PERCLOSE INC
SC 13G, 1999-02-17
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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<PAGE>
 
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549


                                  SCHEDULE 13G


                   Under the Securities Exchange Act of 1934
                            (Amendment No._______)*



                                 PERCLOSE, INC.
                                 --------------
                                (Name of Issuer)

                        Common Stock ($0.001 Par Value)
                        -------------------------------
                         (Title of Class of Securities)

                                   71361C107
                                   ---------
                                 (CUSIP Number)

Check the following box if a fee is being paid with this statement [ ].

(A fee is not required only if the filing person: (1) has a previous statement
on file reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such
class.)(See Rule 13d-7.)

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



                         (Continued on following pages)
                               Page 1 of 6 Pages
<PAGE>
 
CUSIP No. 71361C107                                      Page 2 of 6
- -------------------                                      -----------


1.  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        Brown Investment Advisory & Trust Company ("BIATC"), its wholly owned
        subsidiary, Brown Advisory Incorporated ("BAI").  52-1811121

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
        (a)  [_]
        (b)  [x]


3.  SEC USE ONLY

4.  CITIZENSHIP OR PLACE OF ORGANIZATION

     Brown Investment Advisory & Trust Company and Brown Advisory Incorporated
     are Maryland corporations.

NUMBER OF          5 SOLE VOTING POWER
SHARES             BIATC  170,084 shares
                   BAI    593,770 shares
                          -------   
                          763,854 shares

BENEFICIALLY       6 SHARED VOTING POWER
OWNED BY           BIATC        0 shares
                   BAI          0 shares
                          ------- 
                                0 shares


EACH REPORTING     7 SOLE DISPOSITIVE POWER
PERSON WITH        BIATC  190,984 shares
                   BAI    593,770 shares
                          -------
                          784,754 shares


                   8 SHARED DISPOSITIVE POWER
                   BIATC        0 shares
                   BAI          0 shares
                          -------
                                0 shares
<PAGE>
 
CUSIP No. 71361C107                                      Page 3 of 6
- -------------------                                      -----------

9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                    BIATC  190,984 shares
                    BAI    593,770 shares
                           -------     
                           784,754 shares

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*  
          [ ]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                    BIATC    1.8%
                    BAI      5.5%
                             ---   
                             7.3%

12.  TYPE OF REPORTING PERSON*

                    BIATC - BK
                    BAI   - IA

                      *SEE INSTRUCTIONS BEFORE FILLING OUT
                      ------------------------------------

Item 1. (a)  NAME OF ISSUER:   Perclose, Inc.

        (b)  Address of Issuer's Principal Executive Offices:

             199 Jefferson Drive, Menlo Park, CA 94025

Item 2. (a)  NAME OF PERSON FILING:

             Brown Investment Advisory & Trust Company ("BIATC"), its wholly
             owned subsidiary, Brown Advisory Incorporated ("BAI").

        (b)  ADDRESS OF PRINCIPAL BUSINESS OFFICE:
  
             19 South Street
             Baltimore, Maryland 21202

        (c)  CITIZENSHIP:

             Brown Investment Advisory & Trust Company and Brown Advisory
             Incorporated are Maryland corporations.
<PAGE>
 
CUSIP No. 71361C107                                      Page 4 of 6
- -------------------                                      -----------

    (d)  TITLE OF CLASS OF SECURITIES:

         Common Stock of ($0.001 Par Value) of Perclose, Inc.

    (e)  CUSIP Number:

         71361C107

Item 3.  If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b),
         check whether the person filing is a:

             For BIATC

         (b) [x] Bank as defined in section 3(a)(6) of the Act

             For BAI

         (e) [x] Investment Adviser registered under section 203 of the
             Investment Advisers Act of 1940

Item 4.  OWNERSHIP:

         (a)  AMOUNT BENEFICIALLY OWNED:    As of December 31, 1998

                    BIATC  190,984 shares
                    BAI    593,770 shares
                           -------     
                           784,754 shares

         (b)  PERCENT OF CLASS:

                    BIATC    1.8%
                    BAI      5.5%
                             ---   
                             7.3%

         (c)  Number of shares as to which such person has:

         (i) sole power to vote or to direct the vote:

                    BIATC  170,084 shares
                    BAI    593,770 shares
                           -------     
                           763,854 shares
<PAGE>
 
CUSIP No. 71361C107                                      Page 5 of 6
- -------------------                                      -----------
                                        
(ii) shared power to vote or to direct the vote:

               BIATC    0 shares
               BAI      0 shares
                     ----   
                        0 shares

(iii)  sole power to dispose or to direct the disposition of:

               BIATC  190,984 shares
               BAI    593,770 shares
                      -------  
                      784,754 shares

(iv) shared power to dispose or to direct the disposition of:

               BIATC    0 shares
               BAI      0 shares
                     ----   
                        0 shares

Item 5.   OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

            Not applicable

Item 6.   OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

            Not applicable

Item 7.   IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
          SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.

            Not applicable

Item 8.   IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

            Not applicable

Item 9.   NOTICE OF DISSOLUTION OF GROUP.

            Not applicable
<PAGE>
 
CUSIP No. 71361C107                                      Page 6 of 6
- -------------------                                      -----------

Item 10. CERTIFICATION.


       By signing below I certify that, to the best of my knowledge and belief,
       the securities referred to above were acquired in the ordinary course of
       business and were not acquired for the purpose of and do not have the
       effect of changing or influencing the control of the issuer of such
       securities and were not acquired in connection with or as a participant
       in any transaction having such purpose or effect.


       SIGNATURE:

       After reasonable inquiry and to the best of my knowledge and belief, I
       certify that the information set forth in this statement is true,
       complete and correct.

       Date:  As of December 31, 1998

       Signature:  Brown Investment Advisory & Trust Company

       By: /S/ Gregg W. Hawes
 
       Title:  Principal

       Signature:  Brown Advisory Incorporated

       By: /S/ Gregg W. Hawes

       Title:  Principal


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