INTERCARDIA INC
S-8, 1996-09-27
PHARMACEUTICAL PREPARATIONS
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  As filed with the Securities and Exchange Commission on September 27, 1996.
                                                Registration No. 33-___________


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                ----------------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                     under
                           THE SECURITIES ACT OF 1933

                               Intercardia, Inc.
               (Exact name of issuer as specified in its charter)

           Delaware                                          56-1924222
(State or other jurisdiction of                           (I.R.S. Employer
incorporation or organization)                          Identification Number)

              3200 East Highway 54, Cape Fear Building, Suite 300
                 Research Triangle Park, North Carolina  27709
              (Address of Principal Executive Offices) (Zip Code)

                             1994 Stock Option Plan
                       1995 Employee Stock Purchase Plan
                           (Full title of the plans)

                               Clayton I. Duncan
                     President and Chief Executive Officer
                               Intercardia, Inc.
                                 P.O. Box 14287
                              3200 East Highway 54
                         Cape Fear Building, Suite 300
                  Research Triangle Park, North Carolina 27709
                    (Name and address of agent for service)

                                 (919) 558-8688
         (Telephone number, including area code, of agent for service)



                                   Copies to:
                            Donald R. Reynolds, Esq.
                        Wyrick, Robbins, Yates & Ponton
                        4101 Lake Boone Trail, Suite 300
                         Raleigh, North Carolina 27607
                                 (919) 781-4000


                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
============================================================================================
   Title of                         Proposed maximum   Proposed maximum
securities to        Amounts to      offering price       aggregate           Amount of
be registered       be registered      per share*      offering price*     registration fee
============================================================================================
<S> <C>
Common Stock,
par value
$0.001 per share  1,600,000 shares      $20.125           $32,200,000        $ 11,103.45
                                         -------          -----------           --------
============================================================================================
</TABLE>

*Estimated solely for the purpose of calculating the registration fee pursuant
 to Rule 457(c), based on the average of the high and low prices for the Common
 Stock on the NASDAQ  National  Market  System on September 23, 1996.


<PAGE>

                                    PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


Item 3.           Incorporation of Documents by Reference

         The following  documents  heretofore  filed by  Intercardia,  Inc. (the
"Company") with the Securities and Exchange  Commission (the  "Commission")  are
incorporated herein by reference:

         (a) The Company's  prospectus dated February 1, 1996, filed pursuant to
Rule 424(b) promulgated under the Securities Act of 1933, as amended;

         (b) The Company's Quarterly Reports on Form 10-Q for the quarters ended
December 31, 1995, March 31, 1996 (as amended) and June 30, 1996, filed pursuant
to Section 13 of the Securities  Exchange Act of 1934, as amended (the "Exchange
Act"); and

         (c) The  description  of the  Company's  Common Stock  contained in the
Company's Registration Statement on Form 8-A filed pursuant to Section 12 of the
Exchange Act on December 8, 1995,  including  any  amendment or report filed for
the purpose of updating such description.

         All documents filed by the Company  pursuant to Sections 13(a),  13(c),
14 or 15(d) of the Exchange Act after the date hereof and prior to the filing of
a post-effective amendment that indicates that all securities offered under this
registration  statement have been sold or that  deregisters  all securities then
remaining unsold,  shall be deemed to be incorporated by reference herein and to
be part hereof from the date of filing of such documents.

         Any statement contained in a document  incorporated by reference herein
shall be deemed to be modified or superseded  for purposes  hereof to the extent
that a statement  contained herein (or in any other  subsequently filed document
that also is or is deemed to be  incorporated by reference  herein)  modifies or
supersedes such statement.  Any statement so modified or superseded shall not be
deemed to constitute a part hereof except as so modified or superseded.

Item 4.           Description of Securities

         Not  applicable.  The class of  securities  to be offered is registered
under Section 12 of the Exchange Act.

Item 5.           Interests of Named Experts and Counsel

         Not applicable.


Item 6.           Indemnification of Directors and Officers

         The Company's  Amended and Restated  Certificate of  Incorporation  and
Amended and Restated  Bylaws  include  provisions  to (i) eliminate the personal
liability of its directors for monetary damages resulting from breaches of their
fiduciary  duty to the fullest  extent  permitted by Section 145 of the Delaware
General  Corporation  Law (the  "Delaware  Law") and (ii) require the Company to
indemnify its directors and officers to the fullest extent  permitted by Section
145 of the Delaware Law,  including  circumstances in which  indemnification  is
otherwise  discretionary.  Pursuant  to  Section  145 of  the  Delaware  Law,  a
corporation  generally  has the  power  to  indemnify  its  present  and  former
directors, officers, employees and agents against expenses incurred
by them in connection  with any suit to which they are, or are


<PAGE>

threatened to be made, a party by reason of their serving in such positions so
long as they acted in good faith and in a manner they reasonably  believed to be
in, or not opposed to, the best  interests  of the  corporation,  and with
respect to any criminal action, they had no reasonable cause to believe their
conduct was unlawful.  The Company  believes  that these  provisions  are
necessary  to attract and retain qualified  persons as directors and officers.
These provisions do not eliminate the  directors'  duty of care,  and,  in
appropriate  circumstances,  equitable remedies such as injunctive  or other
forms of  non-monetary  relief will remain available  under  Delaware  Law. In
addition,  each director will continue to be subject  to  liability  for  breach
of the  director's  duty of  loyalty  to the Company,  if acts  or  omissions
not in good  faith  or  involving  intentional misconduct or knowing violations
of law, for acts or omissions that the director believes  to  be  contrary  to
the  best   interests  of  the  Company  or  its stockholders,  for any
transaction  from which the director  derived an improper personal benefit,  for
acts or omissions  involving a reckless disregard for the director's duty to the
Company or its  stockholders  when the director was aware or should  have been
aware of a risk of  serious  injury to the  Company or its stockholders,  for
acts or omissions  that  constitute  an unexcused  pattern of inattention  that
amounts to an abdication of the director's duty to the Company or its
stockholders,  for  improper  transactions  between the director and the Company
and for improper  distributions  to stockholders  and loans to directors and
officers. These provisions do not affect a director's responsibilities under any
other  laws,  such as the  federal  securities  laws or  state  or  federal
environmental laws.

         The  Company's  Amended  and  Restated  Bylaws  require  the Company to
indemnify  its  directors  and  officers  against  expenses,  judgments,  fines,
settlements  and other  amounts  actually  and  reasonably  incurred  (including
expenses of a derivative  action) in  connection  with any  proceeding,  whether
actual or threatened,  to which any such person may be made a party by reason of
the fact that such  person is or was a director or officer of the Company or any
of its affiliated enterprises, provided such person acted in good faith and in a
manner  such  person  reasonably  believed  to be in or not  opposed to the best
interest of the Company and,  with respect to any  criminal  proceeding,  had no
reasonable  cause to believe  his or her  conduct was  unlawful.  The  Company's
Amended and Restated Bylaws also set forth certain procedures that will apply in
the event of a claim for indemnification thereunder.

Item 7.  Exemption from Registration Claimed

         Not applicable.

Item 8.           Exhibits

                  Exhibit
                  Number                             Description

                 5.1              Opinion of counsel regarding legality of
                                  securities being registered.
                23.1              Consent of certified public accountants.
                23.2              Consent of counsel (included in opinion filed
                                  as Exhibit 5.1).
                24.1              Power of Attorney (see page 4).

                                       2


<PAGE>

Item 9.  Undertakings

         (a) The undersigned registrant hereby undertakes:

                  (1) To file,  during any  period in which  offers or sales are
being made, a post-effective amendment to this registration statement to include
any material information with respect to the plan of distribution not previously
disclosed  in  the  registration  statement  or  any  material  change  to  such
information in the registration statement.

                  (2) That, for the purpose of determining  any liability  under
the Securities Act of 1933, each such  post-effective  amendment shall be deemed
to be a new registration  statement  relating to the securities offered therein,
and the  offering  of such  securities  at that  time  shall be deemed to be the
initial bona fide offering thereof.

                  (3) To remove from  registration by means of a  post-effective
amendment  any of the  securities  being  registered  which remain unsold at the
termination of the offering.

         (b) The undersigned  registrant hereby undertakes that, for purposes of
determining  any liability  under the Securities Act of 1933, each filing of the
registrant's  annual report pursuant to Section 13(a) or 15(d) of the Securities
Exchange Act of 1934 (and, where applicable,  each filing of an employee benefit
plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of
1934) that is incorporated by reference in the  registration  statement shall be
deemed to be a new  registration  statement  relating to the securities  offered
therein,  and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.

         (c)  Insofar  as  indemnification  for  liabilities  arising  under the
Securities Act of 1933 may be permitted to directors,  officers and  controlling
persons of the registrant  pursuant to the foregoing  provisions,  or otherwise,
the  registrant  has been  advised  that in the  opinion of the  Securities  and
Exchange  Commission such  indemnification is against public policy as expressed
in the Act and is,  therefore,  unenforceable.  In the  event  that a claim  for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
registrant  of expenses  incurred or paid by a director  officer or  controlling
person of the  registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]


                                       3


<PAGE>

                                   SIGNATURES


         Pursuant to the requirements of the Securities Act of 1933, the Company
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in  Research  Triangle  Park,  North  Carolina,  on the 27th day of
September 1996.


                                         INTERCARDIA, INC.


                                         By: /s/ CLAYTON I. DUNCAN
                                            -------------------------------
                                            Clayton I. Duncan
                                            President and
                                            Chief Executive Officer


                               POWER OF ATTORNEY

         Each person  whose  signature  appears  below in so signing also makes,
constitutes and appoints  CLAYTON I. DUNCAN and RICHARD W. REICHOW,  and each of
them acting alone, his or her true and lawful attorneys-in-fact, with full power
of substitution,  for him or her in any and all capacities, to execute and cause
to be filed with the Securities  and Exchange  Commission any and all amendments
and post-effective  amendments to this Form S-8, with exhibits thereto and other
documents in  connection  therewith,  and hereby  ratifies and confirms all that
said  attorneys-in-fact or his, her or their substitute or substitutes may do or
cause to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, as amended,
this Form S-8 has been signed below by the following  persons in the  capacities
and on the date indicated.


Signature                           Title                           Date


/s/ CLAYTON I. DUNCAN
- ----------------------------    President, Chief Executive    September 26, 1996
Clayton I. Duncan               Officer and Director
                                (Principal Executive
                                Officer)


/s/ RICHARD W. REICHOW
- ----------------------------    Senior Vice President,        September 26, 1996
Richard W. Reichow              Chief Financial Officer,
                                and Treasurer
                                (Principal Financial and
                                Accounting Officer)


/s/ GLENN L. COOPER
- ----------------------------    Director                      September 25, 1996
Glenn L. Cooper, M.D.


/s/ ROGER W. BRIMBLECOMBE
- ----------------------------    Director                      September 27, 1996
Roger W. Brimblecombe

                                       4


<PAGE>

/s/ JOSEPH J. RUVANE, JR.
- ----------------------------    Director                      September 25, 1996
Joseph J. Ruvane, Jr.


/s/ DAVID B. SHARROCK
- ----------------------------    Director                      September 26, 1996
David B. Sharrock


                                       5


<PAGE>

                               INDEX TO EXHIBITS


Exhibit                                                         
Number                                                          

 5.1         Opinion of counsel regarding legality of
             securities being registered.

23.1         Consent of certified public accountants.

23.2         Consent of counsel (included in opinion filed
             as Exhibit 5.1).

24.1         Power of Attorney (see page 4).


EXHIBIT 5.1

                    WYRICK, ROBBINS, YATES & PONTON, L.L.P.
                                Attorneys at Law

                                   The Summit
                        4101 Lake Boone Trail, Suite 300
                       Raleigh, North Carolina 27607-7506



                              September 27, 1996



Intercardia, Inc.
3200 East Highway 54
Cape Fear Building, Suite 300
Research Triangle Park, North Carolina  27709


         Re:      Registration Statement on Form S-8


Ladies and Gentlemen:

         We have  examined  the  Registration  Statement  on Form  S-8  filed by
Intercardia,  Inc., a Delaware corporation (the "Company"),  with the Securities
and  Exchange  Commission  on  September  27,   1996  (the   "Registration
Statement"),  in connection  with the  registration  under the Securities Act of
1933, as amended,  of 1,600,000 shares of the Company's Common Stock,  $.001 par
value per share  (the  "Shares").  We  understand  that the Shares are to issued
pursuant  to the  Company's  1994  Stock  Option  Plan and 1995  Employee  Stock
Purchase  Plan.  In our  examination,  we have  assumed the  genuineness  of all
signatures,  the authenticity of all documents  submitted to us as originals and
the  conformity  with the  original of all  documents  submitted to us as copies
thereof.

         As your legal counsel,  we have examined the proceedings taken, and are
familiar with the  proceedings  proposed to be taken,  by you in connection with
the sale and issuance of the Shares.

         It is our opinion that, upon completion of the proceedings  being taken
or contemplated by us, as your counsel, to be taken prior to the issuance of the
Shares,   including  the  proceedings  being  taken  in  order  to  permit  such
transaction to be carried out in accordance  with  applicable  state  securities
laws,  the Shares  when  issued in the manner  referred  to in the  Registration
Statement  and in  accordance  with  the  resolutions  adopted  by the  Board of
Directors of the  Company,  will be legally and validly  issued,  fully paid and
nonassessable.

         We consent to the use of this opinion as an exhibit to the Registration
Statement and further  consent to the use of our name wherever  appearing in the
Registration  Statement,  including the Prospectus  constituting a part thereof,
and any amendments thereto.

                                         Very truly yours,

                                         WYRICK, ROBBINS, YATES & PONTON, L.L.P.



                       CONSENT OF INDEPENDENT ACCOUNTANTS


We consent to the incorporation by reference in this  registration  statement of
Intercardia,  Inc. on Form S-8 (File No.___________) of our report dated October
19, 1995, on our audits of the financial  statements of Intercardia,  Inc. as of
September  30, 1995 and 1994 and for the year ended  September  30, 1995 and the
period from  inception  (March 15, 1994) to September 30, 1994,  which report is
included in the Company's Registration Statement on Form S-1 (File No. 33-80219)
and incorporated by reference in this registration statement on Form S-8.

COOPERS & LYBRAND L.L.P.
Raleigh, North Carolina
September 26, 1996



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