VION PHARMACEUTICALS INC
424B3, 2000-08-17
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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         PROSPECTUS SUPPLEMENT FILED PURSUANT TO RULE 424(B)(3) AND (C)
          (TO PROSPECTUS DATED OCTOBER 22, 1998) FILE NUMBER 333-61477

                           VION PHARMACEUTICALS, INC.
                        2,950,152 SHARES OF COMMON STOCK
                       280,501 REDEEMABLE CLASS A WARRANTS
                       561,602 REDEEMABLE CLASS B WARRANTS

This Prospectus Supplement supplements the Prospectus dated October 22, 1998
relating to:
2,950,152 shares of common stock
280,501 redeemable Class A Warrants
561,602 redeemable Class B Warrants

The securities are being offered for the account of the selling securityholders.
The common stock listed below is underlying unit purchase options initially
acquired from Vion by D.H. Blair & Co. Inc. in August 1995 in connection with
our initial public offering. This Prospectus Supplement is incorporated by
reference into the Prospectus, and all terms used herein shall have the meanings
assigned to them in the Prospectus. On August 16, 2000 closing price of a share
of our common stock on the Nasdaq National Market was $10.25. Our common stock
is traded under the symbol "VION." There is no public market for the warrants,
which expired on August 13, 2000.

The section entitled "Selling Securityholders" is hereby amended to add one
individual (as transferee of Esther Stahler, a previously listed Selling
Securityholder) to the following table and to amend Esther Stahler's common
stock holdings as follows:

NAME                                                    COMMON STOCK BEING SOLD
------------------------------------                    -----------------------
Esther Stahler (1)                                      148,444
Gitel Family Partnership (1)                            148,444
--------------------------------

(1)  Represents the aggregate amount of securities owned by the Selling
     Securityholder as of August 16, 2000 and prior to giving effect to the sale
     of the securities being offered hereby, except that Esther Stahler's
     children hold an aggregate of 31,542 additional shares of common stock
     which represents under 1% of the outstanding common stock. Esther Stahler
     is a general partner of Gitel Family Partnership and is deemed a beneficial
     holder of all shares held by that partnership and her children.

         SEE "RISK FACTORS" BEGINNING ON PAGE 3 OF THE ACCOMPANYING PROSPECTUS
FOR A DESCRIPTION OF CERTAIN FACTORS THAT SHOULD BE CONSIDERED BY PROSPECTIVE
INVESTORS.

NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR PASSED UPON THE
ADEQUACY OR ACCURACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.

           The date of this Prospectus Supplement is August 17, 2000.

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