COULTER PHARMACEUTICALS INC
DEF 14A, 1999-04-23
PHARMACEUTICAL PREPARATIONS
Previous: SEPARATE ACCOUNT ONE OF NORTHERN LIFE INSURANCE CO, 485BPOS, 1999-04-23
Next: SOURCE INFORMATION MANAGEMENT CO, S-2, 1999-04-23



<PAGE>   1
                            SCHEDULE 14A INFORMATION
                Proxy Statement Pursuant to Section 14(a) of the
                        Securities Exchange Act of 1934
(Amendment No.   )

Filed by the Registrant                     [X]
Filed by a Party other than the Registrant  [ ]

Check the appropriate box:

[ ]     Preliminary Proxy Statement
[ ]     Confidential, for Use of the Commission Only (as permitted by 
        Rule 14a-6(e)(2))
[ ]     Definitive Proxy Statement
[ ]     Definitive Additional Materials
[ ]     Soliciting Material Pursuant to Section 240.14a-11(c) or 
        Section 240.14a-12


                          Coulter Pharmaceutical, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)


- --------------------------------------------------------------------------------
     (Name of Person(s) Filing Proxy Statement if Other Than the Registrant)


Payment of Filing Fee (Check the appropriate box)

[ ]     No fee required.
[ ]     Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

1.      Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------

2.      Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------

3.      Per unit price or other underlying value of transaction computed
        pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the
        filing fee is calculated and state how it was determined):

- --------------------------------------------------------------------------------

4.      Proposed maximum aggregate value of transaction:

- --------------------------------------------------------------------------------

5.      Total fee paid:

- --------------------------------------------------------------------------------


[ ]     Fee paid previously with preliminary materials.

[ ]     Check box if any part of the fee is offset as provided by Exchange Act
        Rule 0-11(a)(2) and identify the filing for which the offsetting fee was
        paid previously. Identify the previous filing by registration statement
        number, or the Form or Schedule and the date of its filing.

6.      Amount Previously Paid:

- --------------------------------------------------------------------------------

7.      Form, Schedule or Registration Statement No.:

- --------------------------------------------------------------------------------

8.      Filing Party:

- --------------------------------------------------------------------------------

9.      Date Filed:




<PAGE>   2
 
                          COULTER PHARMACEUTICAL, INC.
                             600 GATEWAY BOULEVARD
                     SOUTH SAN FRANCISCO, CALIFORNIA 94080
                            ------------------------
 
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON MAY 21, 1999
 
TO THE STOCKHOLDERS OF COULTER PHARMACEUTICAL, INC.:
 
     NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of Coulter
Pharmaceutical, Inc., a Delaware corporation (the "Company"), will be held on
Friday, May 21, 1999 at 10:00 a.m. local time at the Hyatt Regency Hotel (San
Francisco Airport), 1333 Bayshore Highway, Burlingame, California 94010 for the
following purpose:
 
     1. To elect directors to serve for the ensuing year and until their
        successors are elected.
 
     2. To approve the Company's 1996 Equity Incentive Plan, as amended, to
        increase the aggregate number of shares of Common Stock authorized for
        issuance under such plan by 2,000,000 shares.
 
     3. To ratify the selection of Ernst & Young LLP as independent auditors of
        the Company for its fiscal year ending December 31, 1999.
 
     4. To transact such other business as may properly come before the meeting
        or any adjournment or postponement thereof.
 
     The foregoing items of business are more fully described in the Proxy
Statement accompanying this Notice.
 
     The Board of Directors has fixed the close of business on Wednesday, March
24, 1999, as the record date for the determination of stockholders entitled to
notice of and to vote at this Annual Meeting and at any adjournment or
postponement thereof.
 
                                          By Order of the Board of Directors
                                          /s/ James C. Kitch
                                          James C. Kitch
                                          Secretary
 
South San Francisco, California
April 27, 1999
 
     ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON.
WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE, SIGN AND
RETURN THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE IN ORDER TO ENSURE YOUR
REPRESENTATION AT THE MEETING. A RETURN ENVELOPE (WHICH IS POSTAGE PREPAID IF
MAILED IN THE UNITED STATES) IS ENCLOSED FOR THAT PURPOSE. EVEN IF YOU HAVE
GIVEN YOUR PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING. PLEASE
NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK OR OTHER
NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST OBTAIN FROM THE RECORD
HOLDER A PROXY ISSUED IN YOUR NAME.
<PAGE>   3
 
                          COULTER PHARMACEUTICAL, INC.
                             600 GATEWAY BOULEVARD
                     SOUTH SAN FRANCISCO, CALIFORNIA 94080
                            ------------------------
 
                                PROXY STATEMENT
                            ------------------------
 
                       FOR ANNUAL MEETING OF STOCKHOLDERS
                                  MAY 21, 1999
 
                 INFORMATION CONCERNING SOLICITATION AND VOTING
 
GENERAL
 
     The enclosed proxy is solicited on behalf of the Board of Directors of
Coulter Pharmaceutical, Inc., a Delaware corporation (the "Company"), for use at
the Annual Meeting of Stockholders to be held on May 21, 1999, at 10:00 a.m.
local time (the "Annual Meeting"), or at any adjournment or postponement
thereof, for the purposes set forth herein and in the accompanying Notice of
Annual Meeting. The Annual Meeting will be at the Hyatt Regency Hotel (San
Francisco Airport), 1333 Bayshore Highway, Burlingame, California 94010. The
Company intends to mail this proxy statement and accompanying proxy card on or
about April 27, 1999, to all stockholders entitled to vote at the Annual
Meeting.
 
SOLICITATION
 
     The Company will bear the entire cost of solicitation of proxies, including
preparation, assembly, printing and mailing of this proxy statement, the proxy
and any additional information furnished to stockholders. Copies of solicitation
materials will be furnished to banks, brokerage houses, fiduciaries and
custodians holding in their names shares of Common Stock beneficially owned by
others to forward to such beneficial owners. The Company may reimburse persons
representing beneficial owners of Common Stock for their costs of forwarding
solicitation materials to such beneficial owners. Original solicitation of
proxies by mail may be supplemented by telephone, telegram or personal
solicitation by directors, officers or other regular employees of the Company.
No additional compensation will be paid to directors, officers or other regular
employees for such services.
 
VOTING RIGHTS AND OUTSTANDING SHARES
 
     Only holders of record of Common Stock at the close of business on
Wednesday, March 24, 1999 will be entitled to notice of and to vote at the
Annual Meeting. At the close of business on Wednesday, March 24, 1999 the
Company had outstanding and entitled to vote 16,746,397 shares of Common Stock.
 
     Each holder of record of Common Stock on such date will be entitled to one
vote for each share held on all matters to be voted upon at the Annual Meeting.
 
     All votes will be tabulated by the inspector of election appointed for the
meeting, who will separately tabulate affirmative and negative votes,
abstentions and broker non-votes. Abstentions will be counted toward the
tabulation of votes cast on proposals presented to the stockholders and will
have the same effect as negative votes. Broker non-votes are counted toward a
quorum, but are not counted for any purpose in determining whether a matter has
been approved.
 
REVOCABILITY OF PROXIES
 
     Any person giving a proxy pursuant to this solicitation has the power to
revoke it at any time before it is voted. It may be revoked by filing with the
Secretary of the Company at the Company's principal executive office, 600
Gateway Boulevard, South San Francisco, California 94080, a written notice of
revocation or a duly
 
                                        1
<PAGE>   4
 
executed proxy bearing a later date, or it may be revoked by attending the
meeting and voting in person. Attendance at the meeting will not, by itself,
revoke a proxy.
 
STOCKHOLDER PROPOSALS
 
     The deadline for submitting a stockholder proposal for inclusion in the
Company's proxy statement and form of proxy for the Company's 2000 annual
meeting of stockholders pursuant to Rule 14a-8 of the Securities and Exchange
Commission is December 28, 1999. The deadline for submitting a stockholder
proposal or nomination for director that is not to be included in such proxy
statement and proxy is not later than the close of business on March 22, 2000
nor earlier than February 20, 2000. Stockholders are advised to review the
Company's By-laws, which contain additional requirements with respect to advance
notice of stockholder proposals and director nominations.
 
                                   PROPOSAL 1
 
                             ELECTION OF DIRECTORS
 
     There are eight (8) nominees for the eight (8) Board positions presently
authorized in the Company's By-laws. Each director to be elected will hold
office until the next annual meeting of stockholders and until his/her successor
is elected and has qualified, or until such director's earlier death,
resignation or removal. Each nominee listed below is currently a director of the
Company, all eight (8) directors have been elected by the stockholders.
 
     Shares represented by executed proxies will be voted, if authority to do so
is not withheld, for the election of the eight (8) nominees named below. In the
event that any nominee should be unavailable for election as a result of an
unexpected occurrence, such shares will be voted for the election of such
substitute nominee as management may propose. Each person nominated for election
has agreed to serve if elected and management has no reason to believe that any
nominee will be unable to serve.
 
     Directors are elected by a plurality of the votes present in person or
represented by proxy and entitled to vote.
 
                       THE BOARD OF DIRECTORS RECOMMENDS
                     A VOTE IN FAVOR OF EACH NAMED NOMINEE
 
NOMINEES
 
     The names of the nominees and certain information about them are set forth
below:
 
<TABLE>
<CAPTION>
                   NAME                     AGE          POSITION HELD WITH THE COMPANY
                   ----                     ---          ------------------------------
<S>                                         <C>   <C>
                                                  President, Chief Executive Officer and
Michael F. Bigham.........................  41    Director
Arnold Oronsky, Ph.D......................  58    Chairman of the Board
Brian G. Atwood...........................  46    Director
Joseph R. Coulter, III....................  39    Director
Donald L. Lucas...........................  69    Director
Robert Momsen.............................  52    Director
George J. Sella, Jr.......................  70    Director
Sue Van...................................  52    Director
</TABLE>
 
     Michael F. Bigham has served as President, Chief Executive Officer and a
director of the Company since July 1996. Mr. Bigham served as Executive Vice
President of Operations from April 1994 to June 1996 and Chief Financial Officer
from April 1989 to June 1996 at Gilead Sciences, Inc., a biotechnology company.
While at Gilead, he also served as Vice President of Corporate Development from
July 1988 to March 1992. Mr. Bigham was Co-head of Healthcare Investment Banking
for Hambrecht & Quist LLC, an investment banking firm where he was employed from
1984 to 1988. Mr. Bigham is a member of the Board of Directors of
 
                                        2
<PAGE>   5
 
Datron Systems, Inc., a publicly-held electronics company, LJL BioSystems, Inc.,
a publicly-held scientific instrumentation company and two privately-held
companies.
 
     Arnold Oronsky, Ph.D. has served as Chairman of the Board of Directors of
the Company since its inception in February 1995. From February 1995 to July
1996, Dr. Oronsky also served as President and Chief Executive Officer of the
Company. Since March 1994, Dr. Oronsky has been a general partner at InterWest
Partners, a private venture capital firm. From February 1997 to December 1997,
Dr. Oronsky served as President and Chief Executive Officer at Coulter Cellular
Therapies, a private biotechnology company, and is currently Chairman of the
Board. Since December 1996, Dr. Oronsky has been Chief Executive Officer and a
member of the board at Dynavax, a private biotechnology company. From 1984 to
1994, Dr. Oronsky served as Vice President for Discovery Research at Lederle
Laboratories, a pharmaceutical division of American Cyanamid, Inc. Dr. Oronsky
has won numerous grants and awards and has published over 125 scientific
articles. Since 1988, Dr. Oronsky has served as a senior lecturer in the
Department of Medicine at John Hopkins Medical School. Dr. Oronsky is a member
of the Board of Directors of Corixa Corp., a publicly held biotechnology
company.
 
     Brian Atwood has served as a director of the Company since April 1996. From
March to December 1995, Mr. Atwood was a consultant on business development to
the Company. Since October 1997, Mr. Atwood has been a General Partner of
Brentwood Venture Capital, a private venture capital firm, and since November
1995 he served as a Venture Partner at the firm. He was a founder and served as
President and Chief Executive Officer from December 1993 to May 1995 and Vice
President, Operations from July 1988 to November 1993 of Glycomed Incorporated,
a company dedicated to the discovery and development of novel drugs based on
complex carbohydrates. From January 1986 to June 1987, Mr. Atwood was a Director
at Perkin-Elmer/Cetus Instrument Systems, a joint venture formed by Perkin-Elmer
Corp. and Cetus Corporation, where he oversaw the development and launch of
three biotechnology instrument research systems. Mr. Atwood currently serves as
Chairman of one privately held company.
 
     Joseph R. Coulter, III has served as a director of the Company since
December 1996. Mr. Coulter was employed by Coulter Corporation until December
1997. Coulter Corporation was acquired by Beckman Instruments in October 1997.
During his 18 years at Coulter Corporation, Mr. Coulter was most recently a
director of Coulter Corporation, Executive Vice President, Director of
Information Systems, and Program Manager for Research and Development. Mr.
Coulter also serves as an officer of a privately held resort in the Florida
Keys.
 
     Donald L. Lucas has served as a director of the Company since April 1996.
Since 1967, Mr. Lucas has been actively engaged in venture capital activities as
a private individual. Mr. Lucas currently serves as a director of Cadence Design
Systems, Inc., Macromedia, Inc., Oracle Corporation, Transcend Services, Inc.
and Tricord Systems, Inc.
 
     Robert Momsen has served as a director of the Company since its inception
in February 1995. Since August 1982, Mr. Momsen has been a General Partner at
InterWest Partners, a private venture capital firm. From 1977 to 1981, Mr.
Momsen served as General Manager and Chief Financial Officer of Life Instruments
Corporation, a medical diagnostic imaging company that he co-founded. Mr. Momsen
currently serves as a director of ArthroCare Corp., COR Therapeutics, Inc.,
Innovasive Devices, Inc., Integ, Inc., Urologix, Inc. and ProGenitor, Inc. Mr.
Momsen also serves as a director of several private companies.
 
     George J. Sella, Jr. has served as a director of the Company since December
1996. From January 1983 to his retirement in April 1993, Mr. Sella served as
Chief Executive Officer of American Cyanamid Company, a chemical, agricultural
and medical products company. From September 1979 to January 1991, Mr. Sella
served as President of American Cyanamid. From May 1984 to April 1993, he served
as Chairman of the Board of Directors of American Cyanamid. Mr. Sella currently
serves as a director of Union Camp Corporation, Bush Boake Allen, Inc. and
Equitable Companies, Inc.
 
     Sue Van has served as a director of the Company since its inception in
February 1995. Since December 1997, she has been Trustee of the Wallace H.
Coulter Trust. Ms. Van was employed by Coulter Corporation until December 1997.
During her 22 years at Coulter Corporation, she was most recently a director,
Executive
 
                                        3
<PAGE>   6
 
Vice President, Chief Financial Officer and Treasurer. Coulter Corporation was
acquired by Beckman Instruments in October 1997.
 
BOARD COMMITTEES AND MEETINGS
 
     During the fiscal year ended December 31, 1998 the Board of Directors held
four meetings. The Board has an Audit Committee and a Compensation Committee.
 
     The Audit Committee meets with the Company's independent auditors at least
annually to review the results of the annual audit and discuss the financial
statements; recommends to the Board the independent auditors to be retained; and
receives and considers the accountants' comments as to controls, adequacy of
staff and management performance and procedures in connection with audit and
financial controls. The Audit Committee is composed of three non-employee
directors: Brian Atwood, Donald Lucas and Sue Van. It met once during such
fiscal year.
 
     The Compensation Committee makes recommendations concerning salaries and
incentive compensation, awards stock options to employees and consultants under
the Company's stock option plans and otherwise determines compensation levels
and performs such other functions regarding compensation as the Board may
delegate. The Compensation Committee is composed of four non-employee directors:
Arnold Oronsky, Donald Lucas, Robert Momsen and Sue Van. It met once during such
fiscal year.
 
     During the fiscal year ended December 31, 1998, each Board member attended
75% or more of the aggregate of the meetings of the Board and of the committees
on which he/she served, held during the period for which he/she was a director
or committee member, respectively.
 
                                   PROPOSAL 2
 
             APPROVAL OF THE 1996 EQUITY INCENTIVE PLAN, AS AMENDED
 
     In December 1996, the Board of Directors adopted, and the stockholders
subsequently approved, the Company's 1996 Equity Incentive Plan (the "1996
Plan"). In April 1998, the Board approved an amendment to the 1996 Plan, subject
to stockholder approval, to enhance the flexibility of the Board and the
Compensation Committee in granting stock options to the Company's employees. The
amendment increased the number of shares authorized for issuance under the 1996
Plan by 2,000,000 shares, from a total of 2,800,000 shares to a total of
4,800,000 shares. The Board adopted this amendment to ensure that the Company,
as it grows, can continue to grant stock options to employees at levels
determined appropriate by the Board and the Compensation Committee.
 
     At December 31, 1998, options (net of canceled or expired options) covering
an aggregate of 2,082,937 shares of the Company's Common Stock had been granted
under the 1996 Plan, and 717,063 shares (plus any shares that might in the
future be returned to the Plan as a result of cancellations or expiration of
options) remained available for future grant under the 1996 Plan. Options to
purchase an additional 138,000 shares and 39,000 shares were granted under the
1996 Plan in February 1999 and March 1999, respectively. During the last fiscal
year, under the 1996 Plan, the Company granted to all current executive officers
as a group options to purchase 150,000 shares at an exercise price $24.125 per
share, to all employees (excluding executive officers) as a group options to
purchase 896,300 shares at exercise prices ranging from $19.375 to $29.875 per
share and to all current directors who are not officers as a group options to
purchase 5,000 shares at an exercise price of $22.75. For further information
regarding stock option grants, see "Executive Compensation -- Stock Option
Grants and Exercises."
 
     Stockholders are requested in this Proposal 2 to approve the 1996 Plan, as
amended. If the stockholders fail to approve this Proposal 2, there will only be
approximately 540,000 shares available for future grant under the 1996 Plan
(before accounting for canceled or expired options). The affirmative vote of the
holders of a majority of the shares present in person or represented by proxy
and entitled to vote at the meeting will be required to approve the 1996 Plan,
as amended. Abstentions will be counted toward the tabulation of votes cast on
proposals presented to the stockholders and will have the same effect as
negative votes. Broker non-
 
                                        4
<PAGE>   7
 
votes are counted towards a quorum, but are not counted for any purpose in
determining whether this matter has been approved.
 
                       THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 2
 
     The essential features of the 1996 Plan, as amended, are outlined below:
 
GENERAL
 
     The 1996 Plan provides for the granting to employees (including officers
and employee directors) of incentive stock options within the meaning of Section
422 of the Internal Revenue Code, as amended (the "Code"), and for the granting
of nonstatutory stock options, restricted stock purchase awards, and stock
bonuses (collectively, "Stock Awards") to employees, directors of and
consultants to the Company. To date, only stock options have been awarded under
the 1996 Plan.
 
PURPOSE
 
     The 1996 Plan was adopted to provide a means by which selected directors,
officers and employees of and consultants to the Company and its affiliates
could be given an opportunity to purchase stock in the Company, to assist in
retaining the services of employees holding key positions, to secure and retain
the services of persons capable of filling such positions and to provide
incentives for such persons to exert maximum efforts for the success of the
Company.
 
ADMINISTRATION
 
     The Company's Board of Directors has delegated administration of the 1996
Plan to the Compensation Committee (the "Committee"). The Committee membership
is intended to satisfy the provisions of Rule 16b-3 promulgated under the
Securities Exchange Act of 1934, as amended, and Code section 162(m), in each
case to the extent applicable. The Committee has the authority, subject to the
terms of the 1996 Plan, to determine the recipients and types of awards to be
granted, the terms of the awards granted, including the exercise price, number
of shares subject to the award, the exercisability thereof, and the form of
consideration payable upon exercise.
 
ELIGIBILITY
 
     Incentive stock options may be granted under the 1996 Plan only to selected
employees (including officers and directors who are salaried employees) of the
Company and its affiliates. Selected employees (including officers), directors
and consultants are eligible to receive Stock Awards (other than incentive stock
options) under the 1996 Plan.
 
     No incentive stock option may be granted under the 1996 Plan to any person
who, at the time of the grant, owns (or is deemed to own) stock possessing more
than 10% of the total combined voting power of the Company or any affiliate of
the Company, unless the incentive stock option exercise price is at least 110%
of the fair market value of the stock subject to the incentive stock option on
the date of grant, and the term of the option does not exceed five years from
the date of grant. The aggregate fair market value, determined at the time of
grant, of the shares of Common Stock with respect to which incentive stock
options are exercisable for the first time by an optionee during any calendar
year (under all such plans of the Company and its affiliates) may not exceed
$100,000. No optionee shall be eligible for option grants under the 1996 Plan
covering more than 280,000 shares of Common Stock in any calendar year.
 
STOCK SUBJECT TO THE 1996 PLAN
 
     As amended, 4,800,000 shares of the Company's Common Stock are authorized
for issuance under the 1996 Plan. If options granted under the 1996 Plan expire
or otherwise terminate without being exercised, the Common Stock not purchased
pursuant to such options again becomes available for issuance under the 1996
Plan.
                                        5
<PAGE>   8
 
TERMS OF OPTIONS
 
     The following is a description of the permissible terms of options under
the 1996 Plan. Individual option grants may be more restrictive as to any or all
of the permissible terms described below.
 
     Exercise Price; Payment. The exercise price of incentive stock options
under the 1996 Plan generally may not be less than the fair market value of the
Common Stock subject to the option on the date of the option grant, and in some
cases (see "Eligibility" above), may not be less than 110% of such fair market
value. The exercise price of nonstatutory options under the 1996 Plan generally
may not be less than 85% of the fair value of the Common Stock on the date of
option grant. The exception to these general rules is when the option relates to
the assumption or substitution of another option as permitted under Section 424
of the Code.
 
     In the event of a decline in the value of the Company's Common Stock, the
Board has the authority to offer employees the opportunity to replace
outstanding higher priced options, whether incentive or nonstatutory, with new
lower priced options. To the extent required by Section 162(m), an option
repriced under the 1996 Plan is deemed to be canceled and a new option granted.
Both the option deemed to be canceled and the new option deemed to be granted
will be counted against the 280,000 share limitation. To date, the Company has
not repriced any outstanding options, and does not currently have any intention
of doing so.
 
     The exercise price of options granted under the 1996 Plan must be paid
either: (a) in cash at the time the option is exercised; or (b) at the
discretion of the Board, (i) by delivery of other Common Stock of the Company,
(ii) pursuant to a deferred payment arrangement, or (c) in any other form of
legal consideration acceptable to the Board.
 
     Option Exercise. Options granted under the 1996 Plan may become exercisable
in cumulative increments ("vest") as determined by the Board. Certain shares
covered by currently outstanding options under the 1996 Plan vest at the rate of
 1/4 of the option total on the first anniversary of the option grant with
subsequent vesting at a rate of 1/48 per month thereafter until fully vested
during the optionee's employment or services as a consultant or a director.
Other shares covered by currently outstanding options under the 1996 Plan vest
at the rate 1/48 per month until fully vested during the optionee's employment
or services as a consultant or a director. Shares covered by options granted in
the future under the 1996 Plan may be subject to different vesting terms. The
Board has the power to accelerate the time during which an option may be
exercised. In addition, options granted under the 1996 Plan may permit exercise
prior to vesting, but in such event the optionee may be required to enter into
an early exercise stock purchase agreement that allows the Company to repurchase
shares not yet vested at their exercise price should the optionee's service to
the Company or an affiliate terminate before vesting. To the extent provided by
the terms of an option, an optionee may satisfy any federal, state or local tax
withholding obligation relating to the exercise of such option by a cash payment
upon exercise, by authorizing the Company to withhold a portion of the stock
otherwise issuable to the optionee, by delivering already-owned stock of the
Company or by a combination of these means.
 
     Term. The maximum term of options under the 1996 Plan is 10 years, except
that in certain cases (see "Eligibility") the maximum term is five years.
Options under the 1996 Plan terminate three months after termination of the
optionee's employment or relationship as a consultant or director of the Company
or any affiliate of the Company, unless such termination is due to such person's
disability, in which case the option may, but need not, provide that it may be
exercised at any time within twelve months of such termination or for up to
eighteen months if such termination is due to death. Individual options by their
terms may provide for exercise within a longer or shorter period of time
following termination of the optionee's service to the Company or an affiliate.
The option term will be extended in the event that exercise of the option within
these periods is prohibited for specified reasons.
 
TERMS OF STOCK BONUSES AND PURCHASES OF RESTRICTED STOCK
 
     Purchase Price; Payment. The Board will determine the purchase price under
each restricted stock purchase agreement, but the purchase price may not be less
than 85% of the stock's fair market value on the date the Board makes the award.
The purchase price of stock subject to a restricted stock purchase agreement
must be paid either: (i) in cash at the time of purchase; (ii) at the discretion
of the Board, according to a
 
                                        6
<PAGE>   9
 
deferred payment or other arrangement with the person to whom the Common Stock
is sold; or (iii) in any other form of legal consideration that may be
acceptable to the Board in its discretion. Eligible participants may be awarded
stock pursuant to a stock bonus agreement in consideration of past services
actually rendered to the Company or for its benefit.
 
     Repurchase. Shares of Common Stock sold or awarded under the 1996 Plan may,
but need not, be subject to a repurchase option in favor of the Company in
accordance with a vesting schedule determined by the Board. In the event a
person ceases to be an employee of or ceases to serve as a director of or
consultant to the Company or an affiliate of the Company, the Company may
repurchase or otherwise reacquire any or all of the shares of the Common Stock
held by that person that have not vested as of the date of termination under the
terms of the stock bonus or restricted stock purchase agreement between the
Company and such person.
 
ADJUSTMENT PROVISIONS
 
     If there is any change in the stock subject to the 1996 Plan or subject to
any option granted under the 1996 Plan (through merger, consolidation,
reorganization, recapitalization, stock dividend, dividend in property other
than cash, stock split, liquidating dividend, combination of shares, exchange of
shares, change in corporate structure or otherwise), the 1996 Plan and Stock
Awards outstanding thereunder will be appropriately adjusted as to the class and
the maximum number of shares subject to the 1996 Plan, the maximum number of
shares which may be granted to any person during a calendar year, and the class,
number of shares and price per share of stock subject to such outstanding Stock
Awards.
 
EFFECT OF CERTAIN CORPORATE EVENTS
 
     The 1996 Plan provides that, in the event of a dissolution or liquidation
of the Company, specified type of merger or other corporate reorganization, to
the extent permitted by law, any surviving corporation will be required to
either assume Stock Awards outstanding under the 1996 Plan or substitute similar
Stock Awards for those outstanding under such plan, or such outstanding Stock
Awards will continue in full force and effect. If any surviving corporation
declines to assume or continue Stock Awards outstanding under the 1996 Plan, or
to substitute similar Stock Awards, then the time during which such Stock Awards
may be exercised will be accelerated, the vesting of such Stock Awards will be
accelerated if so determined by the Board, and the Stock Awards terminated if
not exercised during such time.
 
DURATION, AMENDMENT AND TERMINATION
 
     The Board may suspend or terminate the 1996 Plan without stockholder
approval or ratification at any time or from time to time. Unless sooner
terminated, the 1996 Plan will terminate on December 4, 2006.
 
     The Board may also amend the 1996 Plan at any time or from time to time.
However, no amendment will be effective unless approved by the stockholders of
the Company within twelve months before or after its adoption by the Board if
the amendment would: (a) modify the requirements as to eligibility for
participation (to the extent such modification requires stockholder approval in
order for the 1996 Plan to satisfy Section 422 of the Code, if applicable; Rule
16b-3 ("Rule 16b-3") of the Securities Exchange Act of 1934, as amended (the
"Exchange Act"); or any Nasdaq Stock Market(R) or other securities exchange
listing requirements; (b) increase the number of shares reserved for issuance
upon exercise of options; or (c) change any other provision of the Plan in any
other way if such modification requires stockholder approval in order to comply
with Rule 16b-3 or satisfy the requirements of Section 422 of the Code. The
Board may submit any other amendment to the 1996 Plan for stockholder approval,
including, but not limited to, amendments intended to satisfy the requirements
of Section 162(m) of the Code regarding the exclusion of performance-based
compensation from the limitation on the deductibility of compensation paid to
certain employees.
 
                                        7
<PAGE>   10
 
RESTRICTIONS ON TRANSFER
 
     Under the 1996 Plan, unless otherwise provided in the option agreement for
a non-statutory stock option, an option may not be transferred by the optionee
other than by will or by the laws of descent and distribution and during the
lifetime of the optionee, may be exercised only by the optionee except on such
terms as may be provided in the option agreement. In any case, an optionee may
designate in writing a third party who may exercise the option in the event of
the optionee's death. Rights under a stock bonus or restricted stock purchase
agreement are transferable only by will, by the laws of descent and distribution
or pursuant to a domestic relations order. Shares subject to repurchase by the
Company under an early exercise stock purchase agreement may be subject to
additional restrictions on transfer which the Board deems appropriate.
 
FEDERAL INCOME TAX INFORMATION
 
     The following is only a summary of the effect of federal income taxation
upon the optionee and the Company with respect to the grant and exercise of
options under the 1996 Plan, does not purport to be complete and does not
discuss the income tax laws of any state or foreign country in which an optionee
may reside.
 
     Incentive Stock Options. Incentive stock options under the 1996 Plan are
intended to be eligible for the favorable federal income tax treatment accorded
"incentive stock options" under the Code.
 
     There generally are no federal income tax consequences to the optionee or
the Company by reason of the grant or exercise of an incentive stock option.
However, the exercise of an incentive stock option may increase the optionee's
alternative minimum tax liability, if any.
 
     If an optionee holds stock acquired through exercise of an incentive stock
option for at least two years from the date on which the option is granted and
at least one year from the date on which the shares are transferred to the
optionee upon exercise of the option, any gain or loss on a disposition of such
stock will be capital gain or loss (the character of which will be determined by
the length of time the stock was held). Generally, if the optionee disposes of
the stock before the expiration of either of these holding periods (a
"disqualifying disposition"), at the time of disposition, the optionee will
realize taxable ordinary income equal to the lesser of (a) the excess of the
stock's fair market value on the date of exercise over the exercise price, or
(b) the optionee's actual gain, if any, on the purchase and sale. The optionee's
additional gain, or any loss, upon the disqualifying disposition will be a
capital gain or loss. Long-term capital gains currently are generally subject to
lower tax rates than ordinary income. The maximum capital gains rate for federal
income tax purposes is currently 20% while the maximum ordinary income rate is
effectively 39.6% at the present time. Slightly different rules may apply to
optionees who acquire stock subject to certain repurchase options or who are
subject to Section 16(b) of the Exchange Act.
 
     To the extent the optionee recognized ordinary income by reason of a
disqualifying disposition, the Company will generally be entitled (subject to
the requirement of reasonableness, the provisions of Section 162(m) of the Code
and the satisfaction of a tax reporting obligation) to a corresponding business
expense deduction in the tax year in which the disqualifying disposition occurs.
 
     Nonstatutory Stock Options. Nonstatutory stock options granted under the
1996 Plan generally have the following federal income tax consequences:
 
     There are no tax consequences to the optionee or the Company by reason of
the grant of a nonstatutory stock option. Upon exercise of a nonstatutory stock
option, the optionee normally will recognized taxable ordinary income equal to
the excess of the stock's fair market value on the date of exercise over the
option exercise price. Generally, with respect to employees, the Company is
required to withhold from regular wages or supplemental wage payments an amount
based on the ordinary income recognized. Subject to the requirement of
reasonableness, the provisions of Section 162(m) of the Code and the
satisfaction of a tax reporting obligation, the Company will generally be
entitled to a business expense deduction equal to the taxable ordinary income
realized by the optionee. Upon disposition of the stock, the optionee will
recognize a capital gain or loss equal to the difference between the selling
price and the sum of the amount paid for such stock plus any amount recognized
as ordinary income upon exercise of the option. The character of such
                                        8
<PAGE>   11
 
capital gain or loss will be determined by the length of time the stock was
held. Slightly different rules may apply to optionees who acquire stock subject
to certain repurchase options or who are subject to Section 16(b) of the
Exchange Act.
 
     Restricted Stock and Stock Bonuses. Restricted stock and stock bonuses that
may be granted under the 1996 Plan have the following federal income tax
consequences at this time:
 
     Upon acquisition of stock under a restricted stock or stock bonus award,
the recipient normally will recognize taxable ordinary income equal to the
excess of the stock's fair market value over the purchase price, if any.
However, to the extent the stock is subject to certain types of vesting
restrictions, the taxable event will be delayed until the vesting restrictions
lapse unless the recipient elects to be taxed on receipt of the stock.
Generally, with respect to employees, the Company is required to withhold from
regular wages or supplemental wage payments an amount based on the ordinary
income recognized. Subject to the requirement of reasonableness, Section 162(m)
of the Code and the satisfaction of a tax reporting obligation, the Company will
generally be entitled to a business expense deduction equal to the taxable
ordinary income realized by the recipient. Upon disposition of the stock, the
recipient will recognize a capital gain or loss equal to the difference between
the selling price and the sum of the amount paid for such stock, if any, plus
any amount recognized as ordinary income upon acquisition (or vesting) of the
stock. Such capital gain or loss will be long-term or short-term depending on
the length of time the stock was held from the date ordinary income was
measured. Slightly different rules may apply to persons who acquire stock
subject to forfeiture under Section 16(b) of the Exchange Act.
 
     Potential Limitation on Company Deductions. As part of the Omnibus Budget
Reconciliation Act of 1993, the U.S. Congress amended the Code to add Section
162(m), which denies a deduction to any publicly held corporation for
compensation paid to certain employees in a taxable year to the extent that
compensation exceeds $1,000,000 for a covered employee. It is possible that
compensation attributable to Stock Awards, when combined with all other types of
compensation received by a covered employee from the Company, may cause this
limitation to be exceeded in any particular year.
 
     Certain kinds of compensation, including qualified "performance-based
compensation," are disregarded for purposes of the deduction limitation.
Treasury regulations issued under Section 162(m) of the Code provide that
compensation attributable to stock options will qualify as performance-based
compensation, if: (i) the Stock Award plan contains a per-employee limitation on
the number of shares for which stock options may be granted during a specified
period; (ii) the per-employee limitation is approved by the stockholders; (iii)
the stock option is granted by a compensation committee comprised solely of two
or more "outside directors"; and (iv) the exercise price of the stock option is
no less than the fair market value of the stock on the date of grant. Restricted
stock and stock bonuses qualify as performance-based compensation under these
Treasury regulations only if: (i) the award is granted by a compensation
committee comprised solely of two or more "outside directors"; (ii) the award is
granted (or exercisable) only upon the achievement of an objective performance
goal established in writing by the compensation committee while the outcome is
substantially uncertain; (iii) the compensation committee certifies in writing
prior to the granting (or exercisability) of the award that the performance goal
has been satisfied; and (iv) prior to the granting (or exercisability) of the
award, stockholders have approved the material terms of the award (including the
class of employees eligible for such award, the business criteria on which the
performance goal is based, and the maximum amount (or formula used to calculate
the amount) payable upon attainment of the performance goal). Stock Awards
granted under the 1996 Plan, as amended, are intended to qualify as
performance-based compensation pursuant to Section 162(m). See "Eligibility"
above.
 
                                   PROPOSAL 3
 
               RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS
 
     The Board of Directors has selected and approved Ernst & Young LLP as the
Company's independent auditors for the fiscal year ending December 31, 1999 and
has further directed that management submit the selection of independent
auditors for ratification by the stockholders at the Annual Meeting. Ernst &
Young
 
                                        9
<PAGE>   12
 
LLP has audited the Company's financial statements since its inception in 1995.
Representatives of Ernst & Young LLP are expected to be present at the Annual
Meeting, will have an opportunity to make a statement if they so desire and will
be available to respond to appropriate questions.
 
     Stockholder ratification of the selection of Ernst & Young LLP as the
Company's independent auditors is not required by the Company's By-laws or
otherwise. However, the Board is submitting the selection of Ernst & Young LLP
to the stockholders for ratification as a matter of good corporate practice. If
the stockholders fail to ratify the selection, the Audit Committee and the Board
will reconsider whether or not to retain that firm. Even if the selection is
ratified, the Audit Committee and the Board in their discretion may direct the
appointment of different independent auditors at any time during the year if
they determine that such a change would be in the best interests of the Company
and its stockholders.
 
     The affirmative vote of the holders of a majority of the shares present in
person or represented by proxy and entitled to vote at the Annual Meeting will
be required to ratify the selection of Ernst & Young LLP. Abstentions will be
counted toward the tabulation of votes cast on proposals presented to the
stockholders and will have the same effect as negative votes. Broker non-votes
are counted towards a quorum, but are not counted for any purpose in determining
whether this matter has been approved.
 
                       THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 3
 
         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
     The following table sets forth certain information regarding the beneficial
ownership of the Company's Common Stock as of December 31, 1998 by: (i) each
nominee for director; (ii) each of the executive officers named in the Summary
Compensation Table; (iii) all executive officers and directors of the Company as
a group; and (iv) all those known by the Company to be beneficial owners of more
than five percent of its Common Stock. Except as otherwise provided below, the
address of each person listed is c/o the Company, 600 Gateway Boulevard, South
San Francisco, California 94080.
 
<TABLE>
<CAPTION>
                                                               BENEFICIAL OWNERSHIP(1)
                                                              --------------------------
                                                              NUMBER OF    PERCENTAGE OF
                      BENEFICIAL OWNER                         SHARES          TOTAL
                      ----------------                        ---------    -------------
<S>                                                           <C>          <C>
Entities affiliated with Putnam Investments, Inc(2).........  2,249,700        13.5%
  One Post Office Square
  Boston, MA 02109
Robert Momsen(3)............................................  1,816,144        10.9
Entities Affiliated with InterWest Partners(3)..............  1,811,144        10.8
  3000 Sand Hill Road
  Building 3, Suite 255
  Menlo Park, CA 94025
Arnold Oronsky, Ph.D.(4)....................................  1,799,825        10.8
Sue Van(5)..................................................    809,682         4.8
Joseph R. Coulter, III(6)...................................    492,373         2.9
Michael F. Bigham(7)........................................    414,319         2.5
Brian G. Atwood(8)..........................................    163,024       *
Dan Shochat, Ph.D.(9).......................................     91,722       *
William G. Harris(10).......................................     59,508       *
Donald L. Lucas(11).........................................     54,037       *
Dwayne M. Elwood(12)........................................     32,433       *
George J. Sella, Jr.(13)....................................     10,000       *
All executive officers and directors as a group (11
  persons)(14)..............................................  3,943,242        23.6
</TABLE>
 
                                       10
<PAGE>   13
 
- ---------------
  *  Represents beneficial ownership of less than 1% of the outstanding shares
     of the Company's Common Stock.
 
 (1) Beneficial ownership is determined in accordance with the rules of the
     Securities and Exchange Commission and generally includes voting or
     investment power with respect to securities. Except as indicated by
     footnote, and subject to community property laws where applicable, the
     Company believes, based on information furnished by such persons, that the
     persons named in the table above have sole voting and investment power with
     respect to all shares of Common Stock shown as beneficially owned by them.
     Percentage of beneficial ownership is based on 16,704,103 shares of Common
     Stock outstanding as of December 31, 1998.
 
 (2) Based solely on information obtained from a filing made on Schedule 13G
     with the SEC.
 
 (3) Includes 1,799,825 shares held by InterWest Partners V, L.P. and 11,319
     shares held by InterWest Investors V. Mr. Momsen, a director of the
     Company, is a general partner of InterWest Management Partners V, L.P.
     which is the general partner of InterWest Partners V, L.P. Mr. Momsen is a
     general partner of InterWest Investors V. Mr. Momsen disclaims beneficial
     ownership of the shares held by InterWest Partners V, L.P. and InterWest
     Investors V except to the extent of his respective pecuniary interest
     therein. Also includes 5,000 shares of Common Stock subject to options
     exercisable within sixty days of December 31, 1998.
 
 (4) Includes 1,799,825 shares held by InterWest Partners V, L.P. Dr. Oronsky, a
     director of the Company, is a general partner of InterWest Management
     Partners V, L.P. which is the general partner of InterWest Partners V, L.P.
     Dr. Oronsky disclaims beneficial ownership of the shares held by InterWest
     Partners V, L.P. except to the extent of his pecuniary interest therein.
 
 (5) Includes 753,907 shares held by the Wallace H. Coulter Charitable Remainder
     Unitrust, 18,691 shares held by the Wallace H. Coulter Trust, 14,871 shares
     held by the Sue Van Revocable Trust and 2,500 shares of Common Stock
     subject to options exercisable within sixty days of December 31, 1998. Ms.
     Van, a director of the Company, is trustee of the Wallace H. Coulter
     Charitable Remainder Unitrust and Wallace H. Coulter Trust. Ms. Van
     disclaims beneficial ownership of the shares held in the Wallace H. Coulter
     Charitable Remainder Unitrust and Wallace H. Coulter Trust to the extent of
     her pecuniary interest therein.
 
 (6) Includes 344,856 shares held by the Joseph R. Coulter, Jr. Trust and
     137,333 shares held by JRC Investment L.P. Mr. Coulter, a director of the
     Company, is co-trustee of the Joseph R. Coulter, Jr. Trust and general
     partner of JRC Investment L.P. Also includes 3,842 shares held by Mr.
     Coulter's wife, Susan Sekman Coulter and 2,500 shares of Common Stock
     subject to options exercisable within sixty days of December 31, 1998. Mr.
     Coulter disclaims beneficial ownership of the shares held by the Joseph R.
     Coulter, Jr. Trust, JRC Investment L.P. and Susan Sekman Coulter, except to
     the extent of his pecuniary interest therein.
 
 (7) Includes 150,000 shares that were issued pursuant to a restricted stock
     purchase agreement. 133,334 of such shares are subject to repurchase by the
     Company within 60 days of December 31, 1998. Also includes 227,961 shares
     held by The Michael F. Bigham Trust and 34,353 shares of Common Stock
     subject to options exercisable with sixty days of December 31, 1998. Mr.
     Bigham disclaims beneficial ownership of the shares held by the trust
     except to the extent of his pecuniary interest therein.
 
 (8) Includes 145,981 shares held by Brentwood Associates VII, L.P. and 5,000
     shares of Common Stock subject to options exercisable within sixty days of
     December 31, 1998. Mr. Atwood, a director of the Company, is a venture
     partner of Brentwood VII Ventures, L.P., which is the general partner of
     Brentwood Associates VII, L.P. Mr. Atwood disclaims beneficial ownership of
     the shares held by Brentwood Associates VII, L.P., except to the extent of
     his pecuniary interest therein.
 
 (9) Includes 65,823 shares of Common Stock subject to options exercisable
     within 60 days of December 31, 1998.
 
(10) Includes 55,459 shares of Common Stock subject to options exercisable
     within sixty days of December 31, 1998.
 
                                       11
<PAGE>   14
 
(11) Includes 41,485 shares held by the Donald L. Lucas & Lygia S. Lucas Trust.
     Donald L. Lucas, a director of the Company, is trustee of the Donald L.
     Lucas & Lygia S. Lucas Trust. Also includes 1,479 shares held by The Donald
     L. Lucas Profit Sharing Plan, 1,479 shares held by Sand Hill Financial
     Company and 5,000 shares of Common Stock subject to options exercisable
     within sixty days of December 31, 1998. Mr. Lucas disclaims beneficial
     ownership of the shares held by the Donald L. Lucas & Lygia S. Lucas Trust,
     the Donald L. Lucas Profit Sharing Plan and Sand Hill Financial Company,
     except to the extent of his pecuniary interest therein.
 
(12) Includes 29,229 shares of Common Stock subject to options exercisable
     within sixty days of December 31, 1998.
 
(13) All 10,000 shares of Common Stock are subject to options exercisable within
     sixty days of December 31, 1998.
 
(14) Includes 3,728,378 shares held by directors and executive officers of the
     Company, and entities and persons affiliated therewith. Also includes
     214,864 shares of Common Stock subject to options exercisable within sixty
     days of December 31, 1998. See Notes (2) through (13) above.
 
                             EXECUTIVE COMPENSATION
 
COMPENSATION OF DIRECTORS
 
     Directors currently do not receive any cash compensation from the Company
for their services as members of the Board of Directors, although they are
eligible for reimbursement for certain expenses incurred in connection with
attendance at Board and Committee meetings in accordance with Company policy. In
February 1998, Mr. Sella was granted options to purchase 5,000 shares of the
Company's Common Stock which were issued under the 1996 Equity Incentive Plan.
The fair market value of such Common Stock on the date of grant was $22.75 per
share (based on the closing sales price reported on the Nasdaq Stock Market for
the date of grant). Options granted to directors under the 1996 Equity Incentive
Plan are intended not to qualify as incentive stock options under the Code. As
of March 12, 1999, none of the options granted to Mr. Sella had been exercised.
 
                       COMPENSATION OF EXECUTIVE OFFICERS
 
     Summary Compensation Table. The following table shows for the fiscal years
ended December 31, 1998, 1997 and 1996, compensation awarded or paid to, or
earned by, the Company's Chief Executive Officer and its two most highly
compensated executive officers at December 31, 1998 (the "Named Executive
Officers").
 
SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                                         LONG-TERM
                                                                                        COMPENSATION
                                                                                        ------------
                                            ANNUAL COMPENSATION         OTHER ANNUAL     SECURITIES
                                       -----------------------------    COMPENSATION     UNDERLYING
     NAME AND PRINCIPAL POSITION       YEAR    SALARY($)    BONUS($)       ($)(1)        OPTIONS(#)
     ---------------------------       ----    ---------    --------    ------------    ------------
<S>                                    <C>     <C>          <C>         <C>             <C>
Michael F. Bigham(2).................  1998     350,000      75,000       $ 70,000(2)      80,000
  President and Chief Executive        1997     320,000     100,000        240,869(2)     100,000
  Officer                              1996     150,000      50,000         57,000(2)           0
Dan Shochat, Ph.D. ..................  1998     201,667      30,000              0         35,000
  Senior Vice President and Chief      1997     182,754      38,000              0         30,000
  Scientific Officer                   1996     160,008       8,750              0         41,666
William G. Harris(3).................  1998     190,000      30,000              0         35,000
  Vice President and Chief             1997     170,000      30,000              0         27,500
  Financial Officer                    1996      57,656       5,000              0         83,332
</TABLE>
 
                                       12
<PAGE>   15
 
- ---------------
(1) As permitted by rules promulgated by the SEC, no amounts are shown for
    "perquisites," where such amounts for each named executive officer do not
    exceed the lesser of 10% of the sum of such executive's bonus plus salary or
    $50,000.
 
(2) Mr. Bigham joined the Company as its President and Chief Executive Officer
    in July 1996. During June 1996, Mr. Bigham provided consulting services to
    the Company and received $57,000 in compensation for those services. The
    1997 amount represents $157,500 related to a stock bonus grant contingent
    upon certain performance based conditions and $83,369 related to certain
    forgiveness of a home loan. The 1998 amount represents $70,000 related to
    certain forgiveness of a home loan.
 
(3) Mr. Harris joined the Company as its Vice President and Chief Financial
    Officer in July 1996. On an annualized basis, his 1996 salary was $130,000.
 
OPTION GRANTS IN LAST FISCAL YEAR
 
     The Company grants options to its executive officers pursuant to its 1996
Equity Incentive Plan. As of March 12, 1999, 2,154,874 shares were outstanding
under the 1996 Equity Incentive Plan and 597,084 shares remained available for
grant thereunder.
 
     The following table sets forth, for the fiscal year ended December 31,
1998, certain information regarding options granted to, exercised by, and held
at year-end by the Named Executive Officers:
 
<TABLE>
<CAPTION>
                                                INDIVIDUAL GRANTS                        POTENTIAL REALIZABLE
                            ----------------------------------------------------------     VALUE AT ASSUMED
                              NUMBER OF                                                  ANNUAL RATES OF STOCK
                             SECURITIES       PERCENTAGE OF                               PRICE APPRECIATION
                             UNDERLYING       TOTAL OPTIONS     EXERCISE                  FOR OPTION TERM(4)
                               OPTIONS         GRANTED IN         PRICE     EXPIRATION   ---------------------
           NAME             GRANTED(#)(1)    FISCAL 1998(2)     ($/SH)(3)      DATE        5%($)      10%($)
           ----             -------------   -----------------   ---------   ----------   ---------   ---------
<S>                         <C>             <C>                 <C>         <C>          <C>         <C>
Michael F. Bigham.........     80,000             7.2%           24.125      7/27/08     1,123,766   3,075,923
Dan Shochat, Ph.D.........     35,000             3.1%           24.125      7/27/08       531,023   1,345,716
William G. Harris.........     35,000             3.1%           24.125      7/27/08       531,023   1,345,716
</TABLE>
 
- ---------------
(1) Options granted in 1998 generally vest over four years, with 1/48 vesting in
    each month, with full vesting occurring on the fourth anniversary date of
    the grant.
 
(2) Based on an aggregate of 1,117,800 options granted to employees in 1998,
    including the Named Executive Officers.
 
(3) The exercise price per share of each option was equal to the fair market
    value of the common stock on the date of grant, as determined by the board
    of directors.
 
(4) The potential realizable value is calculated by assuming that the stock
    price on the date of grant as determined by the board of directors
    appreciates at the indicated annual rate compounded annually for the entire
    term of the option (ten years) and the option is exercised and sold on the
    last day of its term for the appreciated stock price. The 5% and 10% assumed
    rates of appreciation are mandated by the rules of the Securities and
    Exchange Commission and do not represent the company's estimate or
    projection of the future common stock price.
 
                                       13
<PAGE>   16
 
AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR-END OPTION
VALUES
 
     The following table sets forth for each of the Named Executive Officers the
shares acquired and the value realized on the exercise of stock options during
the fiscal year ended December 31, 1998 and the number and value of securities
underlying unexercised options held by the Named Executive Officers at December
31, 1998:
 
<TABLE>
<CAPTION>
                                                             NUMBER OF SECURITIES
                                                                  UNDERLYING               VALUE OF UNEXERCISED
                                                            UNEXERCISED OPTIONS AT        IN-THE-MONEY OPTIONS AT
                                   SHARES       VALUE        DECEMBER 31, 1998(#)         DECEMBER 31, 1998($)(1)
                                 ACQUIRED ON   REALIZED   ---------------------------   ---------------------------
             NAME                EXERCISE(#)     ($)      EXERCISABLE   UNEXERCISABLE   EXERCISABLE   UNEXERCISABLE
             ----                -----------   --------   -----------   -------------   -----------   -------------
<S>                              <C>           <C>        <C>           <C>             <C>           <C>
Michael F. Bigham..............      --          --         29,895         150,105         587,344      1,842,031
Dan Shochat, Ph.D..............      --          --         60,519          82,605       1,667,201      1,456,208
William G. Harris..............      --          --         50,952          94,880       1,372,801      1,820,466
</TABLE>
 
- ---------------
(1) Based on the fair market value of $30.00 per share on December 31, 1998, as
    determined by the closing sales price reported on the Nasdaq Stock Market
    minus the exercise price multiplied by the number of shares underlying the
    option.
 
EMPLOYMENT AGREEMENTS
 
     In March 1996, Michael F. Bigham, Chief Executive Officer and President of
the Company, purchased 400,000 shares of Common Stock at $0.45, the fair market
value of such shares, and purchased the shares by delivering a promissory note
in the amount of $180,000. The Company has a right to repurchase these shares in
the event Mr. Bigham's employment is terminated. Such repurchase right lapses
over a four-year period which may be accelerated if Mr. Bigham's employment is
involuntarily terminated for a reason other than gross misconduct. If the
Company terminates Mr. Bigham's employment for any reason other than gross
misconduct, the Company will continue to pay his salary and provide full
benefits for one year after such termination and the Company's stock repurchase
rights will continue to expire during such period. In the event of a change in
control of the Company, Mr. Bigham will receive severance equal to at least two
years salary plus a 30% bonus and full benefits for two years. In addition, all
repurchase right expirations will be accelerated in full. In July 1996, the
Company entered into an agreement with Mr. Bigham pursuant to which he repaid an
outstanding loan to the Company in the amount of $180,000 and obtained from the
Company a home loan in the amount of $280,000, which new loan is secured by a
second deed of trust on his principal residence. This loan will be forgiven
semiannually at the rate of 12.5% per semiannual period so long as Mr. Bigham
remains employed by the Company. At December 31, 1998, $140,000 remained
outstanding on such loan from the Company. If Mr. Bigham's employment is
terminated, interest shall commence and begin to accrue at the prime rate plus
two percentage points and will become due and payable within 60 days of his
termination. If Mr. Bigham's employment is terminated for any reason other than
gross misconduct or death, the principal of such loan shall become due upon the
earlier of Mr. Bigham securing other employment or the date 60 days from the
date of his termination. In the event of a change in control of the Company, the
remaining balance on the home loan will be forgiven.
 
REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS ON EXECUTIVE
COMPENSATION(1)
 
     The Compensation Committee of the Board of Directors (the "Committee") is
composed of four non-employee directors: Arnold Oronsky, Donald Lucas, Robert
Momsen and Sue Van. The Committee is responsible for recommending and
administering the Company's policies governing employee compensation and for
administering the Company's employee benefit plans, including its stock plans.
The Committee evaluates the performance of management, recommends compensation
policies and levels, and makes
 
- ---------------
 
1 The material in this report is not "soliciting material," is not deemed filed
  with the SEC and is not to be incorporated by reference in any filing of the
  Company under the Securities Act of 1933, as amended (the "1993 Act"), whether
  made before or after the date hereof and irrespective of any general
  incorporation language in any filing.
                                       14
<PAGE>   17
 
recommendations concerning salaries and incentive compensation. The full Board
of Directors reviews the Committee's recommendations regarding the compensation
of the executive officers of the Company.
 
     The Company's executive compensation program is designed to attract and
retain executives capable of leading the Company to meet its business objectives
and to motivate them to enhance long-term stockholder value. The key elements of
the program are competitive pay and equity incentives, with an emphasis on
equity incentives. Annual compensation for the Company's executive officers
consists of base salary, bonuses and stock option grants.
 
     The Committee makes compensation determinations based upon a subjective
assessment of a variety of factors, both personal and corporate, in evaluating
the performance of the Company's executive officers and making compensation
decisions. These factors include, in order of importance, the progress of the
Company toward its long term objectives, the individual contributions of each
officer to the Company, and the compensation paid by selected biotechnology
companies to individuals in comparable positions. The Committee's weighing of
these factors in determining the compensation of an individual executive officer
may vary, and the Committee does not apply specific guidelines.
 
     At this point in the Company's evolution, the measures the Committee looks
to in evaluating the Company's progress are the timing and results of the
Company's clinical trials of its initial product, success in the preclinical and
clinical development of additional products, the effectiveness with which
management identifies and secures strategic opportunities to fully exploit its
current intellectual property assets and to obtain access to additional such
assets, the ability of management to secure financing for the Company's
operations, the efficient utilization of corporate resources, and the hiring and
retention of subordinate officers and other key employees best capable of
accomplishing the foregoing.
 
     In July 1998, the Committee met to consider the compensation of the
Company's executive officers for the next twelve-month period. The Committee
considered a variety of factors, both individual and corporate, in evaluating
the performance of the Company's executive officers. The Committee reviewed an
analysis of compensation done by an independent compensation consulting group
with regard to compensation, including equity-based incentives, at a select
group of companies. In addition, the Committee reviewed the results of other
independent surveys that provided information regarding management compensation
for approximately 200 companies in the biopharmaceutical industry, categorized
by geographic area and management position. The surveys include a broader group
of companies than those companies included in the NASDAQ Pharmaceutical Index
used in the performance measurement comparison graph included in this proxy
statement. The Committee also reviewed other publicly available information,
gathered informally, pertaining to compensation of executive officers in the
biopharmaceutical industry. Generally, the Committee targeted compensation to
result in base salaries that were at the high-mid-range of competitive salary
levels.
 
     As a result of the review, the committee approved an increase in Mr.
Bigham's salary of approximately 15% for the twelve-month period commencing July
1998, reflecting in part the committee's assessment of Mr. Bigham's
contributions to the progress of the Company during his tenure as President and
Chief Executive Officer, as well as competitive considerations. In particular,
the Committee took into account progress made in the continued development of
Bexxar(TM), evaluating and negotiating with potential marketing partners as well
as Mr. Bigham's achievements in recruiting individuals to serve in key positions
in the Company and in financing the Company. Similar factors accounted for the
increases in the base salaries of the other executive officers for the same
period.
 
     During 1998, the Board provided stock options to the executive officers of
the Company pursuant to the 1996 Equity Incentive Plan. The exercise price of
the option grants were equal to the fair market value of the Company's Common
Stock on the date of grant. The executive officers received stock options for a
total of 150,000 shares during 1998.
 
                                       15
<PAGE>   18
 
     Section 162(m) of the Code limits the Company to a deduction for federal
income tax purposes of not more than $1 million of compensation paid to certain
executive officers in a taxable year. Compensation above $1 million may be
deducted if it is "performance-based compensation" within the meaning of the
Code. The Board of Directors has not yet established a policy for determining
which forms of incentive compensation awarded to executive officers shall be
designed to qualify as performance-based compensation.
 
                                          COMPENSATION COMMITTEE OF THE COMPANY
                                          Arnold Oronsky
                                          Donald L. Lucas
                                          Robert Momsen
                                          Sue Van
 
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
     Prior to the formation of the Compensation Committee in October 1996, the
Board of Directors made all determinations with respect to executive officer
compensation. Of the current and former directors who participated in
deliberations concerning executive officer compensation, either prior to the
formation of the Compensation Committee or in their capacity as a member of the
Compensation Committee, Dr. Oronsky served as acting President and Chief
Executive Officer of the Company from February 1995 to June 1996, Ms. Bobbie
Wallace served as Vice President, Operations of the Company from February 1995
to March 1997 and Mr. Bigham has served as President and Chief Executive Officer
of the Company since July 1996. Each of the Company's directors, except for Mr.
Sella, has purchased securities of the Company individually or through an
affiliated entity. See "Certain Transactions" and "Security Ownership of Certain
Beneficial Owners and Management."
 
                                       16
<PAGE>   19
 
PERFORMANCE MEASUREMENT COMPARISON
 
     The following graph compares total stockholder returns of the Company since
its initial public offering of Common Stock on January 28, 1997 to two indices:
the NASDAQ CRSP Total Return Index for the NASDAQ Stock Market (U.S. companies)
(the "NASDAQ-US") and the NASDAQ Pharmaceutical Index (the
"NASDAQ-Pharmaceutical"). The total return for the Company's stock and for each
index assumes the reinvestment of dividends, although dividends have never been
declared on the Company's stock, and is based on the returns of the component
companies weighted according to their capitalizations as of the end of each
monthly period. The NASDAQ-US tracks the aggregate price performance of equity
securities of U.S. companies traded on the NASDAQ National Market (the "National
Market"). The NASDAQ-Pharmaceutical tracks the aggregate price performance of
equity securities of pharmaceutical companies traded on the National Market. The
Company's Common Stock is traded on the National Market and is a component of
both the NASDAQ-US and the NASDAQ-Pharmaceutical.
 
           COMPARISON OF CUMULATIVE TOTAL RETURN ON INVESTMENT SINCE
          THE COMPANY'S INITIAL PUBLIC OFFERING ON JANUARY 28, 1997(2)
                                      LOGO
 
- ---------------
(2) Shows the cumulative total return on investment assuming an investment of
    $100 in each of the Company, the NASDAQ-US and the NASDAQ-Pharmaceutical on
    January 28, 1997. The cumulative total return on the Company's stock has
    been computed based on an initial price of $12.00 per share, the price at
    which the Company's shares were sold in its initial public offering on
    January 28, 1997.
                                       17
<PAGE>   20
 
                              CERTAIN TRANSACTIONS
 
     In July 1998, the Company granted Mr. Bigham, Mr. Harris and Dr. Shochat,
officers of the Company, options to purchase 80,000, 35,000 and 35,000 shares of
common stock, respectively. Such options have an exercise price of $24.125 per
share and vest over a four-year period.
 
     In September 1998, the Company entered into an agreement with Mr. Harris
pursuant to which he obtained from the Company a home loan in the amount of
$100,000, which is secured by a second deed of trust on his principal residence.
Ten percent of this loan will be forgiven annually beginning in the sixth year
of the loan period so long as Mr. Harris remains employed by the Company. If Mr.
Harris' employment is terminated, interest shall commence and begin to accrue at
the prime rate plus two percentage points and such interest and the outstanding
principal will become due and payable within 90 days of his termination.
 
     As permitted by the Delaware General Corporation Law (the "Delaware Law"),
the Company's Certificate of Incorporation provides that no director of the
Company will be personally liable to the Company or its stockholders for
monetary damages for breach of fiduciary duty as a director, except (i) for any
breach of the directors' duty of loyalty to the Company or its stockholders,
(ii) for acts or omissions not in good faith or involving intentional misconduct
or a knowing violation of law, (iii) unlawful payments of dividends or unlawful
stock repurchases or redemptions, or (iv) for any transaction from which the
director derives any improper personal benefit. In addition, the Company's
Bylaws provide that the Company shall indemnify any director and may indemnify
any officer, to the fullest extent permitted by the Delaware Law, who was or is
a party or is threatened to be made a party to any action or proceeding by
reason of his or her services to the Company.
 
     The Company has entered into indemnity agreements with each of its
directors and executive which provide, among other things, that the Company will
indemnify each of them against expenses and losses incurred for claims brought
against them by reason of their being a director or executive officer of the
Company. In addition, the Company has purchased directors' and officers'
liability insurance. There is no pending litigation or proceeding involving a
director or officer of the Company as to which indemnification is being sought,
nor is the Company aware of any pending or threatened litigation that may result
in claims for indemnification by any director or executive officer.
 
            SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
 
     Section 16(a) of the Exchange Act of 1934 requires the Company's directors
and executive officers, and persons who beneficially own more than ten percent
of a registered class of the Company's equity securities, to file with the SEC
initial reports of ownership and reports of changes in ownership of Common Stock
and other equity securities of the Company. Officers, directors and greater than
ten percent stockholders are required by SEC regulation to furnish the Company
with copies of all Section 16(a) forms they filed.
 
     To the Company's knowledge, based solely on a review of the copies of such
reports furnished to the Company and written representations that no other
reports were required, during the fiscal year ended December 31, 1998, all
Section 16(a) filing requirements applicable to its officers, directors and
greater than ten percent beneficial owners were complied with.
 
                                       18
<PAGE>   21
 
                                 OTHER MATTERS
 
     The Board of Directors knows of no other matter that may come before the
Annual Meeting. If any other matters are properly presented at the Annual
Meeting, it is the intention of the persons named in the accompanying proxy to
vote, or otherwise to act, in accordance with their best judgment.
 
                                          By Order of the Board of Directors
                                          /s/ James C. Kitch
                                          James C. Kitch
                                          Secretary
 
April 27, 1999
 
     A COPY OF THE COMPANY'S ANNUAL REPORT TO THE SECURITIES AND EXCHANGE
COMMISSION ON FORM 10-K FOR THE FISCAL YEAR ENDED DECEMBER 31, 1998 IS AVAILABLE
WITHOUT CHARGE UPON WRITTEN REQUEST TO: INVESTOR RELATIONS, COULTER
PHARMACEUTICAL, INC., 600 GATEWAY BOULEVARD, SOUTH SAN FRANCISCO, CALIFORNIA
94080.
 
                                       19
<PAGE>   22
                          COULTER PHARMACEUTICAL, INC.

                    PROXY SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON MAY 21, 1999

        The undersigned hereby appoints Michael F. Bigham and William G. Harris,
and each of them, as attorneys and proxies of the undersigned, with full power
of substitution, to vote all of the shares of stock of Coulter Pharmaceutical,
Inc. which the undersigned may be entitled to vote at the Annual Meeting of
Stockholders of Coulter Pharmaceutical, Inc. to be held the Hyatt Regency Hotel
(San Francisco Airport), 1333 Bayshore Highway, Burlingame, California 94010 on
May 21, 1999, at 10:00 a.m. local time, and at any and all postponements,
continuations and adjournments thereof, with all powers that the undersigned
would possess if personally present, upon and in respect of the following
matters and in accordance with the following instructions, with discretionary
authority as to any and all other matters that may properly come before the
meeting.

        UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED FOR
ALL NOMINEES LISTED IN PROPOSAL 1 AND FOR PROPOSALS 2 AND 3, AS MORE
SPECIFICALLY DESCRIBED IN THE PROXY STATEMENT. IF SPECIFIC INSTRUCTIONS ARE
INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH.

MANAGEMENT RECOMMENDS A VOTE FOR THE NOMINEES FOR DIRECTOR LISTED BELOW.

PROPOSAL 1:    To elect eight (8) directors to hold office until the next
               Annual Meeting of Stockholders and until their successors are
               elected.

[ ]   FOR all nominees listed below               [ ] WITHHOLD AUTHORITY to
      (except as marked to the contrary below)        vote for all nominees 
                                                      listed below

NOMINEES: Michael F. Bigham, Arnold L. Oronsky, Brian G. Atwood, 
          Joseph R. Coulter III, Donald L. Lucas, Robert Momsen, 
          George J. Sella, Jr., and Sue Van.

    TO WITHHOLD AUTHORITY TO VOTE FOR ANY NOMINEE(S), WRITE SUCH NOMINEE(S)'
                                 NAME(S) BELOW

                            (Continued on other side)


<PAGE>   23



                           (Continued from other side)

MANAGEMENT RECOMMENDS A VOTE FOR PROPOSAL 2.

PROPOSAL 2:    To approve the Company's 1996 Equity Incentive Plan, as amended,
               to increase the aggregate number of shares of Common Stock
               authorized for issuance under such plan by 2,000,000 shares.

               FOR                  AGAINST              ABSTAIN
               [ ]                    [ ]                  [ ]


MANAGEMENT RECOMMENDS A VOTE FOR PROPOSAL 3.

PROPOSAL 3:    To ratify selection of Ernst & Young LLP as independent
               auditors of the Company for its fiscal year ending December 31,
               1999.

               FOR                  AGAINST              ABSTAIN
               [ ]                    [ ]                  [ ]

SIGNATURE(S)__________________________ DATED______________________________, 1999

        Please sign exactly as your name appears hereon. If the stock is
registered in the names of two or more persons, each should sign. Executors,
administrators, trustees, guardians and attorneys-in-fact should add their
titles. If signer is a corporation, please give full corporate name and have a
duly authorized officer sign, stating title. If signer is a partnership, please
sign in partnership name by authorized person.

PLEASE VOTE, DATE AND PROMPTLY RETURN THIS PROXY IN THE ENCLOSED RETURN ENVELOPE
WHICH IS POSTAGE PREPAID IF MAILED IN THE UNITED STATES.



© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission