DOMAIN PARTNERS III L PET AL
SC 13G, 1997-02-12
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CUSIP No. 0002078541                                      Page 1 of 9 Pages


                    SECURITIES AND EXCHANGE COMMISSION
                          Washington, D.C.  20549


                         ________________________


                               SCHEDULE 13G

          Information Statement Pursuant to Rules 13d-1 and 13d-2
                 Under the Securities Exchange Act of 1934

                             (Amendment No. )


                      Connective Therapeutics, Inc.                   
    __________________________________________________________________
                             (Name of Issuer)



                              Common Stock                            
     _________________________________________________________________
                      (Title of Class of Securities)



                               0002078541                             
     ________________________________________________________________
                              (CUSIP Number)













                                                 





                                     
<PAGE>
CUSIP No. 0002078541                                      Page 2 of 9 Pages
__________________________________________________________       
1)   Name of Reporting Person                 Domain Partners 
     S.S. or I.R.S. Identification            III, L.P.
     No. of Above Person
_________________________________________________________________
2)   Check the Appropriate Box                  (a) [ X ]
     if a Member of a Group                     (b) [   ]        
_________________________________________________________________
3)   SEC Use Only
_________________________________________________________________
4)   Citizenship or Place                     Delaware
     of Organization                                             
_________________________________________________________________
Number of                5)   Sole Voting    592,450 shares of  Shares
Beneficially             Power          Common Stock       
Owned by Each                                                   
Reporting Person                                                 
                         ________________________________________
                         6)   Shared Voting 
                              Power                -0-           
                         ________________________________________
                         7)   Sole Disposi-  592,450 shares of 
                              tive Power     Common Stock        
                         ________________________________________
                         8)   Shared Dis-
                              positive Power       -0-           
                         ________________________________________

9)   Aggregate Amount Beneficially           592,450 shares of 
     Owned by Each Reporting person          Common Stock        
_________________________________________________________________
10)  Check if the Aggregate
     Amount in Row (9)
     Excludes Certain Shares                                     
_________________________________________________________________
11)  Percent of Class
     Represented by                           6.5%
     Amount in Row (9)                                           
_________________________________________________________________
12)  Type of Reporting 
     Person                                  PN
<PAGE>
CUSIP No. 0002078541                                      Page 3 of 9 Pages
__________________________________________________________       
1)   Name of Reporting Person                 DP III Associates,
     S.S. or I.R.S. Identification            L.P.
     No. of Above Person                      
_________________________________________________________________
2)   Check the Appropriate Box                  (a) [ X ]
     if a Member of a Group                     (b) [   ]
_________________________________________________________________
3)   SEC Use Only
_________________________________________________________________
4)   Citizenship or Place                     Delaware
     of Organization
_________________________________________________________________
Number of                5)   Sole Voting    20,734 shares of
Shares Beneficially           Power          Common Stock
Owned by Each
Reporting Person
                         ________________________________________
                         6)   Shared Voting 
                              Power               -0-
                         ________________________________________
                         7)   Sole Disposi-  20,734 shares of
                              tive Power     Common Stock
                         ________________________________________
                         8)   Shared Dis-
                              positive Power       -0-
                         ________________________________________

9)   Aggregate Amount Beneficially           20,734 shares of 
     Owned by Each Reporting person          Common Stock
_________________________________________________________________
10)  Check if the Aggregate
     Amount in Row (9)
     Excludes Certain Shares
_________________________________________________________________
11)  Percent of Class
     Represented by                          0.2%
     Amount in Row (9)
_________________________________________________________________
12)  Type of Reporting 
     Person                                  PN
<PAGE>
CUSIP No. 0002078541                                      Page 4 of 9 Pages
__________________________________________________________       
1)   Name of Reporting Person                 Domain Associates  
     S.S. or I.R.S. Identification                
     No. of Above Person                      
_________________________________________________________________
2)   Check the Appropriate Box                  (a) [ X ]
     if a Member of a Group                     (b) [   ]
_________________________________________________________________
3)   SEC Use Only
_________________________________________________________________
4)   Citizenship or Place                     New Jersey
     of Organization
_________________________________________________________________
Number of                5)   Sole Voting     4,215 shares of Shares
Beneficially             Power           Common Stock 
Owned by Each
Reporting Person
                         ________________________________________
                         6)   Shared Voting 
                              Power               -0-
                         ________________________________________
                         7)   Sole Disposi-   4,215 shares of
                              tive Power      Common Stock
                         ________________________________________
                         8)   Shared Dis-
                              positive Power       -0-
                         ________________________________________

9)   Aggregate Amount Beneficially            4,215 shares of
     Owned by Each Reporting person           Common Stock
_________________________________________________________________
10)  Check if the Aggregate
     Amount in Row (9)
     Excludes Certain Shares
_________________________________________________________________
11)  Percent of Class
     Represented by                             0.1%  
     Amount in Row (9)
_________________________________________________________________
12)  Type of Reporting 
     Person                                  PN
<PAGE>
CUSIP No. 0002078541                                      Page 5 of 9 Pages
                               Schedule 13G
                               ____________

Item 1(a) -    Name of Issuer:  Connective Therapeutics, Inc.

Item 1(b) -    Address of Issuer's Principal Executive Offices:

               3400 West Bayshore Road
               Palo Alto, CA  94303

Item 2(a) -    Name of Person Filing:

               This statement is being filed by Domain Partners III, L.P.,
               a Delaware limited partnership ("Domain III"), DP III
               Associates, L.P., a Delaware limited partnership ("DP III
               A"), and Domain Associates, a New Jersey general partnership
               ("DA") (collectively, the "Reporting Persons").

Item 2(b) -    Address of Principal Business Office:

               One Palmer Square
               Princeton, NJ  08542

Item 2(c) -    Place of Organization:

               Domain III:  Delaware
               DP III A:  Delaware
               DA:  New Jersey

Item 2(d) -    Title of Class of Securities:

               Common Stock

Item 2(e) -    CUSIP Number:  0002078541

Item 3 -       Statements Filed Pursuant to Rules 13d-1(b) or
               13d-2(b):

               Not applicable.

Item 4 -       Ownership.

               (a)  Amount Beneficially Owned:

               Domain III:  592,450 shares of Common Stock
               DP III A:  20,734 shares of Common Stock
               DA:  4,215 shares of Common Stock
               
<PAGE>
CUSIP No. 0002078541                                      Page 6 of 9 Pages
               (b)  Percent of Class:

               Domain III: 6.5%
               DP III A: 0.2%
               DA: 0.1%
               
               (c)  Number of shares as to which such person has:

               (i)  sole power to vote or to direct the vote:  
               Domain III:  592,450 shares of Common Stock
               DP III A:  20,734 shares of Common Stock
               DA:  4,215 shares of Common Stock

               (ii) shared power to vote or to direct the vote:  -0-

               (iii) sole power to dispose or to direct the disposition of: 
               
               Domain III:  592,450 shares of Common Stock
               DP III A:  20,734 shares of Common Stock
               DA:  4,215 shares of Common Stock

               (iv) shared power to dispose or to direct the disposition
                    of:  -0-

Item 5 -       Ownership of Five Percent or Less of a Class:

               Not applicable.

Item 6 -       Ownership of More than Five Percent on Behalf of  
               Another Person:

               Not applicable.

Item 7 -       Identification and Classification of the
               Subsidiary Which Acquired the Security Being
               Reported on by the Parent Company:

               Not applicable.

Item 8 -       Identification and Classification of Members of
               the Group:

               See Exhibit 2.

Item 9 -       Notice of Dissolution of Group:  Not applicable.

Item 10 -      Certification:  Not applicable.
<PAGE>
CUSIP No. 0002078541                                      Page 7 of 9 Pages
Signature:

          After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

                              DOMAIN PARTNERS III, L.P.
                              By:  One Palmer Square Associates    III
                              L.P., General Partner

                              By /s/ Kathleen K. Schoemaker     
                                   General Partner     


                              DP III ASSOCIATES, L.P.
                              By:  One Palmer Square Associates    III
                              L.P., General Partner

                              By  /s/ Kathleen K. Schoemaker    
                                   General Partner     


                              DOMAIN ASSOCIATES       
                                                                            
                                                  
                              By    /s/ Kathleen K. Schoemaker  
                                   General Partner     


Date: January 31, 1997

<PAGE>
CUSIP No. 0002078541                                      Page 8 of 9 Pages
EXHIBIT 1
                               AGREEMENT OF
                        DOMAIN PARTNERS III, L.P.,
                          DP III ASSOCIATES, L.P.
                                    AND
                             DOMAIN ASSOCIATES
                         PURSUANT TO RULE 13d-1(f)
                         _________________________

          The undersigned hereby agree that the Information Statement on
Schedule 13G to which this Agreement is annexed as Exhibit 1 is filed on
behalf of each of them in accordance with the provisions of 13d-1(f) under
the Securities Exchange Act of 1934, as amended.

                              DOMAIN PARTNERS III, L.P.
                              By:  One Palmer Square Associates    III
                              L.P., General Partner

                              By  /s/ Kathleen K. Schoemaker    
                                   General Partner     


                              DP III ASSOCIATES, L.P.
                              By:  One Palmer Square Associates    III
                              L.P., General Partner

                              By  /s/ Kathleen K. Schoemaker    
                                   General Partner     


                              DOMAIN ASSOCIATES       
                                                                            
                                                  
                              By  /s/ Kathleen K. Schoemaker    
                                   General Partner     




Date: January 31, 1997

<PAGE>
CUSIP No. 0002078541                                      Page 9 of 9 Pages
EXHIBIT 2

                     Identification and Classification
                           of Members of the Group    
                     _________________________________

          Domain Partners III, L.P., DP III Associates, L.P. and Domain
Associates are filing this statement on Schedule 13G as a group.

          Domain Partners III, L.P. is a Delaware limited partnership.  Its
sole general partner is One Palmer Square Associates III, L.P., a Delaware
limited partnership.          

          DP III Associates, L.P. is a Delaware limited partnership.  Its
sole general partner is One Palmer Square Associates III, L.P., a Delaware
limited partnership.

          Domain Associates is a New Jersey general partnership.


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