ALLERGAN LIGAND RETINOID THERAPEUTICS INC
SC 13D/A, 1997-12-04
PHARMACEUTICAL PREPARATIONS
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                          UNITED STATES
                 SECURITIES AND EXCHANGE COMMISSION
                      Washington, D.C.  20549

                           SCHEDULE 13D

             Under the Securities Exchange Act of 1934
                       (Amendment No. 13)*

      Allergan Ligand Retinoid Therapeutics, Inc. (ALRI)
                       
                        (Name of Issuer)      

                    Callable Common Stock, par value $.001
                              
                (Title of Class of Securities)    

                      CUSIP No. 01849P107
                        (CUSIP Number)

                       Thomas F. Steyer
               Farallon Capital Management, L.L.C.
                 One Maritime Plaza, Suite 1325
                San Francisco, California  94111        
                         (415) 421-2132                 
                      
(Name, Address and Telephone Number of Person Authorized
to Receive Notices and Communications)

                          November 24, 1997                 

   
(Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on
Schedule 13G to report the acquisition which is the
subject of this Schedule 13D, and is filing this schedule
because of Rule 13d-1(b)(3) or (4), check the following
box  .

Note:  Six copies of this statement, including all
exhibits, should be filed with the Commission.  See Rule
13d-1(a) for other parties to whom copies are to be
sent.

* The remainder of this cover page shall be filled out
for a reporting person's initial filing on this form with
respect to the subject class of securities, and for any
subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

The information required on the remainder of this cover
page shall not be deemed to be "filed" for the purpose of
Section 18 of the Securities Exchange Act of 1934 ("Act")
or otherwise subject to the liabilities of that section
of that Act but shall be subject to all other provisions
of the Act (however, see the Notes).

PAGE
<PAGE>
                       SCHEDULE 13D

CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Farallon Capital Partners, L.P.

2    Check the Appropriate Box if a Member of a Group*  
    
     (a) 
                                                        
     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     California

     Number of Shares Beneficially Owned By Each
     Reporting Person With

7    Sole Voting Power

     -0-

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-

11   Aggregate Amount Beneficially Owned By Each Report-
     ing Person

     -0-

12   Check Box if the Aggregate Amount in Row (11)
     Excludes Certain Shares*                           
   
13   Percent of Class Represented by Amount in Row (11)

     0.0%

14   Type of Reporting Person*

     PN

     *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>
<PAGE>

                       SCHEDULE 13D

CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Farallon Capital Institutional Partners, L.P.

2    Check the Appropriate Box if a Member of a Group*  
    
     (a) 
                                                        
     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     California

     Number of Shares Beneficially Owned By Each
     Reporting Person With

7    Sole Voting Power

     -0-

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-  

10   Shared Dispositive Power

     -0-

11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-

12   Check Box if the Aggregate Amount in Row (11)
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%

14   Type of Reporting Person*

     PN

        *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>
<PAGE>
                       SCHEDULE 13D


CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Farallon Capital Institutional Partners II, L.P.

2    Check the Appropriate Box if a Member of a Group*  
    
     (a) 
                                                        
     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     California

     Number of Shares Beneficially Owned By Each
     Reporting Person With

7    Sole Voting Power

     -0-

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-

11   Aggregate Amount Beneficially Owned By Each Report-
     ing Person

     -0-

12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%

14   Type of Reporting Person*

     PN

              *SEE INSTRUCTIONS BEFORE FILLING OUT!
   
<PAGE>

<PAGE>
                       SCHEDULE 13D


CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Farallon Capital Institutional Partners III, L.P.

2    Check the Appropriate Box if a Member of a Group*  
    
     (a) 
                                                        
     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     Delaware

     Number of Shares Beneficially Owned By Each
     Reporting Person With

7    Sole Voting Power

     -0-

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-

11   Aggregate Amount Beneficially Owned By Each Report-
     ing Person

     -0-

12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%

14   Type of Reporting Person*

     PN

              *SEE INSTRUCTIONS BEFORE FILLING OUT!
   
<PAGE>


<PAGE>
                       SCHEDULE 13D


CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Tinicum Partners, L.P.

2    Check the Appropriate Box if a Member of a Group*  
    
     (a) 
                                                        
     (b) /x/  
                
3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     New York

     Number of Shares Beneficially Owned By Each
     Reporting Person With

7    Sole Voting Power

     -0-

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-

11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-

12   Check Box if the Aggregate Amount in Row (11)
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%

14   Type of Reporting Person*

     PN

       *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>    
<PAGE>
                       SCHEDULE 13D

CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Farallon Capital Management, L.L.C.

2    Check the Appropriate Box if a Member of a Group*  
    
     (a) 
                                                        
     (b) /x/                

3    SEC Use Only

4    Source of Funds*

     N/A   

5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     Delaware  

     Number of Shares Beneficially Owned By Each
     Reporting Person With 

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11)
     Excludes Certain Shares*                           
    
 
13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     IA, 00

      *SEE INSTRUCTIONS BEFORE FILLING OUT!             

<PAGE>
<PAGE>
                        SCHEDULE 13D

CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Farallon Partners, L.L.C.
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a) 
                                                        
     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A   

5    Check Box if Disclosure of Legal Proceedings is
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     Delaware  

     Number of Shares Beneficially Owned By Each    
     Reporting Person With 

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11)
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     00

           *SEE INSTRUCTIONS BEFORE FILLING OUT!        

PAGE
<PAGE>
                       SCHEDULE 13D


CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Enrique H. Boilini
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a)

     (b) /x/                                            
     
3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     Argentina

     Number of Shares Beneficially Owned By Each
     Reporting Person With

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     IN

           *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>
<PAGE>
                       SCHEDULE 13D


CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     David I. Cohen
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a)

     (b) /x/                                            
     
3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     South Africa   

     Number of Shares Beneficially Owned By Each
     Reporting Person With

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     IN

           *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>
<PAGE>
                       SCHEDULE 13D

CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Joseph F. Downes
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a)

     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A   

5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     United States  

     Number of Shares Beneficially Owned By Each
     Reporting Person With 

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     IN

           *SEE INSTRUCTIONS BEFORE FILLING OUT!

PAGE
<PAGE>
                       SCHEDULE 13D

CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Fleur E. Fairman
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a)

     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     United States  

     Number of Shares Beneficially Owned By Each
     Reporting Person With 

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           

13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     IN

            *SEE INSTRUCTIONS BEFORE FILLING OUT!       


<PAGE>
<PAGE>
                       SCHEDULE 13D



CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Jason M. Fish
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a)

     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     United States  

     Number of Shares Beneficially Owned By Each
     Reporting Person With 

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     IN

           *SEE INSTRUCTIONS BEFORE FILLING OUT!        

PAGE
<PAGE>
                             SCHEDULE 13D


CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Andrew B. Fremder
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a)

     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     United States  

     Number of Shares Beneficially Owned By Each
     Reporting Person With 

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     IN

           *SEE INSTRUCTIONS BEFORE FILLING OUT!        

PAGE
<PAGE>
                             SCHEDULE 13D

CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     William F. Mellin
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a)

     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     United States  

     Number of Shares Beneficially Owned By Each
     Reporting Person With 

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     IN

            *SEE INSTRUCTIONS BEFORE FILLING OUT!      

<PAGE>
<PAGE>
                       SCHEDULE 13D


CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Stephen L. Millham
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a)

     (b) /x/

3    SEC Use Only

4    Source of Funds*

     N/A

5    Check Box if Disclosure of Legal Proceedings is
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     United States  

     Number of Shares Beneficially Owned By Each
     Reporting Person With 

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     IN

            *SEE INSTRUCTIONS BEFORE FILLING OUT!       

<PAGE>
<PAGE>
                             SCHEDULE 13D

CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Meridee A. Moore
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a)

     (b) /x/
     
3    SEC Use Only

4    Source of Funds*

     N/A


5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     United States  

     Number of Shares Beneficially Owned By Each
     Reporting Person With 

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each 
     Reporting Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%

14   Type of Reporting Person*

     IN

                 *SEE INSTRUCTIONS BEFORE FILLING OUT!  


PAGE
<PAGE>
                       SCHEDULE 13D

CUSIP NO. 01849P107

1    Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     Thomas F. Steyer
     
2    Check the Appropriate Box if a Member of a Group*  
    
     (a)

     (b) /x/
     
3    SEC Use Only

4    Source of Funds*

     N/A    

5    Check Box if Disclosure of Legal Proceedings is 
     Required Pursuant to Items 2(d) or 2(e)

6    Citizenship or Place of Organization

     United States  

     Number of Shares Beneficially Owned By Each
     Reporting Person With 

7    Sole Voting Power

     -0-       

8    Shared Voting Power

     -0-

9    Sole Dispositive Power

     -0-

10   Shared Dispositive Power

     -0-
     
11   Aggregate Amount Beneficially Owned By Each Report-
     ing Person

     -0-
     
12   Check Box if the Aggregate Amount in Row (11) 
     Excludes Certain Shares*                           
    
13   Percent of Class Represented by Amount in Row (11)

     0.0%
     
14   Type of Reporting Person*

     IN

              *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>
<PAGE>
      This Amendment No. 13 to Schedule 13D amends the
Schedule 13D initially filed on July 20, 1995
(collectively, with all amendments thereto, the
"Schedule 13D").

Item 2.  Identity and Background.

     Paragraph (b) of Item 2 of the Schedule 13D is amended 
and restated in its entirety as follows:  

     (b)  The address of  the principal business and principal 
office of (i) the Partnerships, FCMLLC and FPLLC is One 
Maritime Plaza, Suite 1325, San Francisco, California  94111, 
and (ii) Offshore is Craigmuir Chambers, P.O. Box 71, Road 
Town, Tortola, British Virgin Islands.


     Item 5.  Interest in Securities of the Issuer.

     Item 5 is hereby amended and restated in its 
entirety as follows:

     A.     Farallon Capital Partners, L.P.

            (a), (b)     The information set forth in 
Rows 7, 8, 9, 10, 11 and 13 of the cover page hereto for 
FCP is incorporated herein by reference.   The percentage
amount set forth in Row 13 of such cover page and of each
other cover page filed herewith is calculated based upon
the 3,250,000 Shares outstanding as of November 14, 1997 as
reported by the Company in its Form 10Q for the
period ended September 30, 1997.<1>

            (c)   The trading dates, number of Shares transferred
and the price per Share for all transactions in the
Shares in the past 60 days are set forth on Schedule 
A hereto and are incorporated herein by reference.  
On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated).
All of the transfers of the Shares listed on the attached 
Schedule were part of such transaction.



<1>The Company filed a form 15-12G on November
 21, 1997 to terminate the registration of the Shares,
as a class, under Section 12 of the Securities Exchange
 Act of 1934, as amended.

PAGE
<PAGE>
            (d)     FPLLC as General Partner has the
power to direct the affairs of FCP, including the
disposition of the proceeds of the sale of the
Shares.  Steyer is the senior managing
member of FPLLC and Boilini, Cohen, Downes,
Fairman, Fish, Fremder, Mellin, Millham and
Moore are managing members of FPLLC. 

            (e)     As of November 24, 1997, the Reporting Person 
may no longer be deemed to be the beneficial owner of 5% 
or more of the total number of Shares.

      B.    Farallon Capital Institutional Partners, L.P.

            (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for FCIP
is incorporated herein by reference. 

            (c)    The trading dates, number of Shares transferred 
and the price per Share for all transactions in
the Shares in the past 60 days are set forth on Schedule B
hereto and are incorporated herein by reference.  
On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated).
All of the transfers of the Shares listed on the attached 
Schedule were part of such transaction.

            (d)     FPLLC as General Partner has the
power to direct the affairs of FCIP, including the
disposition of the proceeds of the sale of the
Shares.  Steyer is the senior managing
member of FPLLC and Boilini, Cohen, Downes,
Fairman, Fish, Fremder, Mellin, Millham and
Moore are managing members of FPLLC. 

            (e)     As of November 24, 1997, the Reporting 
Person may no longer be deemed to be the beneficial 
owner of 5% or more of the total number of Shares.

      C.   Farallon Capital Institutional Partners II,
L.P.
            (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for FCIP
II is incorporated herein by reference.

            (c)    The trading dates, number of Shares transferred
and the price per Share for all transactions in
the Shares in the past 60 days are set
PAGE
<PAGE>
forth on Schedule C
hereto and are incorporated herein by reference.  
On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash 
and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated).  
All of the transfers of 
the Shares listed on the attached Schedule were part of such 
transaction.

            (d)     FPLLC as General Partner has the
power to direct the affairs of FCIP II, including
the disposition of the proceeds of the sale of the
Shares.  Steyer is the senior managing
member of FPLLC and Boilini, Cohen, Downes,
Fairman, Fish, Fremder, Mellin, Millham and
Moore are managing members of FPLLC. 

            (e)        As of November 24, 1997, the Reporting 
Person may no longer be deemed to be the beneficial 
owner of 5% or more of the total number of Shares.

      D.   Farallon Capital Institutional Partners III,
L.P.

            (a), (b)  The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for FCIP
III is incorporated herein by reference. 

            (c)    The trading dates, number of Shares transferred
and the price per Share for all transactions in 
the Shares in the past 60 days are set forth on Schedule D
hereto and are incorporated herein by reference.  
On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated).
All of the transfers of  the Shares listed on the attached
Schedule were part of such transaction.

            (d)     FPLLC as General Partner has the
power to direct the affairs of FCIP III, including the
disposition of the proceeds of the sale of the 
Shares.  Steyer is the senior managing member of
FPLLC and Boilini, Cohen, Downes, Fairman,
Fish, Fremder, Mellin, Millham and Moore are
managing members of FPLLC.

            (e)     As of November 24, 1997, the Reporting 
Person may no longer be deemed to be the beneficial 
owner of 5% or more of the total number of Shares.
PAGE
<PAGE>
      E.    Tinicum Partners, L.P.

            (a), (b) The information set forth in Rows 7,
8, 9, 10, 11 and 13 of the cover page hereto for Tinicum 
is incorporated herein by reference. 

            (c)    The trading dates, number of Shares transferred
and the price per Share for all transactions in 
the Shares in the past 60 days are set 
forth on Schedule E
hereto and are incorporated herein by reference.  
On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated).  
All of the transfers of the Shares listed on the
attached Schedule were part of such transaction.

            (d)   FPLLC as General Partner has the
power to direct the affairs of Tinicum, including
the disposition of the proceeds of the sale of the
Shares.  Steyer is the senior managing
member of FPLLC and Boilini, Cohen, Downes,
Fairman, Fish, Fremder, Mellin, Millham and Moore
are managing members of FPLLC. 
 
            (e)     As of November 24, 1997, the Reporting
Person may no longer be deemed to be the beneficial
owner of 5% or more of the total number of Shares.

      F.    Farallon Capital Management, L.L.C.

            (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for 
FCMLLC is incorporated herein by reference. 

            (c)    The trading dates, number of Shares transferred
and the price per Share for all transactions in 
the Shares in the past 60 days are set forth on Schedule F
hereto and are incorporated herein by reference.
On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated). 
All of the transfers of the Shares listed on the attached
Schedule were part of such 
transaction.

            (d)     FCMLLC, as an investment adviser, has
the power to direct the disposition of the proceeds
of the sale of the Shares held by the Managed Accounts. 
Steyer is the senior managing member of 
PAGE
<PAGE>
FCMLLC, and 
Boilini, Cohen, Downes, Fish, Fremder, Millham, Mellin, 
and Moore are managing members of FCMLLC. 

             (e)     As of November 24, 1997, the Reporting 
Person may no longer be deemed to be the beneficial 
owner of 5% or more of the total number of Shares.

      G.    Farallon Partners, L.L.C.

            (a), (b)     The information set forth in rows
7, 8, 9, 10, 11, and 13 of the cover page hereto for 
FPLLC is incorporated herein by reference.

            (c)     None.

            (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of the sale of
the Shares.  Steyer is the senior managing
member of FPLLC, and Boilini, Cohen, Downes,
Fairman, Fish, Fremder, Mellin, Millham and Moore are
managing members of FPLLC.

            (e)     As of November 24, 1997, the Reporting 
Person may no longer be deemed to be the beneficial 
owner of 5% or more of the total number of Shares.

     H.     Enrique H. Boilini

            (a),(b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for 
Boilini is incorporated herein by reference. 

            (c)     None.

            (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of the sale
of the Shares.  FCMLLC, as an investment
adviser, has the power to direct the disposition of the
proceeds of the sale of the Shares held by the
Managed Accounts.  Boilini is a managing member
of FCMLLC and FPLLC.


            (e)     As of November 24, 1997, the Reporting
Person may no longer be deemed to be the beneficial
owner of 5% or more of the total number of Shares.

     I.     David I. Cohen
PAGE
<PAGE>
           (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for Cohen
is incorporated herein by reference. 

            (c)     None.

            (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of the
sale of  the Shares.  FCMLLC, as an
investment adviser, has the power to direct the
disposition of the proceeds of the sale of the
Shares held by the Managed Accounts.  Cohen is a 
managing member of FCMLLC and FPLLC.

            (e)     As of November 24, 1997, the Reporting 
Person may no longer be deemed to be the beneficial 
owner of 5% or more of the total number of Shares.

     J.     Joseph F. Downes

            (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for 
Downes is incorporated herein by reference. 

            (c)     None.

            (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of the
sale of the Shares.  FCMLLC, as an
investment adviser, has the power to direct the
disposition of the proceeds of the sale of the
Shares held by the Managed Accounts.  Downes
is a managing member of FCMLLC and FPLLC.

            (e)     As of November 24, 1997, the Reporting 
Person may no longer be deemed to be the beneficial 
owner of 5% or more of the total number of Shares.

      K.     Fleur E. Fairman

            (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for
Fairman is incorporated herein by reference. 

            (c)     None.
PAGE
<PAGE>
            (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of the
sale of the Shares.  Fairman is a managing member 
of FPLLC.

            (e)     As of November 24, 1997, the Reporting 
Person may no longer be deemed to be the beneficial 
owner of 5% or more of the total number of Shares.

     L.     Jason M. Fish

            (a),(b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for Fish 
is incorporated herein by reference. 

             (c)     None.

            (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of the
sale of the Shares.  FCMLLC, as an
investment adviser, has the power to direct the
disposition of the proceeds of the sale of the
Shares held by the Managed Accounts. 
Fish is a managing member of FCMLLC and FPLLC.

            (e)     As of November 24, 1997, the 
Reporting Person may no longer be deemed to
be the beneficial owner of 5% or more of the 
total number of Shares.

     M.     Andrew B. Fremder

            (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for 
Fremder is incorporated herein by reference. 

            (c)     None.

            (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of
the sale of the Shares.  FCMLLC, as an
investment adviser, has the power to
direct the disposition of the proceeds of the
sale of the Shares held by the Managed 
Accounts.  Fremder is a managing
member of FCMLLC and FPLLC.

            (e)     As of November 24, 1997, the
Reporting Person may no longer be deemed to
be the beneficial owner of 5% or more of the 
total number of Shares.
PAGE
<PAGE>
      N.    William F. Mellin

            (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for 
Mellin is incorporated herein by reference. 

            (c)     None.

            (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of the
sale of the Shares.  FCMLLC, as an investment 
adviser, has the power to
direct the disposition of the proceeds of the sale 
of the Shares held by the Managed Accounts. 
Mellin is a managing member of FCMLLC and FPLLC.

            (e)     As of November 24, 1997, the 
Reporting Person may no longer be deemed to be
the beneficial owner of 5% or more of the total
number of Shares.

      O.     Stephen L. Millham

            (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for 
Millham is incorporated herein by reference. 

            (c)     None.

            (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of the
sale of the Shares.  FCMLLC, as an
investment adviser, has the power to
direct the disposition of the proceeds of the sale of the
Shares held by the Managed Accounts.
Millham is a managing member of FCMLLC
and FPLLC.

            (e)     As of November 24, 1997, the
Reporting Person may no longer be deemed 
to be the beneficial owner of 5% or more of
the total number of Shares.

     P.     Meridee A. Moore

            (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for Moore
is incorporated herein by reference. 

          (c)     None.
PAGE
<PAGE>
          (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of the
sale of the Shares.  FCMLLC, as an
investment adviser, has the power to direct the
disposition of the proceeds of the sale of the
Shares held by the Managed Accounts.  
Moore is a managing member of FCMLLC
and FPLLC.

            (e)     As of November 24, 1997, the 
Reporting Person may no longer be deemed to 
be the beneficial owner of 5% or more of the
 total number of Shares.

     Q.     Thomas F. Steyer

            (a), (b)     The information set forth in Rows
7, 8, 9, 10, 11 and 13 of the cover page hereto for 
Steyer is incorporated herein by reference. 

            (c)     None. 

            (d)     FPLLC as General Partner has the
power to direct the affairs of the Partnerships,
including the disposition of the proceeds of the
sale of the Shares.   FCMLLC, as an investment 
adviser, has the power to direct the disposition 
of the proceeds of the sale of the Shares held
by the Managed Accounts.  Steyer is the senior
managing member of FCMLLC and FPLLC.

            (e)     As of November 24, 1997, the Reporting
Person may no longer be deemed to be the beneficial 
owner of 5% or more of the total number of Shares.

     The Shares reported hereby for the Partnerships and
FCMLLC on behalf of the Managed Accounts are 
owned directly by such entities.  Each of Boilini, Cohen, 
Downes, Fish, Fremder, Mellin, Millham, Moore and
Steyer may be deemed, as managing members of FPLLC
and FCMLLC, to be the beneficial owner of all such
Shares.  Each of FPLLC and Fairman, as a managing 
member of FPLLC, may be deemed to be the 
beneficial owner of all Shares
owned by the Partnerships.  FCMLLC may 
be deemed to be the beneficial owner of all such Shares 
owned by the Managed Accounts.  Each of FCMLLC, 
FPLLC, Boilini, Cohen, Downes, Fairman, Fish, Fremder, 
Mellin, Millham, Moore and Steyer hereby disclaim any
beneficial ownership of any such Shares.

<PAGE>
<PAGE>
                         SIGNATURES


      After reasonable inquiry and to the best of our
knowledge and belief, the undersigned certify that the
information set forth in this statement is true, complete
and correct.  

Dated: December 4, 1997


                    /s/ Thomas F. Steyer          
                    FARALLON PARTNERS, L.L.C., 
                    on its own behalf and as
                    General Partner of 
                    FARALLON CAPITAL PARTNERS, L.P.,    
                    FARALLON CAPITAL INSTITUTIONAL
                    PARTNERS, L.P., FARALLON
                    CAPITAL INSTITUTIONAL PARTNERS
                    II, L.P., FARALLON CAPITAL
                    INSTITUTIONAL PARTNERS III, 
                    L.P., and TINICUM PARTNERS, L.P. 
                    By Thomas F. Steyer, 
                    Senior Managing Member



                    /s/ Thomas F. Steyer             
                    FARALLON CAPITAL MANAGEMENT, L.L.C.
                    By Thomas F. Steyer,
                    Senior Managing Member


                    /s/ Thomas F. Steyer                
                    Thomas F. Steyer,
                    individually and as 
                    attorney-in-fact for each
                    of Enrique H. Boilini, David I.
                    Cohen, Joseph F. Downes,
                    Fleur E. Fairman, Jason M. Fish,
                    Andrew B. Fremder, William 
                    F. Mellin, Stephen L.
                    Millham, and Meridee A. Moore. 

     The Powers of Attorney each executed by Boilini, 
Cohen, Downed, Fairman, Fish, Fremder, Mellin and Moore 
authorizing Steyer to sign and file this Schedule 13D on
each person's behalf was filed with Amendment No. 1
to the Schedule 13D filed with the SEC on September
26, 1997 by such Reporting Persons with Respect to 
the Common Stock of Sphere Drake Holdings 
Limited are hereby incorporated by reference.

PAGE
<PAGE>

     SCHEDULE A

FARALLON CAPITAL PARTNERS, L.P. 

TRANSACTION               NO. OF SHARES     PRICE
DATE   TRANSFERRED   PER SHARE
                                              (including commission)


11/24/97                 306,011                   $21.97<2>




<2> On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated). 
<PAGE>
     SCHEDULE B
FARALLON CAPITAL INSTITUTIONAL 

PARTNERS, L.P. 

TRANSACTION          NO. OF SHARES     PRICE
DATE   TRANSFERRED   PER SHARE
                                    (including commission)

11/24/97               355,691                   $21.97<2>







<2> On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated). <PAGE>
     SCHEDULE C
FARALLON CAPITAL INSTITUTIONAL 
PARTNERS II, L.P. 
 TRANSACTION     NO. OF SHARES     PRICE
DATE   TRANSFERRED   PER SHARE
                              (including commission)


11/24/97        96,667                   $21.97<2>





<2> On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated). 

<PAGE>
                                         SCHEDULE D

FARALLON CAPITAL INSTITUTIONAL 

PARTNERS III, L.P.


 TRANSACTION  NO. OF SHARES     PRICE
DATE   TRANSFERRED   PER SHARE
                                      (including commission)

11/24/97            22,100                   $21.97<2>





<2> On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share
 (to be paid,
per Share, as $7.69 in cash and approximately
 0.97 shares of 
common stock of Ligand Pharmaceuticals
, Incorporated). 
<PAGE>
     SCHEDULE E
TINICUM PARTNERS, L.P.

 TRANSACTION    NO. OF SHARES     PRICE
DATE   TRANSFERRED   PER SHARE
                                      (including commission)


11/24/97            51,990                   $21.97<2>





<2> On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated). <PAGE>
     SCHEDULE F
FARALLON CAPITAL MANAGEMENT, L.L.C.

 TRANSACTION     NO. OF SHARES     PRICE
DATE   TRANSFERRED   PER SHARE
                                    (including commission)


11/24/97                82,467                   $21.97<2>

11/24/97                30,290                   $21.97<2>

11/24/97                60,398                   $21.97<2>



<2> On November 24, 1997, Ligand Pharmaceuticals, 
Incorporated exercised its option to acquire
all of the outstanding Shares at $21.97 per Share (to be paid,
per Share, as $7.69 in cash and approximately 0.97 shares of 
common stock of Ligand Pharmaceuticals, Incorporated). 


</PAGE>   


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