VION PHARMACEUTICALS INC
8-K, 2000-06-22
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549



                                    FORM 8-K


                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


Date of Report (Date of earliest event reported)      JUNE 22, 2000
                                                      -------------

                           VION PHARMACEUTICALS, INC.
                           --------------------------
             (Exact Name of Registrant as Specified in its Charter)


          Delaware                     0-26534                    13-3671221
          --------                     -------                    ----------
(State or Other Jurisdiction         (Commission                (IRS Employer
     of Incorporation)               File Number)            Identification No.)



     4 Science Park, New Haven, CT                                     06511
     -----------------------------                                     -----
(Address of Principal Executive Offices)                             (Zip Code)



Registrant's telephone number, including area code:       (203) 498-4210
                                                          --------------

                                 Not Applicable
                                 --------------
          (Former Name or Former Address, if Changed Since Last Report)
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<PAGE>

Item 5.  Other Events

         On June 22, 2000, Vion  Pharmaceuticals,  Inc. (the "Company") issued a
press release, filed herewith as Exhibit 99.1, relating to an interim evaluation
of a Phase III  randomized  trial of  Promycin(R)  (porfiromycin)  combined with
radiotherapy  versus radiotherapy alone in patients with non-resectable head and
neck cancer. The Company has been informed by its licensee, Boehringer Ingelheim
(BI),  Ingelheim,  Germany,  that  the  interim  evaluation  did  not  meet  the
pre-determined criteria which would warrant continuation of accrual.


Item 7.  Financial Statements, Pro Forma Financial Information and Exhibits.

         (a) Not applicable.

         (b) Not applicable.

         (c)  Exhibits.

                  99.1     Press release issued June 22, 2000.





<PAGE>

                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.



                                      VION PHARMACEUTICALS, INC.



Date: June 22, 2000           By: /s/ Alan Kessman
                                  -----------------------------------------
                                  Name: Alan Kessman
                                  Title: President and Chief Executive Officer



<PAGE>

EXHIBIT INDEX
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                  99.1     Press release issued June 22, 2000.







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