US ONCOLOGY INC
SC 13D, 1999-08-30
SPECIALTY OUTPATIENT FACILITIES, NEC
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<PAGE>

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                 SCHEDULE 13D
                                (Rule 13d-101)

            INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                 RULE 13d-2(a)

                         (Amendment No.            )*


                              Ilex Oncology, Inc.
- --------------------------------------------------------------------------------
                               (Name of Issuer)


                                 Common Stock
- --------------------------------------------------------------------------------
                        (Title of Class of Securities)


                                  451923 10 6
- --------------------------------------------------------------------------------
                                (CUSIP Number)


Phillip H. Watts, Esq., 16825 Northchase Drive, Suite 1300, Houston, TX  77060.
- --------------------------------------------------------------------------------
                (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)


                               August 18, 1999
- --------------------------------------------------------------------------------
            (Date of Event which Requires Filing of This Statement)

  If the filing person has previously filed a statement on Schedule 13G to
report the acquisition  that is the subject of this Schedule 13D, and is filing
this schedule  because  of Rule  13d-1(e),  13d-1(f)  or  13d-1(g),  check  the
following box [_].

    Note:  Schedules filed in paper format shall include a signed original
  and five copies of the schedule, including all exhibits. See Rule 13d-7(b)
  for other parties to whom copies are to be sent.

                        (Continued on following pages)

- ----------

*   The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the  Securities  Exchange
Act of 1934 or otherwise subject to the liabilities of that section of the Act
but shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).
<PAGE>

CUSIP No. 451923 10 6                  13D


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

       PRN Research, Inc. ("PRNR")

________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                (a)  [X]
                                                                (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*

     PRNR acquired the securities pursuant to a Services Agreement and
Termination Agreement, in exchange for services provided by PRNR to the Issuer,
as more fully described in this report.

________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
     PURSUANT TO ITEMS 2(d) OR 2(e)                                  [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION

     PRNR is a Texas corporation.

________________________________________________________________________________
                7    SOLE VOTING POWER

NUMBER OF          1,255,988 (all of such shares are owned by PRNR, a
                   wholly owned subsidiary of USON)
 SHARES      _________________________________________________________________
                8    SHARED VOTING POWER
BENEFICIALLY
                     0
OWNED BY
               _________________________________________________________________
 EACH           9    SOLE DISPOSITIVE POWER

REPORTING          1,255,988 (all of such shares are owned by PRNR, a wholly
                   Owned subsidiary of USON)
 PERSON      _________________________________________________________________
                10   SHARED DISPOSITIVE POWER
 WITH
                     0

________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,255,988

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                     [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     7.7%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

     CO

________________________________________________________________________________
          *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

CUSIP No. 451923 10 6                  13D


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     US Oncology, Inc. ("USON")

________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                (a)  [X]
                                                                (b)  [_]

________________________________________________________________________________
3    SEC USE ONLY



________________________________________________________________________________
4    SOURCE OF FUNDS*

     PRNR, a wholly owned subsidiary of USON, acquired the securities pursuant
to a Services Agreement and Termination Agreement in exchange for services
provided by PRNR to the Issuer, as more fully described in this report.

________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
     PURSUANT TO ITEMS 2(d) OR 2(e)                                  [_]



________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION

     USON is a Delaware corporation.

________________________________________________________________________________
                7    SOLE VOTING POWER

NUMBER OF          1,255,988 (all of such shares are owned by PRNR, a wholly
                   owned subsidiary of USON)
 SHARES      _________________________________________________________________
                8    SHARED VOTING POWER
BENEFICIALLY
                     0
OWNED BY
               _________________________________________________________________
 EACH           9    SOLE DISPOSITIVE POWER

REPORTING          1,255,988 (all of such shares are owned by PRNR, a wholly
                   Owned subsidiary of USON)
 PERSON      _________________________________________________________________
                10   SHARED DISPOSITIVE POWER
 WITH
                     0

________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

             1,255,988

________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                     [_]

________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

             7.7%

________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

             CO HC

________________________________________________________________________________
          *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

CUSIP No. 451923 10 6                   13D


________________________________________________________________________________
Item 1.  Security and Issuer.

     This Statement on Schedule 13D relates to the Common Stock, $0.01 par
value per share (the "Shares"), of Ilex Oncology, Inc., a Delaware corporation
(the "Issuer"). The principal executive offices of the Company are located
at 11550 IH-10 West Suite 300, San Antonio, Texas 78245.

________________________________________________________________________________
Item 2.  Identity and Background.

(a)  This Statement is filed by US Oncology, Inc. and PRN Research, Inc.
     (collectively, the "Reporting Persons").

(b)  The principal executive offices of the Reporting Persons are located at
     16825 Northchase Drive, Suite 1300, Houston, Texas 77060.

(c)  The Reporting Persons provide practice management, administrative and other
     services to physician groups specializing in the treatment of cancer.  PRNR
     is an indirect wholly owned subsidiary of USON focusing on research
     activities of managed groups.

Information regarding the foregoing with respect to each of the Officers and
Directors of each of the Reporting Persons is set forth on Schedule A to this
Schedule 13-D.

(d)  Neither of the Reporting Persons, nor, to the knowledge of the Reporting
     Persons, any of the individuals named on Schedule A hereto, has been
     convicted in a criminal proceeding in the past five years (excluding
     traffic violations or similar misdemeanors).

(e)  During the past five years, neither of the Reporting Persons, nor, to the
     knowledge of the Reporting Persons any of the individuals named on Schedule
     A hereto, was a party to a civil proceeding of a judicial or administrative
     body of competent jurisdiction as a result of which such person was or is
     subject to a judgment, decree or final order enjoining future violations
     of, or prohibiting or mandating activities subject to, federal or state
     securities laws of finding any violation with respect to such laws.

(f)  Each of the officers and directors of the Reporting Persons is a United
     States citizen.
________________________________________________________________________________
Item 3.  Source and Amount of Funds or Other Consideration.

    The shares of Common Stock were acquired by PRNR pursuant to the terms of
that certain Service Agreement (the "Service Agreement"), dated effective June
30, 1997, by and between PRNR and the Issuer, pursuant to which the Issuer and
PRNR provided certain services to one another relating to managing and
sponsoring oncology clinical research trials.  As described below, the Service
Agreement has been terminated.  Prior to such termination, PRNR had received a
total of 626,788 shares of common stock in July of 1997 and July of 1998
pursuant to the Service Agreement.  In addition, if the Service Agreement had
continued in effect, PRNR would have been entitled to receive 314,600 shares on
each of July 1, 1999 and July 1, 2000.  Under the terms of the Service
Agreement, PRNR would also have been entitled to receive additional shares of
Common Stock of the Issuer if certain financial thresholds relating to clinical
trials were met.  In addition, during the term of the Service Agreement, the
Issuer had agreed to cause to be nominated to the Issuer's board of directors an
individual designated by PRNR.  Currently, Joseph S. Bailes, M.D., an officer of
USON, serves in such capacity on the Issuer's board.

    PRNR and the Issuer entered into a Termination Agreement (the "Termination
Agreement"), pursuant to which the Service Agreement was terminated effective
June 30, 1999.  The Termination Agreement terminated all of PRNR's rights under
the Service Agreement, including the right to receive additional stock payments
in the future and the right to designate a nominee to the Issuer's board of
directors.  Pursuant to the Termination Agreement, the Issuer agreed to issue
to PRNR an additional 629,200 shares of its Common Stock. The Shares were
issued on August 18, 1999.

    The Issuer and PRNR also entered into a Registration Rights Agreement dated
July 7, 1997, pursuant to which the Issuer has agreed to register the shares of
its Common Stock delivered to PRNR pursuant to the Service Agreement and the
Termination Agreement, subject to the terms and conditions more fully set forth
therein.  The Registration Rights Agreement was not terminated by the
Termination Agreement.

________________________________________________________________________________
Item 4.  Purpose of Transaction.

    PRNR acquired the Common Stock reported in Item 5(c) as consideration for
its services under the Service Agreement, and in consideration of its agreement
to terminate the Service Agreement as evidenced by the Termination Agreement.
PRNR holds the shares for investment purposes only. Depending upon its
evaluation of the Issuer's prospects, and upon future developments (including,
but not limited to, market for the Shares, availability of funds, alternative
uses of funds, and money, stock market and general economic conditions), each of
the Reporting Persons may from time to time purchase the Common Stock, or
dispose of all or a portion of the Common Stock that it holds, or cease buying
or selling Common Stock. Any such additional purchases or sales of the Common
Stock may be in open market or privately-negotiated transactions or otherwise.

     Except as set forth above, neither of the Reporting Persons and, to the
knowledge of the Reporting Persons no officer or director thereof, has a plan or
proposal which relates to or would result in: (a) The acquisition by any person
of additional securities of the Issuer, or the disposition of securities of the
Issuer; (b) An extraordinary corporate transaction such as a merger,
reorganization or liquidation involving the Issuer or any of its subsidiaries;
(c) A sale or transfer of a material amount of assets of the Issuer or any of
its subsidiaries; (d) Any change in the present Board of Directors or management
of the Issuer, including any plans or proposals to change the number of or term
of Directors or to fill any existing vacancies on the Board; (e) Any material
change in the present capitalization or dividend policy of the Issuer; (f) Any
other material change in the Issuer's business or corporate structure; (g)
Changes in the Issuer's charter, by-laws, or instruments corresponding thereto
or other actions which may impede the acquisition of control of the Issuer by
any person; (h) Causing the Common Stock to cease to be authorized to be traded
on The Nasdaq Stock Market, Inc. (i) To have the Common Stock terminated from
registration under the Securities Act of 1933; or (j) Any action similar to any
of those enumerated above.

________________________________________________________________________________
Item 5.  Interest in Securities of the Issuer.

(a)  The Reporting Persons are beneficial owners of 1,255,988 shares of Common
     Stock or approximately 7.7% of the shares reported as outstanding by the
     Issuer in its Form 10-Q for the quarter June 30, 1999.  PRNR is the
     direct beneficial and record owner of all such shares. In addition, in his
     capacity as a director of the Issuer, Joseph Bailes, M.D., an executive
     officer of USON, is the holder of options to purchase 9,056 shares of
     Common Stock of the Issuer.

(b)  PRNR has the power to direct the disposition of and vote the stock held by
     it. As the ultimate corporation of PRNR, USON may be deemed to have
     beneficial ownership of the shares owned by PRNR.
(c)  Neither of the Reporting Persons, nor to the knowledge of the Reporting
     persons, any of their officers or directors have effected transactions in
     the Issuer's Common Stock during the past sixty (60) days, other than as
     described herein.
(d)  No person other than PRNR has the right to receive dividends and proceeds
     from the sale of Common Stock held by it. As PRNR's ultimate parent
     corporation, USON may be deemed to have the power to direct the receipt of
     dividends and the proceeds from the sale of the Common Stock held by PRNR.
(e)  Not Applicable.


________________________________________________________________________________
Item 6.  Contracts, Arrangements, Understandings or Relationships with Respect
         to Securities of the Issuer.

          See disclosure in Items 3 and 4.  In addition, in his capacity as a
director of the Issuer, Joseph Bailes, M.D., an executive officer of USON, is
the holder of options to purchase 9,056 shares of Common Stock of the Issuer.

________________________________________________________________________________
Item 7.  Material to be Filed as Exhibits.

          Exhibit 1.  Service Agreement effective June 30, 1997 by and between
the Issuer and PRNR (filed as Exhibit 10.4 to the Issuer's quarterly report on
Form 10-Q for the quarter ended June 30, 1997 and incorporated herein by
reference)

          Exhibit 2.  Termination Agreement effective June 30, 1999 by and
between the Issuer and PRNR (filed as Exhibit 10.3 to USON's quarterly report on
Form 10-Q for the quarter ended June 30, 1999 and incorporated herein by
reference.)

          Exhibit 3.  Registration Rights Agreement dated July 7, 1997, by and
between the Issuer and PRNR (filed as Exhibit 10.5 to the Issuer's quarterly
report on Form 10-Q for the quarter ended June 30, 1997 and incorporated herein
by reference.)

________________________________________________________________________________
<PAGE>

                                   SIGNATURE


  After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


PRN Research, Inc.


/s/ L. Fred Pounds                              Dated:  August 23, 1999
- ---------------------------------                     -------------------------
L. Fred Pounds, Treasurer and
Secretary

US Oncology, Inc.


/s/ L. Fred Pounds                              Dated:  August 23, 1999
- ---------------------------------                     -------------------------
L. Fred Pounds, Chief Financial
Officer


Attention.  Intentional  misstatements  or omissions of fact constitute  federal
criminal violations (see 18 U.S.C. 1001).
<PAGE>

                                   Schedule A
                                   ----------


Officers and Directors of PRN Research, Inc.
- --------------------------------------------

R. Dale Ross            President and Director
Lloyd K. Everson, M.D.  Vice President and Director
L. Fred Pounds          Treasurer and Secretary and Director
L. Duane Choate         Vice President and Assistant Secretary


Executive Officers of US Oncology, Inc.
- ---------------------------------------

R. Dale Ross            Chairman of the Board and Chief Executive Officer
Lloyd K. Everson, M.D.  President
L. Fred Pounds          Chief Financial Officer, Vice President of Finance and
                        Treasurer
O. Edwin French         Chief Operating Officer
Leo E. Sands            Chief Compliance Officer
David Chernow           Chief Development Officer
Joseph S. Bailes, M.D.  Executive Vice President
L. Duane Choate         Vice President of Operations

The present business address of all of the foregoing individuals is 16825
Northchase Drive, Suite 1300, Houston, Texas  77060.
<PAGE>

Directors of US Oncology, Inc.
- ------------------------------

<TABLE>
<CAPTION>
Name                                               Present Business Address                            Present Principal Occupation

<S>                                   <C>                                                   <C>
R. Dale Ross                          16825 Northchase Drive, Suite 1300,                   Chief Executive Officer, US Oncology,
                                      Houston, Texas 77060                                  Inc.

Nancy Brinker                         9410 Alva Court                                       CEO - In Your Corner, Inc., a provider
                                      Dallas, Texas  75229                                  of health and wellness products and
                                                                                            services

Russell L. Carson                     320 Park Avenue, Suite 2500                           Partner - Welsh, Carson, Anderson &
                                      New York, New York  10022                             Stowe, an investment partnership

John T. Casey                         16825 Northchase Drive, Suite 1300,                   Former Chief Executive Officer,
                                      Houston, Texas 77060                                  Physician Reliance Network, Inc., now
                                                                                            a part time employee of physician
                                                                                            Reliance Network, Inc.

J. Taylor Crandall                    201 Main Street                                       Vice President and CFO of Keystone,
                                      Fort Worth, TX 76102                                  Inc., an investment company.

James E. Dalton, Jr.                  103 Continental Place                                 President, CEO and Director of Quorum
                                      Brentwood, Tennessee  37207                           Health Group, Inc., a health care
                                                                                            company

Robert W. Daly                        36 Washington Street, Suite 170                       Managing Director, MedEquity Investors,
                                      Wellesley Hills, MA 02481                             LLC, a health care venture capital
                                                                                            firm.

Stephen E. Jones, M.D.                3535 Worth Street                                     Physician, Texas Oncology, P.A.
                                      Dallas, Texas  75246

Stanley M. Marks, M.D.                816 Middle Street                                     Physician, Oncology-Hematology
                                      Pittsburgh, PA 15212                                  Associates

Richard B. Mayor                      700 Louisiana Ave, Ste. 1900                          Of Counsel, Mayor, Day, Caldwell &
                                      Houston, Texas 77002                                  Keeton, L.L.P.

Robert A. Ortenzio                    4718 Old Gettysburg Road                              President and Chief Operating Officer,
                                      Mechanicsburg, PA  17055                              Select Medical Corporation

Boone Powell, Jr.                     3500 Gaston Avenue                                    President and Chief Executive Officer,
                                      Dallas, TX  75246                                     Baylor Health Care System and Baylor
                                                                                            University Medical Center

Edward E. Rogoff, M.D.                2625 Craycroft Road, Suite 100                        Physician, Southwestern Radiation
                                      Tucson, AZ  85712                                     Oncology, Ltd.

Burton S. Schwartz, M.D.              800 E. 25th Street                                    Physician, Minnesota Oncology
                                      405 Piper Bldg.                                       Hematology, P.A.
                                      Minneapolis, Minnesota  55407
</TABLE>


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