PROTHERICS PLC
SC 13G/A, 2000-03-24
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1



                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549



                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                               (AMENDMENT NO. 2)*

                                 PROTHERICS PLC
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                  COMMON STOCK

- --------------------------------------------------------------------------------
                           (Title of Class Securities)

                                 Not applicable
                     ---------------------------------------
                                 (CUSIP Number)

                                 March 21, 2000
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

         [ ]      Rule 13d-1(b)

         [ ]      Rule 13d-1(c)

         [ ]      Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).











   POTENTIAL PERSONS WHO ARE TO RESPOND TO THE COLLECTION OF INFORMATION
   CONTAINED IN THIS FORM ARE NOT REQUIRED TO RESPOND UNLESS THE FORM DISPLAYS A
   CURRENTLY VALID OMB CONTROL NUMBER.





                               Page 1 of 4 pages
<PAGE>   2

CUSIP NO.

- --------------------------------------------------------------------------------

   1.   Names of Reporting Persons.
        I.R.S. Identification Nos. of above persons (entities only).

        NOMURA INTERNATIONAL PLC
- --------------------------------------------------------------------------------

   2.   Check the Appropriate Box if a Member of a Group (See Instructions)

        (a)  ...................................................................

        (b)  ...................................................................
- --------------------------------------------------------------------------------

   3.   SEC Use Only............................................................
- --------------------------------------------------------------------------------

   4.   Citizenship or Place of Organization  JAPAN
- --------------------------------------------------------------------------------
- ------------------- -------- ---------------------------------------------------
Number of Shares        5.     Sole Voting Power  8,244,234
Bene-               -----------------------------------------------------------
ficially by             6.     Shared Voting Power  NOT APPLICABLE
Owned by Each       -----------------------------------------------------------
Reporting               7.     Sole Dispositive Power  8,244,234
Person With:        -----------------------------------------------------------
                        8.     Shared Dispositive Power  NOT APPLICABLE
- --------------------------------------------------------------------------------

   9.   Aggregate Amount Beneficially Owned by Each Reporting Person  8,244,234

   10.  Check if the Aggregate Amount in Row (11) Excludes Certain Shares
        (See Instructions)  .....................................

   11.  Percent of Class Represented by Amount in Row (11)  5.2%
- --------------------------------------------------------------------------------

   12.  Type of Reporting Person (See Instructions)  CO
- --------------------------------------------------------------------------------

           .....................................................................


           .....................................................................


           .....................................................................


           .....................................................................


           .....................................................................


           .....................................................................
- --------------------------------------------------------------------------------




                               Page 2 of 4 pages
<PAGE>   3

ITEM 1.
      (a)  Name of Issuer:  Protherics PLC
      (b)  Address of Issuer's Principal Executive Offices: Beechfield House,
           Lyme Green Business Park, Macclesfield, Cheshire, England SK11 0JL

ITEM 2.
      (a)  Name of Person Filing:  Nomura International plc
      (b)  Address of Principal Business Office or, if none, Residence:
           1 St. Martin's-le-Grand, London EC1A 4NP
      (c)  Citizenship: Japan
      (d)  Title of Class of Securities:  Common Stock
      (e)  CUSIP Number: Not applicable.

ITEM 3.   Not Applicable

ITEM 4.       OWNERSHIP

       (a) Amount beneficially owned: 8,244,234

       (b) Percent of class: 5.2%

       (c) Number of shares as to which the person has:

           (i)   Sole power to vote or to direct the vote: 8,244,234

           (ii)  Shared power to vote or to direct the vote: Not applicable

           (iii) Sole power to dispose or to direct the disposition of:
                 8,244,234

           (iv) Shared power to dispose or to direct the disposition of: Not
applicable

ITEM 5.       OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

         Not applicable.

ITEM 6.       OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

         Not applicable.

ITEM 7.       IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
              THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

         Not applicable.

ITEM 8.       IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

         Not applicable.

ITEM 9.       NOTICE OF DISSOLUTION OF GROUP

         Not applicable.

ITEM 10.      CERTIFICATIONS

(a)      Not applicable.

(b)      Not applicable.




                               Page 3 of 4 pages
<PAGE>   4

                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


                                           23 March 2000
                      ----------------------------------------------------------
                                                Date

                                       /s/ Andre Jarmolowicz
                      ----------------------------------------------------------
                                             Signature

                        Andre Jarmolowicz, Compliance and Regulatory Affairs
                      ----------------------------------------------------------
                                             Name/Title



         The original statement shall be signed by each person on whose behalf
the statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative other than an
executive officer or general partner of the filing person, evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature.

NOTE: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See ss.240.13d-7 for other
parties for whom copies are to be sent.

         ATTENTION: INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT CONSTITUTE
FEDERAL CRIMINAL VIOLATIONS (SEE 18 U.S.C. 1001)





                               Page 4 of 4 pages


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