CYTOCLONAL PHARMACEUTICS INC /DE
S-8, 1996-09-10
PHARMACEUTICAL PREPARATIONS
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   As filed with the Securities and Exchange Commission on September 10, 1996
                                                    Registration No. 33-________
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   ----------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                          Cytoclonal Pharmaceutics Inc.
- --------------------------------------------------------------------------------
             (Exact Name of Registrant as Specified in Its Charter)

                                    Delaware
- --------------------------------------------------------------------------------
         (State or Other Jurisdiction of Incorporation or Organization)

                                   75-2402409
- --------------------------------------------------------------------------------
                      (I.R.S. Employer Identification No.)

9000 Harry Hines Boulevard, Dallas, Texas                               75235
- --------------------------------------------------------------------------------
 (Address of Principal Executive Offices)                             (Zip Code)

                             1996 Stock Option Plan
- --------------------------------------------------------------------------------
                            (Full title of the Plan)

                             Arthur P. Bollon, Ph.D.
                       c/o Cytoclonal Pharmaceutics, Inc.
                           9000 Harry Hines Boulevard
                               Dallas, Texas 75235
- --------------------------------------------------------------------------------
                     (Name and Address of Agent For Service)

                                 (214) 353-2922
- --------------------------------------------------------------------------------
          (Telephone Number, Including Area Code, of Agent for Service)

                                    Copy to:
                              Robert H. Cohen, Esq.
                                 Bryan Cave LLP
                                 245 Park Avenue
                          New York, New York 10167-0034

                         CALCULATION OF REGISTRATION FEE
================================================================================
                            Proposed      Proposed
                             Maximum       Maximum
                             Amount       Offering      Aggregate    Amount of
   Title of Securities        to be       Price Per     Offering    Registration
    to be Registered       Registered       Share         Price         Fee
- ------------------------  ------------  ------------  ------------  ------------
Common Stock, $.01 par 
  value                      750,000      $3.875      $2,906,250    $1,002.15
================================================================================

(1) Estimated in accordance with Rule 457(h) solely for the purpose of
    calculating the registration fee. The price shown is the average of the high
    and low price of the Common Stock as reported on the National Association of
    Securities Dealers Automated Quotation System on September 6, 1996.

================================================================================
<PAGE>
                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference.
        ----------------------------------------

     The documents listed below are hereby incorporated by reference into this
Registration Statement, and all documents subsequently filed by Cytoclonal
Pharmaceutics Inc. (the "Registrant") pursuant to Sections 13(a), 13(c), 14 and
15(d) of the Securities Exchange Act of 1934, prior to the filing of a
post-effective amendment which indicates that all securities offered have been
sold or which deregisters all securities then remaining unsold, shall be deemed
to be incorporated by reference in this Registration Statement and to be a part
hereof from the date of filing such documents:

     (a) The Registrant's Annual Report on Form 10-KSB for the fiscal year ended
         December 31, 1995;

     (b) The Registrant's Quarterly Report on Form 10-QSB for the quarter ended
         March 31, 1996;

     (c) The Registrant's Quarterly Report on Form 10-QSB for the quarter ended
         June 30, 1996.

     (d) The Registrant's Registration Statement on Form 8-A, as filed with the
         Securities and Exchange Commission on May 17, 1995, to register the
         Common Stock, $.01 par value, under Section 12(g) of the Securities and
         Exchange Act of 1934, as amended, which Registration Statement contains
         a description of the Common Stock.

Item 4. Description of Securities.
        --------------------------

     No response is required to this item.

Item 5. Interests of Named Experts and Counsel.
        ---------------------------------------

     The legality of the securities offered hereby has been passed upon by Bryan
Cave LLP. Members of such firm are holders of equity securities of the
Registrant.

Item 6. Indemnification of Directors and Officers.
        ------------------------------------------

     Section 145 of the Delaware General Corporation Law grants each corporation
organized thereunder certain powers to indemnify its officers and directors
against liability for certain of their acts.

     ARTICLE EIGHTH of the Registrant's Certificate of Incorporation, as amended
provides as follows:

                                        2
<PAGE>

     The personal liability of a director to the Corporation or its stockholders
for monetary damages for breach of fiduciary duty as a director is hereby
eliminated, provided that this Article shall not eliminate or limit the
liability of a director (i) for any breach of the director's duty of loyalty to
the Corporation or its stockholders, (ii) for acts or omissions not in good
faith or which involve intentional misconduct or a knowing violation of law,
(iii) under Section 174 of the General Corporation Law of the State of Delaware,
or (iv) for any transaction from which the director derived an improper personal
benefit.

     ARTICLE NINTH of the Registrant's Certificate of Incorporation, as amended
provides as follows:

     The Corporation shall, to the fullest extent permitted by Section 145 of
the General Corporation Law of the State of Delaware, as the same may be amended
and supplemented, indemnify any and all persons whom it shall have power to
indemnify under said section from and against any and all of the expenses,
liabilities, or other matters referred to in or covered by said section, and the
indemnification provided for herein shall not be deemed exclusive of any other
rights to which those indemnified may be entitled under any By-Law, agreement,
vote of stockholders or disinterested directors, or otherwise both as to action
in his official capacity and as to action in another capacity while holding such
office, and shall continue as to a person who has ceased to be director,
officer, employee, or agent and shall inure to the benefit of the heirs,
executors, and administrators of such a person.

Item 7. Exemption From Registration Claimed.
        ------------------------------------

     No response to this Item is required.

Item 8. Exhibits.
        ---------

     4     1996 Stock Option Plan

     5     Opinion of Bryan Cave LLP, with respect to the legality of the Common
           Stock to be registered hereunder

     23(a) Consent of Richard A. Eisner & Company, LLP

     23(b) Consent of Bryan Cave LLP

Item 9. Undertakings
        ------------

     (a) The undersigned Registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
     a post-effective amendment to this Registration Statement to include any
     material information with respect to the plan of distribution not
     previously disclosed in the Registration Statement or any material change
     to such information in the Registration Statement;

                                        3
<PAGE>

         (2) That, for the purpose of determining any liability under the
     Securities Act of 1933 (the "Act"), each such post-effective amendment
     shall be deemed to be a new Registration Statement relating to the
     securities offered therein, and the offering of such securities at that
     time shall be deemed to be the initial bona fide offering thereof;

         (3) To remove from registration by means of a post-effective amendment
     any of the securities being registered which remain unsold at the
     termination of the offering.

     (b) Insofar as indemnification for liabilities arising under the Act may be
permitted to directors, officers and controlling persons of the Registrant as
described above, or otherwise, the Registrant has been advised that, in the
opinion of the Securities and Exchange Commission, such indemnification is
against public policy as expressed in the Act and is, therefore, unenforceable.
In the event that a claim for indemnification against such liabilities (other
than the payment by the Registrant of expenses incurred or paid by a director,
officer or controlling person of the Registrant in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the Registrant will,
unless in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the Act and
will be governed by the final adjudication of such issue.

                                        4
<PAGE>
                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Dallas, State of Texas, on the 6th day of September,
1996.


                                             Cytoclonal Pharmaceutics Inc.
                                       -----------------------------------------
                                                      (Registrant)

                                       By:/s/ Arthur P. Bollon, Ph.D.
                                          --------------------------------------
                                          Arthur P. Bollon, Ph.D.

     Pursuant to the requirements of the Securities Act of 1933, this
registration statement has been signed by the following persons in the
capacities and on the date indicated.

         Signature                       Capacity                    Date
- --------------------------  ---------------------------------  -----------------

/s/ Arthur P. Bollon
- --------------------------  Chairman, President, Chief         September 6, 1996
Arthur P. Bollon, Ph.D      Executive Officer and Director
                            (principal executive officer)

/s/ Ira Gelb
- --------------------------  Director                           September 6, 1996
Ira Gelb, M.D.

/s/ Irwin C. Gerson
- --------------------------  Director                           September 6, 1996
Irwin C. Gerson

/s/ Walter M. Lovenberg
- --------------------------  Director                           September 6, 1996
Walter M. Lovenberg, Ph.D.

/s/ Daniel Shusterman
- --------------------------  Vice President Operations,         September 6, 1996
Daniel Shusterman, J.D.     Treasurer and Chief Financial
                            Officer (principal financial
                            and accounting officer)

                                        5
<PAGE>
                                INDEX TO EXHIBITS
                          CYTOCLONAL PHARMACEUTICS INC.

Exhibit No.                               Description
- -----------  -------------------------------------------------------------------

4            1996 Stock Option Plan

5            Opinion of Bryan Cave LLP, with respect to the legality of the
             Common Stock to be registered hereunder

23(a)        Consent of Richard A. Eisner & Company, LLP

23(b)        Consent of Bryan Cave LLP (contained in Exhibit 5)

                                        6

                                                                       EXHIBIT 4

                          CYTOCLONAL PHARMACEUTICS INC.
                             1996 STOCK OPTION PLAN

1.     Purpose.

       The purpose of this plan (the "Plan") is to secure for Cytoclonal
Pharmaceutics Inc. (the "Company") and its shareholders the benefits arising
from capital stock ownership by employees, officers and directors of, and
consultants or advisors to, the Company and its subsidiary corporations who are
expected to contribute to the Company's future growth and success. Those
provisions of the Plan which make express reference to Section 422 shall apply
only to Incentive Stock Options (as that term is defined in the Plan).

2.     Type of Options and Administration.

       (a) Types of Options. Options granted pursuant to the Plan shall be
authorized by action of the Board of Directors of the Company or a committee
(the "Committee") designated by the Board of Directors and may be either
incentive stock options ("Incentive Stock Options") meeting the requirements of
Section 422 of the Internal Revenue Code of 1986, as amended or replaced from
time to time (the "Code") or non-statutory options which are not intended to
meet the requirements of Section 422 of the Code.

       (b) Administration. The Plan will be administered by the Board of
Directors of the Company or the Committee (references herein to the Board of
Directors shall be deemed to mean the Committee, if such a Committee has been so
designated), whose construction and interpretation of the terms and provisions
of the Plan shall be final and conclusive. The delegation of powers to the Board
of Directors shall be consistent with applicable laws or regulations (including,
without limitation, applicable state law and Rule 16b-3 promulgated under the
Securities Exchange Act of 1934 (the "Exchange Act"), or any successor rule
("Rule 16b-3")). The Board of Directors may in its sole discretion grant options
to purchase shares of the Company's Common Stock, $.01 par value per share
("Common Stock") and issue shares upon exercise of such options as provided in
the Plan. The Board of Directors shall have authority, subject to the express
provisions of the Plan, to construe the respective option agreements and the
Plan, to prescribe, amend and rescind rules and regulations relating to the
Plan, to determine the terms and provisions of the respective option agreements,
which need not be identical, and to make all other determinations in the
judgment of the Board of Directors necessary or desirable for the administration
of the Plan. The Board of Directors may correct any defect or supply any
omission or reconcile any inconsistency in the Plan or in any option agreement
in the manner and to the extent it shall deem expedient to carry the Plan into
effect and it shall be the sole and final judge of such expediency. No director
or person acting pursuant to authority delegated by the Board of Directors shall
be liable for any action or determination under the Plan made in good faith.
Subject to adjustment as provided in Section 15 below, the aggregate number of
shares of Common Stock that may be subject to options granted to any person in a
calendar year shall not exceed 20% of the maximum number of shares which may be
issued and sold under the Plan, as set forth in Section 4 hereof, as such
section may be amended from time to time.

                                        1
<PAGE>

       (c) Applicability of Rule 16b-3. Those provisions of the Plan which make
express reference to Rule 16b-3 shall apply to the Company only at such time as
the Company's Common Stock is registered under the Exchange Act, subject to the
last sentence of Section 3(b), and then only to such persons as are required to
file reports under Section 16(a) of the Exchange Act (a "Reporting Person").

3.     Eligibility.

       (a) General. Options may be granted to persons who are, at the time of
grant, employees, officers or directors of, or consultants or advisors to, the
Company or any subsidiaries of the Company as defined in Sections 424(e) and
424(f) of the Code ("Participants"); provided, that Incentive Stock Options may
only be granted to individuals who are employees of the Company (within the
meaning of Section 3401(c) of the Code). A person who has been granted an option
may, if he or she is otherwise eligible, be granted additional options if the
Board of Directors shall so determine.

       (b) Grant of Options to Reporting Persons. The selection of a director or
an officer who is a Reporting Person (as the terms "director" and "officer" are
defined for purposes of Rule 16b-3) as a recipient of an option, the timing of
the option grant, the exercise price of the option and the number of shares
subject to the option shall be determined either (i) by the Board of Directors,
of which all members shall be "disinterested persons" (as hereinafter defined)
or (ii) by a committee consisting of two or more directors having full authority
to act in the matter, each of whom shall be a "disinterested person." For the
purposes of the Plan, a director shall be deemed to be a "disinterested person"
only if such person qualifies as a "disinterested person" within the meaning of
Rule 16b-3, as such term is interpreted from time to time. If at least two of
the members of the Board of Directors do not qualify as a "disinterested person"
within the meaning of Rule 16b-3, as such term is interpreted from time to time,
then the granting of options to officers and directors who are Reporting Persons
under the Plan shall not be determined in accordance with this Section 3(b) but
shall be determined in accordance with the other provisions of the Plan.

4.     Stock Subject to Plan.

       The stock subject to options granted under the Plan shall be shares of
authorized but unissued or reacquired Common Stock. Subject to adjustment as
provided in Section 15 below, the maximum number of shares of Common Stock of
the Company which may be issued and sold under the Plan is 750,000 shares. If an
option granted under the Plan shall expire, terminate or is cancelled for any
reason without having been exercised in full, the unpurchased shares subject to
such option shall again be available for subsequent option grants under the
Plan.

5.     Forms of Option Agreements.

       As a condition to the grant of an option under the Plan, each recipient
of an option shall execute an option agreement in such form not inconsistent
with the Plan as may be approved by the Board of Directors. Such option
agreements may differ among recipients.

                                        2
<PAGE>

6.     Purchase Price.

       (a) General. The purchase price per share of stock deliverable upon the
exercise of an option shall be determined by the Board of Directors at the time
of grant of such option; provided, however, that in the case of an Incentive
Stock Option, the exercise price shall not be less than 100% of the Fair Market
Value (as hereinafter defined) of such stock, at the time of grant of such
option, or less than 110% of such Fair Market Value in the case of options
described in Section 11(b). "Fair Market Value" of a share of Common Stock of
the Company as of a specified date for the purposes of the Plan shall mean the
closing price of a share of the Common Stock on the principal securities
exchange (including the Nasdaq National Market) on which such shares are traded
on the day immediately preceding the date as of which Fair Market Value is being
determined, or on the next preceding date on which such shares are traded if no
shares were traded on such immediately preceding day, or if the shares are not
traded on a securities exchange, Fair Market Value shall be deemed to be the
average of the high bid and low asked prices of the shares in the
over-the-counter market on the day immediately preceding the date as of which
Fair Market Value is being determined or on the next preceding date on which
such high bid and low asked prices were recorded. If the shares are not publicly
traded, Fair Market Value of a share of Common Stock (including, in the case of
any repurchase of shares, any distributions with respect thereto which would be
repurchased with the shares) shall be determined in good faith by the Board of
Directors. In no case shall Fair Market Value be determined with regard to
restrictions other than restrictions which, by their terms, will never lapse.

       (b) Payment of Purchase Price. Options granted under the Plan may provide
for the payment of the exercise price by delivery of cash or a check to the
order of the Company in an amount equal to the exercise price of such options,
or by any other means which the Board of Directors determines are consistent
with the purpose of the Plan and with applicable laws and regulations
(including, without limitation, the provisions of Rule 16b-3 and Regulation T
promulgated by the Federal Reserve Board).

7.     Option Period.

       Subject to earlier termination as provided in the Plan, each option and
all rights thereunder shall expire on such date as determined by the Board of
Directors and set forth in the applicable option agreement, provided, that such
date shall not be later than ten (10) years after the date on which the option
is granted.

8.     Exercise of Options.

       Each option granted under the Plan shall be exercisable either in full or
in installments at such time or times and during such period as shall be set
forth in the option agreement evidencing such option, subject to the provisions
of the Plan. No option granted to a Reporting Person for purposes of the
Exchange Act, however, shall be exercisable during the first six months after
the date of grant. Subject to the requirements in the immediately preceding
sentence, if an option is not at the time of grant immediately exercisable, the
Board of Directors may (i) in the agreement evidencing such option, provide for
the acceleration of the exercise date or dates of the subject option upon the

                                       3
<PAGE>

occurrence of specified events, and/or (ii) at any time prior to the complete
termination of an option, accelerate the exercise date or dates of such option.

9.     Nontransferability of Options.

       No option granted under this Plan shall be assignable or otherwise
transferable by the optionee except by will or by the laws of descent and
distribution or pursuant to a qualified domestic relations order as defined in
the Code or Title I of the Employee Retirement Income Security Act, or the rules
thereunder. An option may be exercised during the lifetime of the optionee only
by the optionee. In the event an optionee dies during his employment by the
Company or any of its subsidiaries, or during the three-month period following
the date of termination of such employment, his option shall thereafter be
exercisable, during the period specified in the option agreement, by his
executors or administrators to the full extent to which such option was
exercisable by the optionee at the time of his death during the periods set
forth in Section 10 or 11(d).

10.    Effect of Termination of Employment or Other Relationship.

       Except as provided in Section 11(d) with respect to Incentive Stock
Options and except as otherwise determined by the Board of Directors at the date
of grant of an option, and subject to the provisions of the Plan, an optionee
may exercise an option at any time within three (3) months following the
termination of the optionee's employment or other relationship with the Company
or within three (3) months if such termination was due to the death or
disability of the optionee or within one (1) year if such termination was due to
the disability of the optionee but, except in the case of the optionee's death,
in no event later than the expiration date of the option. If the termination of
the optionee's employment is for cause or is otherwise attributable to a breach
by the optionee of an employment or confidentiality or non-disclosure agreement,
the option shall expire immediately upon such termination. The Board of
Directors shall have the power to determine what constitutes a termination for
cause or a breach of an employment or confidentiality or non-disclosure
agreement, whether an optionee has been terminated for cause or has breached
such an agreement, and the date upon which such termination for cause or breach
occurs. Any such determinations shall be final and conclusive and binding upon
the optionee.

11. Incentive Stock Options.

       Options granted under the Plan which are intended to be Incentive Stock
Options shall be subject to the following additional terms and conditions:

       (a) Express Designation. All Incentive Stock Options granted under the
Plan shall, at the time of grant, be specifically designated as such in the
option agreement covering such Incentive Stock Options.

       (b) 10% Shareholder. If any employee to whom an Incentive Stock Option is
to be granted under the Plan is, at the time of the grant of such option, the
owner of stock possessing more than 10% of the total combined voting power of
all classes of stock of the Company (after taking into account the attribution
of stock ownership rules of Section 424(d) of the Code), then the following

                                       4
<PAGE>

special provisions shall be applicable to the Incentive Stock Option granted to
such individual:

            (i) The purchase price per share of the Common Stock subject to such
Incentive Stock Option shall not be less than 110% of the Fair Market Value of
one share of Common Stock at the time of grant; and

            (ii) the option exercise period shall not exceed five years from the
date of grant.

       (c) Dollar Limitation. For so long as the Code shall so provide, options
granted to any employee under the Plan (and any other incentive stock option
plans of the Company) which are intended to constitute Incentive Stock Options
shall not constitute Incentive Stock Options to the extent that such options, in
the aggregate, become exercisable for the first time in any one calendar year
for shares of Common Stock with an aggregate Fair Market Value, as of the
respective date or dates of grant, of more than $100,000.

       (d) Termination of Employment, Death or Disability. No Incentive Stock
Option may be exercised unless, at the time of such exercise, the optionee is,
and has been continuously since the date of grant of his or her option, employed
by the Company, except that:

              (i) an Incentive Stock Option may be exercised within the period
            of ninety (90) days after the date the optionee ceases to be an
            employee of the Company (or within such lesser period as may be
            specified in the applicable option agreement); provided, that the
            agreement with respect to such option may designate a longer
            exercise period and that the exercise after such ninety (90) day
            period shall be treated as the exercise of a non-statutory option
            under the Plan;

             (ii) if the optionee dies while in the employ of the Company, or
            within three months after the optionee ceases to be such an
            employee, the Incentive Stock Option may be exercised by the person
            to whom it is transferred by will or the laws of descent and
            distribution within the period of three (3) months after the date of
            death (or within such lesser period as may be specified in the
            applicable option agreement); and

            (iii) if the optionee becomes disabled (within the meaning of
            Section 22(e)(3) of the Code or any successor provisions thereto)
            while in the employ of the Company, the Incentive Stock Option may
            be exercised within the period of one (1) year after the date the
            optionee ceases to be such an employee because of such disability
            (or within such lesser period as may be specified in the applicable
            option agreement).

For all purposes of the Plan and any option granted hereunder, "employment"
shall be defined in accordance with the provisions of Section 1.421-7(h) of the
Income Tax Regulations (or any successor regulations). Notwithstanding the
foregoing provisions, no Incentive Stock Option may be exercised after its
expiration date.

                                        5
<PAGE>

12.    Additional Provisions.

       (a) Additional Option Provisions. The Board of Directors may, in its sole
discretion, include additional provisions in option agreements covering options
granted under the Plan, including without limitation restrictions on transfer,
repurchase rights, rights of first refusal, commitments to pay cash bonuses, to
make, arrange for or guaranty loans or to transfer other property to optionees
upon exercise of options, or such other provisions as shall be determined by the
Board of Directors; provided, that such additional provisions shall not be
inconsistent with any other term or condition of the Plan and such additional
provisions shall not cause any Incentive Stock Option granted under the Plan to
fail to qualify as an Incentive Stock Option within the meaning of Section 422
of the Code.

       (b) Acceleration, Extension, Etc. The Board of Directors may, in its sole
discretion, (i) accelerate the date or dates on which all or any particular
option or options granted under the Plan may be exercised or (ii) extend the
dates during which all, or any particular, option or options granted under the
Plan may be exercised; provided, however, that no such extension shall be
permitted if it would cause the Plan to fail to comply with Section 422 of the
Code or with Rule 16b-3 (if applicable).

13.    General Restrictions.

       (a) Investment Representations. The Company may require any person to
whom an option is granted, as a condition of exercising such option, to give
written assurances in substance and form satisfactory to the Company to the
effect that such person is acquiring the Common Stock subject to the option, for
his or her own account for investment and not with any present intention of
selling or otherwise distributing the same, and to such other effects as the
Company deems necessary or appropriate in order to comply with federal and
applicable state securities laws, or with covenants or representations made by
the Company in connection with any public offering of its Common Stock,
including any "lock-up" or other restriction on transferability.

       (b) Compliance With Securities Law. Each option shall be subject to the
requirement that if, at any time, counsel to the Company shall determine that
the listing, registration or qualification of the shares subject to such option
upon any securities exchange or automated quotation system or under any state or
federal law, or the consent or approval of any governmental or regulatory body,
or that the disclosure of non-public information or the satisfaction of any
other condition is necessary as a condition of, or in connection with the
issuance or purchase of shares thereunder, such option may not be exercised, in
whole or in part, unless such listing, registration, qualification, consent or
approval, or satisfaction of such condition shall have been effected or obtained
on conditions acceptable to the Board of Directors. Nothing herein shall be
deemed to require the Company to apply for or to obtain such listing,
registration or qualification, or to satisfy such condition.

14.    Rights as a Shareholder.

       The holder of an option shall have no rights as a shareholder with
respect to any shares covered by the option (including, without limitation, any
rights to receive dividends or non-cash distributions with respect to such

                                       6
<PAGE>

shares) until the date of issue of a stock certificate to him or her for such
shares. No adjustment shall be made for dividends or other rights for which the
record date is prior to the date such stock certificate is issued.

15.    Adjustment Provisions for Recapitalizations, Reorganizations and Related
Transactions.

       (a) Recapitalizations and Related Transactions. If, through or as a
result of any recapitalization, reclassification, stock dividend, stock split,
reverse stock split or other similar transaction, (i) the outstanding shares of
Common Stock are increased, decreased or exchanged for a different number or
kind of shares or other securities of the Company, or (ii) additional shares or
new or different shares or other non-cash assets are distributed with respect to
such shares of Common Stock or other securities, an appropriate and
proportionate adjustment shall be made in (x) the maximum number and kind of
shares reserved for issuance under or otherwise referred to in the Plan, (y) the
number and kind of shares or other securities subject to any then outstanding
options under the Plan, and (z) the price for each share subject to any then
outstanding options under the Plan, without changing the aggregate purchase
price as to which such options remain exercisable. Notwithstanding the
foregoing, no adjustment shall be made pursuant to this Section 15 if such
adjustment (i) would cause the Plan to fail to comply with Section 422 of the
Code or with Rule 16b-3 or (ii) would be considered as the adoption of a new
plan requiring stockholder approval.

       (b) Reorganization, Merger and Related Transactions. All outstanding
options under the Plan shall become fully exercisable for a period of sixty (60)
days following the occurrence of any Trigger Event, whether or not such options
are then exercisable under the provisions of the applicable agreements relating
thereto. For purposes of the Plan, a "Trigger Event" is any one of the following
events:

              (i) the date on which shares of Common Stock are first purchased
       pursuant to a tender offer or exchange offer (other than such an offer by
       the Company, any Subsidiary, any employee benefit plan of the Company or
       of any Subsidiary or any entity holding shares or other securities of the
       Company for or pursuant to the terms of such plan), whether or not such
       offer is approved or opposed by the Company and regardless of the number
       of shares purchased pursuant to such offer;

             (ii) the date the Company acquires knowledge that any person or
       group deemed a person under Section 13(d)-3 of the Exchange Act (other
       than the Company, any Subsidiary, any employee benefit plan of the
       Company or of any Subsidiary or any entity holding shares of Common Stock
       or other securities of the Company for or pursuant to the terms of any
       such plan or any individual or entity or group or affiliate thereof which
       acquired its beneficial ownership interest prior to the date the Plan was
       adopted by the Board), in a transaction or series of transactions, has
       become the beneficial owner, directly or indirectly (with beneficial
       ownership determined as provided in Rule 13d-3, or any successor rule,
       under the Exchange Act), of securities of the Company entitling the
       person or group to 30% or more of all votes (without consideration of the
       rights of any class or stock to elect directors by a separate class vote)
       to which all shareholders of the Company would be entitled in the
       election of the Board of Directors were an election held on such date;

                                        7
<PAGE>

            (iii) the date, during any period of two consecutive years, when 
       individuals who at the beginning of such period constitute the Board of 
       Directors of the Company cease for any reason to constitute at least a 
       majority thereof, unless the election, or the nomination for election by
       the shareholders of the Company, of each new director was approved by a 
       vote of at least two-thirds of the directors then still in office who 
       were directors at the beginning of such period; and

             (iv) the date of approval by the shareholders of the Company of an
       agreement (a "reorganization agreement") providing for:

                           (A) The merger or consolidation of the Company with 
            another corporation where the shareholders of the Company,
            immediately prior to the merger or consolidation, do not
            beneficially own, immediately after the merger or consolidation,
            shares of the corporation issuing cash or securities in the merger
            or consolidation entitling such shareholders to 80% or more of all
            votes (without consideration of the rights of any class of stock to
            elect directors by a separate class vote) to which all shareholders
            of such corporation would be entitled in the election of directors
            or where the members of the Board of Directors of the Company,
            immediately prior to the merger or consolidation, do not,
            immediately after the merger or consolidation, constitute a majority
            of the Board of Directors of the corporation issuing cash or
            securities in the merger or consolidation; or

                           (B) The sale or other disposition of all or
            substantially all the assets of the Company.

       (c) Board Authority to Make Adjustments. Any adjustments under this
Section 15 will be made by the Board of Directors, whose determination as to
what adjustments, if any, will be made and the extent thereof will be final,
binding and conclusive. No fractional shares will be issued under the Plan on
account of any such adjustments.

16.    Merger, Consolidation, Asset Sale, Liquidation, etc.

       (a) General. In the event of any sale, merger, transfer or acquisition of
the Company or substantially all of the assets of the Company in which the
Company is not the surviving corporation, and provided that after the Company
shall have requested the acquiring or succeeding corporation (or an affiliate
thereof), that equivalent options shall be substituted and such successor
corporation shall have refused or failed to assume all options outstanding under
the Plan or issue substantially equivalent options, then any or all outstanding
options under the Plan shall accelerate and become exercisable in full
immediately prior to such event. The Board of Directors will notify holders of
options under the Plan that any such options shall be fully exercisable for a
period of fifteen (15) days from the date of such notice, and the options will
terminate upon expiration of such notice.

       (b) Substitute Options. The Company may grant options under the Plan in
substitution for options held by employees of another corporation who become
employees of the Company, or a subsidiary of the Company, as the result of a
merger or consolidation of the employing corporation with the Company or a

                                       8
<PAGE>

subsidiary of the Company, or as a result of the acquisition by the Company, or
one of its subsidiaries, of property or stock of the employing corporation. The
Company may direct that substitute options be granted on such terms and
conditions as the Board of Directors considers appropriate in the circumstances.

17.    No Special Employment Rights.

       Nothing contained in the Plan or in any option shall confer upon any
optionee any right with respect to the continuation of his or her employment by
the Company or interfere in any way with the right of the Company at any time to
terminate such employment or to increase or decrease the compensation of the
optionee.

18.    Other Employee Benefits.

       Except as to plans which by their terms include such amounts as
compensation, the amount of any compensation deemed to be received by an
employee as a result of the exercise of an option or the sale of shares received
upon such exercise will not constitute compensation with respect to which any
other employee benefits of such employee are determined, including, without
limitation, benefits under any bonus, pension, profit-sharing, life insurance or
salary continuation plan, except as otherwise specifically determined by the
Board of Directors.

19.    Amendment of the Plan.

       (a) The Board of Directors may at any time, and from time to time, modify
or amend the Plan in any respect; provided, however, that if at any time the
approval of the shareholders of the Company is required under Section 422 of the
Code or any successor provision with respect to Incentive Stock Options, or
under Rule 16b-3, the Board of Directors may not effect such modification or
amendment without such approval; and provided, further, that the provisions of
Section 3(c) hereof shall not be amended more than once every six months, other
than to comport with changes in the Code, the Employer Retirement Income
Security Act of 1974, as amended, or the rules thereunder.

       (b) The modification or amendment of the Plan shall not, without the
consent of an optionee, affect his or her rights under an option previously
granted to him or her. With the consent of the optionee affected, the Board of
Directors may amend outstanding option agreements in a manner not inconsistent
with the Plan. The Board of Directors shall have the right to amend or modify
(i) the terms and provisions of the Plan and of any outstanding Incentive Stock
Options granted under the Plan to the extent necessary to qualify any or all
such options for such favorable federal income tax treatment (including deferral
of taxation upon exercise) as may be afforded incentive stock options under
Section 422 of the Code and (ii) the terms and provisions of the Plan and of any
outstanding option to the extent necessary to ensure the qualification of the
Plan under Rule 16b-3.

20.    Withholding.

       (a) The Company shall have the right to deduct from payments of any kind
otherwise due to the optionee any federal, state or local taxes of any kind
required by law to be withheld with respect to any shares issued upon exercise

                                       9
<PAGE>

of options under the Plan. Subject to the prior approval of the Company, which
may be withheld by the Company in its sole discretion, the optionee may elect to
satisfy such obligations, in whole or in part, (i) by causing the Company to
withhold shares of Common Stock otherwise issuable pursuant to the exercise of
an option or (ii) by delivering to the Company shares of Common Stock already
owned by the optionee. The shares so delivered or withheld shall have a Fair
Market Value equal to such withholding obligation as of the date that the amount
of tax to be withheld is to be determined. An optionee who has made an election
pursuant to this Section 20(a) may only satisfy his or her withholding
obligation with shares of Common Stock which are not subject to any repurchase,
forfeiture, unfulfilled vesting or other similar requirements.

       (b) The acceptance of shares of Common Stock upon exercise of an
Incentive Stock Option shall constitute an agreement by the optionee (i) to
notify the Company if any or all of such shares are disposed of by the optionee
within two years from the date the option was granted or within one year from
the date the shares were issued to the optionee pursuant to the exercise of the
option, and (ii) if required by law, to remit to the Company, at the time of and
in the case of any such disposition, an amount sufficient to satisfy the
Company's federal, state and local withholding tax obligations with respect to
such disposition, whether or not, as to both (i) and (ii), the optionee is in
the employ of the Company at the time of such disposition.

       (c) Notwithstanding the foregoing, in the case of a Reporting Person
whose options have been granted in accordance with the provisions of Section
3(b) herein, no election to use shares for the payment of withholding taxes
shall be effective unless made in compliance with any applicable requirements of
Rule 16b-3.

21.    Cancellation and New Grant of Options, Etc.

       The Board of Directors shall have the authority to effect, at any time
and from time to time, with the consent of the affected optionees, (i) the
cancellation of any or all outstanding options under the Plan and the grant in
substitution therefor of new options under the Plan covering the same or
different numbers of shares of Common Stock and having an option exercise price
per share which may be lower or higher than the exercise price per share of the
cancelled options or (ii) the amendment of the terms of any and all outstanding
options under the Plan to provide an option exercise price per share which is
higher or lower than the then-current exercise price per share of such
outstanding options.

22.    Effective Date and Duration of the Plan.

       (a) Effective Date. The Plan shall become effective when adopted by the
Board of Directors, but no Incentive Stock Option granted under the Plan shall
become exercisable unless and until the Plan shall have been approved by the
Company's shareholders. If such shareholder approval is not obtained within
twelve months after the date of the Board's adoption of the Plan, no options
previously granted under the Plan shall be deemed to be Incentive Stock Options
and no Incentive Stock Options shall be granted thereafter. Amendments to the
Plan not requiring shareholder approval shall become effective when adopted by
the Board of Directors; amendments requiring shareholder approval (as provided

                                       10
<PAGE>

in Section 21) shall become effective when adopted by the Board of Directors,
but no Incentive Stock Option granted after the date of such amendment shall
become exercisable (to the extent that such amendment to the Plan was required
to enable the Company to grant such Incentive Stock Option to a particular
optionee) unless and until such amendment shall have been approved by the
Company's shareholders. If such shareholder approval is not obtained within
twelve months of the Board's adoption of such amendment, any Incentive Stock
Options granted on or after the date of such amendment shall terminate to the
extent that such amendment to the Plan was required to enable the Company to
grant such option to a particular optionee. Subject to this limitation, options
may be granted under the Plan at any time after the effective date and before
the date fixed for termination of the Plan.

       (b) Termination. Unless sooner terminated in accordance with Section 16,
the Plan shall terminate upon the earlier of (i) the close of business on the
day next preceding the tenth anniversary of the date of its adoption by the
Board of Directors, or (ii) the date on which all shares available for issuance
under the Plan shall have been issued pursuant to the exercise or cancellation
of options granted under the Plan. If the date of termination is determined
under (i) above, then options outstanding on such date shall continue to have
force and effect in accordance with the provisions of the instruments evidencing
such options.

23.    Provision for Foreign Participants.

       The Board of Directors may, without amending the Plan, modify awards or
options granted to participants who are foreign nationals or employed outside
the United States to recognize differences in laws, rules, regulations or
customs of such foreign jurisdictions with respect to tax, securities, currency,
employee benefit or other matters.

24.    Governing Law.

       The provisions of this Plan shall be governed and construed in accordance
with the laws of the State of Delaware without regard to the principles of
conflicts of laws.

       Adopted by the Board of Directors on April 2, 1996

                                       11

                                                                       EXHIBIT 5

                                 BRYAN CAVE LLP
                                245 PARK AVENUE
                         NEW YORK, NEW YORK 10167-0034
                                 (212) 692-1800
                           FACSIMILE: (212) 692-1900

ROBERT H. COHEN                                                 (212) 692-1843
                                                            [email protected]

                               September 10, 1996



Cytoclonal Pharmaceutics Inc.
9000 Harry Hines Boulevard
Dallas, Texas  75235

       Re: Registration Statement on Form S-8

Gentlemen:

       We have served as your counsel in connection with the preparation of your
Registration Statement on Form S-8 to be filed with the Securities and Exchange
Commission under the Securities Act of 1933, as amended, representing the
offering and issuance to certain persons under the Cytoclonal Pharmaceutics Inc.
1996 Stock Option Plan (the "Plan") of an aggregate of 750,000 shares of your
common stock, $.01 par value (the "Common Stock").

       We have examined such corporate records, documents and matters of law as
we have considered appropriate for the purposes of this opinion.

       Based upon such examination and our participation in the preparation of
the Registration Statement, it is our opinion that the Common Stock, when issued
in the manner described in the Plan will be validly issued, fully paid and
non-assessable.

       We consent to the reference made to our firm in the Registration
Statement and to the filing of this opinion as an exhibit to the Registration
Statement.

                                       Very truly yours,

                                       /S/ BRYAN CAVE LLP


                                                                   EXHIBIT 23(a)

                         CONSENT OF INDEPENDENT AUDITORS


         We consent to the incorporation by reference in this Registration
Statement on Form S-8 of our report dated February 2, 1996 on the financial
statements of Cytoclonal Pharmaceutics Inc. (the "Company") as at December 31,
1995 and for each of the years in the two-year period ended December 31, 1995
included in the Company's Annual Report on Form 10-KSB.

                                       /s/ RICHARD A. EISNER & COMPANY, LLP

New York, New York
September 6, 1996


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