CYTOCLONAL PHARMACEUTICS INC /DE
SC 13D/A, 1997-10-06
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13D
                                (Amendment No.1)

                    Under the Securities Exchange Act of 1934

                        Cytoclonal Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                     Common Stock, par value $.01 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    23282G105
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


                           Lindsay A. Rosenwald, M.D.
                              c/o Paramount Capital
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

                                 with a copy to:

                              David R. Walner, Esq.
                              c/o Paramount Capital
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4372
- --------------------------------------------------------------------------------
 (Name, Address and Telephone Number of Person Authorized to Receive Notices and
                                 Communications)


                               September 24, 1997
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following:
                                                                            [_] 

Check the following box if a fee is being paid with this Statement:
                                                                            [_]


                               page 1 of 6 pages

<PAGE>

CUSIP No. [23282G105]                  13 D                  Page 2 of  6
 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP     (a)     [ ]

                                                              (b)     [ ]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         PF (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) OR 2(e)
                                                                       [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
- --------------------------------------------------------------------------------
                               7)     SOLE VOTING POWER
                                      306,500
         NUMBER                -------------------------------------------------
         OF                    8)     SHARED VOTING POWER
         SHARES                       392,950
         BENEFICIALLY          -------------------------------------------------
         OWNED BY              9)     SOLE DISPOSITIVE POWER
         EACH                         306,500
         REPORTING             -------------------------------------------------
         PERSON               10)     SHARED DISPOSITIVE POWER
         WITH                         392,950

- --------------------------------------------------------------------------------
11)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
         PERSON

         392,950
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES                                                    [ ]

- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
         4.7% /1/

- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON
         IN
- --------------------------------------------------------------------------------

- --------

     /1/  Includes  86,450  shares of  common  stock of the  Issuer  held by the
     Rosenwald Foundation of which Dr. Rosenwald is a director.


<PAGE>

Item 1.  Security and Issuer.

     (a)  Common Stock, $.01 par value ("Shares")

          Cytoclonal Pharmaceuticals, Inc.
          9000 Harry Hines Blvd.
          Dallas, Texas 95235

Item 2.  Identity and Background.

         Names of Persons Filing:

     (a)  This statement is filed on behalf of Lindsay A. Rosenwald,  M.D. ("Dr.
          Rosenwald").

     (b)  The  business  address of Dr.  Rosenwald is 787 Seventh  Avenue,  48th
          Floor, New York, New York, 10019.

     (c)  Dr.  Rosenwald is an investment  banker,  venture  capitalist and fund
          manager  and  is the  sole  shareholder  of  Paramount  Capital  Asset
          Management,  Inc., a Subchapter S corporation incorporated in Delaware
          ("Paramount Capital"). Paramount Capital is the General Partner of the
          Aries  Domestic  Fund,  L.P.  a limited  partnership  incorporated  in
          Delaware ("Aries Domestic") and is the Investment Manager to The Aries
          Fund, a Cayman Island Trust (the "Aries Trust").  The business address
          of Paramount  Capital and Aries Domestic is 787 Seventh  Avenue,  48th
          Floor,  New York,  New York 10019.  The business  address of the Aries
          Trust is c/o  MeesPierson  (Cayman)  Limited,  P.O. Box 2003,  British
          American Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

     (d)  Dr. Rosenwald has not, during the five years prior to the date hereof,
          been convicted in a criminal proceeding  (excluding traffic violations
          or similar misdemeanors).

     (e)  Dr.  Rosenwald  has not been,  during the five years prior to the date
          hereof,  party to a civil  proceeding of a judicial or  administrative
          body of competent jurisdiction, as a result of which Dr. Rosenwald was
          or is subject to a judgment,  decree or final order  enjoining  future
          violations  of, or  prohibiting  or mandating  activities  subject to,
          Federal or State securities laws or finding any violation with respect
          to such laws.

     (f)  Dr. Rosenwald is a citizen of the United States.

Item 3.  Source and Amount of Funds or Other Consideration.

          On December 30, 1996,  Dr.  Rosenwald  transferred  153,500  shares of
          common stock,  par value $.01,  of the Issuer (the "Common  Stock") to
          the  Rosenwald  Foundation,  a  non-profit  corporation  of which  Dr.
          Rosenwald is a director.  Dr. Rosenwald may be deemed  beneficially to
          own the shares held by the Rosenwald Foundation.  


                                        3

<PAGE>

                                                                               4

          Since  December 30, 1996,  the  Rosenwald  Foundation  has disposed of
          67,050 shares of Common Stock for an approximate  aggregate  return of
          $162,300 and Dr.  Rosenwald  has disposed of 170,000  shares of Common
          Stock for an approximate aggregate gross return of $1,255,637.50, both
          as set forth in Item 5 below.

Item 4.  Purpose of Transaction.

          The  Reporting  Parties  acquired  securities  of  the  Issuer  as  an
          investment in the Issuer.

          In the past sixty (60) days,  the Reporting  Parties have sold certain
          shares  of Common  Stock of the  Issuer  as  reported  in Item 5, and,
          although the  Reporting  Parties have not  formulated  any  definitive
          plans to do so,  they may from time to time  acquire,  dispose  of, or
          engage in other  transactions  with respect to the Common Stock and/or
          other  securities of the Issuer if and when they deem it  appropriate.
          The Reporting Parties may formulate other purposes, plans or proposals
          relating to any of such  securities of the Issuer to the extent deemed
          advisable in light of market conditions, investment policies and other
          factors.

          Except as  indicated  in this  Schedule  13D,  the  Reporting  Parties
          currently have no plans or proposals that relate to or would result in
          any of the matters  described in subparagraphs (a) through (j) of Item
          4 of Schedule 13D.

Item 5.  Interest in Securities of the Issuer.

     (a)  As of October 6,  1997,  Dr.  Rosenwald,  beneficially  owned  392,950
          shares or 4.7% of the Issuer's Common Stock.

     (b)  Dr.  Rosenwald  has the sole power to vote or to direct  the vote,  to
          dispose or to direct the disposition of 326,500 shares.  Dr. Rosenwald
          may be deeemed  to share the power to vote or to direct  the vote,  to
          dispose or to direct the  disposition  of 86,450  shares  owned by the
          Rosenwald Foundation.

     (c)  The following  sales were made by Dr.  Rosenwald in the open market in
          the past 60 days:

          Date                      No. of Shares             Sales Price
          ----                      -------------             -----------
          9/24/97                        10,000                7.587500
          9/26/97                         5,000                7.750000
          9/26/97                         5,000                8.062500
          9/29/97                        15,000                7.587500
          9/30/97                        10,000                7.250000
          9/30/97                        10,000                7.281300
          10/1/97                        20,000                7.133400
          10/2/97                        40,000                7.043000
          10/3/97                        35,000                7.258900


<PAGE>

                                                                               5

          10/6/97                       10,000                 8.062500
          10/6/97                       10,000                 8.250000
                                        
          The following sales were made by the Rosenwald  Foundation in the open
          market in the past 60 days:

          Date                      No. of Shares              Sales Price
          ----                      -------------              -----------
          7/24/97                       1,900                   1.999671
          7/28/97                       2,000                   1.999781
          7/29/97                       2,500                   1.999825
          7/30/97                       2,100                   1.999792
          7/31/97                       2,250                   1.999778
          8/04/97                       2,300                   1.999755
          8/05/97                       2,500                   1.999725
          8/06/97                       2,700                   1.999676
          8/07/97                       3,000                   2.999938
          8/08/97                       3,200                   2.999824
          8/11/97                       3,500                   3.999929
          8/12/97                       2,000                   2.999625
                                    
          Other than as set forth herein the Reporting  Parties have not engaged
          in any  transactions in the Common Stock of the Issuer during the past
          60 days.

          Other than as set forth herein the Reporting  Parties have not engaged
          in any  transactions in the Common Stock of the Issuer during the past
          60 days.

     (d)  Not applicable.

     (e)  On October 3, 1997, Dr. Rosenwald ceased to be the beneficial owner of
          more than five percent (5%) of the Issuer's Common Stock.

Item 6.  Contracts, Arrangements, Understandings or Relationships
         with respect to Securities of the Issuer

          Except as  indicated in this 13D and  exhibits,  there is no contract,
          arrangement,  understanding  or  relationship  between  the  Reporting
          Parties and any other  person,  with respect to any  securities of the
          Issuer.

Item 7.  Material to be Filed as Exhibits:

                  Not Applicable.


<PAGE>


                                                                               6

                                   SIGNATURES

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated:   October 6, 1997
         New York, NY              By /s/ Lindsay A. Rosenwald, M.D
                                      ------------------------------
                                      Lindsay A. Rosenwald, M.D.




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