DEFINED ASSET FUNDS MUNICIPAL INSURED SERIES 2
S-6EL24, 1995-02-28
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   AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON FEBRUARY 28, 1995
                                        REGISTRATION NO. 33-
==============================================================================

                      SECURITIES AND EXCHANGE COMMISSION

                           WASHINGTON, D. C. 20549
                               _______________

                                   FORM S-6
                               _______________

                  FOR REGISTRATION UNDER THE SECURITIES ACT
                   OF 1933 OF SECURITIES OF UNIT INVESTMENT
                       TRUSTS REGISTERED ON FORM N-8B-2
                               _______________

A.  EXACT NAME OF TRUST:

                             DEFINED ASSET FUNDS
                          MUNICIPAL INSURED SERIES 2


B.  NAMES OF DEPOSITORS:

              MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED
                              SMITH BARNEY INC.
                           PAINEWEBBER INCORPORATED
                      PRUDENTIAL SECURITIES INCORPORATED
                          DEAN WITTER REYNOLDS INC.

C.  COMPLETE ADDRESSES OF DEPOSITORS' PRINCIPAL EXECUTIVE OFFICES:

MERRILL LYNCH, PIERCE, FENNER & SMITH                SMITH BARNEY INC.
           INCORPORATED                              388 GREENWICH ST.
          P.O. BOX 9051                                 23RD FLOOR
    PRINCETON, N.J. 08543-9051                     NEW YORK, N.Y. 10013


 PAINEWEBBER INCORPORATED     PRUDENTIAL SECURITIES      DEAN WITTER REYNOLDS
1285 AVE. OF THE AMERICAS         INCORPORATED                   INC.
   NEW YORK, N.Y. 10019        ONE SEAPORT PLAZA      TWO WORLD TRADE CENTER--
                                199 WATER STREET             59TH FLOOR
                              NEW YORK, N.Y.  10292     NEW YORK, N.Y. 10048


D.  NAMES AND COMPLETE ADDRESSES OF AGENTS FOR SERVICE:

   TERESA KONCICK, ESQ.       THOMAS D. HARMAN, ESQ.       LEE B. SPENCER, JR.
       P.O BOX 9051            388 GREENWICH STREET         ONE SEAPORT PLAZA
PRINCETON, N.J. 08543-9051     NEW YORK, N.Y. 10013         199 WATER STREET
                                                          NEW YORK, N.Y. 10292

                                                           COPIES TO
 DOUGLAS LOWE, ESQ.        ROBERT E. HOLLEY       PIERRE DE SAINT PHALLE, ESQ.
 130 LIBERTY STREET--      1200 HARBOR BLVD.          450 LEXINGTON AVENUE
    29TH FLOOR           WEEHAWKEN, N.J. 07087        NEW YORK, N.Y. 10017
NEW YORK, N. Y. 10006

E.  TITLE AND AMOUNT OF SECURITIES BEING REGISTERED:

 An indefinite number of Units of Beneficial Interest pursuant to Rule 24f-2
      promulgated under the Investment Company Act of 1940, as amended.

F.  PROPOSED MAXIMUM OFFERING PRICE TO THE  PUBLIC  OF  THE  SECURITIES  BEING
    REGISTERED:

                                  Indefinite

G.  AMOUNT OF FILING FEE:

                       $500 (as required by Rule 24f-2)

H.  APPROXIMATE DATE OF PROPOSED SALE TO THE PUBLIC:


 As soon as practicable after the acquisition and deposit of the underlying
securities.

THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT
SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS
REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH
SECTION 8(A)  OF THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION
STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING
PURSUANT TO SAID SECTION 8(A), MAY DETERMINE.
==============================================================================


          SUBJECT TO COMPLETION, PROSPECTUS DATED FEBRUARY 28, 1995

==============================================================================

                                                           DEFINED ASSET FUNDS
20,000 UNITS                                        MUNICIPAL INSURED SERIES 2
  ==============================================================================

     A FINAL PROSPECTUS FOR A PRIOR MUNICIPAL INSURED SERIES OF DEFINED ASSET
FUNDS IS HEREBY INCORPORATED BY REFERENCE AND USED AS A PRELIMINARY
PROSPECTUS FOR THIS INSURED SERIES.  THE NARRATIVE INFORMATION AND
STRUCTURE OF THE FINAL PROSPECTUS FOR THIS SERIES WILL BE SUBSTANTIALLY THE
SAME AS THAT OF THE PREVIOUS PROSPECTUS.  INFORMATION WITH RESPECT TO
PRICING, THE NUMBER OF UNITS, DATES AND SUMMARY INFORMATION REGARDING THE
CHARACTERISTICS OF SECURITIES TO BE DEPOSITED IN THIS SERIES IS NOT NOW
AVAILABLE AND WILL BE DIFFERENT FROM THAT SHOWN SINCE EACH SERIES HAS A
UNIQUE PORTFOLIO.  ACCORDINGLY, THE INFORMATION CONTAINED HEREIN WITH
REGARD TO THE PREVIOUS SERIES SHOULD BE CONSIDERED AS BEING INCLUDED FOR
INFORMATIONAL PURPOSES ONLY.  THE RATING OF THE UNITS OF THIS SERIES IS
EXPECTED TO BE COMPARABLE TO THAT OF THE UNITS OF THE PREVIOUS SERIES.
HOWEVER, THE ESTIMATED CURRENT AND LONG-TERM RETURNS FOR THIS SERIES WILL
DEPEND ON THE INTEREST RATES AND OFFERING SIDE EVALUATIONS OF THE
SECURITIES IN THIS SERIES AND MAY VARY MATERIALLY FROM THAT OF THE PREVIOUS
SERIES.  INVESTORS SHOULD CONTACT ACCOUNT EXECUTIVES OF THE UNDERWRITERS
WHO WILL BE INFORMED OF THE EXPECTED EFFECTIVE DATE OF THIS SERIES AND WHO
WILL BE SUPPLIED WITH COMPLETE INFORMATION WITH RESPECT TO SUCH SERIES ON
THE DAY OF AND IMMEDIATELY PRIOR TO THE EFFECTIVENESS OF THE REGISTRATION
STATEMENT RELATING TO UNITS OF THIS SERIES.


     INFORMATION CONTAINED HEREIN IS SUBJECT TO COMPLETION OR AMENDMENT.  A
REGISTRATION STATEMENT RELATING TO THESE SECURITIES HAS BEEN FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION.  THESE SECURITIES MAY NOT BE SOLD NOR
MAY OFFERS TO BUY BE ACCEPTED PRIOR TO THE TIME THE REGISTRATION STATEMENT
BECOMES EFFECTIVE.  THIS PROSPECTUS SHALL NOT CONSTITUTE AN OFFER TO SELL
OR THE SOLICITATION OF AN OFFER TO BUY NOR SHALL THERE BE ANY SALE OF THESE
SECURITIES IN ANY STATE IN WHICH SUCH OFFER, SOLICITATION OR SALE WOULD BE
UNLAWFUL PRIOR TO REGISTRATION OR QUALIFICATION UNDER THE SECURITIES LAWS
OF ANY SUCH STATE.


                                   PART II

            ADDITIONAL INFORMATION NOT INCLUDED IN THE PROSPECTUS

     A.  The following information relating to the Depositors is
incorporated by reference to the SEC filings indicated and made a part of
this Registration Statement.
                                                      SEC FILE OR
                                                   IDENTIFICATION NO.
                                                   __________________

I.  Bonding Arrangements and Date of Organization of the Depositors filed
    pursuant to Items A and B of Part II of the Registration Statement on
    Form S-6 under the Securities Act of 1933:

         Merrill Lynch, Pierce, Fenner & Smith Incorporated       2-52691
         Prudential Securities Incorporated                       2-61418
         Smith Barney Inc.                                       33-29106
         Dean Witter Reynolds Inc.                                2-60599
         PaineWebber Incorporated                                 2-87965

II. Information as to Officers and Directors of the Depositors filed
    pursuant to Schedules A and D of Form BD under Rules 15b1-1 and 15b3-1
    of the Securities Exchange Act of 1934:

         Merrill Lynch, Pierce, Fenner & Smith Incorporated        8-7221
         Prudential Securities Incorporated                       8-12321
         Smith Barney Inc.                                         8-8177
         Dean Witter Reynolds Inc.                                8-14172
         PaineWebber Incorporated                                 8-16267


III. Charter documents of the Depositors filed as Exhibits to the
     Registration Statement on Form S-6 under the Securities Act of 1933
     (Charter, By-Laws):

         Merrill Lynch, Pierce, Fenner & Smith
           Incorporated                                  2-73866, 2-77549
         Prudential Securities Incorporated              2-86941, 2-86941
         Smith Barney Inc.                                       33-20499
         Dean Witter Reynolds Inc.                       2-60599, 2-86941
         PaineWebber Incorporated                        2-87965, 2-87965

     B.  The Internal Revenue Service Employer Identification Numbers of
the Sponsors and Trustee are as follows:

         Merrill Lynch, Pierce, Fenner & Smith Incorporated    13-5674085
         Prudential Securities Incorporated                    13-6134767
         Smith Barney Inc.                                     13-1912900
         Dean Witter Reynolds Inc.                             94-1671384
         PaineWebber Incorporated                              13-2638166
         The Chase Manhattan Bank, N.A.                        13-2633612



                                 UNDERTAKING

     The Sponsors undertake that they will not instruct the Trustee to
accept from (i)  Financial Guaranty Insurance Company, Municipal Bond
Insurance Association or any other insurance company affiliated with any of
the Sponsors, in settlement of any claim, less than an amount sufficient to
pay any principal or interest (and, in the case of a taxability redemption,
premium) then due on any Security in accordance with the municipal bond
guaranty insurance policy attached to such Security or (ii) any affiliate
of the Sponsors who has any obligation with respect to any Security, less
than the full amount due pursuant to the obligation unless such
instructions have been approved by the Securities and Exchange Commission
pursuant to Rule 17d-1 under the Investment Company Act of 1940.


                                     II-1


     Supplemented final prospectuses from Defined Asset Funds, Municipal
Insured Series (Reg. No. 33-54565) (which is incorporated herein by
reference) may be used as preliminary prospectuses for this Series.

                      CONTENTS OF REGISTRATION STATEMENT

 THE REGISTRATION STATEMENT ON FORM S-6 COMPRISES  THE  FOLLOWING  PAPERS  AND
DOCUMENTS:

 The facing sheet of Form S-6.
 The Cross-Reference Sheet (incorporated by reference to the Cross-
   Reference Sheet to the Registration Statement of Municipal Investment
   Trust Fund, First Insured Series, 1933 Act File No. 2-87965).
 The Prospectus.
 Additional Information not included in the Prospectus (Part II).
 *Consent of independent public accountants.

 The following exhibits:

      1.1        -- Form of Trust Indenture (incorporated by reference
                    to Exhibit 1.1 to the Registration Statement of Municipal
                    Investment Trust Fund, Insured Series-195, Defined
                    Asset Funds, 1933 Act File No. 33-50003).

      1.1.1      -- Form of Standard Terms and Conditions of Trust Effective
                    October 21, 1993 (incorporated by reference to Exhibit
                    1.1.1 to the Registration Statement of Municipal
                    Investment Trust Fund, Multistate Series-48, Defined
                    Asset Funds, 1933 Act File No. 33-50247).

      1.2        -- Form of Master Agreement Among Underwriters (incorporated
                    by reference to Exhibit 1.2 to the Registration
                    Statement of The Corporate Income Fund, One Hundred
                    Ninety-Fourth Monthly Payment Series, 1933 Act File No.
                    2-90925).

      1.3       --  Form of Portfolio Insurance policy (incorporated by
                    reference to Exhibit 1.3 to the Registration Statement
                    of Municipal Investment Trust Fund, Thirty-Eighth
                    Insured Series, 1933 Act File No. 2-96953).

      1.4       --  Form of commitment letter relating to  issuance  of
                    Permanent Insurance, with form of Permanent Insurance
                    policy attached (incorporated by reference to Exhibit
                    1.4 to the Registration Statement of Municipal
                    Investment Trust Fund, Thirty-Eighth Insured Series,
                    1933 Act File No. 2-96953).

      2.1       --  Form of Certificate of Beneficial Interest (included in
                    Exhibit 1.1.1).

     *3.1       --  Opinion of counsel as to the legality of the securities
                    being issued including their consent to the use of
                    their names under the headings "Taxes" and
                    "Miscellaneous--Legal Opinion" in the Prospectus.


     *4.1.1     --  Consent of the Evaluator.

     *4.1.2     --  Consent of the Rating Agency.


__________

  * To be filed with Amendment to Registration Statement.


                                     R-1


                                  SIGNATURES

     PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THE
REGISTRANT HAS DULY CAUSED THIS REGISTRATION STATEMENT OR AMENDMENT TO THE
REGISTRATION STATEMENT TO BE SIGNED ON ITS BEHALF BY THE UNDERSIGNED
THEREUNTO DULY AUTHORIZED IN THE CITY OF NEW YORK AND STATE OF NEW YORK ON
THE 28TH DAY OF FEBRUARY, 1995.


            Signatures appear on pages R-3, R-4, R-5, R-6 and R-7.

     A majority of the members of the Board of Directors of Merrill Lynch,
Pierce, Fenner & Smith Incorporated has signed this Registration Statement
or Amendment to the Registration Statement pursuant to Powers of Attorney
authorizing the person signing this Registration Statement or Amendment to
the Registration Statement to do so on behalf of such members.

     A majority of the members of the Board of Directors of Prudential
Securities Incorporated has signed this Registration Statement or Amendment
to the Registration Statement pursuant to Powers of Attorney authorizing
the person signing this Registration Statement or Amendment to the
Registration Statement to do so on behalf of such members.

     A majority of the members of the Board of Directors of Smith Barney
Inc. has signed this Registration Statement or Amendment to the
Registration Statement pursuant to Powers of Attorney authorizing the
person signing this Registration Statement or Amendment to the Registration
Statement to do so on behalf of such members.

     A majority of the members of the Board of Directors of Dean Witter
Reynolds Inc. has signed this Registration Statement or Amendment to the
Registration Statement pursuant to Powers of Attorney authorizing the
person signing this Registration Statement or Amendment to the Registration
Statement to do so on behalf of such members.

     A majority of the members of the Executive Committee of the Board of
Directors of PaineWebber Incorporated has signed this Registration
Statement or Amendment to the Registration Statement pursuant to Powers of
Attorney authorizing the person signing this Registration Statement or
Amendment to the Registration Statement to do so on behalf of such members.


                                     R-2


MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED
               DEPOSITOR


By the following persons, who constitute a        Powers of Attorney have been
   majority of the Board of Directors of          filed under Form SE and
   Merrill Lynch, Pierce, Fenner & Smith          the following 1933 Act
   Incorporated:                                  File Number: 33-43466

       HERBERT M. ALLISON, JR.
       BARRY S. FRIEDBERG
       EDWARD L. GOLDBERG
       STEPHEN L. HAMMERMAN
       JEROME P. KENNEY
       DAVID H. KOMANSKY
       DANIEL T. NAPOLI
       THOMAS H. PATRICK
       JOHN L. STEFFENS
       DANIEL P. TULLY
       ROGER M. VASEY
       ARTHUR H. ZEIKEL








       By  ERNEST V. FABIO
          (As authorized signatory for
          Merrill Lynch, Pierce, Fenner & Smith Incorporated
          and Attorney-in-fact for the persons listed above)


                                     R-3


   PRUDENTIAL SECURITIES INCORPORATED
          DEPOSITOR


   By the following persons,                Powers of Attorney have been
      who constitute a majority of            filed under Form SE and
      the Executive Committee of              the following 1933 Act
      the Board of Directors of               File Number: 33-41631
      Prudential Securities Incorporated:


       JAMES T. GAHAN
       ALAN D. HOGAN
       HOWARD A. KNIGHT
       GEORGE A. MURRAY
       LELAND B. PATON
       HARDWICK SIMMONS




       By  RICHARD R. HOFFMANN
          (As authorized signatory for
          Prudential Securities Incorporated
          and Attorney-in-fact for the persons listed above)


                                     R-4


   SMITH BARNEY INC.
      DEPOSITOR


   By the following persons,                Powers of Attorney have
      who constitute a majority of             been filed under the
      the Board of Directors of                1933 Act File
      Smith Barney Inc.:                       Numbers: 33-49753
                                               and 33-51607

       STEVEN D. BLACK
       JAMES BOSHART III
       ROBERT A. CASE
       JAMES DIMON
       ROBERT DRUSKIN
       ROBERT F. GREENHILL
       JEFFREY LANE
       ROBERT H. LESSIN
       JACK L. RIVKIN


       By  GINA LEMON
          (As authorized signatory for
          Smith Barney Inc. and
          Attorney-in-fact for the persons listed above)


                                     R-5


   DEAN WITTER REYNOLDS INC.
          DEPOSITOR



   By the following persons,         Powers of Attorney have been
      who constitute a majority of     filed under Form SE and
      the Board of Directors of        the following 1933 Act
      Dean Witter Reynolds Inc.:       File Number: 33-17085

          NANCY DONOVAN
          CHARLES A. FIUMEFREDDO
          JAMES F. HIGGINS
          STEPHEN R. MILLER
          PHILIP J. PURCELL
          THOMAS C. SCHNEIDER
          WILLIAM B. SMITH




          By  MICHAEL D. BROWNE
             (As authorized signatory for
             Dean Witter Reynolds Inc. and
             Attorney-in-fact for the persons listed above)


                                     R-6


   PAINEWEBBER INCORPORATED
      DEPOSITOR



   By the following persons, who                Powers of Attorney have
      constitute a majority of the                been filed under
      Executive Committee of the                  Form SE and the
      Board of Directors of                       following 1933 Act
      PaineWebber Incorporated:                   File Number: 33-55073

              PAUL B. GUENTHER
              DONALD B. MARRON
              JOSEPH J. GRANO, JR.
              LEE FENSTERSTOCK

              By  ROBERT E. HOLLEY
                 (As authorized signatory for
                 PaineWebber Incorporated and
                 Attorney-in-fact for the persons listed above)


                                     R-7



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