EXELIXIS INC
SC 13G, 2000-12-14
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  ------------

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                                (Amendment No. )

                                 Exelixis, Inc.
                         ------------------------------
                                (Name of issuer)

                    Common Stock, par value $0.001 per share
                    ----------------------------------------
                         (Title of class of securities)

                                    30161Q104
            -------------------------------------------------------
                                 (CUSIP number)

                                December 6, 2000
             -------------------------------------------------------
             (Date of Event which requires filing of this Statement)

     Check the appropriate box to designate the rule pursuant to which this
                               schedule is filed:

                               | | Rule 13d-1 (b)
                               |X| Rule 13d-1 (c)
                               | | Rule 13d-1 (d)

<PAGE>


-------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Bank A.G.
-------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) |_|

                                                                       (b) |_|
-------- -----------------------------------------------------------------------
3        SEC USE ONLY

-------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
--------------------------------------------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ------ --------------------------------------------
BENEFICIALLY                        SHARED VOTING POWER
OWNED BY                     6      2,434,700
                             ------ --------------------------------------------
EACH                                SOLE DISPOSITIVE POWER
REPORTING                    7      0
                             ------ --------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      2,434,700
-------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,434,700*
-------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                  |_|
-------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         5.4%**
-------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC, BK, CO
-------- -----------------------------------------------------------------------

*  Included in this figure are the securities reported by Deutsche Fonds Holding
   GmbH and DWS Investment GmbH on the following cover pages.

** Included in this  percentage  is the  percentage  of  securities  reported by
   Deutsche  Fonds  Holding GmbH and DWS Investment GmbH on the following  cover
   pages.

<PAGE>

-------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Fonds Holding GmbH
-------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) |_|
                                                                       (b) |_|
-------- -----------------------------------------------------------------------
3        SEC USE ONLY

-------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
---------------------------- ------ --------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ------ --------------------------------------------
BENEFICIALLY                        SHARED VOTING POWER
OWNED BY                     6      2,434,700
                             ------ --------------------------------------------
EACH                                SOLE DISPOSITIVE POWER
REPORTING                    7      0
                             ------ --------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      2,434,700
-------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,434,700
-------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                    |_|
-------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         5.4%
-------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC
-------- -----------------------------------------------------------------------

*  Included in this figure are the securities reported by DWS Investment GmbH on
   the following cover page.

** Included in this  percentage is the percentage of securities  reported by DWS
   Investment GmbH on the following cover page.

<PAGE>

-------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         DWS Investment GmbH
-------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) |_|
                                                                       (b) |_|
-------- -----------------------------------------------------------------------
3        SEC USE ONLY

-------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
---------------------------- ------ --------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ------ --------------------------------------------
BENEFICIALLY                        SHARED VOTING POWER
OWNED BY                     6      2,240,700
                             ------ --------------------------------------------
EACH                                SOLE DISPOSITIVE POWER
REPORTING                    7      0
                             ------ --------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      2,240,700
-------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,240,700
-------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                    |_|
-------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         5.0%
-------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         CO
-------- -----------------------------------------------------------------------

<PAGE>

Item 1(a).        Name of Issuer:

                  Exelixis, Inc. (the "Issuer")

Item 1(b).        Address of Issuer's Principal Executive Offices:

                  The address of the Issuer's principal executive offices is 170
Harbor Way, P.O. Box 511, South San Francisco, California 94083.

Item 2(a).        Name of Person Filing:

                  This  statement  is  filed  on  behalf  of  Deutsche  Bank  AG
("DBAG"),  Deutsche  Funds  Holding GmbH ("DWS Group") and DWS  Investment  GmbH
("DWS" and, together with DBAG and DWS Group, the "Reporting Persons").

Item 2(b).        Address of Principal Business Office or, if none, Residence:

                  The principal  place of business of DBAG is  Taunusanlage  12,
D-60325, Frankfurt am Main, Federal Republic of Germany.

                  The   principal   place   of   business   of  DWS   Group   is
Feldbergstrasse 22, 60323 Frankfurt, Federal Republic of Germany.

                  The  principal  place  of  business  of  DWS  is  Gruneburgweg
113-115, 60612 Frankfurt, Federal Republic of Germany.

Item 2(c).        Citizenship:

                  The  citizenship of the Reporting  Persons is set forth on the
applicable cover page.

Item 2(d).        Title of Class of Securities:

                  The title of the  securities  is  common  stock  (the  "Common
Stock").

Item 2(e).        CUSIP Number:

                  The  CUSIP  number  of the  Common  Stock is set forth on each
cover page.

Item 3.           If this statement is filed pursuant to Rules 13d-1(b), or
                  13d-2(b) or (c), check whether the person filing is a:

                 (a)    |_|  Broker or dealer registered under section 15 of the
                             Act;

                 (b)    |_|  Bank as defined in section 3(a)(6) of the Act;

                 (c)    |_|  Insurance Company as defined in section 3(a)(19) of
                             the Act;

                 (d)    |_|  Investment Company registered under section 8 of
                             the Investment Company Act of 1940;

                 (e)    |_|  An investment adviser in accordance with Rule
                             13d-1(b)(1)(ii)(E);

                 (f)    |_|  An employee benefit plan, or endowment fund in
                             accordance with Rule 13d-1 (b)(1)(ii)(F);

                 (g)    |_|  A parent holding company or control person in
                             accordance with Rule 13d-1 (b)(1)(ii)(G);

                 (h)    |_|  A savings association as defined in section 3(b)
                             of the Federal Deposit Insurance Act;

                 (i)    |_|  A  church  plan  that  is  excluded  from  the
                             definition of an  investment  company under section
                             3(c)(14) of the Investment Company Act of 1940;

                 (j)    |_|  Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).

                  If this  statement is filed  pursuant to Rule 13d-1 (c), check
this box. |X|

Item 4.  Ownership.

                  (a)      Amount beneficially owned:

                           Each of the Reporting  Persons owns the amount of the
                  Common Stock as set forth on the applicable cover page.

                  (b)      Percent of class:

                           Each of the Reporting  Persons owns the percentage of
                  the Common Stock as set forth on the applicable cover page.

                  (c)      Number of shares as to which such person has:

                           (i)     sole power to vote or to direct the vote:

                                   Each of the  Reporting  Persons has the sole
                           power to vote or direct the vote of the Common  Stock
                           as set forth on the applicable cover page.

                           (ii)    shared power to vote or to direct the vote:

                                   Each of the Reporting Persons has the shared
                           power to vote or direct the vote of the Common  Stock
                           as set forth on the applicable cover page.

                           (iii)    sole power to dispose or to direct the
                                    disposition of:

                                    Each of the  Reporting  Persons has the sole
                           power to  dispose or direct  the  disposition  of the
                           Common  Stock as set  forth on the  applicable  cover
                           page.

                           (iv)     shared power to dispose or to direct the
                           disposition of:

                                    Each of the Reporting Persons has the shared
                           power to  dispose or direct  the  disposition  of the
                           Common  Stock as set  forth on the  applicable  cover
                           page.

Item 5.  Ownership of Five Percent or Less of a Class.

                  Not applicable.

Item 6.  Ownership of More than Five Percent on Behalf of Another Person.

                  Investment management clients of each of the Reporting Persons
have the ultimate right to any dividends from Common Stock and the proceeds from
the sale of Common Stock.

Item 7.  Identification  and Classification of the Subsidiary Which Acquired the
         Security Being Reported on by the Parent Holding Company.

         The  following  are  subsidiaries  of DBAG and DWS Group  which hold
Common Stock    included    in   the   figures   on   the   cover    pages:
Deutsche Vermogensbildungsgesellschaft mbh and DWS Investment Management S.A.
Luxemburg.

Item 8.  Identification and Classification of Members of the Group.

         Not applicable.

Item 9.  Notice of Dissolution of Group.

         Not applicable.

Item 10. Certification.

         By signing  below I certify  that, to the best of my knowledge
and belief, the securities  referred to above were not acquired and are not held
for the purpose of or with the effect of changing or influencing  the control of
the  issuer  of the  securities  and  were  not  acquired  and are  not  held in
connection  with or as a participant in any  transaction  having that purpose or
effect.

<PAGE>

                                    SIGNATURE

             After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

Dated:  December 13, 2000



                                                 DEUTSCHE BANK AG



                                                 By:  /s/ Karl Heinz Baumann
                                                    ----------------------------
                                                    Name:   Karl Heinz Baumann
                                                    Title:  Director



                                                 By:  /s/ Rainer Grimberg
                                                    ----------------------------
                                                    Name:   Dr. Rainer Grimberg
                                                    Title:  Director

<PAGE>

                                                                       EXHIBIT 1


                     Consent of Deutsche Fonds Holding GmbH


             The  undersigned  agrees that the Schedule 13G executed by Deutsche
Bank AG to which this  statement is attached as an exhibit is filed on behalf of
Deutsche Bank AG, DWS  Investment  GmbH and Deutsche Fonds Holding GmbH pursuant
to Rule 13d-1(k)(1) of the Securities Exchange Act of 1934.

Dated:  December 13, 2000



                                           Deutsche Fonds Holding GmbH



                                           By: /s/ Guenther Kloke
                                              ----------------------------------
                                              Name:  Guenther Kloke
                                              Title: Business Risk Management
                                                     (Authorized Representative)



                                           By:  /s/ Ralf Ring
                                              ----------------------------------
                                              Name:   Ralf Ring
                                              Title:  Head of Compliance (DWS)

<PAGE>

                                                                       EXHIBIT 2

                         Consent of DWS Investment GmbH


             The  undersigned  agrees  that the  Schedule  13G  executed by
Deutsche  Bank AG to which this  statement is attached as an exhibit is filed on
behalf of Deutsche Bank AG,  Deutsche Fonds Holding GmbH and DWS Investment GmbH
pursuant to Rule 13d-1(k)(1) of the Securities Exchange Act of 1934.

Dated:  December 13, 2000



                                           DWS INVESTMENT GMBH



                                           By:  /s/ Guenther Kloke
                                              ---------------------------------
                                              Name:  Guenther Kloke
                                              Title: Business Risk Management
                                                     (Authorized Representative)



                                           By:  /s/ Ralf Ring
                                              ---------------------------------
                                              Name:   Ralf Ring
                                              Title:  Head of Compliance (DWS)



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