DOMAIN PARTNERS III L PET AL
SC 13G/A, 1999-02-09
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CUSIP No. 0000519201                                           Page 1 of 5 Pages



                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                             ----------------------


                                  SCHEDULE 13G
                                 (Rule 13d-102)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILES PURSUANT
           TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)
                               (Final Amendment)1

                         Aurora Biosciences Corporation
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.001 par value
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   0000519201
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 1998
- --------------------------------------------------------------------------------
              Date of Event Which Requires Filing of this Statement

Check the appropriate box to designate the rule pursuant to which this Schedule
is Filed:

         [ ] Rule 13d-1(b)
         [ ] Rule 13d-1(c)
         [X] Rule 13d-1(d)



- --------
         1The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page. The information required on
the remainder of this cover page shall not be deemed to be "filed" for the
purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise
subject to the liabilities of that section of the Act but shall be subject to
all other provisions of the Act.


<PAGE>

CUSIP No. 0000519201                                           Page 2 of 5 Pages


- --------------------------------------------------------------------------------
1)   Name of Reporting Person                          Domain Partners
     I.R.S. Identification                             III, L.P.
     No. of Above Person
     (Entities Only)                                             
- --------------------------------------------------------------------------------
2)   Check the Appropriate Box                             (a) [ X ]
     if a Member of a Group                                (b) [   ]
- --------------------------------------------------------------------------------
3)   SEC Use Only
- --------------------------------------------------------------------------------
4)   Citizenship or Place                              Delaware
     of Organization
- --------------------------------------------------------------------------------
Number of                    5)   Sole Voting              -0-
Shares Beneficially               Power
Owned by Each
Reporting Person
                             ---------------------------------------------------
                             6)   Shared Voting
                                  Power                    -0-
                             ---------------------------------------------------
                             7)   Sole Disposi-            -0-
                                  tive Power
                             ---------------------------------------------------
                             8)   Shared Dis-
                                  positive Power           -0-
                             ---------------------------------------------------

9)   Aggregate Amount Beneficially                         -0-
     Owned by Each Reporting person
- --------------------------------------------------------------------------------
10)  Check if the Aggregate Amount in Row (9)
     Excludes Certain Shares
- --------------------------------------------------------------------------------
11)  Percent of Class
     Represented by                                        -0-
     Amount in Row (9)
- --------------------------------------------------------------------------------
12)  Type of Reporting
     Person                                            PN

<PAGE>

CUSIP No. 0000519201                                           Page 3 of 5 Pages


- --------------------------------------------------------------------------------
1)   Name of Reporting Person                          DP III Associates,
     I.R.S. Identification                             L.P.
     No. of Above Person
     (Entities Only)                                             
- --------------------------------------------------------------------------------
2)   Check the Appropriate Box                             (a) [ X ]
     if a Member of a Group                                (b) [   ]
- --------------------------------------------------------------------------------
3)   SEC Use Only
- --------------------------------------------------------------------------------
4)   Citizenship or Place                              Delaware
     of Organization
- --------------------------------------------------------------------------------
Number of                    5)   Sole Voting              -0-
Shares Beneficially               Power
Owned by Each
Reporting Person
                             ---------------------------------------------------
                             6)   Shared Voting
                                  Power                    -0-
                             ---------------------------------------------------
                             7)   Sole Disposi-            -0-
                                  tive Power
                             ---------------------------------------------------
                             8)   Shared Dis-
                                  positive Power           -0-
                             ---------------------------------------------------

9)   Aggregate Amount Beneficially                         -0-
     Owned by Each Reporting person
- --------------------------------------------------------------------------------
10)  Check if the Aggregate
     Amount in Row (9)
     Excludes Certain Shares
- --------------------------------------------------------------------------------
11)  Percent of Class
     Represented by                                        -0-
     Amount in Row (9)
- --------------------------------------------------------------------------------
12)  Type of Reporting
     Person                                            PN

<PAGE>

CUSIP No. 0000519201                                           Page 4 of 5 Pages

                         Final Amendment to Schedule 13G
                         -------------------------------

          Reference is hereby made to the statement on Schedule 13G originally
filed on February 6, 1998 (the "Schedule 13G"). Terms used in the Schedule 13G
are used herein as so defined.

          The following Items of the Schedule 13G are hereby amended and
restated to read in their entirety as follows:

Item 4 - Ownership.

         (a)  Amount Beneficially Owned:

         Domain III:  -0-
         DP III A:  -0-

         (b)  Percent of Class:

         Domain III: -0-
         DP III A: -0-

         (c)  Number of shares as to which such person has:

         (i)  sole power to vote or to direct the vote:
         Domain III:  -0-
         DP III A:  -0-

         (ii) shared power to vote or to direct the vote:  -0-

         (iii) sole power to dispose or to direct the disposition of:
         Domain III:  -0-
         DP III A:  -0-

         (iv) shared power to dispose or to direct the
         disposition of:  -0-

Item 5 - Ownership of Five Percent or Less of a Class:

         This statement is being filed to report the fact that as of the date
hereof the Reporting Persons have ceased to be the beneficial owners of more
than five percent of the Common Stock.

<PAGE>

CUSIP No. 0000519201                                           Page 5 of 5 Pages

Signature:

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


                                               DOMAIN PARTNERS III, L.P.
                                               By:  One Palmer Square Associates
                                               III L.P., General Partner

                                               By /s/ Kathleen K. Schoemaker
                                               ---------------------------------
                                                    General Partner


                                               DP III ASSOCIATES, L.P.
                                               By:  One Palmer Square Associates
                                               III L.P., General Partner

                                               By /s/ Kathleen K. Schoemaker
                                               ---------------------------------
                                                    General Partner

Date: February 2, 1999



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