INTERCARDIA INC
10-Q, 1996-08-13
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 10-Q


  X    Quarterly  report  pursuant to Section 13 or 15(d) of the Securities
- -----  Exchange Act of 1934. For the quarterly period ended June 30, 1996.

       Transition report pursuant to Section 13 or 15(d) of the Securities 
- -----  Exchange Act of 1934. For the transition period from _____ to _____.

                             Commission File Number
                                     0-27410


                                INTERCARDIA, INC.
             (Exact Name of Registrant as Specified in its Charter)


         Delaware                                        56-1924222
(State or other jurisdiction of                      (I.R.S. Employer 
 incorporation or organization)                    Identification Number)

P.O. Box 14287
3200 East Highway 54
Cape Fear Bldg., Suite 300
Research Triangle Park, NC                                          27709
(Address of Principal Executive Office)                           (Zip Code)

Registrant's Telephone Number, Including Area Code               919-558-8688



Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or such shorter period that the registrant was required
to file such reports),  and (2) has been subject to such filing requirements for
the past 90 days.    YES [X]   NO [ ]

Indicate the number of shares  outstanding  of each of the  issuer's  classes of
common stock, as of the latest practicable date.


               Class                          Outstanding as of August 6, 1996
         ------------------                   --------------------------------
Common Stock, par value $.001                             6,726,621 Shares


<PAGE>


                                INTERCARDIA, INC.

                               INDEX TO FORM 10-Q


<TABLE>
<CAPTION>
                                                                                                        PAGE
PART I.  FINANCIAL INFORMATION

<S>                                                                                                <C>
                  Item 1.           Financial Statements

                  Consolidated Balance Sheets as of June 30, 1996 (unaudited)
                  and September 30, 1995 . . . . . . . . . . . . . . . . . . . . . . . . . . . .   3

                  Consolidated Statements of Operations for the Three Months and
                  Nine Months ended June 30, 1996 and 1995 (unaudited)  . . . . . . . . . . . . .  4

                  Consolidated Statements of Cash Flows for the Nine Months ended
                  June 30, 1996 and 1995 (unaudited)   . . . . . . . . . . . . . . . . . . . . .   5

                  Notes to Unaudited Consolidated Financial Statements . . . . . . . . . . . . .   6


                  Item 2.           Management's Discussion and Analysis of Financial
                                    Condition and Results of Operations  . . . . . . . . . . . .  10


PART II. OTHER INFORMATION

                  Item 6.           Exhibits and Reports on Form 8-K . . . . . . . . . . . .  . . 14

                  SIGNATURE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  . .. . 15

</TABLE>


                                       2

<PAGE>


                                INTERCARDIA, INC.

                           CONSOLIDATED BALANCE SHEETS
                  (Dollars in thousands, except per share data)

<TABLE>
<CAPTION>
                                                                                    June 30,            September 30,
                                                                                      1996                   1995
                                                                                ------------------     -----------------
                                                                                   (Unaudited)
                                               ASSETS
<S>                                                                              <C>                   <C>             
Current assets:
      Cash and cash equivalents                                                  $         20,102      $          1,122
      Marketable securities                                                                16,895                     -
      Accounts receivable                                                                   1,621                     -
      Other current assets                                                                    128                     8
                                                                                ------------------     -----------------
               Total current assets                                                        38,746                 1,130

Marketable securities                                                                       1,019                     -
Property and equipment, net                                                                   285                   150
Other assets                                                                                    8                    10
                                                                                ------------------     -----------------
                                                                                 $         40,058      $          1,290
                                                                                ==================     =================


                                   LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)
Current liabilities:
      Accounts payable                                                           $            170      $            276
      Accrued expenses                                                                      2,162                   835
      Current portion of capital lease obligations                                             35                    24
      Advances from Interneuron                                                                13                   172
                                                                                ------------------     -----------------
               Total current liabilities                                                    2,380                 1,307

Long-term portion of capital lease obligations                                                118                   115

Minority interest                                                                             632                     -

Stockholders' equity (deficit):
      Preferred stock, $.01 par value,  authorized  3,000,000  shares:  Series A
           Preferred Stock,  1,500,000 designated,  no shares and 692,621 shares
           issued and outstanding at June 30, 1996 and
           September 30, 1995, respectively                                                     -                     7
      Common stock, $.001 par value, 40,000,000 shares authorized,
           6,726,621 and 3,500,000 shares issued and outstanding at
           June 30, 1996 and September 30, 1995, respectively                                   7                     3
      Additional paid-in capital                                                           39,556                 4,345
      Deferred compensation                                                                 (216)                     -
      Accumulated deficit                                                                 (2,419)               (4,487)
                                                                                ------------------     -----------------
               Total stockholders' equity (deficit)                                        36,928                 (132)
                                                                                ------------------     -----------------
                                                                                 $         40,058      $          1,290
                                                                                ==================     =================
</TABLE>

         The accompanying notes are an integral part of these unaudited
                       consolidated financial statements.

                                       3

<PAGE>


                                INTERCARDIA, INC.

                      CONSOLIDATED STATEMENTS OF OPERATIONS
                                   (Unaudited)
                      (In thousands, except per share data)


<TABLE>
<CAPTION>
                                                  Three Months Ended                   Nine Months Ended
                                                       June 30,                             June 30,
                                            --------------------------------     -------------------------------
                                                1996              1995               1996             1995
                                            -------------     -------------      -------------    --------------
<S>                                         <C>                                  <C>         
Revenue:
      Contract revenue                      $           5                        $      5,009
      Investment income                               503     $          23               826      $         32
                                            -- -----------    -- -----------     -- ----------     -- ----------
               Total revenue                          508                23              5,835               32
                                            --- ----------    -- -----------     -- -----------    -- ----------

Costs and expenses:
      Research and development                        865               510             1,770               983
      General and administrative                      494               218             1,365               337
                                            -- -----------    -- -----------     -- ----------     -- ----------
               Total costs and expenses             1,359               728             3,135             1,320
                                            -- -----------    -- -----------     -- ----------     -- ----------

Income (loss) from operations                       (851)             (705)             2,700           (1,288)
Minority interest                                      74                 -             (632)                 -
                                            -- -----------    -- -----------     -- ----------     -- ----------

Net income (loss)                           $       (777)     $       (705)      $       2,068     $    (1,288)
                                            == ===========    == ===========     == ===========    == ==========

Net income (loss) per common share           $     (0.12)     $      (0.14)      $        0.36     $     (0.26)
                                            === ==========    == ===========     == ===========    == ==========

Weighted average common shares
  outstanding                                       6,727             4,874             5,812             4,874
                                            == ===========    == ===========     == ==========    == ===========
</TABLE>

         The accompanying notes are an integral part of these unaudited
                       consolidated financial statements.

                                       4

<PAGE>


                                INTERCARDIA, INC.

                      CONSOLIDATED STATEMENTS OF CASH FLOWS
                                   (Unaudited)
                                 (In thousands)


<TABLE>
<CAPTION>
                                                                                            Nine Months Ended
                                                                                                 June 30,
                                                                                   -------------------------------------
                                                                                        1996                  1995
                                                                                   ---------------       ---------------
<S>                                                                                <C>                   <C>           
Cash flows from operating activities:
      Net income (loss)                                                            $        2,068        $      (1,288)
      Adjustments to reconcile net income (loss) to net cash from
          operating activities:
               Depreciation and amortization                                                   49                     2
               Minority interest in net income of consolidated
                    subsidiary                                                                632                     -
               Change in assets and liabilities:
                    Accounts receivable                                                   (1,621)                     -
                    Other assets                                                            (120)                   (9)
                    Accounts payable                                                        (106)                    11
                    Accrued expenses                                                        1,327                   191
                                                                                   -- ------------       -- ------------
Net cash provided by (used in) operating activities                                         2,229               (1,093)
                                                                                   -- ------------       -- ------------

Cash flows from investing activities:
      Purchase of marketable securities                                                  (19,914)                     -
      Proceeds from maturities and sales of marketable securities                           2,000                     -
      Purchases of property and equipment                                                   (145)                  (40)
                                                                                   -- ------------       -- ------------
Net cash used in investing activities                                                    (18,059)                  (40)
                                                                                   -- ------------       -- ------------

Cash flows from financing activities:
      Net proceeds from issuance of stock                                                  34,992                 2,984
      Advances from (payments to) Interneuron, net                                          (159)                   384
      Principal payments on capital lease obligations                                        (23)                     -
                                                                                   -- ------------       -- ------------
Net cash provided by financing activities                                                  34,810                 3,368
                                                                                   -- ------------       -- ------------

Net increase in cash and cash equivalents                                                  18,980                 2,235
Cash and cash equivalents at beginning of period                                            1,122                     -
                                                                                   == ============       == ============
Cash and cash equivalents at end of period                                         $       20,102        $        2,235
                                                                                   == ============       == ============
</TABLE>

         The accompanying notes are an integral part of these unaudited
                       consolidated financial statements.


                                       5
<PAGE>




                                INTERCARDIA, INC.

              NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS



A.       Basis of Presentation

         Intercardia,  Inc. was  incorporated in Delaware on March 15, 1994, and
is  a   majority-owned   subsidiary   of   Interneuron   Pharmaceuticals,   Inc.
("Interneuron").  The "Company" refers to Intercardia,  Inc. ("Intercardia") and
its  majority-owned  subsidiaries,  Aeolus  Pharmaceuticals,  Inc.,  a  Delaware
corporation ("Aeolus"), and CPEC, Inc., a Nevada corporation ("CPEC"). Aeolus is
a 61.2% owned subsidiary of Intercardia and CPEC is an 80.0% owned subsidiary of
Intercardia. In January 1996, Interneuron acquired directly from the former CPEC
minority  stockholders  the remaining 20.0% of the outstanding  capital stock of
CPEC not owned by Intercardia.

The  Company  focuses  on  development  of  therapeutics  for the  treatment  of
cardiovascular and pulmonary  disease.  The Company has directed the majority of
its efforts toward the development and clinical trials of bucindolol, a compound
currently in Phase III clinical  trials for the  treatment of  congestive  heart
failure.  This  clinical  trial,  which  commenced in June 1995, is known as the
Beta-blocker Evaluation of Survival Trial (the "BEST Study") and is sponsored by
the National Institutes of Health and the Department of Veterans Affairs.

         The  consolidated   financial   statements   include  the  accounts  of
Intercardia and its subsidiaries,  CPEC and Aeolus. All significant intercompany
activity has been eliminated.  The consolidated  financial  statements  included
herein have been prepared by the Company  without  audit,  pursuant to the rules
and regulations of the Securities and Exchange  Commission.  Certain information
and footnote  disclosures  normally included in financial statements prepared in
accordance with generally accepted accounting  principles have been condensed or
omitted  pursuant to such rules and  regulations.  In the opinion of management,
the  accompanying   unaudited  consolidated  financial  statements  include  all
adjustments  (consisting  only of normal  recurring  adjustments)  necessary  to
present fairly the consolidated  financial  position,  results of operations and
cash flows of the Company. The consolidated financial statements included herein
should be read in conjunction with the audited consolidated financial statements
and the notes thereto included in the Company's  initial public offering ("IPO")
prospectus  dated  February  1, 1996.  Results  for the  interim  period are not
necessarily  indicative of the results for any other  interim  period or for the
full fiscal year.

B.       Cash equivalents and marketable securities:

         The Company  considers only those  investments which are highly liquid,
readily  convertible  to cash and which mature  within three months from date of
purchase as cash equivalents.

         The Company considers its investment  portfolio  available-for-sale  as
defined in Statement of Financial  Accounting  Standards ("SFAS") No. 115. There
were no material unrealized gains

                                       6

<PAGE>


or losses nor any material  differences  between the  estimated  fair values and
costs of securities in the investment portfolio at June 30, 1996.

C.       Income Taxes:

         No income tax  provision  or benefit has been  provided  for income tax
purposes,  as the Company utilized  projected  expenses for the remainder of the
fiscal  year and net  operating  loss  carryforwards  to offset  the net  income
realized during the nine months ended June 30, 1996.

D.       Stockholders' Equity:

         In February 1996,  Intercardia  completed an IPO of 2,530,000 shares of
Intercardia  Common  Stock at $15.00 per share,  resulting  in net  proceeds  to
Intercardia of approximately  $35,000,000.  Interneuron purchased 333,333 of the
IPO shares at the IPO price for a total of  $5,000,000.  As a result of the IPO,
Interneuron's  ownership  of  Intercardia  decreased  to  59.7%  from  87.8%  at
September  30, 1995.  All  outstanding  shares of Series A Preferred  Stock were
automatically converted into shares of Common Stock upon the closing of the IPO.

         The minority interest in the June 30, 1996  Consolidated  Balance Sheet
and the Consolidated  Statement of Operations for the nine months ended June 30,
1996 reflects the 20% minority  interest in net income earned by CPEC during the
nine  months  ended  June 30,  1996,  offset by 20% of the  previous  cumulative
deficit incurred by CPEC since its acquisition by Intercardia.

         In November  1995,  Intercardia  reduced the number of shares of Common
Stock authorized from 97,000,000 to 40,000,000 shares,  adopted the Intercardia,
Inc.  Employee  Stock  Purchase Plan under which 100,000  shares of Common Stock
were reserved for  issuance,  and increased the number of shares of Common Stock
reserved for  issuance  under the 1994 Stock  Option Plan  ("Option  Plan") from
750,000 to 1,000,000 shares.

         In June 1996,  Intercardia's Board of Directors amended the Option Plan
to, among other things,  increase the number of shares of Common Stock  reserved
for issuance under the Option Plan from 1,000,000 shares to 1,500,000 shares.

E.       Agreements:

         In December  1995,  the Company  executed a  Development  and Marketing
Collaboration and License Agreement (the "Astra Merck Collaboration") with Astra
Merck Inc. ("Astra Merck") to provide for the development, commercialization and
marketing in the United States of a twice-daily  formulation  of bucindolol  for
the  treatment  of  congestive  heart  failure.  Astra  Merck  made  an  initial
$5,000,000  payment  to the  Company  and  assumed  responsibility  for  certain
liabilities  owed by the  Company.  Astra Merck will fund  certain  expenses and
expenditures  incurred in connection with the development and  commercialization
of the twice-daily formulation of bucindolol in the United States, including any
payments  due under the BEST Study.  Astra Merck will also pay  royalties to the
Company on net sales of the twice-daily  formulation in the United States,  make
additional  payments to the Company if certain milestones are achieved,  and

                                       7

<PAGE>

pay the royalties due to Bristol-Myers  Squibb Company  ("Bristol-Myers")  under
its license of bucindolol  with the Company.  Under the terms of the Astra Merck
Collaboration, the Company has agreed to pay Astra Merck $10,000,000 in December
1997 and up to  $11,000,000  for  one-third  of product  launch  costs  incurred
beginning  when the  Company  files a New Drug  Application  (an  "NDA") for the
twice-daily formulation and continuing through the first 12 months subsequent to
the first  commercial sale of the  formulation.  In the event the Company elects
not to make these payments,  the royalties payable by Astra Merck to the Company
will be significantly reduced. The Astra Merck Collaboration continues in effect
until  December 31, 2010,  subject to Astra Merck's  option to extend it for two
additional five-year periods.  During the nine months ended June 30, 1996, Astra
Merck made payments or assumed  liabilities of  approximately  $2,647,000 on the
Company's behalf.  These amounts did not flow through the Company's Statement of
Operations,  as they were offset against related expenses.  Astra Merck had paid
approximately  $1,044,000 of this amount by June 30, 1996,  and  therefore,  the
remaining unpaid amount of  approximately  $1,537,000 was included as offsetting
accounts receivables and accrued expenses on the Company's Balance Sheet at June
30, 1996.

         In  December  1995,  the  Company and  Interneuron  entered  into a tax
allocation  agreement  to provide,  among other  things,  for the payment of tax
liabilities and entitlement to tax refunds and the allocation of  responsibility
and the providing of cooperation in the filing of tax returns.  Also in December
1995,   Intercardia  and  Interneuron  entered  into  an  intercompany  services
agreement which provides,  among other things,  for Intercardia to adopt certain
policies and  procedures  and for  Interneuron  to include  Intercardia  and its
employees in certain  programs  administered  by  Interneuron,  at cost, such as
insurance  and health  care  plans,  and to  provide  research  and  development
services  to the Company  upon  request,  on a cost plus basis.  Pursuant to the
intercompany services agreement, Intercardia has agreed to offer Interneuron the
right to purchase  shares of Common Stock at fair market value,  if necessary to
provide that  Interneuron's  equity ownership in Intercardia does not fall below
51.0%.

         In March 1996,  Intercardia  amended its  building  lease  agreement to
increase its leased space to approximately  6,200 square feet from approximately
2,500  square  feet and to extend the end of the lease term from May 31, 2000 to
April 30, 2001.  Total future minimum lease payments  increased to approximately
$580,000 at March 31, 1996 from approximately $212,000 at September 30, 1995.

         In April 1996, the Company  entered into an Agreement for a Feasibility
Study   ("Feasibility  Study  Agreement")  and  a  License  Agreement  ("License
Agreement")  with  Jago  Pharma  AG  and  its  affiliates  ("Jago").  The  study
contemplated  by the  Feasibility  Study  Agreement is designed to determine the
feasibility of developing a once-daily  formulation  of bucindolol.  The Company
made  an  initial  payment  of  $390,000  upon  signing  the  Feasibility  Study
Agreement.  The Feasibility Study Agreement expires 60 days after receipt by the
Company of the  Preliminary  Pharmacokinetic  Study from Jago,  or, if  earlier,
immediately  upon a  default  or breach of  confidentiality  provisions  or upon
another  breach or  default  not cured  within 30 days of notice  thereof,  upon
bankruptcy of a party or if the Company determines in its sole discretion not to
proceed with the next phase of the study. The License  Agreement has a perpetual
term, but contains similar breach and bankruptcy  termination  provisions as the
Feasibility Study Agreement.  The Company will make additional  payments to Jago
if certain milestones are achieved,  and will

                                       8

<PAGE>

pay royalties to Jago on net sales of the once-daily  formulation,  if developed
under  these  agreements,  until  the  expiration  of the  relevant  patent on a
country-by-country basis (or 15 years, if no patent is issued in that country).


                                       9

<PAGE>


Item 2.  Management's Discussion and Analysis of Financial Condition and Results
         of Operations.

Introduction

         Statements  in this Form 10-Q that are not  descriptions  of historical
facts  are   forward-looking   statements   that  are   subject   to  risks  and
uncertainties.  Actual  results  could differ  materially  from those  currently
anticipated  due to a  number  of  factors,  including  those  set  forth in the
Company's SEC filings under "Risk  Factors",  including,  in  particular,  risks
relating  to   uncertainties   relating  to  clinical   trials,   dependence  on
collaborative   partners,   the  early  stage  of  products  under  development,
dependence on one product, government regulations and competition.

         The  following  discussion  should  be read  in  conjunction  with  the
unaudited   Consolidated   Financial  Statements  and  Notes  thereto  appearing
elsewhere in this report. Unless the context indicates otherwise, all references
to the Company include  Intercardia,  Inc. and its subsidiaries,  CPEC, Inc. and
Aeolus Pharmaceuticals, Inc.

         Intercardia was  incorporated in March 1994 and had no operations until
September  1994,  when  Intercardia  acquired  80.0% of CPEC.  In  January  1996
Interneuron  acquired  directly from the former CPEC minority  stockholders  the
remaining  20.0%  of  the  outstanding  capital  stock  of  CPEC  not  owned  by
Intercardia. CPEC has a worldwide license for the development,  distribution and
sale of  bucindolol,  a product  currently in Phase III clinical  trials for the
treatment of congestive heart failure. In July 1995,  Intercardia acquired 61.2%
of Aeolus. Aeolus is conducting early stage development on catalytic antioxidant
small molecules as therapeutics for a variety of conditions,  including neonatal
respiratory distress syndrome and resulting broncho-pulmonary  dysplasia, stroke
and asthma.

         The Company will incur additional charges to operations relating to the
acquisition  of CPEC in the event that  certain  milestones  are achieved in the
development and commercialization of bucindolol. Achievement of these milestones
would require two  additional  payments,  each of 75,000  shares of  Interneuron
common stock,  subject to adjustment  based on the price of  Interneuron  common
stock at the time of  issuance.  In  exchange  for  Interneuron  providing  such
shares,  the Company will pay  Interneuron  the value of such shares,  in either
cash or Intercardia  Common Stock,  at  Intercardia's  option.  Each  additional
payment  would have a minimum and maximum  charge to the Company of $750,000 and
$1,875,000, respectively.

Results of Operations

         For the three months and nine months ended June 30, 1996, revenues were
$508,000 and $5,835,000, respectively, versus $23,000 and $32,000 of revenue for
the three months and nine months ended June 30, 1995, respectively. The majority
of the revenue  recognized  during the three months ended June 30, 1996 resulted
from investment  income earned on the IPO proceeds received in February 1996. In
addition,  the  revenue  for the nine  months  ended June 30,  1996  includes an
initial  payment of  $5,000,000  received in December 1995 under the Astra Merck
Collaboration.

                                       10

<PAGE>


         Research and development  ("R&D") expenses  increased $355,000 (70%) to
$865,000 for the three  months  ended June 30, 1996 from  $510,000 for the three
months ended June 30, 1995. R&D expenses  increased $787,000 (80%) to $1,770,000
for the nine months ended June 30, 1996 from  $983,000 for the nine months ended
June 30, 1995. These increases are primarily the result of $355,000 and $878,000
of new R&D expenses  related to Aeolus incurred during the three months and nine
months ended June 30,1996,  respectively.  Aeolus was acquired by Intercardia in
July 1995.

         Bucindolol  development activities and related costs were significantly
higher during fiscal 1996 than fiscal 1995.  However,  as the terms of the Astra
Merck  Collaboration  require Astra Merck to pay for certain expenses related to
bucindolol  development,  the net cost to Intercardia for bucindolol development
was  approximately  the same during  fiscal 1996 as for fiscal 1995.  During the
nine  months  ended  June  30,  1996,  Astra  Merck  made  payments  or  assumed
liabilities of approximately  $2,647,000 on the Company's behalf.  These amounts
did not flow through the Company's Statement of Operations,  as they were offset
against related expenses.  Astra Merck had paid approximately $1,044,000 of this
amount  by June  30,  1996,  and  therefore,  the  remaining  unpaid  amount  of
approximately  $1,537,000 was included as offsetting  accounts  receivables  and
accrued expenses on the Company's Balance Sheet at June 30, 1996.

         General and  administrative  ("G&A") expenses increased to $494,000 and
$1,365,000   for  the  three  months  and  nine  months  ended  June  30,  1996,
respectively,  from  $218,000  and $337,000 for the three months and nine months
ended  June  30,  1995,   respectively.   These  increases   resulted  from  the
installation  during  fiscal 1995 of a  management  team to oversee  operations.
Payroll  costs of $265,000 and $792,000  represent  the majority of G&A expenses
for the three months and nine months ended June 30, 1996, respectively.

         The minority interest in the June 30, 1996  Consolidated  Balance Sheet
and the Consolidated  Statement of Operations for the nine months ended June 30,
1996 reflects the 20% minority  interest in net income earned by CPEC during the
nine  months  ended  June 30,  1996,  offset by 20% of the  previous  cumulative
deficit incurred by CPEC since its acquisition by Intercardia.

Liquidity and Capital Resources

         In February 1996,  Intercardia  completed an initial public offering of
2,530,000 shares of Intercardia  Common Stock at $15.00 per share,  resulting in
net  proceeds  of  approximately  $35,000,000.  These  proceeds,  along with the
$5,000,000 initial payment received from Astra Merck, increased the total of the
Company's  cash, cash  equivalents  and marketable  securities to $38,016,000 at
June 30, 1996, compared with $1,122,000 at September 30, 1995.

         In connection with its acquisition of CPEC, the Company is committed to
provide certain  support to the BEST Study.  The Company is committed to provide
up to $2,000,000 during the course of the BEST Study, of which $750,000 had been
paid as of June 30, 1996, as well as drug supplies and  monitoring  costs of the
study  expected  to  aggregate  an  additional   $2,500,000.   The  Astra  Merck
Collaboration  provides Astra Merck with U.S.  marketing rights to a twice-daily
formulation  of  bucindolol  and  obligates  Astra  Merck  to fund  future  U.S.
development,  marketing

                                       11

<PAGE>

and manufacturing  costs and to assume the Company's funding  obligation for the
BEST  Study and  royalty  obligation  to  Bristol-Myers  for sales in the United
States.  The Company will receive  royalties  based on net sales by Astra Merck.
The Company has agreed to pay Astra Merck $10,000,000 in December 1997 and up to
$11,000,000  for one-third of product launch costs  incurred  beginning when the
Company files an NDA for the twice-daily  formulation and continuing through the
first 12 months  subsequent to the first commercial sale of the formulation.  In
the event the Company elects not to make these payments,  the royalties  payable
by Astra Merck to the Company will be substantially reduced.

         The  Company  has  invested  approximately  $338,000  in  property  and
equipment,  which  includes  approximately  $176,000 of equipment  under capital
leases.  Approximately  $37,000 of equipment was acquired  under capital  leases
during the nine months ended June 30, 1996. As of June 30, 1996, the Company was
also a party to employment agreements with officers containing minimum aggregate
annual payments of approximately $512,000.

         In March 1996,  Intercardia  amended its  building  lease  agreement to
increase its leased space to approximately  6,200 square feet from approximately
2,500  square  feet and to extend the end of the lease term from May 31, 2000 to
April 30, 2001.  Total future minimum lease payments  increased to approximately
$558,000 at June 30, 1996 from approximately $212,000 at September 30, 1995.

         In April 1996, the Company entered into the Feasibility Study Agreement
and the License  Agreement with Jago. The study  contemplated by the Feasibility
Study  Agreement  is designed to  determine  the  feasibility  of  developing  a
once-daily  formulation  of bucindolol.  The Company made an initial  payment of
$390,000 upon signing the Feasibility  Study  Agreement.  The Feasibility  Study
Agreement  expires  the  earlier of 60 days after  receipt by the Company of the
Preliminary  Pharmacokinetic  Study from Jago, or immediately  upon a default or
breach of confidentiality provisions or upon another breach or default not cured
within 30 days of notice  thereof,  upon bankruptcy of a party or if the Company
determines  in its sole  discretion  not to  proceed  with the next phase of the
study.  The License  Agreement has a perpetual term, but contains similar breach
and bankruptcy  termination  provisions as the Feasibility Study Agreement.  The
Company  will  make  additional  payments  to Jago  if  certain  milestones  are
achieved,  and  will  pay  royalties  to Jago  on net  sales  of the  once-daily
formulation,  if developed under these  agreements,  until the expiration of the
relevant  patent on a  country-by-country  basis  (or 15 years,  if no patent is
issued in that country).

         The Company expects to incur  substantial  additional  costs and losses
over the next few years. The Company's working capital and capital  requirements
will depend upon numerous  factors,  including:  the progress of the development
and clinical trials of bucindolol;  the timing and cost of obtaining  regulatory
approvals;   the  effect  of  competitive   drugs  on  the  BEST  Study  and  on
commercialization  of  bucindolol;  and the ability of the Company to  establish
additional  collaborative  arrangements with other companies to provide research
or development  funding to the Company and to conduct  clinical  trials,  obtain
regulatory  approvals,  and  manufacture  and market  certain  of the  Company's
products.  The Company may acquire other  products,  technologies  or businesses
that  complement  the  Company's  existing  and planned  products,  although the
Company currently has no understanding,  commitment or agreement with respect to

                                       12

<PAGE>

any such  acquisitions.  During  the past  year,  the  Company  has  engaged  in
licensing   discussions  with   pharmaceutical   companies   regarding  possible
relationships for the development and marketing of bucindolol outside the United
States.  The Company expects to enter into such a relationship,  however,  there
can be no assurance that any licensing  agreement will be reached with any third
party.

                                       13

<PAGE>


Part II.          OTHER INFORMATION


Item 6.             Exhibits and Reports on Form 8-K

(a)   Exhibits
      10.21    Intercardia, Inc. 1994 Stock Option Plan, as amended on June 13,
               1996
      11.1     Statement re computation of net income (loss) per share
      27       Financial Data Schedule, which is submitted electronically to the
               Securities and Exchange Commission for information only and 
               not filed.

(b)      No reports on Form 8-K were filed during the period.


                                       14

<PAGE>


                                    SIGNATURE

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                                            INTERCARDIA, INC.



Date:    August 12, 1996    By:     /s/ Richard W. Reichow
                                    ----------------------
                                    Richard W. Reichow,
                                    Senior Vice President,
                                    Chief Financial Officer and Treasurer
                                    (Principal Financial and Accounting Officer)

                                       15



                                                                   EXHIBIT 10.21


                                INTERCARDIA, INC.

                       1994 STOCK OPTION PLAN, AS AMENDED


1.                Purpose.

                  The  purpose  of this  plan  (the  "Plan")  is to  secure  for
INTERCARDIA, INC. (the "Company") and its shareholders the benefits arising from
capital stock ownership by employees, officers and directors of, and consultants
or advisors to, the Company, the Company's parent, Interneuron  Pharmaceuticals,
Inc.  ("Interneuron") and the Company's subsidiary corporations who are expected
to contribute to the Company's  future growth and success.  Those  provisions of
the Plan  which  make  express  reference  to  Section  422 shall  apply only to
Incentive Stock Options (as that term is defined in the Plan).

2.                Type of Options and Administration.

                  (a) Types of  Options.  Options  granted  pursuant to the Plan
shall be  authorized  by action of the Board of  Directors  of the Company (or a
Committee  designated  by the Board of  Directors)  and may be either  incentive
stock options  ("Incentive  Stock Options")  meeting the requirements of Section
422 of the Internal  Revenue Code of 1986,  as amended or replaced  from time to
time (the "Code") or  non-statutory  options  which are not intended to meet the
requirements of Section 422 of the Code.

                  (b) Administration. The Plan will be administered by the Board
of  Directors  or a  committee  (the  "Committee")  appointed  by the  Board  of
Directors of the Company, whose construction and interpretation of the terms and
provisions of the Plan shall be final and  conclusive.  The delegation of powers
to the  Committee  shall  be  consistent  with  applicable  laws or  regulations
(including, without limitation,  applicable state law and Rule 16b-3 promulgated
under the Securities Exchange Act of 1934 (the "Exchange Act"), or any successor
rule ("Rule 16b-3")).  The Committee may in its sole discretion grant options to
purchase  shares  of the  Company's  Common  Stock,  $.001  par  value per share
("Common Stock"),  and issue shares upon exercise of such options as provided in
the Plan. The Committee shall have authority,  subject to the express provisions
of the Plan,  to construe the  respective  option  agreements  and the Plan,  to
prescribe,  amend and rescind  rules and  regulations  relating to the Plan,  to
determine the terms and provisions of the respective  option  agreements,  which
need not be identical,  and to make all other  determinations in the judgment of
the Committee  necessary or desirable for the  administration  of the Plan.  The
Committee  may  correct  any  defect or supply any  omission  or  reconcile  any
inconsistency  in the Plan or in any option  agreement  in the manner and to the
extent it shall deem expedient to carry the Plan into effect and it shall be the
sole and final judge of such  expediency.  No director or person acting pursuant
to authority  delegated by the Board of Directors shall be liable for any action
or  determination  under the Plan made in good faith.  Subject to  adjustment as
provided in Section 15 below,  the  aggregate  number of shares of Common  Stock
that may be

<PAGE>


subject  to options  granted  to any person in a calendar  year shall not exceed
300,000 shares.

                  (c) Applicability of Rule 16b-3.  Those provisions of the Plan
which make  express  reference  to Rule 16b-3 shall apply to the Company only at
such time as the Company's  Common Stock is  registered  under the Exchange Act,
subject to the last sentence of Section  3(b),  and then only to such persons as
are  required  to file  reports  under  Section  16(a)  of the  Exchange  Act (a
"Reporting Person").

3.                Eligibility.

                  (a) General. Options may be granted to persons who are, at the
time of grant,  employees,  officers or directors of, or consultants or advisors
to, the Company,  Interneuron,  or any subsidiaries of the Company as defined in
Sections 424(e) and 424(f) of the Code ("Participants") provided, that Incentive
Stock  Options  may only be  granted to  individuals  who are  employees  of the
Company  (within the meaning of Section  3401(c) of the Code).  A person who has
been  granted an option  may,  if he or she is  otherwise  eligible,  be granted
additional options if the Committee shall so determine.

                  (b) Grant of Options to Reporting Persons.  The selection of a
director or an officer who is a Reporting  Person (as the terms  "director"  and
"officer"  are defined for  purposes of Rule 16b-3) as a recipient of an option,
the timing of the option grant,  the exercise price of the option and the number
of shares  subject to the option shall be determined  either (i) by the Board of
Directors, of which all members shall be "disinterested persons" (as hereinafter
defined),  (ii) by a committee  consisting of two or more directors  having full
authority to act in the matter,  each of whom shall be a "disinterested  person"
or (iii) pursuant to provisions  for automatic  grants set forth in Section 3(c)
below.  For the  purposes  of the  Plan,  a  director  shall be  deemed  to be a
"disinterested person" only if such person qualifies as a "disinterested person"
within the meaning of Rule 16b-3, as such term is interpreted from time to time.
If at least two of the  members of the Board of  Directors  do not  qualify as a
"disinterested  person"  within  the  meaning  of Rule  16b-3,  as such  term is
interpreted  from time to time,  then the  granting of options to  officers  and
directors  who are  Reporting  Persons under the Plan shall not be determined in
accordance with this Section 3(b) but shall be determined in accordance with the
other provisions of the Plan.

                  (c)  Directors'  Options.  On the date on which the  Company's
registration  statement  relating  to its  initial  public  offering is declared
effective by the  Securities  and Exchange  Commission  (the  "Effective  Date")
directors of the Company who are not employees or beneficial  owners of at least
10% of the voting power of the Company's securities ("Eligible  Directors") will
receive an option  ("Initial  Director  Option")  to purchase  10,000  shares of
Common  Stock.  Future  Eligible  Directors  of the  Company  will be granted an
Initial  Director  Option to purchase  5,000  shares of Common Stock on the date
that such person is first elected or appointed a director. Commencing on the day
immediately  following the date of the annual  meeting of  stockholders  for the
Company's  fiscal year ending after the fiscal year in which the Effective  Date
occurs,  each  Eligible  Director  will receive an automatic  grant  ("Automatic
Grant")  of an Option

                                       2

<PAGE>

to purchase  3,000 shares of Common  Stock,  other than  Eligible  Directors who
received an Initial  Director Option since the most recent  Automatic  Grant, on
the day immediately  following the date of each annual meeting of  stockholders,
as long as such  director is a member of the Board of  Directors.  The  exercise
price for each share  subject to a  Director  Option  shall be equal to the fair
market value of the Common Stock on the date of grant.  Director  Options  shall
become  exercisable in 36 equal monthly  installments  commencing one month from
the date the option is granted and will expire the earlier of 10 years after the
date of grant or 90 days after the termination of the director's  service on the
Board.

4.                Stock Subject to Plan.

                  The stock  subject to options  granted under the Plan shall be
shares of  authorized  but  unissued  or  reacquired  Common  Stock.  Subject to
adjustment  as  provided in Section 15 below,  the  maximum  number of shares of
Common  Stock of the  Company  which  may be issued  and sold  under the Plan is
1,500,000.  If an option  granted under the Plan shall  expire,  terminate or is
cancelled for any reason without having been exercised in full, the  unpurchased
shares  subject to such option shall again be available  for  subsequent  option
grants under the Plan.

5.                Forms of Option Agreements.

                  As a condition to the grant of an option under the Plan,  each
recipient  of an  option  shall  execute  an option  agreement  in such form not
inconsistent  with the Plan as may be approved by the Board of  Directors.  Such
option agreements may differ among recipients.

6.                Purchase Price.

                  (a) General. The purchase price per share of stock deliverable
upon the exercise of an option shall be  determined by the Board of Directors or
the Committee at the time of grant of such option;  provided,  however,  that in
the case of an Incentive Stock Option, the exercise price shall not be less than
100% of the Fair Market  Value (as  hereinafter  defined) of such stock,  at the
time of grant of such option, or less than 110% of such Fair Market Value in the
case of options  described in Section  11(b).  "Fair Market Value" of a share of
Common Stock of the Company as of a specified  date for the purposes of the Plan
shall mean the  closing  price of a share of the Common  Stock on the  principal
securities  exchange (including the Nasdaq National Market) on which such shares
are traded on the day  immediately  preceding  the date as of which Fair  Market
Value is being  determined,  or on the next  preceding date on which such shares
are traded if no shares were traded on such immediately preceding day, or if the
shares are not traded on a  securities  exchange,  Fair  Market  Value  shall be
deemed to be the  average of the high bid and low asked  prices of the shares in
the  over-the-counter  market on the day  immediately  preceding  the date as of
which Fair Market Value is being  determined  or on the next  preceding  date on
which such high bid and low asked  prices were  recorded.  If the shares are not
publicly traded, Fair Market Value of a share of Common Stock (including, in the
case of any repurchase of shares,  any distributions  with respect thereto which
would be  repurchased  with the shares) shall

                                       3

<PAGE>


be  determined  in good faith by the Board of  Directors.  In no case shall Fair
Market Value be determined with regard to restrictions  other than  restrictions
which, by their terms, will never lapse.

                  (b) Payment of Purchase Price.  Options granted under the Plan
may provide for the payment of the exercise price by delivery of cash or a check
to the order of the  Company in an amount  equal to the  exercise  price of such
options,  or by any other  means  which the Board of  Directors  determines  are
consistent with the purpose of the Plan and with applicable laws and regulations
(including,  without  limitation,  the provisions of Rule 16b-3 and Regulation T
promulgated by the Federal Reserve Board).

7.                Option Period.

                  Subject to earlier  termination as provided in the Plan,  each
option and all rights  thereunder shall expire on such date as determined by the
Board of  Directors  or the  Committee  and set forth in the  applicable  option
agreement, provided, that such date shall not be later than (10) ten years after
the date on which the option is granted.

8.                Exercise of Options.

                  Each option granted under the Plan shall be exercisable either
in full or in installments at such time or times and during such period as shall
be set forth in the option  agreement  evidencing  such  option,  subject to the
provisions of the Plan. No option granted to a Reporting  Person for purposes of
the Exchange  Act,  however,  shall be  exercisable  during the first six months
after  the  date  of  grant.  Subject  to the  requirements  in the  immediately
preceding  sentence,  if an  option  is not at the  time  of  grant  immediately
exercisable,  the Board of Directors  may (i) in the agreement  evidencing  such
option,  provide  for the  acceleration  of the  exercise  date or  dates of the
subject option upon the occurrence of specified events,  and/or (ii) at any time
prior to the complete termination of an option,  accelerate the exercise date or
dates of such option.

9.                Nontransferability of Options.

                  No option  granted  under  this Plan  shall be  assignable  or
otherwise  transferable by the optionee except by will or by the laws of descent
and distribution or pursuant to a qualified  domestic relations order as defined
in the Code or Title I of the Employee  Retirement  Income  Security Act, or the
rules thereunder. An option may be exercised during the lifetime of the optionee
only by the optionee. In the event an optionee dies during his employment by the
Company or any of its subsidiaries,  or during the three-month  period following
the date of  termination  of such  employment,  his option shall  thereafter  be
exercisable,  during  the  period  specified  in the  option  agreement,  by his
executors  or  administrators  to the full  extent  to  which  such  option  was
exercisable  by the  optionee  at the time of his death  during the  periods set
forth in Section 10 or 11(d).

                                       4

<PAGE>

10.               Effect of Termination of Employment or Other Relationship.

                  Except as provided in Section  11(d) with respect to Incentive
Stock Options and except as otherwise determined by the Committee at the date of
grant of an option,  and subject to the  provisions of the Plan, an optionee may
exercise an option at any time within three (3) months following the termination
of the optionee's  employment or other  relationship  with the Company or within
one (1)  year if such  termination  was due to the  death or  disability  of the
optionee but, except in the case of the optionee's death, in no event later than
the  expiration  date  of the  option.  If  the  termination  of the  optionee's
employment is for cause or is otherwise attributable to a breach by the optionee
of an employment or  confidentiality  or  non-disclosure  agreement,  the option
shall expire  immediately  upon such  termination.  The Board of Directors shall
have the power to determine what constitutes a termination for cause or a breach
of an employment or  confidentiality  or  non-disclosure  agreement,  whether an
optionee has been  terminated  for cause or has breached such an agreement,  and
the date upon  which  such  termination  for cause or  breach  occurs.  Any such
determinations shall be final and conclusive and binding upon the optionee.

11.               Incentive Stock Options.

                  Options  granted  under  the Plan  which  are  intended  to be
Incentive Stock Options shall be subject to the following  additional  terms and
conditions:

                  (a) Express  Designation.  All Incentive Stock Options granted
under the Plan shall, at the time of grant,  be specifically  designated as such
in the option agreement covering such Incentive Stock Options.

                  (b) 10%  Stockholder.  If any  employee  to whom an  Incentive
Stock  Option  is to be  granted  under the Plan is, at the time of the grant of
such option,  the owner of stock  possessing more than 10% of the total combined
voting power of all classes of stock of the Company  (after  taking into account
the attribution of stock  ownership  rules of Section 424(d) of the Code),  then
the following  special  provisions  shall be  applicable to the Incentive  Stock
Option granted to such individual:

                        (i) The  purchase  price per share of the  Common  Stock
                  subject to such Incentive  Stock Option shall not be less than
                  110% of the Fair Market  Value of one share of Common Stock at
                  the time of grant; and

                       (ii) the option  exercise  period  shall not exceed  five
                  years from the date of grant.

                  (c)  Dollar  Limitation.  For so long  as the  Code  shall  so
provide, options granted to any employee under the Plan (and any other incentive
stock option plans of the Company)  which are intended to  constitute  Incentive
Stock Options shall not  constitute  Incentive  Stock Options to the extent that
such options, in the aggregate, become exercisable for the first

                                       5

<PAGE>


time in any one calendar year for shares of Common Stock with an aggregate  Fair
Market  Value,  as of the  respective  date or  dates  of  grant,  of more  than
$100,000.

                  (d)  Termination  of  Employment,   Death  or  Disability.  No
Incentive  Stock Option may be exercised  unless,  at the time of such exercise,
the optionee is, and has been continuously since the date of grant of his or her
option, employed by the Company, except that:

                        (i) an Incentive  Stock  Option may be exercised  within
                  the period of three months after the date the optionee  ceases
                  to be an employee of the Company (or within such lesser period
                  as  may be  specified  in the  applicable  option  agreement),
                  provided,  that the agreement  with respect to such option may
                  designate a longer exercise period and that the exercise after
                  such three-month  period shall be treated as the exercise of a
                  non-statutory option under the Plan;

                       (ii) if the  optionee  dies  while in the  employ  of the
                  Company,  or within three months after the optionee  ceases to
                  be  such  an  employee,  the  Incentive  Stock  Option  may be
                  exercised by the person to whom it is  transferred  by will or
                  the laws of descent and distribution  within the period of one
                  year after the date of death (or within such lesser  period as
                  may be specified in the applicable option agreement); and

                      (iii) if the optionee becomes disabled (within the meaning
                  of Section  22(e)(3) of the Code or any  successor  provisions
                  thereto)  while in the employ of the  Company,  the  Incentive
                  Stock  Option may be  exercised  within the period of one year
                  after  the date the  optionee  ceases  to be such an  employee
                  because of such  disability  (or within such lesser  period as
                  may be specified in the applicable option agreement).

For all  purposes  of the Plan and any option  granted  hereunder,  "employment"
shall be defined in accordance with the provisions of Section  1.421-7(h) of the
Income Tax  Regulations  (or any  successor  regulations).  Notwithstanding  the
foregoing  provisions,  no Incentive  Stock  Option may be  exercised  after its
expiration date.

12.               Additional Provisions.

                  (a) Additional  Option  Provisions.  The Board of Directors or
the Committee  may, in its sole  discretion,  include  additional  provisions in
option  agreements  covering options granted under the Plan,  including  without
limitation restrictions on transfer, repurchase rights, rights of first refusal,
commitments  to pay cash bonuses,  to make,  arrange for or guaranty loans or to
transfer  other  property to optionees  upon exercise of options,  or such other
provisions as shall be determined by the Board of Directors; provided, that such
additional provisions shall not be inconsistent with any other term or condition
of the Plan and such additional  provisions  shall not cause any Incentive Stock
Option  granted  under the Plan to fail to qualify as an Incentive  Stock

                                       7

<PAGE>

Option within the meaning of Section 422 of the Code.

                  (b) Acceleration,  Extension, Etc. The Board of Directors may,
in its sole  discretion,  (i)  accelerate  the date or dates on which all or any
particular  option or options  granted  under the Plan may be  exercised or (ii)
extend the dates during which all, or any particular,  option or options granted
under the Plan may be exercised; provided, however, that no such extension shall
be  permitted  if it would cause the Plan to fail to comply with  Section 422 of
the Code or with Rule 16b-3 (if applicable).

13.               General Restrictions.

                  (a)  Investment  Representations.  The Company may require any
person to whom an option is granted, as a condition of exercising such option or
award,  to give written  assurances  in substance and form  satisfactory  to the
Company to the effect that such person is acquiring  the Common Stock subject to
the option or award,  for his or her own account for investment and not with any
present  intention of selling or otherwise  distributing  the same,  and to such
other effects as the Company deems  necessary or  appropriate in order to comply
with  federal  and  applicable  state  securities  laws,  or with  covenants  or
representations  made by the Company in connection  with any public  offering of
its  Common   Stock,   including   any   "lock-up"  or  other   restriction   on
transferability.

                  (b)  Compliance  With  Securities  Law.  Each option  shall be
subject to the  requirement  that if, at any time,  counsel to the Company shall
determine that the listing,  registration or qualification of the shares subject
to such  option or award upon any  securities  exchange or  automated  quotation
system or under any state or federal  law,  or the  consent or  approval  of any
governmental   or  regulatory   body,  or  that  the  disclosure  of  non-public
information  or the  satisfaction  of any  other  condition  is  necessary  as a
condition  of,  or in  connection  with  the  issuance  or  purchase  of  shares
thereunder,  such  option  or award may not be  exercised,  in whole or in part,
unless  such  listing,  registration,  qualification,  consent or  approval,  or
satisfaction  of  such  condition  shall  have  been  effected  or  obtained  on
conditions acceptable to the Board of Directors or the Committee. Nothing herein
shall be deemed to require the  Company to apply for or to obtain such  listing,
registration or qualification, or to satisfy such condition.

14.               Rights as a Stockholder.

                  The holder of an option shall have no rights as a  stockholder
with respect to any shares covered by the option (including, without limitation,
any rights to receive dividends or non-cash  distributions  with respect to such
shares)  until the date of issue of a stock  certificate  to him or her for such
shares.  No adjustment shall be made for dividends or other rights for which the
record date is prior to the date such stock certificate is issued.

15.               Adjustment Provisions for Recapitalizations, Reorganizations
                  and Related Transactions.

                                       7

<PAGE>


                  (a) Recapitalizations and Related Transactions. If, through or
as a result of any  recapitalization,  reclassification,  stock dividend,  stock
split,  reverse stock split or other similar  transaction,  (i) the  outstanding
shares of Common Stock are  increased,  decreased  or exchanged  for a different
number or kind of shares or other securities of the Company,  or (ii) additional
shares or new or different  shares or other non-cash assets are distributed with
respect to such shares of Common Stock or other  securities,  an appropriate and
proportionate  adjustment  shall be made in (x) the  maximum  number and kind of
shares reserved for issuance under or otherwise referred to in the Plan, (y) the
number and kind of shares or other  securities  subject to any then  outstanding
options  under the Plan,  and (z) the price for each  share  subject to any then
outstanding  options under the Plan,  without  changing the  aggregate  purchase
price  as  to  which  such  options  remain  exercisable.   Notwithstanding  the
foregoing,  no  adjustment  shall be made  pursuant  to this  Section 15 if such
adjustment  (i) would cause the Plan to fail to comply  with  Section 422 of the
Code or with Rule 16b-3 or (ii) would be  considered  as the  adoption  of a new
plan requiring stockholder approval.

                  (b)  Reorganization,  Merger  and  Related  Transactions.  All
outstanding  options under the Plan shall become fully  exercisable for a period
of sixty (60) days following the occurrence of any Trigger Event, whether or not
such  options  are then  exercisable  under  the  provisions  of the  applicable
agreements relating thereto.  For purposes of the Plan, a "Trigger Event" is any
one of the following events :

                           (i) the date on which  shares  of  Common  Stock  are
         first  purchased  pursuant to a tender  offer or exchange  offer (other
         than such an offer by the Company,  any  Subsidiary,  Interneuron,  any
         employee benefit plan of the Company or of any Subsidiary or any entity
         holding  shares or other  securities  of the Company for or pursuant to
         the terms of such  plan),  whether  or not such  offer is  approved  or
         opposed by the Company and regardless of the number of shares purchased
         pursuant to such offer;

                           (ii) the date the Company acquires knowledge that any
         person or group deemed a person under  Section  13(d)-3 of the Exchange
         Act (other than the Company,  Interneuron, any Subsidiary, any employee
         benefit plan of the Company or of any  Subsidiary or any entity holding
         shares  of  Common  Stock or other  securities  of the  Company  for or
         pursuant to the terms of any such plan or any  individual  or entity or
         group or affiliate  thereof  which  acquired its  beneficial  ownership
         interest  prior to the date the Plan was  adopted by the  Board),  in a
         transaction or series of transactions, has become the beneficial owner,
         directly  or  indirectly  (with  beneficial   ownership  determined  as
         provided in Rule 13d-3, or any successor rule, under the Exchange Act),
         of  securities  of the Company  entitling the person or group to 30% or
         more of all votes (without  consideration of the rights of any class or
         stock  to elect  directors  by a  separate  class  vote)  to which  all
         stockholders  of the Company  would be entitled in the  election of the
         Board of Directors were an election held on such date;


                                       8

<PAGE>
                           (iii) the date,  during any period of two consecutive
         years,  when individuals who at the beginning of such period constitute
         the  Board  of  Directors  of the  Company  cease  for  any  reason  to
         constitute at least a majority  thereof,  unless the  election,  or the
         nomination for election by the stockholders of the Company, of each new
         director was approved by a vote of at least two-thirds of the directors
         then  still in  office  who were  directors  at the  beginning  of such
         period; and

                           (iv) the date of approval by the  stockholders of the
         Company of an agreement (a "reorganization agreement") providing for:

                                    (A)  The  merger  of  consolidation  of  the
                  Company with another corporation where the stockholders of the
                  Company, immediately prior to the merger or consolidation,  do
                  not  beneficially   own,   immediately  after  the  merger  or
                  consolidation,  shares  of the  corporation  issuing  cash  or
                  securities  in the  merger  or  consolidation  entitling  such
                  stockholders   to  80%  or   more   of  all   votes   (without
                  consideration  of the  rights  of any  class of stock to elect
                  directors by a separate class vote) to which all  stockholders
                  of such  corporation  would be  entitled  in the  election  of
                  directors  or where the members of the Board of  Directors  of
                  the Company, immediately prior to the merger or consolidation,
                  do  not,   immediately  after  the  merger  or  consolidation,
                  constitute  a  majority  of  the  Board  of  Directors  of the
                  corporation  issuing  cash  or  securities  in the  merger  or
                  consolidation; or

                                    (B) The sale or other  disposition of all or
                  substantially all the assets of the Company.

                  (c) Board Authority to Make Adjustments. Any adjustments under
this Section 15 will be made by the Board of Directors or the  Committee,  whose
determination  as to what  adjustments,  if any,  will  be made  and the  extent
thereof will be final,  binding and  conclusive.  No  fractional  shares will be
issued under the Plan on account of any such adjustments.

16.               Merger, Consolidation, Asset Sale, Liquidation, etc.

                  (a)  General.  In the event of any sale,  merger,  transfer or
acquisition of the Company or substantially  all of the assets of the Company in
which the Company is not the surviving corporation,  and provided that after the
Company shall have  requested the  acquiring or  succeeding  corporation  (or an
affiliate  thereof),  that  equivalent  options  shall be  substituted  and such
successor  corporation  shall  have  refused  or failed to  assume  all  options
outstanding under the Plan or issue substantially  equivalent options,  then any
or  all  outstanding   options  under  the  Plan  shall  accelerate  and  become
exercisable in full  immediately  prior to such event. The Committee will notify
holders  of  options  under  the  Plan  that  any  such  options  shall be fully
exercisable for a period of fifteen (15) days from the date of such notice,  and
the options will terminate upon expiration of such notice.

                                       9

<PAGE>

                  (b)  Substitute  Options.  The Company may grant options under
the Plan in  substitution  for options held by employees of another  corporation
who  become  employees  of the  Company,  Interneuron,  or a  subsidiary  of the
Company,  Interneuron,  as  the  result  of a  merger  or  consolidation  of the
employing  corporation  with  the  Company  or  a  subsidiary  of  the  Company,
Interneuron,  or as a result of the acquisition by the Company,  Interneuron, or
one of its subsidiaries,  of property or stock of the employing corporation. The
Company  may  direct  that  substitute  options  be  granted  on such  terms and
conditions as the Board of Directors considers appropriate in the circumstances.

17.               No Special Employment Rights.

                  Nothing  contained  in the Plan or in any option  shall confer
upon any  optionee  any right  with  respect to the  continuation  of his or her
employment  by the Company or interfere in any way with the right of the Company
at any  time to  terminate  such  employment  or to  increase  or  decrease  the
compensation of the optionee.

18.               Other Employee Benefits.

                  Except as to plans which by their terms  include  such amounts
as  compensation,  the amount of any  compensation  deemed to be  received by an
employee as a result of the exercise of an option or the sale of shares received
upon such exercise will not  constitute  compensation  with respect to which any
other  employee  benefits of such employee are  determined,  including,  without
limitation, benefits under any bonus, pension, profit-sharing, life insurance or
salary  continuation  plan, except as otherwise  specifically  determined by the
Board of Directors.

19.                Amendment of the Plan.

                  (a) The Board of Directors  may at any time,  and from time to
time, modify or amend the Plan in any respect; provided, however, that if at any
time the approval of the  stockholders  of the Company is required under Section
422 of the Code or any  successor  provision  with  respect to  Incentive  Stock
Options,  or under  Rule  16b-3,  the Board of  Directors  may not  effect  such
modification or amendment without such approval; and provided, further, that the
provisions  of Section 3(c) hereof shall not be amended more than once every six
months,  other than to comport with changes in the Code, the Employer Retirement
Income Security Act of 1974, as amended, or the rules thereunder.

                  (b) The  modification  or  amendment  of the Plan  shall  not,
without the  consent of an  optionee,  affect his or her rights  under an option
previously granted to him or her. With the consent of the optionee affected, the
Board of Directors or the Committee may amend outstanding option agreements in a
manner not  inconsistent  with the Plan.  The Board of Directors  shall have the
right to amend or modify  (i) the terms  and  provisions  of the Plan and of any
outstanding  Incentive  Stock  Options  granted  under  the  Plan to the  extent
necessary to qualify any or all such options for such  favorable  federal income
tax treatment  (including deferral of

                                       10

<PAGE>

taxation upon exercise) as may be afforded incentive stock options under Section
422 of the  Code  and  (ii)  the  terms  and  provisions  of the Plan and of any
outstanding  option to the extent  necessary to ensure the  qualification of the
Plan under Rule 16b-3.


20.               Withholding.

                  (a) The Company  shall have the right to deduct from  payments
of any kind  otherwise due to the optionee any federal,  state or local taxes of
any kind  required by law to be withheld  with respect to any shares issued upon
exercise  of  options  under the Plan.  Subject  to the  prior  approval  of the
Company,  which may be  withheld  by the  Company  in its sole  discretion,  the
optionee  may elect to satisfy  such  obligations,  in whole or in part,  (i) by
causing  the  Company to  withhold  shares of Common  Stock  otherwise  issuable
pursuant  to the  exercise  of an option or (ii) by  delivering  to the  Company
shares of Common Stock already owned by the optionee. The shares so delivered or
withheld shall have a Fair Market Value equal to such withholding  obligation as
of the date  that the  amount  of tax to be  withheld  is to be  determined.  An
optionee  who has made an  election  pursuant  to this  Section  20(a)  may only
satisfy his or her withholding  obligation with shares of Common Stock which are
not subject to any repurchase,  forfeiture, unfulfilled vesting or other similar
requirements.

                  (b) The  acceptance of shares of Common Stock upon exercise of
an Incentive  Stock Option shall  constitute an agreement by the optionee (i) to
notify the Company if any or all of such shares are  disposed of by the optionee
within two years  from the date the  option was  granted or within one year from
the date the shares were issued to the optionee  pursuant to the exercise of the
option, and (ii) if required by law, to remit to the Company, at the time of and
in the case of any  such  disposition,  an  amount  sufficient  to  satisfy  the
Company's  federal,  state and local withholding tax obligations with respect to
such  disposition,  whether or not, as to both (i) and (ii),  the optionee is in
the employ of the Company at the time of such disposition.

                  (c) Notwithstanding the foregoing,  in the case of a Reporting
Person whose  options have been granted in  accordance  with the  provisions  of
Section  3(b) herein,  no election to use shares for the payment of  withholding
taxes  shall  be  effective  unless  made  in  compliance  with  any  applicable
requirements of Rule 16b-3.

21.               Cancellation and New Grant of Options, Etc.

                  The  Board  of  Directors  or the  Committee  shall  have  the
authority to effect,  at any time and from time to time, with the consent of the
affected optionees, (i) the cancellation of any or all outstanding options under
the Plan and the grant in  substitution  therefor of new options  under the Plan
covering the same or  different  numbers of shares of Common Stock and having an
option  exercise  price per share which may be lower or higher than the exercise
price per share of the  cancelled  options or (ii) the amendment of the terms of
any and all  outstanding  options  under the Plan to provide an option  exercise
price per share which is higher or lower than the  then-current  exercise  price
per share of such outstanding options.

22.               Effective Date and Duration of the Plan.

                                       11

<PAGE>

                  (a)  Effective  Date.  The Plan shall  become  effective  when
adopted by the Board of Directors,  but no Incentive  Stock Option granted under
the Plan  shall  become  exercisable  unless  and until the Plan shall have been
approved by the  Company's  stockholders.  If such  stockholder  approval is not
obtained  within  twelve  months  after the date of the Board's  adoption of the
Plan,  no  options  previously  granted  under  the Plan  shall be  deemed to be
Incentive  Stock  Options  and no  Incentive  Stock  Options  shall  be  granted
thereafter.  Amendments to the Plan not  requiring  stockholder  approval  shall
become  effective when adopted by the Board of Directors;  amendments  requiring
stockholder  approval (as provided in Section 19) shall  become  effective  when
adopted by the Board of Directors,  but no Incentive  Stock Option granted after
the date of such  amendment  shall become  exercisable  (to the extent that such
amendment to the Plan was required to enable the Company to grant such Incentive
Stock Option to a particular  optionee)  unless and until such  amendment  shall
have been approved by the Company's  stockholders.  If such stockholder approval
is not obtained within twelve months of the Board's  adoption of such amendment,
any Incentive Stock Options granted on or after the date of such amendment shall
terminate  to the extent that such  amendment to the Plan was required to enable
the  Company  to grant such  option to a  particular  optionee.  Subject to this
limitation,  options  may be  granted  under  the  Plan at any  time  after  the
effective date and before the date fixed for termination of the Plan.

                  (b) Termination.  Unless sooner  terminated in accordance with
Section  16,  the Plan  shall  terminate  upon the  earlier  of (i) the close of
business  on the day next  preceding  the tenth  anniversary  of the date of its
adoption  by the  Board of  Directors,  or (ii) the  date on  which  all  shares
available  for  issuance  under the Plan shall have been issued  pursuant to the
exercise  or  cancellation  of options  granted  under the Plan.  If the date of
termination is determined under (i) above, then options outstanding on such date
shall continue to have force and effect in accordance with the provisions of the
instruments evidencing such options.

23.               Governing Law.

                  The provisions of this Plan shall be governed and construed in
accordance  with  the  laws of the  State  of  Delaware  without  regard  to the
principles of conflicts of laws.

                  Adopted by the Board of  Directors on October 31, 1994 Amended
                  by the Board of  Directors  on October  27,  1995 and June 13,
                  1996.

                                       11

<PAGE>



EXHIBIT 11.1

                                INTERCARDIA, INC.

             STATEMENT RE COMPUTATION OF NET INCOME (LOSS) PER SHARE
                  (Dollars in thousands, except per share data)



<TABLE>
<CAPTION>
                                                      Three Months Ended                         Nine Months Ended
                                                           June 30,                                  June 30,
                                             -------------------------------------     --------------------------------------
                                                   1996                1995                  1996                1995
                                             -----------------     -----------------   ------------------  ------------------
<S>                                           <C>                 <C>                   <C>                 <C>  
Net Income (Loss) per Unaudited
Consolidated Statements of Operations         $         (777)     $     (705)           $         2,068     $        (1,288)
                                             =================   =================     =================   ==================

Calculation of Weighted Average
       Number of Common Shares and
       Common Share Equivalents:
           Common Stock                             6,726,621           3,500,000             5,273,114            3,500,000
           Series A Preferred Stock                                       692,621 (1)           312,060              692,621 (1)
           Stock Options and Warrants                                     681,826 (2)           227,275              681,826 (2)
                                             -----------------   -----------------     -----------------   ------------------
                                                    6,726,621           4,874,447             5,812,449            4,874,447
                                             =================   =================     =================   ==================
Net Income (Loss) per Common Share            $        (0.12)     $        (0.14)       $          0.36     $         (0.26)
                                             =================   =================     =================   ==================

</TABLE>


- --------------
(1)      All of the Series A Preferred shares were issued within one year of the
         initial filing date of  Intercardia's  initial public  offering and are
         therefore  treated as outstanding in accordance  with Staff  Accounting
         Bulletin Topic 4-D.

(2)      Includes  stock  options and  warrants  granted  within one year of the
         initial filing date of Intercardia's initial public offering, which are
         treated as outstanding  in accordance  with Staff  Accounting  Bulletin
         Topic 4-D. The amount is net of 60,882 shares that would be repurchased
         under the treasury stock method.

<PAGE>


<TABLE> <S> <C>

<ARTICLE>  5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE 
CONSOLIDATED BALANCE SHEET AND THE CONSOLIDATED STATEMENT OF INCOME FILED AS 
PART OF THE QUARTERLY REPORT ON FORM 10-Q AND IS QUALIFIED IN ITS
ENTIRETY BY REFERENCE TO SUCH QUARTERLY REPORT ON FORM 10-Q.
</LEGEND>
<MULTIPLIER>  1,000
       
<S>                                         <C>
<PERIOD-TYPE>                       9-MOS
<FISCAL-YEAR-END>                                               SEP-30-1996
<PERIOD-START>                                                  OCT-01-1995
<PERIOD-END>                                                    JUN-30-1996
<CASH>                                                               20,102
<SECURITIES>                                                         16,895
<RECEIVABLES>                                                         1,621
<ALLOWANCES>                                                              0
<INVENTORY>                                                               0
<CURRENT-ASSETS>                                                     38,746
<PP&E>                                                                  285
<DEPRECIATION>                                                            0
<TOTAL-ASSETS>                                                       40,058
<CURRENT-LIABILITIES>                                                 2,380
<BONDS>                                                                 118
                                                     0
                                                               0
<COMMON>                                                                  7
<OTHER-SE>                                                          36,921
<TOTAL-LIABILITY-AND-EQUITY>                                         40,058
<SALES>                                                                   0
<TOTAL-REVENUES>                                                      5,835
<CGS>                                                                     0
<TOTAL-COSTS>                                                             0
<OTHER-EXPENSES>                                                          0
<LOSS-PROVISION>                                                          0
<INTEREST-EXPENSE>                                                        0
<INCOME-PRETAX>                                                       2,068
<INCOME-TAX>                                                              0
<INCOME-CONTINUING>                                                   2,068
<DISCONTINUED>                                                            0
<EXTRAORDINARY>                                                           0
<CHANGES>                                                                 0
<NET-INCOME>                                                          2,068
<EPS-PRIMARY>                                                           .36
<EPS-DILUTED>                                                           .36
        

</TABLE>


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