IXION BIOTECHNOLOGY INC
8-K, EX-99.2, 2000-07-28
PHARMACEUTICAL PREPARATIONS
Previous: IXION BIOTECHNOLOGY INC, 8-K, EX-99.1, 2000-07-28
Next: IXION BIOTECHNOLOGY INC, 8-K, EX-99.3, 2000-07-28





                             SHAREHOLDERS' AGREEMENT


     THIS  SHAREHOLDERS'  AGREEMENT  ("Agreement"),  made and entered into as of
this 14th day of  July,  2000 (the  "Effective  Date")  by and among  IXION
BIOTECHNOLOGY,  INC., a Delaware corporation (the  "Corporation"),  and Q-MED AB
(publ), a Swedish company  ("Q-MED"),  QVESTOR LLC, a Delaware Limited Liability
Company  ("QVESTOR"),  AMMON B. PECK Ph.D and  WEAVER H.  GAINES,  (referred  to
herein   individually   as   the   "Shareholder"   and   collectively   as   the
"Shareholders"), as follows:

                              W I T N E S S E T H:
                              --------------------

       WHEREAS,  the  Shareholders  are  now  the  owners  of a  majority  of
the Corporation's outstanding shares of stock (the "Shares"); and

       WHEREAS,  the Shareholders desire to promote their mutual interests and
the interest of the Corporation by imposing certain restrictions and obligations
on  themselves,  the  Corporation,  and the  Shares  pursuant  to the  terms and
conditions of this Agreement.

       NOW,  THEREFORE,  in  consideration  of the  premises and of the mutual
covenants  set forth herein and for other good and valuable  consideration,  the
receipt  and  sufficiency  of which are  hereby  acknowledged,  intending  to be
legally bound, the parties agree as follows:

                                      TERMS
                                      -----

       1.      DEFINITIONS

       For  purposes of this  Agreement,  the  following  terms shall have the
meaning indicated below:

       "Dispose Of" shall mean pledge,  hypothecate,  give, assign,  encumber,
sell,  grant an option  with  respect  to, or  otherwise  transfer,  other  than
pursuant to a plan of merger or consolidation,  to anyone,  whether or not it is
then a Shareholder;  provided, however, that a pledge by all Shareholders of all
Shares to secure  future  financing  for the  Corporation  shall not be deemed a
disposition of Shares.

       2.       RESTRICTION ON DISPOSITION

                (a) While this  Agreement  is in force and  effect,  no
Shareholder  shall  Dispose  Of its  interest  in any of the Shares now or later
owned by it, except by the terms of this  Agreement.  Any attempted or purported
transfer of an ownership  interest in violation of this Agreement  shall be void
and shall constitute an

<PAGE>

abandonment  of the  Shareholder's  Shares.  No transfer of ownership  interests
pursuant to this Agreement  shall be recognized by the  Corporation  until it is
duly  entered upon the books and records of the  Corporation  and all indicia of
ownership are changed accordingly.

                (b) The Share  certificates  shall bear the following  legend or
a legend to the following effect:

          These  shares have not been  registered  under the  Securities  Act of
          1933,  and may not be  sold,  transferred,  pledged,  or  hypothecated
          except  pursuant  to  registration  under such Act or  pursuant  to an
          available  exemption from registration under said Act. The transfer of
          these shares is further  restricted under the terms of a Shareholders'
          Agreement  dated  as of July  14,  2000  between  the  holder  of this
          certificate  and the  Corporation,  a copy of  which is on file at the
          principal office of the Corporation. No transfer will be recognized by
          the Corporation  until, as the case may be, counsel to the Corporation
          is satisfied  there is no violation of the Securities Act of 1933, the
          other shareholders consent to the transfer, or both.

                (c) By virtue of such legend and with notice,  any  transferee
of the Shares of the Corporation becomes a party to, and is bound by, this
Agreement.

     3.         DISPOSITIONS OF SHARES

                (a)  Restriction.  No  Shareholder  shall  Dispose Of his or its
Shares,  except  pursuant  to the terms of this  Agreement,  provided  that this
section 3 shall not apply to (i) bona fide gifts or bequests by any  Shareholder
to a third person or member of the Shareholder's  family or (ii) bona fide gifts
or bequests by a  Shareholder  to a charitable  institution  or not-for-  profit
entity, where the cumulative total of subsections (i) and (ii) do not exceed ten
percent of the Shareholder's fully diluted holdings of the Shares measured as of
the date of the gift or bequest.

                (b)  Corporation's  Option to Purchase  Shares.  A  Shareholder
(the "Offering Shareholder") who desires to Dispose Of any Shares in response to
a bona fide offer from a third party (the "Third Party Offer") shall first offer
such Shares to the Corporation and the other  Shareholders at the same price and
on the same terms contained in the Third Party Offer.  The Offering  Shareholder
shall  give a  notice  ("Notice")  signed  by the  Offering  Shareholder  to the
Corporation  and on the same day give Notice to the other  Shareholders  of such
Offering  Shareholder's desire to Dispose Of his or its Shares. The Notice shall
specify the number of Shares (the  "Offered  Shares") the  Offering  Shareholder
intends to Dispose Of and the purchase  price and terms of any offer to purchase
the Shares  made by the Third  Party  Offeror.  The  Corporation  shall have the
irrevocable and exclusive first option, but not the obligation,  to purchase all
or, subject to paragraph 3(c) below, a
                                       2
<PAGE>

part of the  Offered  Shares,  at the  price  and on  substantially  the same or
comparable  terms to those set forth in the  Notice,  provided  the  Corporation
gives  notice of its  election to purchase to the  Offering  Shareholder  within
thirty (30) days after the Corporation receives the Notice.

                (c) Other  Shareholders'  Option to Purchase Shares. If the
Corporation  does not elect to purchase all of the Offered Shares covered by the
Notice as provided in paragraph  3(b),  then,  subject to paragraph  3(e),  each
Shareholder  other than the Offering  Shareholder shall have the irrevocable and
exclusive second option,  but not the obligation,  to purchase from the Offering
Shareholder that part of the Offered Shares that the Corporation has not elected
to  purchase,  pro rata to its  holdings  of Shares on the date the  Corporation
received the Notice (exclusive of the Shares offered for sale or otherwise owned
by the Offering  Shareholder).  Each Shareholder  who elects to purchase all or
a part of its pro rata  portion of the Offered  Shares shall give notice of such
election to the Offering Shareholder and the other Shareholders, as the case may
be,  within  forty-five  (45)  days  after  the  receipt  of the  Notice  by the
Corporation.  Each  such  notice  shall  state the  number  of Shares  which the
Shareholder  giving the notice elects to purchase.  The purchase  price shall be
the same as set forth in the Third Party Offer.

                    (i) If any Shareholder fails to exercise its right to
purchase  its full pro rata  portion of the  Offered  Shares,  each of the other
Shareholders  who has given  notice of election  to  purchase  its full pro rata
portion of the Offered  Shares shall have an additional  ten (10) days after the
expiration  of such  forty-five  (45) day  period in which to give the  Offering
Shareholder and the other Shareholders, further notice (the "Further Notice") of
its  election to purchase all or a part of the  Remaining  Shares (as defined in
(ii) below).  Each Further  Notice shall state the number of  additional  Shares
that the  Shareholder  giving the Further Notice elects to purchase.  The Shares
shall be apportioned  among those  Shareholders  who have given a Further Notice
according to the procedure described below or in such different portions as such
Shareholders may agree among themselves. Each of the Participating Shareholders,
as defined in (ii) below,  shall be  apportioned  (1) that number of  additional
Shares that it elected to  purchase  in its Further  Notice and which it has not
yet been  apportioned  pursuant to this paragraph  3(c)(i),  or (2) its pro rata
portion of the Unpurchased Shares (as defined in (ii) below), whichever is less.
If the  apportionment  is followed and there  remain at least one  Participating
Shareholder and any Unpurchased  Shares, the procedure  described above shall be
repeated.

                    (ii) For purposes of paragraph 3(c)(i), the following
definitions shall apply:

                         (1) The "Remaining  Shares" shall be the Offered Shares
that the Corporation and the Shareholders have not elected to purchase.

                                       3

<PAGE>

                         (2) A "Participating Shareholder" shall be a
Shareholder who has given a Further Notice and who has not yet been apportioned
pursuant to paragraph 6(c)(i) that number of additional Shares that it elected
to purchase in its Further Notice.

                         (3)  "Unpurchased  Shares" shall be the Remaining
Shares that have not yet been apportioned to Participating Shareholders pursuant
to paragraph 3(c)(i).

                         (4) A "Participating  Shareholder's Pro Rata Portion"
of the Unpurchased  Shares shall be the number of Unpurchased  Shares multiplied
by the fraction formed by dividing the number of Shares that such  Participating
Shareholder  held on the date the Corporation  received the Notice by the number
of  Shares  that  all of the  Participating  Shareholders  held on the  date the
Corporation received the Notice.

                (d)     Effect of an Election to Purchase.  The  Corporation
and each  Shareholder  giving notice of election to purchase  Shares pursuant to
paragraph  3(b) or 3(c),  respectively,  shall be obligated  severally  (but not
jointly)  to  purchase   from  the  Offering   Shareholder,   and  the  Offering
Shareholder,  provided the Corporation, the other Shareholders, or a combination
of the  Corporation  and the other  Shareholders  elect to  purchase  all of the
Offered  Shares,  shall be  obligated  to sell to the  Corporation  or the other
Shareholders, or the Corporation and the other Shareholders, as the case may be,
the number of Offered Shares stated therein,  at the price and on  substantially
similar terms to those contained in the Third Party Offer.


                (e)     Consequences  if Not All  Shares  are to be  Purchased.
If an  Offering  Shareholder  gives  Notice and the  Corporation,  and the other
Shareholders do not elect,  pursuant to paragraphs 3(b) and 3(c),  respectively,
to purchase all of the Offered  Shares,  the Offering  Shareholder  may elect to
sell to the  Corporation,  if it has  elected to  purchase  part of the  Offered
Shares and to the Shareholders, if any, who have elected to purchase part of the
Offered  Shares,  the aggregate  number of such Shares which the Corporation and
such  Shareholders  have  elected to purchase at the price and on  substantially
similar terms to those  contained in the Third Party Offer.  If the  Corporation
and the other  Shareholders  have failed to elect to purchase all of the Offered
Shares pursuant to the provisions  above, the Offering  Shareholder may sell the
Offered  Shares (i) to the third party  offeror  identified in the Notice at the
price and on the terms  contained  in the Third Party Offer or (ii) to any other
third party at the identical terms set forth in the Third Party Offer. Such sale
to a third party must be closed within thirty (30) days after nonelection by the
Corporation and the other  Shareholders.  If such sale is not closed within such
time  period,  the  sale of the  Offering  Shareholder's  Shares  will  again be
governed by the provisions of this section 3.

                                       4

<PAGE>

                (f)     Restrictions  on Third  Party  Purchaser.
Notwithstanding  an Offering  Shareholder's  right to sell  Offered  Shares to a
third party as set forth above,  the Offering  Shareholder  may not sell Offered
Shares to any competitor or potential competitor of the Corporation.


                (g)     Continuing Restriction on Remaining Shares. If any
Shares have been offered for sale  pursuant to this section 3 and that offer has
not been finally  accepted in accordance  with the provisions of this section 3,
then such Shares still owned by the Offering Shareholder shall remain subject to
the terms of this Agreement.


                (h)     Q-MED  and  QVESTOR  Exception.   Notwithstanding   the
above  provisions  of this Section 3, Q-MED and QVESTOR may sell,  transfer,  or
assign their respective Shares of the Corporation to any subsidiary or affiliate
of Q-MED or any  business  entity in which  Q-MED owns an  interest in excess of
fifty percent (50%),  without first  offering such shares to the  Corporation or
the other shareholders.

     4.         DEATH, DISSOLUTION OR DISABILITY OF SHAREHOLDER

                (a)     Death or Dissolution of Shareholder

                       (i)      Option to  Purchase  Shares on Death or
Dissolution of Shareholder.  Subject to the terms of section 4 (d) hereof,  upon
the  death  of a  Shareholder  (a  "Decedent")  or  upon  the  dissolution  of a
Shareholder  which is an Entity,  whether by  operation of law,  judicially,  or
voluntarily (a "Dissolved  Shareholder") during the term of this Agreement,  the
Corporation and the remaining Shareholders ("Remaining Shareholders") shall have
the irrevocable  and  exclusive  successive  options,  but not the  obligation,
subject  to  subsection   4(a)(vi)  hereof,   to  purchase,   and  the  personal
representative  of the Decedent or the  Trustee(s) of the Dissolved  Shareholder
shall sell all of the Decedent's or Dissolved  Shareholder's Shares owned at the
date of death or  dissolution,  at the price and in the manner set forth in this
Agreement. The provisions of this section will apply to any Shares held by joint
tenancy only upon the death of both joint tenants.

                       (ii)  Corporation's  First Option to Purchase Shares. The
Corporation  shall have the  irrevocable  and exclusive first option to purchase
all, but not less than all, of the Decedent's or Dissolved Shareholder's Shares,
provided  the  Corporation  gives  notice of its  election  to  purchase  to the
personal  representative  of the  Decedent or the  Trustee(s)  of the  Dissolved
Shareholder  within  thirty  (30)  days  after  the date of  appointment  of the
personal  representative of the Decedent's estate ("Date of Appointment") or the
date of dissolution of the Dissolved  Shareholder  (the "Date of  Dissolution").
The purchase  price to be paid by the  Corporation  shall be

                                       5

<PAGE>

equal to the Agreed  Value of the Shares on the date of death of the Decedent or
the Date of Dissolution.

                       (iii) Life Insurance.  The Corporation may, but is not
obligated to, secure life  insurance on the  Shareholders  from a life insurance
company  selected by the  Corporation.  This  insurance need not be in an amount
necessary to pay the entire purchase price for the Shares at death.  Each of the
Shareholders agrees to do everything necessary to cause insurance policies to be
issued  pursuant  to this  Agreement,  if the  Corporation  elects to do so. The
Corporation,  which shall be the owner of the life insurance policies, agrees to
pay the  premiums  as they become  due,  and each  policy  shall be the sole and
absolute  property of the Corporation.  Any dividends  payable upon the policies
prior to maturity by the death of the insured  Shareholder  shall be paid to the
Corporation in cash or disposed of as the Corporation may direct. This Agreement
shall  extend to and include  all  additional  life  insurance  policies  issued
pursuant to this Agreement.

                      (iv) Shareholders' Second Option to Purchase Shares. If
the  Corporation  does not  elect to  purchase  the  Shares of the  Decedent  or
Dissolved  Shareholder  as  provided in  subsection  4(a)(ii),  then  subject to
subsection 4(a)(vi),  the Remaining  Shareholders shall have the irrevocable and
exclusive second option,  but not the obligation,  to purchase from the personal
representative  of the Decedent or the Trustee(s) of the Dissolved  Shareholder,
that part of the Shares, pro rata, to such Remaining  Shareholder's  holdings of
Shares on the date of death of the  Decedent  or the Date of  Dissolution.  Each
Remaining Shareholder who elects to purchase all or part of its pro rata portion
of the  Decedent's or Dissolved  Shareholder's  Shares shall give notice of such
election to the personal representative of the Decedent or the Trustee(s) of the
Dissolved  Shareholder and to the Remaining  Shareholders within sixty (60) days
after the Date of Appointment or the Date of Dissolution.  The purchase price to
be paid shall be equal to the Agreed Value of the Shares on the date of death of
the Decedent or the Date of Dissolution.

                              (aa)    If any  Remaining  Shareholder  fails to
exercise  its right to purchase  its full pro rata  portion of the Shares of the
Decedent or the Dissolved Shareholder,  each Remaining Shareholder who has given
notice of election to  purchase  its full pro rata  portion of the Shares of the
Decedent or the Dissolved  Shareholder shall have an additional twenty (20) days
after  the  expiration  of such  sixty  (60) day  period in which to give to the
personal  representative  of the  Decedent or the  Trustee(s)  of the  Dissolved
Shareholder  and the other Remaining  Shareholders further notice (the "Further
Notice") of its election to purchase all or a part of the Shares of the Decedent
or the  Dissolved  Shareholder.  Each  Further  Notice shall state the number of
additional  shares that the  Remaining  Shareholder  giving the  Further  Notice
elects to  purchase.  The Shares  shall be  apportioned  among  those  Remaining
Shareholders  who  have  given  a  Further  Notice  according  to the  procedure
described  below or in such different  portions as such  Shareholders  may agree
among themselves. Each of the

                                       6

<PAGE>

Participating  Shareholders  shall be apportioned  (1) that number of additional
shares of Shares that it elected to purchase in its Further Notice and which has
not yet been apportioned pursuant to this subsection 4(a)(iv)(aa) or (2) its pro
rata portion of the Unpurchased Shares,  whichever is less. If the apportionment
is followed  and there  remain at least one  Participating  Shareholder  and any
Unpurchased Shares, the procedure described above shall be repeated.

                             (bb)  For purposes of subsection 4(a)(iv)(aa),
the following definitions shall apply:

                                   a.     The  "Remaining  Shares" shall be the
Offered Shares that the Shareholders have not elected to purchase.

                                   b.     A "Participating  Shareholder" shall
be a Shareholder  who has given a Further  Notice and who has not yet been
apportioned pursuant to subsection 4(a)(iv)(aa) that number of additional shares
that he elected to purchase in his Further Notice.

                                   c.     "Unpurchased  Shares" shall be the
Remaining   Shares  that  have  not  yet  been   apportioned  to   Participating
Shareholders pursuant to subsection 4(a)(iv)(aa).

                                   d.     A  "Participating   Shareholder's Pro
Rata Portion" of the  Unpurchased  Shares shall be the number of Unpurchased
Shares  multiplied  by the  fraction  formed by dividing the number of shares of
Shares that such  Participating  Shareholder  held on the Date of Appointment or
Date  of  Dissolution  by  the  number  of  shares  of  Shares  that  all of the
Participating   Shareholders  held  on  the  Date  of  Appointment  or  Date  of
Dissolution.

                      (v)      Effect of an Election.    The  Corporation  or
each  Shareholder  giving  notice of  election to  purchase  Shares  pursuant to
subsection 4(a)(ii) or 4(a)(iv), respectively, shall be obligated severally (but
not jointly) to purchase from the personal representative of the Decedent or the
Trustee(s) of the Dissolved Shareholder,  and the personal representative of the
Decedent  or  the  trustee(s)  of  the  Dissolved   Shareholder,   provided  the
Corporation,  or such Remaining Shareholders have elected to purchase all of the
Offered Shares, shall be obligated to sell to the Corporation, or such Remaining
Shareholders, as the case may be, the number of shares of Shares of the Decedent
or Dissolved  Shareholder  stated therein,  at the price determined  pursuant to
subsection 4(a)(ii) or 4(a)(iv).

                      (vi)     Consequences  if All Shares are Not to be
Purchased. If the Corporation or the Remaining Shareholders do not elect,
pursuant to subsections 4(a)(ii) and 4(a)(iv), to purchase all of the Shares of
the Decedent or the Dissolved Shareholder, the personal representative of the
Decedent or the Trustee(s) of the Dissolved Shareholder may elect to sell to the
Remaining

                                       7

<PAGE>

 Shareholders, if any, who have elected to purchase part of the Shares
of the Decedent or the Dissolved Shareholder, the aggregate number of such
shares which such  Shareholders have elected to purchase at the price and on the
terms  and  conditions  determined  pursuant  to  subsection  4(a)(iv).  If  the
Corporation or the Remaining  Shareholders  have failed to elect to purchase all
of  the  Offered  Shares  pursuant  to  the  provisions   above,   the  personal
representative  of the Decedent or the Trustee(s) of the Dissolved  Corporation,
prior to any transfer of the Shares to a third party,  shall again offer to sell
the Shares at a purchase price equal to the price offered by the bona fide third
party purchaser, first to the Corporation and then to the Remaining Shareholders
in the same manner as set forth in Subsections 3(b) - 3(e) hereof.

                (b)      Disability of Shareholder

                        (i)      Option to  Purchase  Shares  upon  Disability
of Shareholder. Subject to the terms of section 4 (d), below, if a Shareholder
becomes physically or mentally unable to perform his or her regular and
customary duties to the Corporation for a continuous period of [one hundred
(100)] days (the "Date of Disability"), such Shareholder shall be considered
totally and permanently disabled (a "Disabled Shareholder"). The Corporation and
the Remaining Shareholders shall have the irrevocable and exclusive successive
options, but not the obligation, to purchase and the Disabled Shareholder, or
such Shareholder's guardian or other person possessing the legal power to act on
such Shareholder's behalf to satisfy his contractual obligations
("Representative"), shall sell all of the Shares owned by the Disabled
Shareholder at the Date of Disability at the price and in the manner set forth
in this Agreement.

                        (ii)     Corporation's  First Option to Purchase Shares.
Within thirty (30) days after the Date of Disability, the Corporation may elect,
at its option, to purchase all of the Shares owned by the Disabled Shareholder
in the same manner as set forth in subsection 4(a)(ii) hereof. The purchase
price of the Shares shall equal its Agreed Value as of the Date of Disability.

                        (iii)    Disability  Insurance.  In order to assure
sufficient funds are available to pay for a purchase by the Corporation of a
Shareholder's Shares in the event of his or her disability, the Corporation may,
but is not obligated to, secure disability insurance from a company selected by
the Corporation. Each of the Shareholders agrees to do everything necessary to
cause disability insurance policies to be issued pursuant to this Agreement, if
the Corporation elects to do so. The Corporation, which shall be the owner of
the disability insurance policies, agrees to pay the premiums as they become due
and each policy shall be the sole and absolute property of the Corporation. This
Agreement shall extend to and include all additional disability insurance
policies issued pursuant to this Agreement.

                                       8

<PAGE>

                        (iv)     Shareholders  Second Option to Purchase Shares.
If the Corporation does not elect to purchase the Shares owned by the Disabled
Shareholder, the Remaining Shareholders shall have the irrevocable, and
exclusive second option, but not the obligation, to purchase from the Disabled
Shareholder that part of the Disabled Shareholder's Shares, pro rata to its
holdings of Shares on the Date of the Disability in the manner provided in
subsection 4(a)(iv). The purchase price to be paid by the Remaining Shareholders
shall equal the Agreed Value of the Shares as of the Date of Disability.

                        (v)  Consequences  if all Shares are Not to be
Purchased. If the Corporation or the Remaining Shareholders do not elect,
pursuant to subsections 4(b)(ii) and 4(b)(iv), respectively, to purchase all of
the Shares of the Disabled Shareholder, the Disabled Shareholder may elect to
sell to the Remaining Shareholders, if any, who have elected to purchase part of
the Shares of the Disabled Shareholder, the aggregate number of shares of such
Shares which such Remaining Shareholders have elected to purchase at the price
determined pursuant to subsection 4(b)(iv). If the Corporation or the Remaining
Shareholders have failed to elect to purchase all of the Shares of the Disabled
Shareholder pursuant to the above provisions, the Disabled Shareholder may sell
its stock to a third party within thirty (30) days thereafter at the Agreed
Value: (i) only on the same terms and conditions as the Shares have been offered
to the Corporation and Remaining Shareholders and (ii) only if the purchaser
agrees in writing to be bound by all of the terms and conditions of this
Agreement. If such sale is not closed within thirty (30) days after nonelection
by the Corporation and Remaining Shareholders, the sale of the Disabled
Shareholder's Shares shall again be governed by provisions of this section 4.

                (c) Continuous  Restriction on Remaining Shares. If any Shares
have been  offered for sale  pursuant  to this  section 4 and that offer has not
been finally  accepted in accordance with the provisions of this section 4, then
the Shares  still  held by the  personal  representative  of the  Decedent,  the
Trustee(s) of the Dissolved Shareholder or the Disabled Shareholder shall remain
subject to the terms of this Agreement.

                (d)  Execution  of  Voting  Trust  Agreement.  In the event of
Shareholder's death,  dissolution or disability,  the personal representative of
the  Decedent  or  the   Trustee(s)  of  the  Dissolved   Shareholder,   or  the
Shareholder's Representative, within ten (10) days after receiving notice of the
election to purchase by the Corporation or the Remaining  Shareholders  pursuant
to the options set forth in section 4 (a) or (b), may take the following actions
, in which case the terms of section 4 (a) or (b) shall not apply:

                    (i)      Provide   notice  to  the   Corporation   and
Remaining Shareholders , set forth herein, that such personal representative of
the Decedent, or Trustee of the Dissolved Shareholder, or Shareholder's

                                       9

<PAGE>

Representative has elected to establish a Voting Trust Agreement, substantially
in the form of Exhibit 1 hereto, under which QVESTOR will be appointed as
Trustee and shall have the right to exercise, in person or by proxy, all of such
Shareholder's voting rights and powers in respect of the Shares registered in
the name of the Trustee, and to take part in or consent to any and all corporate
or shareholder action; and

                    (ii)     Simultaneously with the execution of the Voting
Trust Agreement, or as soon as reasonably practicable thereafter, deposit with
the Trustee, the certificate or certificates for their respective Shares,
together with instruments duly executed for the transfer of their shares to the
Trustee. Pending the delivery of such instruments, each Shareholder hereby
transfers the Shares to the Trustee. The Shares shall be vested in the Trustee
and shall be transferred to the name of the Trustee on the books of the Company,
and the Trustee shall issue and deliver a Certificate to each such personal
representative of the Decedent, Trustee of the Dissolved Shareholder or
Shareholder's Representative representing his beneficial ownership of the
deposited Shares (a "Certificate"); and

                    (iii)  Complete the actions  required by  subsections
(d)(i) and (ii) within ninety (90) days following the notice by the Corporation
or Remaining Shareholders of their election to purchase the Shareholder's
Shares.

         5.       VOTING  AGREEMENT

         Each  of  the  parties  hereto  agrees  to  nominate,   and  cause  the
Corporation to nominate, for election to the Corporation's Board of Directors at
any special or annual meeting of stockholders of the Corporation,  four nominees
proposed by Shareholders QVESTOR and Q-Med, ("Nominees") and each of the parties
hereto agrees to vote, at any special or annual meeting of the  stockholders  of
the Corporation, to elect such Nominees to the Corporation's Board of Directors.

         6.       AGREED VALUE OF SHARES

         The Corporation and the Shareholders stipulate that the Agreed Value of
each  Share  for  purposes  of this  Agreement  shall be the  value set forth on
Schedule  "A"  attached  hereto  from time to time.  The Agreed  Value  shall be
established  not less often than once each calendar year by the  Shareholders at
the Corporation's Annual Meeting and shall be set forth on a new Schedule "A" to
be attached to this  Agreement.  If for any reason the  Shareholders  shall have
failed  to  stipulate  the value for the year in which a  Shareholder  dies,  is
dissolved,  becomes  disabled,  is terminated or announces its intention to sell
its Shares, the last previously stipulated value shall control. In the event the
Shareholders  have failed to stipulate  the value of the Shares for more than 18
months  and the  Agreed  Value of the  Corporation's  Shares is  disputed  by an
Offering Shareholder,  the personal  representative of the deceased Shareholder,
the  trustee(s) of a dissolved  Shareholder  or a Disabled  Shareholder  covered
under this  Agreement  (hereinafter

                                       10

<PAGE>

referred  to  collectively  as the  "Selling  Shareholders"),  the  value of the
Corporation's  Shares will be set by  appraisal.  The Selling  Shareholders,  at
their expense,  shall have the right to choose an MAI appraiser to independently
appraise the business and worth of the  Corporation  as of the date of the event
which created a  requirement  or option to purchase the Shares.  Such  appraisal
shall then be presented to the Board of Directors of the  Corporation  for their
approval.  If a  majority  of the Board  approves  the  amount of the  appraisal
prepared by the Selling  Shareholders'  MAI, such appraisal  shall be deemed the
fair market value of the Corporation  ("FMV") from which the Agreed Value of the
Shares will be determined for purposes of said transaction. Should a majority of
the Corporation's  Board of Directors fail to approve the appraisal  prepared by
the Selling  Shareholders'  MAI, the Board may, at its expense,  choose a second
MAI to independently  appraise the business and worth of the  Corporation.  Once
the Board's MAI has  completed  its  appraisal,  the  appraisals of the two MAIs
shall be  averaged  to  determine  the FMV of the  Corporation  unless  the MAIs
disagree on FMV by an amount  exceeding  ten percent  (10%) of the highest  such
appraisal.  If the difference in the  appraisals  does exceed ten percent (10%),
the two MAIs may  designate a third MAI to perform an  independent  appraisal of
the  company  and  assign  a FMV to its  Shares.  The  cost of the  third  MAI's
appraisal  shall  be  borne  equally  by  the  Selling   Shareholders   and  the
Corporation,  and the FMV determined by such  appraiser  shall be binding on all
parties.  Once the FMV of the Corporation is established in accordance with this
section,  the Agreed Value for said  transaction  will be calculated by dividing
the FMV of the Corporation by the number of shares of Shares  outstanding at the
date when the event  occurred  which created a requirement or option to purchase
the Shares.

         7.       CLOSING

         The  Corporation  shall set a reasonable  time after  acceptance by the
Corporation  and/or  the  other  Shareholders  of  an  offer  from  an  Offering
Shareholder for closing a purchase under this Agreement.

         8.       DELIVERY OF SHARES

         Upon the payment to the  Shareholder  of the purchase price as provided
in this Agreement, the Shareholder shall assign and deliver the Shares purchased
under this Agreement to the  Corporation  (as transfer  agent) free and clear of
all liens, charges, and encumbrances of any nature whatsoever, duly endorsed for
transfer.

         9.       DOCUMENTARY STAMPS

         Whenever any Shares are sold pursuant to this Agreement,  the party who
triggers the sale of Shares must purchase and affix to the Share certificate any
documentary stamps required by Florida law.

                                       11

<PAGE>

         10.      PIGGY-BACK REGISTRATION RIGHTS

         If the  Corporation  elects to  register  any of its  Shares  under the
Securities Act of 1933 and/or  applicable state securities laws, the Corporation
shall provide the  Shareholders  notice of such  election,  and,  subject to the
approval of the lead  underwriter  in any such  registration,  the  Shareholders
shall be entitled to  "piggy-back"  registration  rights for not less than fifty
percent  ) of  their  Shares  at no  expense,  other  than  applicable  broker's
commission.

         11.      DOCUMENTATION

         While  employed  by  the  Corporation,  each  employee  and  consultant
Shareholder shall prepare and maintain adequate and current documentation of his
work for the Corporation.  Upon any termination of such employment, the employee
Shareholder  shall leave  reasonable and orderly  documentation  of his work and
cooperate  fully with the  Corporation  in  connection  with the training of any
person or persons employed to perform the employee  Shareholder's duties and the
orderly and smooth transfer of the employee  Shareholder's duties to such person
or persons.

         12.      TERMINATION OR MODIFICATION OF AGREEMENT

                  (a)    This Agreement will terminate upon the occurrence of
any of the following events:

                         (i)      cessation of the Corporation's business;

                         (ii)     receivership, filing for relief under the
                                  Bankruptcy Code, or dissolution of the
                                  Corporation;

                         (iii)    the written agreement of all parties hereto;

                         (iv) the initial public offering of the  Corporation's
                              shares on a listed stock exchange; or

                         (v)  the  sale  of  all or  substantially  all of the
                              stock  or  assets  of the Corporation.

                  (b) This Agreement may only be modified by the written
agreement of all parties hereto. Unanimous approval of all Shareholders shall be
required for any amendment to be effective.

                                       12

<PAGE>

         13.      ABANDONMENT

         If a  Shareholder  attempts  or  purports  to attempt to Dispose Of its
Shares in violation of this Agreement,  then the Shareholder  shall be deemed to
have abandoned its ownership  interest in its Shares,  and the Corporation shall
be empowered (but not obligated) to redeem such Shareholder's ownership interest
in its Shares.  The redemption price in the event of an abandonment  shall be no
greater  than the  price  paid for the  Shares  by the  abandoning  Shareholder,
without credit or attribution of interest, or the then-current book value of its
Shares,  whichever  sum is less,  said lower  value  being a  disincentive  to a
Shareholder to abandon its interest in its Shares.  The  redemption  price under
this paragraph shall be paid to the abandoning  Shareholder over a period of two
(2)  years  in  annual  installments  beginning  one  year  after  the  date  of
abandonment, with no interest accruing. Each Shareholder which is a party hereto
hereby  irrevocably  constitutes  and  appoints  the  Shareholders  who have not
abandoned their interests in their Shares as its  attorneys-in-fact to terminate
its  ownership  interest in the  Corporation  in the event it shall  abandon its
interest as provided  herein,  and to execute,  file of record,  and record,  as
appropriate, such documents and instruments as may be required to effectuate the
transfer of its ownership interest.

         14.      INABILITY OF CORPORATION TO PURCHASE SHARES

         If the  Corporation  does not have  sufficient  surplus  to  permit  it
lawfully  to  purchase  all of the  Shares as it deems  desirable  hereunder  to
purchase,  the  Shareholders  shall  promptly  take such  measures to vote their
respective  holdings  of Shares to reduce  the  capital of the  Corporation,  to
revalue the capital of the Corporation so as to increase its surplus, or to take
such  other  steps as may be  appropriate  or  necessary  in order to enable the
Corporation lawfully to perform its obligations hereunder,  including, by way of
illustration and not by way of limitation, an up-to-date appraisal of the assets
of the Corporation.

         15.      NONIMPAIRMENT

         In no event shall the  purchase  of a  Shareholder's  Shares  cause the
Corporation's solvency and continuing operations to be impaired. Accordingly, in
the event  insurance  proceeds  (if  obtained  for death of a  Shareholder)  are
insufficient   to  discharge   the   Corporation's   obligation  to  purchase  a
Shareholder's  Shares,  then,   notwithstanding  any  other  provision  of  this
Agreement, the payment of the purchase price of the Shares shall be accomplished
so as not to cause the solvency and continued  operations to be impaired on such
terms  and  conditions  as  the  directors  of the  Corporation  in  good  faith
determine.

                                       13

<PAGE>

         16.      STATUS OF TRANSFEREES

          Except with respect to donees of a Shareholder as set forth in section
3 hereof,  any person or entity acquiring any Share of stock in the Corporation,
by accepting it, shall be deemed to be a party to this Agreement and to agree to
be  subject to all the terms and  conditions  of this  Agreement  as if he or it
signed this  Agreement  as a  Shareholder.  Each such  transferee  shall sign an
agreement joining to this Agreement.

         17.      INDEBTEDNESS OF TRANSFEROR TO CORPORATION

         If the  transferor  of any Shares  sold  hereunder  is  indebted to the
Corporation  at the time the purchase  price for the Shares is to be paid by the
Corporation,  the purchase price paid for such Shares, including any interest or
any deferred payments of such purchase price, shall first be applied against the
outstanding balance of such indebtedness, and the balance of such purchase price
and  interest  shall be paid to the  transferor  of the  Shares  as  hereinabove
provided.

          18.     PURCHASE BY THE CORPORATION

         Whenever the Corporation, pursuant to this Agreement, purchases Shares,
all  Shareholders  shall do all things and execute and deliver all papers as may
be  necessary  to  consummate  such  purchase.  All Shares so  purchased  by the
Corporation shall be cancelled.

          19.     SPECIFIC PERFORMANCE

         The parties  hereby  declare that it is  impossible to measure in money
the  damages  that will  accrue to a part or to the  Shareholder  by reason of a
failure  of a party to perform  any of the  obligations  under  this  Agreement.
Therefore, if the Corporation, any Shareholder, the personal representative of a
Decedent or the trustee(s) of a Dissolved Shareholder shall institute any action
or proceeding to  specifically  enforce the provisions  hereof,  then any person
(including  the  Corporation)  against whom such action or proceeding is brought
hereby  waives the claim or  defense  therein  that such  party has an  adequate
remedy at law, and such person  shall not urge in any such action or  proceeding
the claim or defense  that an adequate  remedy at law exists so as to defeat the
claim for specific performance of this Agreement.

          20.      NOTICES

         Any and all notices,  designations,  consents, offers,  acceptances, or
any other  communication  provided  for herein  shall be given in writing  which
shall  be  addressed  to the  Shareholders  at the  current  address  which  the
Shareholders  have  furnished  to the  Corporation  and  which is on file at the
Corporation's office and to

                                       14

<PAGE>

the Corporation at its principal  office,  or if none, to the last known address
of the addressee,  and shall be deemed given (i) when actually  received by hand
delivery  or express  courier,  or (ii) five (5) days  after  posting by postage
pre-paid certified or registered mail.

          21.      GOVERNING LAW

         This Agreement shall be governed, construed,  interpreted, and enforced
in accordance with the laws of the State of Delaware.

         22.      ARBITRATION/ATTORNEY FEES

         The parties  will attempt in good faith to resolve any  controversy  or
claim  arising out of or relating to this  Agreement by mediation in  accordance
with the Center for Public  Resources  Model Procedure for Mediation of Business
Disputes.

         If the matter has not been resolved pursuant to the aforesaid mediation
procedure  within sixty days of the commencement of such procedure (which period
may be  extend  by  mutual  agreement),  the  controversy  shall be  settled  by
arbitration  in  accordance  with the  Center  for  Public  Resources  Rules for
Non-Administered Arbitration of Business Disputes, by three arbitrators, of whom
each party shall  appoint one. The  arbitration  shall be governed by the United
States  Arbitration Act, 9 U.S.C. ss. 1-16, and judgment upon the award rendered
by the  Arbitrator(s) may be entered by any court having  jurisdiction  thereof.
The place of arbitration shall be Orlando, Florida.

         The prevailing party in such arbitration  shall be entitled to an award
of attorney's fees incurred during the mediation and arbitration.

         23.      BINDING EFFECT

         This  Agreement  will inure to the  benefit of and be binding  upon the
Corporation,  its  successors  and assigns,  including,  but not limited to, any
Corporation  or  entity  that  may  acquire  all  or  substantially  all  of the
Corporation's  assets  and  business  or  into  which  the  Corporation  may  be
consolidated or merged,  and upon the Shareholders,  their successors,  assigns,
heirs,  and legal  representatives,  as the case may be,  and shall bind all who
sign regardless of whether one or more persons who hold Shares fail to sign this
Agreement.

         24.      MULTIPLE COPIES OR COUNTERPARTS OF AGREEMENT.

         The original and one or more copies of this  Agreement  may be executed
  by one or more of the  parties.  In such event,  all of such  executed  copies
  shall have the same force and effect as the executed original, and all of such
  counterparts,  taken  together,  shall  have the  effect  of a fully  executed
  original.

                                       15

<PAGE>

         25.      NO ASSIGNMENT

         This Agreement and a Shareholder's rights hereunder may not be assigned
by a Shareholder to any firm,  entity,  or person  without the express,  written
approval of the Corporation and the other Shareholders.

         26.      INVALID PROVISION

         The invalidity or  unenforceability  of a particular  provision of this
Agreement shall not affect the other provisions  hereof, and the agreement shall
be construed in all respects as if the invalid or unenforceable  provisions were
omitted.

         27.      ENTIRE AGREEMENT

         This Agreement  constitutes the entire  agreement and  understanding of
the parties with respect to the  transfer of the Shares and  supersedes  any and
all prior agreements regarding the Shares, whether written or oral.

         28.      SURVIVAL

                  All sections of this Agreement  shall survive the  termination
of this  Agreement  for any reason as are  necessary to effect the rights of the
parties hereto or of any Trustee appointed hereunder.

         IN WITNESS  WHEREOF,  the  Corporation  and QVESTOR have  executed this
instrument  by  and  through  their  authorized   officers  and  the  individual
Shareholders  have  hereunto  placed their hands on the day and year first above
written.


                                        "CORPORATION":

Witnesses:                              IXION BIOTECHNOLOGY, INC.

              /S/                                       /S/
--------------------------------        By:---------------------------------
Thomas P. Stagnaro                      Weaver Gaines
                                        Chairman and Chief Executive Officer





                                       16
<PAGE>



                                        "Q-MED":

Witnesses:                              Q-MED AB (publ)

               /S/                                         /S/
--------------------------------        By:----------------------------------
 Terence F. Brennan                     Per Olof Wallstrom
                                        President and Chief Executive Officer


              /S/                                          /S/
--------------------------------        By:----------------------------------
 Terence F. Brennan                     Bengt Agerup
--------------------------------        Member of the Board of Directors











                                       17
<PAGE>



                                       "QVESTOR":

Witnesses:                             QVESTOR LLC



              /S/                                      /S/
--------------------------------       By:------------------------------------
Terence F. Brennan                          Per Olof Wallstrom







                                       18
<PAGE>




Witnesses:                              AMMON B. PECK PH.D

               /S/                                      /S/
-------------------------------         ----------------------------------
Theodore Lee Snow                       Ammon B. Peck, Individually

               /S/
-------------------------------
Kimberly A. Ramsey


Witnesses:                              WEAVER H. GAINES

              /S/                                       /S/
-------------------------------         ----------------------------------
Thomas P. Stagnaro                      Weaver H. Gaines, Individually






                                       19
<PAGE>





                                   SCHEDULE A
                                   ----------

                                  Agreed Value
                                  ------------


The Agreed Value for the Shares as of July -----, 2000 is $4.00 per share.

                                           the "CORPORATION":

Witnesses:                                 IXION BIOTECHNOLOGY, INC.


--------------------------------           By:------------------------------
                                           Weaver Gaines
--------------------------------           Chairman and Chief Executive Officer


"Q-MED":

Witnesses:                                 Q-MED AB (publ)



--------------------------------           By:------------------------------
                                           Per Olof Wallstrom
--------------------------------           President and Chief Executive Officer



--------------------------------           By:------------------------------
                                           Bengt Agerup
--------------------------------           Member of the Board of Directors


                                           "QVESTOR":

Witnesses:                                 QVESTOR LLC



--------------------------------           By:------------------------------
                                           Per Olof Wallstrom
--------------------------------


                                       20
<PAGE>




Witnesses:                                 AMMON B. PECK PH.D



-------------------------------            ----------------------------------
                                           Ammon B. Peck, Individually
-------------------------------



Witnesses:                                 WEAVER H. GAINES



-------------------------------            ----------------------------------
                                           Weaver H. Gaines, Individually
-------------------------------


                                       21
<PAGE>

                                   EXHIBIT 1
                                   ---------


                             VOTING TRUST AGREEMENT


     This is a Voting Trust Agreement (the "Agreement") dated as of
----------------, among IXION Biotechnology Inc. ("Company"), -----------------
("Shareholder") and QVESTOR, LLC, a Delaware limited liability company, as
Trustee.

                                   Background

     The Shareholder currently owns ---------- shares of common stock (the
"Shares") of IXION BIOTECHNOLOGY, INC. (the "Company"). Pursuant to section 4(d)
of a Shareholders' Agreement dated July 14, 2000 among the Shareholder, the
Company, and certain other shareholders named therein ("Shareholders
Agreement"), the parties desire to enter into this Agreement regarding the
deposit of the Shares with the Trustee. Accordingly, in consideration of the
mutual covenants and agreements set forth below, the parties agree as follows:

                                      Terms

         1. Filing. A copy of this Agreement and any amendment to this Agreement
shall be filed in the principal office of the Company, and shall be open to the
inspection of any shareholder of the Company. All voting trust certificates (the
"Certificates") issued pursuant to this Agreement shall be issued, received, and
held subject to all the terms of this Agreement. Every person entitled to
receive voting trust certificates under this Agreement, representing shares of
common stock of the Company, and their permitted transferees and assigns, shall
be bound by the provisions of this Agreement.

         2. Appointment of the Trustee. The Trustee shall be QVESTOR, LLC.

         3. Transfer of Stock to Trustee. As soon as reasonably possible after
the execution of this Agreement, the Shareholder will deposit with the Trustee,
the certificate or certificates for the Shares, together with instruments duly
executed for the transfer of the Shares to the Trustee. Pending the delivery of
such instruments, the Shareholder hereby transfers the Shares to the Trustee.
The Shares shall be vested in the Trustee and shall be transferred to the name
of the Trustee on the books of the Company.

         4. Trust Certificates. Following the deposit by the Shareholder of the
certificate or certificates representing their respective Shares with the
Trustee, the Trustee shall issue and deliver a Certificate to the Shareholder
representing his

<PAGE>

beneficial ownership of the Shares (a "Certificate"),  in substantially the form
attached to this Agreement as Exhibit A.

         5.       Rights of Trustee.

                  (a) The Trustee shall have the right to exercise, in person or
by proxy, all of the Shareholder's voting rights and powers in respect of the
Shares registered in the name of the Trustee, and to take part in or consent to
any and all corporate or shareholder action. The right to vote shall include,
without limitation, the right to vote on the election ofdirectors. The Trustee
may in all  matters act either at a meeting or by written  consent.  The parties
acknowledge that the Trustee, for purposes of this Agreement, shall be permitted
to vote the Shares and to exercise  all such powers as are  necessary  for every
legitimate business purpose for the Company. The Trustee shall have no liability
for any actions taken pursuant to this Agreement, except for those actions taken
in bad faith or in willful violation of this Agreement.

                  (b) It is expressly understood and agreed that the Shareholder
or any future holders of Certificates (the "Holders") shall not have any right
with respect to any Shares held by the Trustee to vote, to take part in, to
consent to or in any way control or limit any corporate or shareholders' action.

                  (c) In voting the Shares held pursuant to this Agreement
(either in person or by Proxy), the Trustee shall exercise its reasonable
business judgment and may take such part in the management of the Company's
affairs as it deems appropriate.

                  (d) It is expressly understood and agreed that at any time,
subject to compliance with: (i) all applicable federal and state securities
laws, (ii) all applicable shareholder agreements and (iii) any underwriter
lock-up agreements that a Holder may sell, assign or otherwise transfer any of
the Certificates and may pledge or otherwise encumber the Certificates;
provided, however, the Shares represented by such Certificates shall continue to
be bound by this Agreement and the new Holder shall sign a copy of this
Agreement.

                  (e) The Trustee shall have the right, in its sole discretion
and at any time during the term of this Agreement, to permit any Holder to sell,
assign or otherwise transfer all or any portion of the Shares represented by the
Holder's Certificates free of this Agreement, and this Agreement will continue
in full force and effect with respect to all remaining Shares.

                  (f) It is also expressly understood and agreed that the
Trustee has no rights in the Shares other than the voting rights set forth in
this Agreement. All of the economic benefits of ownership of the Shares remain
vested in the Shareholders. The Trustee may not at any time sell, transfer,
assign, pledge or otherwise encumber any of the Shares without the consent of
the relevant Holders.

                                       2

<PAGE>

         6. Term. This Agreement shall continue in effect for a period extending
until the earlier of (a) July 15, 2010 or (b) the date that the Trustee and
Shareholder agree in writing to terminate this Agreement.

         7.       Termination Procedure.

                  (a) Upon the termination of this Agreement, the Trustee shall
mail written notice of such termination to the registered owners of the
Certificates, at the addresses appearing on the transfer books of the Trustee.
After the date of any such notice, the Certificates shall cease to have any
effect, and the Holders of the Certificates shall have no further rights under
this Agreement other than to receive certificates for shares of stock of the
Company or other property distributable under the terms of this Agreement and
upon the surrender of the Certificates.

                  (b) Promptly following the termination of this Agreement and
the surrender to the Trustee of the Certificates, the Trustee shall take all
actions necessary to have the record ownership of that number of Shares
represented by the Certificates transferred on the books of the Company into the
name of the Holder or the Holder's nominees and shall have the Certificates
representing such Shares delivered to such Holder or the Holder's nominee. The
Trustee shall deliver to each registered Holder, stock certificates for the
number of Shares represented by the Certificate held by such Holder, upon the
surrender of the properly endorsed Certificate.

         8.       Dividends.

                  (a) Prior to the termination of this Agreement the Holders
shall be entitled to receive payments of cash dividends, if any, paid by the
Company upon a like number and class of shares of Common Stock as is represented
by each Certificate. If any dividend or distribution in respect of the Shares
deposited with the Trustee is paid, in whole or in part, in stock of the Company
having general voting powers, the Trustee shall receive and hold, subject to the
terms of this Agreement, the certificates for stock which are distributed on
account of such dividend or distribution and the Holder shall be entitled to
receive a Certificate issued under this Agreement for the number of shares and
class of stock received as such dividend or distribution with respect to the
Shares represented by such Certificate. The Trustee shall have no interest in
such dividend Shares, other than the right to exercise voting rights.

                  (b) If any dividend or distribution in respect of the stock
deposited with the Trustee is paid other than in cash or in capital stock having
general voting powers, then the Trustee shall distribute such dividend or
distribution to the Holders registered as such at the close of business on the
day fixed by the Trustee for taking a record to determine the Holders entitled
to receive such distribution.

                                       3

<PAGE>

Such distribution shall be made to such Holders ratably,  in accordance with the
number of Shares represented by their respective Certificates.

                  (c) The Trustee shall instruct the Company, in writing, to pay
all cash dividends directly to the Holders or their legal representatives.

                  (d) The Company is authorized to report or direct the
reporting of such dividends to federal or state taxing authorities, as required
by law, using the respective taxpayer identification number of each Holder. Each
Holder agrees to provide the Company with such additional information as is
requested by the Company for such purpose.

         9. Dissolution of the Company. In the event of the dissolution or total
or partial liquidation of the Company, whether voluntary or involuntary, to the
extent that any distributions are received by the Trustee, the Trustee shall
distribute any securities, rights, or property, to which the Holders are
entitled, among the registered Holders or their legal representatives in
proportion to their interests, as shown by the books of the Trustee.

         10. Reorganization of Company. In case the Company is merged into or
consolidated with another corporation, or entity, or all or substantially all of
the assets of the Company are transferred to another corporation or entity, then
in connection with such transfer, the term "Company" for all purposes of this
Agreement shall be taken to include such successor corporation or entity, and
the Trustee shall receive and hold as Trustee under this  Agreement any stock of
such successor  corporation  received on account of the ownership,  of the stock
held under this Agreement, prior to such merger, consolidation, or transfer.

         11.      Trustee.

                  (a) The Trustee (and any successor Trustee) may at any time
resign by mailing to the registered Holders a written resignation, to take
effect thirty days thereafter or upon the prior acceptance of the duties of
Trustee by a successor Trustee.

                  (b) The rights, powers, and privileges of the Trustee named
under this Agreement shall be possessed by any successor Trustee, with the same
effect as though such successors had originally been parties to this Agreement.
The word "Trustee" as used in this Agreement, means the Trustee or any successor
Trustee acting under this Agreement.

         12. Notices. To be effective, a notice or other communication required
or permitted by this Agreement must be in writing. All notices and other
communications shall be delivered by overnight courier service or hand delivery.
Communications shall be addressed to the intended recipient at the address

                                       4

<PAGE>

specified below, or to such other address as the intended recipient may have
designated in a writing previously delivered to the sender:

If to the Company:                         If to the Trustee:

IXION BIOTECHNOLOGY, INC.                  QVESTOR
13704 Progress Boulevard, Box 13           c/o The Corporation Trust Company
Alachua, Florida 32615                     1209 Orange Street
                                           Wilmington, DE

                                           With a copy to:

                                           Terence F. Brennan, Esq.
                                           Holland & Knight LLC
                                           P.O. Box 1526
                                           Orlando, FL  32802

If to the Shareholder:


------------------------------
------------------------------
------------------------------

         13. Governing Law and Venue. This Agreement shall be governed by and
construed under the laws of Delaware. Any suit brought to enforce or construe
any provision of this Agreement shall be brought only in the appropriate court
located in Orange County, Florida; provided, however, the Trustee may initiate
an action in any jurisdiction having jurisdiction over the parties to enjoin a
violation of this Agreement.

         14. Entire Agreement. This Agreement, including its exhibits,
constitutes the entire agreement of the parties concerning its subject matter
and supersedes any prior or contemporaneous agreements or understandings among
them, concerning its subject matter.

         15. Amendment. Upon the written consent of the Trustee and Shareholder
any provisions of this Agreement may be amended.

         16. Voting Power. For the purposes of this Agreement, "Voting Power"
related to Shares shall mean the underlying voting power of the Shares.

         17. Counterparts. This agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
shall constitute one and the same instrument.

                                       5

<PAGE>

         IN WITNESS WHEREOF, the parties have executed this Voting Trust
Agreement as of the date first written above.



Date:-------------------------     ------------------------------
                                   Shareholder




                                   QVESTOR, LLC ("Trustee")


Date:-------------------------     By:---------------------------


                                   IXION BIOTECHNOLOGY, INC. ("Company")
                                   13704 Progress Boulevard, Box 13
                                   Alachua, Florida 32615


Date:-------------------------     By:----------------------------




                                        6

<PAGE>


                            EXHIBIT A (to Exhibit 1)
                            ------------------------


                                Trust Certificate
                                -----------------

No. ------                                       --------------- Shares of Stock

         QVESTOR, LLC, the Trustee of the shares deposited under a Voting Trust
Agreement effective ------------------, having received certain shares of IXION
BIOTECHNOLOGY, INC., a Delaware corporation (the "Company"), pursuant to such
Agreement, hereby certifies that ----------------- will be entitled to receive a
certificate for --------------- fully paid --------------- shares of the Company
on the expiration of the Voting Trust Agreement, and in the meantime shall be
entitled to receive payments equal to any dividends that may be collected by the
Trustee upon a like number of such shares held by him under the terms of the
Voting Trust Agreement.

         Neither this certificate, nor the shares of capital stock for which it
is issued, have been registered under the Securities Act of 1933, as amended, or
any applicable state securities laws, and no transfer or assignment of this
certificate or the shares for which it is issued may be made in the absence of
an effective registration statement under such laws or the availability of
exemptions from the registration provisions thereof in respect of such transfer
or assignment.

         This certificate is subject to restrictions on transfer contained in
the Voting Trust Agreement dated as of -------------------, and the Shareholders
Agreement dated July 14, 2000 among the Company, the Shareholder, and certain
other shareholders named therein, including without limitation, all conditions,
rights of first refusal, options, or other restrictions on transfer of the
shares and is transferable only on the books of the undersigned Trustee by the
registered holder in person or by his duly authorized attorney, and the holder
hereof consents that the undersigned Trustee may treat the registered holder
hereof as the trust owner for all purposes, except the delivery of share
certificates, which delivery shall not be made without the surrender hereof.

         IN WITNESS WHEREOF, the undersigned have executed this Voting Trust
Certificate as of this --------- day of -----------------------.


                                  QVESTOR, LLC



                                  By:--------------------------




                                       7





© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission