VENROCK ASSOCIATES
SC 13G, 2000-02-14
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<PAGE>

                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                                 SCHEDULE 13G
                                (Rule 13d-102)

            INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
          TO RULES 13d-1(b) (c), AND (d) AND AMENDMENTS THERETO FILED
                           PURSUANT TO RULE 13d-2(b)


                              Symyx Technologies
- --------------------------------------------------------------------------------
                               (Name of Issuer)

                                 Common Stock
- --------------------------------------------------------------------------------
                        (Title of Class of Securities)

                                   87155S108
                        ------------------------------
                                (CUSIP Number)

                               November 17, 1999
- --------------------------------------------------------------------------------
            (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
                                   is filed:

               [_]  Rule 13d-1(b)

               [_]  Rule 13d-(c)

               [X]  Rule 13d-1(d)

                    *The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information which
would alter the disclosures provided in a prior cover page.

                    The information required in the remainder of this cover page
shall not be deemed to be "filed" for the purpose of Section 18 of the
Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities
of that section of the Act but shall be subject to all other provisions of the
Act (however, see the Notes).
<PAGE>

- -----------------------------                         --------------------------
  CUSIP NO.  87155S108                13G                 Page 2 of 16 Pages
             ---------
- -----------------------------                         --------------------------

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON

      Venrock Associates
      I.R.S.#13-6300995
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [X]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      New York, U.S.A.

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          1,030,942
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          1,030,942
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      1,030,942
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      3.71%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      PN

- ------------------------------------------------------------------------------

                      *SEE INSTUCTION BEFORE FILLING OUT!

                              Page 2 of 16 pages
<PAGE>

- -----------------------------                         --------------------------
  CUSIP NO.  87155S108                13G                 Page 3 of 16 Pages
             ---------
- -----------------------------                         --------------------------

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON

      Venrock Associates II, L.P.
      I.R.S.#13-3844754
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [X]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      New York, U.S.A.

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          665,041
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          665,041
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      665,041
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      2.40%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      PN

- ------------------------------------------------------------------------------

                      *SEE INSTUCTION BEFORE FILLING OUT!

                              Page 3 of 16 pages
<PAGE>

- -----------------------------                         --------------------------
  CUSIP NO.  87155S108                13G                 Page 4 of 16 Pages
             ---------
- -----------------------------                         --------------------------

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON

      Anthony B. Evnin
      ###-##-####
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [X]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      U.S.A.

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          1,695,983
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          1,695,983
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      1,695,983
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      6.11%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      IN

- ------------------------------------------------------------------------------

                      *SEE INSTUCTION BEFORE FILLING OUT!

                              Page 4 of 16 pages
<PAGE>

- -----------------------------                         --------------------------
  CUSIP NO.  87155S108                13G                 Page 5 of 16 Pages
             ---------
- -----------------------------                         --------------------------

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON

      David R. Hathaway
      ###-##-####
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [X]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      U.S.A.

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          1,695,983
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          1,695,983
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      1,695,983
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      6.11%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      IN

- ------------------------------------------------------------------------------

                      *SEE INSTUCTION BEFORE FILLING OUT!

                              Page 5 of 16 pages
<PAGE>

- -----------------------------                         --------------------------
  CUSIP NO.  87155S108                13G                 Page 6 of 16 Pages
             ---------
- -----------------------------                         --------------------------

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON

      Patrick F. Latterell
      ###-##-####
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [X]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      U.S.A.

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          1,695,983
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          1,695,983
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      1,695,983
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      6.11%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      IN

- ------------------------------------------------------------------------------

                      *SEE INSTUCTION BEFORE FILLING OUT!

                              Page 6 of 16 pages
<PAGE>

- -----------------------------                         --------------------------
  CUSIP NO.  87155S108                13G                 Page 7 of 16 Pages
             ---------
- -----------------------------                         --------------------------

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON

      Ted H. McCourtney
      ###-##-####
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [X]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      U.S.A.

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          1,695,983
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          1,695,983
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      1,695,983
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      6.11%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      IN

- ------------------------------------------------------------------------------

                      *SEE INSTUCTION BEFORE FILLING OUT!

                              Page 7 of 16 pages
<PAGE>

- -----------------------------                         --------------------------
  CUSIP NO.  87155S108                13G                 Page 8 of 16 Pages
             ---------
- -----------------------------                         --------------------------

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON

      Ray A. Rothrock
      ###-##-####
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [X]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      U.S.A.

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          1,695,983
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          1,695,983
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      1,695,983
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      6.11%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      IN

- ------------------------------------------------------------------------------

                      *SEE INSTUCTION BEFORE FILLING OUT!

                              Page 8 of 16 pages
<PAGE>

- -----------------------------                         --------------------------
  CUSIP NO.  87155S108                13G                 Page 9 of 16 Pages
             ---------
- -----------------------------                         --------------------------

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON

      Kimberley A. Rummelsburg
      ###-##-####
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [X]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      U.S.A.

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          1,695,983
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          1,695,983
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      1,695,983
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      6.11%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      IN

- ------------------------------------------------------------------------------

                      *SEE INSTUCTION BEFORE FILLING OUT!

                              Page 9 of 16 pages
<PAGE>

- -----------------------------                         --------------------------
  CUSIP NO.  87155S108                13G                 Page 10 of 16 Pages
             ---------
- -----------------------------                         --------------------------

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSON
 1    S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON

      Anthony Sun
      ###-##-####
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [X]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      U.S.A.

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            0

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          1,695,983
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             0

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          1,695,983
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      1,695,983
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11
      6.11%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12
      IN

- ------------------------------------------------------------------------------

                      *SEE INSTUCTION BEFORE FILLING OUT!

                              Page 10 of 16 pages
<PAGE>

          Introductory Note:  This Statement on Schedule 13G is filed on behalf
of Venrock Associates, a limited partnership organized under the laws of the
State of New York, Venrock Associates II, L.P., a limited partnership organized
under the laws of the State of New York, Anthony B. Evnin, David R. Hathaway,
Patrick F. Latterell, Ted H. McCourtney, Ray A. Rothrock, Kimberley A.
Rummelsburg and Anthony Sun in respect of shares of Common Stock of Symyx
Technologies.

Item 1(a)      Name of Issuer
- -----------------------------

               Symyx Technologies

Item 1(b)      Address of Issuer's Principal Executive Offices
- --------------------------------------------------------------

               3100 Central Expressway
               Santa Clara, CA  95051

Item 2(a)      Name of Person Filing
- ------------------------------------

               Venrock Associates ("Venrock")
               Venrock Associates II, L.P. ("Venrock II")



               Anthony B. Evnin
               David R. Hathaway
               Patrick F. Latterell
               Ted H. McCourtney
               Ray A. Rothrock
               Kimberley A. Rummelsburg
               Anthony Sun

Item 2(b)      Address of Principal Business Office or, if none, Residence
- --------------------------------------------------------------------------

               New York Office:                       Menlo Park Office:
               30 Rockefeller Plaza                   2494 Sand Hill Road
               Room 5508                              Suite 200
               New York, NY 10112                     Menlo Park, CA 94025

Item 2(c)      Citizenship
- --------------------------

               Venrock and Venrock II are limited partnerships organized in the
               State of New York. Anthony B. Evnin, David R. Hathaway, Patrick
               F. Latterell, Ted H. McCourtney, Ray A. Rothrock, Kimberley A.
               Rummelsburg and Anthony Sun are General Partners of Venrock and
               Venrock II and all are citizens of the United States of America.

Item 2(d)      Title of Class of Securities
- -------------------------------------------

               Common Stock

Item 2(e)      CUSIP Number
- --------------------------

               87155S108

Item 3         Not applicable.
- ------


Item 4         Ownership
- ------------------------

               (a) and (b)

                              Page 11 of 16 pages
<PAGE>

               Venrock owns 1,030,942 shares or 3.71% of the outstanding shares
               of common stock. Venrock II owns 665,041 shares or 2.40% of the
               outstanding shares of common stock.

               Each of Anthony B. Evnin, David R. Hathaway, Patrick F.
               Latterell, Ted H. McCourtney, Ray A. Rothrock, Kimberley A.
               Rummelsburg and Anthony Sun beneficially owns 1,695,983 shares or
               6.11% of the outstanding shares of common stock.

               (c)

               Each of Anthony B. Evnin, David R. Hathaway, Patrick F.
               Latterell, Ted H. McCourtney, Ray A. Rothrock, Kimberley A.
               Rummelsburg and Anthony Sun has sole voting and dispositive power
               over no shares of common stock and shared voting and dispositive
               power over 1,695,983 shares of common stock.

Item 5         Ownership of Five Percent or Less of a Class
- -----------------------------------------------------------

               If this statement is being filed to report the fact that as of
               the date hereof the reporting person has ceased to be the
               beneficial owner of more than five percent of the class of
               securities, check the following [ ].

Item 6         Ownership of More than Five Percent of Behalf of Another Person
- ------------------------------------------------------------------------------

               No person, other than the General Partners of Venrock and Venrock
               II, has the right to receive or the power to direct the receipt
               of dividends from, or the proceeds from the sale of, the shares
               of common stock owned by Venrock and Venrock II.

Item 7         Identification and Classification of the Subsidiary which
- ------------------------------------------------------------------------
               Acquired the Security Being Reported on by the Parent Holding
               -------------------------------------------------------------
               Company
               -------

               Not applicable.

Item 8         Identification and Classification of Members of the Group
- ------------------------------------------------------------------------

               This schedule is being filed pursuant to Rule 13d-1(d).  The
               identities of the seven General Partners of Venrock and Venrock
               II are stated in Item 2.

Item 9         Notice of Dissolution of Group
- ---------------------------------------------

               Not applicable.

Item 10        Certification
- ----------------------------

               Not applicable.

                              Page 12 of 16 pages
<PAGE>

                                   SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this Statement is true, complete and
correct.

February 14, 2000                      VENROCK ASSOCIATES

                                            By:  /s/ Ted H. McCourtney
                                               ----------------------------
                                               Ted H. McCourtney
                                               General Partner


February 14, 2000                      VENROCK ASSOCIATES II, L.P.


                                            By:  /s/ Ted H. McCourtney
                                               ----------------------------
                                               Ted H. McCourtney
                                               General Partner


February 14, 2000                      GENERAL PARTNERS


                                            /s/  Anthony B. Evnin
                                            -------------------------------
                                            Anthony B. Evnin

                                            /s/  David R. Hathaway
                                            -------------------------------
                                            David R. Hathaway

                                            /s/  Patrick F. Latterell
                                            -------------------------------
                                            Patrick F. Latterell

                                            /s/  Ted H. McCourtney
                                            -------------------------------
                                            Ted H. McCourtney

                                            /s/  Ray A. Rothrock
                                            -------------------------------
                                            Ray A. Rothrock

                                            /s/  Kimberley A. Rummelsburg
                                            -------------------------------
                                            Kimberley A. Rummelsburg

                                            /s/  Anthony Sun
                                            -------------------------------
                                            Anthony Sun

                              Page 13 of 16 pages
<PAGE>

                                 Exhibit Index
                                 -------------


Exhibit No.                                                          Page No.
- -----------                                                          --------
   24.1        Power of Attorney dated as of February 14, 2000          15
               granted by the General Partners in favor of Ted
               McCourtney

   99.1        Agreement pursuant to 13d-1(k)(1) among Venrock          16
               Associates, Venrock Associates II, L.P. and the
               General Partners thereof

                              Page 14 of 16 pages

<PAGE>

                                                                    Exhibit 24.1
                                                                    ------------

                               POWER OF ATTORNEY

          KNOWN ALL MEN BY THESE PRESENTS that each person whose signature
appears below constitutes and appoints Ted H. McCourtney his or her true and
lawful attorney-in-fact and agent, acting alone, with full power of substitution
and resubstitution, for him or her and in his or her name, place and stead, in
any and all capacities, to sign the Schedule 13G, and all amendments thereto,
with all exhibits thereto, and all documents in connection therewith, with
respect to the beneficial ownership by the undersigned of the equity securities
of Symyx Technologies, and to file the same, with the Securities and Exchange
Commission and any other person, granting unto the attorney-in-fact and agent
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in and about the premises, as fully to all
intents and purposes as he or she might or could do in person, and hereby
ratifies and confirms all that said attorney-in-fact and agent or his substitute
or substitutes, may lawfully do or cause to be done.

                                       February 14, 2000


                                       /s/  Anthony B. Evnin
                                       ------------------------------
                                       Anthony B. Evnin

                                       /s/  David R. Hathaway
                                       ------------------------------
                                       David R. Hathaway

                                       /s/  Patrick F. Latterell
                                       ------------------------------
                                       Patrick F. Latterell

                                       /s/  Ted H. McCourtney
                                       ------------------------------
                                       Ted H. McCourtney

                                       /s/  Ray A. Rothrock
                                       ------------------------------
                                       Ray A. Rothrock

                                       /s/  Kimberley A. Rummelsburg
                                       ------------------------------
                                       Kimberley A. Rummelsburg

                                       /s/  Anthony Sun
                                       ------------------------------
                                       Anthony Sun

                              Page 15 of 16 pages

<PAGE>

                                                                    Exhibit 99.1
                                                                    ------------

                                   AGREEMENT

          Pursuant to Rule 13d-1(k)(1) promulgated pursuant to the Securities
Exchange Act of 1934, as amended, the undersigned agree that the attached
Schedule 13G is being filed on behalf of each of the undersigned.

February 14, 2000                 VENROCK ASSOCIATES


                                       By:  /s/ Ted H. McCourtney
                                            ------------------------------
                                            Ted H. McCourtney
                                            General Partner


February 14, 2000                 VENROCK ASSOCIATES II, L.P.


                                       By:  /s/ Ted H. McCourtney
                                            ------------------------------
                                            Ted H. McCourtney
                                            General Partner


February 14, 2000                 GENERAL PARTNERS


                                       /s/  Anthony B. Evnin
                                       -----------------------------------
                                       Anthony B. Evnin

                                       /s/  David R. Hathaway
                                       -----------------------------------
                                       David R. Hathaway

                                       /s/  Patrick F. Latterell
                                       -----------------------------------
                                       Patrick F. Latterell

                                       /s/  Ted H. McCourtney
                                       -----------------------------------
                                       Ted H. McCourtney

                                       /s/  Ray A. Rothrock
                                       -----------------------------------
                                       Ray A. Rothrock

                                       /s/  Kimberley A. Rummelsburg
                                       -----------------------------------
                                       Kimberley A. Rummelsburg

                                       /s/  Anthony Sun
                                       -----------------------------------
                                       Anthony Sun

                              Page 16 of 16 pages


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