IXION BIOTECHNOLOGY INC
8-K, EX-2.1, 2000-07-28
PHARMACEUTICAL PREPARATIONS
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                            STOCK PURCHASE AGREEMENT



                            Dated as of July 14, 2000



                                  By and Among





                                  QVESTOR, LLC
                                (the "Purchaser")



                                      and




                             IXION BIOTECHNOLOGY, INC.
                                 (the "Company")





<PAGE>



                                TABLE OF CONTENTS
                                -----------------




ARTICLE I PURCHASE OF THE STOCK.............................................1

   1.1    Purchase of the Stock.............................................1
   1.2    Purchase Price and Method of Payment..............................1

ARTICLE II REPRESENTATIONS AND WARRANTIES OF THE COMPANY....................2

   2.1    Valid Corporate Existence; Qualification..........................2
   2.2    Capitalization....................................................2
   2.3    No Subsidiaries...................................................3
   2.4    Consents..........................................................3
   2.5    Corporate Authority; Binding Nature of Agreement; Title
                to the Stock, etc.                                       ...3
   2.6    Financial Statements..............................................3
   2.7    Liabilities.......................................................4
   2.8    Actions Since Balance Sheet Date..................................4
   2.9    Absence of Material Changes.......................................5
   2.10   Taxes.............................................................5
   2.11   Ownership of Assets; Intellectual Property, etc...................5
   2.12   Insurance.........................................................6
   2.13   Litigation, Compliance with Laws..................................6
   2.14   Real Property.....................................................7
   2.15   Agreements and Obligations, Performance...........................7
   2.16   Condition of Assets...............................................8
   2.17   Accounts and Notes Receivable.....................................8
   2.18   Permits and Licenses..............................................8
   2.19   Banking Arrangements..............................................8
   2.20   Interest in Assets................................................8
   2.21   Salary Information................................................9
   2.22   Employee Benefit Plans............................................9
   2.23   Brokers...........................................................9
   2.24   Labor Discussions.................................................9
   2.25   Change of Name....................................................9
   2.26   Untrue or Omitted Facts..........................................10
   2.27   Accountant Letters...............................................10

ARTICLE III REPRESENTATIONS AND WARRANTIES OF PURCHASER....................10

   3.1    Valid Corporate Existence; Qualification; Consents...............10
   3.2    Corporate Authority; Binding Nature of Agreement.................10
   3.3    No Breach........................................................11
   3.4    Brokers..........................................................11
<PAGE>


   3.5    Litigation; Compliance with Laws.................................11
   3.6    Untrue or Omitted Facts..........................................12
   3.7    Private Placement................................................12

ARTICLE IV COVENANTS.......................................................13

   4.1    Pre-Closing Covenants of the Company.............................13

ARTICLE V CONDITIONS PRECEDENT TO THE OBLIGATION OF THE PURCHASER
TO CLOSE...................................................................14

   5.1    Representations and Warranties...................................15
   5.2    Covenants........................................................15
   5.3    No Actions.......................................................15
   5.4    Consents; Licenses and Permits...................................15
   5.5    No Material Change...............................................15
   5.6   Certificate.......................................................15
   5.7   Opinion...........................................................15
   5.8   Employment and Director's Agreement...............................16
   5.9   Lease Agreements..................................................16
   5.10  Deferred Compensation.............................................16
   5.11  Additional Documents..............................................17

ARTICLE VI CONDITIONS PRECEDENT TO THE  OBLIGATION OF THE COMPANY TO CLOSE.17

   6.1    Representations and Warranties...................................17
   6.2    Covenants........................................................17
   6.3    No Actions.......................................................17
   6.4    Consents.........................................................17
   6.5    Certificate......................................................18
   6.6    Side Letter......................................................18
   6.7   Additional Documents..............................................18

ARTICLE VII CLOSING........................................................18

   7.1    The Closing......................................................18
   7.2    Location, Time and Date..........................................18
   7.3    Conditions of Closing............................................18
   7.4    Items to be Delivered by the Company.............................19
   7.5    Items to be Delivered by Purchaser...............................19
   7.6    Transfer of Possession...........................................19

ARTICLE VIII SURVIVAL OF REPRESENTATIONS; INDEMNIFICATION..................20

   8.1    Survival.........................................................20
   8.2    Indemnification by the Company...................................20
<PAGE>

   8.3    Indemnification by the Purchaser.................................20
   8.4    Limitations of Liability.........................................21
   8.5    Defense of Claims................................................22

ARTICLE IX TERMINATION AND WAIVER..........................................22

   9.1    Termination......................................................22
   9.2    Waivers..........................................................23

ARTICLE X MISCELLANEOUS PROVISIONS.........................................23

   10.1   Expenses.........................................................23
   10.2   Confidential Information.........................................23
   10.3   Modification, Termination or Waiver..............................24
   10.4   Publicity........................................................24
   10.5   Notices..........................................................24
   10.6   Binding Effect and Assignment....................................25
   10.7   Entire Agreement.................................................25
   10.8   Exhibits.........................................................26
   10.9   Governing Law; CPR; Arbitration..................................26
   10.10     Section Headings..............................................26
   10.11     Gender........................................................26
   10.12     Severability..................................................26
   10.13     Attorneys'Fees................................................26
   10.14     Counterparts..................................................27
   10.15     Recitals......................................................27
   10.16     Definition of Knowledge.......................................27
   10.17     Benefits to Others............................................27



<PAGE>



                            STOCK PURCHASE AGREEMENT
                            ------------------------



     THIS STOCK  PURCHASE  AGREEMENT  (this  "Agreement"),  dated as of July 14,
2000,  by and among  Ixion  Biotechnology,  Inc.,  a Delaware  corporation  (the
"Company") and QVESTOR LLC, a Delaware limited liability company, ("Purchaser").

                              W I T N E S S E T H:
                              --------------------


     WHEREAS, the Purchaser desires to acquire from the Company, and the Company
desires  to issue  and to sell or to cause to be  transferred  to the  Purchaser
3,337,500  shares of the  Company's  $.01 par value common  stock (the  "Company
Common Stock") pursuant to the terms of this Agreement;

     NOW,  THEREFORE,  in  consideration  of the mutual  benefits  to be derived
hereby,  the  representations,  warranties,  covenants,  and  agreements  herein
contained,   and  other  good  and  valuable  consideration,   the  receipt  and
sufficiency  of which is hereby  acknowledged,  the Purchaser and the Company do
hereby agree as follows:


                                   ARTICLE I
                                   ---------

                              PURCHASE OF THE STOCK
                              ---------------------


     1.1 Purchase of the Stock. Upon the terms and subject to the conditions set
forth in this Agreement and in the Shareholders'  Agreement dated as of July 14,
2000  attached  hereto as Exhibit 1.1 hereto  ("Shareholders'  Agreement"),  the
Purchaser  hereby  agrees to acquire  from the Company,  and the Company  hereby
agrees to issue and to sell to the Purchaser at the Closing  3,337,500 shares of
the Company Common Stock (the "Purchased Stock.")


     1.2  Purchase  Price  and  Method of  Payment.  The cash  component  of the
purchase  price shall be two dollars per share of Purchased  Stock,  for a total
purchase  price of $6,675,000 to be paid for the Purchased  Stock (the "Purchase
Price"),  and the  method  payment  of the same  shall  be as set  forth in this
Section 1.2.

 <PAGE>

     (a) Initial Disbursement.  At the Closing, the Purchaser shall a portion of
the Purchase  Price to the Company in the amount of  $3,321,697  dollars by wire
transfer to a bank account to be  designated  in writing by the Company prior to
Closing.

     (b)  Disbursement of Balance of the Purchase Price. The Purchaser shall pay
the  balance of the cash  Purchase  Price not later  than July 14,  2001 by wire
transfer to such bank account.


                                   ARTICLE II
                                   ----------

                         REPRESENTATIONS AND WARRANTIES
                         ------------------------------
                                 OF THE COMPANY
                                 --------------


         The Company makes the following  representations  and warranties to the
Purchaser,  each of which  shall be  deemed  material  (and  the  Purchaser,  in
executing, delivering, and consummating this Agreement, has relied and will rely
upon  the  correctness  and  completeness  of each of such  representations  and
warranties):

     2.1  Valid  Corporate  Existence;   Qualification.   The  Company  is  duly
organized,  validly existing and in good standing under the laws of the State of
Delaware.  The Company has the corporate power to carry on its businesses as now
conducted  and to own its  assets.  The  Company  is duly  qualified  to conduct
business and is in good standing as a foreign corporation in those jurisdictions
set forth on  Schedule  2.1 and in those  jurisdictions  in which the Company is
required to qualify in order to own its assets or  properties or to carry on its
businesses as now conducted,  except where the failure to qualify would not have
a material  adverse effect on the business of the Company taken as a whole,  and
there has not been any claim by any other  jurisdiction  to the effect  that the
Company is required to qualify or  otherwise be  authorized  to do business as a
foreign  corporation   therein.  The  copies  of  the  Company's  good  standing
certificates or certificates of existence (issued by the appropriate authority),
Certificate  of  Incorporation  (certified  by the  appropriate  authority)  and
By-Laws  (certified by the Secretary),  as amended to date,  which  constitute a
part of Schedule 2.1 are true and complete  copies of those  documents as now in
effect. The minute books of the Company contain accurate records of all meetings
of its Boards of Directors and stockholders since the date of incorporation, and
accurately reflect all material  transactions  referred to therein.  At Closing,
all such minute books and records will be in the possession of the Company.

     2.2 Capitalization.  As of the Closing, after the issuance of the Purchased
Stock and the shares of Company Common Stock referred to Section 5.11 below: (i)
the  authorized  capital stock of the Company  consists of 20,000,000  shares of
Common Stock  ("Authorized  Common Stock"),  of which  6,773,653  shares will be
issued  and  outstanding  ("Issued  Common  Stock")  and one  million  shares of
Preferred  Stock,  none of which has been issued or is  outstanding  ("Preferred
Stock");  (ii ) all of such Issued  Common Stock will have been duly authorized,
validly issued, fully paid, and nonassessable;  (iii) except as set forth on
Schedule 2.2, there are no subscriptions, options, warrants, rights, or calls or
other commitments or agreements to which

                                       2

<PAGE>
the Company is a party, calling for the issuance,  transfer, sale, or other
disposition  of any class of securities  of the Company;  and (iv) except as set
forth on Schedule  2.2,  the Company has no class of  securities  other than the
Company  Common Stock and the  Preferred  Stock and the Company has never issued
any  securities  convertible or  exchangeable,  actually or  contingently,  into
shares of the Company Common Stock, or any other securities of the Company.

     2.3 No  Subsidiaries.  Except as set forth on  Schedule  2.3,  there are no
corporations, partnerships, or other business entities controlled by the Company
(collectively,  "Subsidiaries").  As used herein,  "controlled by" means (a) the
ownership of not less than fifty percent (50%) of the voting securities or other
interests of a corporation,  partnership,  or other business entity,  or (b) the
possession,  directly  or  indirectly,  of the  power to  direct  or  cause  the
direction of the management and policies of a corporation, partnership, or other
business entity,  whether through the ownership of voting shares, by contract or
otherwise.  The Company has not made any  investment  in, and does not own,  any
capital stock of, or any other proprietary  interest in, any other  corporation,
partnership  or other  business  entity that is not  reflected  on its books and
records.

     2.4 Consents.

         Except  as  set  forth  on  Schedule  2.4,  there  are no  consents  of
governmental  or other  regulatory  agencies,  foreign or  domestic  or of other
parties  required  to be  received  by or on the part of  Company  to enable the
Company to enter into and carry out this Agreement in all material respects.

     2.5 Corporate Authority;  Binding Nature of Agreement;  Title to the Stock,
etc. The Company has the power to enter into this Agreement and to carry out its
obligations  hereunder.  At the Closing, the Company's execution and delivery of
this Agreement and the consummation of the transactions contemplated hereby will
have been duly  authorized  by the Company's  Board of  Directors,  and no other
corporate  proceeding  on the part of the Company is necessary to authorize  the
execution  and  delivery  of  this  Agreement  and  the   consummation   of  the
transactions  contemplated  hereby.  This  Agreement  constitutes  the valid and
binding agreement of the Company and,  assuming that this Agreement  constitutes
the legal,  valid,  and binding  agreement of the  Purchaser,  is enforceable in
accordance  with its terms  subject to  applicable  bankruptcy,  reorganization,
insolvency  and similar laws  affecting  the rights of creditors  and subject to
general principles of equity.

     2.6 Financial  Statements.  The financial statements of the Company for the
last  three  (3)  fiscal  years  ended  December  31,  1997,   1998,  and  1999,
respectively,  and the interim financial  statements of the Company for the five
month fiscal period ended May 31, 2000  (collectively  "Financial  Statements"),
copies of which are attached  hereto as Schedule 2.6,  taken as a whole,  fairly
present the  financial  position of the Company as of such dates and the results
of its operations for such fiscal years and fiscal periods (subject, in the case
of unaudited interim statements, to normal year-end audit adjustments which will
not be  material  in amount or effect  to the  Company  taken as a whole),  and;
except as set forth  therein or in  Schedule  2.6,  and  except for the  interim
financial statements, were prepared in conformity with generally accepted

                                       3

<PAGE>
accounting  principles ("GAAP") consistently applied throughout the fiscal years
and fiscal period covered thereby.

     2.7 Liabilities. As at May 31, 2000 (the "Balance Sheet Date"), the Company
had no material debts, liabilities or obligations,  contingent or absolute, that
would  be  required  by  GAAP  to be  reflected  on the  books  of  the  Company
(including,  without  limitation,  any contingent tax  liabilities),  other than
those debts,  liabilities and obligations  reflected or reserved  against in the
Company's  unaudited  balance sheet dated May 31, 2000 ("Balance  Sheet") at the
Balance Sheet Date or as set forth on Schedule 2.7.

     2.8  Actions  Since  Balance  Sheet  Date.  Except as  otherwise  expressly
provided  or set forth in the  Financial  Statements  or  Balance  Sheet,  or as
required by this  Agreement,  or as set forth in Schedule 2.8, since the Balance
Sheet Date,  the Company has not: (a) issued or sold, or agreed to issue or sell
any of its capital stock,  options,  warrants,  rights or calls to purchase such
stock,  any securities  convertible or  exchangeable  into such capital stock or
other   corporate   securities,   or   effected   any   subdivision   or   other
recapitalization   affecting  its  capital  stock;  (b)  incurred  any  material
obligations  or  liabilities,  except  those  arising in the  ordinary and usual
course of its  business,  that would  normally be  reflected on the books of the
Company;  (c) incurred any material contingent  obligation or liability,  except
those arising in the ordinary and usual course of its business;  (d)  discharged
or satisfied any lien or encumbrance, except in the ordinary and usual course of
business, or paid or satisfied any liability, absolute or contingent, other than
liabilities  as at the Balance  Sheet Date in the  ordinary  and usual course of
business;  (e) made any wage or salary  increases  or granted any bonuses  other
than wage and salary increases and bonuses granted in accordance with its normal
salary increase and bonus policies;  (f) mortgaged,  pledged or subjected to any
lien or other  encumbrance any of its properties or assets,  or permitted any of
its property or assets to be subjected to any lien or other encumbrance,  except
in the ordinary and usual course of business;  (g) sold, assigned or transferred
any of its  properties  or assets,  except in the  ordinary  and usual course of
business or as approved by Purchaser  in writing;  (h) entered into any material
transaction  not in the ordinary  and usual  course of business;  (i) waived any
rights of material value, or canceled,  modified or waived any  indebtedness for
borrowed  money held by it, except in the ordinary and usual course of business;
(j)  except in the  ordinary  and usual  course  of  business  made any loans or
advances to any person, or assumed,  guaranteed, or otherwise become responsible
for the obligations of any person; or (k) incurred any indebtedness for borrowed
money  (except  for  endorsement,   for  collection  or  deposit  of  negotiable
instruments  received in the  ordinary  and usual  course of  business).  To the
extent that any moneys are outstanding  under any line of credit of the Company,
all such funds were utilized in the ordinary and usual course of business. Since
the  Balance  Sheet Date the Company has not  declared,  paid,  or set aside any
dividends (other than normal recurring  dividends paid in the ordinary course of
business and in the same  proportions as the prior year) or other  distributions
or payments  on its capital  stock,  or  redeemed or  repurchased,  or agreed to
redeem or repurchase, any shares of its capital stock.

     2.9 Absence of Material Changes.  Except as otherwise expressly provided or
set forth in the Financial  Statements or Balance Sheet,  or as required by this
Agreement,  or as set forth in  Schedule  2.9,  there has not been any  material
change,  whether or not  adverse,  in the  assets,

                                       4

<PAGE>
properties,  operations,  or financial condition of the Company.  Since the
Balance Sheet Date, no event has occurred,  other than in the ordinary and usual
course of business and as set forth in such Schedule 2.9, that reasonably  could
be expected to have a material effect upon the business of the Company,  and the
Company does not know of any  development or threatened  development of a nature
that will have, or which could be reasonably expected to have, a material effect
upon  the  business  of the  Company  or  upon  any of its  assets,  properties,
operations or financial condition.

     2.10 Taxes.  Each of the Company's  federal  income tax returns for each of
the fiscal  years ending  December 31, 1997 and 1998 was prepared in  conformity
with the  Financial  Statements  and/or  Balance  Sheet.  Except as set forth in
Schedule 2.10,  all taxes,  including,  without  limitation,  income,  property,
sales, use, franchise,  capital stock,  excise,  added value,  employees' income
withholding,  social  security  and  unemployment  taxes  imposed  by the United
States,  any state, or any foreign  country,  or by any other taxing  authority,
which have become due or payable by the Company,  and all interest and penalties
thereon,  whether disputed or not, have been paid in full or adequately provided
for by reserves,  including  deferred  taxes  computed in accordance  with GAAP,
shown in its books of account;  all  deposits  required by law to be made by the
Company with respect to estimated income, franchise,  sales, use, and employees'
withholding taxes have been duly made; and all tax returns,  including estimated
tax returns,  required to be filed have been duly filed.  Except as set forth in
Schedule  2.10, the federal and state income tax returns of the Company have not
been audited within the three years preceding the Closing Date.

     2.11 Ownership of Assets; Intellectual Property, etc.

     (a)  Except  as set  forth  in  Schedule  2.11,  the  Company  owns and has
exclusive,  good,  and,  marketable  title  to all of  its  assets,  properties,
Intellectual  Property (as defined below), and businesses  (including all assets
reflected in the Balance Sheet,  except as the same may have been disposed of in
the ordinary course of business since the Balance Sheet Date), free and clear of
all liens,  mortgages,  pledges,  conditional sales agreements,  restrictions on
transfer,  or other  encumbrances  or changes.  Such assets,  together with such
additional  assets as the Company  leases or licenses  from others,  are, in the
reasonable business judgment of the Company, sufficient to permit the Company to
conduct its business as now conducted.

     (b)  Schedule  2.11 sets  forth a true and  complete  list of all  patents,
copyrights,  trademarks, and trade names that are either owned by the Company or
in which it has an  interest  as owner or  licensee  ("Intellectual  Property").
Except as set forth in said Schedule 2.11: (i) no other person or entity has any
proprietary  or  other  interest  in any  such  Intellectual  Property  and such
Intellectual  Property  so owned or  licensed  is,  in the  reasonable  business
judgment  of the  Company,  sufficient  to permit the  Company  to  conduct  its
business  as now  conducted;  (ii) the Company is not a party to or bound by any
license  or  agreement  requiring  the  payment  to any  person or entity of any
royalty; (iii) the Company does not know, or have reasonable grounds to

                                       5

<PAGE>

know, of any  infringement  by others of the  Intellectual  Property of the
Company; and (iv) to the knowledge of the Company, the Company is not infringing
upon any patent, copyright,  trade name or trademark, or otherwise violating the
rights of any third party with respect  thereto,  and no  proceedings  have been
instituted  or are  threatened  and no claim has been  received  by the  Company
alleging any such violation.

         (c) To the best of the Company's knowledge, based on preliminary patent
  searches conducted by the Company and its counsel prior to filing applications
  for any of the Company's  patents,  and further based on such patent  searches
  and other disclosure of prior art that the Company  discovered,  or which were
  called  to  its  attention  or to the  attention  of its  counsel  during  the
  prosecution of any of the Company's patent  applications,  there is no generic
  patent that would prevent the development of the Company's  diabetes-related
  technology and Intellectual Property.

     2.12 Insurance.  All of the Company's policies of fire, liability and other
forms of insurance,  except as set forth in Schedule  2.12: (i) are presently in
effect,  and all  premiums  have been  timely  paid;  and (ii) are carried on an
"occurrence  basis." Except as set forth in said Schedule 2.12, the Company does
not know of any state of facts,  or of the  occurrence  of any event which might
reasonably (i) form the basis for a valid claim for any material damages against
the  Company  not fully  covered  by  insurance;  or (ii)  result in a  material
increase in insurance  premiums of the Company on a retroactive  or  prospective
basis;  or (iii) give rise to any claim which an employee  may have  against the
Company that is not fully covered by insurance  (including any medically related
illness).

     2.13 Litigation, Compliance with Laws.

         (a) Except as set forth in  Schedule  2.13,  there are no  actions,
suits, proceedings,  or governmental investigations relating to the Company or
to any of its properties,  assets,  Intellectual Property, or business, filed or
commenced and pending or, to the knowledge of the Company, threatened, or any
order, injunction, award, or decree outstanding,  against the Company or against
or  relating  to  any of  its  properties,  assets,  Intellectual  Property,  or
business; and the Company does not know of any basis for any such action, suits,
or proceedings  within the past two years which could  reasonably be expected to
have  a  material  adverse  effect  on the  business,  financial  condition,  or
operations of the Company.

         (b) Except as set forth in  Schedule  2.13,  there are no  pending
claims, investigations, charges, citations, hearings, consents, decrees, or
litigation pending,  or to the knowledge of the Company,  threatened against the
Company with respect to wages, compensation,  bonuses, commissions, or awards or
payroll deductions;  equal employment or human rights violations regarding race,
color,  religion,  sex, national origin, age, veteran's status,  marital status,
disability,  or any  other  recognized  attribute  under  any  applicable  equal
employment law of any federal, state, or municipal government entity prohibiting
discrimination.

     2.14 Real  Property.  Schedule 2.14 sets forth a brief  description  of all
real properties which are leased to, owned, or utilized by the Company including
all material  structures  located

                                      6

<PAGE>
thereon (the  "Structures") and are subject to the transactions  contemplated by
this Agreement (collectively, the "Property"). To the knowledge of the Company:

                 (a)  All  uses of all of  such  Property  by the  Company
conform,  in  all  material  respects,   to  all  applicable   building,   fire,
environmental,  and zoning ordinances,  laws, codes, and regulations (including,
without limitation,  the Americans' with Disabilities Act) and, to the knowledge
of the Company and the Company, to all terms of the leases relating thereto;

                 (b) Except as otherwise  described in Schedule  2.14,  all of
the Property is in usable and operating  condition without the necessity of any
major repairs,  and all such real properties can be used for their intended
purposes;

     2.15 Agreements and Obligations,  Performance. Except as listed and briefly
described in Schedule  2.15 (the "Listed  Agreements"),  as of the Closing Date,
the  Company  is not a party  to,  nor is  bound  by any:  (a)  written  or oral
contract, arrangement,  commitment, or understanding (collectively,  "Contract")
which Contract  involves  aggregate  payments in excess of Ten Thousand  Dollars
($10,000)  and which  Contract  cannot be  canceled  on thirty (30) days or less
notice without penalty or premium or any continuing obligation or liability; (b)
contractual  obligation or contractual  liability of any kind to the officers or
directors of the Company;  (c) deferred  compensation bonus or incentive plan or
agreement not  cancelable at will without  penalty or premium or any  continuing
obligation or liability;  (d) contract containing covenants limiting the freedom
of the  Company to engage or compete in any line of  business or with any person
in  any  geographical  area,  except  for   manufacturer's   representatives  or
distribution  agreements;  (e) contract or option relating to the acquisition or
sale of any  business;  (f) voting  trust  agreement  or  similar  stockholders'
agreement;  or (g) other Contract which materially and adversely  affects any of
its properties,  assets, or business,  whether directly or indirectly,  or which
was entered into other than in the ordinary course of business. The Company has
in all material respects  performed all obligations  required to be performed by
it to date under all of the Listed Agreements, is not in default in any material
respect  under  any of the  Listed  Agreements  or  under  any  other  contract,
commitment,  or  understanding,  and has  received  no notice of any  default or
alleged  default  hereunder  which has not heretofore been cured or which notice
has not  heretofore  been  withdrawn.  The Company does not know of any material
default under any of the Listed  Agreements by any other party thereto or by any
other person, firm or corporation bound thereunder.

     2.16 Condition of Assets.  Except as set forth on Schedule 2.16, and except
for normal  breakdowns and servicing  requirements,  all machinery and equipment
and laboratories  (collectively  "Assets")  regularly used by the Company in the
conduct of its business has been  maintained and repaired in accordance with the
Company's  maintenance  standards  for  such  Assets  and all  such  are in good
operating condition.

     2.17 Accounts and Notes Receivable.

Except as set forth on Schedule 2.17,  all of the accounts and notes  receivable
reflected  in the  Financial  Statements  of the Company  were or will have been
created in the  ordinary  course of its  business,  from the sale of services or
goods, and the Company does not know of any valid

                                      7

<PAGE>
defense  or right of  set-off  to the  rights of the  Company  to  collect  such
accounts receivable in the full amounts shown.

     2.18  Permits  and  Licenses.  Except as set forth in  Schedule  2.18,  the
Company has all permits,  licenses,  orders,  franchises,  and  approvals of all
federal,  state,  local, and foreign  governmental or regulatory  bodies,  whose
failure to be held would materially and adversely  affect the Company's  ability
to carry on its  business as presently  conducted  and such  permits,  licenses,
orders, franchises and approvals are in full force and effect, and no suspension
or cancellation of any of such other permits,  licenses,  etc., is pending or to
the knowledge of the Company threatened; and the Company is in compliance in all
material  respects  with all  requirements,  standards,  and  procedures  of the
federal,  state,  local, and foreign  governmental bodies which have issued such
permits, licenses, orders, franchises, and approvals.

     2.19 Banking  Arrangements.  Schedule 2.19 sets forth the name of each bank
in or with which the Company has an account, credit line or safety deposit box.

     2.20 Interest in Assets.  Except as set forth in Schedule 2.20, none of the
officers,  directors,  or  shareholders,  or  any  affiliate  thereof,  own  any
Intellectual Property or other proprietary rights, tangible or intangible,  used
in or related,  directly or indirectly,  to the business of the Company. As used
herein, "affiliate" means any person,  corporation,  or other entity (other than
the Company) which directly or indirectly controls, is controlled by or is under
common control with any officer, director or shareholder.

     2.21 Salary  Information.  Schedule  2.21  contains a list of the names and
current  salary  rates of and bonus  commitments  to all  present  officers  and
directors of the Company.

     2.22 Employee Benefit Plans.  Other than as set forth on Schedule 2.22, (i)
there are no "employee  pension  benefit  plans"  (within the meaning of Section
3(2)(A) of the  Employee  Retirement  Income  Security  Act of 1974,  as amended
("ERISA"))  maintained  by the  Company,  and (ii) the Company does not have any
policies or plans,  whether written or not, that provide for vacation  benefits,
severance benefits, leave rights, or other benefits to its employees. .

     Except as otherwise set forth in Schedule 2.22 hereto, the Company does not
have a Company Employees' (401(k)) Profit Sharing Plan .

     2.23  Brokers.  Except as  described  in Schedule  2.23,  all  negotiations
relative to this Agreement and the  transactions  contemplated  hereby have been
carried on directly  with the  Purchaser or an affiliate  thereof by the Company
without the  intervention of any broker,  finder,  investment  banker,  or other
third party.  Except as described in Schedule 2.23, the Company has not engaged,
consented to, or authorized  any broker,  finder,  investment  banker,  or other
third party to act on its behalf, directly or indirectly,  as a broker or finder
in connection with the  transactions  contemplated  by this  Agreement,  and the
Company agrees to indemnify the Purchaser against,  and to hold it harmless from
any claim for brokerage or similar commission or other compensation which may be
made  against  the  Purchaser  by  any  third  party  in  connection   with  any
transactions  contemplated  hereby  which  claim is based upon any action by the
Company.

                                       8

<PAGE>
     2.24 Labor  Discussions.  Except with respect to the  agreements  listed in
Schedule  2.24,  the  Company  is  not,  nor has it ever  been,  a party  to any
agreement,  collective  bargaining  or otherwise,  with any party  regarding the
rates  of pay or  working  conditions  of any of the  Company's  employees,  nor
obligated   under  any   agreement  to  recognize  or  bargain  with  any  labor
organization or union,  nor involved in any labor  discussions  with any unit or
group seeking to become the bargaining unit for any of its employees.

     2.25 Change of Name. The Company has not conducted  business under any name
during the past five years except those set forth on Schedule 2.25.

     2.26 Untrue or Omitted Facts. No  representation,  warranty,  covenant,  or
statement by the Company in this  Agreement  contains any untrue  statement of a
material  fact,  or  fails  to state a fact  necessary  in  order  to make  such
representation,  warranty,  covenant,  or statements not materially  misleading.
Without limitation of the foregoing, there is no fact known to the Company or to
the Company's  officers,  managers,  or directors  that has had, or which may be
reasonably  expected to have, a material adverse effect on the Company or any of
its  assets,  properties,  operations,  or  businesses  and  that  has not  been
disclosed in writing to the Purchaser.

     2.27 Accountant Letters.  Within the past five fiscal years of the Company,
the Company has not received any correspondence with its accountants,  including
without limitation,  management letters,  which have indicated or disclosed that
there is a "material weakness" in or "reportable  condition" with respect to (as
those terms are defined under GAAP) the Company's financial condition.


                                  ARTICLE III
                                  -----------

                   REPRESENTATIONS AND WARRANTIES OF PURCHASER
                   -------------------------------------------


     The Purchaser makes the following representations and warranties to the
Company,  each of which shall be deemed material (and the Company, in executing,
delivering,  and consummating this Agreement, have relied and will rely upon the
correctness and completeness of each of such representations and warranties):

     3.1 Valid Corporate Existence; Qualification;  Consents. The Purchaser is a
limited liability company duly organized,  validly existing and in good standing
under the laws of the State of Delaware. The Purchaser has the power to carry on
its  business as now  conducted  and to own its  assets.  Except as set forth in
Schedule  3.1,  there  are no  consents  of  governmental  or  other  regulatory
agencies, foreign or domestic, or of other parties required to be received by or
on the part of the Purchaser to enable the Purchaser to enter into and carry out
this Agreement in all material respects.

     3.2 Corporate Authority; Binding Nature of Agreement. The Purchaser has the
power to enter into this Agreement and to carry out its obligations  thereunder.
The  execution  and  delivery  of this  Agreement  and the  consummation  of the
transactions  contemplated  hereby have been duly

                                      9

<PAGE>

authorized by the Purchaser's Members and no other proceeding on the part of the
Purchaser or any  affiliate  will be necessary to authorize  the  execution  and
delivery of this Agreement and the consummation of the transactions contemplated
hereby.  This  Agreement  constitutes  the valid and  binding  agreement  of the
Purchaser and,  assuming that this Agreement  constitutes  the legal,  valid and
binding  agreement of the other parties,  is enforceable in accordance  with its
terms subject to applicable bankruptcy,  insolvency,  and similar laws affecting
the rights of creditors and subject to general principles of equity.

     3.3 No Breach.  Neither the  execution  and delivery of this  Agreement nor
compliance  by  the  Purchaser  with  any  of  the  provisions  hereof  nor  the
consummation of the transactions contemplated hereby, will:

              (a) violate or conflict with any provisions of the Articles of
Organization or Operating Agreement of the Purchaser;

              (b) violate or, alone or with the passage of time, result in the
material breach or termination  of, or otherwise give any contracting  party the
right to terminate,  or declare a default  under,  the terms of any agreement or
other document or undertaking, oral or written to which the Purchaser is a party
or by which it or any of its  properties or assets may be bound (except for such
violations,  conflicts,  breaches or defaults  as to which  required  waivers or
consents by other parties have been, or will, prior to Closing, be, obtained);

              (c) result in the creation of any lien, security interest, charge
or encumbrance upon any of the properties or assets of the Purchaser or pursuant
to the terms of any such agreement or, instrument;

              (d) violate any judgment, order, injunction, decree or award
against, or binding upon the Purchaser or upon its properties or assets; or

              (e) violate any law or regulation of any jurisdiction  relating to
the Purchaser or any of its securities, assets or properties.

     3.4 Brokers. Neither the Purchaser nor any affiliate has engaged, consented
to, or authorized any broker, finder, investment banker, or other third party to
act on its behalf,  directly or indirectly,  as a broker or finder in connection
with the transactions  contemplated by this Agreement,  and the Purchaser agrees
to indemnify the Company  against,  and to hold it harmless  from, any claim for
brokerage or similar  commission or other compensation which may be made against
the  Company  or  the  Company  by  any  third  party  in  connection  with  the
transactions  contemplated  hereby,  which claim is based upon any action by the
Purchaser or any affiliate.

     3.5  Litigation;  Compliance  with  Laws.  There  are  no  actions,  suits,
proceedings or governmental  investigations  relating to the Purchaser or any of
its  subsidiaries  or  affiliates  filed or  commenced  and  pending  or, to the
knowledge  of the  Purchaser,  threatened,  or any order,  injunction,  award or
decree  outstanding  against  the  Purchaser  or  any  of  its  subsidiaries  or
affiliates;  the Purchaser is not in material violation of any law,  regulation,
ordinance,  order,  injunction,  decree,  award,  or  other  requirement  of any
governmental body, court, or arbitrator

                                       10

<PAGE>

relating to its securities, businesses, properties, or assets which could have a
materially adverse effect on the business,  financial  condition or operation of
the Purchaser.

     3.6 Untrue or Omitted Facts. No representation,  warranty,  or statement by
the  Purchaser in this  Agreement  contains  any untrue  statement of a material
fact,  or omits or will  omit to state a fact  necessary  in order to make  such
representations, warranties, or statements not materially misleading.

     3.7 Private Placement.

     (a) The  Purchased  Shares are being  acquired by Purchaser for its own
account for investment and not with a view of the resale or  distribution  there
of,  and  Purchaser  has no present  intention  of making  any  distribution  or
disposition  of any of such Purchased  Shares.  Purchaser  understands  that the
Purchased  Shares  are being  sold in a  transaction  which is  exempt  from the
registration  requirements  of the Securities Act of 1933 (the "Act"),  and that
such Purchased  Shares must be held and not resold unless they are  subsequently
registered under the Act or an exemption from such registration is available and
the certificates issued to evidence such Purchased Shares shall contain a legend
to the foregoing effect.

     (b)  Purchaser  has had  access  to the  documents  referred  to in the
response  dated May 5,  2000 to the  Preliminary  Due  Diligence  Request  List,
including,  without  limitation,  the annual  report on Form 10-KSB for the year
ended  December 31, 1999,  the  quarterly  report on Form 10-QSB for the quarter
ended March 31,  2000,  filed by the Company  with the  Securities  and Exchange
Commission,  and has been furnished additional documents by the Company's patent
counsel.

     (c) Purchaser has had a reasonable  opportunity to ask questions of and
receive  answers  from the Company  concerning  the  Company  and the  Purchased
Shares, and any such questions have been answered  satisfactorily.  In addition,
Purchaser has had the  opportunity to request  additional  information  from the
Company. Any such requested additional information has been provided.

     (d)  Except  as set  forth in this  Agreement,  no  representations  or
warranties have been made to the Purchaser by the Company,  and in entering into
this  transaction,  the Purchaser is not relying upon any information other than
that referred to herein. Neither the Company, nor any other person acting on its
behalf has  offered or sold the  Purchased  Shares to  Purchaser  by any form of
general solicitation or general advertising.

     (e) Purchaser  understands  that the Purchased Shares are being offered
and sold in reliance on specific  exemptions from the registration  requirements
of federal and state  securities  laws and that the Company is relying  upon the
truth   and   accuracy   of   the   representations,   warranties,   agreements,
acknowledgments,  and  understandings of the Purchaser set forth herein in order
to  determine  the  applicability  of such  exemptions  and the  suitability  of
Purchaser to acquire the Purchased Shares.

                                       11

<PAGE>
     (f)  Purchaser  acknowledges  that the  certificate  for the  Purchased
Shares will bear the following  legend to the effect that the  Purchased  Shares
have been acquired for investment, have not been registered under the Securities
Act of 1933, and may not be sold,  transferred,  pledged, or hypothecated in the
absence of such  registration  or an  exemption  therefrom  under said Act,  and
appropriate  stop transfer  instructions  will be noted in the  Company's  stock
records.

                                   ARTICLE IV
                                   ----------

                                    COVENANTS
                                    ---------


                      [Pre-Closing Covenants Will Not Apply
         If the Agreement Is Executed Simultaneously With the Closing.]

     4.1  Pre-Closing  Covenants of the Company.  The Company  hereby  covenants
that,  from and  after  the  date  hereof  and  until  the  Closing  or  earlier
termination of this Agreement:

     (a) Access. Between the date hereof and Closing, the Company shall give
to authorized  representatives of the Purchaser (including,  without limitation,
attorneys,  accountants,   appraisers,   environmental  experts,  and  equipment
experts) (collectively, the "Representatives"),  access to and the right to make
complete  and  thorough  inspections  of the  Company and all its  business  and
assets,  Intellectual  Property,  and business  records,  during normal business
hours, in such manner as not to unduly disrupt normal business activities.

     (b)  Preservation of Business.  The Company shall preserve the preserve
the business of the Company.  Without  limiting the generality of the foregoing,
the Company shall take no action, or omit to take any action, that may adversely
affect the business and goodwill of the Company.  The Company  shall conduct its
business  only in the ordinary  and usual course and make no material  change in
any of its policies without the prior written consent of the Purchaser.  Between
the execution  date of the Agreement  and the Closing  Date,  the  stockholder's
equity of the  Company  shall not change  other than  through  normal  operating
profits or losses, and normal distributions  (including tax distributions),  all
of which  are paid in the  normal  and  ordinary  course  of  business,  without
Purchaser's prior written permission.

     (c)  Insurance.  The  Company  shall  maintain  in force the  insurance
policies  referenced  in Section  2.12,  except to the  extent  that they may be
replaced with equivalent policies.

     (d)  Liabilities.  The  Company  shall  not  incur  any  obligation  or
liability, absolute or contingent, except for those incurred in the ordinary and
usual course of its business; nor shall it pay any obligation or liability other
than: (a) debts,  liabilities,  and  obligations set forth in the Balance Sheet;
(b) debts,  liabilities and obligations  arising after the Balance Sheet Date in
the ordinary and usual course of its business;  and (c) debts,  liabilities  and
obligations  under the  contracts,  agreements,  past  practices,  arrangements,
relationships,  documents and instruments

                                       12

<PAGE>
listed,  described or contained in this Agreement or in the Exhibits attached to
this Agreement, or related to the performance of this Agreement by the Company.

     (e) No Breach. The Company will use its best efforts to assure that all of
the  representations  and warranties of the Company contained herein are true in
all  material  respects on the Closing  Date as if repeated at and as of such
time, and that no material  breach or default shall occur with respect to any of
its or their covenants,  representations or warranties contained herein that has
not been  cured by the  Closing.  The  Company  will not take any  action  or do
anything  that will  cause a breach of or  default  respecting  such  covenants,
representations  or  warranties,  and the  Company  shall  promptly  notify  the
Purchaser  of any event or fact  that  represents  or is likely to cause  such a
breach or default.

     (f) No  Agreements.  Neither  the  Company  nor any of its  officers or
directors  shall  enter into any  agreement  or  understanding,  for the sale or
possible sale of any  securities of the Company or the business or the assets of
the Company with anyone other than the Purchaser.

     (g) No Breach.  The Purchaser  will use its best efforts to assure that
all of its  representations  and  warranties  contained  herein  are true in all
material  respects as of the Closing Date as if repeated at and as of such time,
and that no material  breach or default  shall occur with  respect to any of its
covenants,  representations  or  warranties  contained  herein that has not been
cured by the Closing.  The Purchaser will not voluntarily  take any action or do
anything  which  will cause a breach of or default  respecting  such  covenants,
representations  and  warranties  and shall  promptly  notify the Company of any
event or fact which represents or is likely to cause such breach or default.


                                   ARTICLE V
                                   ---------

                           CONDITIONS PRECEDENT TO THE
                           ---------------------------
                      OBLIGATION OF THE PURCHASER TO CLOSE
                      ------------------------------------


     The  obligation of the Purchaser to enter into and complete the Closing
is subject to the  fulfillment,  prior to or on the Closing Date, of each of the
following  conditions,  any one or more of which may be waived by the  Purchaser
(except when the fulfillment of such condition is a requirement of law).

     5.1 Representations  and Warranties.  All representations and warranties of
the  Company  contained  in  this  Agreement  and  in  any  written   statement,
certificate,  or schedule  delivered  pursuant  hereto or in connection with the
transactions  contemplated  hereby  shall be true and  correct  in all  material
respects as at the Closing Date, as if made at the Closing and as of the Closing
Date.

     5.2  Covenants.  The  Company  shall have  performed  and  complied  in all
material  respects with all covenants and agreements  required by this Agreement
to be performed or complied with by each of them prior to or at the Closing.

                                       13

<PAGE>
     5.3 No Actions.  No action,  suit,  proceeding or investigation  shall have
been instituted, and be continuing before a court or before or by a governmental
body or agency, or shall have been threatened and be unresolved,  to restrain or
to  prevent  or to  obtain  damages  in  respect  of,  the  carrying  out of the
transactions  contemplated  hereby,  or which, if successful,  would  materially
affect  the right of the  Purchaser  to own the  Purchased  Stock or  which,  if
successful,  would  have a  material  adverse  effect  on the  operation  of the
Company's business.

     5.4  Consents;  Licenses and Permits.  The Company shall have each obtained
all  consents,  licenses,  and  permits  of  third  parties  necessary  for  the
performance  by it of its  obligations  under  this  Agreement  and  such  other
consents,  if any,  which are necessary to prevent (a) agreements of the Company
from  terminating,  the  termination of which,  in the  aggregate,  would have a
material adverse effect on the business,  financial condition,  or assets of the
Company,  or (b)  except for  indebtedness  for  borrowed  money,  any  material
indebtedness  of the Company from  becoming due or being subject to becoming due
with the  passage  of time or on notice as a result of the  performance  of this
Agreement;   any   other   provision   of  this   Agreement   to  the   contrary
notwithstanding.

     5.5 No Material Change.  There shall have been no material change,  whether
or not  adverse  at  the  Closing  Date  in the  business,  assets,  properties,
operations, financial status or prospects of the Company since the Balance Sheet
Date.

     5.6 Certificate. The Purchaser shall have received a certificate in the
form  annexed  hereto  as  Exhibit  5.6 dated the  Closing  Date,  signed by the
Chairman and Chief Executive Officer and Secretary or Assistant Secretary of the
Company as to the  satisfaction  of the  conditions  contained  in Sections  5.1
through 5.5.

     5.7 Opinion.  The Purchaser  shall have received the written opinion of
Brashear &  Associates,  P.L.,  dated the Closing  Date,  in form and  substance
reasonably  satisfactory to the Purchaser and its counsel  substantially  to the
effect set forth on Exhibit 5.7 hereto.

     5.8   Employment and Director's Agreement.






                                       14

<PAGE>

      (a) At the Closing. Weaver H. Gaines ("Gaines") shall have executed the
Employment  Agreement  with the Company  annexed  hereto as Exhibit 5.8 (a), and
such  Employment  Agreement  for Gaines  shall  supersede  in all  respects  the
Employment  Agreement for Gaines heretofore in effect dated August 31, 1994, and
all amendments, renewals, and modifications thereto.

      (b) At or Prior to the  Closing.  David C. Peck and the  Company  shall
terminate in all respects the Employment Agreement dated August 31, 1994 and the
Consulting  Agreement dated July 1, 1996, and all amendments,  modifications and
extensions  thereto,  (collectively  "Peck  Agreements")  and  pursuant  to such
termination,  David C. Peck shall  release the Company and the Purchaser and any
affiliate from all liability and obligations  whatsoever arising under said Peck
Agreements or the  termination  thereof and shall have  executed the  Director's
Agreement with the Company  annexed hereto as Exhibit 5.8(b) and such Director's
Agreement  shall  supersede  in all respects the  Employment  Agreement  and the
Consulting Agreement for Peck.

     5.9 Lease  Agreements.  At the Closing any landlord's  consents that may be
required under the Real Property leases with respect to the properties leased by
the Company to permit such leases to remain in effect on their current terms and
conditions following the Closing shall have been obtained by the Company.

     5.10 Deferred Compensation.

              (a) Prior to the  Closing,  the  Company  shall have  terminated
the following deferred  compensation  plans and all modification  amendments and
renewals  thereof:  (i) the Deferred  Compensation  Plan Agreement with David C.
Peck ("Peck") dated April 1, 1994; (ii) the Deferred Compensation Plan Agreement
with  Ammon  B.  Peck  dated  June 1,  1994  ("A.  Peck");  (iii)  the  Deferred
Compensation  Plan Agreement with Weaver H. Gaines  ("Gaines")  dated January 1,
1994, and the Deferred  Compensation  Plan Agreement with Theodore L. Snow dated
January 3, 1994 (collectively, the "Plans").

              (b) The  Company  shall have  obtained  releases  in favor of the
Company, the Purchaser and any affiliate from each of Peck, A. Peck, Gaines, and
Snow  releasing  the  Company,  the  Purchaser,   and  any  affiliate  from  all
obligations  and  liabilities   whatsoever  arising  under  said  Plans  or  the
termination thereof.

              (c) All deferred  compensation amounts arising pursuant to such
Plans shall have been  converted  into  restricted  shares of the Company Common
Stock at the rate of $4.00 per share;  provided  that  $84,000  of the  deferred
compensation amount owed to Peck shall not be so converted but instead,  will be
paid in cash to Peck by the Company at the closing.

     5.11  Additional  Documents.  The Company and the shall have  delivered all
such other  certificates  and documents as the Purchaser or its counsel may have
reasonably requested.


                                   ARTICLE VI
                                   ----------

                                       15

<PAGE>

                          CONDITIONS PRECEDENT TO THE
                          ---------------------------
                       OBLIGATION OF THE COMPANY TO CLOSE
                       ----------------------------------


     The obligation of the Company to enter into and complete the Closing is
subject to the  fulfillment,  prior to or on the  Closing  Date,  of each of the
following  conditions,  any one or more of which may be  waived  by the  Company
(except when the fulfillment of such condition is a requirement of law).

     6.1 Representations  and Warranties.  All representations and warranties of
the Purchaser contained in this Agreement and in any, Exhibit,  certificate,  or
schedule  delivered  pursuant  hereto  or in  connection  with the  transactions
contemplated hereby shall be true and correct in all material respects as at the
Closing Date, as if made at the Closing and as of the Closing Date.

     6.2  Covenants.  The  Purchaser  shall have  performed  and complied in all
material  respects with all covenants and agreements  required by this Agreement
to be performed or complied by it prior to or at the Closing.

     6.3 No Actions. No action,  suit,  proceeding,  or investigation shall have
been  instituted,  and  be  continuing,  before  a  court  or  before  or  by  a
governmental body or agency, or have been threatened,  and be unresolved, by any
governmental body or agency to restrain or prevent, or obtain damages in respect
of, the carrying  out of the  transactions  contemplated  hereby,  or which,  if
successful,  would have a material adverse effect on the assets,  properties and
business of the Purchaser.

     6.4 Consents. The Purchaser shall have obtained all consents,  licenses and
permits of third parties  necessary for the  performance  of all its  respective
obligations under this Agreement.

     6.5 Certificate.  The Company shall have received a certificate in the form
annexed  hereto as  Exhibit  6.5 dated the  Closing  Date,  signed by  Per-Olof.
Wallstrom,  the authorized  representative of Purchaser's sole Member, Q-Med, AB
(publ),  a  corporation  organized  under  the  laws of the  Kingdom  of  Sweden
("Q-Med") as to the  satisfaction  of the  conditions  contained in Sections 6.1
through 6.5.

     6.6 Side Letter.  Purchaser  shall have  delivered a side letter  agreement
setting forth certain  agreements of Q-Med in the form annexed hereto as Exhibit
6.6, dated the Closing Date, signed by authorized representatives of Q-Med.

     6.7  Additional  Documents.  The  Purchaser  shall have  delivered all such
certified resolutions,  certificates and documents with respect to the Purchaser
as the Company or their counsel reasonably may have requested.

                                       16

<PAGE>
                                  ARTICLE VII
                                  -----------

                                    CLOSING
                                    -------

     7.1 The  Closing.  The  closing  of the  purchase  of the  Purchased  Stock
contemplated  by this  Agreement  (the  "Closing")  shall  be  deemed  to  occur
simultaneously  with the satisfaction of all of the conditions  precedent to the
obligations  of the  parties to close as set forth in Articles V and VI and upon
the delivery by the parties of all of the items to be delivered by them pursuant
to Sections 7.4 and 7.5 of this Article VII. The date on which the Closing shall
be deemed to have  occurred  is referred to in this  Agreement  as the  "Closing
Date."

     7.2 Location,  Time and Date. The location for the delivery of the items to
be delivered by the parties under the conditions of Closing set forth in Section
7.3 hereof shall be at the New York Athletic Club,  180 Central Park South,  New
York,  NY 10019 at 2:00 p.m., or at such other time and place as may be actually
agreed to by the parties hereto, but in any event not later than July 14, 2000.

     7.3 Conditions of Closing. The delivery of the items to be delivered by the
Company as provided  in Section  7.4 hereof and the  delivery of the items to be
delivered by the  Purchaser  as provided in Section 7.5 hereof shall  constitute
the conditions of Closing.

     7.4 Items to be Delivered by the Company. At the Closing,  the Company will
deliver or cause to be delivered to the Purchaser:

              (a)    The  certificates  for the  Purchased  Stock which,  when
combined with the shares of the Company Common Stock previously  issued to Q-Med
prior to the Closing will represent  approximately  fifty-nine  percent (59%) of
the Issued Common Stock;

              (b)    The certificate required by Section 5.6;

              (c)    The opinion of Brashear & Associates, P.L., as required
                     by Section 5.7;

              (d)    The  Employment  Agreement  required by Section 5.8(a);

              (e)    The Director's Agreement required by Section 5.8 (b);

              (f)    The Shareholders' Agreement;

              (g)    The Landlord's Consents required by Section 5.10;

              (h)    Resignation of Karl-E Arfors as a director of the Company;

              (i)    Such  other   certified   resolutions,   documents,   and
          certificates  as are required to be delivered by the Company  pursuant
          to the  provisions  of this  Agreement.

                                       17

 <PAGE>

     7.5 Items to be Delivered by Purchaser.  At the Closing, the Purchaser will
deliver or cause to be delivered to the Company:

              (a)    One half of the Purchase Price in the amount of $3,321 697;

              (b)    The certificate required by Section 6.5;

              (c) Such other certified resolutions, documents and certificates
as are required to be delivered by the Purchaser  pursuant to the  provisions of
this Agreement.

     7.6 Transfer of Possession.  As of the Closing,  the Company shall give the
Purchaser full possession and enjoyment of the Purchased Stock.



                                  ARTICLE VIII
                                  ------------

                  SURVIVAL OF REPRESENTATIONS; INDEMNIFICATION
                  --------------------------------------------


     8.1   Survival.   The   parties   hereto   agree  that   their   respective
representations,   warranties,  covenants,  and  agreements  contained  in  this
Agreement shall survive the Closing for a period (the "Indemnification Period"),
as follows:

              (a) with respect to claims for indemnification  hereunder
regarding  taxes  or  tax  liabilities  (including  any  penalties  or  interest
applicable thereto),  for a period equal to the fullest extent of any applicable
statutes of limitations  governing such tax liabilities,  including  waivers and
extensions with respect to all tax liabilities, plus sixty (60) days; and

              (b) with respect to claims for indemnification  hereunder
regarding liabilities other than tax liabilities,  for a period of two (2) years
following the Closing Date.

To the extent that an  Indemnified  Party (as  hereinafter  defined)  asserts in
writing a claim for Damages (as  hereinafter  defined)  against an  Indemnifying
Party (as  hereinafter  defined) prior to the expiration of the  Indemnification
Period,  which  claim  reasonably  identifies  the basis for the  claims and the
amounts of any reasonably  ascertainable  damages,  the  Indemnification  Period
shall be extended  for such claim until such claim is  resolved,  subject to the
limitations hereinafter provided.

     8.2 Indemnification by the Company.  The Company agrees to save, defend and
indemnify the Purchaser and any affiliate, their officers, directors, employees,
and agents against and hold them harmless from any and all liabilities, of every
kind,  nature  and  description,   fixed  or  contingent   (including,   without
limitation,  reasonable counsel fees and expenses in connection with any action,
claim or proceeding  relating to such liabilities)  ("Damages") arising from the
breach of the Company's  representations,  warranties,  covenants, or agreements
contained  herein or in the several Exhibits  hereto,  and the  representations,
warranties,  covenants or agreements of

                                       18

<PAGE>
the  Company  contained  herein,  or the  documents  executed  by the Company in
connection  herewith,  which arise during and the basis for which is made during
the Indemnification Period, including,  without limitation,  any tax liabilities
to the extent not so reflected or reserved against in the Balance Sheet.

     8.3 Indemnification by the Purchaser. The Purchaser agrees to save, defend,
and  indemnify  the Company,  its  officers,  directors,  employees,  and agents
against and hold it harmless from any and all Damages arising from the breach of
any of the Purchaser's  representations,  warranties,  covenants,  or agreements
contained herein or the documents executed by Purchaser in connection  herewith,
which arise during the Indemnification Period.

     8.4 Limitations of Liability.

    (a)  Claims.  All  claims  for  Damages  arising  out  of  breaches  of
representations or warranties  regarding tax deficiency  assessments relating to
federal and state income tax returns  filed prior to closing,  shall be computed
net of the  present  value of all  readily  ascertainable  future  tax  benefits
associated  therewith.  No claim shall be made for matters adequately covered by
insurance.  The parties waive subrogation rights against each other with respect
to all  matters  as to which an  insurance  recovery  shall  have been  actually
received after the Closing so long as the terms of any insurance  policy are not
violated by such waiver.

    (b) Liability of the Company.  Upon a final  determination (as provided in
Section 8(d)) of the amount of any claim for Damages made against the Company by
the Purchaser and /or any  affiliate,  the  Purchaser  and/or such  affiliate
shall be entitled to recover the amount of such  Damages as finally  determined.
Notwithstanding the foregoing:

    (i) The Company  shall not be required to indemnify  the  Purchaser and
        /or any affiliate  for any claim unless and until the aggregate  amount
        of such Damages otherwise payable by the Company hereunder individually
        or in the  aggregate  shall  equal or  exceed  Fifty  Thousand  Dollars
        ($50,000).  Once the aggregate  amount of all such Damages shall exceed
        Fifty Thousand  Dollars  ($50,000),  the Purchaser and/or any affiliate
        shall be entitled to recover from the Company the entire  amount of the
        excess Damages (including such $50,000).

    (ii) The  aggregate  liability of the Company for  indemnity  hereunder
         shall never exceed the Purchase Price.

    (c) Liability of the Purchaser.  Subject to the  immediately  following
paragraph,  upon a Final  Determination  (as  provided  in Section  8(d)) of the
amount of any claim for Damages made against the  Purchaser or any  affiliate by
the Company, the Company shall be entitled to recover the amount of such Damages
as finally  determined,  provided  that such Damages shall not exceed so much of
the Purchase Price as shall have been paid.

    The  Purchaser  shall not be required to indemnify  the Company and /or any
affiliate  for any claim  unless  and until  the  aggregate  amount of such
damages  otherwise  payable by the Purchaser  hereunder  individually  or in the
aggregate  shall equal or exceed  Fifty  Thousand

                                       19

<PAGE>
Dollars  ($50,000).  Once the aggregate  amount of all such Damages shall exceed
Fifty Thousand Dollars ($50,000),  the Company shall be entitled to recover from
the Purchaser the entire amount of the excess Damages (including such $50,000).

        (d) Final  Determination.  For the  purposes  of  Section  8.4, a Final
Determination shall exist when (i) the parties agree upon the amount, or (ii) an
arbitrator shall have made a Final Determination with respect thereto and appeal
therefrom  shall not have been taken  within  thirty  (30) days from the date of
such  determination,  or such  greater or lesser time as any court of  competent
jurisdiction  shall require.  The asserting party will assign to the other party
any claims against which the asserting  party has been  indemnified and has been
paid as provided herein, as to which there may be claims against others, and the
other party in all respects  shall be  subrogated to the rights of the asserting
party in connection therewith.

     8.5 Defense of Claims.  Each party entitled to  indemnification  under this
Article VIII (the  "Indemnified  Party")  agrees to notify the party required to
provide indemnification (the "Indemnifying Party") with reasonable promptness of
any claim asserted against it in respect of which the Indemnifying  Party may be
liable  under this  Agreement,  which  notification  shall be  accompanied  by a
written  statement  setting  forth  the basis of such  claim  and the  manner of
calculation  thereof.  The failure of the  Indemnified  Party to  promptly  give
notice shall not preclude such Indemnified Party from obtaining  indemnification
under this  Article 8,  except to the extent,  and only to the extent,  that the
Indemnifying  Party's  failure  actually  prejudices the rights or increases the
liabilities and obligations of the Indemnifying  Party.  The Indemnifying  Party
shall have the right, at its election, to defend or compromise any such claim at
their own expense with counsel of their choice; provided, however, that (a) such
counsel shall have been approved by the  Indemnified  Party prior to engagement,
which  approval  shall  not  be  unreasonably   withheld  or  delayed;  (b)  the
Indemnified Party may participate in such defense, if it so chooses with its own
counsel and at its own expense;  and (c) any such defense or compromise shall be
conducted in a manner which is  reasonable  and not contrary to the  Indemnified
Party's  interest.  In the event the  Indemnifying  Party does not  undertake to
defend  or  compromise,   the  Indemnifying  Party  shall  promptly  notify  the
Indemnified  Party of its intention not to undertake to defend or compromise the
claim.


                                   ARTICLE IX
                                   ----------

                             TERMINATION AND WAIVER
                             ----------------------

     9.1 Termination.  Anything herein or elsewhere to the contrary
notwithstanding,  this Agreement may be terminated and the transactions provided
for herein abandoned at any time prior to the Closing:

               (a)  By mutual consent of the Purchaser and the Company;

                                       20

<PAGE>
               (b) By the  Purchaser  if any of the  conditions  set forth in
Article V hereof shall not have been  fulfilled on or prior to September 1, 2000
(subject to extension by agreement),  or shall become  incapable of fulfillment,
and shall not have been waived;

               (c) By the Company if any of the conditions set forth in Article
VI  hereof  shall  not have  been  fulfilled  on or prior to  September  1, 2000
(subject  to  extension  by  agreement),  or  shall  have  become  incapable  of
fulfillment, and shall not have been waived; or

               (d) By the  Purchaser  or the Company,  if any legal  action or
proceeding  shall  have been  instituted  or  threatened  seeking  to  restrain,
prohibit,  invalidate,  or otherwise affect the consummation of the transactions
contemplated by this Agreement  which makes it  inadvisable,  in the judgment of
the Purchaser or the Company, to consummate same.

        In the event that this Agreement is terminated as described above, this
Agreement  shall be void and of no force and effect,  without any  liability  or
obligation  on the part of any of the parties  hereto  except for any  liability
which may arise pursuant to Section 10.1, 10.2, and 10.4.

     9.2  Waivers.  Any  condition  to the  performance  of the  Company  or the
Purchaser  that  legally  may be waived on or prior to the  Closing  Date may be
waived at any time by the party entitled to the benefit  thereof by action taken
or  authorized by an  instrument  in writing  executed by the relevant  party or
parties. The failure of any party at any time or times to require performance of
any  provision  hereof  shall in no manner  affect  the right of such party at a
later  time to  enforce  the same.  No waiver by any party of the  breach of any
term,  covenant,  representation,  or warranty  contained in this Agreement as a
condition  to such party's  obligations  hereunder  shall  release or affect any
liability  resulting from such breach,  and no waiver of any nature,  whether by
conduct or  otherwise,  in any one or more  instances,  shall be deemed to be or
construed  as a further or  continuing  waiver of any such  condition  or of any
breach  of  any  other  term,  covenant,  representation  or  warranty  of  this
Agreement.


                                   ARTICLE X
                                   ---------

                            MISCELLANEOUS PROVISIONS
                            ------------------------


     10.1 Expenses.  Except as otherwise  expressly provided or set forth in, or
required by, this  Agreement,  the  Purchaser  and any affiliate and the Company
shall each bear their own expenses in connection herewith.

     10.2  Confidential  Information.  Each party agrees that such party and its
representatives  will hold in strict  confidence and not divulge or disclose any
information  and  documents   received  from  the  other  parties  and,  if  the
transactions  herein  contemplated  shall not be  consummated,  each  party will
continue to hold such  information  and documents in strict  confidence and will
return to such other parties all such documents (including the exhibits attached
to this Agreement) then in such receiving party's  possession  without retaining
copies thereof;  provided,  however,  that each party's  obligations  under this
Section 10.2 to maintain such
                                       21

<PAGE>
confidentiality  shall not apply to any information or documents that are in the
public  domain at the time  furnished  by the  others or that come in the public
domain  thereafter  through  any  means  other  than as a  result  of any act or
omission  of the  receiving  party  or of its  agents,  officers,  directors  or
stockholders which constitutes a breach of this Agreement,  or that are required
by applicable law to be disclosed. In the event of a breach or threatened breach
under this Section  10.2,  the parties to this  Agreement  acknowledge  that the
person or persons  harmed or  threatened  to be harmed  thereby will not have an
adequate  remedy at law, and shall be entitled to such  equitable and injunctive
relief as may be  available to restrain  the  violation  of this  Section  10.2;
provided,  however,  that nothing herein shall be construed as prohibiting  such
persons from pursuing any other remedies available for such breach or threatened
breach, including the recovery of damages.

     10.3  Modification,  Termination or Waiver.  This Agreement may be amended,
modified,   superseded  or  terminated,   and  any  of  the  terms,   covenants,
representations,  warranties or conditions  hereof may be waived,  but only by a
written instrument executed by the party waiving compliance.  The failure of any
party at any time or times to require  performance of any provision hereof shall
in no manner affect the right of such party at a later time to enforce the same.

     10.4  Publicity.  The  parties  agree that no  publicity,  release or other
public announcement  concerning the transactions  contemplated by this Agreement
shall be issued by either  party  without the advance  approval of both the form
and substance of the same by the other party and its counsel, which approval, in
the case of any  publicity,  release or other  public  announcement  required by
applicable law, shall not be unreasonably withheld or delayed.

     10.5 Notices.  Any notice or other  communication  required or which may be
given hereunder shall be in writing and either be delivered (a) personally,  (b)
be mailed,  certified or registered mail, postage prepaid, (c) sent by overnight
courier delivery service, receipt acknowledged, fees prepaid, or (d) transmitted
by facsimile  transmission to a telephone  number as to which one party notifies
the other.  Notice  shall be deemed given when so  delivered  personally,  or if
mailed or sent by  courier  service,  five (5) days after the date of mailing or
deposited with the courier service, addressed as follows:

If to the Purchaser, to:                  QVESTOR LLC
                                              C/O
                                              The Corporation Trust Company
                                              1209 Orange Street
                                              Wilmington, Delaware 19801

With a copy to:                               Terence F. Brennan
                                              Holland & Knight LLP
                                              200 South Orange Avenue
                                              Suite 2600
                                              Orlando, Florida 32801
                                              Fax: 407- 244-5288


                                       22

<PAGE>

If to the Company:                     Ixion Biotechnology, Inc.
                                       13704 Progress Boulevard, Box 13
                                       Alachua, Florida 32615
                                       Fax: 904-418-1583
                                       Attn: Weaver H. Gaines
                                             Chairman & Chief Executive Officer

With a copy to:                        Bruce Brashear, Esq.
                                       Brashear & Associates, P.L.
                                       926 NW 13th Street,
                                       Gainesville, FL 32601
                                       Fax: 352-336-0505


If notice is provided by facsimile it shall be deemed given upon confirmation of
transmission.  The parties may change the  persons  and  addresses  to which the
notices or other  communications  are to be sent by giving written notice of any
such change in the manner provided herein for giving notice.

     10.6 Binding Effect and  Assignment.  This Agreement  shall be binding upon
and inure to the benefit of the  successors  and assigns of the parties  hereto;
provided,  however,  that no  assignment  of any  rights  or  delegation  of any
obligations  provided  for herein may be made by any party  without  the express
written consent of the other parties.

     10.7 Entire Agreement.  This Agreement  represents the entire understanding
and agreement between the parties with respect to the subject matter hereof, and
supersedes all of the negotiations, understandings, and representations (if any)
made by and between such parties.

     10.8 Exhibits.  All exhibits or schedules  annexed hereto (the  "Exhibits")
are expressly  made a part of this  Agreement as fully as though  completely set
forth  herein,  and all  references to this  Agreement  herein or in any of such
Exhibits shall be deemed to refer to and include all such Exhibits.

     10.9 Governing Law; CPR; Arbitration. This Agreement shall be construed and
enforced in accordance  with the local laws of the State of Delaware  applicable
to  agreements  to be executed and  performed  wholly  within said state without
giving effect to its conflicts of laws provisions.

     The parties agree that in the case of any dispute  between  them, they will
attempt in good faith to resolve any controversy or claim arising out of or
relating to this Agreement by mediation in accordance with the Center for Public
Resources Model Procedure for Mediation of Business Disputes.

                                       23

<PAGE>

       If the matter has not been resolved pursuant to the aforesaid mediation
procedure  within sixty days of the commencement of such procedure (which period
may be  extend  by  mutual  agreement),  the  controversy  shall be  settled  by
arbitration  in  accordance  with the  Center  for  Public  Resources  Rules for
Non-Administered Arbitration of Business Disputes, by three arbitrators, of whom
each party shall  appoint one. The  arbitration  shall be governed by the United
States  Arbitration Act, 9 U.S.C. ss. 1-16, and judgment upon the award rendered
by the  Arbitrator(s) may be entered by any court having  jurisdiction  thereof.
The place of arbitration shall be Orlando , Florida.

     10.10 Section  Headings.  The section headings  contained in this Agreement
are inserted for  convenience of reference only and shall not affect the meaning
or interpretation of this Agreement.

     10.11 Gender.  Words of the  masculine  gender in this  Agreement  shall be
deemed and  construed  to include  correlative  words of the feminine and neuter
genders and words of the neuter  gender shall be deemed and construed to include
correlative words of the masculine and feminine genders.

     10.12  Severability.  The  invalidity  or  unenforceability  of any term or
provision  of this  Agreement  shall in no way  impair  or  affect  the  balance
thereof, which shall remain in full force and effect.

     10.13  Attorneys'  Fees. In the event any  arbitration  arises out of or in
connection with this Agreement between the parties hereto,  the prevailing party
in such arbitration shall be entitled to recover from the other party or parties
all  reasonable  attorneys'  fees,  expenses,  and suit costs,  including  those
associated with any appellate or post-judgment collection proceeding.

     10.14 Counterparts. This Agreement may be executed in counterparts, each of
which shall be deemed to be an original, but which together shall constitute one
and the same instrument.

     10.15  Recitals.  The recitals set forth at the beginning of this Agreement
are  true  and  correct  and  incorporated  by  reference  into the body of this
Agreement.

     10.16  Definition of  Knowledge.  Whenever a statement of any party to this
Agreement is qualified by that party's "knowledge", "knowledge" means the actual
knowledge  of the person  making such  statement  at the time or times that such
statement  is  made.  If the  statement  is made by a  corporation,  the  actual
knowledge of the corporation's  officers,  directors and employees is imputed to
the  corporation;  otherwise,  the  actual  knowledge  of a person  shall not be
imputed to any other person.

     10.17 Benefits to Others. Except with respect to any affiliate of Purchaser
as set forth in various sections  herein,  the  representations,  warranties and
covenants  contained in this  Agreement  are for the sole benefit of the parties
hereto and their successors and permitted assigns, and they shall not confer and
are not intended to confer any rights on any other persons.

                                       24

<PAGE>

     END OF TEXT, SIGNATURE PAGES FOLLOW

                                       25

<PAGE>


         IN WITNESS WHEREOF,  the parties have executed this Agreement as of the
date first above written.



                                       "PURCHASER"

                                       QVESTOR LLC



                                                        /S/
                                       By:__________________________________
                                       Per-Olof Wallstrom
                                       Authorized Representative of
                                       Purchaser's Sole Member


                                       26

<PAGE>


        IN WITNESS WHEREOF,  the parties have executed this Agreement as of the
date first above written.


                                       "COMPANY"

                                       IXION BIOTECHNOLOGY, INC.




                                                        /S/
                                       By:________________________________
                                         Weaver  H.  Gaines
                                         Chairman & Chief Executive Officer



                                       27

<PAGE>

                                List of Schedules
                                -----------------

         Schedule               Description
         --------               -----------


         Schedule 2.1           Qualification
         Schedule 2.2           List of subscriptions, options, etc.
         Schedule 2.3           Subsidiaries
         Schedule 2.4           Consents
         Schedule 2.6           Financial Statements
         Schedule 2.7           Liabilities
         Schedule 2.8           Actions Since Balance Sheet Date
         Schedule 2.9           Absence of Material Changes
         Schedule 2.10          Taxes
         Schedule 2.11          Ownership of Assets; Trademarks; etc.
         Schedule 2.12          Insurance
         Schedule 2.13          Litigation, Compliance with Laws
         Schedule 2.14          Real Property
         Schedule 2.15          Agreements and Obligations, Performance
         Schedule 2.16          Condition of Assets
         Schedule 2.17          Accounts and Notes Receivable
         Schedule 2.18          Permits and Licenses
         Schedule 2.19          Banking Arrangements
         Schedule 2.20          Interest in Assets
         Schedule 2.21          Salary Information
         Schedule 2.22          Employee Benefit Plans
         Schedule 2.23          Brokers
         Schedule 2.24          Labor Discussions
         Schedule 2.25          Change of Name
         Schedule 3.1           Consents

                                       28

<PAGE>



                                List of Exhibits
                                ----------------

         Exhibit                  Description
         -------                  -----------

         Exhibit 1.1              Shareholders' Agreement
         Exhibit 5.6              Certificate of Company
         Exhibit 5.7              Opinion of Brashear & Associates, P.L.
         Exhibit 5.8(a)           Employment Agreement of Weaver H. Gaines
         Exhibit 5.8(b)           Director's  Agreement of David C. Peck
         Exhibit 6.5              Certificate of Purchaser
         Exhibit 6.6              Side Letter (Q-Med)

                                       29


<PAGE>


                                  SCHEDULE 2.1
                                  ------------

            Jurisdictions where Company is authorized to do Business



Jurisdictions where Company is authorized to do Business:
---------------------------------------------------------

     o        Delaware
     o        Florida



<PAGE>


                            SCHEDULE 2.1 (continued)
                            ------------------------

Certificate(s) of Good Standing,  Certificate of Incorporation and Bylaws of the
                                    Company




Certificate of Incorporation  and Amendments  thereto certified by the Secretary
--------------------------------------------------------------------------------
of State of Delaware:
---------------------

                                  See attached



Bylaws certified by the Secretary of the Company:
-------------------------------------------------

                                  See attached.


<PAGE>


                                  SCHEDULE 2.2
                                  ------------

List of Subscriptions, Options, Warrants, Rights, Calls or other Commitments and
                  Agreements concerning Company's Common Stock


Options, warrants, rights, or calls:
------------------------------------

     o    Qualified  and  nonqualified  options to  purchase  268,400  shares of
          Company  Common  Stock under the 1994 Stock  Option Plan
     o    Warrants  to  purchase  17,630  shares of Company  Common  Stock at an
          exercise  price  of $2  per  share,  expiring  August  31,  2000
     o    The University of Florida Research Foundation,  Inc., holder of 15,630
          of the 17,630 warrants  referred to above,  has asserted a claim to an
          additional  3,042  warrants to purchase  shares at $2 per share,  also
          expiring August 31, 2000,  pursuant to the Incubator License Agreement
          dated June 26, 1995, as amended.  The Company  disputes this claim and
          the matter is under discussion.
     o    Warrant  to  purchase  6,000  shares  of  Company  Common  Stock at an
          exercise price of $5 per share, expiring as to 3,000 warrants February
          2002  and as to the  balance,  expiring  October  2002.
     o    Charitable  Benefit  Warrants  to  purchase  21, 523 shares of Company
          Common Stock at an exercise price of $8 per share,  expiring  December
          9, 2007.

Convertible securities:
-----------------------

     o    $787,270 in convertible  unsecured notes due 2001,  convertible into a
          maximum of 323,557 shares of Company Common Stock
     o    Convertible  promissory  note with Weaver H.  Gaines,  dated March 31,
          1993  (outstanding   principal  convertible  to  stock;  there  is  no
          outstanding principal under this note at the date of this schedule.)
     o    Convertible  promissory  note with David C. Peck,  dated  October  15,
          1993(outstanding   principal   convertible  to  stock;   there  is  no
          outstanding principal under this note at the date of this schedule.)



<PAGE>



                                  SCHEDULE 2.3
                                  ------------

                             Company's Subsidiaries



                                     None.



<PAGE>



                                  SCHEDULE 2.4
                                  ------------

                          Consents required for Company




                                      None.



<PAGE>

                                  SCHEDULE 2.6
                                  ------------

                              Financial Statements



See the following attached documents:

     o    Audited Financial Statements for the year ended 1997

     o    Audited Financial Statements for the year ended 1998

     o    Audited Financial Statements for the year ended 1999

     o    Interim,  Unaudited Statements of Operations for five months ended
          May 31, 2000

     o    Interim, Unaudited Balance Sheet as at May 31, 2000



<PAGE>


                                  SCHEDULE 2.7
                                  ------------

                    Other Debts, Obligations and Liabilities



On June 23,  2000,  the  Company  borrowed  $48,000  through  the  issuance of a
commercial  fixed rate  promissory  note due December 23, 2000 to SunTrust Bank.
The  terms of the note  require  five  monthly  interest  payments  at an annual
interest  rate of 7.83%,  and a balloon  payment of  principal  and last month's
interest on the maturity  date.  There is no  pre-payment  penalty.  The note is
secured by a certificate of deposit of even amount purchased from SunTrust Bank,
bearing  interest  at the  annual  rate of 5.83%.  This note was  issued for the
purchase of an AKTAexplorer liquid chromatography system from Amersham Pharmacia
Biotech, Inc., for a purchase price of $48,850.




<PAGE>

                                  SCHEDULE 2.8
                                  ------------

                Actions taken by Company since Balance Sheet Date



     o    During June,  2000, the Company issued 37,500 shares of Company Common
          Stock to  purchasers  of  shares  in the  Company's  registered  stock
          offering and 600 shares to an employee  pursuant to its Board Retainer
          Plan. These shares are included in the  reconciliation  of outstanding
          shares as of June 30, 2000 on a fully-diluted basis.

     o    On June 23, 2000, the Company borrowed $48,000 through the issuance of
          a  commercial  fixed rate  promissory  note due  December  23, 2000 to
          SunTrust  Bank.  The terms of the note require  five monthly  interest
          payments at an annual interest rate of 7.83%, and a balloon payment of
          principal and last month's  interest on the maturity date. There is no
          pre-payment  penalty.  The  note is  secured  by the  assignment  of a
          certificate of deposit of even amount  purchased from SunTrust Bank on
          June 23,  2000,  bearing  interest at the annual  rate of 5.83%.  This
          promissory note was issued for the purchase of an AKTAexplorer  liquid
          chromatography  system from Amersham  Pharmacia  Biotech,  Inc., for a
          purchase price of $48,850.

     o    The Company has orally  agreed,  subject to board  approval,  to lease
          2,661  square feet of  increased  laboratory  and office  space and to
          exercise  its  option to extend  the lease term by one year to October
          31, 2002,  under the Lease  Agreement  dated as of September 18, 1998,
          between the Company  and  Innovations  Partners,  Ltd.  (successor  in
          interest to Echelon International Corporation). In addition, the Lease
          Agreement  will be amended to convert the  calculation  of rent from a
          base rent  plus  operating  stop to a gross  rent.  The  effect of the
          proposed  amendments  to the Lease  Agreement  will be to increase the
          annual rent during 2000 from $80,230 per year to $112,682 per year.



<PAGE>
                                  SCHEDULE 2.9
                                  ------------

                           Material Changes to Company



See description of purchase of AKTAexplorer  described in attached Schedules 2.7
and 2.8 to this Agreement.




<PAGE>


                                  SCHEDULE 2.10
                                  -------------

                             Unpaid Taxes of Company




                                      None.



<PAGE>

                                  SCHEDULE 2.11
                                  -------------

Assets, Properties and Intellectual Property in which Company does not have Good
                              and Marketable Title




                                     None.


<PAGE>

                             SCHEDULE 2.11 continued
                             -----------------------
                           (dated as of July 12, 2000)

List of Persons or Entities  which have an Interest  in  Company's  Intellectual
                                  Property and
           List of Agreements Requiring Payment of Royalties re: such
                             Intellectual Property


Persons or Entities which have an Interest in Company's Intellectual Property:
------------------------------------------------------------------------------

See  attached  Schedules  2.7 and  2.8 to  this  Agreement  for  description  of
assignment  of CD for $48,000 to secure loan from  SunTrust Bank for purchase of
equipment.

Licensed Patents and Patent Applications:
-----------------------------------------

     (a)      Islet Patents (UF-141 Cases-Accounts 18302 et. seq.

              (i)      United States Patents and Patent Applications:

                              o    US 5,834,308  (UF-141,  Peck1),  "In Vitro
                                   Growth of  Functional  Islets of Langerhans,"
                                   was issued on November 10, 1998.  Licensed
                                   from University of Florida Research
                                   Foundation, Inc. (UFRFI).

                              o    US 6,001,647 (UF-141.C2, Peck), "In Vitro
                                   Growth of Functional Islets of Langerhans and
                                   In Vivo Uses Thereof," was issued on
                                   December 14, 1999. Licensed from UFRFI

                              o    US Application  No.09/406,253 (UF-141.C3,
                                   Peck and  Ramiya),  "Reversal  of Insulin
                                   Dependent  Diabetes  by  IPSC,  IPCs  and
                                   Islet-like    Structures,"    filed    27
                                   September  1999.   Licensed  from  UFRFI;
                                   Ramiya rights assigned to the Company.

              (ii) Foreign Patents and Patent Applications:

                              o    Australian Letters Patent No. 709165
                                   (UF 141.C1/PCT-AU), "In vitro growth of
                                   functional islets of Langerhans and in vivo
                                   uses thereof," issued 9 December 1999.
                                   Licensed from UFRFI.

                              o    The  Company  also  has  foreign   patent
                                   applications,   not  separately   listed,
                                   filed  in  Australia,   Canada,   Europe,
                                   Japan,  Korea,  and  Mexico  where  it is
                                   seeking  protection  of similar  scope to
                                   that  claimed in the above U.S.  patents.
                                   These foreign licenses are licensed under
                                   the same license  agreement  covering the
                                   U.S. patents and patent application.



<PAGE>

     (b)      Oxalate Patents (UF- 145 Series-Accounts 18301 et. seq.)

             (i)      United States Patents and Patent Applications:
                              o   U.S. Patent No. 5,604,111 (UF-145, Peck),
                                  "Method and Kit for Detection of Oxalate in a
                                  Fluid Sample," issued on 18 February 1997.
                                  Licensed from UFRFI.

                              o   U.S. Patent No. 5,837,833 (UF-145.C1, Peck),
                                  "Materials  and  Methods for  Detection  of
                                  Oxalate"  issued 17 November  1998.  Licensed
                                  from UFRFI.

                              o   U.S. Patent No. 5,912,125 (UF-145.C2, Peck),
                                  "Materials and Methods for Detecting
                                  Oxalobacter formigenes," issued on
                                  15 June 1999. Licensed from UFRFI.

                              o   U.S.     Application    No.    08/888,610
                                  (UF-145.C3,  Peck and Sidhu),  "Materials and
                                  Methods    for     Detection    of
                                  Oxalobacter," filed 26 June 1997, renamed
                                  "Process for  Preparation  of Recombinant
                                  Formyl-CoA   Transferase  of  Oxalobacter
                                  Formigenes."  Licensed from UFRFI;  Sidhu
                                  rights assigned to the Company.

                              o   U.S. Application No. 08/936,094 (UF-145.C4,
                                  Peck and Sidhu), "Materials and Methods for
                                  Detection of Oxalobacter," filed 23 September
                                  1997.  Licensed from UFRFI; Sidhu rights
                                  assigned to the Company.

                              o   U.S. Application No. 08/841,174 (UF-145DF,
                                  Peck), "Materials and Methods for Detection of
                                  Oxalate," filed 29 April 1997.  Licensed from
                                  UFRFI.


             (ii)     Foreign Patents and Patent Applications:

                              o   Australian Letters Patent No. 710,652
                                  (UF-145.C1/PCT-AU, Peck), "Materials and
                                  Methods for Detection  of Oxalate," filed 6
                                  Jun 1995, issued on  20 Jun 2000. Licensed
                                  from UFRFI.

                              o   The  Company  also  has  foreign   patent
                                  applications,   not  separately   listed,
                                  filed  in  Australia,   Canada,   Europe,
                                  India,  Japan, Korea, and Mexico where it
                                  is seeking protection of similar scope to
                                  that  claimed in the above U.S.  patents.
                                  These



<PAGE>

                                  foreign licenses are licensed under the same
                                  license  agreement  covering the U.S. patents
                                  and patent application.

     (c)   Oxalate Patents (IXN-100 Series-Accounts 18304 et seq.)

                             o    U.S. Application No. 09/083,362 (IXN-100,
                                  Allison   and  Sidhu),   "Materials   and
                                  Methods  for   Treating   or   Preventing
                                  Oxalate  Related  Disease," filed May 22, 1998
                                  (claiming  priority from provisional
                                  application U.S. 60/047,473, filed 23 May
                                  1997),  was  allowed  on 14 June 14 2000.
                                  Licensed  from  Milton  J.  Allison  (see
                                  Schedule 2.20);  Sidhu rights assigned to the
                                  Company.

                             o    U.S.     Application    No.    09/500,500
                                  (IXN-100C1XC1,    Allison   and   Sidhu),
                                  "Materials  and Methods  for  Treating or
                                  Preventing   Oxalate   Related   Disease"
                                  (claiming   priority   from   provisional
                                  applications  US  60/150,259,   filed  23
                                  August 1999 and US  60/047,473,  filed 23
                                  May  1997),   filed  9   February   2000.
                                  Licensed  from  Milton  J.  Allison  (see
                                  Schedule 2.20);  Sidhu rights assigned to
                                  Ixion.

                             o    The  Company  also  has  foreign   patent
                                  applications,   not  separately   listed,
                                  filed  in  Australia,   Canada,   Europe,
                                  India,  Japan, Korea, and Mexico where it is
                                  seeking protection of similar scope to that
                                  claimed in the above U.S.  patents. These
                                  foreign licenses are licensed under the same
                                  license  agreement  covering the U.S. patents
                                  and patent application.

                             o    US 5,187,071 (Fischer and Jensen), "Method for
                                  the Selective Control of Weeds, Pests, and
                                  Microbes," was issued on 16 February 1993.
                                  Licensed from Fischer and Jensen.

                             o    All of the above patents are licensed
                                  pursuant to license agreements requiring the
                                  payment of royalties to the owners of the
                                  patent rights.  In addition, the Company has a
                                  license agreement with Brookhaven National
                                  Laboratory requiring the payment of royalties
                                  for the use of T7 technology used in
                                  recombinant oxalate degrading enzyme, as well
                                  as a license agreement with UFRFI relating to
                                  its former lease at the Biotechnology
                                  Development Institute under which royalties
                                  may be payable.  Finally, the Company's
                                  oxalate diagnostic test may require a license
                                  from Roche Diagnostics for the use of PCR
                                  technology.


<PAGE>

Trademarks owned by the Company:
--------------------------------

o        IXION (R)
o        XENTRIX TM
o        Charitable Benefit Warrant (R)
o        Ox-Control TM



<PAGE>
                                  EXHIBIT 2.12
                                  ------------

                        Insurance Policies not in Effect




                                     None.

(The Company believes that its insurance policies are on a "claims made" basis.)



<PAGE>
                                  SCHEDULE 2.13
                                  -------------

          Law suits, Actions, Investigations, etc. against the Company



                                     None.


<PAGE>


                             SCHEDULE 2.13 continued
                             -----------------------

Pending Claims, Investigations, Charges, etc. , relating to Wages, Compensation,
                             Equal Employment, etc.





                                     None.


<PAGE>


                                  SCHEDULE 2.14
                                  -------------

             Description of Real Property Leased or Owned by Company




      5,016 square feet of combined office and laboratory space located at
13709 Progress Boulevard, Alachua, Florida; includes $30,698.00 in improvements.


<PAGE>

                                  SCHEDULE 2.15
                                  -------------

                Agreements/Contracts to which Company is a Party



a)  Material contracts which cannot be cancelled:

None.

b) Contractual obligation to officers or directors of the Company:

o  Charitable Benefit Warrant Agreement, dated as of December 10, 1997 with
   David C. Peck
o  Stock Option grants at various dates to Messrs. Gaines, Peck, Peck
   and Ms.  Ramsey.
o  Consulting  Agreement  with  David C. Peck dated July 1, 1996
o  Employment Agreement with David C. Peck, dated August 1994.
o  Note  Purchase  Agreement,  dated  as  of  September  13,  1996  (piggyback
   registration  rights for shares issued to officers  upon  conversion of the
   convertible debentures, expiring August 31, 2006.)
o  Employment Agreement with Weaver H. Gaines dated August 31, 1994.
o  Consulting Agreement with Ammon B. Peck, dated March 2000
o  Convertible Promissory Note with Weaver H. Gaines, dated March 31, 1993
o  Convertible Promissory Note with David C. Peck, dated October 15, 1993
o  Demand Promissory Note, Bridge Loan with Weaver H. Gaines, dated April 15,
   1996
o  Demand Promissory Note, Bridge Loan with David C. Peck, dated April 15, 1996
o  Deferred Compensation Plan Agreement with Weaver H. Gaines, dated January 1,
   1994
o  Deferred Compensation Plan Agreement with Ammon B. Peck, dated June 1, 1994
o  Deferred Compensation Plan Agreement with David C. Peck, dated April 1, 1994
o  Consulting Agreement with Thomas P. Stagnaro, dated September 21, 1998
o  University of Florida Monitoring Agreement regarding Dr. Ammon B. Peck's
   conflict of interest

c) - g)
-------

None.



<PAGE>

                                  SCHEDULE 2.16
                                  -------------

                               Condition of Assets




                                     None.


<PAGE>


                                  SCHEDULE 2.17
                                  -------------

  Accounts and Note Receivables not created in the Ordinary Course of Business




                                     None.


<PAGE>


                                  SCHEDULE 2.18
                                  -------------

  Permits, Licenses, Approvals, etc. that Company currently does not have that
               would negatively affect the ability to run Business




                                     None.

<PAGE>


                                  SCHEDULE 2.19
                                  -------------

                             List of Company's Banks




          o        Sun Trust Bank, North Florida, NA

          o        The Unified Funds


<PAGE>

                                  SCHEDULE 2.20
                                  -------------

 Assets and Intellectual Property owned by Officers, Directors, Shareholders or
                              Affiliates of Company



Milton J. Allison,  a member of the Company's  Scientific  Advisory  Board and a
shareholder  of the  Company,  is the licensor of certain  patent  rights to the
Company  as  disclosed  in  Schedule  2.11  relating  to  U.S.  Application  No.
09/083,362  and U.S.  Application  No.  09/500,500 and foreign  filings  related
thereto.


<PAGE>

                                  SCHEDULE 2.21
                                  -------------

             Salary Information of Company's Officers and Directors

Salaries:
---------

         Gaines      $95,000 base salary
         Peck, AB    $50,000  consulting  fee
         Peck, DC    $60,000  consulting  fee
         Sidhu       $60,000 base salary
         Ramsey      $45,000 base salary


Incentive Compensation Plan:
----------------------------

         In 1994, the Company adopted an incentive compensation plan (the "Bonus
Plan") for all employees of the Company,  pursuant to which participants will be
awarded cash bonuses (if the Company has  sufficient  cash to prudently pay such
bonuses)  or  deferred  bonuses  (if the  Company  can not  prudently  pay  cash
bonuses), based on the performance of the Company during the previous 12 months.
Bonuses  will be paid based on the base salary in effect at the end of the prior
fiscal  year  to all  qualified  persons  on the  payroll  at  the  date  of the
declaration  of the bonus.  Bonuses will be prorated for any person not employed
during the entire previous 12-month period.

         Awards levels may range as follows:

         -senior vice president or above: up to 50% of  participant' base salary
          or consulting fee.
         -vice presidents: up to 30% of participants base salary or consulting
          fee.

         Based on the  results  for  1998-1999,  the Audit & Benefits  Committee
awarded  69% of the  maximum  bonus to the  eligible  officers,  employees,  and
consultants, based on 1998 base salaries or fees paid, as follows:

         Gaines            34.5% of base salary or $32,775
         Peck, D.          34.5% of base salary or $20,700
         Peck, A.          34.5% of base salary or $17,250
         Sidhu             13.8% of base salary or $7,176
         Ramsey            10.4% of fees paid

Directors are paid no cash salaries, but receive awards under the Board Retainer
Plan and the 1994 Stock Option Plan. They do not receive bonuses.

<PAGE>

                                  SCHEDULE 2.22
                                  -------------

   Employee Pension Benefit Plans within s.3(2)(A) of ERISA, any Policies or
       Plans that Provide for Vacation, Severance and Leave Benefits, and
       Discretionary Employer Contributions that have not been Contributed
                         to Company's 401(K) Plan, etc.




     o        No ERISA plans

     o        The employment contracts with Weaver Gaines and David Peck.

     o        The Company has workers'  compensation  insurance  providing  for
              benefits for injured workers.

     o        Company policy provides for up to 25 days of vacation (depending
              on service), up to 12 days of sick leave annually, and 11 paid
              holidays.

     o        The  Company  has  agreed  to  pay  for  health  insurance  for
              certain employees, and intends to propose a Company health plan to
              the board.

     o        There is an informal  severance  policy providing two weeks of
              salary per year of service.

     o        The 1994 Stock Option Plan and the Board Retainer Plan may be
              deemed to provide benefits to employees.


<PAGE>

                                  SCHEDULE 2.23
                                  -------------

                                     Brokers



                                      None.


<PAGE>

                                  SCHEDULE 2.24
                                  -------------

                       Labor Discussions, Agreements, etc.




                                     None.


<PAGE>

                                  SCHEDULE 2.25
                                  -------------

             Other Names under which Company has Conducted Business




                                     None.
<PAGE>

                                  SCHEDULE 3.1

  Consents of Governmental or Other Regulatory Agencies to Enable Purchaser to
                              Carry out Transaction




                                     None.


<PAGE>
                                  EXHIBIT 1.1
                                  -----------


                             SHAREHOLDERS' AGREEMENT


     THIS  SHAREHOLDERS'  AGREEMENT  ("Agreement"),  made and entered into as of
this 14th day of  July,  2000 (the  "Effective  Date")  by and among  IXION
BIOTECHNOLOGY,  INC., a Delaware corporation (the  "Corporation"),  and Q-MED AB
(publ), a Swedish company  ("Q-MED"),  QVESTOR LLC, a Delaware Limited Liability
Company  ("QVESTOR"),  AMMON B. PECK Ph.D and  WEAVER H.  GAINES,  (referred  to
herein   individually   as   the   "Shareholder"   and   collectively   as   the
"Shareholders"), as follows:

                              W I T N E S S E T H:
                              --------------------

       WHEREAS,  the  Shareholders  are  now  the  owners  of a  majority  of
the Corporation's outstanding shares of stock (the "Shares"); and

       WHEREAS,  the Shareholders desire to promote their mutual interests and
the interest of the Corporation by imposing certain restrictions and obligations
on  themselves,  the  Corporation,  and the  Shares  pursuant  to the  terms and
conditions of this Agreement.

       NOW,  THEREFORE,  in  consideration  of the  premises and of the mutual
covenants  set forth herein and for other good and valuable  consideration,  the
receipt  and  sufficiency  of which are  hereby  acknowledged,  intending  to be
legally bound, the parties agree as follows:

                                      TERMS
                                      -----

       1.      DEFINITIONS

       For  purposes of this  Agreement,  the  following  terms shall have the
meaning indicated below:

       "Dispose Of" shall mean pledge,  hypothecate,  give, assign,  encumber,
sell,  grant an option  with  respect  to, or  otherwise  transfer,  other  than
pursuant to a plan of merger or consolidation,  to anyone,  whether or not it is
then a Shareholder;  provided, however, that a pledge by all Shareholders of all
Shares to secure  future  financing  for the  Corporation  shall not be deemed a
disposition of Shares.

       2.       RESTRICTION ON DISPOSITION

                (a) While this  Agreement  is in force and  effect,  no
Shareholder  shall  Dispose  Of its  interest  in any of the Shares now or later
owned by it, except by the terms of this  Agreement.  Any attempted or purported
transfer of an ownership  interest in violation of this Agreement  shall be void
and shall constitute an

<PAGE>

abandonment  of the  Shareholder's  Shares.  No transfer of ownership  interests
pursuant to this Agreement  shall be recognized by the  Corporation  until it is
duly  entered upon the books and records of the  Corporation  and all indicia of
ownership are changed accordingly.

                (b) The Share  certificates  shall bear the following  legend or
a legend to the following effect:

          These  shares have not been  registered  under the  Securities  Act of
          1933,  and may not be  sold,  transferred,  pledged,  or  hypothecated
          except  pursuant  to  registration  under such Act or  pursuant  to an
          available  exemption from registration under said Act. The transfer of
          these shares is further  restricted under the terms of a Shareholders'
          Agreement  dated  as of July  14,  2000  between  the  holder  of this
          certificate  and the  Corporation,  a copy of  which is on file at the
          principal office of the Corporation. No transfer will be recognized by
          the Corporation  until, as the case may be, counsel to the Corporation
          is satisfied  there is no violation of the Securities Act of 1933, the
          other shareholders consent to the transfer, or both.

                (c) By virtue of such legend and with notice,  any  transferee
of the Shares of the Corporation becomes a party to, and is bound by, this
Agreement.

     3.         DISPOSITIONS OF SHARES

                (a)  Restriction.  No  Shareholder  shall  Dispose Of his or its
Shares,  except  pursuant  to the terms of this  Agreement,  provided  that this
section 3 shall not apply to (i) bona fide gifts or bequests by any  Shareholder
to a third person or member of the Shareholder's  family or (ii) bona fide gifts
or bequests by a  Shareholder  to a charitable  institution  or not-for-  profit
entity, where the cumulative total of subsections (i) and (ii) do not exceed ten
percent of the Shareholder's fully diluted holdings of the Shares measured as of
the date of the gift or bequest.

                (b)  Corporation's  Option to Purchase  Shares.  A  Shareholder
(the "Offering Shareholder") who desires to Dispose Of any Shares in response to
a bona fide offer from a third party (the "Third Party Offer") shall first offer
such Shares to the Corporation and the other  Shareholders at the same price and
on the same terms contained in the Third Party Offer.  The Offering  Shareholder
shall  give a  notice  ("Notice")  signed  by the  Offering  Shareholder  to the
Corporation  and on the same day give Notice to the other  Shareholders  of such
Offering  Shareholder's desire to Dispose Of his or its Shares. The Notice shall
specify the number of Shares (the  "Offered  Shares") the  Offering  Shareholder
intends to Dispose Of and the purchase  price and terms of any offer to purchase
the Shares  made by the Third  Party  Offeror.  The  Corporation  shall have the
irrevocable and exclusive first option, but not the obligation,  to purchase all
or, subject to paragraph 3(c) below, a
                                       2
<PAGE>
part of the  Offered  Shares,  at the  price  and on  substantially  the same or
comparable  terms to those set forth in the  Notice,  provided  the  Corporation
gives  notice of its  election to purchase to the  Offering  Shareholder  within
thirty (30) days after the Corporation receives the Notice.

                (c) Other  Shareholders'  Option to Purchase Shares. If the
Corporation  does not elect to purchase all of the Offered Shares covered by the
Notice as provided in paragraph  3(b),  then,  subject to paragraph  3(e),  each
Shareholder  other than the Offering  Shareholder shall have the irrevocable and
exclusive second option,  but not the obligation,  to purchase from the Offering
Shareholder that part of the Offered Shares that the Corporation has not elected
to  purchase,  pro rata to its  holdings  of Shares on the date the  Corporation
received the Notice (exclusive of the Shares offered for sale or otherwise owned
by the Offering  Shareholder).  Each Shareholder  who elects to purchase all or
a part of its pro rata  portion of the Offered  Shares shall give notice of such
election to the Offering Shareholder and the other Shareholders, as the case may
be,  within  forty-five  (45)  days  after  the  receipt  of the  Notice  by the
Corporation.  Each  such  notice  shall  state the  number  of Shares  which the
Shareholder  giving the notice elects to purchase.  The purchase  price shall be
the same as set forth in the Third Party Offer.

                    (i) If any Shareholder fails to exercise its right to
purchase  its full pro rata  portion of the  Offered  Shares,  each of the other
Shareholders  who has given  notice of election  to  purchase  its full pro rata
portion of the Offered  Shares shall have an additional  ten (10) days after the
expiration  of such  forty-five  (45) day  period in which to give the  Offering
Shareholder and the other Shareholders, further notice (the "Further Notice") of
its  election to purchase all or a part of the  Remaining  Shares (as defined in
(ii) below).  Each Further  Notice shall state the number of  additional  Shares
that the  Shareholder  giving the Further Notice elects to purchase.  The Shares
shall be apportioned  among those  Shareholders  who have given a Further Notice
according to the procedure described below or in such different portions as such
Shareholders may agree among themselves. Each of the Participating Shareholders,
as defined in (ii) below,  shall be  apportioned  (1) that number of  additional
Shares that it elected to  purchase  in its Further  Notice and which it has not
yet been  apportioned  pursuant to this paragraph  3(c)(i),  or (2) its pro rata
portion of the Unpurchased Shares (as defined in (ii) below), whichever is less.
If the  apportionment  is followed and there  remain at least one  Participating
Shareholder and any Unpurchased  Shares, the procedure  described above shall be
repeated.

                    (ii) For purposes of paragraph 3(c)(i), the following
definitions shall apply:

                         (1) The "Remaining  Shares" shall be the Offered Shares
that the Corporation and the Shareholders have not elected to purchase.

                                       3

<PAGE>

                         (2) A "Participating Shareholder" shall be a
Shareholder who has given a Further Notice and who has not yet been apportioned
pursuant to paragraph 6(c)(i) that number of additional Shares that it elected
to purchase in its Further Notice.

                         (3)  "Unpurchased  Shares" shall be the Remaining
Shares that have not yet been apportioned to Participating Shareholders pursuant
to paragraph 3(c)(i).

                         (4) A "Participating  Shareholder's Pro Rata Portion"
of the Unpurchased  Shares shall be the number of Unpurchased  Shares multiplied
by the fraction formed by dividing the number of Shares that such  Participating
Shareholder  held on the date the Corporation  received the Notice by the number
of  Shares  that  all of the  Participating  Shareholders  held on the  date the
Corporation received the Notice.

                (d)     Effect of an Election to Purchase.  The  Corporation
and each  Shareholder  giving notice of election to purchase  Shares pursuant to
paragraph  3(b) or 3(c),  respectively,  shall be obligated  severally  (but not
jointly)  to  purchase   from  the  Offering   Shareholder,   and  the  Offering
Shareholder,  provided the Corporation, the other Shareholders, or a combination
of the  Corporation  and the other  Shareholders  elect to  purchase  all of the
Offered  Shares,  shall be  obligated  to sell to the  Corporation  or the other
Shareholders, or the Corporation and the other Shareholders, as the case may be,
the number of Offered Shares stated therein,  at the price and on  substantially
similar terms to those contained in the Third Party Offer.


                (e)     Consequences  if Not All  Shares  are to be  Purchased.
If an  Offering  Shareholder  gives  Notice and the  Corporation,  and the other
Shareholders do not elect,  pursuant to paragraphs 3(b) and 3(c),  respectively,
to purchase all of the Offered  Shares,  the Offering  Shareholder  may elect to
sell to the  Corporation,  if it has  elected to  purchase  part of the  Offered
Shares and to the Shareholders, if any, who have elected to purchase part of the
Offered  Shares,  the aggregate  number of such Shares which the Corporation and
such  Shareholders  have  elected to purchase at the price and on  substantially
similar terms to those  contained in the Third Party Offer.  If the  Corporation
and the other  Shareholders  have failed to elect to purchase all of the Offered
Shares pursuant to the provisions  above, the Offering  Shareholder may sell the
Offered  Shares (i) to the third party  offeror  identified in the Notice at the
price and on the terms  contained  in the Third Party Offer or (ii) to any other
third party at the identical terms set forth in the Third Party Offer. Such sale
to a third party must be closed within thirty (30) days after nonelection by the
Corporation and the other  Shareholders.  If such sale is not closed within such
time  period,  the  sale of the  Offering  Shareholder's  Shares  will  again be
governed by the provisions of this section 3.

                                       4

<PAGE>

                (f)     Restrictions  on Third  Party  Purchaser.
Notwithstanding  an Offering  Shareholder's  right to sell  Offered  Shares to a
third party as set forth above,  the Offering  Shareholder  may not sell Offered
Shares to any competitor or potential competitor of the Corporation.


                (g)     Continuing Restriction on Remaining Shares. If any
Shares have been offered for sale  pursuant to this section 3 and that offer has
not been finally  accepted in accordance  with the provisions of this section 3,
then such Shares still owned by the Offering Shareholder shall remain subject to
the terms of this Agreement.


                (h)     Q-MED  and  QVESTOR  Exception.   Notwithstanding   the
above  provisions  of this Section 3, Q-MED and QVESTOR may sell,  transfer,  or
assign their respective Shares of the Corporation to any subsidiary or affiliate
of Q-MED or any  business  entity in which  Q-MED owns an  interest in excess of
fifty percent (50%),  without first  offering such shares to the  Corporation or
the other shareholders.

     4.         DEATH, DISSOLUTION OR DISABILITY OF SHAREHOLDER

                (a)     Death or Dissolution of Shareholder

                       (i)      Option to  Purchase  Shares on Death or
Dissolution of Shareholder.  Subject to the terms of section 4 (d) hereof,  upon
the  death  of a  Shareholder  (a  "Decedent")  or  upon  the  dissolution  of a
Shareholder  which is an Entity,  whether by  operation of law,  judicially,  or
voluntarily (a "Dissolved  Shareholder") during the term of this Agreement,  the
Corporation and the remaining Shareholders ("Remaining Shareholders") shall have
the irrevocable  and  exclusive  successive  options,  but not the  obligation,
subject  to  subsection   4(a)(vi)  hereof,   to  purchase,   and  the  personal
representative  of the Decedent or the  Trustee(s) of the Dissolved  Shareholder
shall sell all of the Decedent's or Dissolved  Shareholder's Shares owned at the
date of death or  dissolution,  at the price and in the manner set forth in this
Agreement. The provisions of this section will apply to any Shares held by joint
tenancy only upon the death of both joint tenants.

                       (ii)  Corporation's  First Option to Purchase Shares. The
Corporation  shall have the  irrevocable  and exclusive first option to purchase
all, but not less than all, of the Decedent's or Dissolved Shareholder's Shares,
provided  the  Corporation  gives  notice of its  election  to  purchase  to the
personal  representative  of the  Decedent or the  Trustee(s)  of the  Dissolved
Shareholder  within  thirty  (30)  days  after  the date of  appointment  of the
personal  representative of the Decedent's estate ("Date of Appointment") or the
date of dissolution of the Dissolved  Shareholder  (the "Date of  Dissolution").
The purchase  price to be paid by the  Corporation  shall be

                                       5

<PAGE>

equal to the Agreed  Value of the Shares on the date of death of the Decedent or
the Date of Dissolution.

                       (iii) Life Insurance.  The Corporation may, but is not
obligated to, secure life  insurance on the  Shareholders  from a life insurance
company  selected by the  Corporation.  This  insurance need not be in an amount
necessary to pay the entire purchase price for the Shares at death.  Each of the
Shareholders agrees to do everything necessary to cause insurance policies to be
issued  pursuant  to this  Agreement,  if the  Corporation  elects to do so. The
Corporation,  which shall be the owner of the life insurance policies, agrees to
pay the  premiums  as they become  due,  and each  policy  shall be the sole and
absolute  property of the Corporation.  Any dividends  payable upon the policies
prior to maturity by the death of the insured  Shareholder  shall be paid to the
Corporation in cash or disposed of as the Corporation may direct. This Agreement
shall  extend to and include  all  additional  life  insurance  policies  issued
pursuant to this Agreement.

                      (iv) Shareholders' Second Option to Purchase Shares. If
the  Corporation  does not  elect to  purchase  the  Shares of the  Decedent  or
Dissolved  Shareholder  as  provided in  subsection  4(a)(ii),  then  subject to
subsection 4(a)(vi),  the Remaining  Shareholders shall have the irrevocable and
exclusive second option,  but not the obligation,  to purchase from the personal
representative  of the Decedent or the Trustee(s) of the Dissolved  Shareholder,
that part of the Shares, pro rata, to such Remaining  Shareholder's  holdings of
Shares on the date of death of the  Decedent  or the Date of  Dissolution.  Each
Remaining Shareholder who elects to purchase all or part of its pro rata portion
of the  Decedent's or Dissolved  Shareholder's  Shares shall give notice of such
election to the personal representative of the Decedent or the Trustee(s) of the
Dissolved  Shareholder and to the Remaining  Shareholders within sixty (60) days
after the Date of Appointment or the Date of Dissolution.  The purchase price to
be paid shall be equal to the Agreed Value of the Shares on the date of death of
the Decedent or the Date of Dissolution.

                              (aa)    If any  Remaining  Shareholder  fails to
exercise  its right to purchase  its full pro rata  portion of the Shares of the
Decedent or the Dissolved Shareholder,  each Remaining Shareholder who has given
notice of election to  purchase  its full pro rata  portion of the Shares of the
Decedent or the Dissolved  Shareholder shall have an additional twenty (20) days
after  the  expiration  of such  sixty  (60) day  period in which to give to the
personal  representative  of the  Decedent or the  Trustee(s)  of the  Dissolved
Shareholder  and the other Remaining  Shareholders further notice (the "Further
Notice") of its election to purchase all or a part of the Shares of the Decedent
or the  Dissolved  Shareholder.  Each  Further  Notice shall state the number of
additional  shares that the  Remaining  Shareholder  giving the  Further  Notice
elects to  purchase.  The Shares  shall be  apportioned  among  those  Remaining
Shareholders  who  have  given  a  Further  Notice  according  to the  procedure
described  below or in such different  portions as such  Shareholders  may agree
among themselves. Each of the

                                       6

<PAGE>

Participating  Shareholders  shall be apportioned  (1) that number of additional
shares of Shares that it elected to purchase in its Further Notice and which has
not yet been apportioned pursuant to this subsection 4(a)(iv)(aa) or (2) its pro
rata portion of the Unpurchased Shares,  whichever is less. If the apportionment
is followed  and there  remain at least one  Participating  Shareholder  and any
Unpurchased Shares, the procedure described above shall be repeated.

                             (bb)  For purposes of subsection 4(a)(iv)(aa),
the following definitions shall apply:

                                   a.     The  "Remaining  Shares" shall be the
Offered Shares that the Shareholders have not elected to purchase.

                                   b.     A "Participating  Shareholder" shall
be a Shareholder  who has given a Further  Notice and who has not yet been
apportioned pursuant to subsection 4(a)(iv)(aa) that number of additional shares
that he elected to purchase in his Further Notice.

                                   c.     "Unpurchased  Shares" shall be the
Remaining   Shares  that  have  not  yet  been   apportioned  to   Participating
Shareholders pursuant to subsection 4(a)(iv)(aa).

                                   d.     A  "Participating   Shareholder's Pro
Rata Portion" of the  Unpurchased  Shares shall be the number of Unpurchased
Shares  multiplied  by the  fraction  formed by dividing the number of shares of
Shares that such  Participating  Shareholder  held on the Date of Appointment or
Date  of  Dissolution  by  the  number  of  shares  of  Shares  that  all of the
Participating   Shareholders  held  on  the  Date  of  Appointment  or  Date  of
Dissolution.

                      (v)      Effect of an Election.    The  Corporation  or
each  Shareholder  giving  notice of  election to  purchase  Shares  pursuant to
subsection 4(a)(ii) or 4(a)(iv), respectively, shall be obligated severally (but
not jointly) to purchase from the personal representative of the Decedent or the
Trustee(s) of the Dissolved Shareholder,  and the personal representative of the
Decedent  or  the  trustee(s)  of  the  Dissolved   Shareholder,   provided  the
Corporation,  or such Remaining Shareholders have elected to purchase all of the
Offered Shares, shall be obligated to sell to the Corporation, or such Remaining
Shareholders, as the case may be, the number of shares of Shares of the Decedent
or Dissolved  Shareholder  stated therein,  at the price determined  pursuant to
subsection 4(a)(ii) or 4(a)(iv).

                      (vi)     Consequences  if All Shares are Not to be
Purchased. If the Corporation or the Remaining Shareholders do not elect,
pursuant to subsections 4(a)(ii) and 4(a)(iv), to purchase all of the Shares of
the Decedent or the Dissolved Shareholder, the personal representative of the
Decedent or the Trustee(s) of the Dissolved Shareholder may elect to sell to the
Remaining

                                       7

<PAGE>

 Shareholders, if any, who have elected to purchase part of the Shares
of the Decedent or the Dissolved Shareholder, the aggregate number of such
shares which such  Shareholders have elected to purchase at the price and on the
terms  and  conditions  determined  pursuant  to  subsection  4(a)(iv).  If  the
Corporation or the Remaining  Shareholders  have failed to elect to purchase all
of  the  Offered  Shares  pursuant  to  the  provisions   above,   the  personal
representative  of the Decedent or the Trustee(s) of the Dissolved  Corporation,
prior to any transfer of the Shares to a third party,  shall again offer to sell
the Shares at a purchase price equal to the price offered by the bona fide third
party purchaser, first to the Corporation and then to the Remaining Shareholders
in the same manner as set forth in Subsections 3(b) - 3(e) hereof.

                (b)      Disability of Shareholder

                        (i)      Option to  Purchase  Shares  upon  Disability
of Shareholder. Subject to the terms of section 4 (d), below, if a Shareholder
becomes physically or mentally unable to perform his or her regular and
customary duties to the Corporation for a continuous period of [one hundred
(100)] days (the "Date of Disability"), such Shareholder shall be considered
totally and permanently disabled (a "Disabled Shareholder"). The Corporation and
the Remaining Shareholders shall have the irrevocable and exclusive successive
options, but not the obligation, to purchase and the Disabled Shareholder, or
such Shareholder's guardian or other person possessing the legal power to act on
such Shareholder's behalf to satisfy his contractual obligations
("Representative"), shall sell all of the Shares owned by the Disabled
Shareholder at the Date of Disability at the price and in the manner set forth
in this Agreement.

                        (ii)     Corporation's  First Option to Purchase Shares.
Within thirty (30) days after the Date of Disability, the Corporation may elect,
at its option, to purchase all of the Shares owned by the Disabled Shareholder
in the same manner as set forth in subsection 4(a)(ii) hereof. The purchase
price of the Shares shall equal its Agreed Value as of the Date of Disability.

                        (iii)    Disability  Insurance.  In order to assure
sufficient funds are available to pay for a purchase by the Corporation of a
Shareholder's Shares in the event of his or her disability, the Corporation may,
but is not obligated to, secure disability insurance from a company selected by
the Corporation. Each of the Shareholders agrees to do everything necessary to
cause disability insurance policies to be issued pursuant to this Agreement, if
the Corporation elects to do so. The Corporation, which shall be the owner of
the disability insurance policies, agrees to pay the premiums as they become due
and each policy shall be the sole and absolute property of the Corporation. This
Agreement shall extend to and include all additional disability insurance
policies issued pursuant to this Agreement.

                                       8

<PAGE>

                        (iv)     Shareholders  Second Option to Purchase Shares.
If the Corporation does not elect to purchase the Shares owned by the Disabled
Shareholder, the Remaining Shareholders shall have the irrevocable, and
exclusive second option, but not the obligation, to purchase from the Disabled
Shareholder that part of the Disabled Shareholder's Shares, pro rata to its
holdings of Shares on the Date of the Disability in the manner provided in
subsection 4(a)(iv). The purchase price to be paid by the Remaining Shareholders
shall equal the Agreed Value of the Shares as of the Date of Disability.

                        (v)  Consequences  if all Shares are Not to be
Purchased. If the Corporation or the Remaining Shareholders do not elect,
pursuant to subsections 4(b)(ii) and 4(b)(iv), respectively, to purchase all of
the Shares of the Disabled Shareholder, the Disabled Shareholder may elect to
sell to the Remaining Shareholders, if any, who have elected to purchase part of
the Shares of the Disabled Shareholder, the aggregate number of shares of such
Shares which such Remaining Shareholders have elected to purchase at the price
determined pursuant to subsection 4(b)(iv). If the Corporation or the Remaining
Shareholders have failed to elect to purchase all of the Shares of the Disabled
Shareholder pursuant to the above provisions, the Disabled Shareholder may sell
its stock to a third party within thirty (30) days thereafter at the Agreed
Value: (i) only on the same terms and conditions as the Shares have been offered
to the Corporation and Remaining Shareholders and (ii) only if the purchaser
agrees in writing to be bound by all of the terms and conditions of this
Agreement. If such sale is not closed within thirty (30) days after nonelection
by the Corporation and Remaining Shareholders, the sale of the Disabled
Shareholder's Shares shall again be governed by provisions of this section 4.

                (c) Continuous  Restriction on Remaining Shares. If any Shares
have been  offered for sale  pursuant  to this  section 4 and that offer has not
been finally  accepted in accordance with the provisions of this section 4, then
the Shares  still  held by the  personal  representative  of the  Decedent,  the
Trustee(s) of the Dissolved Shareholder or the Disabled Shareholder shall remain
subject to the terms of this Agreement.

                (d)  Execution  of  Voting  Trust  Agreement.  In the event of
Shareholder's death,  dissolution or disability,  the personal representative of
the  Decedent  or  the   Trustee(s)  of  the  Dissolved   Shareholder,   or  the
Shareholder's Representative, within ten (10) days after receiving notice of the
election to purchase by the Corporation or the Remaining  Shareholders  pursuant
to the options set forth in section 4 (a) or (b), may take the following actions
, in which case the terms of section 4 (a) or (b) shall not apply:

                    (i)      Provide   notice  to  the   Corporation   and
Remaining Shareholders , set forth herein, that such personal representative of
the Decedent, or Trustee of the Dissolved Shareholder, or Shareholder's

                                       9

<PAGE>

Representative has elected to establish a Voting Trust Agreement, substantially
in the form of Exhibit 1 hereto, under which QVESTOR will be appointed as
Trustee and shall have the right to exercise, in person or by proxy, all of such
Shareholder's voting rights and powers in respect of the Shares registered in
the name of the Trustee, and to take part in or consent to any and all corporate
or shareholder action; and

                    (ii)     Simultaneously with the execution of the Voting
Trust Agreement, or as soon as reasonably practicable thereafter, deposit with
the Trustee, the certificate or certificates for their respective Shares,
together with instruments duly executed for the transfer of their shares to the
Trustee. Pending the delivery of such instruments, each Shareholder hereby
transfers the Shares to the Trustee. The Shares shall be vested in the Trustee
and shall be transferred to the name of the Trustee on the books of the Company,
and the Trustee shall issue and deliver a Certificate to each such personal
representative of the Decedent, Trustee of the Dissolved Shareholder or
Shareholder's Representative representing his beneficial ownership of the
deposited Shares (a "Certificate"); and

                    (iii)  Complete the actions  required by  subsections
(d)(i) and (ii) within ninety (90) days following the notice by the Corporation
or Remaining Shareholders of their election to purchase the Shareholder's
Shares.

         5.       VOTING  AGREEMENT

         Each  of  the  parties  hereto  agrees  to  nominate,   and  cause  the
Corporation to nominate, for election to the Corporation's Board of Directors at
any special or annual meeting of stockholders of the Corporation,  four nominees
proposed by Shareholders QVESTOR and Q-Med, ("Nominees") and each of the parties
hereto agrees to vote, at any special or annual meeting of the  stockholders  of
the Corporation, to elect such Nominees to the Corporation's Board of Directors.

         6.       AGREED VALUE OF SHARES

         The Corporation and the Shareholders stipulate that the Agreed Value of
each  Share  for  purposes  of this  Agreement  shall be the  value set forth on
Schedule  "A"  attached  hereto  from time to time.  The Agreed  Value  shall be
established  not less often than once each calendar year by the  Shareholders at
the Corporation's Annual Meeting and shall be set forth on a new Schedule "A" to
be attached to this  Agreement.  If for any reason the  Shareholders  shall have
failed  to  stipulate  the value for the year in which a  Shareholder  dies,  is
dissolved,  becomes  disabled,  is terminated or announces its intention to sell
its Shares, the last previously stipulated value shall control. In the event the
Shareholders  have failed to stipulate  the value of the Shares for more than 18
months  and the  Agreed  Value of the  Corporation's  Shares is  disputed  by an
Offering Shareholder,  the personal  representative of the deceased Shareholder,
the  trustee(s) of a dissolved  Shareholder  or a Disabled  Shareholder  covered
under this  Agreement  (hereinafter

                                       10

<PAGE>

referred  to  collectively  as the  "Selling  Shareholders"),  the  value of the
Corporation's  Shares will be set by  appraisal.  The Selling  Shareholders,  at
their expense,  shall have the right to choose an MAI appraiser to independently
appraise the business and worth of the  Corporation  as of the date of the event
which created a  requirement  or option to purchase the Shares.  Such  appraisal
shall then be presented to the Board of Directors of the  Corporation  for their
approval.  If a  majority  of the Board  approves  the  amount of the  appraisal
prepared by the Selling  Shareholders'  MAI, such appraisal  shall be deemed the
fair market value of the Corporation  ("FMV") from which the Agreed Value of the
Shares will be determined for purposes of said transaction. Should a majority of
the Corporation's  Board of Directors fail to approve the appraisal  prepared by
the Selling  Shareholders'  MAI, the Board may, at its expense,  choose a second
MAI to independently  appraise the business and worth of the  Corporation.  Once
the Board's MAI has  completed  its  appraisal,  the  appraisals of the two MAIs
shall be  averaged  to  determine  the FMV of the  Corporation  unless  the MAIs
disagree on FMV by an amount  exceeding  ten percent  (10%) of the highest  such
appraisal.  If the difference in the  appraisals  does exceed ten percent (10%),
the two MAIs may  designate a third MAI to perform an  independent  appraisal of
the  company  and  assign  a FMV to its  Shares.  The  cost of the  third  MAI's
appraisal  shall  be  borne  equally  by  the  Selling   Shareholders   and  the
Corporation,  and the FMV determined by such  appraiser  shall be binding on all
parties.  Once the FMV of the Corporation is established in accordance with this
section,  the Agreed Value for said  transaction  will be calculated by dividing
the FMV of the Corporation by the number of shares of Shares  outstanding at the
date when the event  occurred  which created a requirement or option to purchase
the Shares.

         7.       CLOSING

         The  Corporation  shall set a reasonable  time after  acceptance by the
Corporation  and/or  the  other  Shareholders  of  an  offer  from  an  Offering
Shareholder for closing a purchase under this Agreement.

         8.       DELIVERY OF SHARES

         Upon the payment to the  Shareholder  of the purchase price as provided
in this Agreement, the Shareholder shall assign and deliver the Shares purchased
under this Agreement to the  Corporation  (as transfer  agent) free and clear of
all liens, charges, and encumbrances of any nature whatsoever, duly endorsed for
transfer.

         9.       DOCUMENTARY STAMPS

         Whenever any Shares are sold pursuant to this Agreement,  the party who
triggers the sale of Shares must purchase and affix to the Share certificate any
documentary stamps required by Florida law.

                                       11

<PAGE>

         10.      PIGGY-BACK REGISTRATION RIGHTS

         If the  Corporation  elects to  register  any of its  Shares  under the
Securities Act of 1933 and/or  applicable state securities laws, the Corporation
shall provide the  Shareholders  notice of such  election,  and,  subject to the
approval of the lead  underwriter  in any such  registration,  the  Shareholders
shall be entitled to  "piggy-back"  registration  rights for not less than fifty
percent  ) of  their  Shares  at no  expense,  other  than  applicable  broker's
commission.

         11.      DOCUMENTATION

         While  employed  by  the  Corporation,  each  employee  and  consultant
Shareholder shall prepare and maintain adequate and current documentation of his
work for the Corporation.  Upon any termination of such employment, the employee
Shareholder  shall leave  reasonable and orderly  documentation  of his work and
cooperate  fully with the  Corporation  in  connection  with the training of any
person or persons employed to perform the employee  Shareholder's duties and the
orderly and smooth transfer of the employee  Shareholder's duties to such person
or persons.

         12.      TERMINATION OR MODIFICATION OF AGREEMENT

                  (a)    This Agreement will terminate upon the occurrence of
any of the following events:

                         (i)      cessation of the Corporation's business;

                         (ii)     receivership, filing for relief under the
                                  Bankruptcy Code, or dissolution of the
                                  Corporation;

                         (iii)    the written agreement of all parties hereto;

                         (iv) the initial public offering of the  Corporation's
                              shares on a listed stock exchange; or

                         (v)  the  sale  of  all or  substantially  all of the
                              stock  or  assets  of the Corporation.

                  (b) This Agreement may only be modified by the written
agreement of all parties hereto. Unanimous approval of all Shareholders shall be
required for any amendment to be effective.

                                       12

<PAGE>

         13.      ABANDONMENT

         If a  Shareholder  attempts  or  purports  to attempt to Dispose Of its
Shares in violation of this Agreement,  then the Shareholder  shall be deemed to
have abandoned its ownership  interest in its Shares,  and the Corporation shall
be empowered (but not obligated) to redeem such Shareholder's ownership interest
in its Shares.  The redemption price in the event of an abandonment  shall be no
greater  than the  price  paid for the  Shares  by the  abandoning  Shareholder,
without credit or attribution of interest, or the then-current book value of its
Shares,  whichever  sum is less,  said lower  value  being a  disincentive  to a
Shareholder to abandon its interest in its Shares.  The  redemption  price under
this paragraph shall be paid to the abandoning  Shareholder over a period of two
(2)  years  in  annual  installments  beginning  one  year  after  the  date  of
abandonment, with no interest accruing. Each Shareholder which is a party hereto
hereby  irrevocably  constitutes  and  appoints  the  Shareholders  who have not
abandoned their interests in their Shares as its  attorneys-in-fact to terminate
its  ownership  interest in the  Corporation  in the event it shall  abandon its
interest as provided  herein,  and to execute,  file of record,  and record,  as
appropriate, such documents and instruments as may be required to effectuate the
transfer of its ownership interest.

         14.      INABILITY OF CORPORATION TO PURCHASE SHARES

         If the  Corporation  does not have  sufficient  surplus  to  permit  it
lawfully  to  purchase  all of the  Shares as it deems  desirable  hereunder  to
purchase,  the  Shareholders  shall  promptly  take such  measures to vote their
respective  holdings  of Shares to reduce  the  capital of the  Corporation,  to
revalue the capital of the Corporation so as to increase its surplus, or to take
such  other  steps as may be  appropriate  or  necessary  in order to enable the
Corporation lawfully to perform its obligations hereunder,  including, by way of
illustration and not by way of limitation, an up-to-date appraisal of the assets
of the Corporation.

         15.      NONIMPAIRMENT

         In no event shall the  purchase  of a  Shareholder's  Shares  cause the
Corporation's solvency and continuing operations to be impaired. Accordingly, in
the event  insurance  proceeds  (if  obtained  for death of a  Shareholder)  are
insufficient   to  discharge   the   Corporation's   obligation  to  purchase  a
Shareholder's  Shares,  then,   notwithstanding  any  other  provision  of  this
Agreement, the payment of the purchase price of the Shares shall be accomplished
so as not to cause the solvency and continued  operations to be impaired on such
terms  and  conditions  as  the  directors  of the  Corporation  in  good  faith
determine.

                                       13

<PAGE>

         16.      STATUS OF TRANSFEREES

          Except with respect to donees of a Shareholder as set forth in section
3 hereof,  any person or entity acquiring any Share of stock in the Corporation,
by accepting it, shall be deemed to be a party to this Agreement and to agree to
be  subject to all the terms and  conditions  of this  Agreement  as if he or it
signed this  Agreement  as a  Shareholder.  Each such  transferee  shall sign an
agreement joining to this Agreement.

         17.      INDEBTEDNESS OF TRANSFEROR TO CORPORATION

         If the  transferor  of any Shares  sold  hereunder  is  indebted to the
Corporation  at the time the purchase  price for the Shares is to be paid by the
Corporation,  the purchase price paid for such Shares, including any interest or
any deferred payments of such purchase price, shall first be applied against the
outstanding balance of such indebtedness, and the balance of such purchase price
and  interest  shall be paid to the  transferor  of the  Shares  as  hereinabove
provided.

          18.     PURCHASE BY THE CORPORATION

         Whenever the Corporation, pursuant to this Agreement, purchases Shares,
all  Shareholders  shall do all things and execute and deliver all papers as may
be  necessary  to  consummate  such  purchase.  All Shares so  purchased  by the
Corporation shall be cancelled.

          19.     SPECIFIC PERFORMANCE

         The parties  hereby  declare that it is  impossible to measure in money
the  damages  that will  accrue to a part or to the  Shareholder  by reason of a
failure  of a party to perform  any of the  obligations  under  this  Agreement.
Therefore, if the Corporation, any Shareholder, the personal representative of a
Decedent or the trustee(s) of a Dissolved Shareholder shall institute any action
or proceeding to  specifically  enforce the provisions  hereof,  then any person
(including  the  Corporation)  against whom such action or proceeding is brought
hereby  waives the claim or  defense  therein  that such  party has an  adequate
remedy at law, and such person  shall not urge in any such action or  proceeding
the claim or defense  that an adequate  remedy at law exists so as to defeat the
claim for specific performance of this Agreement.

          20.      NOTICES

         Any and all notices,  designations,  consents, offers,  acceptances, or
any other  communication  provided  for herein  shall be given in writing  which
shall  be  addressed  to the  Shareholders  at the  current  address  which  the
Shareholders  have  furnished  to the  Corporation  and  which is on file at the
Corporation's office and to

                                       14

<PAGE>

the Corporation at its principal  office,  or if none, to the last known address
of the addressee,  and shall be deemed given (i) when actually  received by hand
delivery  or express  courier,  or (ii) five (5) days  after  posting by postage
pre-paid certified or registered mail.

          21.      GOVERNING LAW

         This Agreement shall be governed, construed,  interpreted, and enforced
in accordance with the laws of the State of Delaware.

         22.      ARBITRATION/ATTORNEY FEES

         The parties  will attempt in good faith to resolve any  controversy  or
claim  arising out of or relating to this  Agreement by mediation in  accordance
with the Center for Public  Resources  Model Procedure for Mediation of Business
Disputes.

         If the matter has not been resolved pursuant to the aforesaid mediation
procedure  within sixty days of the commencement of such procedure (which period
may be  extend  by  mutual  agreement),  the  controversy  shall be  settled  by
arbitration  in  accordance  with the  Center  for  Public  Resources  Rules for
Non-Administered Arbitration of Business Disputes, by three arbitrators, of whom
each party shall  appoint one. The  arbitration  shall be governed by the United
States  Arbitration Act, 9 U.S.C. ss. 1-16, and judgment upon the award rendered
by the  Arbitrator(s) may be entered by any court having  jurisdiction  thereof.
The place of arbitration shall be Orlando, Florida.

         The prevailing party in such arbitration  shall be entitled to an award
of attorney's fees incurred during the mediation and arbitration.

         23.      BINDING EFFECT

         This  Agreement  will inure to the  benefit of and be binding  upon the
Corporation,  its  successors  and assigns,  including,  but not limited to, any
Corporation  or  entity  that  may  acquire  all  or  substantially  all  of the
Corporation's  assets  and  business  or  into  which  the  Corporation  may  be
consolidated or merged,  and upon the Shareholders,  their successors,  assigns,
heirs,  and legal  representatives,  as the case may be,  and shall bind all who
sign regardless of whether one or more persons who hold Shares fail to sign this
Agreement.

         24.      MULTIPLE COPIES OR COUNTERPARTS OF AGREEMENT.

         The original and one or more copies of this  Agreement  may be executed
  by one or more of the  parties.  In such event,  all of such  executed  copies
  shall have the same force and effect as the executed original, and all of such
  counterparts,  taken  together,  shall  have the  effect  of a fully  executed
  original.

                                       15

<PAGE>

         25.      NO ASSIGNMENT

         This Agreement and a Shareholder's rights hereunder may not be assigned
by a Shareholder to any firm,  entity,  or person  without the express,  written
approval of the Corporation and the other Shareholders.

         26.      INVALID PROVISION

         The invalidity or  unenforceability  of a particular  provision of this
Agreement shall not affect the other provisions  hereof, and the agreement shall
be construed in all respects as if the invalid or unenforceable  provisions were
omitted.

         27.      ENTIRE AGREEMENT

         This Agreement  constitutes the entire  agreement and  understanding of
the parties with respect to the  transfer of the Shares and  supersedes  any and
all prior agreements regarding the Shares, whether written or oral.

         28.      SURVIVAL

                  All sections of this Agreement  shall survive the  termination
of this  Agreement  for any reason as are  necessary to effect the rights of the
parties hereto or of any Trustee appointed hereunder.

         IN WITNESS  WHEREOF,  the  Corporation  and QVESTOR have  executed this
instrument  by  and  through  their  authorized   officers  and  the  individual
Shareholders  have  hereunto  placed their hands on the day and year first above
written.


                                        "CORPORATION":

Witnesses:                              IXION BIOTECHNOLOGY, INC.

              /S/                                       /S/
--------------------------------        By:---------------------------------
Thomas P. Stagnaro                      Weaver Gaines
                                        Chairman and Chief Executive Officer





                                       16
<PAGE>



                                        "Q-MED":

Witnesses:                              Q-MED AB (publ)

               /S/                                         /S/
--------------------------------        By:----------------------------------
 Terence F. Brennan                     Per Olof Wallstrom
                                        President and Chief Executive Officer


              /S/                                          /S/
--------------------------------        By:----------------------------------
 Terence F. Brennan                     Bengt Agerup
--------------------------------        Member of the Board of Directors











                                       17
<PAGE>



                                       "QVESTOR":

Witnesses:                             QVESTOR LLC



              /S/                                      /S/
--------------------------------       By:------------------------------------
Terence F. Brennan                          Per Olof Wallstrom







                                       18
<PAGE>




Witnesses:                              AMMON B. PECK PH.D

               /S/                                      /S/
-------------------------------         ----------------------------------
Theodore Lee Snow                       Ammon B. Peck, Individually

               /S/
-------------------------------
Kimberly A. Ramsey


Witnesses:                              WEAVER H. GAINES

              /S/                                       /S/
-------------------------------         ----------------------------------
Thomas P. Stagnaro                      Weaver H. Gaines, Individually






                                       19
<PAGE>





                                   SCHEDULE A
                                   ----------

                                  Agreed Value
                                  ------------


The Agreed Value for the Shares as of July -----, 2000 is $4.00 per share.

                                           the "CORPORATION":

Witnesses:                                 IXION BIOTECHNOLOGY, INC.


--------------------------------           By:------------------------------
                                           Weaver Gaines
--------------------------------           Chairman and Chief Executive Officer


"Q-MED":

Witnesses:                                 Q-MED AB (publ)



--------------------------------           By:------------------------------
                                           Per Olof Wallstrom
--------------------------------           President and Chief Executive Officer



--------------------------------           By:------------------------------
                                           Bengt Agerup
--------------------------------           Member of the Board of Directors


                                           "QVESTOR":

Witnesses:                                 QVESTOR LLC



--------------------------------           By:------------------------------
                                           Per Olof Wallstrom
--------------------------------


                                       20
<PAGE>




Witnesses:                                 AMMON B. PECK PH.D



-------------------------------            ----------------------------------
                                           Ammon B. Peck, Individually
-------------------------------



Witnesses:                                 WEAVER H. GAINES



-------------------------------            ----------------------------------
                                           Weaver H. Gaines, Individually
-------------------------------


                                       21
<PAGE>

                                   EXHIBIT 1
                                   ---------


                             VOTING TRUST AGREEMENT


     This is a Voting Trust Agreement (the "Agreement") dated as of
----------------, among IXION Biotechnology Inc. ("Company"), -----------------
("Shareholder") and QVESTOR, LLC, a Delaware limited liability company, as
Trustee.

                                   Background

     The Shareholder currently owns ---------- shares of common stock (the
"Shares") of IXION BIOTECHNOLOGY, INC. (the "Company"). Pursuant to section 4(d)
of a Shareholders' Agreement dated July 14, 2000 among the Shareholder, the
Company, and certain other shareholders named therein ("Shareholders
Agreement"), the parties desire to enter into this Agreement regarding the
deposit of the Shares with the Trustee. Accordingly, in consideration of the
mutual covenants and agreements set forth below, the parties agree as follows:

                                      Terms

         1. Filing. A copy of this Agreement and any amendment to this Agreement
shall be filed in the principal office of the Company, and shall be open to the
inspection of any shareholder of the Company. All voting trust certificates (the
"Certificates") issued pursuant to this Agreement shall be issued, received, and
held subject to all the terms of this Agreement. Every person entitled to
receive voting trust certificates under this Agreement, representing shares of
common stock of the Company, and their permitted transferees and assigns, shall
be bound by the provisions of this Agreement.

         2. Appointment of the Trustee. The Trustee shall be QVESTOR, LLC.

         3. Transfer of Stock to Trustee. As soon as reasonably possible after
the execution of this Agreement, the Shareholder will deposit with the Trustee,
the certificate or certificates for the Shares, together with instruments duly
executed for the transfer of the Shares to the Trustee. Pending the delivery of
such instruments, the Shareholder hereby transfers the Shares to the Trustee.
The Shares shall be vested in the Trustee and shall be transferred to the name
of the Trustee on the books of the Company.

         4. Trust Certificates. Following the deposit by the Shareholder of the
certificate or certificates representing their respective Shares with the
Trustee, the Trustee shall issue and deliver a Certificate to the Shareholder
representing his

<PAGE>

beneficial ownership of the Shares (a "Certificate"),  in substantially the form
attached to this Agreement as Exhibit A.

         5.       Rights of Trustee.

                  (a) The Trustee shall have the right to exercise, in person or
by proxy, all of the Shareholder's voting rights and powers in respect of the
Shares registered in the name of the Trustee, and to take part in or consent to
any and all corporate or shareholder action. The right to vote shall include,
without limitation, the right to vote on the election ofdirectors. The Trustee
may in all  matters act either at a meeting or by written  consent.  The parties
acknowledge that the Trustee, for purposes of this Agreement, shall be permitted
to vote the Shares and to exercise  all such powers as are  necessary  for every
legitimate business purpose for the Company. The Trustee shall have no liability
for any actions taken pursuant to this Agreement, except for those actions taken
in bad faith or in willful violation of this Agreement.

                  (b) It is expressly understood and agreed that the Shareholder
or any future holders of Certificates (the "Holders") shall not have any right
with respect to any Shares held by the Trustee to vote, to take part in, to
consent to or in any way control or limit any corporate or shareholders' action.

                  (c) In voting the Shares held pursuant to this Agreement
(either in person or by Proxy), the Trustee shall exercise its reasonable
business judgment and may take such part in the management of the Company's
affairs as it deems appropriate.

                  (d) It is expressly understood and agreed that at any time,
subject to compliance with: (i) all applicable federal and state securities
laws, (ii) all applicable shareholder agreements and (iii) any underwriter
lock-up agreements that a Holder may sell, assign or otherwise transfer any of
the Certificates and may pledge or otherwise encumber the Certificates;
provided, however, the Shares represented by such Certificates shall continue to
be bound by this Agreement and the new Holder shall sign a copy of this
Agreement.

                  (e) The Trustee shall have the right, in its sole discretion
and at any time during the term of this Agreement, to permit any Holder to sell,
assign or otherwise transfer all or any portion of the Shares represented by the
Holder's Certificates free of this Agreement, and this Agreement will continue
in full force and effect with respect to all remaining Shares.

                  (f) It is also expressly understood and agreed that the
Trustee has no rights in the Shares other than the voting rights set forth in
this Agreement. All of the economic benefits of ownership of the Shares remain
vested in the Shareholders. The Trustee may not at any time sell, transfer,
assign, pledge or otherwise encumber any of the Shares without the consent of
the relevant Holders.

                                       2

<PAGE>

         6. Term. This Agreement shall continue in effect for a period extending
until the earlier of (a) July 15, 2010 or (b) the date that the Trustee and
Shareholder agree in writing to terminate this Agreement.

         7.       Termination Procedure.

                  (a) Upon the termination of this Agreement, the Trustee shall
mail written notice of such termination to the registered owners of the
Certificates, at the addresses appearing on the transfer books of the Trustee.
After the date of any such notice, the Certificates shall cease to have any
effect, and the Holders of the Certificates shall have no further rights under
this Agreement other than to receive certificates for shares of stock of the
Company or other property distributable under the terms of this Agreement and
upon the surrender of the Certificates.

                  (b) Promptly following the termination of this Agreement and
the surrender to the Trustee of the Certificates, the Trustee shall take all
actions necessary to have the record ownership of that number of Shares
represented by the Certificates transferred on the books of the Company into the
name of the Holder or the Holder's nominees and shall have the Certificates
representing such Shares delivered to such Holder or the Holder's nominee. The
Trustee shall deliver to each registered Holder, stock certificates for the
number of Shares represented by the Certificate held by such Holder, upon the
surrender of the properly endorsed Certificate.

         8.       Dividends.

                  (a) Prior to the termination of this Agreement the Holders
shall be entitled to receive payments of cash dividends, if any, paid by the
Company upon a like number and class of shares of Common Stock as is represented
by each Certificate. If any dividend or distribution in respect of the Shares
deposited with the Trustee is paid, in whole or in part, in stock of the Company
having general voting powers, the Trustee shall receive and hold, subject to the
terms of this Agreement, the certificates for stock which are distributed on
account of such dividend or distribution and the Holder shall be entitled to
receive a Certificate issued under this Agreement for the number of shares and
class of stock received as such dividend or distribution with respect to the
Shares represented by such Certificate. The Trustee shall have no interest in
such dividend Shares, other than the right to exercise voting rights.

                  (b) If any dividend or distribution in respect of the stock
deposited with the Trustee is paid other than in cash or in capital stock having
general voting powers, then the Trustee shall distribute such dividend or
distribution to the Holders registered as such at the close of business on the
day fixed by the Trustee for taking a record to determine the Holders entitled
to receive such distribution.

                                       3

<PAGE>

Such distribution shall be made to such Holders ratably,  in accordance with the
number of Shares represented by their respective Certificates.

                  (c) The Trustee shall instruct the Company, in writing, to pay
all cash dividends directly to the Holders or their legal representatives.

                  (d) The Company is authorized to report or direct the
reporting of such dividends to federal or state taxing authorities, as required
by law, using the respective taxpayer identification number of each Holder. Each
Holder agrees to provide the Company with such additional information as is
requested by the Company for such purpose.

         9. Dissolution of the Company. In the event of the dissolution or total
or partial liquidation of the Company, whether voluntary or involuntary, to the
extent that any distributions are received by the Trustee, the Trustee shall
distribute any securities, rights, or property, to which the Holders are
entitled, among the registered Holders or their legal representatives in
proportion to their interests, as shown by the books of the Trustee.

         10. Reorganization of Company. In case the Company is merged into or
consolidated with another corporation, or entity, or all or substantially all of
the assets of the Company are transferred to another corporation or entity, then
in connection with such transfer, the term "Company" for all purposes of this
Agreement shall be taken to include such successor corporation or entity, and
the Trustee shall receive and hold as Trustee under this  Agreement any stock of
such successor  corporation  received on account of the ownership,  of the stock
held under this Agreement, prior to such merger, consolidation, or transfer.

         11.      Trustee.

                  (a) The Trustee (and any successor Trustee) may at any time
resign by mailing to the registered Holders a written resignation, to take
effect thirty days thereafter or upon the prior acceptance of the duties of
Trustee by a successor Trustee.

                  (b) The rights, powers, and privileges of the Trustee named
under this Agreement shall be possessed by any successor Trustee, with the same
effect as though such successors had originally been parties to this Agreement.
The word "Trustee" as used in this Agreement, means the Trustee or any successor
Trustee acting under this Agreement.

         12. Notices. To be effective, a notice or other communication required
or permitted by this Agreement must be in writing. All notices and other
communications shall be delivered by overnight courier service or hand delivery.
Communications shall be addressed to the intended recipient at the address

                                       4

<PAGE>

specified below, or to such other address as the intended recipient may have
designated in a writing previously delivered to the sender:

If to the Company:                         If to the Trustee:

IXION BIOTECHNOLOGY, INC.                  QVESTOR
13704 Progress Boulevard, Box 13           c/o The Corporation Trust Company
Alachua, Florida 32615                     1209 Orange Street
                                           Wilmington, DE

                                           With a copy to:

                                           Terence F. Brennan, Esq.
                                           Holland & Knight LLC
                                           P.O. Box 1526
                                           Orlando, FL  32802

If to the Shareholder:


------------------------------
------------------------------
------------------------------

         13. Governing Law and Venue. This Agreement shall be governed by and
construed under the laws of Delaware. Any suit brought to enforce or construe
any provision of this Agreement shall be brought only in the appropriate court
located in Orange County, Florida; provided, however, the Trustee may initiate
an action in any jurisdiction having jurisdiction over the parties to enjoin a
violation of this Agreement.

         14. Entire Agreement. This Agreement, including its exhibits,
constitutes the entire agreement of the parties concerning its subject matter
and supersedes any prior or contemporaneous agreements or understandings among
them, concerning its subject matter.

         15. Amendment. Upon the written consent of the Trustee and Shareholder
any provisions of this Agreement may be amended.

         16. Voting Power. For the purposes of this Agreement, "Voting Power"
related to Shares shall mean the underlying voting power of the Shares.

         17. Counterparts. This agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
shall constitute one and the same instrument.

                                       5

<PAGE>

         IN WITNESS WHEREOF, the parties have executed this Voting Trust
Agreement as of the date first written above.



Date:-------------------------     ------------------------------
                                   Shareholder




                                   QVESTOR, LLC ("Trustee")


Date:-------------------------     By:---------------------------


                                   IXION BIOTECHNOLOGY, INC. ("Company")
                                   13704 Progress Boulevard, Box 13
                                   Alachua, Florida 32615


Date:-------------------------     By:----------------------------




                                        6

<PAGE>


                            EXHIBIT A (to Exhibit 1)
                            ------------------------


                                Trust Certificate
                                -----------------

No. ------                                       --------------- Shares of Stock

         QVESTOR, LLC, the Trustee of the shares deposited under a Voting Trust
Agreement effective ------------------, having received certain shares of IXION
BIOTECHNOLOGY, INC., a Delaware corporation (the "Company"), pursuant to such
Agreement, hereby certifies that ----------------- will be entitled to receive a
certificate for --------------- fully paid --------------- shares of the Company
on the expiration of the Voting Trust Agreement, and in the meantime shall be
entitled to receive payments equal to any dividends that may be collected by the
Trustee upon a like number of such shares held by him under the terms of the
Voting Trust Agreement.

         Neither this certificate, nor the shares of capital stock for which it
is issued, have been registered under the Securities Act of 1933, as amended, or
any applicable state securities laws, and no transfer or assignment of this
certificate or the shares for which it is issued may be made in the absence of
an effective registration statement under such laws or the availability of
exemptions from the registration provisions thereof in respect of such transfer
or assignment.

         This certificate is subject to restrictions on transfer contained in
the Voting Trust Agreement dated as of -------------------, and the Shareholders
Agreement dated July 14, 2000 among the Company, the Shareholder, and certain
other shareholders named therein, including without limitation, all conditions,
rights of first refusal, options, or other restrictions on transfer of the
shares and is transferable only on the books of the undersigned Trustee by the
registered holder in person or by his duly authorized attorney, and the holder
hereof consents that the undersigned Trustee may treat the registered holder
hereof as the trust owner for all purposes, except the delivery of share
certificates, which delivery shall not be made without the surrender hereof.

         IN WITNESS WHEREOF, the undersigned have executed this Voting Trust
Certificate as of this --------- day of -----------------------.


                                  QVESTOR, LLC



                                  By:--------------------------




                                       7

<PAGE>



                                   EXHIBIT 5.6
                                   -----------

                             Certificate of Company


                                  See attached.


<PAGE>


                                   EXHIBIT 5.7
                                   -----------

       Written Opinion of Company's Counsel (Brashear & Associates, P.L.)



                                 July 14, 2000




Qvester, LLC



Gentlemen:

         We refer to the Stock  Purchase  Agreement,  dated as of July 14,  2000
(the  "Purchase  Agreement"),  between  Ixion  Biotechnology,  Inc.,  a Delaware
corporation  (the  "Company")  and  Qvester  LLC, a Delaware  limited  liability
company (the "Purchaser").  We render this opinion pursuant to subsection 5.7 of
the Purchase Agreement as counsel to the Company. Capitalized terms used but not
defined herein have the meanings given them in the Purchase Agreement.

I.       Documents Reviewed

         In preparing this opinion we have reviewed the following documents:
         A.       The Purchase Agreement;

         B.       The  Shareholders'  Agreement  dated July 14, 2000 among the
                  Company,  the Purchaser,  Ammon B. Peck Ph.D, Weaver H. Gaines
                  and David C. Peck (the "Shareholders' Agreement");

         C.       The  Employment  Agreement  dated July 14, 2000 between the
                  Company and Weaver H. Gaines (the  "Employment Agreement");

         D.       Voting  Trust  Agreement  dated  July 14,  2000,  between  the
                  Company and the Purchaser (the "Voting Trust Agreement");

         E.       David C. Peck  Director's  Agreement  dated July 14,  2000
                  (the  "Director's Agreement");

         F.       Agreements and Releases dated as of July 14, 2000,  between
                  the Company and Weaver H. Gaines,  Theodore L. Snow,  David C.
                  Peck and Ammon B. Peck,  respectively  (collectively,  the
                  "Agreement  and Release").

         (Note:  The  above-referenced   Shareholders'   Agreement,   Employment
Agreement , Voting Trust  Agreement,  Director's  Agreement,  and  Agreement and
Release shall hereinafter be referred to collectively as the "Documents.")

         G.       The form of stock  certificates  of the  Company's  Common
                  Stock to be issued  pursuant  to the  Purchase Agreement;

         H.       The minute books, stock books and stock transfer ledgers of
                  the Company.
<PAGE>
         In addition,  we have  examined such  records,  certificates  and other
documents of the Company as we have deemed necessary, relevant or appropriate to
enable us to render the opinions  expressed  below. We have, when relevant facts
were not independently established, relied upon representations and certificates
of the officers of the Company. In addition,  having no independent knowledge of
contrary facts, we have also obtained at our request,  examined and relied upon,
certificates  of public  officials and  certificates,  affidavits,  opinions and
written  representations of the officers of the Company and such other corporate
records,  documents,  orders,  certificates  and  other  instruments  as in  our
judgment  are  necessary  or  appropriate  to enable us to render  the  opinions
expressed   below.   Except  as  expressed   below,  we  have  made  no  special
investigation  or review of any judgments,  decrees,  franchises,  certificates,
permits or the like, and have made no  independent  search of the records of any
judicial authority or governmental agency.

II.      Qualifications, Exceptions, Assumptions and Limitations.

         The  opinions  expressed  in  Section  III  herein  are  subject to the
following qualifications, exceptions, assumptions and limitations:

A. We express no opinion as to the laws of any jurisdiction other than the State
of Delaware,  the State of Florida and the federal laws of the United  States of
America.

B.  We  have  assumed:  (i)  the  genuineness  of  all  signatures  on  and  the
authenticity of all documents  examined by us and the conformity to originals of
all documents  submitted as certified or photostatic  copies thereof;  (ii) that
all documents  and  agreements to which the Company is a party will be construed
in  accordance  with the  internal  laws of the  jurisdictions  specified by the
parties therein; (iii) that no fraud or dishonesty exists with respect to any of
the matters relevant to our opinions; and (iv) the legal capacity of all natural
persons.

C. This opinion is further subject to the qualifications that the enforceability
of the Articles,  the Purchase Agreement and the Documents may be limited by and
subject to (i) applicable  bankruptcy,  insolvency,  reorganization,  fraudulent
transfer or conveyance,  moratorium or other similar laws  affecting  creditors'
rights;   (ii)  general   principles  of  equity  (regardless  of  whether  such
enforceability  is considered  in a proceeding in equity or at law),  commercial
reasonableness and  conscionability;  and (iii) the power of the courts to award
damages in lieu of equitable remedies.

D. We have assumed,  with respect to the Purchaser:  (i) the due  authorization,
execution and delivery by such  Purchaser of all documents  and  instruments  to
which  it  is  a  party;  (ii)  the  legality,   binding  effect,  validity  and
enforceability  as to  or  as  against  such  Purchaser  of  all  documents  and
instruments to which it is a party or by which it is bound; (iii) the absence of
any requirement of consent,  approval or  authorization  by any person or by any
governmental   authorities  with  respect  to  such  Purchaser;   and  (iv)  the
organization,  existence  and good  standing  of the  Purchaser  and  that  such
Purchaser has all necessary power and authority to execute,  deliver and perform
the Documents to which it is a party.

E. We have assumed that the  Purchaser's  principal  place of business is in the
State of Delaware.

                                     Page 2
<PAGE>
F. We have  assumed:  (i) the due  authorization,  execution and delivery by all
parties  other than the Company of the Purchase  Agreement and the Documents and
of all agreements  and documents  which are to be executed and delivered by such
other parties pursuant  thereto;  (ii) the accuracy of the  representations  and
warranties  made by the  Company  as to matters  of fact in or  pursuant  to the
Purchase Agreement and the Documents;  and (iii) that the Purchase Agreement and
the Documents are valid, binding and enforceable  obligations of all the parties
thereto (other than the Company).

G. We have further assumed those matters described in Section II.K of the Report
on Standards for Florida  Opinions  dated April 8, 1991,  issued by the Business
Law  Section of the  Florida  Bar (the  "Report"),  a copy of which is  attached
hereto, is incorporated by reference into this opinion.

III.     Opinions

Based upon and relying on the assumptions  and limitations set forth herein,  it
is our opinion that:

A. The Company is duly incorporated and is validly existing and in good standing
under the laws of the State of Delaware.

B. The Company is duly qualified as a foreign  corporation to transact  business
in the state of Florida,  and is in good standing in every jurisdiction in which
the  failure to so  qualify  might  reasonably  be  expected  to have a material
adverse  effect upon the business  prospects,  financial  condition or operating
results of the Company.

C. The Company  has all  necessary  corporate  power and  authority  to execute,
deliver  and perform  the  Purchase  Agreement  and the  Documents  to which the
Company is a party,  and to own its  property and to conduct its business in the
manner in which such business is currently being conducted.

D. The Purchase Agreement and the Documents to which the Company is a party have
been duly  authorized,  executed and  delivered  by the  Company,  and each such
agreement is a valid and binding obligation of the Company,  enforceable against
the Company in accordance with their terms.

E. In accordance  with subsection 2.2 of the Purchase  Agreement,  the Company's
Certificate of  Incorporation  authorizes  the issuance of 20,000,000  shares of
common stock and 1,000,000 shares of Preferred Stock.

F.  In  accordance  with  subsection  5.8(b)  of  the  Purchase  Agreement,  the
employment agreement dated August 31, 1994 between David C. Peck and the Company
and the  consulting  agreement  dated July 1, 1996 between David C. Peck and the
Company have been terminated and pursuant to such termination, David C. Peck has
released  the  Company,  the  Purchaser  and  Q-Med  AB from all  liability  and
obligations  whatsoever  arising  under  the  aforementioned  agreements  or the
termination thereof,  other than those obligations  recognized in the Director's
Agreement.

G. In accordance with subsection 5.10 of the Purchase Agreement, the Company has
terminated  the  following  deferred  compensation  plans  and all  modification
amendments and renewals  thereof:  (i) the Deferred  Compensation Plan Agreement
with David C. Peck dated  April 1, 1994;  (ii) the  Deferred  Compensation  Plan
Agreement with Ammon B. Peck dated June 1,

                                     Page 3
<PAGE>

1994; (iii) the Deferred Compensation Plan Agreement with Weaver H. Gaines dated
January 1, 1994; and (iv) the Deferred Compensation Plan Agreement with Theodore
L. Snow dated January 3, 1994.  Moreover,  the Company has obtained  releases in
favor of the  Company,  the  Purchaser  and  Q-Med  AB from  the  aforementioned
individuals  releasing  the  Company,  the  Purchaser  and  Q-Med  AB  from  all
obligations and liabilities whatsoever arising under the aforementioned plans or
the termination thereof. In addition,  all deferred compensation amounts arising
pursuant to the  aforementioned  plans have been  converted  into Company Common
Stock at the rate of Four Dollars ($4.00) per share.

H. In accordance with subsection 5.9 of the Purchase  Agreement,  any landlord's
consents that may be required under the Real Property leases with respect to the
properties  leased by the  Company to permit  such leases to remain in effect on
their current terms and  conditions  following the Closing have been obtained by
the Company.

I. The Common  Stock  issuable  at the  Closing  have been duly  authorized  and
reserved  for  issuance  by the  Company,  there  are no  statutory  or,  to our
knowledge,  contractual or preemptive rights of stockholders with respect to the
issuance of such Common  Stock,  and such Common Stock shall be validly  issued,
fully paid and nonassessable.

J. The  execution  and  delivery by the Company of the Purchase  Agreement,  the
Documents and the other agreements  contemplated in the Purchase Agreement,  the
issuance of the Common Stock to the Purchaser upon Closing,  do not and will not
(a) conflict  with or result in a breach of the terms,  conditions or provisions
of, (b)  constitute  a default  under,  (c) result in the  creation of any lien,
mortgage,  security  interest,  charge or other  encumbrance  upon the Company's
capital  stock or assets  pursuant  to,  (d) give any  third  party the right to
accelerate  any obligation  under,  (e) result in a violation of, or (f) require
any authorization,  consent, approval, exemption or other action by or notice to
any court or administrative or governmental body pursuant to, the Articles,  the
Company's Bylaws,  or, to the best of our knowledge,  any law, statute,  rule or
regulation to which the Company is subject, or any agreement, instrument, order,
judgment or decree to which the Company is subject and which is known to us.

K. As of the Closing Date and giving effect to the  transaction  contemplated in
this Agreement,  the authorized  capital stock of the Company consists solely of
twenty million  (20,000,000)  shares of Common Stock, of which 6,773,653  common
shares are issued and  outstanding,  268,400 common shares (less shares reserved
for  Purchaser  prior to Closing) are reserved  for  issuance  upon  exercise of
options granted,  and 48,185 common shares (including warrants to purchase 3,042
common shares claimed by The University of Florida  Research  Foundation,  Inc.)
are reserved for issuance upon exercise of outstanding  warrants.  Except as set
forth in Schedule 2.2 of the Purchase  Agreement,  there are no  outstanding  or
authorized  options,  warrants,  calls,  subscriptions,  rights  (including  any
preemptive rights or rights of first refusal),  agreements or commitments of any
character  obligating the Company to issue any shares of its capital stock.  All
issued  and  outstanding   shares  of  the  Company's  capital  stock  are  duly
authorized,  validly issued, fully paid and nonassessable and free of preemptive
rights.

L. To the best of our knowledge, there are no (a) outstanding shares of stock or
securities  convertible  into or  exchangeable  or exercisable for shares of the
Company's  capital  stock,  (b) other than as set forth in  Schedule  2.2 of the
Purchase  Agreement,  outstanding options for the purchase of, or any agreements
providing for the issuance  (contingent  or  otherwise)  of, or  commitments  or
claims of any  character  relating to, any such  capital  stock or any shares of
stock or securities convertible into or exchangeable or exercisable for any such
capital stock.

                                     Page 4
<PAGE>

M. To the best of our  knowledge,  based on  information  provided  to us by the
Company:  (i)  there  have been no  material  change  in the  business,  assets,
properties,  operations,  financial status or prospects of the Company since the
Balance  Sheet  Date;  (ii) there is no material  action,  suit,  proceeding  or
investigation  against the  Company  which is pending or  threatened  before any
court, arbitrator or governmental agency or authority;  (iii) the Company is not
in violation of or in default under the Articles or any judgments,  injunctions,
orders or decrees  binding  upon it; and (iv) there is no claim that the Company
is not in material violation or default of or under its bylaws or the agreements
required to be listed in Schedule 2.15 to the Purchase Agreement.

The qualification of any opinion or statement herein by the use of the words "to
the best of" or words of similar  import (unless  otherwise  stated) means that,
during the course of our representation of the Company,  no information has come
to our  attention  which  gives us actual  knowledge  of the  existence  of such
matters,  documents or facts, and no inference as to our knowledge thereof shall
be drawn from the fact of our  representation of any party or otherwise.  Except
as  expressly  set  forth  herein,   we  have  not  undertaken  any  independent
investigation  to determine the existence or absence of such facts (and have not
caused to be made any review of any court file or indices)  and no  inference as
to our knowledge  concerning  such facts should be drawn from the fact that such
representation has been undertaken by us.

This opinion is as of the date hereof,  and we undertake no, and hereby disclaim
any,  obligation  to advise you of any  change in any  matter  set forth  herein
occurring after the date hereof. Without our prior written consent, this opinion
may not be relied upon by anyone other than you and your legal counsel or quoted
in whole or in part or otherwise referred to in any report or document furnished
to any person or entity.

                                               Sincerely,

                                               BRASHEAR & ASSOCIATES, P.L.


                                                            /S/
                                               By:--------------------------
                                               Bruce Brashear, Esq.



                                     Page 5


<PAGE>
                                 EXHIBIT 5.8(a)
                                 --------------

               Employment Agreement between Company and W. Gaines





                                 See attached.


<PAGE>

                                 EXHIBIT 5.8(b)
                                 --------------

                       Director's Agreement of David Peck



                                  See attached.



<PAGE>


                                   EXHIBIT 6.5
                                   -----------

                            Certificate of Purchaser




                                  See attached.


<PAGE>

                                   EXHIBIT 6.6
                                   -----------


        Side Letter (Q-Med) and Amended and Restated Side Letter (Q-Med)




                                  See attached.





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