IXION BIOTECHNOLOGY INC
10QSB/A, 1999-08-17
PHARMACEUTICAL PREPARATIONS
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================================================================================

                     U.S. SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                  -------------

                                   FORM 10-QSB/A

   [X] QUARTERLY REPORT UNDER SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE

                                   ACT OF 1934

                  For the quarterly period ended June 30, 1999

                                       or

                              [ ] TRANSITION REPORT
                               UNDER SECTION 13 OR
                                  15 (d) OF THE
                              EXCHANGE ACT OF 1934
                               For the transition
                                 period from to

                                  -------------

                        Commission file number: 333-34765

                           Ixion Biotechnology, Inc..

        (Exact Name of Small Business Issuer as Specified in Its Charter)

                                  -------------

              Delaware                                59-3174033

        (State of incorporation)          (I.R.S. Employer Identification No.)

                          13709 Progress Blvd., Box 13
                                Alachua, FL 32615
                    (Address of principal executive offices)

                   Registrant's telephone number: 904-418-1428

                                  -------------

Check whether the issuer: (1) filed all reports required to be filed by Section
13 or 15(d) of the Exchange Act during the past 12 months (or for such shorter
period that the registrant was required to file such reports), and (2) has been
subject to such filing requirements for the past 90 days.

Yes  X      No

The number of shares of the registrant's common stock, par value $0.01 per
share, outstanding as of July 31, 1999 was 2,514,414.

================================================================================



<PAGE>


4

                            Ixion Biotechnology, Inc.
                               Index to Form 10QSB
<TABLE>
<CAPTION>

Part I - Financial Information                                                                    Page
                                                                                                  ----

Item 1.  Financial Statements (unaudited)
<S>         <C>                                                                                     <C>

            Condensed Balance Sheet - June 30, 1999..................................................2

            Condensed Statements of Operations - Three Months and Six Months
            Ended June 30, 1999 and 1998 and for the period March 25, 1993
            (Date of Inception) through June 30, 1999................................................3

            Condensed Statements of Cash Flows - Six Months Ended June 30, 1999
            and 1998 and for the period March 25, 1993
            (Date of Inception) through June 30, 1999................................................5

            Notes to Condensed Financial Statements..................................................6

Item 2.  Management's Discussion and Analysis of Financial Condition and
            Results of Operations or Plan of Operation...............................................8

Part II - Other Information

Item 2.  Changes in Securities and Use of Proceeds..................................................15

Item 4.  Submission of Matters to a Vote of Security Holders........................................15

Item 5.  Other Information..........................................................................16

Item 6.  Exhibits and Reports on Form 8-K...........................................................16

Signatures..........................................................................................17

Exhibit Index.......................................................................................17
</TABLE>


                                       1
<PAGE>



Part I.  Financial Information
Item 1.  Financial Statements

Condensed Balance Sheet
June 30, 1999
Unaudited

                                     Assets

Current  Assets:
   Cash and cash equivalents                                           $ 81,016
   Accounts receivable                                                    6,916
   Prepaid expenses                                                       1,359
   Other current assets                                                     500
          Total current assets                                         --------
                                                                         89,791
                                                                       --------
Property and Equipment, net                                             106,924

Other Assets:
    Patents and patents pending, net                                    327,435
    Other...                                                              6,705
                                                                       --------
                 Total other assets                                     334,140
                                                                       --------
                 Total Assets                                          $530,855
                                                                    ===========

                       Liabilities and Capital Deficiency

Current Liabilities:
    Accounts payable                                                   $ 35,923
    Bridge loans payable to officers                                    415,000
    Current portion of notes payable                                      9,716
    Convertible note payable                                            300,000
    Accrued expenses                                                     47,164
    Interest payable                                                     46,605
                                                                       --------
                 Total current liabilities                               854,408
                                                                       --------
Long-Term Liabilities:
    Notes payable                                                       674,432
    Liability under research agreement                                   42,317
    Deferred rent, including accrued interest                            23,213
    Deferred fees and salaries, including accrued interest              840,562
                                                                       --------
                  Total long-term liabilities                         1,580,524
                                                                     ----------
                  Total liabilities                                   2,434,932
                                                                      ---------

Capital Deficiency:
    Common stock, $.01 par value; authorized 4,000,000, issued and
       outstanding 2,514,014 shares at June 30                           25,144
    Common stock warrants outstanding                                    35,494
    Additional paid-in capital                                        1,625,888
    Deficit accumulated during the development stage                 (3,383,653)
    Less unearned compensation                                         (206,950)
                                                                   ------------
                  Total capital deficiency                           (1,904,077)
                                                                   ------------
Total Liabilities and Capital Deficiency                           $    530,855
                                                                   ============

See accompanying notes to condensed financial statements


                                       2
<PAGE>


Statements of Operations


                                                         Three Months Ended
                                                               June 30,
                                                       __1999__        __1998__
                                                              Unaudited
Revenues:...
   Income under research agreement                    $       0      $        0
   Income from SBIR Grant                                     0               0
   Interest income                                          915              69
   Other income                                             250           1,295
                                                      ---------      ----------
            Total revenues                                1,165           1,364
                                                      ---------      ----------

Expenses:...
  Operating, general and administrative                  88,085          80,909
  Research and development                              129,514         101,310
  Interest..                                             37,559          28,204
                                                      ---------      ----------
            Total expenses                              255,158         210,423
                                                      ---------      ----------

Net Loss....                                          $(253,993)     $(209,059)
                                                      =========      ==========

Basic and Diluted Net Loss per Share                  $   (0.10)     $   (0.08)
                                                      =========      ==========

Weighted Average Common Shares                        2,514,014       2,475,201
                                                      =========      ==========






















See accompanying notes to condensed financial statements



                                       3
<PAGE>
Statements of Operations
<TABLE>
<CAPTION>

                                                                                                For the Period
                                                                                                   March 25,
                                                                                                  1993 (Date
                                                                                                 of inception)
                                                     Six Months Ended                              through
                                                        June 30,                                   June 30,
                                               __1999__         __1998__                         ____1999____
                                                       Unaudited                                   Unaudited
<S>                                         <C>                <C>                                <C>

Revenues:...
   Income under research agreement            $       0       $        0                        $     275,001
   Income from SBIR Grant                             0                0                               91,650
   Interest income                                  963              215                               24,395
   Other income                                     695           2, 276                               18,500
                                               --------        ---------                         ------------
            Total revenues                        1,658            2,491                              409,546
                                               --------        ---------                         ------------
Expenses:...
  Operating, general and administrative         178,819          199,793                            1,647,326
  Research and development                      238,166          188,872                            1,748,903
  Interest..                                     74,729           56,594                              396,971
            Total expenses                      491,714          445,259                            3,793,199
                                               --------         --------                          -----------
Net Loss....                                 $ (490,056)       $(442,768)                        $ (3,383,653)
                                             ==========        =========                         ============
Net Loss per Share (Basic)                   $    (0.19)       $   (0.18)
                                             ===========       =========

Weighted Average Common Shares                 2,514,001       2,471,228
                                             ===========       =========
</TABLE>






















See accompanying notes to condensed financial statements

                                       4

<PAGE>


Statements of Cash Flows
<TABLE>
<CAPTION>

                                                                                                                   For the Period
                                                                                                                   March 25, 1993
                                                                                Six Months                      (Date of inception)
                                                                              Ended June 30,                          through
                                                                          1999           1998                      June 30, 1999
                                                                        --------       --------                    -------------
                                                                                Unaudited                            Unaudited
<S>                                                                  <C>            <C>                           <C>

Cash Flows from Operating Activities
    Net loss                                                           $(490,056)      $(442,768)                  $ (3,383,653)
    Adjustments to reconcile net loss to net cash used in
        operating activities:

 ............Depreciation                                                  12,711           5,928                         50,566
 ............Amortization                                                   2,234           1,578                          8,234
 ............Amortization of debt discount                                 28,584          28,584                        161,976
 ............Stock warrants issued under license agreement                      -               -                         20,465
 ............Stock options/warrants issued for consulting services              -               -                         30,000
 ............Stock compensation                                            81,650          50,181                        465,853
 ............Decrease (increase) in prepaid expenses and
 ............    other current assets                                        (283)            841                         (1,684)
 ............Decrease (increase) in accounts receivable                    (5,000)           (291)                        (6,916)
 ............Increase (decrease) in liability under
 ............    research agreement                                             -               -                         42,317
 ............Increase (decrease) in accounts payable and
 ............    accrued expenses                                         (34,998)          6,921                        163,561
 ............Increase in deferred fees and salaries                       121,286         119,747                        814,012
 ............Increase in deferred rent                                      1,118           7,557                         23,213
                                                                        -------         --------                     -----------
 ............    Net cash used in operating activities                   (212,757)       (211,722)                    (1,611,055)
                                                                        --------        --------                     -----------

Cash Flows from Investing Activities:
     Purchase of property and equipment                                  (58,553)              -                       (102,850)
     Organization Costs                                                        -               -                           (436)
     Payments for patents and patents pending                            (39,443)        (29,156)                      (323,558)
                                                                        --------         --------                    -----------
 ............   Net cash used in investing activities                     (97,996)        (29,156)                      (426,844)
                                                                        --------         --------                    -----------

Cash Flows from Financing Activities:
     Loans from officers                                                  90,000                -                       445,307
     Proceeds from issuance of convertible notes payable                 300,000                -                     1,087,270
     Proceeds from issuance of common stock                                1,000          195,500                       756,900
     Proceeds from issuance of subordinated notes
               payable to related parties                                      -           70,000                             0
     Principal reductions in notes payable                                (9,793)          (6,282)                      (33,738)
     Payment of deferred offering costs                                   (8,070)         (43,822)                     (124,631)
     Payment of loan costs                                                     -                -                       (12,194)
                                                                        --------           -------                    ----------
 ............   Net cash provided by (used in)
 ............     financing activities                                    373,137           215,396                    2,118,915
                                                                        --------           -------                    ----------
Net Increase (Decrease) In Cash and Cash Equivalents                      62,383           (25,482)                      81,016

Cash and Cash Equivalents at Beginning of Period                          18,633            44,443                            -
                                                                        --------           -------                    ----------
Cash and Cash Equivalents at End of Period                              $ 81,016           $18,961                    $   81,016
                                                                        ========           =======                    ==========


</TABLE>



See accompanying notes to condensed financial statements



                                       5
<PAGE>


Notes to Condensed Financial Statements
Six Month Period Ended June 30, 1999

1.    Basis Of Presentation:

      The accompanying unaudited condensed financial statements for the three
      and six months ended June 30, 1998 and 1999, and for the period March 25,
      1993 (date of inception) through June 30, 1999, have been prepared in
      accordance with generally accepted accounting principles for interim
      financial information. Accordingly, they do not include all the
      information and footnotes required by generally accepted accounting
      principles for complete financial statements. These interim financial
      statements should be read in conjunction with the December 31, 1998
      financial statements and related notes included in the Company's Annual
      Report on Form 10-KSB for the year ended December 31, 1998. In the opinion
      of the Company, the accompanying unaudited condensed financial statements
      contain all adjustments, consisting only of normal recurring accruals,
      necessary to present fairly the Company's financial position, results of
      operations, and cash flows for the periods presented. The results of
      operations for the interim period ended June 30, 1999 are not necessarily
      indicative of the results to be expected for the full year.

2.    Notes Payable:

      On April 16, 1999, in connection with an agreement in principle between
      the Company and Q-Med AB, described below in Note 6, Q-Med advanced
      $300,000 to the Company. The loan, which is convertible at the Company's
      election, will be converted into 150,000 restricted shares of the
      Company's common stock.

3.    Income Taxes:

      The components of the Company's net deferred tax asset and the tax effects
      of the primary temporary differences giving rise to the Company's deferred
      tax asset are as follows as of June 30, 1999:

           Deferred compensation                                   $   332,000
           Net operating loss carryforward                           1,004,000
           Deferred tax asset                                        1,336,000
           Valuation allowance                                     $(1,336,000)

           Net deferred tax asset                                  $     __0__
                                                                   ============

4.    Stockholder's Equity:

      In December, 1997, the Company commenced the public offering of up to
      400,000 Units of newly-issued securities for an aggregate of $4,000,000.
      Each Unit consists of one share of common stock, $0.01 par value, and .25
      Charitable Benefit Warrants. Each whole Charitable Benefit Warrant
      entitles the holder to purchase one share of the Common Stock at a price
      of $20.00 per share. The Company has received proceeds of $344,200 through
      June 30, 1999. The offering, which is currently suspended, will be
      continued until all securities have been sold or until December 10, 1999,
      unless sooner terminated or extended. If the proceeds from the offering
      and the Q-Med AB investment, described below in Note 6, prove to be
      insufficient, then the Company would be required to obtain additional
      funds through equity or debt financing, strategic alliances with corporate
      partners, or through other sources.

      There can be no assurance that the Company will be successful in obtaining
      the required financing. Under current circumstances, the Company's ability
      to continue as a going concern depends upon either completing the Q-Med
      transaction or obtaining additional funds through other sources.

     Offering costs of $124,631 have been offset against the proceeds of the
     offering through June 30, 1999.


                                       6
<PAGE>


5.    Related Party Transactions:

      The Chairman and Chief Executive Officer and the President of the Company
      have agreed to extend the Company financing in the form of bridge loans.
      Interest on the bridge loans from officers is at 8% but can be reset
      annually, at the election of either party, to the prime rate in effect on
      January 1 of any given year, plus 3%. Under these agreements, the Company
      borrowed a total of $415,000, which was still outstanding at June 30, 1999
      and is due on demand. These officers have no commitment to lend additional
      funds in the future.

6.    Subsequent Events:

      Under the agreement in principle executed on April 16, 1999, Q-Med AB, a
      Swedish company whose headquarters are in Uppsala, Sweden, agreed to
      purchase not less than three million shares of the Company's common stock,
      in exchange for

      o   $6,000,000 in cash,

      o   a royalty-free license to Q-Med's non-animal, stabilized hyaluronic
          acid  technology for use as an encapsulation material for
          transplantable islets, and
      o   the redemption of up to $571,670 of the Company's Convertible
          Unsecured Notes which note holders elect not to convert in August2001.

      The original transaction was contingent on the execution of a mutually
      satisfactory stock purchase agreement and the successful completion of
      additional financing by Q-Med, on or before July 15, 1999. Q-Med was
      unable to complete its additional financing by July 15, 1999, and,
      accordingly, the Company and Q-Med are discussing an amendment to the
      agreement in principle.

      Q-Med advanced $300,000 on April 16, 1999, upon execution of the original
      agreement in principle, which was converted into 150,000 newly-issued
      shares of Ixion common stock on August 2, 1999. Q-Med has agreed to
      advance at least an additional $75,000 to the Company on August 15, 1999.

      On July 12, 1999, as a result of the pending Q-Med transaction, the Board
      of Directors of the Company approved a retroactive reduction in the
      offering price of the Company's suspended public offering (see Note 4)
      from $10.00 per Unit to $4.00 per Unit. The Board also approved a
      concomitant adjustment in the exercise price for outstanding Charitable
      Benefit Warrants (from $20/share to $8/share) and an increase in the
      number of shares purchasable upon exercise of those warrants from 8,605
      shares to 21,513 shares. This action by the board will result in the
      issuance of a total of 51,630 shares (approximately 2% of the current
      outstanding) to purchasers in the public offering for no additional
      consideration, and a reduction in the maximum potential aggregate offering
      amount from $4,000,000 to $1,600,000. In order to change the terms of the
      public offering, the Company will be required to file a post-effective
      amendment to the current registration statement.

      On July 12, 1999, the Company granted ten-year options under the 1994
      Stock Option Plan to purchase 73,000 shares of Common Stock at an exercise
      price of $4.00 per share. Stock options are exercisable only if vested.
      15,000 of such options, granted to members of the Scientific Advisory
      Board, vest over one year, the remainder vest over five years. In
      addition, the Company has determined that it will cancel and reissue
      82,400 options previously granted at exercise prices ranging from $6.00
      per share to $10.00 per share. There will be no change in the vesting
      period for reissued options.

                                       7

<PAGE>


Item 2. Management's Discussion and Analysis of Financial Condition and Results
of Operations or Plan of Operations.

           The following discussion and analysis should be read in conjunction
with the Condensed Financial Statements and the related Notes thereto included
elsewhere in this report. This report contains forward-looking statements that
involve risks and uncertainties. Our actual results may differ significantly
from the results discussed in the forward-looking statements. These and
additional risk factors are identified in our annual report to the Securities
and Exchange Commission filed on forms 10-KSB and in other SEC filings.

Overview

            Ixion is a development stage, biotechnology company. We are in the
development stage because we are devoting substantially all of our efforts to
establishing our business, and our planned principal operations have not
commenced.

            Since we were founded in March of 1993, we have principally been
doing research and development, securing patent protection, and raising capital.
We have not received any revenues from the sale of products. In June 1998, we
reached an agreement in principle with the University of Florida Diagnostic
Referral Laboratories for them to provide a service to physicians using our
molecular diagnostic test, the XEntrIx TM Oxalobacter formigenes Monitor. We
have received no revenue to date under this agreement. Provided the Diagnostic
Referral Laboratories markets the service and provided doctors accept the test
as useful, we may receive revenue from this test during 1999. However we do not
expect any of our other product candidates to be commercially available for at
least several years. From inception through June 30, 1999, we incurred
cumulative losses of $3,383,653. These losses were due primarily to expenditures
on general and administrative activities, research and development, patent
preparation and prosecution, and interest charges.

            We expect to continue to incur substantial research and development
costs resulting from

        o  ongoing research and development programs,

        o  manufacturing of products for use in clinical trials and preclinical
and clinical testing of our products.

            We also expect that general and administrative costs, including

        o  amortization of patents,
        o  additional administrative personnel;
        o  legal and regulatory costs necessary to support preclinical
development and clinical trials,
        o   SEC reporting costs, and
        o   the creation of a marketing and sales organization, if warranted,

will increase in the future, assuming we can finance the increased requirements.
Accordingly, we expect to incur operating losses for the foreseeable future.

            We have only a limited operating history upon which you can base an
evaluation of our prospects. You should consider the risks, expenses, and
difficulties encountered by companies at an early stage of development when
evaluating our prospects. To address these risks, we must, among other things,

        o   successfully develop and commercialize our products,
        o   secure all necessary proprietary rights,
        o   respond to competitive developments, and
        o   continue to attract, retain and motivate qualified persons.


                                       8
<PAGE>

            There can be no assurance that we will be successful in addressing
these risks.

            Our operating expenses will depend on several factors, including the
level of research and development expenses and our success in raising capital.
Research and development expenses will depend on the progress and results of our
product development efforts, which we cannot predict. We may sometimes be able
to control the timing of development expenses in part by accelerating or
decelerating preclinical testing and clinical trial activities. As a result of
these factors, we believe that period-to-period comparisons in the future are
not necessarily meaningful and you should not rely on them as an indication of
future performance. Due to all of the foregoing factors, it is possible that our
operating results will be below the expectations of market analysts, if any, and
investors. In such event, the prevailing market price, if any, of our common
stock would likely be materially adversely affected.

Results of Operations

Three Months Ended June 30, 1999 and 1998

            Total revenues decreased by 15% from $1,364 for the second quarter
of 1998 to $1,165 for the second quarter of 1999 mainly as a result of the
decline in other income resulting from a reduction in consulting provided by us.
We expect income to increase in 1999 as a result of the award of a research
contract under the Small Business Technology Transfer ("STTR") Program which
will provide approximately $40,000 of income in 1999.

            Operating, general and administrative expenses increased 9% from
$80,909 for the second quarter of 1998 to $88,085 for the equivalent period of
1999. These increased expenses reflect increased directors fees resulting from
an increased number of directors, increased travel expenses, and increases in
various other administrative categories, offset, to some degree, by a decline in
salaries and advertising expense for the second quarter of 1999 compared to the
second quarter of 1998. The Company expects its general and administrative
expense to increase during the remainder of 1999 as a result of an increase in
the scale of operations which may result from the pending Q-Med transaction, an
increase in amortization of capitalized patent costs as new patents are issued,
and continued amortization of capitalized debt issue costs.

             Research and development expenditures consist primarily of
payroll-related expenses of research and development personnel, laboratory
supplies, animal supplies, laboratory rent and associated utilities,
depreciation on laboratory equipment, development activities, payments for
sponsored research, and payments to scientific and regulatory consultants.
Research and development expenses increased 28% from $101,310 for the second
quarter of 1998 to $129,514 for the second quarter of 1999, mainly due to an
increase in laboratory personnel, increased rent, utilities, and interest
charges on the purchase of lab equipment and on deferred fees and salaries. The
Company's research and development expenses could increase during the remainder
of 1999 as a result of an increase in the scale of operations which may result
from the pending Q-Med transaction and as a result of the receipt of the STTR
grant referred to above.

             Interest expense increased 33% from $28,204 for the second quarter
of 1998 to $37,559 for the second quarter of 1999 due primarily to interest on
bridge loans from officers, and the compounding of interest on deferred fees and
salaries, including deferred interest, payable to related parties. Interest
expense will continue to increase during 1999, as a result of the continued
compounding of interest on deferred fees and salaries accounts and loans we have
received and expect to receive.

Six Months Ended June 30, 1999 and 1998

            Total revenues decreased by 33% from $2,491 in the first half of
1998 to $1,658 in the first half of 1999 mainly as a result of the decline in
other income resulting from a reduction in consulting provided by us. We expect
income to increase in 1999 as a result of the award of a research contract under
the Small Business Technology Transfer ("STTR") Program which will provide
approximately $40,000 of income in 1999.


                                       9
<PAGE>

            Operating, general and administrative expenses decreased 10% from
$199,793 in the first half of 1998 to $178,819 in the equivalent period of 1999.
These decreased expenses reflect decreased personnel during the first quarter,
decreased legal fees, and decreased advertising expenses in the first half of
1999 compared to the first half of 1998. The Company's general and
administrative expense should increase during the remainder of 1999 as a result
of an increase in personnel and an increase in the scale of operations which may
result from the pending Q-Med transaction, an increase in amortization of
capitalized patent costs as new patents are issued, and continued amortization
of capitalized debt issue costs.

             Research and development expenditures consist primarily of
payroll-related expenses of research and development personnel, laboratory and
animal supplies, laboratory rent and associated utilities, depreciation on
laboratory equipment, development activities, payments for sponsored research,
and payments to scientific and regulatory consultants. Research and development
expenses increased 26% from $188,872 in the first half of 1998 to $238,166 in
the first half of 1999, mainly due to an increase in laboratory personnel, rent,
utilities, interest charges on the purchase of lab equipment and on deferred
fees and salaries, and scientific advisors fees; offset somewhat by a reduction
in preclinical expenses and lab supplies. The Company's research and development
expenses could increase during the remainder of 1999 as a result of an increase
in the scale of operations which may result from the pending Q-Med transaction
and as a result of the receipt of the STTR grant referred to above.

             Interest expense increased 32% from $56,594 in the first half of
1998 to $74,729 in the first half of 1999 due primarily to interest on bridge
loans from officers, and the compounding of interest on deferred fees and
salaries, including deferred interest, payable to related parties. Interest
expense will continue to increase during 1999, as a result of the continued
compounding of interest on deferred fees and salaries and loans we have received
and expect to receive.

Liquidity and Capital Resources

            In December, 1997, we commenced the public offering of 400,000 Units
of newly issued securities, for an aggregate of $4,000,000. Each Unit consists
of one share of common stock and .1/4 of a Charitable Benefit Warrant. Each
whole Charitable Benefit Warrant entitles someone to purchase one share of
common stock at a price of $20.00 per share. Ixion is directly (except in
Florida where sales must be made through a broker) making the offering selected
states, primarily over the Internet. There is no minimum number of Units to be
sold in the offering, and all funds received have gone and will go immediately
to us. On December 10, 1998, we extended the offering through the earliest of:

        o   the sale of all Units,
        o   December 10, 1999, or
        o   the date we decide to close the offering.

            In connection with the proposed transaction with Q-Med AB, described
below, we temporarily suspended the offering. On July 12, 1999, in consequence
of the pending Q-Med transaction, the Board of Directors approved a retroactive
reduction in the offering price of the Company's suspended public offering from
$10.00 per Unit to $4.00 per Unit. The Board also approved a concomitant
adjustment in the exercise price for outstanding Charitable Benefit Warrants
(from $20/share to $8/share) and an increase in the number of shares purchasable
upon exercise of those warrants from 8,605 shares to 21,513 shares. This action
will result in the issuance of a total of 51,630 shares (approximately 2% of the
current outstanding) to purchasers in the public offering for no additional
consideration.

            In order to change the terms of the public offering, the Company
will be required to file a post-effective amendment to the current registration
statement. The reduction in the offering price will reduce the aggregate maximum
potential amount to be raised from $4,000,000 to $1,600,000.

            In February, 1999, we received notice that the NIH had awarded us a
$100,000 Phase I grant under the Small Business Technology Transfer Program for
research in our oxalate technology. The effective date of the grant is June 15,
1999 and as of June 30, 1999 we have accrued $3,212 to be applied toward the
grant. These funds are available and were drawn on beginning in July, 1999. We


                                       10
<PAGE>

will subcontract approximately $60,000 to the University of California, Irvine,
but the remaining $40,000 will be available during 1999 to support oxalate
research at Ixion. We have several other grant applications pending.

            During 1998 and the first quarter of 1999, our development
activities were funded primarily by the proceeds from the offering and bridge
loans from the Chairman and Chief Executive Officer and the President.
Operations during the second quarter of 1999 were funded primarily from funds
advanced by Q-med. The bridge loans total $415,000 at June 30, 1999. Interest on
the bridge loans from officers is currently at 8% but can be reset annually, at
the election of either party, to the prime rate in effect on January 1 of any
given year, plus 3%. We have no agreement with the officers to advance further
funds, however, the officers have continued to fund operating requirements
voluntarily to meet working capital needs. Although additional bridge loans may
not be necessary during the remainder of 1999 because of the pending Q-Med
transaction, we can not assure you that, should such loans be necessary, the
officers will continue to voluntarily fund them. We do not have any bank
financing arrangements. Our long-term indebtedness consists primarily of
deferred fees and salaries payable to related individuals and our unsecured
convertible notes.

            At June 30, 1999, we had $81,016 in cash and cash equivalents. Until
required for operations, our policy is to invest any excess cash reserves in
bank deposits, money market funds, certificates of deposit, commercial paper,
corporate notes, U.S. government instruments and other investment-grade quality
instruments. On April 20, 1999, we received $300,000 in the form of a
convertible loan from Q-Med pursuant to the Q-Med transaction described below.
On August 2, 1999, the loan was converted into 150,000 shares of restricted
Ixion common stock.

            On January 1, 1996, we purchased laboratory equipment pursuant to a
chattel mortgage agreement in the amount of $32,309. The agreement calls for
monthly payments of $897, commencing August 1, 1996. At June 30, 1999, one
payment of $897 in principal remains outstanding under this agreement.

            In connection with a sponsored research agreement with Genetics
Institute, Inc. which was concluded during 1997, some patent-related expenses
were reimbursed by Genetics Institute. We may be contractually obligated to
repay these reimbursed expenses in installments over a 36 month period upon a
notice to or by Genetics Institute to the effect that their option to negotiate
for a license to our technology, contained in the sponsored research agreement
has expired. We have not given nor received such notice, and, accordingly,
reimbursement has not commenced. We have accrued $42,317 as a long term
liability pending final notice under the agreement.

            Through June 30, 1999, we have paid offering-related expenses of
$124,631 which have been applied against the proceeds of the public offering. We
expect further offering-related expenses to be modest.

            On October 8, 1998, upon the expiration of our lease at the
Biotechnology Development Institute, we moved to comparable rental facilities
across the street from our former location. The new lease is for increased space
and rent and for a three-year term, with two one-year renewal options. We expect
that annual payments under the new lease (including repayment of funds provided
by lessor for tenant improvements and an emergency generator) will be
approximately $92,000 per year. We will continue to have access, as a graduate
affiliate, to the Biotechnology Development Institute's specialized facilities,
centralized equipment, and core laboratories. Relocation has not materially
affected our research and development operations; however, we incurred
relocation expenses and have been obliged to purchase or lease laboratory and
office furnishings and equipment in the amount of approximately $100,000.

            We have incurred negative cash flows from operations since our
inception. We have spent and expect to continue to spend, substantial funds to
complete our planned product development efforts, commence clinical trials, and
diversify our technology. Our future capital requirements and the adequacy of
available funds will depend on numerous factors, including

        o  the completion of a Q-Med transaction described below
        o  the success of the continuing public offering of our securities (in
the event of a failure of the Q-Med transaction),


                                       11
<PAGE>


        o  the successful commercialization of our medicinal food product, a
probiotic product, the XEntrIx (TM) Oxalobacter formigenes Monitor (our new
diagnostic test) and IxC1-62/47 (our lead therapeutic compound),
        o  progress in our product development efforts,
        o  the magnitude and scope of development efforts,
        o  progress with preclinical studies and clinical trials,
        o  the cost of contract manufacturing and research organizations,
        o  cost of filing, prosecuting, defending and enforcing patent claims
and other intellectual property rights, o competing technological and market
developments, and o the development of strategic alliances for the development
and marketing of our products.

The Q-Med Transaction

            On April 16, 1999, we reached an agreement in principle with Q-Med
AB, a biotechnology company based in Uppsala, Sweden. Under the original
agreement, Q-Med agreed to purchase not less than three million shares of Ixion
common stock, in exchange for

        o   $6,000,000 in cash,
        o   a royalty-free license to Q-Med's non-animal, stabilized hyaluronic
acid  technology for use as an encapsulation material for our transplantable
islets, and
        o   the  redemption of up to $571,670 of our Convertible Unsecured
Notes which note holders elect not to convert in August 2001.

            Q-Med, a growing, profitable Swedish company, develops, manufactures
and sells natural, specialized medical implants. All of Q-Med(180)s products are
constructed using a proprietary form of non-animal, stabilized hyaluronic acid.
Hyaluronic acid is a natural polysaccharide, first isolated in 1934. Its main
function in the body is to lubricate moveable parts like joints and muscles and
to transport substances to and within cells. The majority of Q-Med's revenues
are accounted for by Restylane(R) for the filling out of lips, facial wrinkles,
and facial folds.

            The original transaction was contingent on the execution of a
mutually satisfactory stock purchase agreement and the successful completion of
additional financing by Q-Med, on or before July 15, 1999. Q-Med was unable to
complete its additional financing by July 15, 1999, and, accordingly, the
Company and Q-Med are discussing an amendment to the agreement in principle.

            Q-Med advanced $300,000 on April 16, 1999, upon execution of the
original agreement in principle, which was converted into 150,000 newly-issued
shares of Ixion common stock on August 2, 1999. Q-Med has agreed to advance an
additional $75,000 to the Company on August 15, 1999.

            We must reach an amended agreement with Q-Med to meet our planned
operating requirements through December 31, 1999. We cannot assure you that we
will be able to reach agreement with Q-Med on satisfactory terms, or at all.
Failing that, we must successfully complete the suspended public offering.
Shortfalls in the proceeds of the public offering to date have forced a
curtailment in our operations to adjust to reduced resources. In the event our
plans change or our assumptions change or prove to be inaccurate or we fail to
close a satisfactory Q-Med transaction or the proceeds of the offering continue
to be insufficient to fund operations at the planned level (due to further
unanticipated expenses, delays, problems or otherwise), we will require
additional financing. We will be required to obtain additional funds in any
event through equity or debt financing, strategic alliances with corporate
partners and others, mergers or the sale of substantially all our assets, or
through other sources in order to bring our products through regulatory approval
to commercialization. The terms and prices of any equity or debt financings or
corporate combination may be significantly more favorable to new investors than
those of the Units sold in the offering, resulting in significant dilution to
current investors. We do not have any material committed sources of additional
financing. We can not assure you that additional funding, consolidation, or
alliance, if necessary, will be available on acceptable terms, if at all. If



                                       12
<PAGE>


adequate funds are not available, we may be required to further delay,
scale-back, or eliminate certain aspects of our operations or attempt to obtain
funds through arrangements with collaborative partners or others that may
require us to relinquish rights to certain of our technologies, product
candidates, products, or potential markets. If adequate funds are not available,
our business, financial condition, and results of operations will be materially
and adversely affected.

Product Research and Development Plan

          Our plan of operation for the remainder of 1999 consists primarily of
research and development and related activities, resources permitting,
including:

          o  further research into the biology of islet and islet stem cell
growth and differentiation, aimed at developing cell lines of functioning
islets for transplantation into diabetic patients;
          o   further research into identifying and characterizing novel growth
factors associated with islets to discover factors important in islet cell
differentiation and possible regulation of diabetes and to identify stem cell
markers to which we hope to produce monoclonal antibodies useful in stem cell
isolation
          o research into differential gene expression studies on differentiated
islet cells;
          o further research into encapsulation materials for transplantation of
islets;
          o development of a medicinal food product not requiring regulatory
approval;
          o further preclinical development of a quantitative version of our
molecular diagnostic test, the XEntrIx(TM)Oxalobacter formigenes Monitor,
          o further preclinical development of our oxalate therapeutic compound,
 IxC1-62/47;
          o continuing the prosecution and filing of patent applications; and
          o hiring additional employees.

            Our actual research and development and related activities may vary
significantly from current plans depending on numerous factors, including
changes in the costs of such activities from current estimates, the results of
our research and development programs, the results of clinical studies, the
timing of regulatory submissions, technological advances, determinations as to
commercial potential, the status of competitive products, and, most important,
our success in raising capital. The focus and direction of our operations will
also be dependent upon the establishment of collaborative arrangements with
other companies, and other factors.

            We can not assure you that we will be able to commercialize our
technologies or that profitability will ever be achieved. We expect that our
operating results will fluctuate significantly from quarter to quarter in the
future and will depend on a number of factors, most of which are outside our
control.

Year 2000 Compliance

            Many computer systems and computer chips embedded in equipment are
unable to tell the difference between the year 1900 and the year 2000. This is
known as the Year 2000 issue. Many businesses are at risk for possible
miscalculations or systems failures as a result of their computers, software, or
equipment's not being Year 2000 compliant.

            Our assessment of Year 2000 compliance issues is substantially
complete.

            Software and Computers. Our computers all run Windows operating
systems which are or will be Year 2000 compliant according to our tests and
information received from Microsoft. We have been assured by the vendors that
our office applications programs are Year 2000 compliant. We have been also been
assured by the vendor that our finance and accounting software, our only
mission-critical software, is Year 2000 compliant.

            Equipment. Most of our laboratory equipment does not use a computer
or embedded chip. Our policy is that all new equipment that we purchase must be
Year 2000 compliant. Our assessment of our laboratory equipment is complete, and
all essential equipment is compliant.

                                       13
<PAGE>

            With respect to equipment made available to us as a result of our
affiliation with the Biotechnology Development Institute, we have requested a
statement of compliance.

            Suppliers. We are contacting key suppliers regarding their Year 2000
compliance in order to determine if there might be any effect on our operations.
In general, our suppliers (primarily scientific reagent and disposable equipment
vendors), have developed or are in the process of developing plans to address
Year 2000 issues. We will continue to monitor and evaluate the progress of our
suppliers.

            In general our review of the potential consequences of Year 2000
compliance issues on us leads us to believe that those issues will prove to be
immaterial to our business, operations, and financial condition. Accordingly, we
do not have contingency plans and have no plans to develop any unless our
further assessment indicates one is necessary. No material expenses have been
incurred to date, and none are anticipated.



                                       14
<PAGE>


Part II - Other Information

Item 2.  Changes in Securities and Use of Proceeds

            In 1997, the Company registered 400,000 newly-issued Units of its
securities for direct sale on Form SB-2 at a price of $10.00 per Unit. The
registration statement, Commission Registration No. 333-334765, was declared
effective on December 10, 1997 and Post-Effective Amendment No. 1 was declared
effective on March 19, 1998. On December 10, 1998, the Company extended the
offering, and thereafter filed Post-Effective Amendment No. 2 to reduce the
number of Units being registered to 150,000 Units (including the Units already
sold), for an aggregate offering price of $1,500,000. Each Unit consists of one
share of common stock, $0.01 par value, and .25 Charitable Benefit Warrant.
There is no minimum number of Units to be sold in the offering, and all funds
received will go immediately to the Company. The offering has not terminated and
is not scheduled to terminate until the earliest of: the sale of all Units,
December 10, 1999, or the date on which the Company decides to close the
offering; however, the offering is currently suspended pending the completion of
the Q-Med transaction described elsewhere in this report. The securities are
being sold directly by the Company (except when sales are to Florida residents,
in which case sales must be made through Unified Management Corporation, a
Florida-registered broker dealer). See Liquidity and Capital Resources, above,
for proposed changes in the offering.

            As of June 30, 1999, a total of 34,420 Units at an aggregate price
of $344,200 have been sold. From the effective date of the offering to June 30,
1999, $200 in expenses and $1,854 in commissions have been paid to Unified
Management Company as broker and there have been no finders' fees. Other
offering related expenses through June 30, 1998, amounted to $122,577, all of
which have been offset against proceeds. No payments were made to directors,
officers, general partners of the Company, or to their associates in connection
with the offering.

            Net offering proceeds as of June 30, 1999 amounted to $219,569. The
net proceeds were used entirely to fund the operations of the Company as
reflected in the financial statements included elsewhere in this report. The use
of proceeds still to be received from the offering is not expected to vary
materially from the use of proceeds described in the amended registration
statement.

Item 4.  Submission of Matters to a Vote of Security Holders

            The Company's annual meeting was held on June 11, 1999. The
shareholders of the Company elected the following directors of the Company to
serve until the next annual meeting.

Weaver H. Gaines
David C. Peck
David M. Margulies
Vincent P. Mihalik
Karl-E. Arfors

            The shareholders approved an amendment to the Company's certificate
of incorporation to increase the Company's authorized number of shares of common
stock from 4,000,000 shares to 20,000,000 shares and to authorize up to
1,000,000 shares of a new class of preferred stock. The total number of shares
cast "For," cast "Against," and "Abstentions" are set forth below.

        Votes For               Votes Against                       Abstentions
        2,043,694                           0                            10,000

            The shareholders approved an amendment to the 1994 Board Retainer
Plan which increased the total number of shares which may be issued and
outstanding to 250,000 (including, 99,050 previously issued). The amended plan
also limited the total number of shares reserved for issuance to 250,000 by
bringing issuances to employees and consultants under the 250,000 cap. The total
number of shares cast "For," cast "Against," and "Abstentions" are set forth
below.



                                       15
<PAGE>

       Votes For               Votes Against                       Abstentions
       2,043,694                       0                                10,000

            Finally, the shareholders of the Company ratified the selection of
PricewaterhouseCoopers LLP as independent accountants for its fiscal year ended
December 31, 1999, and the total number of shares cast "For," cast "Against" and
"Abstentions" are set forth below:

       Votes For               Votes Against                       Abstentions
       2,053,694                       0                                   0

Item 5.  Other Information

            On July 12, 1999, Bengt (W067)gerup, Ph.D., majority stockholder in
Q-Med and its former Managing Director, and Thomas Stagnaro, Chairman of US
Biomaterials, were elected to the Ixion board of directors.

            The Q-Med transaction previously reported on Form 8-K has been
modified as described above in Part I, Item 2.

Item 6.  Exhibits and Reports on Form 8-K

            (a)     Exhibits
<TABLE>
<CAPTION>
<S>            <C>                                                                         <C>

Exhibit                 Description

(2)         Plan of Acquisition, Reorganization, Arrangement,
                        Liquidation or Succession                                                None
*(3.5)      Certificate of Amendment of Certificate of Incorporation, dated June 11, 1999
*(3.6)                Certificate of Incorporation, as amended and restated
   (4)                Instruments defining the Rights of Security Holders

*(10.39)    Agreement in Principle dated April 16, 1999, with Q-Med AB

*(10.40)    1994 Board Retainer Plan, as amended.

 (11)       Statement re: Computation of Per Share Earnings                                      None

 (15)       Letter re: Unaudited Interim Financial Information                                   None

 (18)       Letter re: Change in Accounting Principles                                           None

 (19)       Report Furnished to Security Holders                                                 None

(22)        Published Report re: Matters Submitted to Vote of
                      Security Holders                                                           None

(23)        Consents of Experts and Counsel                                                      None

(24)        Power of Attorney                                                                    None



                                       16
<PAGE>

*(27)       Financial Data Schedule

 (99)       Additional Exhibits                                                                  None
</TABLE>


- -----------
*Filed herewith

            (b)     Reports on Form 8-K

            The Company filed a Form 8-K on April 30, 1999 in connection with
the execution of an agreement in principal with Q-Med AB, pursuant to which
Q-Med could acquire up to 50% of the common stock of the Company which could
lead to a change in control of the Company.

- - ----------

                                   Signatures

            In accordance with the requirements of the Exchange Act, the
registrant caused this report to be signed on its behalf by the undersigned,
thereunto duly authorized.

                                   Ixion Biotechnology, Inc.

Dated: August 16 1999               By: /s/ Weaver H. Gaines
                                      -----------------------------------------
                                       Weaver H. Gaines
                                       Chairman and Chief  Executive Officer

Dated: August 16, 1999              By: /s/ David C. Peck
                                        ---------------------------------------
                                        David C. Peck
                                        President and Chief Financial Officer
                                       (Principal Financial Officer

Dated: August 16, 1999              By: /s/ Kimberly A. Ramsey
                                        ---------------------------------------
                                        Kimberly A. Ramsey
                                        Vice President and Controller
                                       (Principal Accounting Officer)

          Exhibit Index
<TABLE>
<CAPTION>
<S>           <C>                                                                    <C>

Exhibit         Description                                                             Page

(2)          Plan of Acquisition, Reorganization, Arrangement,
                Liquidation or Succession                                               None

*(3.5)       Certificate of Amendment of Certificate of Incorporation,
                dated June 11, 1999

*(3.6)       Certificate of Incorporation, as amended and restated

(4)          Instruments defining the Rights of Security Holders                        None

*(10.39)     Agreement in Principle dated April 16, 1999, with Q-Med AB

*(10.40)     1994 Board Retainer Plan, as amended.


                                       17
<PAGE>

(11)         Statement re: Computation of Per Share Earnings                            None

(15)         Letter re: Unaudited Interim Financial Information                         None

(18)         Letter re: Change in Accounting Principles                                 None

(19)         Report Furnished to Security Holders                                       None

(23)         Published Report re: Matters Submitted to Vote of
                Security Holders                                                        None

(23)         Consents of Experts and Counsel                                            None

(24)         Power of Attorney                                                          None

*(27)        Financial Data Schedule

(99)         Additional Exhibits                                                        None


- --------------
*Filed herewith
</TABLE>


                            CERTIFICATE OF AMENDMENT

                         OF CERTIFICATE OF INCORPORATION

            Ixion Biotechnology, Inc., a corporation organized and existing
under and by virtue of the General Corporation Law of the State of Delaware (the
"Company") through the Chairman of its Board of Directors certifies in
accordance with Section 103 of the General Corporation Law:

            1.  The name of the Company is Ixion Biotechnology, Inc.

            2. The date on which the Certificate of Incorporation of the Company
was originally filed with the Secretary of State of the State of Delaware is
March 25, 1993.

            3. That the Board of Directors of the Company, acting in accordance
with the provisions of Section 141 and 242 of the General Corporation Law,
adopted a resolutions amending its Certificate of Incorporation as follows

            RESOLVED, that the certificate of incorporation be amended by
deleting the Article numbered FOURTH and replacing in its entirety as follows:

                    "FOURTH: The total number of shares of stock
                     which the corporation shall have authority to issue is
                     1,000,000 shares of Preferred Stock with a par value of
                     $0.01 per share and 20,000,000 shares of Common Stock,
                     par value $0.01 per share. The Board of Directors, by
                     adoption of an authorizing resolution, may cause
                     Preferred Stock to be issued from time to time in one or
                     more series. The Board of Directors, by adoption of an
                     authorizing resolution, may, with regard to the shares
                     of any series of Preferred Stock:

             (1)         Fix the distinctive serial designation of the shares;

             (2)         Fix the dividend rate, if any;

             (3)         Fix the date from which dividends on shares issued
before the date for payment of the first dividend shall be cumulative, if any;

             (4)         Fix the redemption price and terms of redemption, if
any;

             (5) Fix the amounts payable per share in the event of dissolution
or liquidation of the Company, if any;

             (6) Fix the terms and amounts of any sinking fund to be used for
the purchase or redemption of shares, if any;

             (7) Fix the terms and conditions under which the shares may be
converted, if any;

             (8) Provide whether such shares shall be non-voting, or shall have
full or limited voting rights, and the rights, if any, of such shares to vote
as a class on some or all matters on which such shares may be entitled to vote;
and

             (9) Fix such other preferences, qualifications, limitations,
restrictions, and special or relative rights not required by law."

            4. Thereafter, pursuant to a resolution of the Board of Directors,
this Certificate of Amendment was submitted to the stockholders of the Company
for their approval, and was duly adopted in accordance with the provisions of
Section 242 of the General Corporation Law of the State of Delaware.

            5. That the capital of the Company shall not be reduced under or by
reason of said amendment.

IN WITNESS WHEREOF, the Company has executed this certificate and caused its
corporate seal to be affixed hereto this 11th day of June, 1999.


                              Ixion Biotechnology, Inc.

                              By /s/ Weaver H. Gaines
                              Weaver H. Gaines, Chairman of the Board

[Corporate Seal]

Attest:    /s/ Ted Snow
          Ted Snow, Assistant Secretary

STATE OF FLORIDA   )
COUNTY OF ALACHUA  )

            On this 11th day of June, 1999, before me the undersigned, a Notary
Public for the State of Florida, appeared Weaver H. Gaines and Mary Trew (known
to me), the Chairman of the Board and Secretary of the Company that executed the
forgoing certificate of amendment of certificate of incorporation, and
acknowledged to me that the forgoing are their acts and deeds and the act and
deed of the Company and that the facts stated therein are true.

            IN WITNESS WHEREOF, I have hereunto set my hand and affixed my
official seal the day and year in this certificate above written.

                              Gwen Thompson

                              Notary Public for the State of Florida

(Notarial Seal)


                                    RESTATED

                          CERTIFICATE OF INCORPORATION

                                       OF

                            IXION BIOTECHNOLOGY, INC.

                           (As amended July 19, 1999)

                                   ----------

            FIRST: The name of the corporation (hereinafter called the
"corporation") is  IXION BIOTECHNOLOGY, INC.

            SECOND: The address, including street, number, city, and county, of
the registered office of the corporation in the State of Delaware is 32
Loockerman Square, Suite L-100, City of Dover 19901, County of Kent; and the
name of the registered agent of the corporation in the State of Delaware at such
address is The Prentice-Hall Corporation System, Inc.

            THIRD: The purpose of the corporation is to engage in any lawful
act or activity for which corporations may be organized under the General
Corporation Law of the State of Delaware.

            FOURTH: The total number of shares of stock which the corporation
shall have authority to issue is 1,000,000 shares of Preferred Stock with a par
value of $0.01 per share and 20,000,000 shares of Common Stock, par value $0.01
per share. The Board of Directors, by adoption of an authorizing resolution, may
cause Preferred Stock to be issued from time to time in one or more series. The
Board of Directors, by adoption of an authorizing resolution, may, with regard
to the shares of any series of Preferred Stock:

            (1) the distinctive serial designation of the shares;
            (2) Fix the dividend rate, if any;
            (3) Fix the date from which dividends on shares issued before the
                date for payment of the first dividend shall be cumulative,
                if any;
            (4) Fix the redemption price and terms of redemption, if any;
            (5) Fix the amounts payable per share in the event of dissolution
or liquidation of the Company, if any;
            (6) Fix the terms and amounts of any sinking fund to be used for
                the purchase or redemption of shares, if any;
            (7) Fix the terms and conditions under which the shares may be
converted, if any;
            (8) Provide whether such shares shall be non-voting, or shall have
full or limited voting rights, and the rights, if any, of such shares to vote
as a class on some or all matters on which such shares may be entitled to vote;
and
            (9) Fix such other preferences, qualifications, limitations,
restrictions, and special or relative rights not required by law."


<PAGE>


            FIFTH: The name and the mailing address of the incorporator are as
follows:
            NAME                                     MAILING ADDRESS
            Athena Amaxas                            15 Columbus Circle
                                                     New York, N.Y. 10023-7773

            SIXTH: The corporation is to have perpetual existence.

            SEVENTH: Whenever a compromise or arrangement is proposed between
this corporation and its creditors or any class of them and/or between this
corporation and its stockholders or any class of them, any court of equitable
jurisdiction within the State of Delaware may, on the application in a summary
way of this corporation or of any creditor or stockholder thereof or on the
application of any receiver or receivers appointed for this corporation under
the provisions of ' 291 of Title 8 of the Delaware Code or on the application of
trustees in dissolution or of any receiver or receivers appointed for this
corporation under the provisions of ' 279 of Title 8 of the Delaware Code order
a meeting of the creditors or class of creditors, and/or of the stockholders or
class of stockholders of this corporation, as the case may be, to be summoned in
such manner as the said court directs. If a majority in number representing
three fourths in value of the creditors or class of creditors, and/or of the
stockholders or class of stockholders of this corporation, as the case may be,
agree to any compromise or arrangement and to any reorganization of this
corporation as consequence of such compromise or arrangement, the said
compromise or arrangement and the said reorganization shall, if sanctioned by
the court to which the said application has been made, be binding on all the
creditors or class of creditors, and/or on all the stockholders or class of
stockholders, of this corporation, as the case may be, and also on this
corporation.

            EIGHTH: For the management of the business and for the conduct of
the affairs of the corporation, and in further definition, limitation, and
regulation of the powers of the corporation and of its directors and of its
stockholders or any class thereof, as the case may be, it is further provided:

                        1. The management of the business and the conduct of the
            affairs of the corporation shall be vested in its Board of
            Directors. The number of directors which shall constitute the whole
            Board of Directors shall be fixed by, or in the manner provided in,
            the Bylaws. The phrase "whole Board" and the phrase "total number of
            directors" shall be deemed to have the same meaning, to wit, the
            total number of directors which the corporation would have if there
            were no vacancies. No election of directors need be by written
            ballot.

                        2. After the original or other Bylaws of the corporation
            have been adopted, amended, or repealed, as the case may be, in
            accordance with the provisions of ' 109 of the General Corporation
            Law of the State of Delaware, and, after the corporation has
            received any payment for any of its stock, the power to adopt,
            amend, or repeal the Bylaws of the corporation may be exercised by
            the Board of Directors of the corporation; provided, however, that
            any provision for the classification of directors of the corporation
            for staggered terms pursuant to the provisions of subsection (d) of
            ' 141 of the General Corporation Law of the State of Delaware shall
            be set forth in an initial Bylaw or in a Bylaw adopted by the
            stockholders entitled to vote of the corporation unless provisions
            for such classification shall be set forth in this certificate of
            incorporation.

                        3. Whenever the corporation shall be authorized to issue
            only one class of stock, each outstanding share shall entitle the
            holder thereof to notice of, and the right to vote at, any meeting
            of stockholders. Whenever the corporation shall be authorized to
            issue more than one class of stock, no outstanding share of any
            class of stock which is denied voting power under the provisions of
            the certificate of incorporation shall entitle the holder thereof to
            the right to vote at any meeting of stockholders except as the
            provisions of paragraph (2) of subsection (b) of ' 242 of the
            General Corporation Law of the State of Delaware shall otherwise
            require; provided, that no share of any such class which is
            otherwise denied voting power shall entitle the holder thereof to
            vote upon the increase or decrease in the number of authorized
            shares of said class.

            NINTH: The personal liability of the directors of the corporation is
hereby eliminated to the fullest extent permitted by the provisions of paragraph
(7) of subsection (b) of ' 102 of the General Corporation Law of the State of
Delaware, as the same may be amended and supplemented.

            TENTH: The corporation shall, to the fullest extent permitted by the
provisions of ' 145 of the General Corporation Law of the State of Delaware, as
the same may be amended and supplemented, indemnify any and all persons whom it
shall have power to indemnify under said section from and against any and all of
the expenses, liabilities, or other matters referred to in or covered by said
section, and the indemnification provided for herein shall not be deemed
exclusive of any other rights to which those indemnified may be entitled under
any Bylaw, agreement, vote of stockholders or disinterested directors or
otherwise, both as to action in his official capacity and as to action in
another capacity while holding such office, and shall continue as to a person
who has ceased to be a director, officer, employee, or agent and shall inure to
the benefit of the heirs, executors, and administrators of such a person.

            ELEVENTH: From time to time any of the provisions of this
certificate of incorporation may be amended, altered, or repealed, and other
provisions authorized by the laws of the State of Delaware at the time in force
may be added or inserted in the manner and at the time prescribed by said laws,
and all rights at any time conferred upon the stockholders of the corporation by
this certificate of incorporation are granted subject to the provisions of this
Article ELEVENTH.


                                       A-1



                                 April 16, 1999


Dr. Bengt Agerup
Managing Director
Q-Med AB
80 rue Jouffroy d'Abbans
750 17 Paris, France

Dear Dr. Agerup:

     This will confirm our agreement in principle pursuant to which Q-Med
AB (AQ-Med@) or a wholly-owned subsidiary thereof will purchase an initial 50%
interest in the capital stock of Ixion Biotechnology, Inc. (AIxion@) through the
purchase of newly-issued common stock of Ixion, and will execute a royalty free
license to its non-animal stabilized hyaluronic acid (ANASHA@) technology in the
field of islet cell encapsulation to Ixion.

     1. The number of shares to be purchased by Q-Med shall be not less than
3,000,000 shares of newly-issued common stock of Ixion for consideration
consisting of a cash price of $2.00 per share, and a royalty-free license to
NASHA technology for the field of islet cell encapsulation.

     2. The agreement set forth in this letter shall be a binding agreement
between us, subject to the following conditions:

        (a)  The board of directors of Ixion and the board of directors of
             Q-Med shall have approved the transaction contemplated hereby
             prior to July 15, 1999, unless extended by mutual agreement; and

        (b)  A mutually satisfactory formal stock purchase agreement as
             hereinafter described, shall have been prepared and executed.

     3. The stock purchase agreement (which shall be drafted by counsel for
Q-Med) shall contain such representations, warranties, covenants, terms
and conditions as are mutually acceptable to counsel to the parties
hereto, specifically including the following:

        (a)  The number of shares to be purchased by Q-Med shall be equal to
             the sum of (i) 2,514,014 (the number of shares outstanding on the
             date hereof; (ii) 100,900 (the number of options to purchase
             shares outstanding on the date hereof; (iii) 23,630 (the number of
             shares issuable upon the exercise of certain stock purchase
             warrants; (iv) 21,513 (the number of shares issuable upon the
             exercise of Charitable Benefit Warrants, after adjustment); (v)
             51,630 (the number of shares to be issued to purchasers in the
             Ixion public offering to adjust the price of their shares);
             288,313 (shares to be reserved for issuance under the Ixion Board
             Retainer Plan and the 1994 Stock Option Plan); and (vi) a number
             of shares equal to the number of shares which are purchased by
             current shareholders of Ixion pursuant to an offer in the nature
             of a preemptive right to be made to current shareholders at a price
             of not less than $2.00/share;

       (b)   Payment by Q-Med in the amount of $3,300,000 (plus accrued interest
             on the loan described below) shall be made on the Closing Date,
             which shall be September 1, 1999. On that date, Ixion will issue
             the number of shares equal to $3,300,000 plus accrued interest
             divided by $2.00, or approximately 1,650,000 shares. On the Closing
             Date, Ixion shall issue warrants for the remainder of the shares to
             be purchased by Q-Med (not less than 1,350,000 shares) with an
            exercise price of $2.00 per share, expiring on the first anniversary
             of the Closing Date.

      (c)    On the Closing Date, Dr. Bengt Agerup will be added to the board of
             Ixion as an inside director.

      (d)    The closing of the stock purchase agreement will be contingent on
             (i) Q-Med's successful completion of an initial public offering not
             later than July 15, 1999, (ii) the stockholders of Ixion approval
             of an increase in the number of authorized shares of common stock
             as set forth in the preliminary proxy statement filed with the
             Securities and Exchange Commission on April 8, 1999; (iii) Ixion's
             not, since the date hereof, having (a) disposed or made changes in
             its assets or incurred any liability other than in the ordinary
             course of business, (b) made any material changes in its business
             structure, or (c) declared any dividend or made any other
             distribution to its shareholders.

      (e)    Upon the issuance of shares of newly-issued stock by Ixion after
             the initial Closing Date, Q-Med shall have the right to purchase
             for cash such number of shares, at the same price per share as such
             shares are offered to third parties, as are necessary to maintain
             its percentage interest in Ixion.

      (f)    Royalty-free license of NASHA for use as an encapsulation material
             for Ixion islets.

     4.  Each party agrees to proceed in good faith and with all due diligence
to enter into the formal stock purchase agreement and to close the transaction
contemplated hereby. In the event that such stock purchase agreement is not
executed on or prior to June 15, 1999, either party may terminate this agreement
by giving written notice to the other. Between the date hereof and the date of
any such notice, Ixion will not entertain or accept any offers for the purchase
of its stock and shall suspend its public offering of stock pursuant to its
current registration statement.

     5.  In connection with of the closing of the stock purchase transaction
contemplated by this agreement, Ixion shall have the right to make an offer to
its current shareholders permitting them to purchase a number of shares at a
price of $2.00 per share equal to the number of shares held by them (or equal
to the number of shares which they may purchase through the exercise of options
or warrants) such that they may substantially protect their current percentage
ownership of Ixion. Ixion may cancel and reissue all options issued at a price
greater than $4.00 per share with a new exercise price of $4.00 per share.

     6.  Upon the execution of the stock purchase agreement, Ixion will make
the following offer to holders of its unsecured convertible debentures: (a) All
holders will be given 60 days from the Closing Date to elect to convert their
debentures at the price of $2.00 per share;


<PAGE>


          (b)  Q-Med will offer to redeem, at the maturity date, from all
               holders electing not to convert at such date, all variable rate
               unsecured debt at a price equal to par, plus an amount equal to
               accrued interest at 10% for the life of the debenture.

     6    The parties agree to consult with each other regarding any press
releases or other public disclosures related to this agreement in principal or
the transactions contemplated hereby.  Q-Med understands that the U.S. federal
securities laws will apply to disclosures required to be made by Ixion.

     7.   In consideration for Ixion's agreeing to not entertain or accept any
offers between the date hereof and June 15, 1999, and its agreement to suspend
its public offering, Q-Med shall lend Ixion $300,000 payable upon execution of
this letter, for the purpose of purchasing certain equipment and funding Ixion's
operating costs. The terms of the loan are set forth in the promissory note
attached hereto as Annex A. The terms of the loan shall survive termination of
this agreement.

     If the foregoing correctly sets forth our agreement, please sign and return
to us the copy of this letter enclosed for the purpose, at which time this
letter shall become a binding agreement between us.


                              Sincerely yours,

                              Ixion Biotechnology, Inc.

                              By:     /s/ Weaver H. Gaines

                              Weaver H. Gaines
                              Chairman and Chief Executive Officer

Q-Med AB

By: /s/ Bengt  Agerup
    Bengt Agerup
    Managing Director


<PAGE>


Exhibit A

                     Unsecured Convertible Promissory Note

                                                                April 16, 1999

$300,000.00
Alachua, Florida

            1. FOR VALUE RECEIVED, Ixion Biotechnology, Inc., a Delaware
corporation (the "Maker") hereby promises to pay to the order of Q-Med AB, on
September 1, 1999, the amount of $300,000, together with interest accruing from
the date hereof on the unpaid principal amount of this Note.

     2. Interest shall be set at the prime rate in effect at the beginning of
each month and on the date hereof, as set forth in the Wall Street Journal, plus
3%. Interest will be computed on the basis of a 360-day year, 30 day month.

     3. Maker shall accrue interest on this Note monthly on the last day of the
month for such month. Interest shall not be paid in cash but shall be added to
the principal of the Note on the date interest is due.

     4. If suit is instituted to collect this Note or any portion thereof, the
Maker hereby promises to pay to the holder, in addition to the principal and
interest due hereunder, all costs of collection hereof, together with such
amount as any court of competent jurisdiction may adjudge reasonable as said
holder's attorney's fees in said suit.

      5. Accrued interest shall be entered by the Maker on the Schedule
attached to the copy of the Note held at the Maker's principal offices. Holder
shall be entitled to a copy of the Schedule, certified by the Treasurer as of a
particular date, upon written request.

      6. On September 1, 1999, this Note may be converted, at Maker's sole
election, into common stock of the Maker for the account of Holder at a price of
$2.00 per share. Fractional shares shall not be issued but shall be paid to
Holder in cash. Notice of such election must be in writing and may be given at
any time prior to the maturity date hereof.

      7. This Note shall be construed in accordance with and governed by the
laws of the State of Florida.

      8. The Maker hereby waives presentment and demand for payment, notice of
dishonor, protest, and any and all other notices or demands in connection with
the delivery, acceptance, performance, default or enforcement of this Note.

                              Ixion Biotechnology, Inc.


                              By
                              Weaver H. Gaines
                              Chairman and Chief Executive Officer

Attest:

Mary Trew, Secretary



                                                                             1

                            Ixion Biotechnology, Inc.

                            1994 Board Retainer Plan

                     as amended March 22, 1999June 27, 1997

            1. Purpose of Plan. The purpose of the Ixion Biotechnology, Inc.
1994 Board Retainer Plan (the "Plan") is to provide a means by which Ixion
Biotechnology, Inc. (the "Company") may attract and retain Outside Directors,
Members of the Scientific Advisory Board, and certain key employees, and key
consultants by providing those personnel with an opportunity to participate in
the growth, development and financial success of the Company which their
efforts, initiative, and skill have helped produce.

            2. Definitions. Wherever the following capitalized terms are used in
the Plan, they shall have the following respective meaning:

            2.1 "Award" means a grant of fully-paid and non-assessable shares of
Common Stock under the Plan.

            2.2 "Board of Directors" means the board of directors of the
Company.

            2.3 "Change in Control" shall be deemed to have occurred if:

                (a) any "person" (as such term is used in Sections 13(d) and
14(d) of the Exchange Act), other than a trustee or other fiduciary holding
securities under an employee benefit plan of the Company, a corporation owned
directly or indirectly by the stockholders of the Company in substantially the
same proportions as their ownership of the Common Stock, becomes the
"beneficial owner" (as defined in Rule 13d-3 under the Exchange Act), directly
or indirectly, of securities of the Company representing 50% or more of the
total voting power represented by the Company's then outstanding securities
which vote generally in the election of Directors (referred to herein as
"Voting Securities"); or

                 (b) during any period of two consecutive years, individuals
who at the beginning of such period constitute the Board of Directors and any
new Directors whose election by the Board of Directors or nomination for
election by the Company's stockholders was approved by a vote of at least
two-thirds (2/3) of the Directors then still in office who either were
Directors at the beginning of the period or whose election or nomination for
election was previously so approved, cease for any reason to constitute a
majority thereof; or

                  (c) the stockholders of the Company approve a merger or
consolidation of the Company with any other entity, other than a merger or
consolidation which would result in the voting securities of the Company
outstanding immediately prior thereto continuing to represent (either by
remaining outstanding or by being converted into voting securities of surviving
entity) more then 50% of the total voting power represented by the voting
securities of the Company or such surviving entity outstanding immediately after
such merger or consolidation; or

                   (d) the stockholders of the Company approve a plan of
complete liquidation of the Company or an agreement for the sale or disposition
by the Company of (in one transaction or a series of transactions) all or
substantially all of the Company's assets.

            2.4 "Committee" means the Audit and Benefits Committee of the
Company.

            2.5  "Common Stock" means the Common Stock of the Company, par
value $0.01 per share.

            2.6  "Company" means Ixion Biotechnology, Inc., a Delaware
corporation.

            2.7  "Director" or "Outside Director" means a member of the Board
of Directors who is not an officer or employee of the Company.

            2.8 "Disability" or "disabled" means, with respect to a Participant
a physical or mental condition resulting from any medically determinable
physical or mental impairment that renders such person incapable of engaging in
any substantial gainful employment and that can be expected to result in death
or that has lasted or can be expected to last for a continuous period of not
less than six consecutive months.

            2.9 "Exchange Act" means the Securities Exchange Action of 1934, as
amended.

            2.10  "Fair Market Value" means the per share value of the Common
Stock as of a given date, determined as follows:

                (a) If the Common Stock is listed or admitted for trading on
any national securities exchange, the Fair Market Value of the Common Stock is
the closing quotation for such stock on the day preceding such date, or, if
shares were not traded on the day preceding such date, then on the next
preceding trading day during which a sale occurred.

                 (b) If the Common Stock is not traded on any national
securities exchange, but is quoted on the National Association of Securities
Dealers, Inc. Automated Quotation System (Nasdaq System) or any similar system
of automated dissemination of quotations of prices in common use, the Fair
Market Value of the Common Stock is the last sales price (if the stock is then
listed as a national market issue under the Nasdaq System) or the mean between
the closing representative bid and asked prices (in all other cases) for the
stock on the day preceding such date as reported by Nasdaq System (or such
similar quotation system).

                  (c) If neither clause (a) nor clause (b) of this Section 2.9
is applicable, the Fair Market Value of the Common Stock is the fair market
value per share as of such valuation date, as determined by the Board of
Directors in good faith and in accordance with uniform principles consistently
applied. Such Fair Market Value shall be determined on a regular basis, not
less than annually.

            2.11 "Member of the Scientific Advisory Board" means a member of the
Company's Scientific Advisory Board.

            2.12  "Officer" means an officer of the Company, as defined in Rule
16a-1(f) under the Exchange Act, as such rule may be amended from time to time.

            2.13  "Participant" means an Director, or Member of the Scientific
Advisory Board, key employee, or key consultant to whom an award is granted
under this Plan.

            2.14  "Plan" means the Ixion Biotechnology, Inc.1994 Board Retainer
Plan, as it may be amended from time to time.

            2.15  "Rule 16b-3" means Rule 16b-3 promulgated under the Exchange
Act, as such rule may be amended from time to time.

            2.16  "Secretary" means the Secretary of the Company.

            2.17 "Securities Act" means the Securities Act of 1933, as amended.

            2.18 "Termination of Relationship" means with respect to any
Director, Member of the Scientific Advisory Board, or employee, or consultant,
the time when such person ceases to be a Director, Member of the Scientific
Advisory Board, or employee, or consultant of the Company for any reason, with
or without cause, including without limitation, a termination by resignation,
removal, death, disability, or failure to be nominated or reelected by the
Company's stockholders. Nothing in this Plan shall confer upon any such person
Director, Member of the Scientific Advisory Board, or employee, any right to
continue his or her association with the Company or shall interfere with or
restrict in any way the rights of the Company and its stockholders, which are
hereby expressly reserved, to remove any such person at any time for any reason
whatsoever, with or without cause.

            3.  Stock Subject to Plan.

            3.1 Stock Subject to Plan. The stock subject to an Award shall be
shares of the Company's Common Stock. The aggregate number of such shares issued
and outstanding Directors or Members of the Scientific Advisory Board pursuant
to Awards shall not exceed 250,000.

            3.2 Changes in Company Capitalization. In the event that (i) the
outstanding shares of Common Stock are hereafter changed into or exchanged for a
different number or kind of shares or other securities of the Company, or of
another entity, by reason of reorganization, merger, consolidation,
recapitalization, reclassification, or (ii) the number of shares is increased or
decreased by reason of a stock split, stock dividend, combination of shares or
any other increase or decrease in the number of such shares of Common Stock
effected without receipt of consideration by the Company (provided, however,
that conversion or exchange of any convertible or exchangeable securities of the
Company shall not be deemed to have been "effected without receipt of
consideration"), then the Committee shall make appropriate adjustments in the
number and kind of shares available for Awards, including adjustments to the
limitations in Section 3.1 on the maximum number and kind of shares which may be
issued and outstanding pursuant to Awards.

            4.  Granting of Awards

            4.1 Eligibility. Any serving Outside Director or, Member of the
Scientific Advisory Board, and any or newly-hired key employee or consultant,
shall be eligible for Awards.

            4.2 Grants. Each person who is an Outside Director or Member of the
Scientific Advisory Board of the Company at the date of the adoption of this
Plan shall be granted an Award of 5,000 shares of Common Stock. Thereafter,
immediately following the Annual Meeting of the Company, the Committee shall
grant a further Award of 1,000 shares of Common Stock to each Participant (so
long as he or she is an Outside Director or Member of the Scientific Advisory
Board on each such date). Employees and consultants may be granted Awards in
connection with employment or otherwise upon recommendation by the Committee and
approval by the Board.

            4.3  Administration of the Plan.

              (a)  The Plan shall be administered by the Committee.  The
Committee shall consist of at least two Outside Directors (if there are such)
selected by the Board of Directors. Committee members may resign by delivering
written notice to the Secretary. Vacancies on the Committee shall be filled by
the Board of Directors.

              (b) Except as otherwise provided in the Plan and except as
otherwise expressly stated to the contrary in the Company's Certificate of
Incorporation, Bylaws, or elsewhere, the Committee shall have the sole
discretionary authority (i) to impose such conditions and restrictions on
Awards as it determines appropriate, (ii) to interpret the Plan, (iii) to
prescribe, amend, and rescind rules and regulations relating to the Plan, (iv)
to determine Fair Market Value in accordance with Section 2.9 (c), and (v) to
take any other actions in connection with the Plan and to make all
determinations under the Plan as it may deem necessary or advisable for the
administration of the Plan. The determinations of the Committee on the matters
referred to in this Section 4 shall be binding and conclusive on all persons.

               (c) A majority of the members of the Committee shall constitute
a quorum. All determinations of the Committee shall be made by a majority of
its members. Any decision or determination reduced to writing and signed by all
of the members of the Committee shall be fully effective as if it had been made
by a majority vote at a meeting duly called and held.

               (d) The Committee may delegate to one or more persons any of its
powers, or designate one or more persons to do or perform those matters to be
done or performed by the Committee, including administration of the Plan. Any
person or persons delegated or designated by the Committee shall be subject to
the same obligations and requirements imposed on the Committee and its members
under the Plan.

               (e) Members of the Committee shall receive such compensation for
their services as members as may be determined by the Board of Directors. All
expenses and liabilities incurred by members of the Committee in connection
with the administration of the Plan shall be borne by the Company. The
Committee may employ attorneys, consultants, accountants, appraisers, brokers,
or other persons. The Committee, the Company, and its Officers and Directors
shall be entitled to rely upon the advice, opinions, or valuations of any such
persons. All elections taken and all interpretations and determinations made by
the Committee in good faith shall be final and binding upon all Participants,
the Company, and all other interested persons. No member of the Committee shall
be personally liable for any action, determination or interpretation made in
good faith with respect to the Plan. Members of the Committee and each person
or persons designed or delegated by the Committee shall be entitled to
indemnification by the Company for any action or any failure to act in
connection with services performed by or on behalf of the Committee for the
benefit of the Company to the fullest extent provided or permitted by the
Company's Certificate of Incorporation, Bylaws, any insurance policy, or other
agreement intended for the benefit of the Committee, or by any applicable law.

            5.  Terms of Grants

            5.1 Grant Agreement. Each Grant shall be evidenced by a written
Grant Agreement, which shall be signed by the Participant and by an authorized
Officer of the Company and which shall refer to such terms and conditions as the
Committee shall determine, consistent with the Plan.

            5.2 Issuance of Shares. Participants shall be issued a certificate
for fully-paid and nonassessable shares of Common Stock for the number of shares
covered by the Award, which certificate may contain a legend referring to
restrictions on vesting and transfer and such other terms and conditions as the
Committee shall determine, consistent with the Plan.

            5.3 Forfeiture of Unvested Shares. Shares which have been awarded
but not yet vested under this Section 5.3 shall be forfeited if the Participant
ceases to be a Director, Member of the Scientific Advisory Board, or employee,
or consultant of the Company for any reason, with or without cause, including
without limitation, a termination by resignation, removal, death, disability, or
failure to be nominated or reelected by the Company's stockholders, unless
provided to the contrary in any Grant Agreement approved by the Committee
between the Participant and the Company, which Agreement shall govern any
further vesting of shares pursuant to Awards.

            5.4 Fair Market Value. The Company shall provide to each Participant
who receives an Award information regarding the Fair Market Value of the
Company's shares on the date such Award is granted. Such information shall be
provided to permit the Participant to determine his or her federal income tax
liability, if any, for such Award, or to permit the Participant to make the
election contemplated by Section 78 of the Internal Revenue Code.

            5.5  Transfer Restrictions; Vesting.

               (a) Unless otherwise approved in writing by the Committee, no
shares of Common Stock issued pursuant to an Award may be sold, assigned,
pledged, encumbered, or otherwise transferred until (i) they have vested, and
(ii) either the Company has made an offering of its shares to the public
pursuant to a registration statement under the Securities Act or there has
been a Change of Control of the Company, except as may be provided in Section
5.5(c) or as may otherwise be provided for in an Grant Agreement which has been
approved by the Committee. The Committee, in its absolute discretion, may
impose such other restrictions on the transferability of the shares granted
pursuant to an Award as it deems appropriate. Any such other restriction shall
be set forth in the respective Grant Agreement and may be referred to on the
certificates evidencing such shares.

                (b) Shares issued to members of the Board of Directors, or
employees, or consultants pursuant to Awards shall vest 20% at the end of the
first year of service after the date of the Award and 1/12 of 20% at the end of
each month thereafter. Subject to the provisions of Sections 5.3, 5.5(c), and
5.5(d), Awards shall otherwise become vested at such times and in such
installments (which may be cumulative) as the Committee shall provide in
the terms of each individual Grant Agreement; provided, however, that by
resolution adopted after an Award is granted the Committee may, on such terms
and conditions as it may determine to be appropriate and subject to Sections
5.3, 5.5(c), and 5.5(d), accelerate the time at which such Award or any portion
thereof may be vested, or such rights may be set forth in an agreement between
the Participant and the Company which has been approved by the Committee. Shares
issued to members of the Scientific Advisory Board shall vest 25% at the end of
each three months of service after the date of the award.

                 (c) No portion of an Award which is unvested at Termination of
Relationship shall thereafter become vested; provided, however, that provision
may be made that such Award shall become vested in the event of a Termination
of Relationship as may be determined by the Committee, or such rights may be
set forth in a Grant Agreement between the Participant and the Company which
has been approved by the Committee.

                 (d) Subject to the provisions of Section 5.5(a), the Committee
 shall provide, in terms of each individual Grant Agreement when such Award
becomes vested, and (without limiting the generality of the foregoing) the
Committee may provide in the terms of individual Grant Agreements that unvested
shares shall be forfeited immediately upon a Termination of Relationship;
provided, however, that provision may be made that such shares shall become
vested in the event of a Termination of Relationship because of the
Participant's retirement, death, disability, or as may otherwise be determined
by the Committee.

            5.6 No Right to Continued Relationship. Nothing in this Plan or in
any Grant Agreement issued hereunder shall confer upon any Participant, any
right to continue his or her association with the Company or shall interfere
with or restrict in any way the rights of the Company and its stockholders,
which are hereby expressly reserved, to remove any such person at any time for
any reason whatsoever, with or without cause.

            6.  Additional Provisions.

            6.1 Nontransferability. No unvested shares issued pursuant to an
Award or interest or right therein or part thereof shall be liable for the
debts, contracts or engagements of the Participant or his successors in interest
or shall be subject to disposition by transfer, alienation, anticipation,
pledge, encumbrance, assignment, or any other means whether such disposition be
voluntary or involuntary or by operation of law by judgment, levy, attachment,
garnishment or any other legal or equitable proceedings (including bankruptcy
and divorce proceeding), and any attempted disposition thereof shall be null and
void and of no effect.

            6.2 Securities Act. Upon issuance of Common Stock of the Company to
the Participant, or his heirs, the recipient of that stock shall represent that
the shares of stock are taken for investment and not resale and shall make such
other representations as may be necessary to qualify the issuance of the shares
as exempt from the Securities Act and applicable federal and state securities
laws and regulations, and shall represent that he or she shall not dispose of
those shares in violation of the Securities Act or of applicable federal and
state securities laws and regulations. The Company reserves the right to place a
legend on any stock certificate issued pursuant to the Plan to assure compliance
with this Section and with the vesting and transferability requirements of
Section 5. No shares of Common Stock of the Company shall be required to be
distributed until the Company shall have taken such action, if any, as is then
required to comply with the provisions of the Securities Act or any other then
applicable federal or state securities law or regulation.

            6.3 Withholding of Tax. The Company shall have the right to deduct
from any Award made under the Plan any federal, state or local income or other
taxes required by law to be withheld with respect to such Award. It shall be a
condition to the obligation of the Company to deliver Common Stock upon an Award
that the Participant pay to the Company such amount as may be requested by the
Company for the purpose of satisfying any liability for such withholding taxes.
Any grant under this Plan may provide by its terms that the Participant may
elect, in accordance with any applicable regulations, to pay a portion or all of
the amount of such minimum required or additional permitted withholding taxes in
shares of Common Stock, subject to the timing restrictions set forth in Section
6 hereof. The Participant shall authorize the Company to withhold, or shall
agree to surrender back to the Company, on or about the date such withholding
tax liability is determinable, shares of Common Stock previously owned by such
Participant or a portion of the shares that were or otherwise would be
distributed to such Participant pursuant to such award having a Fair Market
Value equal to the amount of such required or permitted withholding taxes to be
paid in shares.

            6.4 Termination and Amendment of Plan. The Committee may at any time
suspend or terminate the Plan, or make such modifications of the Plan as it
shall deem advisable, provided that the Plan not be changed to increase the cost
of the Plan to the Company. Notwithstanding anything to the contrary contained
herein, the Committee shall not amend or modify the Plan more than once every
six (6) months or in any other manner inconsistent with the requirements of Rule
16b-3(c)(2)(ii) except to the extent required by changes in the Internal Revenue
Code, the Employee Retirement Income Security Act of 1974, or regulations and
rules issued thereunder. No termination or amendment of the Plan may, without
the consent of a Participant, adversely affect the rights of such Participant
notwithstanding anything to the contrary herein. No Award may be granted during
any period of suspension of the Plan nor after termination of the Plan, and in
no event may any Award be granted under this Plan after August 30, 2004.

            6.5 Duties of the Company. The Company shall pay all original issue
taxes with respect to the issuance or delivery of shares pursuant to an Award
and all other fees and expenses necessarily incurred by the Company in
connection therewith.

            6.6 Absence of a Committee. Should the Board of Directors fail to
appoint the Committee or should there be no Committee for any other reason, then
the Plan shall be administered by the Board of Directors. In the absence of a
Committee, the Board of Directors (or that portion thereof comprised in
accordance with this Section 6.6) shall have all the powers of the Committee as
set forth herein in administration of the Plan.

            7.  General Provisions.

            7.1 No Rights. Neither the adoption and maintenance of the Plan, the
granting of Awards pursuant to the Plan, nor issuance of shares pursuant to
Awards shall be deemed to constitute a contract of employment between the
Company and any Participant or to be a condition of the employment of any
person. The Plan and any Awards granted under the Plan shall not confer upon any
Participant any right with respect to a continued relationship with the Company,
nor shall they interfere in any way with the right of the Company or its
shareholders to terminate the relationship of any Participant with the Company
at any time, and for any reason, with or without cause.

            7.2 Costs of Administration. The Company shall pay all costs and
expenses of administering the Plan.

            7.3 Controlling Laws. The issuance of shares of Common Stock under
the Plan shall be subject to all applicable laws, rules and regulations, and to
such approvals by any governmental agencies or national securities exchanges as
may be required. The provisions of this Plan shall be interpreted so as to
comply with the conditions and requirements of the Securities Act, the Exchange
Act, and rules and regulations issued thereunder, including without limitation
Rule 16b-3, unless a contrary interpretation of any such provisions otherwise
required by applicable law. Except to the extent preempted by Federal law, this
Plan and all Stock Option Agreements entered into pursuant hereto shall be
construed and enforced in accordance with, and governed by, the laws of the
State of Delaware, determined without regard to its conflict of laws rules.2

<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>

     This schedule contains summary financial information extracted from
Financial Statements for the three months ended June 30, 1999, and is
qualified in its entirety by reference to such form 10QSB for quarterly period
ended June 30, 1999.
</LEGEND>

<MULTIPLIER>                                      1

<S>                                     <C>
<PERIOD-TYPE>                                 3-MOS
<FISCAL-YEAR-END>                       Dec-31-1999
<PERIOD-END>                            Jun-30-1999
<CASH>                                       81,016
<SECURITIES>                                      0
<RECEIVABLES>                                 6,916
<ALLOWANCES>                                      0
<INVENTORY>                                       0
<CURRENT-ASSETS>                             89,791
<PP&E>                                      106,924
<DEPRECIATION>                                    0
<TOTAL-ASSETS>                              530,855
<CURRENT-LIABILITIES>                       854,408
<BONDS>                                           0
<COMMON>                                  1,686,526
                             0
                                       0
<OTHER-SE>                               (3,590,603)
<TOTAL-LIABILITY-AND-EQUITY>                530,855
<SALES>                                           0
<TOTAL-REVENUES>                              1,165
<CGS>                                             0
<TOTAL-COSTS>                                     0
<OTHER-EXPENSES>                            217,559
<LOSS-PROVISION>                                  0
<INTEREST-EXPENSE>                           37,559
<INCOME-PRETAX>                            (253,993)
<INCOME-TAX>                                      0
<INCOME-CONTINUING>                        (253,993)
<DISCONTINUED>                                    0
<EXTRAORDINARY>                                   0
<CHANGES>                                         0
<NET-INCOME>                               (253,993)
<EPS-BASIC>                                  (.10)
<EPS-DILUTED>                                     0





</TABLE>


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