Lender,  the  Borrower  shall  deliver  to such  Lender  a copy  of such  filing
(excluding exhibits);

     (v) promptly upon the mailing  thereof to the  shareholders of the Borrower
generally  copies of all financial  statements,  reports and proxy statements so
mailed;

     (vi) within five Business Days of any  Responsible  Officer of the Borrower
obtaining  knowledge of any Default or Event of Default of any type specified in
Section  8.01(a),  (b),  (d),  (f), (g), (h) or (l), if such Default or Event of
Default  is then  continuing,  a  certificate  of a  Responsible  Officer of the
Borrower  stating  that such  certificate  is a "Notice of Default"  and setting
forth  the  details  thereof  and the  action  which the  Borrower  is taking or
proposes to take with respect thereto;

     (vii) within ten Business Days of any  Responsible  Officer of the Borrower
obtaining  knowledge of any Default or Event of Default of any type specified in
Section  8.01(c),(e),  (i),  (j) or (k), if such  Default or Event of Default is
then continuing,  a certificate of a Responsible Officer of the Borrower stating
that such  certificate  is a "Notice of Default"  and setting  forth the details
thereof  and the action  which the  Borrower  is taking or proposes to take with
respect thereto; and

     (viii) such additional  information,  reports or statements,  regarding the
business,  financial  condition or results of operations of the Borrower and its
Subsidiaries, as the Lender from time to time may reasonably request.

     (b) Corporate Existence.  Except as permitted by Section 7.02(a), maintain,
and cause each Subsidiary to maintain,  its corporate existence in good standing
and qualify and remain  qualified to do business in each  jurisdiction  in which
the  character of the  properties  owned or leased by it therein or in which the
transaction of its business is such that the failure to qualify, individually or
in the  aggregate,  could  reasonably  be  expected  to have a Material  Adverse
Effect.

     (c)  Conduct  of  Business.   Engage  in  as  its  principal  business  the
development  of  photoselective  drugs and light  producing  and light  delivery
medical devices and related or ancillary  businesses,  including but not limited
to the businesses of the Borrower described in the Disclosure Package; preserve,
renew and keep in full force and effect,  and cause each of its  Subsidiaries to
preserve,  renew and keep in full force and effect,  all franchises and licenses
necessary  or  desirable  in the  normal  conduct  of its and its  Subsidiaries'
business  and  the  loss  of  which,  individually  or in the  aggregate,  could
reasonably be expected to have a Material Adverse Effect;  and comply, and cause
each of its Subsidiaries to comply, with all applicable laws, orders,  rules and
regulations of all Governmental Authorities the failure with which so to comply,
individually  or in the  aggregate,  could  reasonably  be  expected  to  have a
Material Adverse Effect.

     (d)  Authorizations.  Obtain,  make and keep in full  force and  effect all
authorizations from and registrations with Governmental Authorities required for
the validity or enforceability of the Credit Documents.

     (e) Taxes. Pay and discharge, and cause each of its Subsidiaries to pay and
discharge,  all taxes,  assessments and governmental charges upon it, its income
and its properties  prior to the date on which  penalties are attached  thereto,
except to the extent that (i) such taxes,  assessments and governmental  charges
shall be contested in good faith and by appropriate  proceedings by the Borrower
or such  Subsidiary,  as the case may be, (ii) unless the amount  thereof is not
material to the Borrower's  consolidated financial condition,  adequate reserves
are maintained (in accordance with GAAP) by the Borrower or such Subsidiary,  as
the  case may be,  with  respect  thereto,  and  (iii)  any  failure  to pay and
discharge such taxes,  assessments and governmental charges could not reasonably
be  expected,  individually  or in the  aggregate,  to have a  Material  Adverse
Effect.
     (f) Insurance.  Maintain,  and cause each of its  Subsidiaries to maintain,
insurance with reputable  insurance  companies against such risks, of such types
(including  general  liability),  on such  properties  and in such amounts as is
customarily  maintained by similar businesses similarly situated, and provide to
the Lender a certificate or  certificates  of insurance  showing that the Lender
has been named as loss payee by endorsement to the policies for such insurance.

     (g) Inspection.  Permit, and cause each of its Subsidiaries to permit, upon
no fewer  than five  Business  Days'  notice,  the Lender to have one or more of
their officers and employees,  or any other Person  designated by the Lender, to
visit and inspect any of the properties of the Borrower and such  Subsidiary and
to examine the minute books,  books of account and other corporate and financial
records of the Borrower and such Subsidiary,  and discuss its affairs,  finances
and accounts with its officers and with the Borrower's independent  accountants,
during normal business hours and at such other reasonable times, for the purpose
of monitoring the Borrower's compliance with its obligations under agreements to
which the Lender is a party and for no other purpose.

     (h) Maintenance of Records.  For the Borrower and each of its  Subsidiaries
(i) keep  proper  books of record and  account in which  entries  sufficient  to
provide  financial  statements  in  accordance  with  GAAP  will  be made of all
dealings or transactions of or in relation to its business and affairs; (ii) set
up on its books  reserves  with  respect  to all  taxes,  assessments,  charges,
reviews and claims;  and (iii) on a current basis, set up on its books, from its
earnings,  appropriate reserves against doubtful accounts  receivable,  advances
and  investments  and  all  other  proper  reserves   (including  by  reason  of
enumeration,  reserves for  premiums,  if any, due on required  prepayments  and
reserves for depreciation,  obsolescence, or amortization of properties),  which
should be set aside from such  earnings in connection  with its  business.  (All
determinations  pursuant to this  Section  7.01(h)  shall be made in  accordance
with, or as required by, GAAP.)

     (i) Maintenance of Property.  Maintain, keep and preserve and cause each of
its  Subsidiaries  to maintain,  keep and preserve all of its properties in good
repair, working order and condition and from time to time make all necessary and
proper repairs, renewals,  replacements, and improvements thereto, except to the
extent that any  failure so to  maintain,  keep and  preserve  such  properties,
individually  or in the  aggregate,  could not  reasonably be expected to have a
Material Adverse Effect.

     (j) ERISA. Furnish to the Lender:

     (i) within ten days after a Responsible Officer learns that any "reportable
event" (as defined in Section 4043(c) of ERISA),  other than a reportable  event
for  which the  30-day  notice  requirement  has been  waived  by the PBGC,  has
occurred with respect to a Pension Plan, a statement setting forth details as to
such reportable event and the action proposed to be taken with respect thereto;

     (ii) within ten days after receipt  thereof,  a copy of any notice that any
member of the ERISA Group may receive from the PBGC relating to the intention of
the PBGC to terminate any Pension Plan or to appoint a trustee to administer any
Plan;

     (iii) within ten days after filing with any affected party (as such term is
defined in Section  4001 of ERISA) of a notice of intent to  terminate a Pension
Plan,  a copy of such notice and a statement  setting  forth the details of such
termination,  including  the amount of  liability,  if any, of any member of the
ERISA Group under Title IV of ERISA;

     (iv)  within  ten days after the  adoption  of a  material  amendment  to a
Pension Plan if, after giving  effect to such  amendment,  the Pension Plan is a
plan  described  in Section  4021(b) of ERISA,  a  statement  setting  forth the
details thereof;

     (v) within 30 days after  withdrawal from a Pension Plan during a plan year
for which any member of the ERISA  Group  could be subject  to  liability  under
Section 4063 or 4064 of ERISA,  a statement  setting forth the details  thereof,
including the amount of such liability;

     (vi)  within 30 days after  cessation  of  operations  by any member of the
ERISA Group at a facility under the  circumstances  described in Section 4062(e)
of ERISA, a statement setting forth the details thereof, including the amount of
liability  of the  Borrower  or a member of the ERISA  Group  under  Title IV of
ERISA;

     (vii)  within ten days after  adoption of an  amendment  to a Pension  Plan
which would require security to be given to the Pension Plan pursuant to Section
401(a)(29)  of the Code or Section 307 of ERISA,  a statement  setting forth the
details thereof, including the amount of such security;

     (viii)  within ten days after  failure by any member of the ERISA  Group to
make  payment to a Pension  Plan which would give rise to a lien in favor of the
Plan under  Section  302(f) of ERISA,  a  statement  setting  forth the  details
thereof, including the amount of such lien;

     (ix) within ten days after the due date for filing with the PBGC,  pursuant
to  Section  412(n)  of the  Code,  of a notice of  failure  to make a  required
installment or other payment with respect to a Pension Plan, a statement setting
forth  details  as to such  failure  and the  action  proposed  to be taken with
respect thereto; and

     (x) within 30 days after  receipt  thereof by any member of the ERISA Group
from the sponsor of a Multiemployer  Plan, a copy of each notice  concerning the
imposition of withdrawal  liability or the  termination or  reorganization  of a
Multiemployer Plan.

     (k) Notice of Defaults and Adverse Developments. Promptly notify the Lender
upon the  discovery  by any  Responsible  Officer of the  occurrence  of (i) any
Default or Event of Default; (ii) any event, development or circumstance whereby
the financial  statements most recently  furnished to the Lender fail to present
fairly,  in all material  respects,  and in accordance  with GAAP, the financial
condition and operating  results of the Borrower and its  Subsidiaries as of the
date of such financial statements;  (iii) any material litigation or proceedings
that are instituted or threatened (to the knowledge of the Borrower) against the
Borrower or any of its Subsidiaries or any of their respective assets;  (iv) any
event,  development or  circumstance  which,  individually  or in the aggregate,
could  reasonably  be  expected to result in an event or default  (or,  with the
giving  of  notice  or lapse of time or both,  an event of  default)  under  any
Indebtedness  and  the  amount  hereof;  and (v) any  other  development  in the
business  or affairs of the  Borrower or any of its  Subsidiaries  if the effect
thereof would reasonably be expected,  individually or in the aggregate, to have
a Material  Adverse  Effect;  in each case describing the nature thereof and the
action the Borrower proposes to take with respect thereto.

     (l) Environmental  Matters.  (i) Comply, and cause each of its Subsidiaries
to comply, in all material respects with all applicable Environmental Laws, (ii)
notify the Lender promptly after becoming aware of any  Environmental  Claim, or
any fact or circumstance that is reasonably likely to result in an Environmental
Claim or a material  violation  of any  Environmental  Law,  with respect to the
Borrower's  or any of its  Subsidiaries'  properties  or  facilities,  and (iii)
promptly  forward to the Lender a copy of any material  order,  notice,  permit,
application,  or any other  communication  or report received in connection with
any such matters as they may affect such premises.

     Section VII.2.  Negative  Covenants.  Until satisfaction in full of all the
obligations of the Borrower under the Credit Documents, the Borrower will not:

     (a)  Mergers,  Consolidations  and Sales of Assets.  Enter into any merger,
consolidation or share exchange, or acquire assets of any Person, or sell, lease
or otherwise  dispose of any of its assets, or permit any of its Subsidiaries so
to do, except that (i) any such  Subsidiary may merge or consolidate (A) with or
into  the  Borrower,  if the  Borrower  shall  be the  continuing  or  surviving
corporation,  or (B) with or into any one or more Wholly Owned Subsidiary of the
Borrower,(ii)  the Borrower or any Subsidiary of the Borrower may make any Asset
Disposition to the extent permitted by Section 7.02(n) and (iii) the Borrower or
any Subsidiary of the Borrower may acquire assets for cash consideration  which,
together  with  all  other  cash  consideration  paid  by  the  Borrower  or any
Subsidiary  for  assets on or  following  the date of this  Agreement,  does not
exceed  *****,  and may acquire  assets in exchange  for shares of Common  Stock
having a market value at the time of issuance  which,  together  with the market
value at time of  issuance  of all other  shares of Common  Stock  issued by the
Borrower in consideration for or in connection with the acquisition of assets on
or following the date of this  Agreement,  does not exceed *****;  provided that
the amount of Indebtedness assumed or incurred by the Borrower or any Subsidiary
of the Borrower in connection with the acquisition of assets on or following the
date of this  Agreement  pursuant to this  Section  7.02(a)(iii)  may not exceed
****** of the sum of the cash  consideration  paid, and the market value at time
of issuance of Common Stock issued,  in consideration  therefor or in connection
therewith.

     *****Confidential Treatment Requested

     (b) Liens.  Create,  incur,  assume or suffer to exist any Lien, other than
Permitted Liens, upon or in any of its or any of its  Subsidiaries'  property or
assets, whether now owned or hereafter acquired.

     (c)   Indebtedness.   Create,   incur,   assume  or  suffer  to  exist  any
Indebtedness, or permit any of its Subsidiaries so to do, except:

     (i) Indebtedness to the Lender under the Credit Documents,

     (ii)  Indebtedness  of the Borrower or any of its  Subsidiaries  secured by
Liens specifically permitted by Section 7.02(b),

     (iii) Guaranties to the extent permitted by Section 7.02(d),

     (iv) Indebtedness existing on the date hereof,

     (v)  Indebtedness  of Borrower to any Subsidiary,  and  Indebtedness of any
Subsidiary to Borrower or any other Subsidiary, and

     (vi) Extension, refinancings, modifications, amendments and restatements of
any of items of Permitted  Indebtedness (i) through (v) above, provided that the
principal amount thereof is not increased.

     (d) Contingent Liabilities.  Assume, Guaranty, endorse,  contingently agree
to purchase or otherwise  become liable upon the obligation of any other Person,
or permit any of its Subsidiaries to do so, except:

     (i) in  connection  with a merger or  consolidation  permitted  by  Section
7.02(a),

     (ii) by the endorsement of negotiable instruments for deposit or collection
or similar transactions in the ordinary course of business,

     (iii) Guaranties by the Borrower of contractual obligations (other than for
the payment of Indebtedness) of any of its Wholly Owned Subsidiaries, and

     (iv) Guaranties existing on the date hereof, but not extensions thereof.

     (e)  Loans  and  Investments.  Make any  Investment  or  permit  any of its
Subsidiaries to do so, except:

     (i) Investments existing on the date hereof,

     (ii) Investments consisting of the endorsement of negotiable instrument for
deposit or collection or similar transaction in the ordinary course of business,

     (iii) Investments accepted in connection with asset dispositions  permitted
by Section 7.02(n),

     (iv)  Investments of the Borrower in or to  Subsidiaries of the Borrower or
of Subsidiaries  of the Borrower in or to other  Subsidiaries of the Borrower or
in or to the Borrower,

     (v) Investments  consisting of travel advances,  employee  relocation loans
and other employee loans and advances in the ordinary course of business,

     (vi) Investments consisting of loans to employees, officers or directors of
the Borrower or its  Subsidiaries  outstanding on the date of this Agreement and
not exceeding an aggregate principal balance of *****,  relating to the purchase
or equity  securities of the Borrower or its  Subsidiaries  pursuant to employee
stock purchase plans approved by the Borrower's Board of Directors,

     *****Confidential Treatment Requested

     (vii) Investments  consisting of loans to employees,  officers or directors
of the Borrower and its  Subsidiaries  made on or subsequent to the date of this
Agreement and not exceeding an aggregate  principal balance of ***** at any time
outstanding,

     *****Confidential Treatment Requested

     (viii)  Investments  in the form of debt  securities  or other  evidence of
Indebtedness of Ramus Medical Technologies acquired or received on or subsequent
to the date of this Agreement pursuant to agreements or instruments in effect on
the  date of this  Agreement  and  having  an  aggregate  principal  amount  not
exceeding *****,

     *****Confidential Treatment Requested

     (ix) *****

     *****Confidential Treatment Requested

     (x) Investments  (including debt  obligations)  received in connection with
the bankruptcy or  reorganization of customers or suppliers and in settlement of
delinquent  obligations  of, and other  disputes  with,  customers  or suppliers
arising in the ordinary course of business,

     (xi)  Investments  pursuant  to or arising  under  currency  agreements  or
interest rate agreements entered into in the ordinary course of business,

     (xii)  Investments  consisting of notes receivable of, or prepaid royalties
and other credit extensions,  to customers and suppliers made or received in the
ordinary course of business, and

     (xiii)   Investments  in  the  form  of  deposit  accounts  and  marketable
securities made pursuant to the cash management policy adopted by the Borrower's
Board  of  Directors  and  furnished  to the  Lender  prior  to the date of this
Agreement.

     (f) Capital Expenditures.  Make any Capital Expenditures,  or permit any of
its Subsidiaries to do so, exceeding ***** in the aggregate for the Borrower and
the Subsidiaries in any one calendar year;  provided that following the earliest
to occur of (i) *****

     *****Confidential Treatment Requested

     (g) Redemptions,  etc. Redeem,  defease (including but not limited to legal
or covenant defeasance),  repurchase,  retire or otherwise acquire or retire for
value  prior to any  scheduled  maturity,  repayment  or sinking  fund  payment,
Indebtedness,  other than Indebtedness to the Lender under the Credit Documents,
or permit any of its Subsidiaries to do so.

     (h)  Dividends  and Purchase of Stock.  Declare any  dividends  (other than
dividends  payable in capital  stock of the Borrower) on any shares of any class
of capital stock, or purchase,  acquire, redeem or retire, or apply any property
or assets to the purchase,  acquisition,  redemption  or  retirement  of, or set
apart  any  sum  for the  payment  of any  dividends  on,  or for the  purchase,
acquisition,  redemption or  retirement  of, or make any other  distribution  by
reduction  of capital  or  otherwise  in respect  of, any shares of any class of
capital  stock  of the  Borrower  or any of  its  Subsidiaries  or any  options,
warrants or rights to purchase or acquire  shares of any class of capital  stock
of the Borrower or any such Subsidiary,  or permit any of its Subsidiaries which
is not a Wholly Owned Subsidiary to do so, except that

     (i) the Borrower may purchase, redeem or otherwise acquire shares of Common
Stock  pursuant to any agreement  existing on the date hereof between it, or any
Subsidiary of the Borrower, and any officer, director, employee or consultant to
the Borrower or any of its  Subsidiaries,  in which the Borrower is obligated or
has the option to repurchase from such officer, director, employee or consultant
shares of Common  Stock upon such  Person's  termination  of  employment  or the
services with the Borrower or any such Subsidiary,

     (ii)  the  Borrower  may  convert,  exchange  or  redeem  any  Indebtedness
outstanding on the date hereof which by its terms is convertible or exchangeable
or constitutes the right to purchase any shares of any class of capital stock of
the Borrower,

     (iii)  *****

     *****Confidential Treatment Requested

     (iv) *****

     *****Confidential Treatment Requested

     (i) Stock of Subsidiaries.  Sell, pledge or otherwise dispose of any shares
of capital stock of any of its Subsidiaries  (except in connection with a merger
or  consolidation  of a Wholly Owned  Subsidiary  of the  Borrower  permitted by
Section  7.02(a) or with the  dissolution  of any Subsidiary of the Borrower) or
permit any of its  Subsidiaries to issue any additional  shares of capital stock
except pro rata to its stockholders.

     (j)  Distributions by  Subsidiaries.  Suffer to exist, or permit any of its
Subsidiaries  to suffer to exist,  any consensual  encumbrance or restriction on
the ability of any such Subsidiary (i) to pay, directly or indirectly, dividends
or make any other  distributions  in  respect  of its  capital  stock or pay any
Indebtedness or other obligation owed to the Borrower or any other Subsidiary of
the Borrower;  (ii) to make loans or advances to the Borrower or any  Subsidiary
of the  Borrower;  or (iii) to  transfer  any of its  property  or assets to the
Borrower.

     (k) Related  Agreements.  Amend,  modify or waive, or permit to be amended,
modified or waived, any provision of the Key Agreements unless,  within not less
than 30 days prior to such amendment, modification or waiver, the Borrower shall
have  given  the  Lender  notice  thereof,  including  all  relevant  terms  and
conditions thereof, and the Lender shall have consented in writing thereto.

     (l) Sale and  Leaseback  Transactions.  Enter  into,  or permit  any of its
Subsidiaries to enter into, any Sale and Leaseback Transaction.

     (m)  Transactions   with  Affiliates  and  Related  Persons.   Directly  or
indirectly  enter  into,  or  permit  any of its  Subsidiaries  to  directly  or
indirectly  enter  into,  on or  following  the  date  hereof,  any  transaction
(including,  without  limitation,  the  purchase,  sale,  lease or  exchange  of
property, the rendering of any service or the making of any loan or advance, but
excluding transactions between the Borrower and Wholly Owned Subsidiaries of the
Borrower)  with any  Affiliate  or Related  Person of the Borrower or any of its
Subsidiaries.

     (n) Asset  Dispositions.  Make any Asset Disposition,  or permit any of its
Subsidiaries to make any Asset Disposition, in one or more related transactions,
unless

     (i) the  Borrower  (or  such  Subsidiary,  as the  case  may  be)  receives
consideration  at the time of such disposition at least equal to the fair market
value of the shares or assets  disposed of (which shall be as determined in good
faith by the Board of Directors and evidenced by a resolution adopted thereby),

     (ii) the  consideration  for such  disposition  consists of cash or readily
marketable cash equivalents or the assumption of Indebtedness of the Borrower or
other obligations  relating to such assets and release from all liability on the
Indebtedness or other obligations assumed, and

     (iii)  ***** of the Net  Available  Asset  Disposition  Proceeds  from such
disposition (including from the sale of any marketable cash equivalents received
therein) are applied by the Borrower (or such  Subsidiary,  as the case may be),
within 48 hours of the  receipt  thereof,  to  prepayment  of Loans  pursuant to
Section 2.04.

     *****Confidential Treatment Requested

     (o) Securities Offerings.  Sell or offer to sell any securities,  or permit
any of its Subsidiaries to offer or sell any securities,  in one or more related
transactions, unless

     (i) the consideration for such disposition consists of cash, and

     (ii) ***** of the Net  Available  Securities  Offering  Proceeds  from such
offering or sale are applied by the  Borrower (or such  Subsidiary,  as the case
may be), within 48 hours of the receipt thereof, to prepayment of Loans pursuant
to Section 2.04.

     *****Confidential Treatment Requested

     (p) Surplus Cashflows. Fail to apply to the prepayment of Loans pursuant to
Section 2.04 at least ***** of the amount (the "Surplus") by which EBITDA in any
calendar quarter exceeds *****.

     *****Confidential Treatment Requested

     Section VII.3 Financial  Covenants.  Until  satisfaction in full of all the
obligations of the Borrower under the Credit Documents, the Borrower will not:

     (a) Shareholders' Equity. Permit Shareholders' Equity as of the last day of
any  calendar  quarter  designated  below to be less than the  amount  set forth
opposite such quarter below.


          Calendar quarter ending       Shareholders' Equity

          March 31, 1999                *****

          June 30, 1999                 *****

          September 30, 1999            *****

          December 31, 1999             *****

          March 31, 2000                *****

          June 30, 2000                 *****

          Each calendar quarter
          ending after June 30, 2000    *****


     *****Confidential Treatment Requested     

     (b)  Current  Ratio.   Permit  the  ratio  of  Current  Assets  to  Current
Liabilities to be less than ***** at any time.

     *****Confidential Treatment Requested

     (c) *****

     (d) *****

     *****Confidential Treatment Requested

                                  ARTICLE VIII

                                Events of Default

     Section VIII.1.  Events of Default.  If one or more of the following events
(each, an "Event of Default") shall occur:

     (a) the Borrower shall fail duly to pay any principal of any Loan when due,
whether at maturity, by notice of intention to prepay or otherwise; or

     (b) the  Borrower  shall  fail duly to pay any  interest,  fee or any other
amount  payable under the Credit  Documents  within five Business Days after the
same shall be due, in the manner set forth in this Agreement; or

     (c) the Borrower shall fail duly to observe or perform any term,  covenant,
or agreement contained in Section 7.02 or 7.03; or

     (d) the  Borrower  shall fail duly to observe  or perform  any other  term,
covenant or agreement  contained in this Agreement,  and such failure shall have
continued  unremedied  for a period of 30 days  following  written notice to the
Borrower thereof; or

     (e) any representation or warranty made or deemed made by the Borrower in a
Credit  Document,  or any statement or  representation  made in any certificate,
report or opinion delivered by or on behalf of the Borrower in connection with a
Credit  Document,  shall prove to have been false or  misleading in any material
respect when so made or deemed made; or

     (f)  the  Borrower  or  any  of  its  Subsidiary  shall  fail  to  pay  any
Indebtedness  (other than  obligations  hereunder) in an amount of ***** or more
when  due;  or any  such  Indebtedness  having  an  aggregate  principal  amount
outstanding  of ***** or more shall become or be declared to be due prior to the
expressed maturity thereof; or

     *****Confidential Treatment Requested

     (g) an involuntary case or other proceeding shall be commenced  against the
Borrower or any of its Subsidiaries seeking liquidation, reorganization or other
relief  with  respect  to it or  its  debts  under  any  applicable  bankruptcy,
insolvency,  reorganization  or similar  law or  seeking  the  appointment  of a
custodian,  receiver,  liquidator,  assignee,  trustee,  sequestrator or similar
official of it or any  substantial  part of its property,  and such  involuntary
case or other proceeding  shall remain  undismissed and unstayed for a period of
more  than 60 days;  or an order or  decree  approving  or  ordering  any of the
foregoing shall be entered and continued unstayed and in effect; or

     (h) the Borrower or any of its Subsidiaries shall commence a voluntary case
or proceeding under any applicable  bankruptcy,  insolvency,  reorganization  or
similar  law or any other case or  proceeding  to be  adjudicated  a bankrupt or
insolvent,  or any of them  shall  consent to the entry of a decree or order for
relief in respect of the Borrower or any such Subsidiary in an involuntary  case
or proceeding under any applicable  bankruptcy,  insolvency,  reorganization  or
other similar law or to the commencement of any bankruptcy or insolvency case or
proceeding  against any of them,  or any of them shall file a petition or answer
or consent seeking  reorganization or relief under any applicable law, or any of
them shall  consent to the filing of such petition or to the  appointment  of or
taking  possession  by a custodian,  receiver,  liquidator,  assignee,  trustee,
sequestrator  or similar  official of the Borrower or any such Subsidiary or any
substantial  part of their  respective  property,  or any of them  shall make an
assignment  for the benefit of creditors,  or any of them shall admit in writing
its inability to pay its debts  generally as they become due, or the Borrower or
any Subsidiary shall take corporate action in furtherance of any such action; or

     (i) one or more judgments  against the Borrower or any of its  Subsidiaries
or attachments against its property, which in the aggregate exceed *****, or the
operation or result of which could be to interfere materially and adversely with
the  conduct of the  business  of the  Borrower  or any such  Subsidiary  remain
unpaid, unstayed on appeal, undischarged,  unbonded, or undismissed for a period
of more than 30 days; or

     *****Confidential Treatment Requested

     (j) notice of intent to terminate a Pension Plan shall have been filed with
any  affected  party (as  defined  in Section  4001 of  ERISA),  or notice of an
application  by the PBGC to  institute  proceedings  to terminate a Pension Plan
pursuant to Section 4042 of ERISA shall have been  received by any member of the
ERISA Group, in each case only if the amount of unfunded benefit liabilities (as
defined in Section  4001(a)(18) of ERISA) as of the date such notice is filed or
received exceeds $500,000;  any member of the ERISA Group incurs liability under
Sections  4062(e),  4063 or 4064 of ERISA in  respect  of a  Pension  Plan in an
amount in excess of $1,000,000;  an amendment is adopted to a Pension Plan which
would  require  security to be given to such  Pension  Plan  pursuant to Section
401(a)(29)  of the Code or  Section  307 of  ERISA in an  amount  in  excess  of
$1,000,000;  any member of the ERISA  Group fails to make a payment to a Pension
Plan which would give rise to a Lien in favor of such Plan under Section  302(f)
of ERISA in an amount in excess of $500,000; or

     (k) any court or governmental  or regulatory  authority shall have enacted,
issued,  promulgated,   enforced  or  entered  any  statute,  rule,  regulation,
judgment,  decree, injunction or other order (whether temporary,  preliminary or
permanent)  which  is in  effect  and  which  prohibits,  enjoins  or  otherwise
restricts, in a manner that, individually or in the aggregate,  could reasonably
be  expected  to  have a  Material  Adverse  Effect,  any  of  the  transactions
contemplated under the Credit Documents; or

     (l) any person or group of persons  (within the meaning of Section 13 or 14
of the Securities  Exchange Act of 1934, as amended),  other than the Lender and
its  Affiliates  and  other  than  any  person  or group of  persons  which  has
beneficial  ownership of 5% or more of the outstanding shares of Common Stock as
of the date of this Agreement,  shall have acquired beneficial ownership (within
the meaning of Rule 13d-3 promulgated by the Securities and Exchange  Commission
under said Act) of 19.9% or more of the outstanding  shares of Common Stock; or,
during  any  period of 24  consecutive  calendar  months,  individuals  who were
directors  of the  Borrower  on the  first  day of such  period  shall  cease to
constitute a majority of the board of directors of the  Borrower;  then,  and at
any time during the  continuance  of such Event of  Default,  the Lender may, by
written  notice to the Borrower  declare any Loans then  outstanding  to be due,
whereupon  the  principal  of the Loans so  declared  to be due,  together  with
accrued  interest  thereon  and any  unpaid  amounts  accrued  under the  Credit
Documents,  shall become forthwith due, without presentment,  demand, protest or
any other  notice of any kind (all of which are hereby  expressly  waived by the
Borrower).

     Section VIII.2.  Assignments.  (a) Upon reasonable prior notice having been
given to the  Borrower,  the Lender may at any time assign to one or more of The
Pharmacia & Upjohn  Company,  Pharmacia & Upjohn B.V.,  Pharmacia & Upjohn AB or
Pharmacia & Upjohn S.p.A. (any such entity, an "Approved  Subsidiary") all, or a
proportionate  part of all, of its rights and obligations  under this Agreement,
and such Approved Subsidiary shall assume such rights and obligations,  pursuant
to a written instrument  executed by such Approved Subsidiary and the Lender. If
there shall have occurred an Event of Default that is continuing, the Lender may
assign to any Person,  other than a Person  which  engages in, as its  principal
business or one of its principal  businesses,  the development of photoselective
drugs or light producing and light delivery  medical devices (any such assignee,
or any Approved  Subsidiary  referred to in the previous sentence being referred
to as an  "Assignee"),  all, or a  proportionate  part of all, of its rights and
obligations under this Agreement, and such Assignee shall assume such rights and
obligations,  pursuant to a written instrument executed by such Assignee and the
Lender.  Any such  Assignee  shall have all the rights  and  obligations  of the
Lender,  and the Lender shall be released  from its  obligations  hereunder to a
corresponding  extent,  and no further  consent or action by any party  shall be
required.

     (b) No Assignee  of the  Lender's  rights  shall be entitled to receive any
greater  payment  under  Section  4.03 or 4.04 than the  Lender  would have been
entitled to receive with respect to the rights transferred,  and amounts payable
under this Agreement  shall not be increased in respect of any Taxes required to
be withheld or deducted  solely as a  consequence  of the  Lender's  status as a
nonresident alien, as such term is defined in the Code.

     Section VIII.3.  Certain  Pledges.  Notwithstanding  any other provision in
this  Agreement,  any Lender may at any time create a security  interest  in, or
pledge,  all or any portion of its rights under this Agreement and any Note held
by it in favor of any Person.


                                   ARTICLE IX

                                  Miscellaneous

     SECTION  IX.1.  APPLICABLE  LAW.  THIS  AGREEMENT  SHALL BE GOVERNED BY AND
CONSTRUED IN  ACCORDANCE  WITH THE LAWS OF THE STATE OF NEW YORK  APPLICABLE  TO
CONTRACTS MADE AND TO BE PERFORMED ENTIRELY WITHIN SUCH STATE.

     SECTION  IX.2.  WAIVER OF JURY.  THE  BORROWER  AND THE LENDER  EACH HEREBY
WAIVES  TRIAL  BY  JURY  IN  ANY  JUDICIAL  PROCEEDING  INVOLVING,  DIRECTLY  OR
INDIRECTLY,  ANY MATTER (WHETHER SOUNDING IN TORT, CONTRACT OR OTHERWISE) IN ANY
WAY ARISING OUT OF, RELATED TO, OR CONNECTED WITH THIS  AGREEMENT,  THE NOTES OR
THE RELATIONSHIPS ESTABLISHED HEREUNDER.

     Section IX.3.  Jurisdiction and Venue; Service of Process. (a) The Borrower
and the Lender each hereby irrevocably submits to the non-exclusive jurisdiction
of any state or federal court in the Borough of Manhattan,  The City of New York
for the  purpose of any suit,  action,  proceeding  or  judgment  relating to or
arising out of any Credit  Document and to the laying of venue in the Borough of
Manhattan,  The City of New  York.  The  Borrower  and the  Lender  each  hereby
irrevocably  waives,  to the fullest  extent  permitted by  applicable  law, any
objection  to the  laying of the venue of any such  suit,  action or  proceeding
brought in the aforesaid courts and hereby irrevocably waives any claim that any
such suit, action or proceeding brought in any such court has been brought in an
inconvenient forum.

     (b) The  Borrower  agrees  that  service of  process in any such  action or
proceeding  may be effected by mailing a copy thereof by registered or certified
mail (or any  substantially  similar  form of  mail),  postage  prepaid,  to the
Borrower at its address  set forth in Section  9.07 or at such other  address of
which the Lender shall have been notified pursuant thereto. The Borrower further
agrees that nothing  herein shall affect the right to effect  service of process
in any other  manner  permitted by law or shall limit the right to sue any other
jurisdiction.

     (c) Each of the Borrower and the Lender  waives,  to the maximum extent not
prohibited by law, any right it may have to claim or recover in any legal action
or proceeding referred to in this Section 9.03 any special, exemplary,  punitive
or  consequential  damages.  The waiver set forth in this Section  9.03(c) shall
terminate  automatically  upon the occurrence of a "Separation Event" as defined
in that certain  stockholder rights protection plan of Pharmacia & Upjohn,  Inc.
in effect on the date of this Agreement, as it may from time to time be amended.

     Section IX.4.  Set-off.  The Borrower hereby authorizes the Lender and each
of its  Affiliates,  upon the  occurrence of an Event of Default and at any time
and from time to time during the  continuance  thereof,  to the  fullest  extent
permitted  by law, to set-off and apply any and all sums  payable by such Lender
or any such Affiliate to or for the credit or the account of the Borrower or any
of its Affiliates  against any of the  obligations of the Borrower or any of its
Affiliates, now or hereafter existing under any Credit Document, irrespective of
whether the Lender shall have made any demand under this  Agreement and although
such  obligations may be unmatured.  The rights of the Lender and its Affiliates
under this Section 9.04 are in addition to other rights and remedies  (including
other rights of set-off) which the Lender and its Affiliates may have.

     Section IX.5.  Amendments and Waivers.  (a) Any provision of this Agreement
may be  amended,  modified,  supplemented  or  waived,  but  only  by a  written
amendment  or  supplement,  or written  waiver,  signed by the  Borrower and the
Lender.
     (b) Except to the extent  expressly set forth therein,  any waiver shall be
effective only in the specific  instance and for the specific  purpose for which
such waiver is given.

     Section IX.6. Cumulative Rights; No Waiver. Each and every right granted to
the  Lender  hereunder  or under  any other  document  delivered  in  connection
herewith,  or allowed the Lender by law or equity,  shall be cumulative  and not
exclusive and may be exercised  from time to time. No failure on the part of the
Lender to  exercise,  and no delay in  exercising,  any right will  operate as a
waiver  thereof,  nor will any single or partial  exercise  by the Lender of any
right preclude any other or future exercise thereof or the exercise of any other
right.

     Section IX.7. Notices. (a) Any communication,  demand or notice to be given
hereunder will be duly given when delivered in writing or by telecopy to a party
at its  address  as  indicated  below or such  other  address  as such party may
specify in a notice to each  other  party  hereto.  A  communication,  demand or
notice given pursuant to this Section 9.07 shall be addressed:

     If to the Borrower, to

                           Miravant Medical Technologies
                           7408 Hollister Avenue
                           Santa Barbara, California 93117

                           Telecopy:  (805) 685-6038

                           Attention:  Gary S. Kledzik


     with copies (which, in and of themselves, shall not constitute notice) to
                           Nida & Maloney PC
                           800 Anacapa Street
                           Santa Barbara, California 93101

                           Telecopy:  (805) 568-1955

                           Attention:  Joseph E. Nida

     and
                           Wilson Sonsini Goodrich & Rosati
                           650 Page Mill Road
                           Palo Alto, California 94304

                           Telecopy:  (650) 493-6811

                           Attention:  John T. Sheridan

     If to the Lender, to
                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:  (908) 470-8047

                           Attention:  Treasurer

     and

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:    (908) 306-4485

                         Attention:Senior Vice President of Business Development

     and


                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:            (908) 306-4489

                           Attention:           General Counsel

     with a copy (which, in and of itself, shall not constitute notice) to
                           Sullivan & Cromwell
                           125 Broad Street
                           New York, New York 10004

                           Telecopy:  (212) 558-3588

                           Attention:  Neil T. Anderson,
                                              Matthew G. Hurd
                                              and Martin J. Travers

     This Section  9.07 shall not apply to notices  referred to in Article II of
this Agreement, except to the extent set forth therein.

     (b) Unless otherwise  provided to the contrary herein,  any notice which is
required to be given in writing  pursuant to the terms of this  Agreement may be
given by telecopy.

     Section IX.8.  Certain  Acknowledgments.  The Borrower  hereby confirms and
acknowledges that the Lender does not have any fiduciary or similar relationship
to the Borrower and that the  relationship  established by the Credit  Documents
between the Lender and the  Borrower  is solely that of creditor  and debtor and
(b) that no joint venture exists between the Borrower and the Lender.

     Section  IX.9.  Separability.  In case  any  one or more of the  provisions
contained in any Credit Document shall be invalid,  illegal or  unenforceable in
any respect  under any law, the  validity,  legality and  enforceability  of the
remaining  provisions contained herein or in any other Credit Document shall not
in any way be affected or impaired thereby.

     Section IX.10.  Parties in Interest.  This Agreement  shall be binding upon
and inure to the  benefit of the  Borrower  and the Lender and their  respective
successors  and  assigns,  except  that the  Borrower  may not assign any of its
rights  hereunder  without  the prior  written  consent of the  Lender,  and any
purported assignment by the Borrower without such consent shall be void.

     Section IX.11. Execution in Counterparts. This Agreement may be executed in
any number of  counterparts  and by the  different  parties  hereto on  separate
counterparts, each of which when so executed and delivered shall be an original,
but all the counterparts shall together constitute one and the same instrument.

     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed as of the date first above written.

                                            MIRAVANT MEDICAL TECHNOLOGIES


                                            By:________________________________
                                               Name:
                                               Title:


                                       

                                            By:________________________________
                                               Name:
                                               Title:

                          Subsidiaries of the Borrower

                                                                     Exhibit A



                                             Form of Borrowing Request


                                                            [Date]*



Pharmacia & Upjohn, Inc.
95 Corporate Drive
Bridgewater, New Jersey 08807

Attention:  Treasurer

                                                 Borrowing Request


Ladies and Gentlemen:

     Reference is made to the Credit Agreement, dated as of o, 1999 (as amended,
modified or  supplemented  from time to time, the "Credit  Agreement"),  between
Miravant  Medical  Technologies  and o.  Capitalized  terms used  herein and not
otherwise  defined herein shall have the meanings  ascribed to such terms in the
Credit Agreement.

     The Borrower  hereby gives you notice,  pursuant to Section  2.02(a) of the
Credit Agreement,  that it requests a Quarterly Loan in a principal amount equal
to the Borrowing  Amount set forth below,  to be made on the Borrowing  Date set
forth below.

                  Borrowing Date:**                           _________, ____

                  Borrowing Amount:***                           $___________

                                     A-4

                  Warrant Number:****                          ___________

     A duly  executed  Note in the form of  Exhibit B to the  Credit  Agreement,
dated as of the Borrowing  Date set forth above and  evidencing a Quarterly Loan
in a  principal  amount  equal to the  Borrowing  Amount  set  forth  above,  is
enclosed.

     A duly executed Warrant  Certificate  evidencing a number of Warrants equal
to the Warrant  Number is enclosed.  The Exercise Price for each such Warrant is
$______,  and the closing bid prices for the 10 Trading Days  preceding this bid
request and a calculation of the Exercise Price are set out below.  The Exercise
Price is the sum of [A] plus [B].


                  Trading Day                        Closing Bid Price

          1.                                                  $
          2.
          3.
          4.
          5.
          6.
          7.
          8.
          9.
         10.                                                           
                                            Total    ____________________
                                            / 10     ____________________ [A]
                                            x 0.40   ____________________ [B]
                                        [A]+[B]      ____________________


                                            Very truly yours,

                                            MIRAVANT MEDICAL TECHNOLOGIES


                                            By:                                
                                               Name:
                                               Title:




                                  Form of Note

                                 PROMISSORY NOTE


$[Principal Amount]                                                    [Date]


                  MIRAVANT  MEDICAL  TECHNOLOGIES,  a Delaware  corporation (the
"Borrower"),  for  value  received,  promises  to  pay to  the  order  of o (the
"Lender"), on [MATURITY DATE], the principal sum of $[PRINCIPAL AMOUNT] pursuant
to and in the manner contemplated by that certain Credit Agreement,  dated as of
o, 1999 (as amended,  modified or  supplemented  from time to time,  the "Credit
Agreement"), between the Borrower and the Lender.

                  The  Borrower  also  promises  to pay  interest  on the unpaid
principal  amount  hereof  from time to time  outstanding,  from the date hereof
until the date of  repayment,  at the rate or rates per annum and on the date or
dates determined pursuant to the Credit Agreement.

                  Payments  of both  principal  and  interest  are to be made in
lawful money of the United States of America in funds  immediately  available to
the Lender at its office or offices  designated  in  accordance  with the Credit
Agreement,  or, if and only if specifically  permitted by Section 2.01(b) of the
Credit Agreement, in the manner set forth in such Section 2.01(b).

                  All  parties  hereto,   whether  as  makers,   endorsers,   or
otherwise, severally waive diligence, presentment, demand, protest and notice of
any kind whatsoever. The failure or forbearance by the holder to exercise any of
its rights  hereunder in any particular  instance shall in no event constitute a
waiver thereof.

                  The Credit Agreement,  among other things, contains provisions
for the acceleration of the maturity hereof upon the happening of certain events
and for the amendment or waiver of certain  provisions  of the Credit  Agreement
and/or  this  Note,  all  upon  the  terms  and  conditions  therein  specified.
Capitalized  terms  used and not  otherwise  defined  herein  have the  meanings
ascribed thereto in the Credit Agreement.

                  THIS NOTE HAS BEEN  DELIVERED IN NEW YORK,  NEW YORK AND SHALL
BE DEEMED TO BE A CONTRACT  MADE UNDER,  GOVERNED BY AND CONSTRUED IN ACCORDANCE
WITH THE LAWS OF THE STATE OF NEW YORK.

                         B-[PG NUMBER]


                  This Note is not  negotiable and may be assigned only upon the
terms and conditions specified in the Credit Agreement.

                          MIRAVANT MEDICAL TECHNOLOGIES


                                                     By:                      
                                                        Name:
                                                        Title:
                                                                        
                                 Exhibit C

                   Form of Opinion of Counsel for the Borrower
                     to be Delivered Upon Payment of Shares














                                                      [TO COME]


                       Form of Opinion of Counsel for the
                 Borrower to be Delivered at the Effective Time


                                    [Effective Date]



Pharmacia & Upjohn, Inc.
95 Corporate Drive
Bridgewater, New Jersey 08807

Ladies and Gentlemen:

                  In connection  with the  execution  and delivery  today of the
Credit Agreement, dated as of o, 1999 (the "Credit Agreement"), between Miravant
Medical  Technologies,  Inc., a Delaware corporation (the "Borrower"),  and o, a
Swedish corporation (the "Lender"), the Security Agreement,  dated as of o, 1999
(the "Security  Agreement"),  among the Borrower,  as debtor, and the Lender, as
Secured Party, and [add references to other Credit Documents] (collectively with
the Credit Agreement and the Security Agreement, the "Credit Documents"), we, as
counsel for the Borrower, have examined such corporate records, certificates and
other documents,  and such questions of law, as we have considered  necessary or
appropriate  for  the  purposes  of  this  opinion.   Upon  the  basis  of  such
examination, it is our opinion that:

                  (1) The Borrower has been duly incorporated and is an existing
         corporation in good standing under the laws of the State of Delaware.

                  (2) Each of the  Credit  Documents  has been duly  authorized,
         executed and delivered, and, if and when duly executed and delivered in
         accordance  with the terms of the Credit  Agreement,  any Notes will be
         duly  authorized,  executed and delivered by the Borrower;  and each of
         the Credit Documents (other than any Notes) constitutes,  and each Note
         (if and when duly executed and  delivered in accordance  with the terms
         of the Credit Agreement) will constitute, the valid and legally binding
         obligation  of  the  Borrower   enforceable  in  accordance   with  its
         respective  terms,  subject  to  bankruptcy,   insolvency,   fraudulent
         transfer,  reorganization,  moratorium  and  similar  laws  of  general
         applicability relating to or affecting creditors' rights and to general
         equity principles.

                             D-[PG NUMBER]


                  (3)  [Opinion on the Warrants and Exercise Shares]

                  (4) All  regulatory  consents,  authorizations,  approvals and
         filings  required  to be  obtained  or made by the  Borrower  under the
         Federal laws of the United States and the laws of the State of New York
         for the  borrowing  by the  Borrower  from the Lender  under the Credit
         Agreement,  the execution and delivery of each of the Credit  Documents
         to the Lender and the  performance  by the  Company of its  obligations
         thereunder have been obtained or made; provided, however, that, insofar
         as  performance  by the Borrower of its  obligations  under each of the
         Credit Documents is concerned,  we express no opinion as to bankruptcy,
         insolvency, fraudulent transfer, reorganization, moratorium and similar
         laws of  general  applicability  relating  to or  affecting  creditors'
         rights or as to general equity principles.

                  (5) The Borrower is not an  "investment  company" or a company
         "controlled"  by an  "investment  company"  within  the  meaning of the
         Investment Company Act of 1940.

                  For  purposes  of this  letter,  terms  defined  in the Credit
Agreement have the meanings set forth therein.

                  The  foregoing  opinion is limited to the Federal  laws of the
United  States and the laws of the State of New York,  and we are  expressing no
opinion as to the effect of the laws of any other jurisdiction.

                  With your  approval,  we have relied as to certain  matters on
information  obtained from public officials,  officers of the Borrower and other
sources  believed by us to be responsible,  and we have assumed that each of the
Credit Documents has been duly authorized, executed and delivered by the parties
thereto other than the Borrower and its  Affiliates,  and that the signatures on
all  documents  examined  by us are  genuine,  assumptions  which  we  have  not
independently verified.


                  This letter is  delivered by us as counsel for the Borrower to
you, and is solely for your benefit.

                                                     Very truly yours,



                                                     NIDA & MALONEY PC



                         Form of Compliance Certificate

                             COMPLIANCE CERTIFICATE

                    [For the Fiscal Quarter ending ________]

                      [For the Fiscal Year ending ________]


                  Reference is made to the Credit Agreement, dated as of o, 1999
(as  amended,   modified  or  supplemented   from  time  to  time,  the  "Credit
Agreement"),  between  Miravant  Medical  Technologies  (the  "Borrower") and o.
Pursuant  to Section  7.01(a)(iii)  of the  Credit  Agreement,  the  undersigned
Responsible  Officer of the Borrower hereby  certifies on behalf of the Borrower
that:

                  (a)  During  the period of four  consecutive  fiscal  quarters
ended on ____________, __, such Responsible Officer has obtained no knowledge of
any Default or Event of Default except as follows: [Specify with particularity].

                  The financial statements referred to in Section 7.01(a) of the
Credit  Agreement  which are  delivered  concurrently  with the delivery of this
Compliance  Certificate  fairly  present  the  financial  position,  results  of
operations,  cash flows and changes in shareholders'  equity of the Borrower and
its  Subsidiaries,  subject to normal year-end audit  adjustments  which are not
expected to be material in amount.*

                  (b) The covenant calculations set forth below are based on the
Borrower's  [audited]  balance sheet and statements of earnings,  cash flows and
shareholders'  equity for the fiscal  [quarter] [year] ended  ___________,  ____
(the "Period-End Date").



[Insert calculations demonstrating compliance with Section 7.03 of the Credit 
Agreement]

         IN WITNESS  WHEREOF,  on behalf of the Borrower,  the  undersigned  has
hereto set his or her hand.


Dated:_________, ___

                                            MIRAVANT MEDICAL TECHNOLOGIES



                                            By: _______________________________
                                                A Responsible Officer




                                CREDIT AGREEMENT

                                   dated as of

                                     o, 1999

                                     between

                          MIRAVANT MEDICAL TECHNOLOGIES

                                       and

                                        o




                                        -vii-
                                                  TABLE OF CONTENTS

                                                                              
<TABLE>
<S>     <C>                                                                                                      <C>    



                              ARTICLE IDefinitions


Section 1.01.  Definitions........................................................................................1
         (a)      Terms Generally.................................................................................1
         (b)      Accounting Terms................................................................................2
         (c)      Other Terms.....................................................................................2


                          ARTICLE IIThe Credit Facility


Section 2.01.  Loans.............................................................................................15
Section 2.02.  Borrowing Procedure...............................................................................16
Section 2.03.  Repayment.........................................................................................16
Section 2.04.  Prepayment........................................................................................17


                               ARTICLE IIIInterest


Section 3.01.  Interest on Loans.................................................................................18
Section 3.02.  Interest on Overdue Amounts.......................................................................19
Section 3.03.  Day Counts........................................................................................19
Section 3.04.  Maximum Interest Rate.............................................................................19


                       ARTICLE IVDisbursement and Payment


Section 4.01.  Method and Time of Payments.......................................................................20
               ---------------------------
Section 4.02.  Compensation for Losses...........................................................................20
               -----------------------
Section 4.03.  Withholding.......................................................................................21
               -----------
Section 4.04.  Expenses; Indemnity...............................................................................21
               -------------------
Section 4.05.  Survival..........................................................................................22
               --------


                     ARTICLE VRepresentations and Warranties


Section 5.01.  Representations and Warranties....................................................................23
               ------------------------------
         (a)      Subsidiaries...................................................................................23
                  ------------
         (b)      Good Standing and Power........................................................................23
                  -----------------------
         (c)      Corporate Authority............................................................................23
                  -------------------
         (d)      Authorizations.................................................................................23
                  --------------
         (e)      Binding Obligation.............................................................................23
                  ------------------
         (f)      Litigation.....................................................................................24
                  ----------
         (g)      No Conflicts...................................................................................24
                  ------------
         (h)      Financial Condition............................................................................24
                  -------------------
         (i)      Taxes..........................................................................................25
                  -----
         (j)      Use of Proceeds................................................................................25
                  ---------------
         (k)      Margin Regulations.............................................................................25
                  ------------------
         (l)      Compliance with ERISA..........................................................................25
                  ---------------------
         (m)      Not an Investment Company......................................................................26
                  -------------------------
         (n)      Properties.....................................................................................26
                  ----------
         (o)      Compliance with Laws and Charter Documents.....................................................26
                  ------------------------------------------
         (p)      Environmental Protection.......................................................................27
                  ------------------------
         (q)      Insurance......................................................................................28
                  ---------
         (r)      Adverse Contracts..............................................................................28
                  -----------------
         (s)      Solvency.......................................................................................28
                  --------
         (t)      Disclosure.....................................................................................28
                  ----------
Section 5.02  Survival...........................................................................................29


                         ARTICLE VIConditions Precedent


Section 6.01.  Conditions to the Availability of the
                           Commitment............................................................................29
                           ----------
         (a)      This Agreement.................................................................................29
                  --------------
         (b)      Evidence of Corporate Action...................................................................29
                  ----------------------------
         (c)      Opinions of Counsel............................................................................30
                  -------------------
         (d)      Representations and Warranties.................................................................30
                  ------------------------------
         (e)      Other Documents................................................................................30
                  ---------------
Section 6.02.  Conditions to All Quarterly Loans.................................................................30
               ---------------------------------
         (a)      Borrowing Request..............................................................................30
                  -----------------
         (b)      Note...........................................................................................30
                  ----
         (c)      Warrant Certificate............................................................................30
                  -------------------
         (d)      No Default.....................................................................................31
                  ----------
         (e)      Representations and Warranties; Covenants......................................................31
                  -----------------------------------------
Section 6.03.  Satisfaction of Conditions Precedent..............................................................31


                              ARTICLE VIICovenants


Section 7.01.  Affirmative Covenants.............................................................................31
               ---------------------
         (a)      Financial Statements; Compliance Certificates..................................................31
                  ---------------------------------------------
         (b)      Corporate Existence............................................................................33
                  -------------------
         (c)      Conduct of Business............................................................................33
                  -------------------
         (d)      Authorizations.................................................................................33
                  --------------
         (e)      Taxes..........................................................................................34
                  -----
         (f)      Insurance......................................................................................34
                  ---------
         (g)      Inspection.....................................................................................34
                  ----------
         (h)      Maintenance of Records.........................................................................34
                  ----------------------
         (i)      Maintenance of Property........................................................................35
                  -----------------------
         (j)      ERISA..........................................................................................35
                  -----
         (k)      Notice of Defaults and Adverse Developments....................................................36
                  -------------------------------------------
         (l)      Environmental Matters..........................................................................37
                  ---------------------
Section 7.02.  Negative Covenants................................................................................37
               ------------------
         (a)      Mergers, Consolidations and Sales of Assets....................................................37
                  -------------------------------------------
         (b)      Liens..........................................................................................38
                  -----
         (c)      Indebtedness...................................................................................38
                  ------------
         (d)      Contingent Liabilities.........................................................................38
                  ----------------------
         (e)      Loans and Investments..........................................................................39
                  ---------------------
         (f)      Capital Expenditures...........................................................................40
                  --------------------
         (g)      Redemptions, etc...............................................................................41
                  -----------------
         (h)      Dividends and Purchase of Stock................................................................41
                  -------------------------------
         (i)      Stock of Subsidiaries..........................................................................42
                  ---------------------
         (j)      Distributions by Subsidiaries..................................................................42
                  -----------------------------
         (k)      Related Agreements.............................................................................42
                  ------------------
         (l)      Sale and Leaseback Transactions................................................................43
                  -------------------------------
         (m)      Transactions with Affiliates and Related Persons...............................................43
                  ------------------------------------------------
         (n)      Asset Dispositions.............................................................................43
                  ------------------
         (o)      Securities Offerings...........................................................................43
                  --------------------
         (p)      Surplus Cashflows..............................................................................44
                  -----------------
Section 7.03  Financial Covenants................................................................................44
              -------------------
         (a)      Shareholders' Equity...........................................................................44
                  --------------------
         (b)      Current Ratio..................................................................................44
                  -------------
         (c)      Minimum Operating Income.......................................................................44
                  ------------------------
         (d)      Ophthalmology Expense..........................................................................44
                  ---------------------


                          ARTICLE VIIIEvents of Default


Section 8.01.  Events of Default.................................................................................45
               -----------------
         (a)      ...............................................................................................45
         (b)      ...............................................................................................45
         (c)      ...............................................................................................45
         (d)      ...............................................................................................45
         (e)      ...............................................................................................45
         (f)      ...............................................................................................45
         (g)      ...............................................................................................45
         (h)      ...............................................................................................46
         (i)      ...............................................................................................46
         (j)      ...............................................................................................46
         (k)      ...............................................................................................47
         (l)      ...............................................................................................47
Section 8.02.  Assignments.......................................................................................47
         (b)      ...............................................................................................48
Section 8.03.  Certain Pledges...................................................................................48


                             ARTICLE IXMiscellaneous


SECTION 9.01.  APPLICABLE LAW....................................................................................48
               --------------
SECTION 9.02.  WAIVER OF JURY....................................................................................49
               --------------
Section 9.03.  Jurisdiction and Venue; Service of Process........................................................49
               ------------------------------------------
Section 9.04.  Set-off...........................................................................................49
               -------
Section 9.05.  Amendments and Waivers............................................................................50
               ----------------------
Section 9.06.  Cumulative Rights; No Waiver......................................................................50
               ----------------------------
Section 9.07.  Notices...........................................................................................50
               -------
Section 9.08.  Certain Acknowledgments...........................................................................52
               -----------------------
Section 9.09.  Separability......................................................................................52
               ------------
Section 9.10.  Parties in Interest...............................................................................52
               -------------------
Section 9.11.  Execution in Counterparts.........................................................................53
               -------------------------



                                                      SCHEDULES


Schedule 5.01(a)           Subsidiaries of the Borrower



                                                      EXHIBITS

Exhibit A                   Form of Borrowing Request

Exhibit B                   Form of Note

Exhibit C                   Form of Opinion of Counsel for the Borrower to be Delivered Upon Payment of Shares

Exhibit D                   Form of Opinion of Counsel for the Borrower to be Delivered at the Effective Time

Exhibit E                   Form of Compliance Certificate



- --------
*        See Section 2.02 the Credit Agreement.
**       See the definition of "Borrowing Date" in Section 1.01(c) of the Credit Agreement.
***      See Section 2.01 and the definition of "Maximum Quarterly Amount" in Section 1.01(c) of the Credit Agreement.
****     See the definition of "Warrant Number" in Section 1.01(c) of the Credit Agreement.
*        Insert only in Compliance Certificates accompanying quarterly financial statements delivered pursuant to Section 7.01(a) of
         the Credit Agreement.

</TABLE>


                                   
                         WARRANT AGREEMENT


     WARRANT AGREEMENT (this "Agreement"), dated as of o, 1999, between MIRAVANT
MEDICAL  TECHNOLOGIES,  a Delaware corporation (the "Company"),  and PHARMACIA &
UPJOHN, INC., a Delaware corporation (the "Initial Holder").

                              W I T N E S S E T H :


     WHEREAS,  Sections 2.02 and 6.02(b) of the Credit  Agreement,  of even date
herewith,  between the Company and o (the  "Credit  Agreement")  provide that in
connection with the making of each Borrowing Request  contemplated  thereby, the
Company shall deliver to the Initial Holder a Warrant Certificate representing a
number of Warrants  equal to the Warrant  Number and having the terms herein set
forth;

                  NOW, THEREFORE, the parties agree as follows:

                                   ARTICLE 1

                                   Definitions

     Section I.1. Terms  Generally.  The  definitions  ascribed to terms in this
Agreement  apply  equally to both the  singular  and plural forms of such terms.
Whenever  the context may  require,  any pronoun  shall be deemed to include the
corresponding  masculine,  feminine  and  neuter  forms.  The  words  "include",
"includes"  and  "including"  shall be  interpreted as if followed by the phrase
"without limitation". All references herein to the Preamble, Recitals, Articles,
Sections and Exhibits  shall be deemed  references to the Preamble and Recitals,
Articles and Sections  of, and  Exhibits to, this  Agreement  unless the context
shall  otherwise  require.  The headings and captions  herein shall not be given
effect in interpreting or construing the provisions of this Agreement. Except as
otherwise expressly provided herein, all references to "dollars" or "$" shall be
deemed references to the lawful money of the United States of America.

     Section I.2. Definitions. The following terms have the meanings ascribed to
them below:

     "Affiliate"  of any Person  means any other Person  directly or  indirectly
controlling  or  controlled by or under direct or indirect  common  control with
such Person.  For purposes of this definition,  "control" when used with respect
to any Person  means the power to direct the  management  and  policies  of such
Person,  directly  or  indirectly,  whether  through  the  ownership  of  voting
securities,   by  contract  or  otherwise,   and  the  terms  "controlling"  and
"controlled" have meanings correlative to the foregoing.

     "Average Price" means,  with respect to the Exercise Price for any Warrant,
the average of the Closing  Prices of the Common  Stock for the 10 Trading  Days
immediately  preceding  the date of the  dispatch to the  Initial  Holder of the
Borrowing  Request that  accompanies  the Warrant  Certificate  evidencing  such
Warrant.

     "Board of Directors" means the board of directors of the Company.

     "Borrowing  Request"  has the  meaning  assigned to such term in the Credit
Agreement.

     "Business Day" means any day that is not a Saturday, Sunday or other day on
which commercial banks in The City of New York or in Los Angeles, California are
authorized by law to close.

     "Cash Amount" means,  with respect to any Warrant,  an amount of cash equal
to the  product of (i) 95% of the  Closing  Price of the Common  Stock as of the
date of exercise of such Warrant  multiplied by (ii) the Shares Amount in effect
on such date.

     "Close of Business"  means,  for any day, 5:00 p.m., New York City time, on
such date.

     "Closing  Price" means the last  reported sale price regular way on the day
in  question  or, in case no such sale  takes  place on such day,  the  reported
closing bid price regular way of the Common Stock, in each case on the principal
national  securities exchange on which the Common Stock is listed or admitted to
trading,  or, if not listed or  admitted to trading on any  national  securities
exchange,  the  closing  bid price of the Common  Stock on the  Nasdaq  National
Market,  or if not listed or  admitted  to trading  on any  national  securities
exchange and not quoted on the Nasdaq National Market,  the closing bid price of
the  Common  Stock in the  over-the-counter  market  on the day in  question  as
reported by the National Quotation Bureau Incorporated, or a similarly generally
accepted reporting service, or, if not so available in such manner, as furnished
by any New York Stock  Exchange,  Inc. member firm selected from time to time by
the Board of  Directors  for such  purpose.  In the case of a  closing  price of
Common Stock on the Nasdaq  National  Market  System,  such price shall mean the
closing price  reported in the New York City edition of The Wall Street  Journal
or, if not so reported, another authoritative source.

     "Commission" means the Securities and Exchange Commission (or any successor
Governmental Authority).

     "Common  Stock" means the common  stock,  par value $.01 per share,  of the
Company and any other stock of the Company  into which such common  stock may be
converted or  reclassified  (other than stock of the Company into which unissued
Common  Stock has been  reclassified)  or that may be issued in  respect  of, in
exchange  for, or in  substitution  of, such common stock by reason of any stock
splits,    stock    dividends,    distributions,     mergers,    consolidations,
recapitalizations or other like events.

     "Exchange Act" means the Securities Exchange Act of 1934, as amended.

     "Exercise  Price"  means,  with respect to any Warrant,  the price equal to
140% of the Average Price.

     "Expiration  Date"  means,   with  respect  to  each  Warrant,   the  fifth
anniversary of the date on which a Warrant  Certificate  evidencing such Warrant
is first received by the Initial  Holder,  provided that if such  anniversary is
not a Business Day, the next Business Day thereafter.

     "Governmental Authority" means any nation or government, any state or other
political subdivision thereof and any entity exercising executive,  legislative,
judicial, regulatory or administrative functions of or pertaining to government.

     "Holder" means any holder from time to time of Warrant Certificates.

     "Person" means any  individual,  sole  proprietorship,  partnership,  joint
venture,   trust,   unincorporated   organization,   association,   corporation,
institution,  public benefit corporation, entity or government (whether Federal,
state,  county,  city,  municipal or otherwise,  including any  instrumentality,
division, agency, body or department thereof).

     "Quarterly  Loan"  has the  meaning  assigned  to such  term in the  Credit
Agreement.

     "SEC Reports" means the annual and quarterly  reports and the  information,
documents,  and other  reports  that the  Company is  required  to file with the
Commission pursuant to Section 13(a) or 15(d) of the Exchange Act.

     "Securities Act" means the Securities Act of 1933, as amended.

     "Shares  Amount"  means,  with respect to any Warrant,  one share of Common
Stock,  subject to all adjustments made pursuant to Article V hereof on or prior
to the date of exercise of such Warrant.

     "Trading  Day"  means a day on  which  the  principal  national  securities
exchange  on which the shares of Common  Stock are listed or admitted to trading
is open for the  transaction  of business  or, if the shares of Common Stock are
not listed or admitted to trading on any national securities  exchange, a day on
which the Nasdaq National Market is open for the transaction of business.

     "Warrant"  means a warrant to purchase Common Stock at a price per share of
Common Stock equal to the Exercise Price for such Warrant.

     "Warrant  Number"  has the  meaning  assigned  to such  term in the  Credit
Agreement.

     Section I.3. Tie Sheet. The following terms are defined in the Sections set
forth below:
                  Term                                   Section
                  ----                                   -------
Agreement                                                Preamble
Applicable Price                                         5.06
Call Notice                                              3.07(b)
Called Warrants                                          3.07(a)
Common Stock Fundamental Change                          5.06
Company                                                  Preamble
Credit Agreement                                         Recitals
Current Event                                            5.01(g)
Expiration Time                                          5.01(f)
Indemnitee                                               9.02
Initial Holder                                           Preamble
Non-Stock Fundamental Change                             5.06
Other Event                                              5.01(g)
Purchased Shares                                         5.01(f)
Purchaser Stock Price                                    5.06
Reference Date                                           5.01(d)
Registrar                                                2.04(a)
Transfer Agent                                           7.01
Trigger Date                                             3.07(a)
Warrant Certificates                                     2.02
Warrant Register                                         2.04(a)


                                   ARTICLE II

                         Issuance and Grant of Warrants;
                          Form, Execution, Delivery and
                      Registration of Warrant Certificates

     Section  II.1.  Issuance  and Grant of  Warrants.  In  connection  with the
delivery by the Company of each  Borrowing  Request  pursuant to Section 2.02 of
the Credit  Agreement,  the Company will issue and grant to the Initial Holder a
number of Warrants  equal to the Warrant  Number.  In the event that the Company
has complied with its obligations  pursuant to the Credit  Agreement and o fails
to make the Quarterly Loan contemplated by Section 2.02 of the Credit Agreement,
the Warrants  evidenced by the Warrant  Certificate that accompanies the related
Borrowing Request shall be null and void; provided,  however, that if o fails to
make such Quarterly Loan as a result of the Company's cancellation or revocation
of such Borrowing Request or as a result of the Company's failure to comply with
its  obligations  under the Credit  Agreement,  such  Warrants  and such Warrant
Certificate shall not be rendered null, void or otherwise invalid.

     Section II.2. Form of Warrant Certificates. The certificates evidencing the
Warrants (the "Warrant  Certificates")  shall be in registered form only, in the
form set  forth in  Exhibit  A hereto  and may  represent  any  whole  number of
Warrants.  Each  Warrant  Certificate  shall be dated the date of the  Borrowing
Request  accompanying  such  Warrant  Certificate  and  may  have  imprinted  or
otherwise   reproduced   thereon  such  letters,   numbers  or  other  marks  of
identification  as may,  consistent  with the provisions of this  Agreement,  be
determined by the officers executing any such Warrant Certificate.

     Section II.3. Execution and Delivery of Warrant Certificates.  Each Warrant
Certificate  shall be  executed  on behalf of the  Company by (a) its  chairman,
chief executive  officer,  president,  or chief operating  officer,  and (b) its
chief financial officer,  in any case either manually or by facsimile  signature
printed thereon.

     Section II.4.  Registration;  Registration of Transfers and Exchanges.  (a)
The  Company  will keep a  register  or  registers  in which the  Company  shall
maintain a master  list of names and  addresses  of the  Holders  (the  "Warrant
Register")  and shall  provide  for the  registration  of, and  registration  of
transfer and exchange of, Warrant Certificates as provided in this Article. Each
person designated by the Company from time to time as a person having custody of
the Warrant  Register  and  register  the  transfer  and exchange of the Warrant
Certificates  is  hereinafter   called,   individually  and  collectively,   the
"Registrar".  The Company  hereby  appoints the Chief  Financial  Officer of the
Company as Registrar.  Upon written  notice to the Initial Holder and any acting
Registrar, the Company may appoint a successor Registrar for such purposes.

     (b) Upon due  presentation  for  registration  of  transfer  of any Warrant
Certificate to the Registrar,  the Company shall execute and deliver in the name
of  the  transferee  or  transferees  a  new  Warrant   Certificate  or  Warrant
Certificates in authorized denominations for a like aggregate number of Warrants
bearing   numbers  or  other   distinguishing   symbols  not   contemporaneously
outstanding.

     (c) Any Warrant Certificate or Warrant  Certificates may be exchanged for a
Warrant Certificate or Warrant  Certificates in other authorized  denominations,
representing in the aggregate a like number of Warrants.  A Warrant  Certificate
or  Warrant  Certificates  to  be so  exchanged  shall  be  surrendered  to  the
Registrar,  and the Company shall  execute and deliver in exchange  therefor the
Warrant   Certificate  or  Warrant   Certificates   bearing   numbers  or  other
distinguishing symbols not contemporaneously outstanding.

     (d) The  Company and the  Registrar  may deem and treat the person in whose
name any Warrant  Certificate shall be registered in the Warrant Register as the
absolute  owner of such  Warrant  Certificate  for the  purpose of any  exercise
thereof or any distribution to the Holder thereof and for all other purposes.
     (e) All Warrants  presented for  registration of transfer or exchange shall
(if so  required  by the  Company  or the  Registrar)  be duly  endorsed  by the
registered   Holder  or  Holders   thereof  or  by  the  duly  appointed   legal
representative thereof or by a duly authorized attorney and shall be accompanied
by a written instrument or instruments of transfer or exchange.

     (f) No service charge shall be made for any transfer or exchange of Warrant
Certificates,  but the Company may require  payment  from the  Holder(s) of such
Warrant   Certificates  of  a  sum  sufficient  to  cover  any  stamp  or  other
governmental  charge  or tax that may be  imposed  in  connection  with any such
transfer or exchange.

                  Section II.5. Lost,  Stolen,  Destroyed,  Defaced or Mutilated
Warrant  Certificates.  Upon  receipt by the  Registrar  of evidence  reasonably
satisfactory  to the Company of the loss,  theft,  destruction,  defacement,  or
mutilation  of any  Warrant  Certificate  and,  in the  case  of  mutilation  or
defacement,  upon surrender thereof to the Registrar for cancellation,  then the
Company  shall  execute and  deliver,  in  exchange  for or in lieu of the lost,
stolen,  destroyed,  defaced or  mutilated  Warrant  Certificate,  a new Warrant
Certificate  having the same tenor and for a like number of Warrants,  bearing a
number or other distinguishing  symbol not contemporaneously  outstanding.  Upon
the issuance of any new Warrant  Certificate  pursuant to this Section 2.05, the
Company may require the payment from the Holder of such Warrant Certificate of a
sum sufficient to cover any tax, stamp tax or other governmental charge that may
be imposed in relation  thereto  and may require (if the Holder of such  Warrant
Certificate is the Initial Holder or any of its Affiliates) a written instrument
executed and delivered by the Initial Holder or The Pharmacia & Upjohn  Company,
a Delaware corporation,  undertaking to indemnify and defend the Company against
all claims in  respect  of the lost,  stolen,  destroyed,  defaced or  mutilated
Warrant  Certificate  or (if the Holder is not the Initial  Holder or any of its
Affiliates)  a  lost  instrument  bond  providing  customary   coverage.   Every
substitute Warrant  Certificate  executed and delivered pursuant to this Section
in lieu of any lost, stolen or destroyed Warrant Certificate shall constitute an
additional  contractual  obligation  of the  Company,  whether  or not the lost,
stolen or destroyed  Warrant  Certificate  shall be at any time  enforceable  by
anyone,  and shall be entitled  to the  benefits of (but shall be subject to all
the   limitations   of  rights  set  forth  in)  this   Agreement   equally  and
proportionately  with any and all other Warrant  Certificates  duly executed and
delivered hereunder.


                                   ARTICLE III

                              Exercise of Warrants

                  Section III.1. Duration of Exercise Rights. Each Warrant shall
be exercisable as provided in this Article III from time to time on any Business
Day prior to the Close of Business on the Expiration Date for such Warrant.

                  Section III.2. Right to Purchase. When exercised in accordance
with Section 3.03 or 3.07,  each Warrant  shall  entitle the Holder to purchase,
and the Company  shall be required to issue and  deliver,  a number of shares of
Common  Stock  equal to the Shares  Amount in effect on the day such  Warrant is
exercised in accordance with Section 3.03 or on the Trigger Date, in the case of
an exercise  pursuant to Section 3.07,  at the Exercise  Price for such Warrant;
provided, however, that in the case of an exercise pursuant to Section 3.03, the
Company  may,  at its  sole  election,  pay to the  Holder  of each  Warrant  so
exercised in respect of any one or more of such Warrants cash in an amount equal
to the Cash Amount in lieu of delivering the shares of Common Stock.


                  Section  III.3.  Exercise  Procedures.  In order to exercise a
Warrant,  the Holder must  surrender  the Warrant  Certificate  evidencing  such
Warrant  to the  Registrar,  with  the form of  election  on the  reverse  of or
attached to the Warrant Certificate duly executed,  together with payment of the
Exercise Price.  Any such payment of the Exercise Price shall be by certified or
official bank check or wire transfer to the Company of same day funds.

                  Section  III.4.  Delivery of Shares.  In the event the Company
elects to deliver  the Shares  Amount as  provided  in Section  3.02,  then upon
surrender of the Warrant Certificate in accordance with Section 3.03 the Company
shall  promptly  issue or cause to be issued to or upon the written order of the
Holder of such Warrant Certificate, a certificate or certificates evidencing the
share or shares of  Common  Stock to which  such  Holder is  entitled,  in fully
registered  form,  registered  in such name or names as may be  directed by such
Holder  pursuant  to the form of  election  on the reverse of or attached to the
Warrant Certificate.  Such certificate or certificates  evidencing such share or
shares shall be deemed to have been issued and any persons who are designated to
be named  therein  shall be deemed to have  become  the holder of record of such
share or shares as of the Close of  Business  on the date on which the  Exercise
Price for the related Warrant or Warrants shall have been paid.

                  Section  III.5.  Payment  of Cash.  If the  Company  elects to
deliver the Cash Amount as provided in Section 3.02,  then upon surrender of the
Warrant  Certificate  in accordance  with Section  3.03,  the Company shall make
prompt payment of the Cash Amount in same day funds to the account  specified on
the form of election on the reverse of or attached to the Warrant Certificate.

                  Section III.6.  Certificate for Unexercised Warrants. If fewer
than all the Warrants  represented by a Warrant Certificate are exercised,  such
Warrant  Certificate shall be surrendered to the Registrar with instructions for
the issuance of a new Warrant Certificate and the Company shall promptly execute
and deliver a new Warrant  Certificate  for the Warrants that were not exercised
bearing   numbers  or  other   distinguishing   symbols  not   contemporaneously
outstanding.

                  Section  III.7.  Mandatory  Exercise.  (a) If and  only if the
average  of the  Closing  Prices of the  Common  Stock for the 30  Trading  Days
immediately  preceding  a  particular  date (the  "Trigger  Date")  exceeds  the
Exercise  Price set forth in the Warrant  Certificate  representing  one or more
Warrants,  the Company shall be entitled, at its option exercised within 30 days
following the Trigger Date, to cause the Holder of such Warrant  Certificate  to
exercise  all,  but not fewer than all, of the  related  Warrants  (the  "Called
Warrants") as provided herein.

                  (b) If the Company  elects to cause the Holder to exercise the
Called  Warrants,  it shall  furnish  to the  Holder,  within 30  calendar  days
following  the Trigger  Date, a written  notice  thereof,  (the "Call  Notice"),
specifying  the  identifying  number of the Warrant  Certificate  evidencing the
Called Warrants and the Trigger Date.

                  (c) Not later than three  Business Days following the later of
(i) the date of the Call Notice,  and (ii) the  expiration or termination of any
waiting period (and any extension thereof)  applicable to the acquisition by the
Holder  thereof of the shares of Common  Stock  issuable  upon  exercise  of the
Called Warrants under the Hart-Scott-Rodino  Antitrust Improvements Act of 1976,
as amended and the receipt of all governmental and contractual permits, consents
and approvals  necessary in connection with such acquisition,  the Company shall
deliver to the Holder of the Called  Warrants a certificate  evidencing a number
of shares of Common Stock equal to the product of (x) Shares Amount in effect on
the Trigger Date, multiplied by (y) the number of Called Warrants.

                  (d) Not later than three  Business Days  following the receipt
of the  certificate  referred  to in Section  3.07(c),  the Holder of the Called
Warrants shall deliver to the Company the  certificate  representing  the Called
Warrants and a check for the product of (i) the Exercise  Price,  multiplied  by
(ii) the number of Called Warrants.

                                   ARTICLE IV

                     Compliance With the Securities Act and 
                       Restrictions on Transfer of Shares

                  Section  IV.1.  Acknowledgment.   The  Initial  Holder  hereby
acknowledges  that the  Warrants  and the  shares  of Common  Stock  that may be
received  by the  Initial  Holder  upon  exercise of any Warrant are and will be
subject to certain  restrictions  on transfers  under the Securities Act and the
regulations promulgated thereunder.

     Section IV.2.  Representation.  The Initial Holder hereby represents to the
Company that it is acquiring the Warrants for its own account for investment and
not with a view to the resale or distribution of any interest therein.

                  Section IV.3. Restrictions on Transfer of Shares. Prior to the
thirtieth calendar day following the issuance of shares of Common Stock upon the
exercise  of  Warrants,  the  Initial  Holder  shall  not,  and shall  cause its
Affiliates not to, sell,  assign,  transfer or otherwise dispose of such shares,
except that the Initial Holder may transfer any such shares to any of its wholly
owned  subsidiaries.  The  provisions of this Section 4.03 shall not prohibit or
restrict the sale, assignment, transfer or disposition at any time of any shares
of Common Stock acquired pursuant to Section 3.07.


                                    ARTICLE V

                                   Adjustments

                  Section V.1. Adjustment upon Certain Transactions.  The Shares
Amount (and, by virtue thereof,  the Cash Amount) shall be subject to adjustment
from time to time on and subsequent to the date of this Agreement as follows:

                  (a) In case the Company  shall pay or make a dividend or other
distribution  on its Common  Stock  exclusively  in Common Stock or shall pay or
make a dividend or other  distribution  on any other class or series of stock of
the Company which dividend or  distribution  includes  Common Stock,  the Shares
Amount in effect at the opening of business on the date following the date fixed
for the determination of stockholders entitled to receive such dividend or other
distribution  shall be increased by multiplying such Shares Amount by a fraction
of  which  the  denominator  shall be the  number  of  shares  of  Common  Stock
outstanding  at the Close of Business  on the date fixed for such  determination
and the  numerator  shall be the sum of such  number  of  shares  plus the total
number of shares constituting such dividend or other distribution, such increase
to  become  effective  immediately  after the  opening  of  business  on the day
following  the date  fixed  for such  determination.  For the  purposes  of this
Section  5.01(a),  the number of shares of Common Stock at any time  outstanding
shall not include shares held in the treasury of the Company.  The Company shall
not pay any dividend or make any  distribution on shares of Common Stock held in
the treasury of the Company.

                  (b) In case the Company  shall pay or make a dividend or other
distribution on its Common Stock  consisting  exclusively of, or shall otherwise
issue to all  holders of its Common  Stock,  rights or  warrants  entitling  the
holders  thereof to subscribe for or purchase  shares of Common Stock at a price
per share less than the current  market price per share  (determined as provided
in Section 5.01(g)) of the Common Stock on the date fixed for the  determination
of stockholders  entitled to receive such rights or warrants,  the Shares Amount
in effect at the  opening of business  on the day  following  the date fixed for
such  determination  shall be increased by  multiplying  the Shares  Amount by a
fraction of which the denominator  shall be the number of shares of Common Stock
outstanding  at the Close of Business  on the date fixed for such  determination
plus the number of shares of Common  Stock which the  aggregate  of the offering
price of the total number of shares of Common Stock so offered for  subscription
or purchase would purchase at such current market price and the numerator  shall
be the number of shares of Common Stock  outstanding at the Close of Business on
the date fixed for such  determination plus the number of shares of Common Stock
so offered for  subscription  or  purchase,  such  increase to become  effective
immediately  after the opening of business on the day  following  the date fixed
for such determination.  For the purposes of this Section 5.01(b), the number of
shares of Common Stock at any time outstanding  shall not include shares held in
the treasury of the Company.  The Company shall not issue any rights or warrants
in respect of shares of Common  Stock held in the  treasury of the  Company.  In
case any rights or warrants  referred to in this  Section  5.01(b) in respect of
which an adjustment shall have been made shall expire unexercised within 60 days
after the same shall have been distributed or issued by the Company,  the Shares
Amount shall be readjusted  at the time of such  expiration to the Shares Amount
that would have been in effect if no adjustment  had been made on account of the
distribution or issuance of such expired rights or warrants.

                  (c) In case  outstanding  shares  of  Common  Stock  shall  be
subdivided into a greater number of shares of Common Stock, the Shares Amount in
effect at the opening of business on the day  following  the day upon which such
subdivision   becomes  effective  shall  be   proportionately   increased,   and
conversely,  in case  outstanding  shares of Common Stock shall each be combined
into a smaller number of shares of Common Stock,  the Shares Amount in effect at
the opening of business on the day following the day upon which such combination
becomes  effective  shall  be  proportionately   decreased,  such  reduction  or
increase,  as the case may be, to become effective immediately after the opening
of  business  on the day  following  the day  upon  which  such  subdivision  or
combination  becomes  effective.  No  reduction  in the Shares  Amount may occur
except pursuant to this Section 5.01(c) or the last sentence of Section 5.01(b).

                  (d) Subject to the last two sentences of this Section 5.01(d),
in case the Company shall,  by dividend or otherwise,  distribute to all holders
of its Common Stock evidences of its indebtedness, shares of any class or series
of stock,  cash or assets  (including  securities,  but  excluding any rights or
warrants  referred to in Section  5.01(b),  any  dividend or  distribution  paid
exclusively  in cash and any  dividend  or  distribution  referred to in Section
5.01(a)),  the Shares Amount shall be increased so that the same shall equal the
number  determined by multiplying the Shares Amount in effect  immediately prior
to the effectiveness of the Shares Amount increase  contemplated by this Section
5.01(d) by a fraction of which the numerator  shall be the current  market price
per share (determined as provided in Section 5.01(g)) of the Common Stock on the
date fixed for the payment of such  distribution (the "Reference Date") plus the
fair market value (as  determined  in good faith by the Board of  Directors  and
described in a resolution of the Board of  Directors),  on the Reference Date of
the portion of the evidences of indebtedness,  shares of stock,  cash and assets
so distributed applicable to one share of Common Stock and the denominator shall
be such current  market price per share of the Common  Stock,  such  increase to
become  effective  immediately  prior  to the  opening  of  business  on the day
following the  Reference  Date.  If the Board of Directors  determines  the fair
market  value of any  distribution  for  purposes  of this  Section  5.01(d)  by
reference  to the  actual  or when  issued  trading  market  for any  securities
comprising  such  distribution,  it must in doing so consider the prices in such
market over the same period used in computing the current market price per share
of Common  Stock  pursuant to Section  5.01(g).  For  purposes  of this  Section
5.01(d),  any dividend or  distribution  that includes shares of Common Stock or
rights or warrants to subscribe for or purchase  shares of Common Stock shall be
deemed  instead  to be  (1) a  dividend  or  distribution  of the  evidences  of
indebtedness,  cash,  assets or shares of stock other than such shares of Common
Stock or such rights or warrants (making any Shares Amount increase  required by
this Section 5.01(d))  immediately followed by (2) a dividend or distribution of
such  shares of Common  Stock or such  rights or  warrants  (making  any further
Shares  Amount  increase  required  by  Section  5.01(a)  or (b)  except (A) the
Reference  Date of such  dividend  or  distribution  as defined in this  Section
5.01(d)  shall be  substituted  as "the  date  fixed  for the  determination  of
stockholders entitled to receive such dividend or other distribution", "the date
fixed for the  determination of stockholders  entitled to receive such rights or
warrants"  and "the date fixed for such  determination"  within  the  meaning of
Section  5.01(a)  or (b) and (B) any  shares of Common  Stock  included  in such
dividend  or  distribution  shall  not be  deemed  "outstanding  at the Close of
Business on the date fixed for such determination" within the meaning of Section
5.01(a) or (b)).

                  (e) In case the Company  shall pay or make a dividend or other
distribution on the Common Stock  exclusively in cash the Shares Amount shall be
increased so that the same shall equal the number  determined by multiplying the
Shares Amount in effect  immediately  prior to the  effectiveness  of the Shares
Amount increase  contemplated by this Section 5.01(e) by a fraction of which the
numerator shall be the current market price per share (determined as provided in
Section  5.01(g)) of the Common  Stock on the date fixed for the payment of such
distribution  plus the amount of cash so distributed  applicable to one share of
Common Stock and the denominator shall be such current market price per share of
Common Stock, such increase to become effective immediately prior to the opening
of  business  on the day  following  the  date  fixed  for the  payment  of such
distribution.

                  (f) In case a tender or exchange  offer made by the Company or
by any  subsidiary  of the Company  for all or any  portion of the Common  Stock
shall expire and such tender or exchange  offer shall involve the payment by the
Company or such subsidiary of  consideration  per share of Common Stock having a
fair market value (as  determined  in good faith by the Board of  Directors  and
described  in a  resolution  of the  Board of  Directors)  at the last time (the
"Expiration Time") shares of Common Stock may be tendered into to such tender or
exchange  offer (as it shall have been amended) that exceeds the current  market
price per share  (determined as provided in Section 5.01(g)) of the Common Stock
on the Trading Day next succeeding the Expiration  Time, the Shares Amount shall
be increased so that the same shall equal the number  determined by  multiplying
the Shares Amount in effect immediately prior to the effectiveness of the Shares
Amount increase  contemplated by this Section 5.01(f) by a fraction of which the
denominator shall be the number of shares of Common Stock outstanding (including
any tendered or  exchanged  shares) at the  Expiration  Time  multiplied  by the
current market price per share  (determined  as provided in Section  5.01(g)) of
the Common Stock on the Trading Day next  succeeding the Expiration Time and the
numerator  shall  be  the  sum of (x)  the  fair  market  value  (determined  as
aforesaid) of the aggregate  consideration  payable to stockholders based on the
acceptance  (up to any maximum  specified in the terms of the tender or exchange
offer) of all shares  validly  tendered or exchanged and not withdrawn as of the
Expiration  Time (the shares deemed so accepted,  up to any such maximum,  being
referred  to as the  "Purchased  Shares")  and (y) the  product of the number of
shares of Common Stock outstanding (less any Purchased Shares) at the Expiration
Time and the current  market price per share  (determined as provided in Section
5.01(g)) of the Common Stock on the Trading Day next  succeeding  the Expiration
Time,  such  increase to become  effective  immediately  prior to the opening of
business on the day following the Expiration Time.

                  (g) For the purpose of any computation  under Section 5.01(b),
(d), (e) and (f), the  "current  market  price" per share of Common Stock on any
date in question  shall be deemed to be the average of the daily Closing  Prices
for the  five  consecutive  Trading  Days  prior  to and  including  the date in
question;  provided, however, that (1) if the "ex" date (as hereinafter defined)
for  any  event  (other  than  the  issuance  or  distribution   requiring  such
computation)  that  requires  an  adjustment  to the Shares  Amount  pursuant to
Section 5.01(a), (b), (c), (d), (e), (f) or (h) ("Other Event") occurs after the
fifth  Trading Day prior to the day in  question  and prior to the "ex" date for
the issuance or distribution  requiring such computation (the "Current  Event"),
the  Closing  Price for each  Trading  Day prior to the "ex" date for such Other
Event shall be adjusted by  multiplying  such Closing Price by the reciprocal of
the  fraction  by which the Shares  Amount is so  required  to be  adjusted as a
result of such  Other  Event,  (2) if the "ex" date for any Other  Event  occurs
after  the  "ex"  date  for the  Current  Event  and on or  prior to the date in
question,  the Closing Price for each Trading Day on and after the "ex" date for
such Other  Event shall be adjusted by  multiplying  such  Closing  Price by the
fraction by which the Shares Amount is so required to be adjusted as a result of
such Other  Event,  (3) if the "ex" date of any Other  Event  occurs on the "ex"
date for the Current Event,  one of those events shall be deemed for purposes of
clauses (1) and (2) of this proviso to have an "ex" date occurring  prior to the
"ex" date for the other event, and (4) if the "ex" date for the Current Event is
on or prior to the date in question,  after  taking into account any  adjustment
required  pursuant to clause (2) of this  proviso,  the  Closing  Price for each
Trading Day on or after such "ex" date shall be  adjusted by adding  thereto the
amount  of any cash  and the fair  market  value  on the  date in  question  (as
determined in good faith by the Board of Directors in a manner  consistent  with
any  determination  of such value for  purposes of Section  5.01(d) or (e),  and
described  in a  resolution  of the Board of  Directors)  of the  portion of the
rights,  warrants,  evidences of  indebtedness,  shares of stock or assets being
distributed  applicable  to one share of Common  Stock.  For the  purpose of any
computation under Section 5.01(f),  the current market price per share of Common
Stock on any date in  question  shall be deemed to be the  average  of the daily
Closing  Prices for such date in question  and the next two  succeeding  Trading
Days;  provided,  however,  that if the "ex" date for any event  (other than the
tender or exchange offer requiring such computation) that requires an adjustment
to the Shares Amount pursuant to Section 5.01(a), (b), (c), (d), (e), (f) or (h)
occurs after the Expiration Time for the tender or exchange offer requiring such
computation  and on or prior to the second  Trading  Day  following  the date in
question,  the Closing Price for each Trading Day on and after the "ex" date for
such other  event shall be adjusted by  multiplying  such  Closing  Price by the
fraction by which the Shares Amount is so required to be adjusted as a result of
such other event.  For purposes of this paragraph,  the term "ex" date, (1) when
used with respect to any issuance or distribution, means the first date on which
the Common Stock trades regular way on the relevant  exchange or in the relevant
market from which the Closing  Price was  obtained  without the right to receive
such issuance or distribution,  (2) when used with respect to any subdivision or
combination of shares of Common Stock,  means the first date on which the Common
Stock  trades  regular way on such  exchange or in such market after the time at
which such subdivision or combination becomes effective,  and (3) when used with
respect  to any  tender or  exchange  offer,  means the first  date on which the
Common  Stock  trades  regular way on such  exchange or in such market after the
Expiration Time of such offer.

                  (h) The Company may make such  increase in the Shares  Amount,
in addition to those required by Section 5.01(a),  (b), (c), (d), (e) and (f) as
it  considers  to be  advisable to avoid or diminish an income tax to holders of
Common Stock or rights to purchase  Common Stock  resulting from any dividend or
distribution  of stock (or rights to acquire stock) or from any event treated as
such for income tax  purposes.  The Company  from time to time may  increase the
Shares  Amount by any  amount  for any  period of time if the period is at least
twenty days,  the increase is  irrevocable  during the period,  and the Board of
Directors  shall have made a  determination  that such increase  would be in the
best interest of the Company.  Whenever the Shares Amount is increased  pursuant
to the  preceding  sentence,  the Company  shall mail to Holders a notice of the
increase at least  fifteen days prior to the date the  increased  Shares  Amount
takes effect,  and such notice shall state the  increased  Shares Amount and the
period it will be in effect.

                  (i) No  adjustment  in the  Shares  Amount  shall be  required
unless such  adjustment  would require an increase or decrease of at least 1% in
the Shares Amount;  provided,  however,  that any adjustments which by reason of
this Section  5.01(i) are not  required to be made shall be carried  forward and
taken into account in any subsequent adjustment.

                  (j) Whenever the Shares Amount is adjusted as herein provided,
the  Company  shall  compute  the  adjusted  Shares  Amount and shall  prepare a
certificate  signed by the Chief Financial  Officer of the Company setting forth
the adjusted Shares Amount and showing in reasonable detail the facts upon which
such  adjustment is based,  and a copy of such  certificate  shall  forthwith be
delivered to each Holder.

                  Section V.2. No Fractional  Shares.  No  fractional  shares of
Common  Stock shall be issued upon  exercise of the  Warrants.  If more than one
Warrant is exercised  by the same Holder at one time,  the number of full shares
issuable  upon such  exercise  shall be computed  on the basis of the  aggregate
number of Warrants so exercised. Instead of any fractional share of Common Stock
that would otherwise be issuable to a holder upon exercise of the Warrants,  the
Company shall pay a cash  adjustment in respect of such  fractional  share in an
amount equal to the same fraction of the Closing Price per share of Common Stock
as of the date of such exercise.

                  Section V.3. Reclassification,  Consolidation,  Merger or Sale
of Assets.  In the event that the  Company  shall be a party to any  transaction
(including without limitation any  recapitalization  or  reclassification of the
Common  Stock  (other  than a change in par  value,  or from par value to no par
value,  or from no par value to par value,  or as a result of a  subdivision  or
combination of the Common Stock and other than the  reclassification of unissued
Common Stock into other stock of the Company),  any consolidation of the Company
with,  or merger of the Company into,  any other  Person,  any merger of another
person  into the  Company  (other  than a merger  which  does  not  result  in a
reclassification,  conversion, exchange or cancellation of outstanding shares of
Common Stock of the Company),  any sale or transfer of all or substantially  all
of the assets of the Company or any compulsory share exchange) pursuant to which
the Common Stock is converted into the right to receive other  securities,  cash
or other property,  then lawful provisions shall be made as part of the terms of
such transaction  whereby the holder of each Warrant then outstanding shall have
the right  thereafter  to exercise  such Warrant only for (i) in the case of any
such  transaction  other than a Common Stock  Fundamental  Change (as defined in
Section  5.06(b)) and subject to funds being legally  available for such purpose
under  applicable  law at the time of such  exercise,  the kind  and  amount  of
securities, cash and other property receivable upon such transaction by a holder
of the number of shares of Common  Stock of the Company  for which such  Warrant
could have been exercised immediately prior to such transaction, and (ii) in the
case of a Common Stock Fundamental Change,  common stock of the kind received by
holders of Common Stock as a result of such Common Stock  Fundamental  Change in
an amount determined  pursuant to the provisions of Section 5.05. The Company or
the Person formed by such  consolidation  or resulting from such merger or which
acquires such assets or which acquires the Company's shares, as the case may be,
shall  execute an agreement in form and substance  reasonably  acceptable to the
Holders  evidencing  such right.  Such agreement  shall provide for  adjustments
which, for events  subsequent to the effective date of such agreement,  shall be
as nearly  equivalent as may be practicable to the  adjustments  provided for in
this Article VI. The above  provisions  shall  similarly apply to each and every
successive transaction of the foregoing type.

                  Section V.4.  Prior Notice of Certain Events.  In case:

               (a) the  Company  shall (i) declare  any  dividend  (or any other
          distribution)  on its Common Stock,  other than (A) a dividend payable
          in shares  of Common  Stock or (B) a  dividend  payable  in cash in an
          amount not greater than its retained  earnings  other than any special
          or  nonrecurring  or other  extraordinary  dividend or (ii) declare or
          authorize  a  redemption  or  repurchase  of in  excess  of 10% of the
          then-outstanding shares of Common Stock; or

               (b) the Company  shall  authorize  the granting to all holders of
          Common  Stock of rights or warrants to  subscribe  for or purchase any
          share of stock  of any  class or  series  or of any  other  rights  or
          warrants; or

               (c)  of  any  reclassification  of  Common  Stock  (other  than a
          subdivision  or  combination  of the  outstanding  Common Stock,  or a
          change in par value, or from par value to no par value, or from no par
          value to par value and other  than the  reclassification  of  unissued
          Common Stock into other stock of the Company), or of any consolidation
          or merger to which the  Company is a party and for which  approval  of
          any  shareholders of the Company shall be required,  or of the sale or
          transfer of all or  substantially  all of the assets of the Company or
          of any compulsory share exchange whereby the Common Stock is converted
          into other securities, cash or other property; or

               (d) of the voluntary or involuntary  dissolution,  liquidation or
          winding up of the Company;

then the Company  shall cause to be delivered  to the Holders,  at least 10 days
prior to the applicable record or effective date hereinafter specified, a notice
stating  (x) the date on which a record (if any) is to be taken for the  purpose
of such dividend, distribution,  redemption,  repurchase, rights or warrants or,
if a record is not to be taken, the date as of which the holders of Common Stock
of record to be entitled to such dividend,  distribution,  redemption, rights or
warrants are to be  determined  or (y) the date on which such  reclassification,
consolidation,  merger, sale, transfer, share exchange, dissolution, liquidation
or winding up is  expected to become  effective,  and the date as of which it is
expected  that  holders of Common  Stock of record shall be entitled to exchange
their shares of Common Stock for securities,  cash or other property deliverable
upon  such  reclassification,   consolidation,  merger,  sale,  transfer,  share
exchange,  dissolution,  liquidation  or winding up (but no failure to mail such
notice or any defect therein or in the mailing thereof shall affect the validity
of the corporate action required to be specified in such notice).

                  Section V.5.  Adjustments in Case of Fundamental  Changes. (a)
Notwithstanding  any other  provision in this Article 6 to the contrary,  if any
Fundamental  Change  (as  defined in Section  5.06(c))  occurs,  then the Shares
Amount in effect will be adjusted  immediately after such Fundamental  Change as
described  in  Section  5.05(c).  In  addition,  in the event of a Common  Stock
Fundamental  Change (as  defined  in Section  5.06(b)),  each  Warrant  shall be
exercisable  solely in exchange for common stock of the kind and amount received
by holders of Common Stock as a result of such Common Stock  Fundamental  Change
as more specifically provided in Section 5.05(b).

                  (b) For  purposes of  calculating  any  adjustment  to be made
pursuant to this Section 5.05 in the event of a Fundamental Change,  immediately
after such Fundamental Change in the case of a Common Stock Fundamental  Change,
the Shares Amount in effect  immediately  prior to such Common Stock Fundamental
Change, but after giving effect to any other prior adjustments effected pursuant
to this Article V, shall thereupon be adjusted by multiplying such Shares Amount
by a fraction of which the  denominator  shall be the Purchaser  Stock Price (as
defined in Section  5.06(e)) and the numerator shall be the Applicable Price (as
defined in Section 5.06(a));  provided,  however,  that in the event of a Common
Stock  Fundamental  Change  in which  (A)  100% by  value  of the  consideration
received by a holder of Common Stock is common stock of the successor,  acquiror
or other third party (and cash,  if any, is paid with respect to any  fractional
interests in such common  stock  resulting  from such Common  Stock  Fundamental
Change) and (B) all of the Common Stock shall have been exchanged for, converted
into or  acquired  for  common  stock  (and  cash  with  respect  to  fractional
interests) of the successor, acquiror or other third party, the Shares Amount in
effect immediately prior to such Common Stock Fundamental Change shall thereupon
be adjusted by multiplying  such Shares Amount by the number of shares of common
stock of the successor, acquiror, or other third party received by a shareholder
for one  share of  Common  Stock as a result of such  Common  Stock  Fundamental
Change.

     Section V.6.  Definitions.  The following  definitions shall apply to terms
used in this Article V:

                  (a)  "Applicable  Price" means (1) in the event of a Non-Stock
Fundamental  Change in which the holders of the Common Stock  receive only cash,
the amount of cash received by a  shareholder  for one share of Common Stock and
(2) in the event of any other Non-Stock  Fundamental  Change or any Common Stock
Fundamental  Change, the average of the daily Closing Prices of the Common Stock
for the ten consecutive  Trading Days prior to and including the record date for
the determination of the holders of Common Stock entitled to receive securities,
cash or other property in connection with such Non-Stock  Fundamental  Change or
Common Stock Fundamental  Change,  or, if there is no such record date, the date
upon which the holders of the Common  Stock shall have the right to receive such
securities,  cash or other property,  in each case, as adjusted in good faith by
the Board of Directors of the Company to appropriately reflect any of the events
referred to in Section 5.01(a), (b), (c), (d), (e), (f) and (h).

                  (b) "Common Stock  Fundamental  Change" means any  Fundamental
Change in which more than 50% by value (as determined in good faith by the Board
of Directors) of the consideration  received by holders of Common Stock consists
of common stock that for each of the ten  consecutive  Trading Days  referred to
with  respect  to such  Fundamental  Change in  Section  5.05(i)  above has been
admitted for listing or admitted for listing  subject to notice of issuance on a
national  securities  exchange or quoted on the NASDAQ  National  Market System;
provided,  however,  that a  Fundamental  Change  shall  not be a  Common  Stock
Fundamental  Change unless  either (1) the Company  continues to exist after the
occurrence of such Fundamental  Change and the outstanding  Warrants continue to
exist as  outstanding  Warrants,  or (2) not later than the  occurrence  of such
Fundamental Change, the outstanding Warrants are converted into or exchanged for
warrants of a  corporation  succeeding  to the  business of the  Company,  which
warrants have terms identical to those of the Warrants.


           (c)   "Fundamental   Change"  means  the   occurrence  of  any
transaction  or  event  in  connection  with a plan  pursuant  to  which  all or
substantially  all of the Common Stock shall be exchanged for,  converted  into,
acquired for or constitute solely the right to receive securities, cash or other
property  (whether by means of an exchange  offer,  liquidation,  tender  offer,
consolidation,  merger,  combination,   reclassification,   recapitalization  or
otherwise);  provided,  however,  in the case of a plan  involving more than one
such transaction or event, for purposes of adjustment of the Shares Amount, such
Fundamental  Change shall be deemed to have occurred when  substantially  all of
the Common  Stock of the Company  shall be exchanged  for,  converted  into,  or
acquired  for or  constitute  solely  the  right to  receive  cash,  securities,
property or other  assets,  but the  adjustment  shall be based upon the highest
weighted average of consideration per share which a holder of Common Stock could
have received in such  transactions or events as a result of which more than 50%
of the Common Stock shall have been exchanged for,  converted  into, or acquired
for or  constitute  solely the rights to receive cash,  securities,  property or
other assets.

                  (d)  "Non-Stock  Fundamental  Change"  means  any  Fundamental
Change other than a Common Stock Fundamental Change.

                  (e) "Purchaser Stock Price" means,  with respect to any Common
Stock Fundamental  Change, the average of the daily Closing Prices of the common
stock received in such Common Stock  Fundamental  Change for the ten consecutive
Trading Days prior to and including the record date for the determination of the
holders of Common Stock  entitled to receive such common stock,  or, if there is
no such record  date,  the date upon which the holders of the Common Stock shall
have the right to receive such common  stock,  in each case, as adjusted in good
faith by the Board of  Directors  to  appropriately  reflect  any of the  events
referred to in Section  5.01(a),  (b),  (c),  (d),  (e), (f) and (h);  provided,
however,  if no such  Closing  Prices of the common  stock for such Trading Days
exist, then the Purchaser Stock price shall be set at a price determined in good
faith by the Board of Directors.

                  Section V.7. Certain  Additional  Rights.  In case the Company
shall,  by dividend or otherwise,  declare or make a distribution  on the Common
Stock referred to in Section 5.01(d) or 5.01(e) (including,  without limitation,
dividends  or  distributions  referred to in the last two  sentences  of Section
5.01(d)),  the holder of each Warrant,  upon the exercise thereof  subsequent to
the Close of Business on the date fixed for the  determination  of  shareholders
entitled to receive  such  distribution  and prior to the  effectiveness  of the
Shares Amount adjustment in respect of such distribution, shall also be entitled
to receive for each share of Common Stock for which such  Warrant is  exercised,
the  portion of the  shares of Common  Stock,  rights,  warrants,  evidences  of
indebtedness,  shares of stock, cash and assets so distributed applicable to one
share of Common Stock;  provided,  however, that, at the election of the Company
(whose  election  shall be evidenced by a resolution  of the Board of Directors)
with  respect  to all  holders  so  exercising,  the  Company  may,  in  lieu of
distributing to such holder any portion of such  distribution  not consisting of
cash or  securities  of the Company,  pay such holder an amount in cash equal to
the fair  market  value  thereof  (as  determined  in good faith by the Board of
Directors  and  described in a  resolution  of the Board of  Directors).  If any
exercise of a Warrant  described in the  immediately  preceding  sentence occurs
prior to the payment  date for a  distribution  to holders of Common Stock which
the holder of the Warrant so exercised is entitled to receive in accordance with
the immediately  preceding sentence,  the Company may elect (such election to be
evidenced by a  resolution  of the Board of  Directors)  to  distribute  to such
holder a due bill for the shares of Common Stock, rights, warrants, evidences of
indebtedness,  shares  of  stock,  cash or  assets  to which  such  holder is so
entitled,  provided that such due bill (i) meets any applicable  requirements of
the principal national  securities  exchange or other market on which the Common
Stock is then  traded and (ii)  requires  payment or  delivery of such shares of
Common Stock, rights, warrants, evidences of indebtedness, shares of stock, cash
or assets no later than the date of payment  or  delivery  thereof to holders of
shares of Common Stock receiving such distribution.

                  Section V.8. Reservation of Shares, etc. (a) The Company shall
at all times reserve and keep available,  free from preemptive rights out of its
authorized and unissued  stock,  solely for the purpose of allowing the exercise
of the Warrants, such number of shares of its Common Stock as shall from time to
time be  sufficient  to permit the Company to deliver  the Shares  Amount in the
event all of the Warrants  from time to time  outstanding  were  exercised.  The
Company  shall from time to time,  in  accordance  with the laws of the State of
Delaware,  increase  the  authorized  number of shares of Common Stock if at any
time the number of shares of authorized  and unissued  Common Stock shall not be
sufficient  to permit the Company to deliver the Shares Amount upon the exercise
of all of the then-outstanding  Warrants (taking into account the adjustments to
the Shares Amount that are provided for herein).

     (b) If any shares of Common Stock  required to be reserved for
purposes of the exercise of the Warrants hereunder require  registration with or
approval  of any  governmental  authority  under any Federal or State law before
such shares may be issued upon exercise,  and an exemption under Section 3(a)(9)
of the Securities Act or similar exemption is not available, the Company will in
good faith and as expeditiously as possible  endeavor to cause such shares to be
duly registered or approved as the case may be. If the Common Stock is quoted on
the NASDAQ  National  Market  System or listed on any U.S.  national  securities
exchange, the Company will, if permitted by the rules of such exchange, list and
keep listed on such exchange,  upon official  notice of issuance,  all shares of
Common Stock issuable upon exercise of the Warrants. The second sentence of this
paragraph   shall  apply  only  when  the  Warrants  shall  have  become  freely
transferable  pursuant to Rule 144(k) under the  Securities Act or if the shares
of Common  Stock  issuable  upon  exercise of the  Warrants  are exempt from the
registration  requirements  of the  Securities  Act by operation of an exemption
referred to in the first sentence of this paragraph.

                  Section V.9. Dividend or Interest  Reinvestment Plans or Other
Plans.  Notwithstanding the foregoing provisions,  the issuance of any shares of
Common Stock pursuant to any plan providing for the reinvestment of dividends or
interest  payable on securities of the Company and the  investment of additional
optional amounts in shares of Common Stock under any such plan (i.e., a "DRIP"),
and the  issuance of any shares of Common Stock or options or rights to purchase
such shares pursuant to any employee or director  benefit plan or program of the
Company or pursuant to any option,  warrant, right or exercisable,  exchangeable
or convertible security outstanding as of the date hereof shall not be deemed to
constitute  an  issuance  of  Common  Stock  or  exercisable,   exchangeable  or
convertible  securities by the Company to which any of the adjustment provisions
described above applies. In addition, no adjustment to the Shares Amount or Cash
Amount  pursuant to this  Article V shall be made in respect of any  transaction
expressly  permitted by Section  7.02(h)(iii)  of the Credit  Agreement.  If any
action would require  adjustment of the Shares Amount  pursuant to more than one
of the provisions  described in this Article V only one adjustment shall be made
and such  adjustment  shall be the amount of  adjustment  which has the  highest
absolute value to holders of the Warrants.


                                   ARTICLE VI

                         Representations and Warranties

                  The Company hereby represents and warrants,  as of the date of
this Agreement, as follows:

     Section VI.1. Good Standing and Power.  The Company is a corporation,  duly
incorporated  and  validly  existing  in good  standing  under  the  laws of the
jurisdiction of its incorporation.

                  Section  VI.2.  Corporate  Authority.  The  Company  has  full
corporate  power and authority to execute and deliver,  and to incur and perform
its obligations under, this Agreement and each Warrant Certificate, all of which
have been duly  authorized and will have been duly  authorized by all proper and
necessary  corporate  action. No consent or approval of stockholders is required
or will be required as a condition  to the  validity or  performance  of, or the
exercise by any Holder of any of its rights or remedies under, this Agreement or
any Warrant Certificate.

                  Section VI.3.  Authorizations.  All authorizations,  consents,
approvals,  registrations,  notices,  exemptions  and licenses  with or from any
Governmental Authority or other Person necessary for the execution, delivery and
performance by the Company of, and the incurrence and performance of each of its
obligations under, this Agreement and each Warrant Certificate, and the exercise
by any Holder of its remedies  under this  Agreement or any Warrant  Certificate
have been effected or obtained and are and will be in full force and effect.

                  Section VI.4. Binding Obligation.  This Agreement  constitutes
and, when issued in accordance with the terms hereof,  each Warrant  Certificate
will  constitute,  a  valid  and  legally  binding  obligation  of  the  Company
enforceable  in  accordance  with  its  terms,  subject  as  to  enforcement  to
bankruptcy, insolvency,  reorganization,  moratorium and similar laws of general
applicability  relating to or affecting  creditors' rights and to general equity
principles.

     Section VI.5. No Conflicts.  There is no statute,  regulation,
rule, order or judgment, and no provision of any agreement or instrument binding
upon the Company or any of its subsidiaries,  or affecting their properties, and
no provision of the certificate of incorporation or bylaws of the Company or any
of its subsidiaries, that would prohibit, conflict with or in any way impair the
execution or delivery of, or the incurrence or performance of any obligations of
the Company under,  this Agreement or any Warrant  Certificate,  or result in or
require the creation or imposition  of any lien,  charge or  encumbrance  of any
type on property of the Company or any of its  subsidiaries  as a consequence of
the  execution,  delivery  and  performance  of this  Agreement  or any  Warrant
Certificate.

     Section VI.6.  Reservation.  The Board of Directors has unanimously adopted
the resolutions set forth in Exhibit B.

                                   ARTICLE VII

                                    Covenants

                  Section  VII.1.  Reservation  of Common  Stock for Issuance on
Exercise of Warrants.  The Company  covenants  that it will at all times reserve
and keep  available,  free from  preemptive  rights,  out of its  authorized but
unissued  shares of Common Stock,  solely for the purpose of issue upon exercise
of Warrants, as herein provided,  such number of shares of Common Stock as shall
then be  issuable  upon the  exercise  of all  Warrants  issued  hereunder.  The
transfer agent for the Common Stock (the  "Transfer  Agent") will be irrevocably
authorized and directed at all times to reserve such number of authorized shares
as shall be required  for such  purpose.  The  Company  will keep a copy of this
Agreement  on file  with  the  Transfer  Agent.  The  Warrant  Agent  is  hereby
irrevocably authorized to requisition from time to time from such Transfer Agent
the stock  certificates  required to honor  outstanding  Warrants  upon exercise
thereof in accordance with the terms of this Agreement.  The Company represents,
warrants and covenants that, upon payment  therefor,  all shares of Common Stock
issued upon the exercise of warrants shall be duly  authorized,  validly issued,
fully paid and nonassessable, free of preemptive rights and free from all taxes,
liens, charges and security interests with respect to the issuance thereof.

     Section  VII.2.  Notice of Dividends.  At any time when and if
the Company  declares any dividend on Common Stock,  it shall give notice to the
Holders of all the then  outstanding  Warrants of any such declaration not fewer
than 10 days prior to the related  record  date for  payment of the  dividend so
declared.

                  Section  VII.3.  Reports.  For so long as any Warrants  remain
outstanding  and not expired by their terms,  the Company  shall  furnish to the
Holders the  information  required to be delivered  pursuant to Rule  144A(d)(4)
under the Securities Act. In addition,  the Company shall furnish to the Initial
Holder within ten days after it files them with the Commission copies of its SEC
Reports. In the event the Company shall cease to be required to file SEC Reports
pursuant to the  Exchange  Act,  the Company  shall  nevertheless  mail such SEC
Reports to Holders upon their request.


                                  ARTICLE VIII

                                     Holders

                  Section VIII.1. Holder Not Deemed a Shareholder. No Holder, as
such, shall be entitled to vote,  receive dividends or be deemed for any purpose
the holder of Common Stock or any other  securities  of the Company which may at
any time be issuable on the exercise or conversion  of the Warrants  represented
thereby,  nor shall anything  contained herein or in any Warrant  Certificate be
construed to confer upon a Holder,  as such,  any of the rights of a stockholder
of the Company or any right to vote for the  election of  directors  or upon any
matter submitted to shareholders at any meeting thereof,  or to give or withhold
consent to any  corporate  action,  or to receive  notice of  meetings  or other
actions affecting  stockholders (except as specifically  provided herein), or to
receive dividends or subscriptions  rights,  or otherwise,  until the Warrant or
Warrants evidenced by such Warrant Certificate shall have been exercised and the
Company  shall have  elected to  deliver  Common  Stock (and not cash) upon such
exercise.

                  Section  VIII.2.  Right of  Action.  All  rights  of action in
respect  of this  Agreement  are  vested in the  Holders,  and any Holder of any
Warrant,  without  consent of any other Holder,  may on such Holder's own behalf
and for such Holder's own benefit,  enforce,  and may institute and maintain any
suit, action or proceeding against the Company suitable to enforce, or otherwise
in respect  of, such  Holder's  right to  exercise  or  exchange  such  Holder's
Warrants in the manner provided in this Agreement.

                                   ARTICLE IX

                                  Miscellaneous

                  Section  IX.1.  Payment of Taxes.  The  Company  shall pay all
transfer,  stamp and other  similar  taxes that may be imposed in respect of the
issuance or delivery of  Warrants,  or in respect of the issuance or delivery of
any securities  upon exercise of Warrants,  and any and all filing fees incurred
by a Holder in connection with the matters described in Section 3.07(c)(ii). The
Company shall not be required,  however,  to pay any tax or other charge imposed
in connection  with any transfer  involved in the issue of any  certificate  for
shares of Common Stock or other securities underlying the Warrants or payment of
cash to any Person  other than the Holder of a Warrant  Certificate  surrendered
upon the  exercise  or purchase  of a Warrant,  and in case of such  transfer or
payment, the Company shall not be required to issue any stock certificate or pay
any cash until such tax or charge  has been paid or it has been  established  to
the Company's reasonable satisfaction that no such tax or other charge is due.

                  Section IX.2. Expenses;  Indemnity.  (a) The Company agrees to
pay or  reimburse  the  Initial  Holder for all  reasonable  costs and  expenses
incurred in connection  with the enforcement or preservation of any rights under
this  Agreement,  any  Warrant,  any  Warrant  Certificate,  and any such  other
documents,  including, without limitation, the reasonable fees and disbursements
of counsel to the Initial Holder (but excluding fees and disbursements  incurred
on or prior to the date hereof in  negotiating  and preparing this Agreement and
the related documents);  provided,  however, that in the event of any litigation
between  the  Company  and any  Holder  initiated  prior to any Event of Default
specified in Section  8.01(g) or (h) of the Credit  Agreement and arising out of
the  matters  set forth in Section  9.04(b)(i),  the fees and  disbursements  of
counsel to the Initial  Holder  shall be borne by the Company if and only if the
Initial Holder is the prevailing party.


                  (b) The Company agrees to indemnify the Initial Holder and its
directors,  officers,  employees,  agents and Affiliates (each, an "Indemnitee")
against,  and to hold  each  Indemnitee  harmless  from,  any  and  all  claims,
liabilities,  damages,  losses,  costs, charges and expenses (including fees and
expenses of counsel) incurred by or asserted against any Indemnitee  arising out
of, in any way  connected  with, or as a result of (i) the execution or delivery
of this Agreement or any agreement or instrument contemplated by this Agreement,
the performance by the parties hereto of their respective obligations under this
Agreement,  any Warrant or any Warrant  Certificate or the  consummation  of the
transactions and the other transactions contemplated hereby or thereby, (ii) the
use of the proceeds of the exercise of Warrants or (iii) any claim,  litigation,
investigation or proceeding relating to any of the foregoing, whether or not any
Indemnitee is a party thereto.  The provisions of this Section 9.04(b) shall not
operate or be construed  to indemnify  the Initial  Holder  against,  or hold it
harmless from, any claims,  liabilities,  damages,  losses,  costs,  charges and
expenses  (including  fees and  expenses  of  counsel)  incurred  by or asserted
against  the Initial  Holder  arising out of or  connected  with any  litigation
initiated  prior to any Event of Default  specified  in  Section  8.01(g) or (h)
solely between the Company and the Initial Holder in which the Initial Holder is
not the prevailing party.

     (c) All amounts due under this Section 9.02 shall be payable in immediately
available funds upon written demand therefor.

                  Section IX.3.  APPLICABLE  LAW. THIS  AGREEMENT,  EACH WARRANT
CERTIFICATE,  EACH WARRANT  ISSUED  HEREUNDER AND ALL RIGHTS  ARISING  HEREUNDER
SHALL BE GOVERNED BY AND CONSTRUED IN  ACCORDANCE  WITH THE LAWS OF THE STATE OF
NEW YORK  APPLICABLE TO CONTRACTS MADE AND TO BE PERFORMED  ENTIRELY WITHIN SUCH
STATE.

                  SECTION  IX.4.  WAIVER OF JURY.  THE  COMPANY  AND THE INITIAL
HOLDER EACH HEREBY  WAIVES TRIAL BY JURY IN ANY JUDICIAL  PROCEEDING  INVOLVING,
DIRECTLY  OR  INDIRECTLY,  ANY MATTER  (WHETHER  SOUNDING  IN TORT,  CONTRACT OR
OTHERWISE)  IN ANY WAY  ARISING  OUT OF,  RELATED  TO,  OR  CONNECTED  WITH THIS
AGREEMENT,  ANY WARRANT CERTIFICATE,  ANY WARRANT ISSUED HEREUNDER AND ANY RIGHT
ARISING HEREUNDER.


                  Section IX.5.  Jurisdiction and Venue; Service of Process. (a)
The  Company  and the Initial  Holder  each  hereby  irrevocably  submits to the
non-exclusive  jurisdiction  of any state or  federal  court in the  Borough  of
Manhattan, The City of New York for the purpose of any suit, action,  proceeding
or  judgment  relating  to  or  arising  out  of  this  Agreement,  any  Warrant
Certificate,  any Warrant issued hereunder and any right arising hereunder,  and
to the laying of venue in the Borough of  Manhattan,  The City of New York.  The
Company and the Initial Holder each hereby  irrevocably  waives,  to the fullest
extent  permitted by applicable law, any objection to the laying of the venue of
any such suit,  action or proceeding  brought in the aforesaid courts and hereby
irrevocably waives any claim that any such suit, action or proceeding brought in
any such court has been brought in an inconvenient forum.

                  (b) The  Company  agrees  that  service of process in any such
action or proceeding  may be effected by mailing a copy thereof by registered or
certified mail (or any substantially  similar form of mail), postage prepaid, to
the Company at its address set forth in Section 9.08 or at such other address of
which the Initial Holder shall have been notified pursuant thereto.  The Company
further  agrees that nothing  herein shall affect the right to effect service of
process in any other manner permitted by law or shall limit the right to sue any
other jurisdiction.

                  (c) Each of the Initial Holder and the Company waives,  to the
maximum  extent not prohibited by law, any right it may have to claim or recover
in any legal action or proceeding  referred to in this Section 9.05 any special,
exemplary, punitive or consequential damages.

     Section IX.6.  Amendments and Waivers.  (a) Any provision of this Agreement
may be  amended,  modified,  supplemented  or  waived,  but  only  by a  written
amendment  or  supplement,  or written  waiver,  signed by the  Company  and the
Initial Holder.

                  (b)  Except to the extent  expressly  set forth  therein,  any
waiver  shall be effective  only in the  specific  instance and for the specific
purpose for which such waiver is given.

                  Section IX.7.  Cumulative  Rights;  No Waiver.  Each and every
right  granted to any Holder  hereunder  or under any  Warrant  Certificate,  or
allowed such Holder by law or equity,  shall be cumulative and not exclusive and
may be  exercised  from time to time.  No  failure  on the part of any Holder to
exercise,  and no  delay in  exercising,  any  right  will  operate  as a waiver
thereof,  nor will any  single or  partial  exercise  by any Holder of any right
preclude  any other or future  exercise  thereof  or the  exercise  of any other
right.


                  Section IX.8. Notices. (a) Any communication, demand or notice
to be given  hereunder  will be duly  given  when  delivered  in  writing  or by
telecopy to a party at its address as indicated  below or such other  address as
such party may specify in a notice to each other party hereto.  A communication,
demand or notice given pursuant to this Section 9.08 shall be addressed:

     If to the Company, to

                           Miravant Medical Technologies
                           7408 Hollister Avenue
                           Santa Barbara, California 93117

                           Telecopy:  (805) 685-6038

                           Attention:  Gary S. Kledzik

     with a copy (which, in and of itself, shall not constitute notice) to

                           Nida & Maloney PC
                           800 Anacapa Street
                           Santa Barbara, California 93101

                           Telecopy:         (805) 568-1955

                           Attention:  Joseph E. Nida

     and

                           Wilson Sonsini Goodrich & Rosati
                           650 Page Mill Road
                           Palo Alto, California 94304

                           Telecopy:  (650) 493-6811

                           Attention:  John T. Sheridan


     If to the Initial Holder, to

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:  (908) 470-8047


                           Attention:  Treasurer

     and

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:  (908) 306-4485

                        Attention: Senior Vice President of Business Development

     and
                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:  (908) 306-4489

                           Attention:  General Counsel

     with a copy (which, in and of itself, shall not constitute notice) to

                           Sullivan & Cromwell
                           125 Broad Street
                           New York, New York 10004

                           Telecopy:           (212) 558-3588

                           Attention: Neil T. Anderson,
                                                Matthew G. Hurd
                                                and Martin J. Travers

                  (b) Unless  otherwise  provided to the  contrary  herein,  any
notice  which is required  to be given in writing  pursuant to the terms of this
Agreement may be given by telecopy.


                  Section  IX.9.  Separability.  In case  any one or more of the
provisions  contained  in this  Agreement  or any Warrant  Certificate  shall be
invalid,  illegal or  unenforceable  in any respect under any law, the validity,
legality  and  enforceability  of the  remaining  provisions  contained  in this
Agreement  or any  Warrant  Certificate  shall  not in any  way be  affected  or
impaired thereby.

                  Section IX.10.  Persons  Benefitting.  This Agreement shall be
binding  upon  and  inure  to the  benefit  of any  Holders  (each of whom is an
intended  third  party  beneficiary)  and  the  Company,  and  their  respective
successors,  assigns,  beneficiaries,  executors and administrators.  Nothing in
this  Agreement  is  intended or shall be  construed  to confer upon any Person,
other  than  the  Company  and  the  Holders  (and  such  successors,   assigns,
beneficiaries,  executors and administrators),  any right, remedy or claim under
or by reason of this Agreement or any part hereof.

     Section IX.11.  Counterparts.  This Agreement may be executed in any number
of  counterparts,  each of which shall be deemed an  original,  but all of which
together constitute one and the same instrument.

     Section IX.12.  Headings.  The descriptive headings of the several Sections
of this Agreement are inserted for  convenience  and shall not control or affect
the meaning or construction of any of the provisions hereof.

                  Section  IX.13.  Remedies.  In the  event of a  breach  by the
Company or by a Holder of any of their  obligations  under this Agreement or any
Warrant Certificate, each Holder or the Company, as the case may be, in addition
to being entitled to exercise all rights granted by law,  including  recovery of
damages,  will be  entitled  to specific  performance  of its rights  under this
Agreement and such Warrant Certificate. The Company and the Initial Holder agree
that monetary  damages would not be adequate  compensation for any loss incurred
by reason of a breach by it of any of the  provisions  of this  Agreement or any
Warrant  Certificate  and hereby further agrees that, in the event of any action
for specific  performance in respect of such breach,  it shall waive the defense
that a remedy at law would be adequate.


     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed, as of the date first above written.

                                                 MIRAVANT MEDICAL TECHNOLOGIES


                       By:________________________________
                                      Name:
                                     Title:


                                                 PHARMACIA & UPJOHN, INC.


                       By:________________________________
                                      Name:
                                     Title:


                                                          EXHIBIT A

                                         [FORM OF WARRANT CERTIFICATE]

        THIS WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
          1933, AS AMENDED, OR ANY STATE SECURITIES LAWS, AND MAY NOT
             BE SOLD OR OFFERED FOR SALE UNLESS REGISTERED PURSUANT
                 TO THERETO OR UNLESS AN EXEMPTION THEREFROM IS
                                   AVAILABLE.


                        WARRANTS TO PURCHASE COMMON STOCK
                        OF MIRAVANT MEDICAL TECHNOLOGIES


No._______                                     Certificate for ______ Warrants


                  This certifies that , or registered assigns, is the registered
holder of the number of Warrants  set forth  above.  Each  Warrant  entitles the
holder thereof (a "Holder"),  subject to the provisions  contained herein and in
the Warrant  Agreement  referred to below,  to purchase,  from Miravant  Medical
Technologies,  a Delaware  corporation (the "Company"),  the number of shares of
the  Company's  common  stock,  par value $.01 per share (the  "Common  Stock"),
provided  in the Warrant  Agreement,  at an exercise  price of  $__________  per
Warrant and subject to all of the terms and  conditions set forth in the Warrant
Agreement.  At the  sole  election  of the  Company,  upon the  exercise  of any
Warrant, the Company may pay to the Holder a certain amount of cash, as provided
in the Warrant Agreement, in lieu of delivering the shares of Common Stock.

                  This Warrant  Certificate  is issued  under and in  accordance
with the  Warrant  Agreement,  dated as of o,  1999 (the  "Warrant  Agreement"),
between the Company and Pharmacia & Upjohn, Inc. (the "Initial Holder"),  and is
subject to the terms and provisions  contained in the Warrant Agreement,  to all
of which terms and provisions the Holder of this Warrant Certificate consents by
acceptance  hereof.  The  Warrant  Agreement  is hereby  incorporated  herein by
reference  and made a part  hereof.  Reference  is  hereby  made to the  Warrant
Agreement for a full statement of the respective rights,  limitations of rights,
duties,  obligations and immunities thereunder of the Company and the Holders of
the Warrants.

                  This Warrant Certificate shall terminate and be void as of the
Close of Business on _________, 200__.


                  As provided in the Warrant  Agreement and subject to the terms
and conditions therein set forth, the Warrants shall be exercisable from time to
time on any Business Day ending on the Expiration Date.

                  The number of shares of Common Stock issuable,  and the amount
of cash payable,  upon the exercise of each Warrant are subject to adjustment as
provided in the Warrant Agreement.

                  Upon payment therefor,  all shares of Common Stock issued upon
the exercise of Warrants shall be duly  authorized,  validly issued,  fully paid
and  nonassessable  free of  preemptive  rights and free from all taxes,  liens,
charges and security interests with respect to the issuance thereof.

                  In order to exercise a Warrant,  the registered  holder hereof
must surrender  this Warrant  Certificate to the Registrar for the Warrants (the
"Registrar")  with the form of election on the reverse hereof or attached hereto
duly  executed,  together with payment of the Exercise  Price then in effect for
the  share(s) of Common  Stock as to which the  Warrant(s)  represented  by this
Warrant  Certificate  are submitted  for exercise,  all subject to the terms and
conditions  hereof and of the Warrant  Agreement.  Any such  payment of the cash
Exercise  Price shall be by certified or official bank check or wire transfer to
the Company of same day funds.

                  The Company  shall pay all  transfer,  stamp and other similar
taxes that may be imposed in respect of the issuance or delivery of Warrants, or
in respect of the  issuance  or  delivery  of any  securities  upon  exercise of
Warrants.  The Company shall not be required,  however,  to pay any tax or other
charge imposed in connection  with any transfer  involved in the issuance of any
certificate  for  shares  of Common  Stock or other  securities  underlying  the
Warrants  or payment  of cash to any  Person  other than the Holder of a Warrant
Certificate  surrendered upon the exercise or purchase of a Warrant, and in case
of such  transfer  or payment,  the  Company  shall not be required to issue any
stock  certificate  or pay any cash until such tax or other charge has been paid
or it has been established to the Company's reasonable satisfaction that no such
tax or other charge is due.


                  Subject to the Warrant Agreement, this Warrant Certificate and
all rights hereunder are transferable by the registered  holder hereof, in whole
or in part,  on the Warrant  Register of the  Company,  upon  surrender  of this
Warrant  Certificate  to the  Registrar,  duly endorsed by, or  accompanied by a
written  instrument of transfer in form  reasonably  satisfactory to the Company
duly executed by the Holder  hereof or his attorney duly  authorized in writing.
Upon any partial  transfer,  the Company will issue and deliver to such holder a
new  Warrant  Certificate  or  Certificates  with  respect to any portion not so
transferred.

                  No service  charge  shall be made for any transfer or exchange
of this Warrant Certificate, but the Company may require payment from the Holder
of this  Warrant  Certificate  of a sum  sufficient  to cover any stamp or other
governmental  charge  or tax that may be  imposed  in  connection  with any such
transfer or exchange.

                  Each taker and holder of this Warrant  Certificate,  by taking
or holding the same,  consents  and agrees that this Warrant  Certificate,  when
duly endorsed in blank,  shall be deemed  negotiable  and that when this Warrant
Certificate shall have been so endorsed, the holder hereof may be treated by the
Company,  the  Registrar  and  all  other  persons  dealing  with  this  Warrant
Certificate  as the  absolute  owner  hereof for any  purpose  and as the person
entitled to exercise the rights represented hereby, or to the transfer hereof on
the  register  of the Company  maintained  by the  Registrar,  any notice to the
contrary notwithstanding,  but until such transfer on such register, the Company
and the  Registrar may treat the  registered  Holder hereof as the owner for all
purposes.

                  This Warrant Certificate and the Warrant Agreement are subject
to amendment as provided in the Warrant Agreement.

                  All terms used in this Warrant Certificate that are defined in
the Warrant  Agreement  shall have the meanings  assigned to them in the Warrant
Agreement.

     Copies of the  Warrant  Agreement  are on file at the office of the Company
and may be  obtained by writing to the Company at the  following  address:  7408
Hollister Avenue, Santa Barbara,  California 93117,  Attention:  Chief Financial
Officer.

Dated: __________.


                                                 MIRAVANT MEDICAL TECHNOLOGIES


                                      By: 
                                      Name:
                                     Title:


                                      By: 
                                      Name:
                                     Title:



                              ELECTION TO EXERCISE

                 (To be executed only upon exercise of Warrant)

TO MIRAVANT MEDICAL TECHNOLOGIES:

                  The  undersigned   irrevocably  exercises  __________  of  the
Warrants  for, at your  election,  either (i) the Shares Amount or (ii) the Cash
Amount,  and  herewith  makes  payment of  $__________  (such  payment  being by
certified  or  official  bank  check  payable to the order of  Miravant  Medical
Technologies),  all at the  Exercise  Price and on the terms and  subject to the
conditions specified in the within Warrant Certificate and the Warrant Agreement
therein referred to,  surrenders this Warrant  Certificate and all right,  title
and interest therein to Miravant Medical Technologies, Inc. and directs that any
shares of  Common  Stock  deliverable  upon the  exercise  of such  Warrants  be
registered in the name and  delivered at the address  specified on the following
page,  or any Cash Amount be wired to the  account  specified  on the  following
page.

Date:                


(Signature of Holder)



(Street Address)



(City)            (State)    (Zip Code)





Securities and/or check to be issued to:



Taxpayer identification number:



Name:



Street Address:



City, State and Zip Code:



Any  unexercised  Warrants  evidenced by the within  Warrant  Certificate  to be
issued to:



Taxpayer identification number:



Wire transfer instructions:


                                              FORM OF ASSIGNMENT


                  FOR VALUE RECEIVED,  the undersigned  registered holder of the
within  Warrant  Certificate  hereby  sells,  assigns,  and  transfers  unto the
Assignee(s)  named below (including the undersigned with respect to any Warrants
constituting a part of the Warrants evidenced by the within Warrant  Certificate
not being assigned hereby) all of the rights of the undersigned under the within
Warrant Certificate, with respect to the number of Warrants set forth below:


                                   Social Security or      
Names of            Address        Taxpayer Identification  Number of Warrants
Assignees                          Number of Assignee(s)









and                    does  hereby  irrevocably   constitute  and  appoint  the
                       undersigned's attorney to make such transfer on the books
                       of  maintained  for  that  purpose,  with  full  power of
                       substitution in the premises.


Dated: __________.



(Signature of Holder)


                                                 (Street Address)


                                                 (City)(State)        (Zip Code)
                                              EXHIBIT B




                                              [BOARD RESOLUTIONS]



                                                   [To come]




                               SECURITY AGREEMENT


     SECURITY  AGREEMENT,  dated  as of  ___,  1999,  between  MIRAVANT  MEDICAL
TECHNOLOGIES,  a Delaware corporation ("Debtor"),  and __, a Swedish corporation
("Secured Party").

     1. Grant of Security Interest. Debtor, for valuable consideration,  receipt
of which is hereby  acknowledged,  hereby grants to Secured  Party,  in order to
secure the  payment  when due,  whether by  acceleration  or  otherwise,  of the
Indebtedness (as that term is defined below):

     (a) A security interest in, and Debtor agrees and acknowledges that Secured
Party has and shall  continue to have a security  interest in any and all of the
following property of Debtor,  whenever acquired or arising and wherever located
(collectively, the "Trademarks"):

                         (i) each of the  trademarks,  and rights and  interests
                    protectible  as trademarks  which are  presently,  or in the
                    future may be, owned,  created,  acquired,  or used (whether
                    pursuant to a license or otherwise)  by Debtor,  in whole or
                    in part,  and all  trademark  rights  with  respect  thereto
                    throughout  the  world,   including  all  proceeds   thereof
                    (including  license  royalties and proceeds of  infringement
                    suits),  and rights to renew and extend such  trademarks and
                    trademark rights;

                         (ii) all of Debtor's  right,  title and interest in and
                    to the  trademarks  and  trademark  registrations  listed on
                    Schedule  1  attached  hereto,  as the same  may be  updated
                    hereafter from time to time;

                         (iii)  all of  Debtor's  rights to  register  trademark
                    claims  under  any  state  or  federal   trademark   law  or
                    regulation  of any foreign  country and to apply for,  renew
                    and extend trademark registrations and trademark rights, all
                    of  Debtor's  rights (but not  obligations)  to sue or bring
                    opposition or cancellation proceedings in the name of Debtor
                    or in the name of Secured Party for past, present and future
                    infringements  of  trademarks,  registrations,  or trademark
                    rights  and all of  Debtor's  rights  (but not  obligations)
                    corresponding  thereto in the United  States and any foreign
                    country, and the associated goodwill;

                         (iv)   all   general   intangibles   relating   to  the
                    Trademarks; and

                         (v) the  products,  proceeds and  accessions of any and
                    all of the foregoing (including, without limitation, license
                    royalties  and proceeds of  infringement  suits) and, to the
                    extent not otherwise included, all payments under insurance,
                    or any indemnity, warranty, or guaranty payable by reason of
                    loss  or  damage  to  or  otherwise   with  respect  to  the
                    Trademarks.

     (b) A  security  interest  in and  assignment  of,  and  Debtor  agrees and
acknowledges  that  Secured  Party has and  shall  continue  to have a  security
interest in and assignment of, any and all of the following  property of Debtor,
whenever acquired or arising and wherever located (together with the Trademarks,
the "Collateral"):

     (i) any and all of Debtor's Tangibles (as that term is defined below);

     (ii) any and all of Debtor's  Intangibles  (as that term is defined below);
and

     (iii)  the  products,  proceeds  and  accessions  of  any  and  all  of the
foregoing.

     Notwithstanding  the foregoing and only to the extent such  prohibition  is
enforceable under applicable law, the security interest granted herein shall not
extend to and the term  "Collateral"  shall not include any property,  rights or
licenses to the extent the granting of a security  interest therein (1) would be
contrary to applicable law or (2) is prohibited by or would constitute a default
under any agreement or document governing such property, rights or licenses that
is in effect on the date of this Agreement.

     2.  Definitions.  (a) The term  "Credit  Agreement"  shall  mean the Credit
Agreement,  of even date  herewith,  between  Debtor,  as borrower,  and Secured
Party, as lender, as the same may be amended from time to time.

     (b) The term  "Credit  Documents"  shall have the meaning  assigned to such
term in the Credit Agreement.

     (c) The term  "Event of Default"  shall have the  meaning  assigned to such
term in the Credit Agreement.

     (d) The term "Indebtedness" as used herein shall mean the following:


(i)      Any and all  obligations  of Debtor  with  respect  to the  payment  of
         principal  and interest or otherwise to Secured Party on the loans made
         by Secured Party (and the promissory notes evidencing such loans) under
         the Credit Agreement, and any extension or renewals of such loans; and

(ii)     any and all other obligations of Debtor to Secured Party arising solely
         under the Credit Agreement and the other Credit Documents and excluding
         any other agreements between the parties and their affiliates,  however
         created or evidenced, whether now existing or hereafter arising and any
         extension or renewals thereof.

     (e) The term  "Intangibles"  as used herein includes and shall be deemed to
mean  "accounts,"   "instruments,"   "documents,"   "chattel  paper,"  "drafts,"
"checks," and "general intangibles" and each of them, as the foregoing terms are
defined in the  Uniform  Commercial  Code as in effect in the State of New York,
excluding the Trademarks, and, without limitation, shall include:

(i) the following  securities (the "Securities") hereby delivered and pledged to
Secured Party:

                          Miravant Cardiovascular, Inc.
                             Miravant Systems, Inc.
                         Miravant Pharmaceuticals, Inc.
                           Ramus Medical Technologies
                         Xillix Technologies Corporation

(ii) the  following  rights and interests in and to patents  (collectively,  the
"Patents"):

                              (A) each of the  patents  and patent  applications
                  which are presently,  or in the future may be, owned,  issued,
                  acquired, or used (whether pursuant to a license or otherwise)
                  by Debtor,  in whole or in part,  and all patent  rights  with
                  respect thereto  throughout the world,  including all proceeds
                  thereof   (including   license   royalties   and  proceeds  of
                  infringement  suits),  foreign  filing  rights,  and rights to
                  extend such patents and patent rights;

                              (B) all of Debtor's  right,  title and interest in
                  and to the patents and patent  applications listed on Schedule
                  2 attached hereto,  as the same may be updated  hereafter from
                  time to time;


                              (C) all of Debtor's  right,  title and interest in
                  and to all patentable  inventions,  all of Debtor's  rights to
                  file  applications  for patents  under United  States  federal
                  patent law or the laws or regulations of any foreign  country,
                  all of Debtor's rights to request reexamination and/or reissue
                  of patents,  all of Debtor's  rights (but not  obligations) to
                  sue or bring  infringement or interference  proceedings in the
                  name of  Debtor  or in the name of  Secured  Party  for  past,
                  present,  or  future  infringements  of  patents,  and  all of
                  Debtor's rights (but not obligations) corresponding thereto in
                  the United States and any foreign country;

                              (D)  all  general  intangibles   relating  to  the
                  Patents; and

                              (E) all  proceeds of any and all of the  foregoing
                  (including without limitation,  license royalties and proceeds
                  of  infringement  suits)  and,  to the  extent  not  otherwise
                  included,  all payments  under  insurance,  or any  indemnity,
                  warranty,  or guaranty  payable by reason of loss or damage to
                  or otherwise with respect to the Patents.

(iii) the following rights and interests in and to trade secrets  (collectively,
the "Trade Secrets"):

                              (A)  each of the  trade  secrets  and  proprietary
                  information  which are  presently,  or in the  future  may be,
                  owned,  created,  acquired,  or used  (whether  pursuant  to a
                  license  or  otherwise)  by  Debtor,  in  whole  or  in  part,
                  including all proceeds thereof  (including  license  royalties
                  and  proceeds of  misappropriation  suits),  and all  tangible
                  property  embodying  the trade secrets  (including  documents,
                  records,    computer   tapes   or   disks,   customer   lists,
                  sales/pricing   information,   photographs,   flow   diagrams,
                  specification  sheets,  source  codes,  object codes and other
                  physical manifestations of the foregoing);

                              (B) all of  Debtor's  right  to sue in the name of
                  Debtor or in the name of Secured Party for past, present,  and
                  future  misappropriation  of the trade  secrets and all rights
                  (but not  obligations)  corresponding  thereto  in the  United
                  States and any foreign country;

                              (C) all general intangibles  relating to the Trade
                  Secrets; and


                              (D) all  proceeds of any and all of the  foregoing
                  (including, without limitation, license royalties and proceeds
                  of  infringement  suits)  and,  to the  extent  not  otherwise
                  included,  all payments  under  insurance,  or any  indemnity,
                  warranty,  or guaranty  payable by reason of loss or damage to
                  or otherwise with respect to the Trade Secrets.


                         (f) The term  "Permitted  Liens" shall have the meaning
                    assigned to such term in the Credit Agreement.

                         (g) The term  "Tangibles"  as used herein  includes and
                    shall be  deemed  to mean  "inventory"  and  "equipment"  as
                    defined in the Uniform  Commercial  Code as in effect in the
                    State  of New  York  and all  goods  and  tangible  personal
                    property now owned or hereafter acquired by Debtor.

                         (h)  Terms  not  expressly  defined  herein  which  are
                    defined in the Uniform  Commercial  Code as in effect in the
                    State of New York  have the same  meaning  herein as in said
                    Code.

                  (i) As used in this  Security  Agreement  and when required by
the context,  each number  (singular and plural) shall include all numbers,  and
each  gender  shall  include  all  genders;  and  unless the  context  otherwise
requires, the word "person" shall include "corporation, firm or association."

     3.  Warranties,  Covenants  and  Agreements  of  Debtor.  Debtor  warrants,
covenants and agrees that:

     (a) Except for the security interest granted hereby and except as permitted
by the agreements under which the Indebtedness is being incurred, Debtor is, and
as to Collateral  acquired after the date hereof Debtor shall and will be at the
time of acquisition the owner and holder of the Collateral free from any adverse
claim,  security interest,  encumbrance,  lien, charge, or other right, title or
interest of any person other than Secured Party and other than Permitted  Liens,
and covenants  that at all times the  Collateral  will be and remain free of all
such adverse claims,  security  interests,  or other liens or encumbrances other
than Permitted Liens. Debtor has full power and lawful authority to sell, assign
and transfer the  Collateral  to Secured  Party and to grant to Secured  Party a
first  and prior  security  interest  therein,  prior to all  liens  other  than
Permitted  Liens,  as  herein  provided;  the  execution  and  delivery  and the
performance  hereof are not in  contravention of any charter or by-law provision
or of any  indenture,  agreement or undertaking to which Debtor is a party or by
which Debtor or its property  are bound;  and Debtor will defend the  Collateral
against all claims and demands of all persons at any time  claiming  the same or
any interest  therein.  Any officer,  agent or  representative  acting for or on
behalf of Debtor  in  connection  with this  Security  Agreement  or any  aspect
thereof,  or entering into or executing this Security Agreement or any financing
statement on behalf of Debtor,  has been duly  authorized to do so, and is fully
empowered  to act for and  represent  Debtor in  connection  with this  Security
Agreement and all matters related thereto or in connection therewith.

     (b)(i) Except for financing  statements or security  agreements  evidencing
Permitted  Liens,  Debtor has not heretofore  signed any financing  statement or
security  agreement  which covers any of the  Collateral,  and no such financing
statement or security agreement is now on file in any public office.

(ii) As long as any  amount  remains  unpaid on any of the  Indebtedness  or any
additional borrowings may be made by Debtor under any agreements entered into in
connection  with the  Indebtedness,  except as  expressly  permitted by any such
agreements,  (i) Debtor will not enter into or execute any security agreement or
any  financing  statement  covering the  Collateral,  other than those  security
agreements  and financing  statements  in favor of Secured  Party  hereunder and
except for those evidencing  Permitted Liens, and further (ii) there will not be
on file in any public  office any  financing  statement  or  statements  (or any
documents or papers filed as such) covering the Collateral, other than financing
statements in favor of Secured Party  hereunder and except for those  evidencing
Permitted  Liens,  unless in any case the prior written consent of Secured Party
shall have been obtained.


(iii) Debtor  authorizes  Secured  Party to file,  in  jurisdictions  where this
authorization will be given effect, a financing statement signed only by Secured
Party covering the  Collateral,  and hereby  appoints  Secured Party as Debtor's
attorney-in-fact  to sign and file any such  financing  statements  covering the
Collateral.  At the request of Secured Party,  Debtor will join Secured Party in
executing such documents as Secured Party may reasonably determine, from time to
time to be necessary or desirable  under  provisions of any  applicable  Uniform
Commercial  Code in effect where the  Collateral  is located or where the Debtor
conducts  business;  without  limiting the generality of the  foregoing,  Debtor
agrees to join Secured Party,  at Secured Party's  request,  in executing one or
more financing statements in form satisfactory to Secured Party, and Debtor will
pay the costs of filing or recording  the same,  or of filing or recording  this
Security  Agreement,  in all  public  offices at any time and from time to time,
whenever filing or recording of any such financing statement or of this Security
Agreement is deemed by Secured  Party to be  necessary or desirable  and Secured
Party  will  provide  Debtor  with  "as-filed"  copies  of all such  filings  or
recordings.  In  connection  with the  foregoing,  it is agreed  and  understood
between the parties hereto (and Secured Party is hereby  authorized to carry out
and implement this agreement and  understanding  and Debtor hereby agrees to pay
the costs  thereof)  that  Secured  Party may,  at any time or times,  file as a
financing  statement any  counterpart,  copy, or  reproduction  of this Security
Agreement.

     (c) Except as specifically otherwise permitted or provided herein, Debtor's
Tangibles  shall  remain in  Debtor's  possession  and  control  at all times at
Debtor's  risk of loss,  and are now kept and at all times  shall be kept at the
addresses and  locations  set forth on Schedule 3 hereto.  If Debtor is using or
will use all or any part of the advances made,  obligations  incurred, or credit
extended  by  Secured  Party to  acquire  rights  in,  possession  of, or use of
Tangibles,  then Debtor agrees that,  within 30 days after Debtor first receives
possession  thereof,  such  Tangibles  will be brought to and kept at one of the
addresses and locations set forth on Schedule 1 hereto.

     (d)  Debtor  will  promptly  notify  Secured  Party of any change in any of
addresses or locations  set forth on Schedule 1 hereto and of any new  addresses
or locations  where Tangibles or other goods,  documents,  or instruments are or
may be kept,  and Debtor will not remove  (except in the ordinary  course of its
business) the Tangibles or such goods,  documents,  or instruments,  or any part
thereof,  from the addresses and locations described and specified above without
the prior written notice to Secured Party.

     (e) With  respect  to  accounts,  general  intangibles  and  chattel  paper
included in the  Collateral,  Debtor  represents  and  warrants  and agrees that
Debtor's books and records with respect to such  Collateral are and will be kept
at Debtor's office located at 7408 Hollister Avenue,  Santa Barbara,  California
93117, and such address is that of Debtor's chief executive offices;  and Debtor
further  covenants  and agrees that Debtor will not change such address  without
first  notifying  Secured  Party in writing of such  change,  filing such new or
additional  financing  statements and making such other filings or recordings as
Secured Party shall deem necessary or appropriate,  and providing  Secured Party
with "as-filed" copies of all such filings or recordings.

     (f) Debtor further  covenants and agrees that, if any certificates of title
or similar  documents are at any time issued or outstanding  with respect to any
of the Collateral, Debtor will promptly advise Secured Party thereof, and Debtor
will promptly  cause the interest of Secured Party to be properly noted thereon,
and if any  certificates  of  title  or  similar  documents  are  so  issued  or
outstanding  at the time this Security  Agreement is executed by or on behalf of
Debtor,  then Debtor shall have caused the interest of Secured  Party so to have
been  properly  noted at or before the time of such  execution;  and Debtor will
further  promptly  deliver to  Secured  Party any such  certificate  of title or
similar document.

     (g) Except as permitted in the Credit  Agreement  and except in the case of
sales of  inventory  in the  ordinary  course of business for cash or on payment
terms  customary in Debtor's  business which give rise to accounts  constituting
Collateral  hereunder,  Debtor  will  not  sell or  offer  to sell or  otherwise
transfer  or  encumber  or dispose of the  Collateral  or any  interest  therein
without the prior written consent of Secured Party.

     (h) Debtor will not release or surrender any guaranty, suretyship agreement
or security for any of Debtor's Intangibles at any time or times except incident
to payment in full thereof.

     (i) Debtor  will take all  action  reasonably  necessary  to  maintain  and
preserve all security for Debtor's Intangibles at all times as valid, subsisting
and  perfected  as to all the  property  affected  and  covered  thereby  and to
maintain  the priority  and  validity of the  security  for the  Intangibles  as
against the rights, claims and interests of all other persons;  provided that if
Debtor,  in its prudent business  judgment,  determines that (A) such rights are
immaterial  or  unneeded  in its  business  or (B)  it is in  Debtor's  business
interest not to maintain or preserve such rights, Debtor shall so notify Secured
Party and  Secured  Party  shall have the  opportunity  to review  the  proposed
inaction and, where  appropriate,  to take action on Debtor's  behalf to prevent
such lapse or require Debtor to transfer such rights to Secured Party.

     (j)  Notwithstanding  anything  to the  contrary  contained  herein,  it is
understood  and agreed that if for any reason  Tangibles are at any time kept or
located at  locations  other  than those  specified  or which may  hereafter  be
consented to by Secured Party,  Secured Party shall nevertheless have and retain
a security interest therein.

                  4.  Special Provisions - Intangibles.

     (a) Secured Party shall have the right,  exercisable  at any time following
the  occurrence  and  during the  continuance  of an Event of  Default,  to take
control of all proceeds of the  Collateral  (whether  cash  proceeds or non-cash
proceeds) and to notify any and all account debtors,  lessees, or other obligors
to make payment on any and all  accounts,  leases,  or  obligations  directly to
Secured Party; and, in such  circumstances,  Debtor will upon request of Secured
Party  likewise  notify  any and all  such  account  debtors,  lessees  or other
obligors to make payment directly to Secured Party. Upon demand by Secured Party
following the occurrence and during the continuance of an Event of Default,  all
proceeds of  Intangibles,  whether  such  proceeds be cash  proceeds or non-cash
proceeds, received by Debtor shall be held in trust by Debtor for the account of
Secured Party, shall not be commingled with any other funds, accounts, monies or
property of Debtor, and shall be forthwith accounted for, paid over, transmitted
and delivered to Secured  Party in the form as received by Debtor  promptly upon
receipt thereof by Debtor.

     (b) At any time after  demand as  hereinabove  provided,  and in any event,
without  demand,  after any of the  Indebtedness  shall  become due,  whether by
acceleration  or  otherwise  (and  so long as  such  Indebtedness  shall  remain
unpaid),  and at any time after the  occurrence  of an Event of Default  (and so
long as such Event of Default shall be continuing), Secured Party shall have the
right in its own name or in the name of  Debtor  to  demand,  collect,  receive,
receipt for, sue for, compound and give acquittance for, any and all amounts due
or to become due on the  Intangibles  and to  endorse  the name of Debtor on all
checks, drafts,  commercial paper and other instruments given in payment or part
payment  thereof,  and in its  discretion  to settle,  compromise,  prosecute or
defend any action,  claim or proceeding with respect thereto which Secured Party
may deem  necessary or  appropriate to protect and preserve and realize upon the
security interest and collateral  assignment of Secured Party in the Intangibles
and the proceeds thereof and security therefor  including,  without  limitation,
the right to sell, assign, pledge, transfer and make any agreement respecting or
otherwise deal with the Intangibles; provided, however, that all dispositions of
Intangibles shall be made in a commercially reasonable manner in accordance with
the Uniform Commercial Code and other applicable law.

     (c)  Returned  or  repossessed  goods  arising  from or  relating to any of
Debtor's Intangibles shall be and become a part of the Tangibles included in the
Collateral hereunder.

     (d) Until the  Indebtedness  shall become due,  whether by  acceleration or
otherwise (and so long as such Indebtedness shall remain unpaid), or there shall
occur  an Event  of  Default  (and so long as such  Event  of  Default  shall be
continuing),  Debtor shall be entitled to vote the Securities and to receive all
cash distributions  thereon.  Debtor covenants and agrees to deliver promptly to
Secured Party all  securities  or other  property of any kind  distributed  as a
dividend or otherwise with respect to the Securities,  said additional  property
to be held as Collateral hereunder.  Debtor agrees that at any time after any of
the  Indebtedness  shall have become due,  whether by  acceleration or otherwise
(and so long as such  Indebtedness  shall remain unpaid),  and at any time after
the  occurrence  of an Event of  Default  (and so long as such  Event of Default
shall be  continuing),  Secured Party may transfer  Securities  into the name of
Secured Party or its nominee.

     (e) If, before the Indebtedness  shall have been satisfied in full,  Debtor
shall  obtain  rights to any new Patent,  Trade Secret or  Trademark,  or become
entitled to the benefit of any Patent, Trade Secret or Trademark, the provisions
of Section 1 of this Security  Agreement shall  automatically  apply thereto and
Debtor shall give to Secured Party prompt notice thereof in writing.

     (f) Upon notice of new Patent or Trademark rights or  entitlements,  Debtor
authorizes  Secured Party to modify this agreement by amending Schedules 1 and 2
hereof to include such Patents or Trademarks  and agrees to execute and file any
such reports,  records or documents reasonably deemed necessary by Secured Party
to perfect its interest in such property.

     5. Special  Provisions -  Tangibles.  (a) Any of Debtor's  Tangibles in the
possession of persons other than Debtor must be represented by documents  issued
by the person in possession  thereof, in form acceptable to Secured Party, which
documents must,  upon the reasonable  request of the Secured Party, be delivered
to Secured Party and must be either  negotiable  documents issued in the name of
Debtor or  non-negotiable  documents  issued in the name of Secured  Party or on
which the  security  interest  of  Secured  Party has been  noted by the  issuer
thereof. Debtor warrants that all such documents are and shall be genuine, valid
and in all  respects  what they purport to be and that the  Tangibles  described
therein will be identified or fungible  portions of an identified mass, and that
said  documents are and will be subject to no terms or conditions  other than is
noted therein or thereon.

     (b) At any time after any of the Indebtedness  shall become due, whether by
acceleration  or  otherwise  (and  so long as  such  Indebtedness  shall  remain
unpaid),  and at any time after the  occurrence  of an Event of Default  (and so
long as such Event of Default  shall be  continuing),  all  proceeds of Debtor's
Tangibles,  whether cash proceeds or non-cash proceeds,  and including,  without
limitation,  proceeds that  constitute  Intangibles  or that are included in the
Collateral  as  Intangibles,   and  proceeds  that  represent  the  proceeds  of
Intangibles,  shall be received  and held by Debtor in trust for Secured  Party,
shall not be commingled  with any other funds,  accounts,  monies or property of
Debtor,  and shall be promptly accounted for, paid over and delivered to Secured
Party in the form as received by Debtor upon receipt thereof by Debtor.

     (c)  Debtor  will  promptly  report  to  Secured  Party any  occurrence  or
condition known to or which becomes known to Debtor having any material  adverse
effect upon Debtor's Tangibles.

     6. Further  Agreements  Between the Debtor and Secured  Party.  (a) Secured
Party  shall  never be under any  obligation  to  collect,  attempt to  collect,
protect or enforce the Collateral or any security therefor, which Debtor agrees,
and  undertakes  to do at Debtor's  expense,  but Secured Party may do so in its
discretion at any time after any of the  Indebtedness  shall become due, whether
by  acceleration  or otherwise  (and so long as such  Indebtedness  shall remain
unpaid),  and at any time after the  occurrence  of an Event of Default  (and so
long as such Event of Default shall be continuing), and at any such time Secured
Party shall have the right to take any steps by judicial process or otherwise it
may deem proper to effect the collection of all or any portion of the Collateral
or to  protect  or to enforce  the  Collateral  or any  security  therefor.  All
expenses (including, without limitation,  attorneys' fees and expenses) incurred
or paid by Secured Party in connection  with or incident to any such  collection
or attempt  to  collect  the  Collateral  or  actions to protect or enforce  the
Collateral  or any security  therefor  shall be borne by Debtor or reimbursed by
Debtor  to  Secured  Party  upon  demand.  The  proceeds  of  collection  of the
Intangibles or other proceeds  received by Secured Party as a result of any such
actions in collecting or enforcing or protecting the Collateral shall be held by
Secured  Party  without  liability  for  interest  thereon and may be applied by
Secured Party as Secured Party may deem appropriate toward payment of any of the
Indebtedness secured hereby in such order or manner as Secured Party may elect.

     (b) In the  event  Secured  Party  shall pay any such  taxes,  assessments,
interests,  costs,  penalties or expenses  incident to or in connection with the
collection of the  Collateral or protection or  enforcement of the Collateral or
any  security  therefor,  Debtor,  upon  demand of Secured  Party,  shall pay to
Secured Party the full amount thereof with interest at a rate per annum equal to
10% per annum in excess of the rate of  interest  on loans made  pursuant to the
Credit  Agreement;  and so long as Secured  Party  shall be entitled to any such
payment, this Security Agreement shall operate as security therefor as fully and
to the  same  extent  as it  operates  as  security  for  payment  of the  other
Indebtedness  secured  hereunder,  and for  the  enforcement  of such  repayment
Secured  Party shall have every right and remedy  provided  for  enforcement  of
payment of the Indebtedness.

     (c) In the  event  that the  Collateral  or any part  thereof  shall now or
hereafter become so related to particular real estate that an interest in it may
arise  under  the real  estate  laws of the state in which  such real  estate is
located,  then Debtor shall  immediately  notify  Secured Party of such fact and
take all steps and furnish all  information  as Secured  Party shall  reasonably
request for the purpose of  creating or  extending  (as the case may be) a valid
and  enforceable  lien in such  Collateral,  including  making  such  additional
filings  or  recordings,  at  Debtor's  expense,  as  Secured  Party  shall deem
necessary or appropriate.

     7.  Remedies.  (a) At any time after any of the  Indebtedness  shall become
due,  whether by  acceleration  or otherwise  (and so long as such  Indebtedness
shall  remain  unpaid),  and at any time  after  the  occurrence  of an Event of
Default (and so long as such Event of Default shall be continuing),  in addition
to any other remedies  provided for in any of the agreements  relating to any of
the Indebtedness or available under applicable law, Secured Party shall have and
may exercise with reference to the Collateral and Indebtedness any or all of the
rights and  remedies of a secured  party under the  Uniform  Commercial  Code in
effect in the State of New York,  and as otherwise  granted  herein or under any
other applicable law or under any other agreement executed by Debtor, including,
without  limitation,  the right and power to sell,  at public or private sale or
sales,  or otherwise  dispose of, lease or otherwise  utilize the Collateral and
any part or parts  thereof  in any manner  authorized  or  permitted  under said
Uniform  Commercial  Code after  default by a debtor,  and to apply the proceeds
thereof  toward  payment  of any  costs and  expenses  and  attorneys'  fees and
expenses   thereby   incurred  by  Secured  Party  and  toward  payment  of  the
Indebtedness  in such order or manner as Secured  Party may elect.  Specifically
and without limiting the foregoing, Secured Party may require Debtor to assemble
the  Collateral or any security  therefor and make it available to Secured Party
at a place to be designated by Secured  Party;  and Secured Party shall have the
right to take  possession  of all or any part of the  Collateral or any security
therefor  and of all  books,  records,  papers  and  documents  of  Debtor or in
Debtor's  possession or control relating to the Collateral which are not already
in Secured Party's possession,  and for such purpose may enter upon any premises
upon which any of the Collateral or any security  therefor or any of said books,
records, papers and documents are situated and remove the same therefrom without
any  liability  for  trespass  or  damages  thereby  occasioned.  To the  extent
permitted  by  law,  Debtor  expressly  waives  any  notice  of  sale  or  other
disposition  of the  Collateral  and all other  rights or  remedies of Debtor or
formalities  prescribed by law relative to sale or disposition of the Collateral
or exercise of any other right or remedy of Secured Party existing after default
hereunder;  and to the extent any such notice is required  and cannot be waived,
Debtor  agrees that if such notice is given in the manner  provided in Section 8
hereof at least 10 days before the time of the sale or disposition,  such notice
shall be deemed reasonable and shall fully satisfy any requirement for giving of
said notice.

     (b) At any time after any of the Indebtedness  shall become due, whether by
acceleration or otherwise (and so long as such Indebtedness remains unpaid), and
at any time after the  occurrence  of an Event of  Default  (and so long as such
Event of Default shall be  continuing),  Secured Party is expressly  granted the
right,  at its  option,  to transfer at any time to itself or to its nominee the
Collateral,  or any part  thereof,  and to receive  the  payments,  collections,
monies,  income,  proceeds or benefits  attributable or accruing  thereto and to
hold the same as security for the  Indebtedness  or to apply it on the principal
and interest or other amounts owing on any of the  Indebtedness in such order or
manner as Secured Party may elect.

     (c) All rights to marshalling of assets of Debtor, including any such right
with respect to the Collateral, are hereby waived by Debtor.

     8.  General.  (a) No  Impairment,  etc. The  execution and delivery of this
Security  Agreement in no manner  shall impair or affect any other  security (by
endorsement or otherwise) for the payment or performance of the Indebtedness and
no security  taken  hereafter  as security  for  payment or  performance  of the
Indebtedness shall impair in any manner or affect this Security  Agreement,  all
such  present and future  additional  security to be  considered  as  cumulative
security.  Any of the  Collateral  may be released from this Security  Agreement
without  altering,  varying or diminishing in any way the force,  effect,  lien,
security interest, or charge of this Security Agreement as to the Collateral not
expressly  released,  and, except for Permitted Liens,  this Security  Agreement
shall continue as a first and prior lien, security interest and charge on all of
the Collateral not expressly released until all the Indebtedness  secured hereby
has been paid or performed  in full.  Any future  assignment  of the interest of
Debtor in and to any of the  Collateral  shall not deprive  Secured Party of the
right  to  sell  or  otherwise  dispose  of or  utilize  all or any  part of the
Collateral as above provided or necessitate  the sale or disposition  thereof in
parcels or in severality.

     (b)  Liability  for  Deficiency.  This  Security  Agreement  shall  not  be
construed as relieving  Debtor from full liability on the  Indebtedness  and any
and all  future and other  indebtedness  secured  hereby and for any  deficiency
thereon.

     (c) Powers of Secured  Party.  After any of the  Indebtedness  shall become
due,  whether by  acceleration  or otherwise  (and so long as such  Indebtedness
shall remain  unpaid),  and after the  occurrence of an Event of Default (and so
long as such Event of Default shall be continuing), in protecting, exercising or
assuring its  interests,  rights and  remedies  under this  Security  Agreement,
Secured  Party may  receive,  open and dispose of mail  addressed  to Debtor and
execute,  sign and endorse  negotiable and other  instruments for the payment of
money,  documents of title and other  evidences of payment,  shipment or storage
for any form of Collateral or proceeds on behalf of and in the name of Debtor.

     (d) Subrogation. After any of the Indebtedness shall become due, whether by
acceleration  or  otherwise  (and  so long as  such  Indebtedness  shall  remain
unpaid),  and after the  occurrence  of an Event of Default (and so long as such
Event of Default shall be continuing),  Secured Party will be hereby  subrogated
to all of Debtor's  interests,  rights and remedies in respect to the Collateral
and  all  security  now or  hereafter  existing  with  respect  thereto  and all
guaranties and endorsements thereof and with respect thereto.

     (e) Any communication,  demand or notice to be given hereunder will be duly
given when  delivered  in writing or by  telecopy  to a party at its  address as
indicated  below or such other  address as such party may specify in a notice to
each other party hereto.  A  communication,  demand or notice given  pursuant to
this Security Agreement shall be addressed:

                  If to Debtor, to

                           Miravant Medical Technologies
                           7408 Hollister Avenue
                           Santa Barbara, California 93117

                           Telecopy:          (805) 685-6038

                           Attention:  Gary S. Kledzik

     with copies (which, in and of themselves, shall not constitute notice) to

                           Nida & Maloney PC
                           800 Anacapa Street
                           Santa Barbara, California 93101

                           Telecopy:   (805) 568-1955

                           Attention:  Joseph E. Nida

     and

                           Wilson Sonsini Goodrich & Rosati
                           650 Page Mill Road
                           Palo Alto, California 94304

                           Telecopy:   (650) 493-6811

                           Attention:  John T. Sheridan

     If to Secured Party, to

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:   (908) 470-8047

                           Attention:  Treasurer


     and

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:   (908) 306-4485

                           Attention:  Senior Vice President
                             of Business Development

     and

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:   (908) 306-4489

                           Attention:  General Counsel

     with a copy (which, in and of itself, shall not constitute notice) to

                           Sullivan & Cromwell
                           125 Broad Street
                           New York, New York 10004

                           Telecopy:   (212) 558-3588

                           Attention:   Neil T. Anderson,
                                 Matthew G. Hurd
                              and Martin J. Travers

or, as to any party,  to such other address as shall be designated by such party
in a prior written notice to each other party similarly given.

     (f) Severability.  The provisions of this Security Agreement are severable,
and if any clause or provision shall be held invalid and  unenforceable in whole
or in part in any jurisdiction,  then such invalidity or unenforceability  shall
affect only such clause or provision, or part thereof, in such jurisdiction, and
shall  not  in  any  manner  affect  such  clause  or  provision  in  any  other
jurisdiction, or any other clause or provision of this Security Agreement in any
jurisdiction.

     (g) No Duty to Preserve Collateral. Secured Party shall not be obligated to
take any steps  necessary  to preserve  any rights in the  Collateral  or in any
security  therefor  against any other  party,  which  obligation  Debtor  hereby
assumes.

     (h) No  Waiver.  No  delay or  omission  on the  part of  Secured  Party in
exercising  any right  hereunder  shall operate as a waiver of any such right or
any other right. A waiver on any one or more occasions shall not be construed as
a bar to or waiver of any right or remedy on any future  occasion.  The remedies
of Secured Party hereunder are  cumulative,  and the exercise of any one or more
of the remedies  provided for herein shall not be construed as an election or as
a waiver of any of the other  remedies of Secured  Party  provided for herein or
existing by law or otherwise.

     (i)  Assignment.  All rights of Secured Party  hereunder shall inure to the
benefit of its successors and assigns;  and all obligations of Debtor shall bind
its successors and assigns.

     (j)  GOVERNING  LAW.  THIS  SECURITY  AGREEMENT  SHALL BE  GOVERNED  BY AND
CONSTRUED  IN  ACCORDANCE  WITH THE LAWS OF THE  STATE OF NEW  YORK,  EXCEPT  AS
REQUIRED  BY  MANDATORY  PROVISIONS  OF LAW AND  EXCEPT TO THE  EXTENT  THAT THE
VALIDITY OR PERFECTION OF ANY OF THE SECURITY INTERESTS  HEREUNDER,  OR REMEDIES
HEREUNDER,  ARE GOVERNED BY THE LAWS OF A  JURISDICTION  OTHER THAN THE STATE OF
NEW YORK.

     IN WITNESS  WHEREOF,  the  Debtor  has duly  executed  and  delivered  this
Security Agreement as of the date first above written.


                                            MIRAVANT MEDICAL TECHNOLOGIES



                                            By: ______________________________
                                                Name:
                                                Title:


                                        


                                            By: ______________________________
                                                Name:
                                                Title:




                              Schedule 1


Trademarks


                              REGISTERED TRADEMARKS

                  Registration      Issue
Country  Number            Date             Owner/Assignee


                           [To Be Provided By Debtor]















                         PENDING TRADEMARK APPLICATIONS

                  Serial   File                               Attorney/
Country  Number   Date              Owner/Assignee            Agent    



                           [To Be Provided By Debtor]




                      Schedule 2

                                     Patents


                                 ISSUED PATENTS

                  Patent   Issue    Expiration
Country  Number   Date     Date             Owner/Assignee


                           [To Be Provided By Debtor]















                           PENDING PATENT APPLICATIONS


                  Serial   Filing   Owner/
Country  No.      Date     Assignee         Attorney/Agent


                           [To Be Provided By Debtor]




                                  Schedule 3

                             Locations of Tangibles

                           [To Be Provided By Debtor]


                          
                         REGISTRATION RIGHTS AGREEMENT


     REGISTRATION  RIGHTS AGREEMENT,  dated as of o, 1999 (this  "Agreement") by
and  between  Miravant  Medical   Technologies,   a  Delaware  corporation  (the
"Company"),  and Pharmacia & Upjohn, Inc., a Delaware Corporation  (collectively
with its Affiliates, the "Purchaser").


                              W I T N E S S E T H:

     WHEREAS, in connection with the Equity Investment  Agreement,  of even date
herewith,  between  the  Company  and  the  Purchaser  (the  "Equity  Investment
Agreement")  and the  Warrant  Agreement,  of even date  herewith,  between  the
Company and the Purchaser (the "Warrant Agreement" and, together with the Equity
Investment Agreement,  the "Purchase Agreements"),  the Company has agreed, upon
the terms and subject to the  conditions of said Purchase  Agreements,  to issue
and sell to the Purchaser shares of common stock of the Company,  par value $.01
per share (the "Common Stock") and warrants to purchase Common Stock, the shares
of Common Stock and the shares of Common  Stock  issuable  upon  exercise of the
Warrants being collectively referred to herein as the "Securities"; and

     WHEREAS,  to induce the  Purchaser  to execute  and  deliver  the  Purchase
Agreements,  the Company has agreed to provide certain registration rights under
the  Securities  Act  of  1933,  as  amended,  and  the  rules  and  regulations
thereunder,  or any similar  successor  statute  (collectively,  the "Securities
Act"), and applicable state securities laws with respect to the Securities.

     NOW THEREFORE,  in  consideration  of the premises and the mutual covenants
contained  herein and other good and  valuable  consideration,  the  receipt and
sufficiency  of which are hereby  acknowledged,  the Company  and the  Purchaser
hereby agree as follows:

                                    ARTICLE I

                                   Definitions

     Section  I.1.  Definitions.  Capitalized  terms used herein  shall have the
respective  meanings  set  forth  in the  Purchase  Agreement.  As  used in this
Agreement, the following terms shall have the following meanings:

     "Affiliate"  means any other  Person  directly or  indirectly  controlling,
controlled by, or under common control with, that Person.

     "Commission" means the Securities and Exchange Commission.

     "Person"  means  and  includes  natural  persons,   corporations,   limited
liability companies,  limited partnerships,  general  partnerships,  joint stock
companies,   joint   ventures,   associations,   companies,   trusts   or  other
organizations,  whether or not legal entities,  and governments and agencies and
political subdivisions thereof.

     "Qualified  Public  Offering"  means  an  underwritten   registered  public
offering of equity  securities of the Company,  which  offering  yields  minimum
gross proceeds of US$20,000,000.

     "1933 Act" means the  Securities  Act of 1933,  as amended and as it may be
amended from time to time, including the rules and regulations thereunder.

     "1934 Act" means the Securities  Exchange Act of 1934, as amended and as it
may  be  amended  from  time  to  time,  including  the  rules  and  regulations
thereunder.

                                   ARTICLE II

                               Registration Rights

     Section  II.1.  Demand  Rights.  (a) Upon  written  demand of  holders of a
majority of the  Securities,  the Company shall prepare and file a  registration
statement  under the 1933 Act covering an offering of such number of  Securities
as shall have been requested by such holder(s) in such demand, and shall use its
diligent efforts to cause such registration  statement to become effective,  all
in accordance  with the  provisions  of this  Agreement;  provided,  that if the
Company's Board of Directors determines in good faith that it would be seriously
detrimental to the Company to file such a registration  statement at the time of
such demand,  the Company shall have the right to defer filing such registration
statement for 120 days.  The Company shall only be required to cause up to three
(3) registration statements to become effective under this Section 2.01.

     (b)  Whenever  the Company  shall have  received a demand  pursuant to this
Section 2.01 to effect the  registration  of any  Securities,  the Company shall
promptly give written notice of such proposed  registration to all other holders
of Securities. Any such holder may, within 30 days after receipt of such notice,
request in writing that all of such holder's Securities,  or any portion thereof
designated by such holder, be included in the offering.

     (c) The Company shall proceed as expeditiously as possible after receipt of
a demand pursuant to this Section 2.01 to file a registration  statement and use
its best  efforts  to effect,  within 120 days after the giving of such  written
demand  (or, in the case of a demand made within 60 days prior to the end of the
Company's  then fiscal  year,  within 210 days after the giving of such  written
demand) the  registration of an offering under the 1933 Act. Such offering shall
include:

     (i) the  Securities  specified  in the  demand  given  pursuant  to Section
2.01(a); and

     (ii) all other  Securities  that the  holders  thereof  have  requested  be
included in the offering pursuant to Section  2.01(b);all of the extent required
to permit  the  holders of the  Securities  to  dispose  of such  Securities  in
compliance with applicable  law.  Unless  otherwise  recommended by the managing
underwriter  to facilitate  such  offering,  the Company shall have the right to
include in such offering  authorized but unissued shares of its Common Stock and
shares of its Common Stock held in its treasury that together constitute no more
than  20%  of the  aggregate  number  of  Securities  to be  offered.  No  other
outstanding  securities  of the Company  shall be included in such  registration
statement  unless,  and then only to the  extent  that,  in the  opinion  of the
representative of the underwriters participating in the sale and distribution of
the shares of Common Stock covered by such  registration  statement,  such other
outstanding  securities may be included in such registration  statement and sold
without adversely  affecting the sale of Securities  otherwise included therein.
The Purchaser shall select the representative, if any, of the underwriters to be
engaged in connection with any such registration,  subject to the consent of the
Company, which shall not unreasonably be withheld or delayed.

     Section  II.2.  Piggyback  Rights.  (a) If at any  time the  Company  shall
propose  to  register  any of its shares  for sale or  disposition,  for its own
account for cash under the 1933 Act in a Qualified  Public Offering  (including,
for this purpose, a registration  effected by the Company for stockholders other
than  Purchaser) and if all of the  Securities  have not been  registered  under
Section 2.01 above, the Company shall:

                  (i) Promptly  give to the Purchaser at least thirty (30) days'
         written notice prior to the filing  thereof  (which shall  include,  if
         then determined,  the proposed date on which the registration statement
         is to be filed,  the proposed price and  registration  price per share,
         the number of shares proposed to be included in such registration,  the
         identity  of  any  proposed  selling  stockholders  and a  list  of the
         jurisdictions  in which the Company  intends to attempt to qualify such
         securities  under the  applicable  blue sky or other  state  securities
         laws); and

                  (ii)   Include   in  such   registration   (and  any   related
         qualification  under  blue sky laws or  other  compliance),  and in any
         underwriting  involved  therein,  a portion of the Securities which are
         specified  in a written  request,  or requests,  made by the  Purchaser
         within ten (10) days  after  receipt of such  written  notice  from the
         Company by the Purchaser.


     (b) The rights of the  Purchaser to  registration  pursuant to this section
shall be conditioned  upon the  Purchaser's  participation  in any  underwriting
relating to the  Company's  registered  public  offering.  The  Purchaser  shall
(together  with the Company) enter into an  underwriting  agreement in customary
form with the underwriter or underwriters  selected by the Company.  The Company
will use its best efforts to include the Purchaser's Securities in the Qualified
Public  Offering.   Notwithstanding  any  provision  of  this  section,  if  the
underwriter, in its sole discretion, determines that marketing factors require a
limitation of the number of securities to be underwritten, or that the Qualified
Public  Offering  be  limited  to  shares  offered  by  the  Company  only,  the
underwriter  may  exclude  some or all of the  Purchaser's  shares for which the
Purchaser   seeks   registration   from  inclusion  in  the   registration   and
underwriting,  which  reduction  shall be pro rata among the  Purchaser  and any
other stockholder whose shares are sought to be included in the public offering.

     Section II.3. Termination of Registration Rights. The Company shall have no
obligation  under Section 2.01 or 2.02 to register any Securities if the Company
shall deliver to the holders  requesting such registration an opinion of counsel
reasonably satisfactory to such holders and their counsel to the effect that the
proposed sale or  disposition  for which  registration  was  requested  does not
require  registration under the 1933 Act. The Company hereby agrees to indemnify
the holders of Securities,  and each of them, against, and to hold them harmless
from, all damages,  losses,  liabilities  (including  liability for rescission),
costs and expenses that they may incur under the 1933 Act or otherwise by reason
of their proceeding in accordance with such opinion of counsel.

     Section  II.4.  Actions to be Taken by the  Company.  If and  whenever  the
Company  is  obligated  by the  provisions  of  this  Agreement  to  effect  the
registration of any offering of Securities  under the 1933 Act, as expeditiously
as possible the Company  will,  or will use its best efforts to, as the case may
be:

     (a) Prepare and file with the  Commission  a  registration  statement  with
respect to such  Securities  and cause  such  registration  statement  to become
effective;  provided,  however,  that before filing a registration  statement or
prospectus or any amendments or supplements  thereto,  the Company shall furnish
to the holders of the Securities covered by such registration  statement,  their
counsel and the  representative of the underwriters,  if any, copies of all such
documents proposed to be filed, which documents will be subject to the review of
such holders, their counsel and the representative of the underwriters,  if any,
and the Company shall not file any  registration  statement or prospectus or any
amendments  or  supplements  thereto to which the  holders of a majority  of the
Securities  covered  by  such  registration  statement,  their  counsel,  or the
representative of the underwriters,  if any, shall reasonably object on a timely
basis.

     (b) Prepare and file with the Commission such amendments and supplements to
such registration  statement and the prospectus used in connection  therewith as
may be necessary to keep such registration statement effective until the earlier
of the sale of all Securities  covered  thereby or the expiration of a period of
270 days after its effective  date,  and comply with the  provisions of the 1933
Act  with  respect  to  the  disposition  of  all  Securities  covered  by  such
registration statement; provided, however, that if maintaining the effectiveness
of the  registration  statement  would  require  the filing of a  post-effective
amendment  including new financial  statements (other than financial  statements
which the Company would be required to include in a current  report on Form 10-Q
under  Section  13 or 15(d) of the 1934  Act)  the  Company  shall be  obligated
hereunder  to  use  its  best  efforts  to  maintain  the  effectiveness  of the
registration statement for 90 days. In the event that any Securities included in
a  registration  statement  subject to, or required  by, this  Agreement  remain
unsold at the end of the period during which the Company is obligated to use its
best efforts to maintain the effectiveness of such registration  statement,  the
Company,  if and when a further  amendment  or  supplement  would be required to
comply with Section 10 of the 1933 Act, may file a  post-effective  amendment to
the  registration  statement  for the  purpose  of  removing  such  shares  from
registered status.

     (c)  Furnish to holders for whom  Securities  are  registered  or are to be
registered so many copies of a prospectus,  including a preliminary  prospectus,
in conformity with the  requirements of the 1933 Act, and such other  documents,
as such holders may reasonably request.

     (d)  Register  or  qualify  the  Securities  covered  by such  registration
statement under such other securities or blue sky laws of such  jurisdictions as
the holders for whom Securities are registered shall request, and do any and all
other acts and things that may be  reasonably  necessary  or advisable to enable
such  holders  to  consummate  the  disposition  in such  jurisdictions  of such
Securities;  provided,  however,  that the Company  shall not be  obligated,  by
reason thereof,  to qualify as a foreign corporation or file any general consent
to service of process under the laws of any such  jurisdiction or subject itself
to taxation as doing business in any such jurisdiction.

     (e) Notify the  holders for whom  Securities  are  registered  or are to be
registered  and their counsel  promptly  after the Company shall receive  notice
that any registration  statement,  supplement or amendment has become effective,
any  registration  statement is required to be amended or  supplemented,  or any
stop order with respect thereto has been issued.

     (f) Enter into such  agreements  (including  an  underwriting  agreement in
form,  scope and substance as is customary in  underwritten  offerings) and take
all such other  actions in  connection  therewith  (including  those  reasonably
requested by the representative of the underwriters or the holders of a majority
of the Securities subject to the registration statement) in order to expedite or
facilitate the  disposition of the Securities and in such  connection,  (i) make
such  representations  and  warranties to the  underwriters  with respect to the
business of the Company and its subsidiaries,  the registration  statement,  the
prospectus and the documents,  if any, incorporated or deemed to be incorporated
by reference in the registration  statement, in each case in form, substance and
scope  as are  customarily  made by  issuers  to  underwriters  in  underwritten
secondary  offerings  and  confirm the same if and when  requested;  (ii) obtain
opinions  of counsel to the  Company  and  updates  thereof,  which  counsel and
opinions (in form, scope and substance) shall be reasonably  satisfactory to the
representative  of the  underwriters,  addressed  to each  of the  underwriters,
covering the matters  customarily  covered in opinions requested in underwritten
offerings  and  such  other  matters  as may be  reasonably  requested  by  such
underwriters,  including without  limitation,  the matters referred to in clause
(i) above;  (iii) obtain  "cold  comfort"  letters and updates  thereof from the
independent certified public accountants of the Company (and, if necessary,  any
other independent  certified public accountants of any subsidiary of the Company
or of any business  acquired by the Company for which  financial  statements and
financial data is or is required to be included in the  registration  statement)
addressed to each of the underwriters,  such letters to be in customary form and
covering  matters of the type  customarily  covered in "cold comfort" letters to
underwriters in connection with  underwritten  offerings;  and (iv) deliver such
documents  and  certificates  as may be requested by the  representative  of the
underwriters  to evidence  the  continued  validity of the  representations  and
warranties made pursuant to clause (i) above and to evidence compliance with any
customary conditions contained in the underwriting  agreement or other agreement
entered into by the Company.  The above shall be done at each closing under such
underwriting or similar agreement, or as and to the extent required thereunder.

     (g) Make  available for inspection by any  underwriter  and any attorney or
accountant  retained  by such  underwriter,  all  financial  and other  records,
pertinent   corporate   documents   and   properties  of  the  Company  and  its
Subsidiaries, and cause the officers, directors and employees of the Company and
its  Subsidiaries  to supply all  information  reasonably  requested by any such
underwriter,  attorney  or  accountant  in  connection  with  such  registration
statement;  provided,  however, that any records,  information or documents that
are  designated  by the  Company  in  writing  as  confidential  shall  be  kept
confidential by such Persons unless (i) disclosure of such records,  information
or documents is required by court or administrative order, or (ii) disclosure of
such  records,  information  or  documents,  in the  opinion  of counsel to such
Person,  is  required by law  (including,  without  limitation,  pursuant to the
requirements  of the 1933 Act) or (iii) such records,  information  or documents
are in the public domain or otherwise publicly available.

     Section  II.5.  Costs and  Expenses.  The costs and  expenses  (other  than
underwriting  discounts  or  commissions  and such fees for  counsel,  printing,
registration and other fees as state  securities  officials may require that the
holders of Securities pay) of all  registrations  and  qualifications  under the
1933 Act,  and of all other  actions  that the  Company is  required  to take or
effect  pursuant to this  Agreement,  shall be paid by the  Company  (including,
without limitation,  all registration and filing fees, printing expenses,  costs
of special  audits  incident to or required by any such  registration,  fees and
disbursements  of  counsel  for  the  Company  and up to  $20,000  of  fees  and
disbursements  of one special counsel acting for the holders of Securities being
included in any  registration)  except that all such expenses in connection with
any amendment or supplement to the registration statement or the prospectus used
in connection  therewith  required to be filed more than 270 days after the date
on which  such  registration  statement  becomes  effective  under  the 1933 Act
because any holder has not effected the  disposition  of  Securities  covered by
such  registration  statement  shall be borne pro rata by such holder or holders
and  provided  that all such costs and  expenses  shall be borne pro rata by the
Company and all holders if required by any state  securities  commissioner  as a
condition to qualification of securities in such jurisdiction.

     Section II.6.  Indemnification.  In the event of any registration under the
1933 Act of any offering of  Securities,  the Company hereby agrees to indemnify
and hold harmless each holder of Securities  and each other Person,  if any, who
controls such holder  (within the meaning of the 1933 Act) and each other Person
(including each  underwriter,  and each other Person,  if any, who controls such
underwriter)  who  participates in the offering of such  Securities  against any
losses,  claims, damages or liabilities  ("Losses"),  joint or several, to which
such holder or  controlling  Person or  participating  Person may become subject
under the 1933 Act or  otherwise,  insofar  as such  Losses (or  proceedings  in
respect  thereof)  arise out of or are based  upon (a) any untrue  statement  or
alleged untrue  statement of any material fact contained,  on the effective date
thereof,  in any  registration  statement under which Securities were registered
under the 1933 Act, in any preliminary  prospectus or final prospectus contained
therein, or in any amendment or supplement thereto,  (b) the omission or alleged
omission  to state  therein a material  fact  required  to be stated  therein or
necessary to make the statements  therein not misleading or (c) any violation or
alleged  violation  by the  Company  of the 1933 Act,  the 1934  Act,  any state
securities  law or any rule or  regulation  promulgated  under the 1933 Act, the
1934 Act or any state  securities  law, and will  reimburse such holder and each
such controlling Person or participating  Person for any legal or other expenses
reasonably  incurred by such holder or such controlling  Person or participating
Person in connection  with  investigating  or defending any such Loss;  provided
that the Company will not be liable in any such case to the extent that any such
Loss  arises  out of or is based  upon an untrue  statement  or  alleged  untrue
statement or omission or alleged omission made in such  registration  statement,
such preliminary or final prospectus or such amendment or supplement in reliance
upon and in conformity with written information  furnished by an instrument duly
executed by such holder or such controlling or participating Person, as the case
may be, specifically for use in the preparation  thereof. The Company shall also
indemnify  underwriters  participating  in  the  distribution,  their  officers,
directors,  agents and  employees  and each  Person who  controls  such  Persons
(within the meaning of Section 15 of the 1933 Act or Section 20 of the  Exchange
Act) to the same extent as provided above with respect to the indemnification of
the holders of Securities.

     Section II.7. Additional Indemnification.  In the event of any registration
under the 1933 Act of any offering of Securities, each holder of such Securities
hereby severally  agrees to indemnify and hold harmless the Company,  each other
holder and each other  Person,  if any,  who  controls  the  Company  within the
meaning of the 1933 Act and each other Person (including each  underwriter,  and
each other Person,  if any, who controls such  underwriter)  who participates in
the offering of such Securities against any Losses,  joint or several,  to which
the  Company,  such holder or  controlling  Person or  participating  Person may
become  subject  under the 1933 Act or  otherwise,  insofar  as such  Losses (or
proceedings  in respect  thereof)  arise out of or are based upon (a) any untrue
statement or alleged  untrue  statement of any material fact  contained,  on the
effective date thereof, in any registration statement under which an offering of
such Securities was registered under the 1933 Act, in any preliminary prospectus
or  final  prospectus  contained  therein,  or in any  amendment  or  supplement
thereto,  (b) the omission or alleged  omission to state therein a material fact
required to be stated  therein or  necessary to make the  statement  therein not
misleading  or (c) any  violation or alleged  violation by the  Purchaser of the
1933 Act,  the 1934  Act,  any state  securities  law or any rule or  regulation
promulgated  under the 1933 Act, the 1934 Act or any state  securities  law, and
will  reimburse  the Company,  such holder and each such  controlling  Person or
participating  Person for any legal or other expenses reasonably incurred by the
Company,  such holder or such controlling or participating  Person in connection
with investigating or defending any such Loss or proceeding;  provided that such
holder  will be liable in any such case to the  extent,  and only to the extent,
that any such Loss arises out of or is based upon an untrue statement or alleged
untrue  statement  or omission  or alleged  omission  made in such  registration
statement,  such preliminary or final prospectus or such amendment or supplement
in reliance  upon and in  conformity  with written  information  furnished in an
instrument duly executed by such holder  specifically for use in the preparation
thereof.  The Company shall be entitled to receive indemnities from underwriters
participating  in the  distribution  to the same extent as  provided  above with
respect to information so furnished in writing by such Persons  specifically for
inclusion in any registration statement or prospectus.


     Section  II.8.  Indemnification  Procedures.  If any  action or  proceeding
(including any  governmental  investigation  or inquiry) shall be brought or any
claim shall be asserted  against any Person entitled to indemnity  hereunder (an
"indemnified  party"),  such  indemnified  party shall promptly notify the party
from which such indemnity is sought (the "indemnifying  party") in writing,  and
the indemnifying  party shall assume and control the defense thereof,  including
the employment of counsel  reasonably  satisfactory to the indemnified party and
the payment of all fees and  expenses  incurred in  connection  with the defense
thereof.  Any such fees and expenses borne by the indemnified  party  (including
any fees and expenses incurred in connection with  investigating or preparing to
defend such action or proceeding)  shall be paid to the  indemnified  party,  as
incurred,  within 15 days of written  notice thereof to the  indemnifying  party
(regardless of whether it is ultimately  determined that an indemnified party is
not entitled to indemnification hereunder;  provided the indemnified party shall
reimburse  such  fees  and  expenses  if  it is  finally  determined  that  such
indemnified party is not entitled to indemnity hereunder).  Any such indemnified
party shall have the right to employ separate counsel in any such action,  claim
or  proceeding  and to  participate  in the  defense  thereof,  but the fees and
expenses of such counsel shall be the expenses of such indemnified  party unless
(a) the indemnifying party has agreed to pay such fees and expenses,  or (b) the
indemnifying  party  shall have  failed to assume  promptly  the defense of such
action, claim or proceeding,  or (c) the named parties to any such action, claim
or proceeding  (including any impleaded  parties)  include both such indemnified
party and the indemnifying  party,  and such  indemnified  party shall have been
advised by counsel that there may be one or more legal defenses  available to it
which are different from or in addition to those  available to the  indemnifying
party  and that the  assertion  of such  defenses  would  create a  conflict  of
interest  such  that  counsel  employed  by  the  indemnified  party  could  not
faithfully  represent the indemnified  party (in which case, if such indemnified
party  notifies  the  indemnifying  party in  writing  that it  elects to employ
separate  counsel at the expense of the  indemnifying  party,  the  indemnifying
party  shall not have the right to assume the defense of such  action,  claim or
proceeding on behalf of such indemnified  party; it being  understood,  however,
that the  indemnifying  party shall not, in connection with any one such action,
claim or proceeding or separate but  substantially  similar or related  actions,
claims or proceedings in the same  jurisdiction  arising out of the same general
allegations or circumstances,  be liable for the reasonable fees and expenses of
more than one  separate  firm of  attorneys  (together  with  appropriate  local
counsel) at any time for all such indemnified parties,  unless in the reasonable
judgment of such indemnified party a conflict of interest may exist between such
indemnified party and any other of such indemnified parties with respect to such
action,  claim or  proceeding,  in which event the  indemnifying  party shall be
obligated to pay the fees and expenses of such additional  counsel or counsels).
The indemnifying party shall not be liable for any settlement of any such action
or proceeding effected without its written consent.



     Section II.9.  Contribution.  If the  indemnification  provided for in this
Agreement is  unavailable  to an  indemnified  party under  Section 2.06 or 2.07
(other than by reason of  exceptions  provided in those  Sections) in respect of
any Losses, then each applicable indemnifying party in lieu of indemnifying such
indemnified  party  shall  contribute  to the  amount  paid or  payable  by such
indemnified  party  as a  result  of  such  Losses,  in  such  proportion  as is
appropriate  to  reflect  the  relative  fault  of the  indemnifying  party  and
indemnified  parties in  connection  with the actions,  statements  or omissions
which  resulted  in  such  Losses  as  well  as  any  other  relevant  equitable
considerations.   The  relative  fault  of  such  indemnifying   party  and  the
indemnified  party shall be  determined  by reference  to,  among other  things,
whether any action in question, including any untrue statement or alleged untrue
statement of a material fact or omission or alleged omission of a material fact,
has  been  taken  or made  by,  or  relates  to  information  suppled  by,  such
indemnifying  party or  indemnified  party,  and the parties'  relative  intent,
knowledge,  access to  information  and  opportunity  to correct or prevent such
action, statement or omission. The amount paid or payable by a party as a result
of any Losses shall be deemed to include,  subject to the  limitations set forth
in this Section 2.09, any legal or other fees or expenses reasonably incurred by
such  party in  connection  with  any  action,  suit,  claim,  investigation  or
proceeding. No Person guilty of fraudulent misrepresentation (within the meaning
of Section  11(f) of the 1933 Act) shall be  entitled to  contribution  from any
Person who was not guilty of such fraudulent misrepresentation.

     Section II.10. Form S-3. The Company  represents and warrants that it meets
the  requirements  for the use of Form S-3 for  registration  of the sale by the
Purchaser of the Securities,  and the Company shall file all reports required to
be filed by the Company with the SEC in a timely  manner so as to maintain  such
eligibility for the use of Form S-3.


                                   ARTICLE III

                                  Miscellaneous

     Section  III.1.  APPLICABLE  LAW.  THIS  AGREEMENT  AND ALL RIGHTS  ARISING
HEREUNDER  SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE
STATE OF NEW YORK  APPLICABLE  TO CONTRACTS  MADE AND TO BE  PERFORMED  ENTIRELY
WITHIN SUCH STATE.

     Section  III.2.  WAIVER OF JURY.  THE COMPANY AND THE PURCHASER EACH HEREBY
WAIVES  TRIAL  BY  JURY  IN  ANY  JUDICIAL  PROCEEDING  INVOLVING,  DIRECTLY  OR
INDIRECTLY,  ANY MATTER (WHETHER SOUNDING IN TORT, CONTRACT OR OTHERWISE) IN ANY
WAY ARISING OUT OF,  RELATED TO, OR CONNECTED  WITH THIS AGREEMENT AND ANY RIGHT
ARISING HEREUNDER.


     Section III.3.  Jurisdiction and Venue; Service of Process. (a) The Company
and  the  Purchaser  each  hereby  irrevocably   submits  to  the  non-exclusive
jurisdiction of any state or federal court in the Borough of Manhattan, The City
of New York for the purpose of any suit, action, proceeding or judgment relating
to or arising out of this Agreement and any right arising hereunder,  and to the
laying of venue in the Borough of Manhattan,  The City of New York.  The Company
and  the  Purchaser  each  hereby  irrevocably  waives,  to the  fullest  extent
permitted by  applicable  law,  any  objection to the laying of the venue of any
such  suit,  action or  proceeding  brought in the  aforesaid  courts and hereby
irrevocably waives any claim that any such suit, action or proceeding brought in
any such court has been brought in an inconvenient forum.

     (b) The  Company  agrees  that  service of  process  in any such  action or
proceeding  may be effected by mailing a copy thereof by registered or certified
mail (or any  substantially  similar  form of  mail),  postage  prepaid,  to the
Company at its  address  set forth in Section  3.06 or at such other  address of
which the  Purchaser  shall have been  notified  pursuant  thereto.  The Company
further  agrees that nothing  herein shall affect the right to effect service of
process in any other manner permitted by law or shall limit the right to sue any
other jurisdiction.

     (c) Each of the Purchaser and the Company waives, to the maximum extent not
prohibited by law, any right it may have to claim or recover in any legal action
or proceeding referred to in this Section 3.03 any special, exemplary,  punitive
or  consequential  damages.  The waiver set forth in this Section  3.03(c) shall
terminate  automatically upon the occurrence of a "Separation Event", as defined
in that certain  stockholder rights protection plan of Pharmacia & Upjohn,  Inc.
in effect on the date of this Agreement, as it may from time to time be amended.

                     Section III.4. Amendments and Waivers.

     (a) Any provision of this Agreement may be amended, modified,  supplemented
or waived,  but only by a written  amendment or supplement,  or written  waiver,
signed by the Company and the Purchaser.

     (b) Except to the extent  expressly set forth therein,  any waiver shall be
effective only in the specific  instance and for the specific  purpose for which
such waiver is given.

     Section III.5.  Cumulative Rights; No Waiver.  Each and every right granted
to the Purchaser or allowed the Purchaser by law or equity,  shall be cumulative
and not exclusive and may be exercised from time to time. No failure on the part
of the Purchaser to exercise, and no delay in exercising, any right will operate
as a waiver thereof, nor will any single or partial exercise by the Purchaser of
any right preclude any other or future  exercise  thereof or the exercise of any
other right.

     Section III.6. Notices. (a) Any communication, demand or notice to be given
hereunder will be duly given when delivered in writing or by telecopy to a party
at its  address  as  indicated  below or such  other  address  as such party may
specify in a notice to each  other  party  hereto.  A  communication,  demand or
notice given pursuant to this Section 3.06 shall be addressed:

     If to the Company, to

                           Miravant Medical Technologies
                           7408 Hollister Avenue
                           Santa Barbara, California 93117

                           Telecopy:  (805) 685-6038

                           Attention:  Gary S. Kledzik

     with a copy (which, in and of itself, shall not constitute notice) to

                           Nida & Maloney PC
                           800 Anacapa Street
                           Santa Barbara, California 93101

                           Telecopy:         (805) 568-1955

                           Attention:  Joseph E. Nida

     and

                           Wilson Sonsini Goodrich & Rosati
                           650 Page Mill Road
                           Palo Alto, California 94304

                           Telecopy:  (650) 493-6811

                           Attention:  John T. Sheridan

     If to the Purchaser, to

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:  (908) 470-8047

                           Attention:  Treasurer

     and

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:  (908) 306-4485

                           Attention:  Senior Vice President
                                       of Business Development

     and

                           Pharmacia & Upjohn, Inc.
                           95 Corporate Drive
                           Bridgewater, New Jersey 08807

                           Telecopy:  (908) 306-4489

                           Attention:  General Counsel

     with a copy (which, in and of itself, shall not constitute notice) to

                           Sullivan & Cromwell
                           125 Broad Street
                           New York, New York 10004

                           Telecopy:        (212) 558-3588

                           Attention: Neil T. Anderson,
                                             Matthew G. Hurd
                                             and Martin J. Travers


     (b) Unless otherwise  provided to the contrary herein,  any notice which is
required to be given in writing  pursuant to the terms of this  Agreement may be
given by telecopy.

     Section  III.7.  Separability.  In case  any one or more of the  provisions
contained in this Agreement shall be invalid,  illegal or  unenforceable  in any
respect  under  any  law,  the  validity,  legality  and  enforceability  of the
remaining  provisions  contained  in  this  Agreement  shall  not in any  way be
affected or impaired thereby.

     Section III.8.  Persons  Benefitting.  This Agreement shall be binding upon
and inure to the benefit of the Purchaser and the Company,  and their respective
successors,  assigns,  beneficiaries,  executors and administrators.  Nothing in
this  Agreement  is  intended or shall be  construed  to confer upon any Person,
other  than  the  Company  and the  Purchaser  (and  such  successors,  assigns,
beneficiaries,  executors and administrators),  any right, remedy or claim under
or by reason of this  Agreement or any part hereof.  This  Agreement  may not be
assigned  without the written consent of the parties  hereto,  and any purported
assignment  made in  violation  of this  provision  shall be null and void.  The
provisions of the previous  sentence  notwithstanding,  the Purchaser may assign
its rights and  obligations  under this  letter  agreement  to any of its wholly
owned subsidiaries without the consent of the Company.

     Section III.9.  Counterparts.  This Agreement may be executed in any number
of  counterparts,  each of which shall be deemed an  original,  but all of which
together constitute one and the same instrument.

     Section III.10.  Headings. The descriptive headings of the several Sections
of this Agreement are inserted for  convenience  and shall not control or affect
the meaning or construction of any of the provisions hereof.

     Section III.11. Remedies. In the event of a breach by the Company or by the
Purchaser of any of their obligations under this Agreement, the Purchaser or the
Company,  as the case may be, in  addition to being  entitled  to  exercise  all
rights  granted by law,  including  recovery  of  damages,  will be  entitled to
specific  performance  of its rights under this  Agreement.  The Company and the
Purchaser agree that monetary damages would not be adequate compensation for any
loss  incurred  by  reason of a breach  by it of any of the  provisions  of this
Agreement  and  hereby  further  agrees  that,  in the event of any  action  for
specific  performance in respect of such breach, it shall waive the defense that
a remedy at law would be adequate.


     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed, as of the date first above written.


                    MIRAVANT MEDICAL TECHNOLOGIES


                    By:________________________________
                    Name:
                    Title:


                    PHARMACIA & UPJOHN, INC.


                    By:________________________________
                    Name:
                    Title:










                       AMENDED AND RESTATED OPHTHALMOLOGY
                         DEVELOPMENT & LICENSE AGREEMENT



                                     between



                              PHARMACIA & UPJOHN AB



                                       and



                          MIRAVANT MEDICAL TECHNOLOGIES


                                    o , 1999


                              AMENDED and RESTATED

                 OPHTHALMOLOGY DEVELOPMENT AND LICENSE AGREEMENT

     THIS AMENDED and RESTATED  OPHTHALMOLOGY  DEVELOPMENT AND LICENSE AGREEMENT
(the  "Agreement")  is made  and  entered  into as of o,  1999,  by and  between
PHARMACIA  & UPJOHN  AB, a  company  organized  and  existing  under the laws of
Sweden,   (hereinafter   referred  to  as  "P&U  AB"),   and  MIRAVANT   MEDICAL
TECHNOLOGIES, INC., a company organized and existing under the laws of the State
of Delaware,  with its head offices at 7408  Hollister  Avenue,  Santa  Barbara,
California 93117, U.S.A. (hereinafter referred to as "Miravant").

                                WITNESSETH THAT:

     WHEREAS,  on 8 June  1998,  P&U AB and  Miravant  entered  an  Amended  and
Restated  Development and License Agreement for the field of ophthalmology  (the
"1998 AB License Agreement"); and

     WHEREAS,  P&U AB and Miravant desire to amend the 1998 AB License Agreement
to provide  for the  transfer  to P&U AB of  certain  clinical,  regulatory  and
manufacturing  responsibilities  with  respect to the  Development  Program  (as
defined  herein)  and to modify  inter alia the rights  and  obligations  of the
parties accordingly;

     NOW,  THEREFORE,  in  consideration of the above premises and the covenants
contained  herein,  the  parties  hereby  amend and  restate the 1998 AB License
Agreement in its entirety as follows, effective as of the date hereof:


                             ARTICLE 1 - DEFINITIONS



The  following  capitalized  terms used herein shall have the meanings set forth
below:

     1.1 Affiliate. "Affiliate" shall mean, with respect to any specified party,
any  person  or  entity  that  directly  or  indirectly   through  one  or  more
intermediaries,  controls, or is controlled by, or is under common control with,
the party specified.  For purposes of this definition,  "Control" including with
correlative meanings,  the terms "controlled by" and "under common control with"
means  ownership  directly or indirectly of more than fifty percent (50%) of the
equity  capital  having the right to vote for election of  directors  (or in the
case  of  an  entity  other  than  a  corporation,   the  equivalent  management
authority).

     1.2 Agreement. "Agreement" shall mean this Amended and Restated Development
and License Agreement.

     1.3 Aggregate Borrowings.  "Aggregate  Borrowings" shall mean the aggregate
principal amount of Quarterly Loans made pursuant to the Credit Agreement, dated
as of January o, 1999, between P&U AB and Miravant, without giving effect to any
repayments or prepayments thereof.

     1.4 Clinical  Tests.  "Clinical  Tests" shall mean any tests,  performed on
humans in preparation and support of regulatory submissions.

     1.5 Development Program. "Development Program" shall mean the program to be
conducted by Miravant and P&U AB to develop Product (as hereinafter defined) and
obtain  regulatory  approvals  for the  sale of  Product  in the  Territory  (as
hereinafter defined) in accordance with the provisions of Article 4 hereof.

     1.6 Effective Date. The term "Effective  Date" shall mean the date on which
this Agreement has been duly executed by both parties.

     1.7 FDA. "FDA" shall mean the United States Food and Drug Administration or
the equivalent  governmental  authority in any other  country,  or any successor
agency having the administrative  authority to regulate the approval for testing
or marketing of human  pharmaceutical  or  biological  medical  products  and/or
medical devices.

     1.8 Field. "Field" shall mean the field of Ophthalmology, including for the
avoidance of doubt all current and future indications in the Field.

     1.9 Gross Sales.  "Gross Sales" shall mean the final gross  invoiced  price
from the sale of Product by P&U AB and its Affiliates or Sublicensees; provided,
that Gross Sales shall exclude sales of Product  intended for resale between P&U
AB and its Affiliates and Sublicensees. Gross Sales from the sale of the Product
in Eastern Europe,  the Middle East,  Africa and Central America by Sublicensees
which are not  Affiliates  of P&U AB shall be  measured  by the F.O.B.  invoiced
price from P&U AB or one of its Affiliates to such distributors.

     1.10 GCP. "GCP" shall mean current "good  clinical  practices" for carrying
out clinical  studies in humans as set forth in  regulations  promulgated by the
FDA,  as such may be  amended  from  time to time  or,  where  appropriate,  the
equivalent regulations  promulgated by the equivalent  governmental authority in
any other country.

     1.11  GLP.  "GLP"  shall  mean  current  "good  laboratory  practices"  for
conducting  nonclinical  laboratory  studies as set forth in regulations (21 CFR
Part 58)  promulgated  by the FDA, as such may be amended  from time to time or,
where  appropriate,  the  equivalent  regulations  promulgated by the equivalent
governmental authority in any other country.

     1.12 GMP. "GMP" shall mean current "good  manufacturing  practices" for the
preparation of drug products as set forth in  regulations  (21 CFR Parts 210 and
211)  promulgated by the FDA, as such may be amended from time to time, or where
appropriate,   the   equivalent   regulations   promulgated  by  the  equivalent
governmental authority in any other country.

     1.13 IND. "IND" shall mean all governmental  approvals required to commence
clinical testing in humans,  including an "investigational new drug application"
submitted to the FDA under 21 CFR ss.312 for the purpose of conducting  clinical
investigations of Product or the equivalent in any other country.

     1.14  Light  Devices.  "Light  Devices"  shall  mean the  instruments  that
produce, deliver or measure light for use with Product.

     1.15 *****
     ***** Confidential Treatment Requested

     1.16 Major Indication. "Major Indication" shall mean the indications in the
Field as set forth in Schedule 1.16.

     1.17 Minor Indication. "Minor Indication" shall mean the indications in the
Field as set forth in Schedule 1.17.

     1.18 Net Sales.  "Net  Sales"  shall mean Gross  Sales less the  following:
trade,  cash  and  quantity   discounts;   returns,   normal  trade  allowances,
charge-backs,  federal,  state, or other  governmental  rebates and adjustments;
taxes on the sale or transportation of the Products absorbed by P&U AB.

     1.19 *****
     ***** Confidential Treatment Requested

     1.20 NDA.  "NDA" shall mean all  approvals  (including,  where  applicable,
pricing and  reimbursement)  to sell a  pharmaceutical  product in any  country,
including a "New Drug Application" or other premarket  approval  application for
Product,  and  any  supplement  or  abbreviated  application  relating  thereto,
submitted to the FDA or the equivalent in any other country.

     1.21 Other Indications.  "Other  Indications" shall mean the indications in
the Field set forth in Schedule 1.21. 

     1.22  Out-of-Pocket  Expenses.  "Out-of Pocket  Expenses" shall mean actual
expenses,  including expenses for outside  consultants and CRO's, in relation to
Product paid after the  Effective  Date by Miravant or its  Affiliates  to third
parties who are not Affiliates of Miravant.

     1.23 Patent Rights. "Patent Rights" shall mean all patent applications,  as
well as continuation,  divisional or continuation-in-part  applications, and all
patents  issuing   therefrom,   including  reissue  or  reexamination   patents,
containing at least one claim covering Product, its use or sale, and only to the
extent such Patent  Rights are  directed to Product,  which are now or hereafter
owned or acquired by Miravant or any of its Affiliates,  or licensed to Miravant
or any of its  Affiliates,  and  all  extensions  and  supplementary  protection
certificates  relating thereto.  Patent Rights licensed to Miravant will only be
granted to P&U AB to the extent  permitted by Miravant's  license  agreement and
P&U AB will do nothing to disturb such agreement.

     1.24 Photodynamic Therapy.  "Photodynamic Therapy" shall mean the technique
of  diagnosis  and/or  treatment  of  abnormal or normal  biological  or medical
conditions, either in-vivo or ex-vivo, through the use of drugs activated by any
type of electromagnetic radiation or magnetic field.

     1.25 Preclinical Tests.  "Preclinical  Tests" shall mean any nonhuman tests
performed in preparation and support of regulatory submissions.

     1.26 Product. "Product" shall mean pharmaceutical products for Photodynamic
Therapy  containing tin ethyl  etiopurpurin as the active drug substance and any
isomers and derivatives thereof, in any formulation, for use in the Field.

     1.27  Project  Team.  "Project  Team"  shall have the  meaning set forth in
Section 4.4.

     1.28 SnET2.  "SnET2" shall mean the Photodynamic Therapy drug designated by
Miravant as tin ethyl etiopurpurin in any formulation or strength for use in the
Field.

     1.29 Steering  Committee.  "Steering  Committee" shall have the meaning set
forth in Section 4.2.

     1.30 Sublicensee.  "Sublicensee" shall mean a third party to whom P&U AB or
any of its Affiliates  has granted,  in whole or in part, the right to market or
comarket the Product in one or more  countries in the Territory and who performs
selling  activities such as invoicing  customers in one or more countries in the
Territory.

     1.31  Technology.   "Technology"  shall  mean  all  information  and  data,
including,  but not limited to,  technical,  pharmacological,  toxicological and
clinical  information,   know-how,  inventions  and  improvements  possessed  by
Miravant as of the  Effective  Date or generated or obtained by Miravant  during
the term of this Agreement  relating to the  registration,  manufacture,  use or
sale of Product,  in each case to the extent  Miravant  has the right to provide
the same to P&U AB hereunder;  provided, that "Technology" shall not include any
such  information  or data  regarding  the  design or  manufacture  of any Light
Device.

     1.32 Territory. "Territory" shall mean the entire world.

     1.33  Unit.  "Unit"  shall  mean *****
     ***** Confidential Treatment Requested

     1.34  Schedules.  The  Schedules  which are attached to this  Agreement and
which are herein incorporated, are as follows: 

                  Schedule          Description

                  1.16                               Major Indications
                  1.17                               Minor Indications
                  1.21                               Other Indications
                  3.3                                Key Countries



                        ARTICLE 2 - INTENTIONALLY OMITTED



                     ARTICLE 3 - LICENSE GRANT AND ROYALTIES

     3.1 License. Subject to the terms of this Agreement, Miravant hereby grants
to P&U AB and P&U  AB's  Affiliates  an  exclusive  worldwide,  royalty-bearing,
license under the Patent  Rights and the  Technology,  not to mean  devices,  to
manufacture or have manufactured, use, distribute and sell Product for diagnosis
or treatment in the Field in the Territory. P&U AB may sublicense, totally or in
part, the license rights granted under this Section 3.1; provided,  that (i) P&U
AB must notify  Miravant in writing of any such  sublicense at least thirty (30)
days in advance; (ii) P&U AB remains responsible to Miravant for all contractual
obligations  of the  Sublicensee,  including,  but not  limited  to,  payment of
royalties,  keeping of records and reporting of sales,  as if the  Sublicensee's
sales were P&U AB's sales;  and (iii) the Sublicensee  agrees to be bound by the
terms of this Agreement to the same extent as P&U AB to the extent applicable to
the Sublicensee.

     3.2 Term of License.  With respect to Product,  the license  rights granted
under  Section 3.1 shall remain in effect in each country in the  Territory  for
the  duration  of the  Patent  Rights or for a period of ten (10) years from the
first commercial sale of Product on a country-by-country  basis, whichever shall
be longer.  After this period, P&U AB shall have an irrevocable,  fully paid-up,
nonexclusive license under the Technology in such country.

     3.3 Milestone Payments.  For Major and Minor Indications,  P&U AB shall pay
Miravant only the following sums upon achievement of the stated milestones:

     (i) if,  after  conducting  ***** for any Major and Minor  Indication,  the
Steering  Committee decides to proceed with ***** for such indication *****, P&U
AB shall pay Miravant: ***** for each Major Indication; and ***** for each Minor
Indication;  provided,  that  in the  event  *****  are  not  required  for  any
indication  and the Steering  Committee  decides to proceed  with *****,  P&U AB
shall not owe Miravant a ***** milestone payment for each such indication;

     ***** Confidential Treatment Requested

     (ii) for each  Major and Minor  Indication,  at the ***** in one or more of
the Key Countries  listed in Schedule  3.3, P&U AB shall pay Miravant  ***** for
each  Major  Indication  so  approved,  and ***** for each Minor  Indication  so
approved.

     ***** Confidential Treatment Requested

     (iii) P&U AB shall not owe Miravant any milestone payments for ***** or for
Other Indications (as defined in Section 1.21).

     ***** Confidential Treatment Requested


     3.4 Royalties.

     (i) P&U AB shall, for the term of the license specified by Section 3.2, pay
Miravant royalties on Net Sales of such Products to third parties at the rate of
***** on total Net Sales of Product of ***** per calendar year, and a royalty of
***** on the part of total Net Sales of such Products ***** per calendar year.

     ***** Confidential Treatment Requested

     (ii) *****

     ***** Confidential Treatment Requested

     3.5  Sublicense  Fees.  P&U AB shall pay Miravant  ***** of any up-front or
lump-sum fees received by P&U AB in  consideration  of the grant of a sublicense
to Product, other than to an Affiliate.

     ***** Confidential Treatment Requested

     3.6 Payment of Milestone Payments and Out-of- Pocket Expenses.  All amounts
of money due  pursuant  to  Section  3.4 and for the  payment  of  Out-of-Pocket
Expenses  described  in Article 4 shall be paid to  Miravant  or its  designated
Affiliate  within  thirty  (30)  days  from  receipt  by P&U AB of the  relevant
Miravant invoice.

     3.7 Payment of  Royalties.  The royalties due pursuant to Section 3.4 shall
be reported quarterly within thirty (30) days after March 31, June 30, September
30 and December 31. Such  royalties  shall be paid to Miravant or its designated
Affiliate quarterly within sixty (60) days after March 31, June 30, September 30
and December 31. Each payment to Miravant or its designated  Affiliate  shall be
accompanied by a report containing sufficient  information to enable Miravant or
its designated  Affiliate to verify the accuracy of the calculation of Net Sales
on which such payment was based during the payment period, including a statement
of Gross Sales and Net Sales and a  reconciliation  of the credits,  allowances,
rebates and other deductions contemplated by Section 1.14 to calculate Net Sales
from Gross Sales.

     3.8 Payment of  Royalties,  Fees,  and  Expenses.  The  milestone  payments
specified by Section 3.3 herein shall be paid to Miravant in US dollars. For the
purpose  of  converting  and  paying  royalties,   Out-of-Pocket   Expenses  and
sublicense fees specified by Section 3.5 herein,  monies shall be first computed
in the  currency  of the  country  where the sales took place or the expense was
incurred, and then, unless another currency is designated by Miravant, converted
into US dollars at the most favorable  buying  exchange rates  prevailing on the
day P&U AB converts the local currency into US dollars for payment to Miravant.

     3.9 P&U AB  Ceases to Market or Sell  Product.  Unless  otherwise  mutually
agreed to by the parties and provided that a particular Product is sold or is to
be sold in a Major  Country by one entity only, be it P&U AB or its Affiliate or
a Sublicensee,  should P&U AB or its Affiliates or Sublicensees  cease to market
or sell a Product in that Major  Country or fail to launch a particular  Product
in that Major Country within ***** from the occurrence of the latest to occur of
the  following  events (if  applicable in such Major  Country):  (i) issuance of
Product's NDA approval in that country, (ii) governmental price approval,  (iii)
reimbursement  of the social  security  (if any),  and (iv) NDA  approval of all
relevant  Light  Devices,  P&U AB shall have no further rights to the Product in
that  country nor shall P&U AB have any further  obligations  for the Product in
that country, except such obligations which accrued prior to divestment from P&U
AB of rights to the Product.  In the event rights to a Product are divested from
P&U AB in any country pursuant to this Section 3.9 and upon Miravant's  request,
P&U AB shall  immediately  transfer  the NDA approval and IND in that country to
Miravant or to an  appointee  of  Miravant,  provide to Miravant all data in P&U
AB's  possession  or control  relating  to that  Product and take all such other
actions  as are  necessary  or useful to permit  Miravant  to obtain  regulatory
approvals to market Product in such country.  If P&U AB fails to comply with the
foregoing within thirty (30) business days after such Miravant  request,  P&U AB
hereby  irrevocably  appoints  Miravant  as its  attorney-in-fact  to secure the
transfer of the NDA  approval  and IND to  Miravant.  Miravant  shall market the
Product under its own tradenames or brands and shall not use P&U AB's tradenames
or brands. Failure by P&U AB to launch a Product or interruption of marketing or
sale of a Product  pursuant to this Section 3.9 shall not be considered a breach
of this Agreement  within the meaning of Article 10. For the avoidance of doubt,
it is understood  between the parties  hereto that the provision of this Section
3.9 shall not apply in the event that P&U AB or its  Affiliates or  Sublicensees
cease to sell a  Product  or fail to  launch a Product  in a Major  Country  for
reasons related to the safety and efficacy of a Product.

     ***** Confidential Treatment Requested

     3.10 Books and Records.  P&U AB shall keep,  and shall cause its Affiliates
and  Sublicensees  to keep,  complete and  accurate  books of accounts and other
records,  for a period of ***** from the relevant  sale,  containing  sufficient
detail as may be  necessary  for Miravant to properly  ascertain  and verify the
royalties  payable  to  it  hereunder  in  accordance  with  generally  accepted
accounting  principles.   Upon  Miravant's  request,  P&U  AB  shall  permit  an
independent certified accountant selected by Miravant (except one to whom P&U AB
has some  reasonable  objection)  to have access once each year during  ordinary
business  hours to such P&U AB  records as may be  necessary  to  determine  the
correctness  of any report and payment made under this  Agreement.  If the audit
shows that P&U AB has underpaid any royalties by ten percent (10%) or more,  for
any period  covered by the  audit,  P&U AB shall,  in  addition  to  immediately
remitting  to  Miravant  the  amount of  underpayment,  pay for the cost of such
audit.  In the event the audit shows that P&U AB has overpaid any  royalties due
pursuant  to Section  3.4,  P&U AB shall be allowed to deduct the amount of such
overpayment from the next semiannual royalty payment due to Miravant.

     ***** Confidential Treatment Requested


               ARTICLE 4 - STRATEGIC PLAN, DEVELOPMENT AND FUNDING

     4.1 Strategic  Plan. The parties shall develop a written plan in respect to
the Field of  Ophthalmology,  by March 31,  1999.  This plan shall be called the
"Strategic Plan".

     4.2 Steering Committee.  The direction and activities to be conducted under
the Strategic Plan are under the oversight of a Steering Committee consisting of
***** members. The *****. Each of the parties shall have***** representatives on
the Steering  Committee.  Responsibilities  of the Steering  Committee  shall be
limited to  recommendation  of additions and deletions to the indications to the
Strategic  Plan,  amendment and approval of the  Development  Program  including
schedules  and  budgets.  If  the  Steering  Committee  recommends  to  add  any
indication  not  identified  in  Schedules  1.16,  1.17 or 1.21,  it shall  also
determine whether it is a Major,  Minor or Other  Indication,  based on criteria
including  but not limited to,  ***** and *****.  Any addition or deletion of an
indication shall be made by the parties as an amendment of this Agreement.  Each
party may replace any of its respective members without the consent of the other
party.

     ***** Confidential Treatment Requested

     4.3 Voting.  Each member of the Steering  Committee shall have one (1) vote
and all decisions of the Steering Committee shall require a majority vote. *****

     ***** Confidential Treatment Requested

     4.4 Project Team. The details of the planning and conduct of the activities
under the  Strategic  Plan shall be  supervised  by a Project Team (the "Project
Team").  The  membership  of the  Project  Team  shall  be  chosen  by P&U AB in
consultation  with  Miravant  and shall  contain up to four  representatives  of
Miravant.

     4.5 Reporting of Results. Within ten (10) days after March 31 and September
30 of each  year,  each  party  shall  provide  the other  party with a detailed
progress  report  on  its  implementation  of  the  Strategic  Plan,   including
experimental results and Phase I, Phase II and Phase III Clinical Test data. The
parties shall also consult  periodically  and at such times as determined by the
Steering Committee

     4.6 *****

     ***** Confidential Treatment Requested

     4.7 SnET2 for  Ophthalmology.  Unless  otherwise  determined by the Project
Team, P&U AB shall be responsible  for conducting all necessary  Preclinical and
Clinical  Tests  for  SnET2  to be used in any  indications  in the  Field.  The
Out-of-Pocket  Expenses  associated  with  Preclinical  and Clinical Tests being
conducted  by  Miravant  on  the  Effective   Date,  or  conducted  by  Miravant
thereafter,  shall be  reimbursed by P&U AB;  provided,  that these studies were
conducted in accordance  with the  protocols and budget  approved by the Project
Team and Steering  Committee.  P&U AB shall be  responsible  for  conducting all
post-NDA approval studies which may be necessary. The Steering Committee has the
right to determine,  in its reasonable judgment,  whether to proceed to Clinical
Tests for any indication in the Field.  All Clinical Tests shall be conducted in
accordance  with the  protocols  approved by the Project  Team.  Miravant  shall
supply  to P&U AB SnET2  and Light  Devices  to enable  P&U AB to carry out such
Tests  conducted by it. The actual costs of SnET2 and Light Devices for all Test
phases shall be shared equally by the parties hereto.

     4.8 Submission of NDA. P&U AB shall be  responsible  for assembling the NDA
for a Product  and to  submit  it to the  concerned  health  authorities  of the
Territory.  All such NDAs  shall be filed in the name of,  and shall  remain the
sole and exclusive property of, P&U AB, subject to Section 3.9 hereof. Before an
NDA is submitted to the concerned health  authorities,  it shall be reviewed and
approved by the Steering  Committee.  Following the submission of the NDA to the
concerned  health  authorities,  P&U AB will  prosecute  such NDA  diligently in
accordance with the time schedule set forth in the Strategic Plan.

     4.9 Audit of  Out-of-Pocket  Expenses.  Miravant  shall keep,  or cause its
Affiliates to keep,  complete and accurate records of Out-of-Pocket  Expenses in
sufficient detail for P&U AB to verify the accuracy of any invoices submitted to
P&U AB by Miravant  for payment of  Out-of-Pocket  Expenses  pursuant to Section
4.7. P&U AB shall have the right to audit such records on an annual basis, using
an independent certified  accountant,  at a date and time acceptable to Miravant
during normal business hours. If as a result of the audit, it is determined that
P&U AB has been  overcharged by Miravant during a calendar year by more than ten
percent  (10%) of the actual  expenses,  Miravant  shall pay for the cost of the
audit,  and P&U AB shall,  at its  discretion,  either  deduct the amount of the
overcharge  from the next  semiannual  royalty  payment or take a credit against
payment of future invoices for Out-of-Pocket Expenses.



                        ARTICLE 5 - DUTIES OF THE PARTIES

     5.1 Promotion and Customer Service.  As Miravant's  exclusive  licensee for
Product  in the  Territory,  P&U AB  agrees  to use all  reasonable  efforts  to
introduce,  promote,  market  and sell  Product in the  Territory.  P&U AB shall
maintain adequate  facilities,  Product inventory and personnel to ensure prompt
handling and  servicing of customers'  inquiries and orders and prompt  shipment
and servicing of Product.

     5.2 Care of Product.  P&U AB shall  comply with all  applicable  regulatory
requirements  regarding acceptable methods for the care,  handling,  storage and
shipment of Product.  Each party hereby agrees that it shall promptly provide to
the other,  on  request,  all  information  known to it which is  necessary  for
compliance  with  the  applicable  laws and  regulations  concerning  the  care,
handling, storage, labeling, packaging and shipment of Product.

     5.3 Exclusive.  During the term of this Agreement,  unless otherwise agreed
to by Miravant, P&U AB shall not, directly, or indirectly, develop or sell other
Photodynamic  Therapy  drugs for use in the Field.  P&U AB agrees  that it shall
secure the same agreement from its Affiliates and Sublicensees.

     5.4  Authorization.  P&U AB and Miravant each warrant that it has the legal
capacity to enter into this  Agreement  and that it has  secured  all  necessary
approvals.

     5.5  Obligations to Miravant's  Licensor.  To the extent relating to Patent
Rights or  Products in the Field,  P&U AB agrees to  undertake  all  sublicensee
obligations  set  forth in any  license  agreement  between  Miravant  and third
parties which was fully disclosed to P&U AB on or prior to July 10, 1996.

     5.6 Sale of Product by  Miravant.  Subject to the terms of this  Agreement,
while the license granted to P&U AB under Article III hereof with respect to any
Product is in effect in any country in the Territory, Miravant shall not license
or appoint any other licensee, distributor or marketing representative in or for
such country for such  Product in the Field,  sell such Product in or for use in
such country,  nor accept orders for such Product from purchasers located within
such  country or from any  purchasers  Miravant  has reason to believe will sell
such Product within or for use in such country except as provided for in Section
3.9.

     5.7 Right to License Patent Rights, Product and Technology. Miravant hereby
represents  and warrants  that it owns or has rights to use the  Technology  and
Patent Rights described  herein,  and that it has the right to grant sublicenses
under any license to SnET2 or covering Product held by Miravant.

     5.8 Access to Information Relating to Light Devices.  Both parties agree to
provide the other with access to  information  or data relating to Light Devices
which either  party may need for  regulatory  approval to market  Product in the
Field and which  Miravant may need for  regulatory  purposes for products  other
than Product in the Field.

     5.9 Access to Light  Devices.  The  parties  mutually  acknowledge  that an
essential  feature of the  development  of Product for  marketing  hereunder  is
access by P&U AB to Light Devices.  Miravant  agrees that it shall undertake all
necessary action (i) to enable P&U AB to enter a supply  relationship  among P&U
AB,  Miravant and Iridex  Corporation for the supply of the Light Devices to P&U
AB and its  Affiliates  or  Sublicensees  and  (ii) to  insure  that  P&U AB has
continued  access  to  Light  Devices  during  the  term of the  license  rights
specified by Section 3.2.

     5.10  Compliance  with  Applicable  Law.  In  exercising  the rights and in
carrying out the duties and obligations set forth in this Agreement,  each party
represents and warrants that it shall comply with all applicable state,  federal
and country laws or rules.  Each party further  represents  and warrants that it
shall  comply  with  all  applicable   rules  and   regulations   governing  the
manufacture,  distribution,  promotion,  marketing  and sale of  Product  in the
Territory  and that it shall  specifically  comply with GLP's,  GCP's,  GMP's or
other  equivalent  regulatory  requirements  of any  country.  Unless  otherwise
disclosed,  Miravant  represents  and warrants  that all studies which were done
prior to the  Effective  Date and  which are  included  in the IND or NDA for KS
and/or BCC have been conducted in accordance with GLP's,  GCP's, and GMP's where
applicable.

     5.11  Duty  to  Develop  Product.  Each  party  agrees  that it  shall  use
reasonable  efforts  to  develop  Product  in the Field in  accordance  with the
Strategic Plan.

     5.12 Patent Filing,  Prosecution and Maintenance;  Trademarks. (i) Miravant
shall be responsible for all decisions relating to and all costs associated with
preparing,  filing,  prosecuting and maintaining  Patent Rights.  Miravant shall
timely  notify P&U AB about  each  patent  application  filed  which  relates to
Product,  its progress and subsequent  disposition and consult with P&U AB prior
to taking any significant  action with respect to Patent Rights.  Miravant shall
not voluntarily abandon or forfeit any Patent Rights, without the prior approval
of P&U AB, such approval shall not be unreasonably withheld or delayed. (ii) P&U
AB shall own all trademarks, logos and/or trade dress which it registers for use
or otherwise uses in connection with the Product.

     5.13 Miravant's  Representations.  Miravant hereby  represents and warrants
that:

     (i) It is not party to any agreement, arrangement or understanding with any
third party which in any material way conflicts  with its ability to fulfill any
of its obligations under this Agreement.

     (ii) It will not knowingly  commit any material act or fail to take any act
which would cause a material  omission or permit any acts or  omissions to occur
which would be in conflict with its obligations under this Agreement or diminish
in any  material  respect the  potential  scope of the grant of rights to P&U AB
under this Agreement.

     (iii) It has no knowledge  that the license  rights  granted to P&U AB with
respect to the Product shall not be subject to any material  retained  rights of
any state, federal or foreign government or governmental entity,  except for the
rights of the United  States  government  under the  Bayh-Dole Act and except as
disclosed to P&U AB prior to July 10, 1996.

     (iv) It has no knowledge that making,  using or selling any Products (alone
or in combination  with any Light Devices) may infringe the patent rights of any
third party nor does it have any  knowledge  that any third party is  infringing
the Patent Rights.

     (v) It has no  agreement,  understanding  or  undertaking,  with any  third
parties  regarding  the  ownership  or  disposition  of tin ethyl  etiopurpurin,
isomers and derivatives thereof or any Product.

     5.14  Complaints.  Miravant and P&U AB shall share with each other all data
on complaints in respect of Product subject to this Agreement including, but not
limited to,  complaints or information  regarding  performance or allegations or
reports of any effects on a patient  from use of such  Product,  as soon as such
data is available. To the extent that it has knowledge thereof, each party shall
promptly  notify the other in writing of any defect in, or condition of, Product
subject  to this  Agreement  which may cause any such  Product  to  violate  the
applicable  laws and  regulations  of any  country in the  Territory  where such
Product is being sold by P&U AB.

     5.15 Recall.  In the event of a total or partial  recall of Product sold by
Miravant to P&U AB under this Agreement,  whether  voluntary or mandated by law,
the parties  agree to  cooperate  fully to effect the recall.  In the event such
recall  results from the gross  negligence  or willful  misconduct  of Miravant,
Miravant shall bear all the expenses  associated with such recall.  In the event
such recall results from the gross  negligence or willful  misconduct of P&U AB,
P&U AB shall bear all the expenses  associated  with such recall.  If any recall
results  without gross  negligence or willful  misconduct of either party,  then
Miravant  and P&U AB shall  equally  bear the  expenses of such  recall.  P&U AB
agrees to maintain  adequate sales and service records to enable it to carry out
any Product recall and to conduct such recall.

     5.16 Adverse  Reactions.  Each party shall be responsible  for  maintaining
such records and making such reports as may be required in  connection  with any
regulatory  approval held by the party. Each party shall immediately  inform the
other of all adverse drug experience  reports and other information  relating to
the safety or effectiveness of product which come to its attention.



                     ARTICLE 6 - *****

     ***** Confidential Treatment Requested



                   ARTICLE 7 - PUBLICATION AND CONFIDENTIALITY

     7.1  Publication.  At least thirty (30) days prior to the time either party
submits any data or articles related to Product or Technology for publication or
presentation,  the  proposed  publication  or  presentation  must be sent to the
Project  Team for review and  clearance.  If the Project  Team so decides,  such
publication or  presentation  can be delayed as long as necessary to preserve US
or foreign patent or other property rights.

     7.2  Disclosure.  Miravant  shall  disclose to P&U AB from time to time all
information relating to the Patent Rights,  Technology and Product for the Field
which was not  previously  disclosed;  provided,  that  Miravant  shall  only be
required to disclose  such  information  to P&U AB as is necessary for P&U AB to
fulfill its obligations under this Agreement.  All information  disclosed by one
party  to the  other  under  this  Section  7.2  shall be  deemed  "Confidential
Information"  and  treated as  provided  in  Section  7.3  hereof.  P&U AB shall
disclose to Miravant, or Miravant shall have access to, information developed by
P&U AB related to Product  including,  but not  limited  to, the NDA's and other
regulatory data including clinical data and investigators' reports, applications
and licenses.

     7.3 Confidential  Information.  Unless otherwise  mutually agreed to by the
parties,   the  parties  agree  to  maintain  in  confidence  all   Confidential
Information disclosed to the other pursuant to Section 7.2 and shall not, during
the term of this  Agreement and for a period of five (5) years  thereafter,  use
such Confidential Information, except as permitted by this Agreement or disclose
the same to anyone  other  than  those of its  officers,  directors,  employees,
Affiliates and  Sublicensees to the extent  necessary in connections with either
party's  activities as contemplated in this Agreement.  Each party shall use its
reasonable efforts to ensure that its officers, directors, employees, Affiliates
and  Sublicensees  do  not  disclose  or  make  any  unauthorized  use  of  such
Confidential Information.

     7.4  Limitations  on  Confidentiality.  The  obligation of  confidentiality
contained  in  Section  7.3 shall not  apply to the  extent  that (i) a party is
required  to  disclose  information  by  applicable  law,  such as  pursuant  to
Securities  and  Exchange  Commission  rules  and  regulations,  or  order  of a
governmental  agency  or a court of  competent  jurisdiction,  (ii) a party  can
demonstrate  that the  disclosed  information  was,  at the time of  disclosure,
already in the public domain other than as a result of actions or failure to act
of a party, its officers, directors,  employees,  Affiliates and Sublicensees in
violation  hereof;  (iii) the disclosed  information  was rightfully  known by a
party or its Affiliates or sublicensees  (as shown by its written records) prior
to the date of disclosure to the other party in connection  with this Agreement;
or (iv) the disclosed  information  was received by a party or its Affiliates or
Sublicensees on an unrestricted basis from a third party source which is not the
other  party  or an  Affiliate  of the  other  party  and  not  under  a duty of
confidentiality, and which was rightfully known to said source.



                        ARTICLE 8 - TERM AND TERMINATION

     8.1 Term.  Subject to the  provisions  of this  Article 8, the term of this
Agreement  shall  continue so long as P&U AB shall be obligated to pay royalties
on the sale of any Product in the Territory.

     8.2  Termination  for Breach.  In the event either  party shall  materially
breach any of the terms,  conditions and agreements contained herein to be kept,
observed and performed by it, then the other party may terminate this Agreement,
at its option and  without  prejudice  to any of its other  legal and  equitable
rights and remedies,  by giving the party which  committed the breach sixty (60)
days' notice of its intent to  terminate,  particularly  specifying  the breach,
unless the notified party within such 60 day period shall have cured the breach.
The 60 day period  shall be extended for a period not  exceeding  an  additional
ninety (90) days for breaches which cannot be reasonably cured within the 60 day
period if the party has commenced to cure the breach within that period.

     8.3  Termination  by  Bankruptcy.  In the event  either  party shall file a
voluntary petition or any answer admitting the jurisdiction of the Court and the
material  allegations of, or shall consent to, an involuntary  petition pursuant
to or purporting to be pursuant to any  reorganization  or insolvency law of any
jurisdiction, or shall make an assignment of substantially all of its assets for
the benefit of creditors,  or shall apply for or consent to the appointment of a
receiver or trustee of a substantial part of its property (such party,  upon the
occurrence of any such event, a "Bankrupt Party"),  then to the extent permitted
by law  the  other  party  hereto  may  thereafter  immediately  terminate  this
Agreement by giving  notice of  termination  to the Bankrupt  Party,  unless the
proceeding is dismissed within ninety (90) days of its filing.

     8.4 Effect of Termination. It is understood and agreed that the termination
of this  Agreement  shall not affect the rights or  obligations  of the  parties
which (i) by the terms hereof, continue after the termination of this Agreement,
or (ii) have accrued prior to such  termination  including,  but not limited to,
the  rights of  Miravant  to  receive  any  amounts  then  owing from P&U AB for
royalties  due  hereunder,  all of which amounts  shall be  immediately  due and
payable on such date.



                         ARTICLE 9 - PATENT INFRINGEMENT

     9.1  Infringement by Third Parties.  If, during the term of this Agreement,
either Miravant or P&U AB shall acquire  knowledge or have  reasonable  cause to
believe  that  any of the  Patent  Rights  claiming  a  Product,  or its  use or
manufacture,  shall be  infringed  or used  without  authorization  by any other
person in the  Territory,  such party  shall  promptly  notify the other of such
knowledge.  Miravant and P&U AB shall  promptly  meet to discuss the  commercial
impact of such third party  infringement  and the most efficient and expeditious
manner to proceed against said third party.

     9.2 Initiation of Action by Miravant or P&U AB. Miravant may take all steps
in its name which are necessary or advisable including,  without limitation, the
institution  of any action or  proceeding  for the  obtaining  of damages or the
enjoinment  of any such  infringement  and to prosecute,  settle,  compromise or
otherwise  dispose of the same.  Miravant shall be entitled to the full recovery
of any money or other property collected by way of judgment, settlement (whether
prior to or after the  institution  of any action or proceeding) or otherwise on
any action  initiated by Miravant.  If Miravant does not commence such an action
within one  hundred  eighty  (180) days after a request to do so by P&U AB, then
P&U AB may initiate an action or proceeding  for the obtaining of damages or the
enjoinment  of any such  infringement  and to prosecute,  settle,  compromise or
otherwise  dispose of the same. P&U AB shall be entitled to the full recovery of
any money or other property  collected by way of judgment,  settlement  (whether
prior to or after the  institution  of any action or proceeding) or otherwise on
any action  initiated by P&U AB. Each party agrees to reasonably  cooperate with
the other  party in any legal  proceeding  and to pay all of its own costs taken
pursuant to this Section 9.2.

     9.3  Claims  Against  P&U AB or  Miravant.  If any  claim is made or action
brought against P&U AB or Miravant based on the claim that P&U AB or Miravant is
infringing  any third party patent rights by virtue of the  manufacture,  use or
sale of Product  hereunder,  P&U AB or  Miravant  shall  promptly  so notify the
other.  The parties shall then consult with each other as to the most  efficient
and reasonable course of action to take relative to such third party claim. Each
party hereto shall pay its own expenses in defending any such third party claim.
P&U AB shall solely be responsible for any trademark infringement claims and for
all damages claimed against P&U AB and its Affiliates by any third party.

     9.4  Damages  Paid to Third  Party.  If, in any such  action  described  in
Section  9.3,  a court  of  competent  jurisdiction  determines  that  P&U AB or
Miravant is obligated to pay damages to any third  person  (excluding  trademark
claims) because P&U AB or Miravant's  manufacture,  use or sale of a Product was
held to be an  infringement  of a third party right,  *****.

     ***** Confidential Treatment Requested

     9.5 Reduction of Royalties. In the event the legal proceedings described in
Section 9.3 result in a settlement  or other final action which  requires P&U AB
to pay a royalty to a third party in order to  continue to use or sell  Product,
the royalty paid by P&U AB to Miravant  for such Product  shall be reduced by an
amount  equal to ***** of the rate of the royalty that P&U AB is required to pay
to such third party,  not to exceed ***** of the royalties which would otherwise
be payable to Miravant.

     ***** Confidential Treatment Requested



                          ARTICLE 10 - INDEMNIFICATION

     10.1  Indemnification.  Except for matters relating to indemnification  for
infringement of intellectual property rights, as to which Article 9 shall be the
sole and exclusive provisions,  each party to this Agreement shall indemnify and
hold the other party hereto harmless from and against any and all action, causes
of action, claims, demands, suits, controversies,  damages, verdicts, judgments,
executions and all cost and expenses in connection therewith including,  but not
limited to, reasonable  attorneys' fees,  whether or not well founded in fact or
in law, brought or claimed by any third persons, which and to the extent thereof
shall arise from any breach of this  Agreement by, or from the negligent acts or
omissions of, the indemnifying party under this Agreement (a "Liability").

     10.2 Notice of Defense of Actions.  Each party shall give the other  prompt
notice  of any  potential  Liability,  and  promptly  after  receipt  by a party
claiming  indemnification  under this Section 10.2 of notice of the commencement
of any action,  such indemnified party will notify the indemnifying party of the
commencement of the action and generally summarize such action. The indemnifying
party shall have the right to  participate  in and to assume the defense of such
action with counsel of its choosing.  An  indemnifying  party shall not have the
right to direct the defense of such an action of an indemnified party if counsel
to such  indemnified  party has reasonably  concluded that there may be defenses
available to it that are different from or additional to those  available to the
indemnifying party;  provided,  that in such event, the indemnifying party shall
bear the fees and expenses of separate  counsel  reasonably  satisfactory to the
indemnifying  party. The failure to notify an indemnifying party promptly of the
commencement  of any such action,  if  prejudicial to the ability to defend such
action,   shall  relieve  such  indemnifying  party  of  any  liability  to  the
indemnified  party under this  Section  10.2,  but the omission so to notify the
indemnifying  party will not relieve such party of any liability that such party
may  have to any  indemnified  party  otherwise  than  under  this  Section.  No
settlement  of any  claim or  action  may be made  without  the  consent  of the
indemnifying party (which shall not be unreasonably withheld or delayed).



                       ARTICLE 11 - RESOLUTION OF DISPUTES

     11.1 Resolution of Disputes by Parties'  Presidents.  The parties recognize
that a bona fide  dispute  as to  certain  matters  may from time to time  arise
during  the term of this  Agreement  which  relate to either  party's  rights or
obligations hereunder.  In the event of the occurrence of such a dispute, either
party may, by written notice to the other,  have such dispute  referred to their
respective  officer   designated  below  or  their  successors,   for  attempted
resolution by good faith  negotiations  within sixty (60) days after such notice
is received. Said designated officers are as follows:

         For Miravant - President

         For P&U AB- Managing Director or his designate

         In the event  the  designated  officers  are not able to  resolve  such
dispute  within such sixty (60) day period,  any party may invoke the provisions
in Section 11.2 below,  other than for matters  within the scope of the Steering
Committee.

     11.2 Arbitration. Except as expressly provided in Section 11.1, any and all
disputes  arising out of or in connection with the performance of this Agreement
shall be finally  settled by  arbitration  in  accordance  with the rules of the
American  Arbitration  Association,  except  that each party will be entitled to
select one (1) arbitrator and the two (2) arbitrators so selected shall select a
third  arbitrator and if they cannot agree,  then the third arbitrator who shall
not be a citizen of the  United  States or of Sweden,  will be  selected  by the
American Arbitration Association. The arbitration shall be held in New York, New
York. The award  rendered shall be final and binding upon the parties.  Judgment
on any award may be entered in any court having jurisdiction over the parties or
their assets.  To the extent any claims  relate to the  validity,  construction,
scope, enforceability or infringement of any Patent Rights, such claim shall not
be required to be submitted to arbitration  hereunder and shall be resolved by a
court of  competent  jurisdiction.  The  costs of  arbitration  shall be  shared
equally by the parties.



                           ARTICLE 12 - MISCELLANEOUS

     12.1 Force  Majeure.  Neither P&U AB nor Miravant shall be in default under
this Agreement nor liable for any failure to perform or for delay in performance
resulting from any cause beyond its reasonable control or due to compliance with
any  regulations,  order or act of any federal,  provincial,  state or municipal
government,  or any department or agency thereof,  civil or military  authority,
acts of God, fires, floods or weather;  strikes or lockouts;  factory shutdowns,
embargoes, wars, hostilities or riots.

     12.2 Taxes.  Each of the parties  hereto shall be  responsible  for its own
taxes imposed as a result of the  performance by such party under this Agreement
including,  but not  restricted to, any sales tax, any tax on or measured by any
royalty or other payment  required to be made by it hereunder,  any registration
tax,  any tax imposed with respect to the granting of or transfer of licenses or
other rights hereunder or the payment or receipt of royalties hereunder. For the
avoidance  of any  doubt,  it is agreed  that any  withholding  tax  levied on a
payment  required  to  be  made  pursuant  to  this  Agreement,   shall  be  the
responsibility of the party receiving such payment.  The parties shall cooperate
fully with each other in obtaining  and filing all  requisite  certificates  and
documents with the  appropriate  authorities and shall use their best efforts to
take such further  action as may  reasonably be necessary to avoid the deduction
of any  withholding  or similar taxes from any  remittance of funds by P&U AB to
Miravant hereunder; provided, that P&U AB may withhold any tax it is required to
collect or pay on behalf of Miravant.

     12.3  Notices.  All notices,  proposals,  submissions,  offers,  approvals,
agreements, elections, consents, acceptances, waivers, reports, plans, requests,
instructions and other communications  required or permitted to be made or given
hereunder  (all  of  the  foregoing  hereinafter  collectively  referred  to  as
"Communications")  shall be in writing,  in the English  language,  and shall be
deemed  to have  been  duly made or given  when (i)  delivered  personally  with
receipt acknowledged,  (ii) mailed in any post office,  enclosed in a registered
or certified  postage-paid  envelope,  return receipt  requested,  (iii) sent by
facsimile,  telex or cablegram  (which shall  promptly be confirmed by a writing
sent by registered or certified mail, return receipt  requested) or (iv) sent by
a recognized  courier (e.g. DHL, Federal Express,  etc.), in each case addressed
or sent to the parties at the following  addresses  and facsimile  numbers or to
such  other or  additional  address  or  facsimile  number  as any  party  shall
hereafter specify by Communication to the other party:


         P&U AB:                    Pharmacia & Upjohn AB
                                                     Lindhagensgatan 133
                                                     S-112 87  STOCKHOLM
                                                     SWEDEN
                                            Attention: Associate General Counsel
                                                     Fax: +46 8 695 47 08

         With a copy to:            Pharmacia & Upjohn, Inc.
                                                     95 Corporate Drive
                                                     Bridgewater, NJ 08807
                                                     Fax # 908-306-4489
                           Attention: General Counsel

         Miravant:                                   Miravant, Inc.
                                                     7408 Hollister Avenue
                                                     Santa Barbara, CA  93117
                                                     U.S.A.
                                                     Attn: President
                                                     Fax # 805-685-2959

         With a copy to:            Nida & Maloney, P.C.
                                                     800 Anacapa Street
                                                     Santa Barbara, CA  93101
                                                     U.S.A.
                                                     Attn: Joseph E. Nida
                                                     Fax # 805-568-1955

Notice of a change of address shall be deemed given when actually received.  All
other Communications  shall be deemed to have been given,  received and dated on
the  earlier  of:  (i) when  actually  received  or on the date  when  delivered
personally or (ii) one (1) day after being sent by facsimile, cable, telex (each
promptly  confirmed by a writing as aforesaid) or courier and seven (7) business
days after mailing.

     12.4 Relationship.  The relationship  between the parties shall be governed
by the  terms of this  Agreement  and  shall  not  extend  to other  activities,
transactions  or  contracts.  Neither  party  hereto  is in any way  the  agent,
venturer of partner of the other party.

     12.5 Governing  Law. The provisions of this Agreement  shall be governed in
all  respects  by the laws of New  York  without  regard  to  conflicts  of laws
principles.

     12.6 Other  Instruments.  The parties  hereto  covenant and agree that they
will  execute  such other and further  instruments  and  documents as may become
reasonably necessary or convenient to effectuate and carry out the provisions of
this Agreement or may be reasonably requested by the other party.

     12.7  Legal  Construction.  In  case  any  one or  more  of the  provisions
contained in this Agreement  shall be invalid or  unenforceable  in any respect,
the validity and  enforceability  of the remaining  provisions  contained herein
shall not in any way be  affected  or  impaired  thereby  and the  parties  will
attempt  to  agree  upon a valid  and  enforceable  provision  which  shall be a
reasonable  substitute for such invalid and unenforceable  provision in light of
the tenor of this  Agreement  and,  upon so  agreeing,  shall  incorporate  such
substitute provision in this Agreement.

     12.8 Entire Agreement,  Modification,  Consents and Waivers. This Agreement
contains the entire  agreement of the parties with respect to the subject matter
hereof and no interpretation,  change,  termination or waiver of or extension of
time for performance under any provision of this Agreement shall be binding upon
any  party,  unless in  writing  and  signed by the party  intended  to be bound
thereby.  Receipt  by any party of money or other  consideration  due under this
Agreement, with or without knowledge of breach, shall not constitute a waiver of
such breach or any provision of this Agreement.  Except as otherwise provided in
this  Agreement,  no waiver of or other  failure to exercise  any right under or
default  or  extension  of time for  performance  under  any  provision  of this
Agreement  shall affect the right of any party to exercise any subsequent  right
under any provision of this Agreement or otherwise enforce said provision or any
other  provision  hereof or to exercise  any right or remedy in the event of any
other default, whether or not similar.

     12.9  Agreements  Read as a Whole. It is the intent of the parties that the
terms of this  Agreement  and the  terms of any  other  agreements  between  the
parties  related to the Product and/or the Strategic Plan be read as a whole and
as being consistent with one another.  In the event of an inconsistency  between
the  terms  of  this  Agreement  and  any  of  such  other   agreements,   which
significantly impacts the parties' ability to carry out the Strategic Plan, such
inconsistency shall be resolved by the Steering Committee.

     12.10  Section  Headings;  Construction.  The section  headings  and titles
contained  herein are each for reference  only and shall not be deemed to affect
the meaning or interpretation of this Agreement.  The singular shall include the
plural,  the conjunctive  shall include the disjunctive and the masculine gender
shall  include  the  feminine  and neuter,  and vice  versa,  unless the context
otherwise requires.

     12.11  Amendment.  This  Agreement  may only be  amended  in  writing by an
agreement designated as an amendment and executed by the parties hereto.

     12.12  Survival.  Articles  7  and  10  shall  survive  the  expiration  or
termination of this Agreement.



                     ARTICLE 13 - BINDING EFFECT: ASSIGNMENT

     13.1  Binding  Effect and  Assignment.  This  Agreement  shall inure to the
benefit of and be binding upon each of the parties  hereto and their  respective
successors  and  assigns.  Neither  this  Agreement,  nor any of the  rights and
obligations  under this  Agreement,  may be assigned,  transferred  or otherwise
disposed of by either party without the prior consent of the other party, unless
such assignment,  transfer or disposition is to a successor to substantially all
the business or assets of the transferor;  provided,  that, such successor shall
in any event agree in writing with the other party to assume all  obligations of
the transferor under this Agreement in a manner satisfactory to the other party.
Subject to the foregoing  limitations,  the Agreement  shall be binding upon and
inure to the benefit of the respective successors and assigns of the parties.

     13.2 Right to Seek Assurance.  In the event all or substantially all of the
assets  of  either  P&U AB or  Miravant  are  acquired  by a  third  party,  the
non-acquired  party shall have the right  pursuant to Section  13.1 to receive a
written  assurance  from such  third  party  that the  third  party  intends  to
faithfully  perform all of the duties and  obligations of the acquired party set
forth in this Agreement.  The acquired party shall take all action  necessary to
enable the non-acquired party to obtain such written assurance.


     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
executed in duplicate by their respective  officer thereunder duly authorized as
of the date first hereinabove written.

MIRAVANT MEDICAL TECHNOLOGIES                       PHARMACIA & UPJOHN AB


By ________________________________                 By _________________________

Gary S. Kledzik, Chairman of the Board            Title: _______________________
 and Chief Executive Officer

                                                 By ____________________________

 




                                  SCHEDULE 1.16


                                Major Indications


                                      *****

     ***** Confidential Treatment Requested




                                  SCHEDULE 1.17


                                      *****


                                      *****


                                      *****


                                      *****
     ***** Confidential Treatment Requested


                                  SCHEDULE 1.21


                                Other Indications


                                      *****

     ***** Confidential Treatment Requested




                                  SCHEDULE 3.3


                                  Key Countries


                                      *****

                                      *****

                                      *****

                                      *****


                                      *****

                                      *****

     ***** Confidential Treatment Requested



                                   [Pharmacia & Upjohn, Inc. Letterhead]




                                                       January o, 1999


Miravant Medical Technologies
7408 Hollister Avenue
Santa Barbara, California  93117

Dear Sirs:

                  This letter will confirm our agreement as follows:

                  1.  In  the   event   that   Miravant   Medical   Technologies
("Miravant")  develops  SnET2 (as  defined in Section  1.28 of the  Amended  and
Restated  Development  &  License  Agreement,  of even  date  herewith,  between
Pharmacia & Upjohn AB and Miravant (the  "Ophthalmology  Agreement")) within the
field  of  cardiovascular  medicine  (the  "Field")  or  acquires  such  rights,
Pharmacia & Upjohn,  Inc.  ("P&U")  shall have a right of first  negotiation  to
acquire  exclusive  marketing  rights to SnET2 in the Field,  to the extent that
Miravant has a right to grant such rights. The parties contemplate  conducting a
feasibility evaluation concerning SnET2 in the Field. Thereafter, if the parties
hereto execute and deliver an agreement providing for additional development and
commercialization  of SnET2 in the Field, such agreement shall extend to P&U the
same right of first negotiation with respect to any photodynamic drugs developed
by  Miravant  for use in the Field as are  extended  to P&U in  respect of SnET2
pursuant to this letter agreement, subject to such termination provisions as the
parties may agree.  Miravant will provide P&U's General Counsel, at 95 Corporate
Drive,  Bridgewater,  New Jersey  08807 with  written  notice that  Miravant has
developed or acquired  SnET2 in the Field,  together  with the  preclinical  and
clinical data then available to Miravant,  or any other written notices required
herein.


                  2. *****

                  3. *****

                  4. *****

                  5. *****

     *****Confidential Treatment Requested


                  6. THIS  LETTER  AGREEMENT  AND ALL RIGHTS  ARISING  HEREUNDER
SHALL BE GOVERNED BY AND CONSTRUED IN  ACCORDANCE  WITH THE LAWS OF THE STATE OF
NEW YORK  APPLICABLE TO CONTRACTS MADE AND TO BE PERFORMED  ENTIRELY WITHIN SUCH
STATE.
                  7. This  letter  agreement  may be  executed  in any number of
counterparts,  each of  which  shall be  deemed  an  original,  but all of which
together constitute one and the same instrument.

                  8. This  letter  agreement  may not be  assigned  without  the
written  consent of the parties  hereto,  and any purported  assignment  made in
violation  of this  provision  shall be null and  void.  The  provisions  of the
previous  sentence  notwithstanding,  P&U may assign its rights and  obligations
under this letter agreement to any of its wholly owned subsidiaries  without the
consent of Miravant.

                                            Very truly Yours,



                                            PHARMACIA & UPJOHN, INC.


                         By:___________________________
                                      Name:
                                     Title:



Agreed and accepted as of the date hereof.

MIRAVANT MEDICAL TECHNOLOGIES


By:_______________________
   Name:
   Title:





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