INTERCARDIA INC
8-K, 1997-11-07
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549


                                    FORM 8-K

                 Current Report Pursuant to Section 13 or 15(d)
                     of the Securities Exchange Act of 1934


                               NOVEMBER 5, 1997
                Date of Report (Date of earliest event reported)


                             INTERCARDIA, INC.
             (Exact name of registrant as specified in its charter)

                                 DELAWARE
         (STATE OR OTHER JURISDICTION OF INCORPORATION OR ORGANIZATION)


         0-27410                                    56-1924222
   (COMMISSION FILE NO.)               (I.R.S. EMPLOYER IDENTIFICATION NO.)


                             3200 EAST HIGHWAY 54,
                         CAPE FEAR BUILDING, SUITE 300
                                P. O. BOX 14287
                  RESEARCH TRIANGLE PARK, NORTH CAROLINA 27709
          (ADDRESS OF PRINCIPAL EXECUTIVE OFFICES, INCLUDING ZIP CODE)

                                 (919) 558-8688
              (REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE)


<PAGE>


Item 5.  Other Events.


         On November 5, 1997, the Registrant issued a press release stating as
follows:

                      "(Intercardia logo) Intercardia
Contact:                                  P.O. Box 14287
Intercardia:                              3200 East Highway 54
W. Bennett Love                           Cape Fear Building, Suite 300
919-558-1907                              Research Triangle Park, NC 27709-4287

Interneuron:                              919/558-8688
William B. Boni                           919/558-8686 fax
617-402-3410

For Immediate Release:

                  Intercardia to Acquire Transcell Technologies

Research Triangle Park, N.C., and Lexington, MA November 5, 1997 -- Intercardia,
Inc.  (Nasdaq:ITRC) and Interneuron  Pharmaceuticals,  Inc.  (Nasdaq:IPIC) today
announced  the  signing of a letter of intent for the  proposed  acquisition  by
Intercardia  of Transcell  Technologies,  Inc. and related  technology  owned by
Interneuron in exchange for Intercardia  common stock with an aggregate  current
market value of approximately $15 million.  In addition,  Intercardia will issue
Intercardia stock options to Transcell  employees and consultants with a current
market value of approximately $3-4 million.  The transaction is subject to final
due diligence and approval by Transcell's and Intercardia's  stockholders.  Both
Intercardia  and  Transcell  Technologies  are  majority-owned  subsidiaries  of
Interneuron.

Under the terms of the letter of intent,  owners of Transcell stock will receive
Intercardia  common stock in three installments with an aggregate current market
value  of  approximately  $12  million.  The  first  installment,   representing
approximately $6 million at Intercardia's current stock price, will be made upon
closing the  transaction,  currently  estimated  to occur in the first  calendar
quarter of 1998.  The number of  Intercardia  shares to be received by Transcell
stockholders at closing will be determined by  Intercardia's  stock price during
the week prior to closing.  The minimum  Intercardia  stock price to be used for
determining  the number of shares received for the initial  installment  will be
$19 per  share and the  maximum  will be $25 per  share.  The  second  and third
installments will each consist of approximately $3 million of Intercardia common
stock,  as valued at each  date,  and will be issued 15 and 21 months  after the
initial closing.

In exchange for certain license and technology rights owned by Interneuron,  and
for  Interneuron's   continuing   guarantee  of  certain  of  Transcell's  lease
obligations,  Intercardia  will issue to  Interneuron  $3 million of Intercardia
common stock (subject to the price range described above) at the initial closing
and will pay  Interneuron  a


<PAGE>


royalty  on certain  products  that may  result  from a  research  collaboration
originally entered into among Transcell, Interneuron and Merck.

At  closing,  Intercardia  and  Interneuron  will incur  charges  to  operations
currently  estimated  to be  approximately  $6-8  million  as a  result  of  the
transaction and will incur  additional  future charges relating to certain stock
options issued pursuant to the transaction.

Transcell's  mission is to discover and develop drugs based on  breakthroughs in
synthetic  carbohydrate  chemistry  primarily  made at Princeton  University  by
founding  scientist  Prof.  Daniel  Kahne.  This  platform   technology  enables
carbohydrate-based  combinatorial  libraries  of  compounds to be generated on a
solid support for uses in drug discovery.  Transcell's  platform  technology for
the generation of  carbohydrate-based  libraries includes solid phase chemistry,
robotics  systems  for  library  generation,  informatic  technologies  for data
storage and analysis and analytical  technologies  for solid phase chemistry and
library analysis.

In July 1997,  Transcell and  Interneuron  announced an agreement  with Merck to
discover and commercialize  novel antibacterial  agents.  Transcell will utilize
its combinatorial  technologies to prepare libraries of carbohydrate  derivative
compounds of two distinct structural classes. Additionally,  Merck has an option
to  extend  the  field  of  the   collaboration   and  license  to  include  all
antibacterial  pharmaceutical products. Merck made $2.5 million of payments upon
closing the agreement. Under the agreement, Transcell will also receive research
support for a minimum of two years.

For the nine months  period ended June 30, 1997,  Transcell had an unaudited net
loss of  approximately  $5 million.  Transcell has 32 employees,  all located at
Transcell's facilities outside Princeton, New Jersey.

"Intercardia is excited about the Transcell acquisition. We have been working to
establish   a   pipeline   of  drugs  to  follow   Bextra(TM)(bucindolol   HCl),
Intercardia's  vasodilating  beta-blocker  currently  under study in the pivotal
Phase III BEST Study for congestive  heart  failure,"  stated Clayton I. Duncan,
President  and CEO of  Intercardia.  "As Vice Chairman of  Transcell's  Board of
Directors,  I was directly involved in various corporate partnering  discussions
between Transcell and third parties and have gained a great appreciation for the
value of their carbohydrate combinatorial chemistry program."

"The acquisition of Transcell by Intercardia embodies Interneuron's strategy for
technological  synergy and growth among its subsidiaries," said Glenn L. Cooper,
M.D., President and CEO of Interneuron.  "Combinatorial  chemistry has become an
integral   component  of  modern  drug   discovery,   and  the   application  of
Intercardia's drug development and partnering  expertise will maximize the value
of Transcell's leading edge carbohydrate-based combinatorial chemistry."

<PAGE>


"An  additional  benefit  of  this  acquisition  is  the  preservation  of  both
Interneuron's  majority  ownership  position in  Intercardia  and its  continued
interest in Transcell," said Dr. Cooper.

Intercardia, a majority-owned subsidiary of Interneuron  Pharmaceuticals,  Inc.,
focuses on  cardiovascular  disease  and drug  discovery  and  development.  The
Company's  strategy  is to develop  and add value to  in-licensed  products  and
sponsored  research  programs  and to enter into  collaborations  and  licensing
agreements with corporate partners for final product development,  manufacturing
and  marketing.  Intercardia's  most advanced  product is  Bextra(TM)(bucindolol
HCl),  a drug  currently  in Phase III  clinical  trials  for the  treatment  of
congestive heart failure.

Interneuron  Pharmaceuticals is a diversified  biopharmaceutical company engaged
in the development and  commercialization of a portfolio of products and product
candidates primarily for neurological and behavioral  disorders.  Interneuron is
also developing products and technologies, generally outside the central nervous
system field, through two subsidiaries in addition to Intercardia and Transcell;
Progenitor,  Inc.  focused on  developmental  genomics,  and  InterNutria,  Inc.
focused on dietary supplement products.

Except for the  descriptions of historical  facts contained  herein,  this press
release contains forward-looking statements that involve risks and uncertainties
as detailed from time from time in Interneuron's and Intercardia's filings under
the Securities Act of 1933 and the Securities Exchange Act of 1934, including in
particular risks relating to the uncertainties  relating to clinical trials, and
other risks such as safety and regulatory risks, product liability,  litigation,
contractual  obligations,  the early  stage of  products  under  development  by
Transcell and funding requirements for such product development and with respect
to Interneuron,  litigation  risks and other risks relating to the withdrawal of
Redux."

<PAGE>



                                   SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this Report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                INTERCARDIA, INC.


                         By:  /s/ Richard W. Reichow
                              Richard W. Reichow
                              Senior Vice President and Chief Financial Officer




Date: November 6, 1997




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