IXION BIOTECHNOLOGY INC
DEF 14A, 1998-04-30
PHARMACEUTICAL PREPARATIONS
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                            SCHEDULE 14A INFORMATION
  Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act 1934


Filed by the Registrant [x]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[ ] Preliminary Proxy Statement
[ ] Confidential, for Use of the Commission Only (as permitted by Rule 14(a))
[x] Definitive Proxy Statement
[ ] Definitive Additional Materials
[ ] Soliciting Material Pursuant to Sec. 240.14a-11(c) or Sec. 240.14a-12

                            IXION BIOTECHNOLOGY, INC.


Payment of Filing Fee
[x] $125 per Exchange Act Rules.
[ ] $500 per each party to the controversy Pursuant to Exchange Act Rules.
[ ] Fee Computed on table below per Exchange Act Rules.
         1) Title of each class of securities to which transaction applies:

         2) Aggregate number of securities to which transaction applies:

         3) Per unit price or other  underlying  value of  transaction  computed
         pursuant to Exchange Act Rules:

         4) Proposed maximum aggregate value of transaction:

         5) Total fee paid:

[   ] Check box if any part of the fee is offset as provided by Exchange Act and
    identify  the  filing  for which  the  offsetting  fee was paid  previously.
    Identify the previous filing by registration  statement  number, or the Form
    or Schedule and the date of its filing.
         1) Amount Previously Paid:
         2) Form Schedule or Registration Statement No.:
         3) Filing Party:
         4) Date Filed:
===============================================================================
<PAGE>

                                      IXION



                    Notice of Annual Meeting of Stockholders
                                  June 12, 1998




         The  annual  meeting of  stockholders  of Ixion  Biotechnology,  Inc, a
Delaware  corporation  (the  "Company"),  will  be held  at the  Newark  Airport
Mariott,  Newark  International  Airport,  Newark, NJ 07114, on June 12, 1998 at
10:00 a.m., EDT, to:

         1. Elect five directors for a term of one year;

         2. Act upon the  ratification  of the  designation of Coopers & Lybrand
L.L.P. to audit the books and records of the Company for 1998.

         3. Transact such other business as may properly come before the meeting
or any adjournments or postponements thereof.

         Only  stockholders  of record as of the close of  business on April 13,
1998, will be entitled to notice of the annual meeting and to vote at the annual
meeting and any adjournments or postponements  thereof. If you are a stockholder
of record and plan to attend the meeting,  please return the proxy card with the
"Annual  Meeting" box marked.  Admission to the meeting will be on a first-come,
first served basis. Stockholders will be admitted upon verification of ownership
at the door.


                                    By Order of the Board of Directors,



                                    Mary Trew
                                    Secretary

Alachua, Florida
April 30, 1998


- --------------------------------------------------------------------------------
                                    IMPORTANT
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
     If you do not expect to attend the  meeting  in  person,  please  complete,
date,  and sign the enclosed  proxy and return it without  delay in the enclosed
envelope, which requires n additional postage if mailed in the United States.
- --------------------------------------------------------------------------------
<PAGE>
                            IXION BIOTECHNOLOGY, INC.
                              12085 Research Drive
                                Alachua, FL 32615




                                  April 30, 1998





                                 PROXY STATEMENT



         This proxy statement is furnished in connection  with the  solicitation
of proxies by the Board of Directors of Ixion Biotechnology, Inc. (the "Company"
or "Ixion"), for use at the 1998 annual meeting of stockholders on June 12, 1998
at 10:00 a.m. EDT, and at any postponements or adjournments  thereof. This proxy
statement  and  the  accompanying  proxy  card  are  expected  to be  the  first
distributed to stockholders on or about April 30, 1998.

         The cost of  solicitation  of proxies will be borne by the Company.  In
addition to the use of mails, proxies may be solicited by telephone by officers,
directors,  and regular employees of the Company, none of whom will be specially
compensated for such services.

         The Company's  annual report to stockholders  for the fiscal year ended
December 31, 1997, including audited financial statements, is included herewith,
but does not constitute a part of this proxy statement.

                              VOTING AT THE MEETING

         Holders  of  common  stock of the  Company,  par  value  $.01 per share
("Common  Stock"),  of  record at the close of  business  on April 13,  1998 are
entitled to vote at the meeting. As of that date, there were 2,472,194 shares of
Common Stock outstanding. Each stockholder entitled to vote shall have the right
to one vote for each share outstanding in such stockholder's name.

         The  Company  presently  has no other  class of stock  outstanding  and
entitled  to be voted at the  meeting.  The  presence  in  person or by proxy of
stockholders entitled to cast a majority of all votes entitled to be cast at the
meeting constitutes a quorum.

         Shares  cannot be voted at the  meeting  unless the holder of record is
present  in  person  or by  proxy.  The  enclosed  proxy  is a means  by which a
stockholder  may authorize  the voting of his or her shares at the meeting.  The
shares of Common Stock represented by each properly executed proxy will be voted
at the meeting in accordance with each  stockholder's  directions.  Stockholders
should  specify their choices by marking the  appropriate  boxes on the enclosed
proxy; if no choice has been specified,  the shares will be voted as recommended
by the Board of Directors.  If any other  matters are properly  presented at the
meeting for  action,  the proxy  holders  will vote the  proxies  (which  confer
discretionary  authority  to vote on such  matters)  in  accordance  with  their
judgement.

         Execution  of the  accompanying  proxy will not affect a  stockholder's
right to attend the meeting and vote in person.  Any stockholder  giving a proxy
has a right to revoke it by giving written notice of revocation to the Secretary
of the Company,  or by delivering a  subsequently  executed  proxy,  at any time
before the proxy is voted.

         Your proxy vote is important.  Accordingly,  please complete, sign, and
return the accompanying proxy whether or not you plan to attend the meeting.

                                       12

                              ELECTION OF DIRECTORS

         Proxies in the accompanying  form will be voted at the meeting,  unless
authority  to do so is  withheld,  in favor of the  election as directors of the
nominees named below.

         The  stockholders  will elect five directors at the 1998 annual meeting
for a term of one year expiring at the 1999 annual meeting of the  stockholders,
and until the election and qualification of successors (or until earlier removal
or  resignation).  In the event one or more of the named  nominees  is unable to
serve,  the persons  designated  as proxies may cast votes for other  persons as
substitute nominees. The Board of Directors has no reason to believe that any of
the nominees named below will be  unavailable,  or, if elected,  will decline to
serve.  Directors will be elected by a plurality of the votes cast at the annual
meeting.  Withheld votes will not count toward such  nominee's  achievement of a
plurality.

     Certain  information is set forth below for each nominee for director.  All
of the nominees  are  presently  directors  and were  previously  elected by the
stockholders,  except  Dr.  Karl-E.  Arfors,  who has been  nominated  to fill a
newly-created vacancy on the Board.

         The Board of  Directors  unanimously  recommends a vote FOR each of the
nominees.

Nominees for Director
<TABLE>
<CAPTION>


                                                                                                Year First
                           Principal Occupations During Past Five                                 Became
 Name of Director  Age        Years and Certain Directorships                                    Director
- ------------------- --  ------------------------------------------------------------------------ -----------
- ------------------- --  ------------------------------------------------------------------------ -----------
<S>                 <C> <C>                                                                      <C>
Weaver H. Gaines    54    Mr. Gaines is one of the founders of the Company and has been its        1993
                          Chairman and Chief Executive and a director since inception.  He was
                          also President from April 1993 to April 1994.  From April to November
                          1992, he was a member of Bush/Quayle 92.  He is also Chairman of
                          BIO+Florida,  the  Florida  biotechnology  trade
                          association, and a director of AquaGene, Inc.
- ------------------- --  ------------------------------------------------------------------------ -----------
- ------------------- --  ------------------------------------------------------------------------ -----------

David C. Peck       50    Mr. David Peck is one of the founders of Ixion and has been a director   1993
                          since inception.  Since April 1994, he has served as President and
                          Chief Financial Officer.  From September 1995, Mr. Peck has also been
                          Chief Executive Officer and Chief Operating Officer of BACOMPT, a
                          printing company located in Carmel, Indiana.  From 1992 until April
                          1994, he was the Chief Operating Officer of NEXCOM, the Navy Exchange
                          Service Command, a multi-billion dollar retail business.  Mr. Peck is
                          the brother of Dr. Peck, the Company's Chief Scientist.
- ------------------- --  ------------------------------------------------------------------------ -----------
- ------------------- --  ------------------------------------------------------------------------ -----------

David M. Margulies  46    Dr. Margulies is currently Executive Vice President and Chief            1994
                          Scientist of Synetic, Inc., a publicly-held company.  From July 1996
                          to January 1997, Dr. Margulies was a founder  and Chairman and CEO of
                          CareAgents, Inc, a developer of Internet-based clinical commerce
                          applications, which was acquired by Synetic in January 1997.  From
                          1991 to July 1996, Dr. Margulies was a Director, an Executive Vice
                          President,   and  Chief   Scientist   of  Cerner
                          Corporation, a publicly-held company.
- ------------------- --  ------------------------------------------------------------------------ -----------
- ------------------- --  ------------------------------------------------------------------------ -----------

Vincent P. Mihalik  47    Mr. Mihalik is presently Executive Vice President, Diagnostics           1995
                          Division, F. Hoffmann-LaRoche, the parent company of Boehringer
                          Mannheim Group.  Until October of 1996, he was  Senior Vice President
                          Global Marketing for the Diabetes Care Business Unit of Boehringer
                          Mannheim Corporation.  He joined Boehringer Mannheim in 1990 and held
                          the position of President, Patient Care Systems Division.
- ------------------- --  ------------------------------------------------------------------------ -----------
- ------------------- --  ------------------------------------------------------------------------ -----------

Karl-E. Arfors      61    Dr. Arfors has been President of Experimental Medicine, Inc., since    Nominee
                          1993.  His professional career includes positions with the Liposome
                          Company and Pharmacia AB, as well as President of the La Jolla
                          Institute for Experimental Medicine.
- ------------------- --  ------------------------------------------------------------------------ -----------
</TABLE>

Committees of the Board of Directors

         The Bylaws provide that the Board may designate an executive  committee
and other committees,  each of which shall consist of one or more directors, and
the Board  annually  elects from its members of an Audit and Benefits  Committee
and an Executive Committee.

         Audit and  Benefits  Committee.  The members of the Audit and  Benefits
Committee are Dr.  Margulies and Mr. Mihalik,  non-employee  directors,  and Mr.
Peck,  the Company's  President.  Upon the election of Dr. Arfors as a director,
Dr. Arfors will be appointed to this  Committee in place of Mr. Peck,  such that
the Committee will thereafter be composed exclusively of non-employee directors.
This  Committee,  which  met  twice  during  1997,  recommends  to the Board the
engagement of  independent  auditors,  reviews the  professional  services to be
rendered by the independent auditors,  the scope of their audit, their fees, and
the results of their engagement. The independent auditors meet periodically with
the Committee and have  unrestricted  access to the Committee.  The Committee is
also  responsible for developing and executing plans for the compensation of the
executive  officers.  Additionally,  the  Committee  administers  the  terms and
provisions  of the 1994  Stock  Option  Plan (the  "Option  Plan") and the Board
Retainer  Plan,  including  the  determination  of the  individuals  eligible to
receive awards, the individuals to whom awards should be granted,  the nature of
the awards to be granted, and the exercise price, vesting schedule,  and term of
options or awards to be granted.

     Executive Committee.  The members of the Executive Committee are Mr. Gaines
and Mr.  Peck.  The  Executive  Committee  has all of the  powers  of the  Board
permitted  under the  Delaware  corporation  law.  There were no meetings of the
Executive  Committee during 1997, and all of its actions were taken by unanimous
consent.

Board Meetings and Attendance of Directors

         The  Board of  Directors  had three  meetings  in 1997.  All  directors
attended  more than 75% of the  aggregate of (i) the total number of meetings of
the Board held while they were  members,  and (ii) the total  number of meetings
held by all Committees of the Board.

Compensation of Directors

         Employees and  consultants of the Company who are also directors of the
Company  receive  no  additional  remuneration  for  fulfilling  their  role  as
director.



<PAGE>


         Pursuant to the Board Retainer Plan, as amended, non-employee directors
receive a grant of 5,000 shares of Common Stock upon election to the Board, and,
during the duration of the Plan, will receive 1,000 shares annually  thereafter,
immediately  following  the annual  meeting at which they are  reelected  to the
Board.  They also  receive  reimbursement  of their  expenses  to  attend  Board
meetings.  In June of 1997,  Dr.  Margulies and Mr.  Mihalik each received 1,000
shares under the Board  Retainer Plan. In addition,  non-employee  directors are
eligible  to receive  options  under the terms of the 1994 Stock  Option Plan as
determined by the Audit and Benefits Committee.  Non-employee  directors who are
members of the Audit and  Benefit  Committee  may not be  awarded  discretionary
option  grants,  but will receive a grant of options to purchase 2,000 shares of
the Company's  Common Stock upon  appointment to the  Committee,  and options to
purchase an additional  2,500 shares  annually  thereafter.  Options vest over a
five-year  period,  with an exercise price equal to the fair market value of the
Company's  Common Stock on the date of grant.  In 1997,  Dr.  Margulies  and Mr.
Mihalik each received an automatic annual grant under the 1994 Stock Option Plan
of a nonqualified option to purchase 2,500 shares of Common Stock at an exercise
price of $10.00 per share.

Security Ownership of Directors and Officers

         The  following  table sets forth  certain  information  with respect to
beneficial  ownership of the Company's  Common Stock as of February 28, 1998, by
the  Company's  executive  officers  and by all  directors  and  officers of the
Company as a group.



Name                                      Number of Shares           Percent
- ---------------------------------- ------------------------------ -------------
- ---------------------------------- ------------------------------ -------------

Ammon B. Peck, Ph.D...............        655,000 (1)(4)            26.2%
- ---------------------------------- ------------------------------ -------------
- ---------------------------------- ------------------------------ -------------

Weaver H. Gaines..................        553,512 (2)(4)            22.2%
- ---------------------------------- ------------------------------ -------------
- ---------------------------------- ------------------------------ -------------

David C. Peck.....................        417,234 (3)(4)            16.7%
- ---------------------------------- ------------------------------ -------------
- ---------------------------------- ------------------------------ -------------

David M. Margulies, M.D...........         18,917 (4)                 (5)
- ---------------------------------- ------------------------------ -------------
- ---------------------------------- ------------------------------ -------------

Vincent P. Mihalik................         12,742 (4)                 (5)
                                           ----------                 ---
- ---------------------------------- ------------------------------ -------------
- ---------------------------------- ------------------------------ -------------

All officers and directors
as a group  (6 persons) ..........      1,663,404 (4)               66.6%
                                        =============               =====
- ---------------------------------- ------------------------------ -------------

     (1)  Includes  50,000  shares  held by Dr.  Peck's  wife in  trust  for her
brothers as to which Dr. Peck disclaims beneficial ownership.
     (2) Includes 40,000 shares held by WABS Associates,  a general  partnership
composed of Mr. Gaines and his three siblings.  Mr. Gaines disclaims  beneficial
ownership of 30,000 of such shares.
     (3) Includes  1,000 shares and 250 warrants  held by Mr. Peck's wife, as to
which Mr. Peck disclaims beneficial ownership.
     (4) Includes  shares which could be acquired within 60 days of February 28,
1998 through the exercise of stock  options or the  conversion  of the Company's
Unsecured  Convertible  Debt as follows:  Dr. Peck (5,000  shares),  Mr.  Gaines
(5,952 shares),  Mr. Peck (12,250 shares),  Dr.  Margulies  (2,917 shares),  Mr.
Mihalik (1,742 shares), and an additional officer (6,000 shares).
     (5) Less than 1.0% (including shares which could be acquired within 60 days
of February 28, 1998 through the exercise of  outstanding  options).  Percent is
calculated  based on  actual  shares  outstanding  plus  shares  exercisable  by
officers or directors within 60 days.

Security Ownership of Certain Beneficial Owners

         Set forth below is certain  information  with respect to those  persons
who are known to the Company to own  beneficially  more than five percent of the
Company's Common Stock as of February 28, 1998.

- ---------------------------------- ------------------------------ ------------

Name and Address of  (1)                  Number of Shares            Percent
 Beneficial Owners
- ---------------------------------- ------------------------------ -------------

Ammon B. Peck, Ph.D...............          655,000 (2)(5)              26.2%
- ---------------------------------- ------------------------------ -------------
- ---------------------------------- ------------------------------ -------------

Weaver H. Gaines..................          553,512 (3)(5)              22.2%
- ---------------------------------- ------------------------------ -------------
- ---------------------------------- ------------------------------ -------------

David C. Peck.....................          417,234 (4)(5)              16.7%
- ---------------------------------- ------------------------------ -------------

     (1) Address is 12085 Research Drive, Alachua, FL 32615.
     (2)  Includes  50,000  shares  held by Dr.  Peck's  wife in  trust  for her
brothers as to which Dr. Peck disclaims beneficial ownership.
     (3) Includes 40,000 shares held by WABS Associates,  a general  partnership
composed of Mr. Gaines and his three siblings.  Mr. Gaines disclaims  beneficial
ownership of 30,000 of such shares.
     (4) Includes  1,000 shares and 250 warrants  held by Mr. Peck's wife, as to
which Mr. Peck disclaims beneficial ownership.


<PAGE>


     (5) Includes  shares which could be acquired within 60 days of February 28,
1998 through the  conversion  of the  Company's  Unsecured  Convertible  Debt as
follows:  Dr. Peck (5,000  shares),  Mr.  Gaines  (5,952  shares),  and Mr. Peck
(12,250 shares).  Percent is calculated based on actual shares  outstanding plus
shares exercisable by officers or directors within 60 days.

         The  Company  is not aware of any  arrangements,  including  pledges of
securities,  the execution of which may at a subsequent  time result in a change
in control of the Company.

Summary Compensation Table

         The following  table  summarizes the  compensation of those persons who
were, at December 31, 1997, the Company's  Chairman and Chief Executive Officer,
its  President,  its Senior Vice  President  and Chief  Scientist,  and its Vice
President,  Operations and Regulatory Affairs,  for the years ended December 31,
1995, 1996, and 1997.
<TABLE>
<CAPTION>

                           Summary Compensation Table
- -------------------------------------- ----------------------------- ------------------------------------------

                                            Annual Compensation            Long-Term Compensation Awards

- -------------------------------------- ----------------------------- ------------------------------------------
- ------------------------------ ------- ---------- ---------- ------- ---------------- -------------------------

                                       Deferred   Cash       All       Restricted            Securities
            Name               Year     Salary    Salary     Other    Stock Awards    Underlying Options/SARs
            ----               ----     ------    ------     -----    ------------    -----------------------
- ------------------------------ ------- ---------- ---------- ------- ---------------- -------------------------
- ------------------------------ ------- ---------- ---------- ------- ---------------- -------------------------
<S>                            <C>     <C>        <C>        <C>     <C>              <C>
Weaver H. Gaines (1)......     1995     $31,250    $43,750     $0          $0                    0
Chairman and CEO               1996     $25,000    $60,000     $0          $0                    0
                               1997     $23,750    $71,250     $0          $0                    0
- ------------------------------ ------- ---------- ---------- ------- ---------------- -------------------------
- ------------------------------ ------- ---------- ---------- ------- ---------------- -------------------------

David C. Peck (2).........     1995     $35,000    $25,000     $0          $0                    0
President & CFO                1996     $25,000    $35,000     $0          $0                    0
                               1997     $20,000    $40,000     $0          $0                    0
- ------------------------------ ------- ---------- ---------- ------- ---------------- -------------------------
- ------------------------------ ------- ---------- ---------- ------- ---------------- -------------------------

Ammon B. Peck (3).........     1995     $ 7,500    $22,500     $0          $0                    0
Sr. V.P. & Chief Scientist     1996     $ 5,000    $35,000     $0          $0                    0
                               1997     $16,667    $33,333     $0          $0                    0
- ------------------------------ ------- ---------- ---------- ------- ---------------- -------------------------
- ------------------------------ ------- ---------- ---------- ------- ---------------- -------------------------

John L. Tedesco, MS.......
V.P. Operations & Reg.         1997       $0       $58,420     $0          $0                  6,000
Affairs
- ------------------------------ ------- ---------- ---------- ------- ---------------- -------------------------
</TABLE>

     (1) Mr. Gaines joined the Company at its inception in March 1993.
     (2) Mr. Peck joined the Company in April 1994. He is paid a consulting  fee
rather than a salary. (3) Dr. Peck began consulting for the Company on June 1, 
1994. He is paid a consulting fee rather than a salary.
     (4) Mr. Tedesco joined the Company in January 1997 and resigned in April of
1998.  Brandywine  Consulting  Group,  of  which  he is  president,  was  paid a
consulting fee based entirely on his services.

Executive Compensation and Employment Arrangements

         In August,  1994,  the Board of Directors  adopted an annual  incentive
compensation  plan (the  "Annual  Bonus  Plan"),  administered  by the Audit and
Benefits  Committee,  pursuant  to which  officers  and key  consultants  may be
awarded cash bonuses  (deferred  unless the Company has  sufficient  cash to pay
such bonuses prudently),  based on the financial performance of the Company. For
1997, the Audit and Benefits Committee  determined that awards could range up to
50% of a participant's  base salary or consulting fee,  depending on their rank.
No awards  under the Annual Bonus Plan were made for 1996.  Awards,  if any, for
1997, will be determined following the 1998 annual meeting.



<PAGE>


         In  January,   1994,   the  Board  of  Directors   adopted  a  Deferred
Compensation  Plan for  officers,  key  employees,  and key  consultants  of the
Company,  permitting  such  persons to defer the  receipt of all or a portion of
their compensation.  Under the Deferred  Compensation Plan, an unfunded deferred
compensation account is established for each participant. The only obligation of
the Company  regarding  such  account is to make the  payments  when they become
payable  if the  Company  has  sufficient  cash to do so  prudently.  Any amount
credited to such account is solely for record-keeping,  and is not considered to
be held in trust or in escrow or in any way vested in the participant.  Payments
under the Deferred  Compensation  Plan are to be made only upon  termination  of
employment (which may be by death, disability, retirement, or otherwise) and may
be in a lump sum or as an annuity.  In the case of certain senior  participants,
if  termination is by death or dismissal  without cause,  at the election of the
participant,  the balance in his account may be  converted  into Common Stock of
the  Company at a price per share not  greater  than the lowest  price per share
(adjusted  for stock  splits,  stock  dividends,  the  issuance  of  convertible
securities,  warrants,  or options,  or other  dilution)  at which shares of the
Company's  Common Stock have been issued (or agreed to be issued) at any time in
the 365 days preceding the date of termination.  A termination is deemed without
cause  for  substantially  the  same  occurrences  described  under  "Employment
Agreements," below.  Amounts in the account bear interest,  compounded annually,
at a rate  established  by the Board of  Directors,  which was 8.0% during 1997.
Effective January 1, 1998, the rate established by the Board is 6.54%. A portion
of compensation and all interest during 1997 were deferred by the officers.

         The  Company  has  entered  into  written  employment  agreements  (the
"Employment Agreements") with two of its executive officers,  Messrs. Gaines and
D. Peck (who also has a consulting  agreement with the Company which essentially
duplicates  the terms of the  Employment  Agreement),  which provide for initial
annual base compensation of $90,000 and $60,000, respectively. Base compensation
levels are to be reviewed at least annually.  Upon a determination  by the Board
that the Company has  obtained  adequate  financing,  base  compensation  may be
increased  to not less than the average  cash base  compensation  reported by an
appropriate salary survey (as determined by the Board) for executive officers at
biotechnology companies of equivalent size and status. The effective date of the
Employment  Agreements is August 31, 1994,  and the current term of each expires
December  31, 1999,  renewable  automatically  for one year terms unless  either
party gives written notice of termination at least 92 days before the end of the
then current term. Annual bonus compensation, if any, shall be determined by the
Board of Directors.

         The  Employment  Agreements  provide  that the Company has the right to
terminate  the executive at any time upon 60 days'  notice.  A  termination  for
cause (as defined in the  Employment  Agreements) is effective  without  further
benefits,  upon a finding by the Board of Directors.  Termination  without cause
(as defined in the Employment  Agreements),  or termination by the executive for
"Good Reason" (as defined in the Employment  Agreements) requires the Company to
pay severance  benefits  equal to the aggregate  base salary at the then current
rate  payable  through the end of the then current  term,  but not less than two
times the  executive's  base  compensation.  In  addition,  the Company must pay
annual  bonus   compensation   calculated  in  accordance  with  the  Employment
Agreements. Finally, all restricted stock is immediately vested, all outstanding
stock options are immediately  vested and  accelerated,  and the executives have
the right to purchase  Common Stock of the Company  pursuant to the terms of the
Subordinated Note Agreement and the Deferred  Compensation Plan.  Termination is
deemed  without  cause or for "Good  Reason" if (i) there is a reduction  in the
executive's  annual  aggregate  compensation  or  benefits,  (ii)  there  is  an
involuntary diminution in the executive's position,  powers, authority,  duties,
or  responsibilities,  or (iii)  there is a  material  breach of the  Employment
Agreement by the Company.

         The  Employment  Agreements  contain  covenants  that an executive must
refrain from engaging in any business  competitive  with the Company  during the
period of his employment and for six months after termination or resignation and
must not use,  disclose or make  accessible  to any third party any  proprietary
information of the Company during the period of his  employment,  or thereafter.
All  inventions  relating  to oxalate  technology,  or  biotechnology  generally
conceived  while  rendering  services  to the  Company  must be  assigned to the
Company.

         The Company has an exclusive consulting agreement expiring in 2000 with
Dr. Ammon B. Peck for consulting services relating to the Company's business and
technology. The fee is $50,000 per year. Dr. Peck is obligated to devote 48 days
of service per year to the Company, including travel time, and has agreed not to
engage in competitive activities with Ixion during the term of the agreement, or
for two years  thereafter.  Subject to the  provisions of Dr. Peck's  employment
agreement with the  University of Florida,  Dr. Peck has agreed to assign to the
Company any inventions or intellectual  property  rights  developed by him while
performing services under the agreement. The agreement may be canceled by either
party on 30 days' written notice.


<PAGE>


Option Tables

         The following table sets forth certain information concerning all stock
option grants to the Company's executive officers to date.
<TABLE>
<CAPTION>

                      Option/SAR Grants in Last Fiscal year
                               (Individual Grants)
- --------------------------------- -------------------------- ------------------------ ---------------- -------------

                                    Number of Securities           % of Total
                                   Underlying Options/SARs    Options/SARs Granted    Exercise Price    Expiration
              Name                         Granted           to Employees in Fiscal      Per Share         Date
                                                                      Year
- --------------------------------- -------------------------- ------------------------ ---------------- -------------
- --------------------------------- -------------------------- ------------------------ ---------------- -------------
<S>                               <C>                        <C>                      <C>              <C>
      John L. Tedesco (1)                   3,000                     33.7%                $5.00         2/10/02
  VP Operations & Reg. Affairs              3,000                     33.7%                $5.00         10/23/02
- --------------------------------- -------------------------- ------------------------ ---------------- -------------
</TABLE>

     (1) Warrants  were granted to  Brandywine  Consulting,  Inc.,  of which Mr.
Tedesco was President.

         The following table sets forth certain  information  concerning  option
exercises  and  option  holdings  under the Plan as of  December  31,  1997 with
respect to each of the Company's executive officers.
<TABLE>
<CAPTION>

            Aggregated Options/SAR Exercises in Last Fiscal Year and
                        Fiscal Year-end Option/SAR Values

- ----------------------------------------- ------------------------------------ -------------------------------------

                                            Number of Securities Underlying     Value of Unexercised In-The-Money
                                          Unexercised Options/SARs at FY-end          Options/SARs at FY-end
                  Name                        Exercisable/Unexerciseable            Exercisable/Unexerciseable
- ----------------------------------------- ------------------------------------ -------------------------------------
- ----------------------------------------- ------------------------------------ -------------------------------------
<S>                                       <C>                                  <C>
          John L. Tedesco (1)                           6,000/0                           $60,000/$0 (1)
      VP Operations & Reg. Affairs
- ----------------------------------------- ------------------------------------ -------------------------------------
</TABLE>

      (1) Warrants  were granted to  Brandywine  Consulting,  Inc., of which Mr.
Tedesco  was  President.  Value  is based on the  public  offering  price of the
Company's Units. There is no trading market for the Company's Common Stock.

                  CERTAIN RELATIONSHIPS AND RELATED TRANSACTION

         The  following  are  transactions  since  January 1, 1997  between  the
Company and any officer,  director,  director nominee, or the imediate family of
any such persons.

         On April 16, 1996,  the Chairman  and Chief  Executive  Officer and the
President of the Company each entered into an agreement to extend the Company up
to $25,000 in the form of a bridge  loan.  The loans bear cash  interest  at the
rate 8% (which can be reset  annually,  at the election of either party,  to the
prime rate in effect on January 1 of any given year plus 3%),  paid  monthly and
upon repayment of the principal.  In addition,  the Chairman,  on June 21, 1996,
agreed  to  increase  his  loan  commitment  to an  amount  up to  $150,000,  if
necessary,  to enable the Company to continue  operations.  $75,000 was borrowed
and was outstanding under these facilities at December 31, 1997.

         In December 1996, the Company entered into a consulting  agreement with
Brandywine  Consulting,  Inc., a company whose President,  John L. Tedesco,  was
also Vice President - Operations and Regulatory  Affairs of the Company.  During
1997,  Brandywine  Consulting was paid $58,420, was reimbursed for Mr. Tedesco's
expenses,  and received upon the  achievement of certain  milestones,  five-year
warrants for an aggregate of 6,000 shares of Common Stock,  exercisable at $5.00
per share. Mr. Tedesco resigned as Vice President on April 4, 1998.

         In  December  1997,  the Company  engaged the  services of a printer in
connection with its public offering.  The printer is managed and partly owned by
the Company's President. Through December 31, 1997, the printer had not rendered
any service, and accordingly had not been paid.



<PAGE>


         It is the Company's policy that any material transactions or loans, and
any forgiveness of loans, between officers,  directors, or material shareholders
and the Company  must be approved  by a majority  of the  Company's  independent
directors, if any, who do not have an interest in the transaction.  Furthermore,
all such  transactions  or loans must be entered  into on terms that are no less
favorable to the Company than those that can be obtained from unaffiliated third
parties.  All of the above transactions were entered into in compliance with the
Company's policy.

                             DESIGNATION OF AUDITORS

         Upon the recommendation of the Audit and Benefits Committee,  the Board
of Directors  has  designated  Coopers & Lybrand  L.L.P.  to audit the books and
accounts of the Company for the year ending  December 31, 1998, and will offer a
resolution at the annual meeting to ratify the designation.

                                 OTHER BUSINESS

         The Board of Directors is not aware of any matters not set forth herein
that may come before the meeting.  If, however,  further business properly comes
before  the  meeting,  the  persons  named in the  proxies  will vote the shares
represented thereby in accordance with their judgement.

                       1999 ANNUAL MEETING OF SHAREHOLDERS

         If any stockholder  intends to present a proposal for  consideration at
the 1999 annual meeting of  stockholders,  such proposal must be received by the
Company not later than January 1, 1999,  for  inclusion,  pursuant to Rule 14a-8
under the Exchange  Act, in the  Company's  proxy  statement  for such  meeting.
<PAGE>
                                      PROXY
                            IXION BIOTECHNOLOGY, INC.
                    PROXY SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JUNE 12, 1998




         The  undersigned  hereby appoints Weaver H. Gaines or David C. Peck, or
either of them,  as attorney  and proxy of the  undersigned,  with full power of
substitution  and  resubstitution,  to vote all of the shares of Common Stock of
Ixion Biotechnology,  Inc. (the "Company") which the undersigned may be entitled
to vote at the Annual Meeting of  Stockholders  to be held at the Newark Airport
Mariott,  Newark  International  Airport,  Newark,  NJ 07114,  on June 12, 1998,
commencing  at 10:00 a.m.,  local  time,  and at any and all  postponements  and
adjournments  thereof,  with all powers that the  undersigned  would  possess if
personally  present,  upon  and in  respect  of  the  following  matters  and in
accordance with the following instructions.

         UNLESS A CONTRARY DIRECTION IS INDICATED,  THIS PROXY WILL BE VOTED FOR
ALL  NOMINEES  FOR  DIRECTOR  LISTED IN  PROPOSAL 1 AND FOR  PROPOSAL 2, AS MORE
SPECIFICALLY  DESCRIBED IN THE PROXY  STATEMENT.  IF SPECIFIC  INSTRUCTIONS  ARE
INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH.

         YOU MAY  REVOKE  THIS PROXY AT ANY TIME PRIOR TO THE VOTE AT THE ANNUAL
MEETING.

                 PLEASE COMPLETE, DATE, AND SIGN THIS PROXY AND
                     RETURN IT IN THE ACCOMPANYING ENVELOPE.

THE BOARD OF DIRECTORS  RECOMMENDS  A VOTE FOR THE NOMINEES FOR DIRECTOR  LISTED
BELOW AND A VOTE FOR PROPOSAL 2

1. To elect five  directors  to hold  office  until the 1999  Annual  Meeting of
Stockholders.

Nominees:  Weaver H.  Gaines,  David C.  Peck,  David M.  Margulies,  Vincent P.
           Mihalik, and Karl-E. Arfors

   For                  Withhold Authority                        Abstain
   ---                        ---                                   ---


For all nominees except as noted



2. To ratify the  designation  of  Coopers & Lybrand  LLP to audit the books and
accounts of the Company for the fiscal year ended December 31, 1998.

   For                      Against                               Abstain
   ---                        ---                                   ---



Please sign exactly as name appears   Signature:            Date            1998
on this proxy.  When signing as       Signature:            Date            1998
attorney, executor, administrator, 
trustee or guardian, please give
full title.  If more than one 
trustee, all should sign.  All joint
owners must sign.


                ---------                                   ----------
            MARK HERE FOR CHANGE                        MARK HERE IF YOU
            OF ADDRESS AND NOTE                         PLAN TO ATTEND
            CHANGE ABOVE                                THE ANNUAL MEETING


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