HEMISPHERX BIOPHARMA INC
DEF 14A, 1997-08-26
DRUGS, PROPRIETARIES & DRUGGISTS' SUNDRIES
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                           HEMISPHERx BIOPHARMA, INC.
                               1617 JFK Boulevard
                        Philadelphia, Pennsylvania 19103

                                   ----------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                          TO BE HELD ON OCTOBER 8, 1997

To the Stockholders of Hemispherx Biopharma, Inc.:

     You are cordially  invited to attend the Annual Meeting of  Stockholders of
Hemispherx Biopharma,  Inc. (the "Company"), a Delaware corporation,  to be held
at the Center  City  Holiday  Inn,  Philadelphia,  Pennsylvania,  on  Wednesday,
October 8, 1997, at 10:00 a.m. local time, for the following purposes:

     1.   To elect four  members  to the Board of  Directors  of the  Company to
          serve until their respective successors are elected and qualified;

     2.   To ratify the selection by the Company of KPMG Peat  Marwick,  L.L.P.,
          independent public accountants,  to audit the financial  statements of
          the Company for the year ending December 31, 1997; and

     3.   To transact such other matters as may properly come before the meeting
          or any adjournment thereof.

     Only  stockholders  of record at the close of  business  on August 19, 1997
(the "Record Date"), are entitled to notice of and to vote at the meeting.

     A proxy  statement  and proxy are enclosed  herewith.  If you are unable to
attend the meeting in person you are urged to sign, date and return the enclosed
proxy promptly in the enclosed  addressed  envelope which requires no postage if
mailed within the United  States.  If you attend the meeting in person,  you may
withdraw  your  proxy  and vote  your  shares.  Also  enclosed  herewith  is the
Company's  Annual  Report on Form 10-K for the fiscal  year ended  December  31,
1996.

                                             By Order of the Board of Directors

                                             Peter W. Rodino III, Secretary

Philadelphia, Pennsylvania
July 10, 1997

<PAGE>

PROXY STATEMENT

                           HEMISPHERx BIOPHARMA, INC.
                               1617 JFK Boulevard
                        Philadelphia, Pennsylvania 19103

                                  INTRODUCTION

     This proxy  statement is furnished in connection  with the  solicitation of
proxies for use at the annual meeting (the "Annual  Meeting") of stockholders of
Hemispherx Biopharma, Inc. (the "Company"), to be held on Wednesday,  October 8,
1997, and at any adjournments  thereof.  The accompanying  proxy is solicited by
the Board of Directors of the Company and is  revocable  by the  stockholder  by
notifying the Company's  secretary at any time before it is voted,  or by voting
in person at the Annual  Meeting.  This proxy statement and  accompanying  proxy
will be distributed to  stockholders  beginning on or about August 21, 1997. The
principal  executive  offices of the Company are located at 1617 JFK  Boulevard,
Philadelphia, Pennsylvania 19103, telephone (215) 988-0080.

                      OUTSTANDING SHARES AND VOTING RIGHTS

     Only  stockholders  of record at the close of business on August 19,  1996,
are entitled to receive notice of, and vote at the Annual Meeting.  As of August
19, 1997, the number and class of stock  outstanding and entitled to vote at the
meeting was  16,549,220  shares of common stock,  par value $.001 per share (the
"Common  Stock").  Each  share of Common  Stock is  entitled  to one vote on all
matters.  No other class of securities  will be entitled to vote at the meeting.
There are no cumulative voting rights.

     The nominees  receiving the highest  number of votes cast by the holders of
Common  Stock will be elected as the  Company's  directors  and  constitute  the
entire Board of Directors of the  Company.  The  affirmative  vote of at least a
majority of the shares  represented  and voting at the Annual Meeting at which a
quorum is present (which shares voting  affirmatively also constitute at least a
majority of the required  quorum) is necessary for approval of Proposal No. 2. A
quorum is representation in person or by proxy at the Annual Meeting of at least
one-half of the outstanding shares of the Company.

<PAGE>

                            PROPOSALS TO SHAREHOLDERS

                                 PROPOSAL NO. 1

                              ELECTION OF DIRECTORS

     Each  nominee to the Board of  Directors  will serve  until the next Annual
Meeting of stockholders, or until his earlier resignation,  removal from office,
death or incapacity.

     Unless  otherwise  specified,  the enclosed proxy will be voted in favor of
the  election of William A. Carter,  Peter W. Rodino III,  Cedric C. Philipp and
Richard C. Piani. Information is furnished below with respect to all nominees.

     The  following  information  with respect to the  principal  occupation  or
employment of the nominees,  the name and principal  business of the corporation
or other  organization  in which such occupation or employment is carried on and
other  affiliations and business  experience during the past five years has been
furnished to the Company by the respective nominees:

     WILLIAM A. CARTER, M.D., the co-inventor of Ampligen, joined the Company in
1978,  and has served as (a) the Company's  Chief  Scientific  Officer since May
1989,  (b) the Chairman of the Company's  Board of Directors  since January 1992
(c) the Company's  Chief  Executive  Officer since July 1993,  (d) the Company's
President  since April,  1995, and (e) a director since 1987. From 1987 to 1988,
Dr. Carter served as the Company's  Chairman.  Dr.Carter was a leading innovator
in the  development of human  interferon for a variety of treatment  indications
including  various viral diseases and cancer.  In this context,  he received the
first FDA  approval to initiate  clinical  trials on a beta  interferon  product
manufactured in the U.S. under his  supervision.  From 1985 to October 1988, Dr.
Carter served as the Company's Chief Executive  Officer and Chief Scientist.  He
received his M.D.  degree from Duke  University and underwent his  post-doctoral
training at the National Institutes of Health and Johns Hopkins University.  Dr.
Carter also serves as Professor of Neoplastic Diseases at Hahnemann  University,
a position he has held since 1980. He is also Director of Clinical  Research for
Hahnemann  University's  Institute for Cancer and Blood Diseases. Dr. Carter has
served as a professor at Johns Hopkins School of Medicine,  Hahnemann University
and the State University of New York at Buffalo.

     PETER W. RODINO III has served as a director of the Company since July 1994
and Secretary of the Company since November  1994. He had  previously  served on
the  Company's  Board of  Directors  from 1987 to 1989.  From 1988  through  the
present he has served as  Managing  Partner of the law firm  Rodino and  Rodino,
which  primarily  deals  in  corporate,  commercial,   insurance,  real  estate,
environmental,  bankruptcy and immigration law. He was a partner in the law firm
of Rodino and Scalera,  Inc. from 1988 to 1991. He has served as Chairman of the
Board of  Directors  of the  Foundation  Health Plan of New  Jersey,  an IPA/HMO
providing health care services,  from 1983 to 1988 and as a Director of Columbus
Hospital from 1986 to 1990. Mr. Rodino earned a B.S. in Business  Administration
from Georgetown University in 1973 and J.D. from Seton Hall University School of
Law in 1976.

     RICHARD C. PIANI  serves as  director of the  Company  since May 1995.  Mr.
Piani has been  employed as a  principal  delegate  for  Industry to the City of
Science and Industry, Paris, France, a billion dollar scientific and educational
complex since 1995. Mr. Piani provided  consulting to the Company in 1993,  with
respect to general business strategies for the Company's European operations and
markets.  He served as Chairman of  Industrielle du  Batiment-Morin,  a building
materials corporation, from 1986 


                                        2

<PAGE>

to 1993. Previously he was Professor of International Strategy at Paris Dauphine
University  from  1984 to 1993.  From  1979 to 1985 Mr.  Piani  served  as Group
Director in Charge of International and Commercial  Affairs for RhonePoulenc and
from 1973 to 1979 was  Chairman  and Chief  Executive  Officer  of  Societe  "La
Cellophane",  the French  company which  invented  cellophane  and several other
worldwide  products.  Mr. Piani has a Law degree from  Facilite de Droit,  Paris
Sorbonne  and a Business  Administration  degree  from  Ecola des Hautes  Etudes
Commerciales, Paris.

     CEDRIC C.  PHILIPP has served as a director of the Company  since July 1994
and as Special Advisor for  International  Marketing since 1993. He is President
of Philipp Pharmaceutical Marketing, a consulting firm which he founded in 1987.
From 1957 to 1987, he was with Wyeth International,  a division of American Home
Products,  during which time he served in various  capacities  in  international
marketing and sales, most recently as Executive Assistant to the President.  Mr.
Philipp received his A.B. degree from Columbia College.

THE BOARD OF DIRECTORS  DEEMS  PROPOSAL NO. 1 TO BE IN THE BEST INTERESTS OF THE
COMPANY  AND ITS  STOCKHOLDERS  AND  RECOMMENDS  A VOTE  "FOR"  ALL  FOUR OF THE
ABOVE-NAMED NOMINEE DIRECTORS OF THE COMPANY.

                      INFORMATION CONCERNING BOARD MEETINGS

     The  Company's  Board of  Directors  met twice during the fiscal year ended
December 31, 1996.  The Company's  Compensation  Committee also met twice during
the fiscal year ended December 31, 1996. All of the incumbent Directors attended
at least 75% of such meetings.

                 INFORMATION CONCERNING COMMITTEES OF THE BOARD

     The Board of  Directors  maintains  an Executive  Committee  consisting  of
William A.  Carter and Peter W.  Rodino  III,  which  makes  recommendations  to
management  regarding  general business  matters of the Company;  a Compensation
Committee  consisting  of Peter W. Rodino III and Richard C. Piani,  which makes
recommendations  concerning  salaries  and  compensation  for  employees  of and
consultants to the Company; an Audit Committee  consisting of Cedric C. Philipp,
which reviews the results and scope of the audit and other services  provided by
independent  auditors;  and a Strategic Planning Committee consisting of William
A.   Carter,   Peter  W.  Rodino  III  and  Cedric  C.   Philipp,   which  makes
recommendations  to the Board of priorities in the  application of the Company's
financial  assets and human  resources in the fields of research,  marketing and
manufacturing.


                                        3

<PAGE>

                                   MANAGEMENT

     The current  executive  officers and directors of the Company are set forth
below:

         Name                 Age       Position
         ----                 ---       --------
William A. Carter, M.D.       59        Chairman, Chief Executive Officer, 
                                        President

Robert E. Peterson            60        Chief Financial Officer

R. Douglas Hulse              53        Chief Operating Officer

Cedric C. Philipp             74        Director, Associate Secretary, Special 
                                        Advisor to the Board/International

Richard C. Piani              70        Director

Peter W. Rodino III           43        Director, Secretary

Harris Freedman               63        Vice President, Corporate Communications

Sharon D. Will                38        Vice President, Investor Relations

Josephine M. Dolhancryk       34        Treasurer, Assistant Secretary

David R. Strayer, M.D.        51        Medical Director, Director of Regulatory
                                        Affairs

Carol A. Smith, Ph.D.         45        Director of Manufacturing and Process 
                                        Development

     WILLIAM A. CARTER, M.D., the co-inventor of Ampligen, joined the Company in
1978,  and has served as (a) the Company's  Chief  Scientific  Officer since May
1989,  (b) the Chairman of the Company's  Board of Directors  since January 1992
(c) the Company's  Chief  Executive  Officer since July 1993,  (d) the Company's
President  since April,  1995, and (e) a director since 1987. From 1987 to 1988,
Dr. Carter served as the Company's Chairman.  Dr. Carter was a leading innovator
in the  development of human  interferon for a variety of treatment  indications
including  various viral diseases and cancer.  In this context,  he received the
first FDA  approval to initiate  clinical  trials on a beta  interferon  product
manufactured in the U.S. under his  supervision.  From 1985 to October 1988, Dr.
Carter served as the Company's Chief Executive  Officer and Chief Scientist.  He
received his M.D.  degree from Duke  University and underwent his  post-doctoral
training at the National Institutes of Health and Johns Hopkins University.  Dr.
Carter also serves as Professor of Neoplastic Diseases at Hahnemann  University,
a position he has held since 1980. He is also Director of Clinical  Research for
Hahnemann  University's  Institute for Cancer and Blood Diseases. Dr. Carter has
served as a professor at Johns Hopkins School of Medicine,  Hahnemann University
and the State University of New York at Buffalo.

     ROBERT E.  PETERSON  has served as Chief  Financial  Officer of the Company
since April 1993 and served as an independent  financial  advisor to the Company
from  1989 to April  1993.  Mr.  Peterson  has also  served  since  1990 as Vice
President of the Omni Group, Inc., a business consulting 


                                        4

<PAGE>

group  based in Tulsa,  Oklahoma.  During  the period  1983  through  1992,  Mr.
Peterson was  self-employed  as a financial  consultant to businesses in various
industries.  Mr.  Peterson was Vice  President  and Chief  Financial  Officer of
Pepsico  Foods  International  from 1979 to 1983 and  responsible  for financial
management of this multinational  operating unit with approximately $500 million
in annual revenues. Mr. Peterson is a graduate of Eastern New Mexico University.

     DAVID R.  STRAYER,  M.D.,  who serves as  Professor  of Medicine at Medical
College of  Pennsylvania  and  Hahnemann  University,  has acted as the  Medical
Director of the Company  since 1986. He is Board  Certified in Medical  Oncology
and Internal Medicine with research interests in the fields of cancer and immune
system  disorders.  Dr. Strayer has served as principal  investigator in studies
funded by the Leukemia Society of America,  the American Cancer Society, and the
National  Institutes of Health.  Dr. Strayer  attended the School of Medicine at
the University of California at Los Angeles where he received his M.D. in 1972.

     CAROL A. SMITH, Ph.D. has served as the Company's Director of Manufacturing
and Process  Development  since April 1995, as Director of Operations since 1993
and as the Manager of Quality Control from 1991 to 1993, with responsibility for
the  manufacture,  control and  chemistry of  Ampligen.  Dr. Smith has also been
Scientist/Quality  Assurance Officer for Virotech International,  Inc. from 1989
to 1991 and Director of the Reverse  Transcriptase  and Interferon  Laboratories
and a Clinical  Monitor for Life Sciences,  Inc. from 1983 to 1989. She received
her Ph.D.  from the University of South Florida  College of Medicine in 1980 and
was an NIH post-doctoral  fellow at the Pennsylvania State University College of
Medicine.

     JOSEPHINE M. DOLHANCRYK  joined the Company in 1990 as Office Manager,  was
promoted to Executive Assistant to the Chairman of the Board and Chief Executive
Officer in 1991 and Assistant Secretary,  Treasurer and Executive  Administrator
in 1995.  From 1989 to 1990 Ms.  Dolhancryk  was  President of  Medical/Business
Enterprises.  Ms. Dolhancryk was employed by Children's Hospital of Philadelphia
from 1984 to 1989, where she also served as research coordinator on a drug study
from  1986 to 1988.  Ms.  Dolhancryk  attended  Saint  Joseph's  University  and
Delaware County College.

     CEDRIC C.  PHILIPP has served as a director of the Company  since July 1994
and as Special Advisor for  International  Marketing since 1993. He is President
of Philipp Pharmaceutical Marketing, a consulting firm which he founded in 1987.
From 1957 to 1987, he was with Wyeth International,  a division of American Home
Products,  during which time he served in various  capacities  in  international
marketing and sales, most recently as Executive Assistant to the President.  Mr.
Philipp received his A.B. degree from Columbia College.

     RICHARD C. PIANI has served as a director  of the  Company  since May 1995.
Mr. Piani has been employed as a principal  delegate for Industry to the City of
Science and Industry, Paris, France, a billion dollar scientific and educational
complex since 1995. Mr. Piani provided  consulting to the Company in 1993,  with
respect to general business strategies for the Company's European operations and
markets.  He served as Chairman of  Industrielle du  Batiment-Morin,  a building
materials  corporation,  from  1986 to  1993.  Previously  he was  Professor  of
International Strategy at Paris Dauphine University from 1984 to 1993. From 1979
to 1985 Mr.  Piani  served as Group  Director  in Charge  of  International  and
Commercial  Affairs for  Rhone-Poulenc  and from 1973 to 1979 was  Chairman  and
Chief  Executive  Officer of Societe "La  Cellophane",  the French company which
invented  cellophane and several other worldwide  products.  Mr. Piani has a Law
degree from  Facilite de Droit,  Paris  Sorbonne  and a Business  Administration
degree from Ecola des Hautes Etudes Commerciales, Paris.


                                        5


<PAGE>


     PETER W. RODINO III has served as a director of the Company since July 1994
and Secretary of the Company since November  1994. He had  previously  served on
the  Company's  Board of  Directors  from 1987 to 1989.  From 1988  through  the
present he has served as  Managing  Partner of the law firm  Rodino and  Rodino,
which  primarily  deals  in  corporate,  commercial,   insurance,  real  estate,
environmental,  bankruptcy and immigration law. He was a partner in the law firm
of Rodino and Scalera,  Inc. from 1988 to 1991. He has served as Chairman of the
Board of  Directors  of the  Foundation  Health Plan of New  Jersey,  an IPA/HMO
providing health care services,  from 1983 to 1988 and as a Director of Columbus
Hospital from 1986 to 1990. Mr. Rodino earned a B.S. in Business  Administration
from Georgetown  University in 1973 and a J.D. from Seton Hall University School
of Law in 1976.

     HARRIS FREEDMAN has served as Vice President for Strategic  Alliances since
August 1994 and has been a private  venture  capitalist and business  consultant
for more than the past five years. He is the Secretary of Bridge Ventures,  Inc.
("Bridge  Ventures") and SMACS Holding Corp.,  both of which are private venture
capital companies,  positions he has held for more than five years. His business
experience has encompassed  developing  significant business contacts and acting
as an officer or director of several  companies  in the  pharmaceutical,  health
care and entertainment  fields.  Mr. Freedman was Vice President of U.S. Alcohol
Testing of America,  Inc., from August 1990 to February 1991.  Additionally,  he
was Vice  President--East  Coast  Marketing for  MusicSource  U.S.A.,  Inc. from
October 1992 to January 1994. Mr.  Freedman  attended New York  University  from
1951 to 1954.

     SHARON D. WILL has been Vice  President  for Corporate  Communications  and
Investor Relations since November 1994. Prior to that time, she was a registered
sales  representative  and Senior  Vice  President  for  Institutional  Sales at
Westfield  Financial  Corporation from September 1994 to October 1994. She was a
registered sales  representative  with Marsh Block Corporation from July 1994 to
September 1994. From October 1993 to July 1994 she served as a registered  sales
representative  at Seaboard  Securities Corp. From October 1991 to present,  Ms.
Will  has  been  President  of  Worldwide   Marketing   Inc.  a   manufacturers'
representative  of various  companies  selling to the retail trade markets.  Ms.
Will was the National Sales Manager of Innovo, Inc., a domestic  manufacturer of
textiles,  from October 1989 to November 1991. She attended Baylor College as an
undergraduate for two years with a primary focus on chemistry.

     R. DOUGLAS HULSE was named Chief Operating  Officer on June 1, 1996.  Since
July 1995, he had been Special Advisor for Licensing and New Product Development
to the  Company's  Board of  Directors.  Since 1995 he has  served as  Executive
Director  of The Sage Group,  a health  care  consulting  firm  specializing  in
pharmaceutical and biotechnology  business  development and strategic  planning.
Between 1991 and 1994, Mr. Hulse was Vice President of Business  Development for
Enzon,  Inc.,  a  biopharmaceutical   company  with  proprietary  drug  delivery
technologies,  and  from  1986 to  1991,  Mr.  Hulse  served  as an  independent
financial  and  business   development   consultant  to  various   biotechnology
companies.  He was President and CEO of i-STAT  Corporation,  a manufacturer  of
medical  biosensors,  from 1984 to 1986 and Vice President of Strategic Planning
for Engelhard  Corporation  from 1982 to 1984. Mr. Hulse held several  executive
positions with Halcon International, Inc., a leading chemical company, from 1968
to 1982.  Mr.  Hulse  received  Masters  degrees in  Industrial  Management  and
Chemical  Engineering  Practice from M.I.T.  and a Bachelors degree in Chemistry
from Princeton University.


                                        6

<PAGE>

                             EXECUTIVE COMPENSATION

                           SUMMARY COMPENSATION TABLE
<TABLE>
<CAPTION>

Name and                                                    Other Annual     Restricted Stock      Option           All other
Principal Position               Year     Salary          Compensation($)(1)    Awards($)          Awards      Compensation($)(2)
- ------------------               ----     ------          ------------------ ----------------      ------      ------------------
<S>                              <C>      <C>                      <C>              <C>         <C>                   <C>
William A. Carter                1996     $400,522(3)              --               --              --                7,778
  Chairman of the Board          1995      363,420(3)              --               --            300,000(5)          7,778
  Chief Executive Officer        1994      363,420(3)              --               --          1,400,000(6)          7,778

Robert E. Peterson               1996      128,000                 --               --             50,000(7)            --
  Chief Financial Officer(4)     1995      120,000                 --               --             50,000(8)            --
                                 1994      110,000                 --               --              --                  --
                                          
Sharon Will                      1996      126,000                 --               --              --                  --
  Vice President                 1995      125,000                 --               --             50,000(8)            --
                                 1994        --                    --               --            200,000(9)            --
                                          
David R. Strayer, M.D.           1996      130,427(11)             --               --              --                  --
  Medical Director               1995      115,083                 --               --              --                  --
                                 1994        --                    --               --              --
                                          
Harris Freedman                  1996      126,000                 --               --              --                  --
  Vice President                 1995      112,500                 --               --            150,000(8)            --
                                 1994        --                    --               --            400,000(10)           --
                                          
</TABLE>                                 

(1)  The Company makes available certain  non-monetary  benefits to its officers
     with  a  view  to  attracting   and  retaining   qualified   personnel  and
     facilitating  job  performance.  The Company  considers such benefits to be
     ordinary and incidental business costs and expenses. The aggregate value of
     such benefits, which cannot be precisely ascertained but which is less than
     10% of the cash compensation of each of the above-named executive officers,
     is not included in the table.
(2)  Consists of  insurance  premiums  paid by the Company  with respect to term
     life insurance for the benefit of the named executive officer. (3) Includes
     $63,000  paid to Dr.  Carter by Hahnemann  University  where he serves as a
     professor.
(4)  Mr. Peterson joined the Company in April 1993 and is paid on a fee basis.
(5)  BioAegean  Options to purchase  300,000 shares of common stock of BioAegean
     Corp., a subsidiary of the Company,  at $1.00 per share, which were granted
     in May 1995 (the "BioAegean Options").


                                        7

<PAGE>

(6)  Rule 701 Warrants to purchase  Common  Stock at $3.50 per share  granted in
     October  1994.  These Rule 701 Warrants  vest in 1/3  increments  over a 36
     month period. Rule 701 Warrants are warrants which were issued to officers,
     directors and  consultants  of the Company in reliance upon Rule 701 of the
     Securities Act.
(7)  Warrants to purchase Common Stock at $3.50 purchase granted in March 1996.
(8)  BioAegean Options.
(9)  Rule 701 Warrants to purchase  common  stock at $3.50 per share  granted in
     November 1994.
(10) Rule 701 Warrants to purchase  common  stock at $3.50 per share  granted in
     August 1994.
(11) Includes $80,427 paid to Dr. Strayer by Hahneman University.


                                        8
<PAGE>

      Year End Option Table. The following table sets forth certain  information
regarding  the stock  options  held as of December  31, 1996 by the  individuals
named in the above Summary Compensation Table.

                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                        AND FISCAL YEAR-END OPTION VALUE
<TABLE>
<CAPTION>

                                                                 Securities Underlying                 Value of Unexercised
                                                                 Unexercised Options at                In-the-Money-Options
                                                                   Fiscal Year End(#)                 at Fiscal Year End (9)
                        Shares Acquired         Value        -----------------------------       -------------------------------
  Name                  on Exercise (#)      Realized ($)    Exercisable       Unexercisable     Exercisable       Unexercisable
- ------                  ---------------      ------------    -----------       -------------     -----------       -------------
<S>                          <C>                <C>          <C>                 <C>               <C>                   
William A. Carter            --                 --           1,473,021(1)        766,667(2)        245,000              --
Robert E. Peterson           __                 __              10,368(3)        103,456(4)          --                 --
Sharon Will                  __                 __             513,333(5)        216,667(6)        190,000              --
Harris Freedman              __                 __             989,827(7)        283,333(8)        182,500              --
</TABLE>

- -------------------
(1)  Includes (i) 933,333  currently  exercisable  Rule 701 Warrants to purchase
     Common  Stock at $3.50 per share;  (ii)  73,728  stock  options to purchase
     Common  Stock at $3.50 per share;  (iii) 960  warrants to  purchase  Common
     Stock at $3.50 per share;  and (iv) warrants to purchase  465,500 shares of
     Common Stock at $1.75 per share.

(2)  Includes 300,000  BioAegean  Options,  for which there is no public market,
     and 466,667 Rule 701 Warrants.

(3)  Stock options to purchase Common Stock at $4.34 per share.

(4)  Includes 50,000 BioAegean Options, 50,000 warrants to purchase Common Stock
     at $3.50 per share and 3,456 stock options exercisable at $4.34 per share.

(5)  Includes  133,333  currently  exercisable  Rule 701  Warrants  and  380,000
     warrants to purchase Common Stock at $1.75 per share.

(6)  Includes 150,000 BioAegean Options and 66,667 Rule 701 Warrants.

(7)  Includes (i) 266,667 Rule 701 Warrants currently exercisable;  (ii) 292,161
     warrants  to  purchase  common  stock at $3.50  per  share;  (iii)  365,000
     warrants to purchase Common Stock at $1.75 per share; and (iv) 66,000 Class
     A Warrants to purchase Common Stock at $4.00 per share.

(8)  Includes 133,333 Rule 701 Warrants and 150,000 BioAegean Options.

(9)  Computation  based on $2.25,  the December  31, 1996 closing  price for the
     Common Stock.

                                        9

<PAGE>

     Option Grant Table.  The  following  table sets forth  certain  information
regarding  options granted during the fiscal year ended December 31, 1996 by the
Company to the individuals named in the above Summary Compensation Table:

                        OPTION GRANTS IN LAST FISCAL YEAR

                                     % of Total
                                     Options
                        Options      Granted to
                        Granted      Employees in   Exercise Price    Expiration
Name                    (#)          Fiscal Year    $/Share           Date
- ----                    ---          -----------    -------           ----
Robert E. Peterson      50,000       17%               $3.50          3/1/06


Employment Agreements

     The Company entered into an employment agreement with Sharon Will providing
for her employment as Vice President for Corporate  Communications  and Investor
Relations  on  November  1, 1994.  The  agreement  provides  for Ms.  Will to be
employed  for a one-year  term for a base salary of $120,000  and  provides  for
termination of the agreement upon certain circumstances including termination by
the  Company or Ms.  Will on 14 days  written  notice or the sale of Ms.  Will's
stock in the Company.  Pursuant to the agreement,  Ms. Will was granted Rule 701
Warrants to purchase  200,000 shares of Common Stock of the Company at $3.50 per
share. Ms. Will's  agreement  provides that she shall devote 60% of her business
time,  attention and energies to the Company during regular  business  hours. In
the event that Ms. Will's  employment  is  terminated  for any reason other than
breach  of  contract,  she shall be  entitled  to  receive  accrued  and  unpaid
compensation  plus an additional three months'  compensation.  In July 1995, the
term of Ms.  Will's  employment  agreement  was extended  from one year to three
years.

     The Company  entered  into an  employment  agreement  with Harris  Freedman
providing  for  Mr.  Freedman's  employment  as  Vice  President  for  Strategic
Alliances  on August 1, 1994.  The  agreement  provides  for Mr.  Freedman to be
employed  for a one year term for a base salary of  $120,000  and  provides  for
termination of the agreement upon certain circumstances including termination by
the  Company  or Mr.  Freedman  on 14 days  written  notice  or the  sale of Mr.
Freedman's  stock in the Company.  Pursuant to the agreement,  Mr.  Freedman was
granted  Rule 701  Warrants to purchase  400,000  shares of Common  Stock of the
Company at $3.50 per share.  Mr.  Freedman's  agreement  provides  that he shall
devote 30% of his business  time,  attention and energies to the Company  during
regular  business  hours.  In  the  event  that  Mr.  Freedman's  employment  is
terminated for any reason other than breach of contract, he shall be entitled to
receive  accrued  and  unpaid  compensation  plus an  additional  three  months'
compensation.  In July 1995, the term of Mr. Freedman's employment agreement was
extended from one year to three years.

     The Company entered into an amended and restated employment  agreement with
Dr.  William  A.  Carter,  dated  as of July 1,  1993,  which  provides  for his
employment  until May 8, 1996 at an  initial  base  annual  salary of  $295,832,
subject to annual cost of living increases.  In addition, Dr. Carter may receive
an  annual  performance  bonus  of up to 25% of his  base  salary,  in the  sole
discretion of the Board of Directors.  Dr.  Carter will not  participate  in any
discussions concerning the determination of his annual bonus. Dr. Carter is also
entitled to an  incentive  bonus of 0.5% of the gross  proceeds  received by the
Company from any joint  venture or corporate  partnering  arrangement,  up to an
aggregate maximum incentive bonus of $250,000 for all such  transactions.  It is
contemplated  that Dr.  Carter  will be entitled  to this  incentive  bonus upon
receipt of the gross  proceeds  from the SAB  Agreement  (as defined in "Certain
Transactions").  Dr. Carter's  agreement also provides that he shall be paid his
base  salary  and  benefits  through  May 8,  1996 if he is  terminated  without
"cause,"  as that term is defined in the  agreement.  Pursuant  to his  original
agreement,  as amended  on August 8, 1991,  Dr.  Carter was  granted  options to
purchase  73,728  shares of the Company's  Common Stock at an exercise  price 


                                       10

<PAGE>

of $2.71 per share.  The agreement is  automatically  renewed for successive one
(1) year periods unless written notice of refusal to renew is given by one party
to the other at least 90 days prior to the expiration of the renewal period.

Compensation of Directors

     During  the year ended  December  31,  1996,  each  non-employee  directors
received  $3,750 as  compensation  for serving on the Board of  Directors or any
committee  thereof.  All of the  directors  are  reimbursed  for their  expenses
incurred in  attending  meetings of the Board of Directors  and its  committees.
Non-management  directors receive an annual retainer of $15,000 and will receive
$600 for each Board or committee  meeting they attend and will be reimbursed for
out of pocket  expenses  incurred in attending  meetings.  Certain  non-employee
directors  receive  compensation  as  consultants  to the  Company and have been
granted  options to purchase  Common Stock under the Company's 1990 Stock Option
Plan and Rule 701 Warrants to purchase Common Stock of the Company.  The Company
believes  such  payments  are  necessary in order for the Company to attract and
retain qualified outside directors.

1992 Stock Option Plan

     The Company's 1992 Stock Option Plan ("1992 Plan"),  provides for the grant
of options for the  purchase of up to an  aggregate  of 92,160  shares of Common
Stock to the  Company's  employees,  directors,  consultants  and  others  whose
efforts  are  important  to the  success  of  the  Company.  The  1992  Plan  is
administered by the Compensation Committee of the Board of Directors,  which has
complete  discretion  to select  the  eligible  individuals  to  receive  and to
establish the terms of option grants. The 1992 Plan provides for the issuance of
either non-qualified options or incentive stock options, provided that incentive
stock  options  must be  granted  with an  exercise  price of not less than fair
market value at the time of grant and that  non-qualified  stock options may not
be granted  with an exercise  price of less than 50% of the fair market value at
the time of grant.  The  number of shares of Common  Stock  available  for grant
under the 1992 Plan is subject to adjustment for changes in  capitalization.  To
date, no options have been granted under the 1992 Plan.

1990 Stock Option Plan

     The Company's 1990 Stock Option Plan, as amended  ("1990  Plan"),  provides
for the grant of options to  employees,  directors,  officers,  consultants  and
advisors of the Company for the purchase of up to an aggregate of 460,798 shares
of Common Stock. The plan is administered by the  Compensation  Committee of the
Board of Directors, which has complete discretion to select eligible individuals
to receive and to establish the terms of option grants.  The number of shares of
Common Stock  available  for grant under the 1990 Plan is subject to  adjustment
for changes in  capitalization.  As of December 31, 1996,  options to acquire an
aggregate of 234,953 shares of the Common Stock were outstanding  under the 1990
Plan.

401(K) Plan

     In December  1995,  the Company  established a defined  contribution  plan,
effective  January 1, 1995, the Hemispherx  Biopharma  employees 401(K) Plan and
Trust Agreement (the "401(K) Plan").  All full time employees of the company are
eligible to  participate  in the 401(K) Plan  following one year of  employment.
Subject to certain  limitations  imposed by federal tax laws,  participants  are
eligible to  contribute  up to 15% of their  salary  (including  bonuses  and/or
commissions  per annum.  Participants'  contributions  to the 401(K) Plan may be
matched by the Company at a rate determined  annually by the Board of Directors.
Each participant  immediately vests in his or her deferred salary contributions,
while  Company  contributions  will  vest  over one  year.  In 1996 the  Company
provided  matching  contributions to each employee for up to 6% of annual pay or
$31,580.


                                       11
<PAGE>

Compensation Committee Interlocks and Insider Participation


     During  the  fiscal  year  ended  December  31,  1996,  the  members of the
Company's  Compensation  Committee were William A. Carter,  Peter W. Rodino III,
and E.  Gerald  Kay.  Dr.  Carter is an officer of the  Company.  The  Company's
Compensation  Committee currently consists of Peter W. Rodino III and Richard C.
Piani. The following  transactions  describe certain  relationships  between the
Company and present and former members of the Compensation Committee:

     In May 1995, Dr. Carter,  E. Gerald Kay and certain other  individuals  and
entities  entered  into a 1995  Standby  Financing  Agreement  with the  Company
pursuant  to which they were  collectively  obligated  to invest  during 1995 an
aggregate  of  $5,500,000  in the Company in the event the Company was unable to
secure alternative financing and the Board of Directors determined that the sale
of  securities  to such  persons  was  advisable  (the "1995  Standby  Financing
Agreement"). In exchange for entering into the 1995 Standby Financing Agreement,
the Company issued to each of the parties  ten-year  warrants to purchase 50,000
shares of the Company's Common Stock at an exercise price of $1.75 per share for
each $100,000 of standby financing obligation assumed by the party, resulting in
warrants  to purchase an  aggregate  of  2,750,000  shares of Common  Stock.  In
September 1995, the parties to the 1995 Standby Financing  Agreement,  including
Dr. Carter and Mr. Kay, agreed to extend their obligations  through December 31,
1996.

     In June 1995,  the  directors  of  BioAegean  Corp.,  a  subsidiary  of the
Company,  issued 10-year options to purchase an aggregate of 1,200,000 shares of
common  stock  of  BioAegean  at an  exercise  price  of $1.00  per  share  (the
"BioAegean  Options") to its officers and directors.  The BioAegean  Options are
conditional  upon the recipient's  agreement to serve BioAegean as needed for at
least 24 months unless fully  incapacitated.  William A. Carter, M.D., serves as
Chairman,  Chief  Executive  Officer and a Director of  BioAegean  and  received
300,000  BioAegean  Options.  Peter  W.  Rodino  III  serves  as  Vice-Chairman,
Secretary,  Corporate  Counsel and a director of BioAegean and received  150,000
BioAegean  Options.  Richard C. Piani  serves as a director  and the Advisor for
European Affairs of BioAegean and received 50,000 BioAegean  Options.  E. Gerald
Kay serves as a director for BioAegean and received 50,000 BioAegean Options.

     In March 1995, the Company received an  interest-free  loan from William A.
Carter in the amount of $35,000. In March 1995, the Company repaid the loan from
Dr. Carter.

     In February  1995,  the Company  issued  notes in the  aggregate  principal
amount of $600,000 in connection with the Tisch/Tsai  Restructuring  (as defined
below).  The notes were secured by a pledge by Dr.  Carter of 112,925  shares of
Series C Preferred Stock and 240,756 shares of Common Stock. The notes have been
paid off and the shares are being returned.


                                       12


<PAGE>

                                PERFORMANCE GRAPH

                Total Shareholder Returns - Dividends Reinvested

                            ANNUAL RETURN PERCENTAGE
                                  Month Ending

<TABLE>
<CAPTION>

Company Name/Index        Nov95  Dec95   Jan96   Feb96   Mar96  Apr96  May96   Jun96   Jul96   Aug96   Sep96   Oct96   Nov96  Dec96
- -----------------------------------------------------------------------------------------------------------------------------------
<S>                       <C>     <C>     <C>    <C>      <C>   <C>    <C>     <C>     <C>    <C>      <C>     <C>     <C>   <C>  
HEMISPHERX BIOPHARMA INC. 60.71  (61.10) (11.42) 67.53   (7.69) 64.57 (17.72) (15.39) (45.45) 113.33  (14.85)  11.92  98.18) (35.71)
S&P SMALLCAP 600 INDEX     2.44    1.65    0.22   3.27    2.14   5.74   3.55   (3.92)  (6.88)   6.18    4.39   (0.69)  5.19    1.17
PEER GROUP                26.18   20.00   11.05  (4.52) (15.63)  7.04  21.63  (17.53) (23.91)  12.48   18.58  (11.14)  6.38    1.15
</TABLE>

<TABLE>
<CAPTION>
                Base
Company Name/   Period
 Index          2Nov95 Nov95   Dec95   Jan96   Feb96   Mar96   Apr96   May96   Jun96   Jul96   Aug96   Sep96   Oct96   Nov96  Dec96
- ------------------------------------------------------------------------------------------------------------------------------------
<S>             <C>    <C>      <C>     <C>     <C>     <C>    <C>     <C>      <C>     <C>    <C>      <C>    <C>      <C>    <C>  
HEMISPHERX 
 BIOPHARMA INC. 100    160.71   62.51   55.38   92.77   85.64  140.93  115.95   98.11   53.52  114.18   97.23  108.81   99.91  64.23
S&P SMALLCAP
  600 INDEX     100    102.44  104.13  104.36  107.77  110.08  116.40  120.54  115.81  107.85  114.51  119.53  118.70  124.87 126.33
PEER GROUP      100    126.18  151.42  168.16  160.55  135.46  145.00  176.35  145.44  110.66  124.47  147.60  131.16  139.53 141.13


Peer Group Companies:
- ------------------------------------------------------------------------------------------------------------------------------------
GILEAD SCIENCES INC.
ISIS PHARMACEUTICALS INC.
</TABLE>

                                       13


<PAGE>
                           TOTAL SHAREHOLDER RETURNS



 [The following table was represented as a line graph in the printed material]

                                NEED PLOT POINTS



      Prepared by Standard & Poor's Compusat - Custom Products Division - 7/7/97

                                       14


<PAGE>

                    Security Ownership of Certain Beneficial
                    Owners and Management

     The  following  table  sets  forth,  as of June 27,  1997,  the  record and
beneficial  ownership  of  Common  Stock  of the  Company  by each  officer  and
director,  all officers and  directors as a group,  and each person known to the
Company to own beneficially or of record five percent or more of the outstanding
shares of the Company:

                                     Shares
Officers, Directors and              Beneficially        Percent of Shares
Principal Stockholders               Owned               Beneficially Owned (1)

William A. Carter                    3,733,255(2)                21.0%
R. Douglas Hulse                       172,500(3)                 1.0%
Robert E. Peterson                      64,324(4)                 *
Harris Freedman                      1,285,328(5)                 7.4%
Sharon D. Will                         613,333(6)                 3.6%
Peter W. Rodino III                     31,765(7)                 *
Cedric C. Philipp                       36,333(8)                 *
Richard C. Piani                        18,063(9)                 *
David R. Strayer, M.D.                   8,745                    *
Josephine Dolhancryk                    50,820(10)                *

Jerome Belson                        1,565,000(11)                9.1%
 Belson Enterprises, Inc.
 495 Broadway
 New York, NY 10012

All directors,                       5,963,646                   30.2%
executive officers
as a group (9 persons)

*Less than 1%

(1)  For purposes of this table,  a person or group of persons is deemed to have
     "beneficial  ownership" of any shares of Common Stock which such person has
     the right to  acquire  within 60 days of June 27,  1997.  For  purposes  of
     computing the percentage of outstanding shares of Common Stock held by each
     person or group of persons named above,  any security  which such person or
     persons  has or have the right to acquire  within such date is deemed to be
     outstanding  but is  not  deemed  to be  outstanding  for  the  purpose  of
     computing the percentage ownership of any other person. Except as indicated
     in the  footnotes  to this  table  and  pursuant  to  applicable  community
     property laws, the Company  believes based on information  supplied by such
     persons,  that the  persons  named  in this  table  have  sole  voting  and
     investment  power with  respect to all  shares of Common  Stock  which they
     beneficially own.

(2)  Includes  irrevocable  proxies to vote 1,205,000  shares of Common Stock on
     all matters  that come before the  stockholders  of the Company  until such
     time as (i) the  Company  shall have  achieved a market  capitalization  of
     $300,000,000 or greater for at least 20 consecutive  days of trading in the
     public  markets or (ii) the Company  shall have  received a bona fide offer
     for acquisition or merger,  the net effect of which, if consummated,  would
     be to  establish  a market  capitalization  of the Company of not less than
     $300,000,000.  This proxy shall be terminated  upon the sale of such shares
     in an arm's  length  public sale.  Also  includes (i) an option to purchase
     73,728  shares of Common  Stock from the  Company at an  exercise  price 


                                       15

<PAGE>

     of $2.71 per,  (ii)  warrants to purchase  960 shares of Common Stock at an
     exercise  price of $3.50 per share,  (iii) Rule 701  Warrants  to  purchase
     933,333  shares  of Common  Stock at a price of $3.50  per share  (does not
     include 466,667 which are  non-exercisable);  and (iv) warrants to purchase
     465,000 shares of Common Stock at $1.75 per share issued in connection with
     the 1995 Standby Financing Agreement. Dr. Carter has pledged 112,925 shares
     of Series C Preferred and 240,756  shares of Common Stock to the Tisch/Tsai
     Entities as security for the  repayment of the  $660,000  note  executed in
     March 1995. The note has been paid off and the shares are being returned.

(3)  Includes 172,500 warrants to purchase Common Stock exercisable at $3.50 per
     share held by The Sage Group, of which Mr. Hulse is an Executive  Director.
     Does not  include  100,000  warrant to purchase  Common  Stock at $1.75 per
     share and 217,500 options to purchase Common Stock at $3.50 per share.

(4)  Consists of 13,824 options to purchase Common Stock at an exercise price of
     $4.34 per share and warrants to purchase  50,000  shares of Common Stock at
     an exercise price of $3.50 per share.

(5)  Includes (i) 80,000  shares of Common Stock held by SMACS  Holding Corp. of
     which Mr.  Freedman is an officer;  (ii) 58,000 shares of Common Stock held
     by Bridge Ventures,Inc.  of which Mr. Freedman is an officer,  (iii) 50,000
     shares of Common Stock held by Bridge  Ventures  Defined  Benefit  Plan, of
     which Mr. Freedman is Trustee;  (iv) warrants to purchase 292,161 shares of
     Common  Stock at an  exercise  price of $3.50 per share  owned of record by
     Bridge  Ventures,  Inc.; (v) warrants to purchase  365,000 shares of Common
     Stock which are  exercisable  at $1.75 per share issued in connection  with
     the 1995 Standby  Financing  Agreement owned of record by Bridge  Ventures,
     Inc.; (vi) 266,667 Rule 7arrants to purchase Common Stock of the Company at
     an  exercise   price  of  $3.50  (does  not  include   133,333   which  are
     non-exercisable);  (vii) 86,000 Class A Warrants, 40,000 of which are owned
     by SMACS  Holding Corp.  and 46,000 of which are owned by Bridge  Ventures,
     Inc;  and  (viii)  37,500  shares  of  Common  Stock  underlying  Series  E
     Preferred. Bridge Ventures, Inc. has given an irrevocable proxy to vote its
     58,000 shares to William A. Carter on the same terms as the proxy described
     in Note 2.

(6)  Includes Rule 701 Warrants to purchase 133,333 shares of Common Stock at an
     exercise  price of $3.50  per  share  (does not  include  66,667  which are
     non-exercisable).  Also  includes  100,000  shares of Common Stock owned of
     record by  Worldwide  Marketing,  a company  for which Ms.  Will  serves as
     President.  Also includes  380,000 warrants to purchase Common Stock of the
     Company at an exercise  price of $1.75.  Worldwide  Marketing  has given an
     irrevocable proxy to vote its shares to William A. Carter on the same terms
     as the proxy described in Note 2.

(7)  Includes  Rule 701  Warrants to purchase  13,333  shares of Common Stock at
     $3.50 per share (does not include 6,667 which are non-exercisable).

(8)  Includes (i) Rule 701 Warrants to purchase 13,333 shares of Common Stock at
     $3.50 per share (does not include  6,667 which are  non-exercisable);  (ii)
     options to purchase  20,000 shares of Common Stock at $3.50 per share;  and
     (iii) 2,000 shares of Common Stock and 1,000 Class A Warrants  owned by the
     Cedric C. Philipp and Sue Jones Philipp Trust, of which Mr. Philipp and his
     wife are Trustees.

(9)  Includes  options to purchase  4,608  shares of Common Stock at an exercise
     price of $4.34 and 4,608  shares  of  Common  Stock  owned of record by Mr.
     Piani's wife.

(10) Consists of options to purchase  820 shares of Common  Stock at an exercise
     price of $3.80 and 50,000  Warrants to purchase Common Stock at an exercise
     price of $3.50 per share.

(11) Includes 392,000 Class A Warrants,  of which (i) 25,000 are owned of record
     by Mr.  Belson's  wife;  and (ii)  27,000 are owned of record by The Jerome
     Belson Foundation, of which Mr. Belson is Trustee. Also includes (i) 45,000
     shares of 


                                       16

<PAGE>

     Common Stock owned of record by The Jerome Belson Foundation;  (ii) 125,000
     shares of Common Stock underlying Series E Preferred; and (iii) warrants to
     purchase  550,000 shares of Common Stock at $1.75 per share owned of record
     by Belson Enterprises, Inc. of which Mr. Belson is an officer.


                                       17


<PAGE>

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

     In March  1997,  Bridge  Ventures,  Inc.  purchased  75  shares of Series E
Preferred  at $1,000 per share in a private  offering  pursuant  to Rule 506 the
Securities Act and Regulation D promulgated  thereunder.  The Series E Preferred
is convertible into shares of Common Stock at $2.00 per share.  Harris Freedman,
the Company's Vice President, is an officer of Bridge Ventures, Inc.

     In March  1996,  the  Compensation  Committee  of the  Board  of  Directors
approved a grant of 250,000  warrants  to purchase  common  stock at an exercise
price  of  $3.50  per  share to  Michael  C.  Burrows.  This  grant  was made in
accordance with a Letter  Agreement dated January 15, 1996, in which Mr. Burrows
agreed to provide consulting services to the Company for twenty four months. Mr.
Burrows served as Director of the Company in past years.

     In March 1996 the Compensation Committee of the Board of Directors approved
grants of 50,000 warrants to purchase common stock at an exercise price of $3.50
per share to each of Robert E. Peterson, CFO and Josephine Dolhancryk, Assistant
Secretary of the Company.  Such warrants are not exercisable for a period of one
year from issuance.

     In March 1995, the Company instituted a declaratory judgment action against
a February  noteholder,  Seymour  Cohn, of a $5,000,000  convertible  note and a
secured  defendant in United States  District Court for the Eastern  District of
Pennsylvania  to declare  as void,  set aside,  and  cancel  the  February  1992
convertible note between the Company and Mr. Cohn (the "Note"). In addition, Mr.
Cohn instituted suit against the Company on the Note in the Circuit Court of the
15th Judicial District in and for Palm Beach County,  Florida,  seeking judgment
on the Note, plus attorney fees, costs and expenses; in August 1995, this action
was stayed by the Florida Court pending the outcome of the Pennsylvania  action.
Mr. Cohn also filed a motion for a preliminary  injunction  in the  Pennsylvania
court to enjoin the Company from disbursing the proceeds of a public offering in
the amount of $5.8 million, which motion was granted November, 1995. On February
15, 1996,  the Company  reached an  agreement  to settle this matter.  Terms and
conditions of the settlement  include payment of $6,450,000 to Mr. Cohn to cover
the unpaid  balance Note  balance,  legal  expenses and the retention of certain
warrants granted prior to the lawsuit. The funds under this settlement were paid
on March 21, 1996.  Mutual releases were executed which completed the settlement
of the litigation.

     In January 1996, the Company  engaged the Research  Works,  Inc. to produce
four  research  reports with respect to the  securities of the Company over a 13
month period. In exchange for this service,  the Company granted 60,000 warrants
to the Research Works, Inc. exercisable at $4.00 per share.

     In January 1996, the Company entered into a one year  consulting  agreement
with   Millenium   International   Communications,   Ltd.   ("Millenium").   The
consideration for such services is $120,000, to be paid by the Company in either
monthly payments or balloon  payments,  in the Company's  discretion.  Millenium
shall  consult  with and render  advice to the Company  specifically  concerning
strategic planning, public relations and other related matters. The President of
Millenium,  David C. Drescher is related to Steve Drescher, a former director of
the Company.

     In  December  1995,  the  Company  retained  the law firm of  Akin,  Gump,,
Strauss,  Hauer & Feld, LLP (the "Akin Group") to provide general legal counsel,
advice and representation.  Initially, the Akin Group will represent the Company
in matters pertaining to the Food and Drug Administration ("FDA"). The agreement
includes  incentive  payments  for  obtaining  FDA  approval of Ampligen for HIV
Disease treatment.

     In November 1995, the Company sold 5,313,000 Units of securities through an
initial public offering. Each Unit consists of one share of Common Stock and one
Class A Redeemable Warrant.

     In August 1995, in connection with the settlement of a lawsuit brought by a
former  employee of the Company  against the Company and David  Fries,  a former
director of the Company,  the Company,  Dr. Fries,  the Canaan  Entities and Dr.
William A. 


                                       18

<PAGE>

Carter,  President,  Chairman and CEO of the Company,  entered into an agreement
pursuant to which the Company has agreed to reimburse  Dr. Fries for expenses in
the amount of $50,000  incurred in connection with such  litigation.  As part of
such  agreement,  the parties  agreed to mutual  releases of certain  claims for
expenses and damages arising out of the litigation or arising in connection with
Dr. Fries'  service as a director of the Company.  The payment of $50,000 to Dr.
Fries is evidenced by an  interest-free  promissory  note  pursuant to which the
final  payment is due on or before  November 15, 1995.  The note was assigned to
the Canaan Entities.

     In June 1995,  the Company  entered into an  agreement  with The Sage Group
pursuant  to which The Sage Group has  agreed to  introduce  the  Company to and
assist  the  Company  in  negotiations  with  certain  prospective  distribution
partners listed in the agreement.  In exchange, The Sage Group will receive from
the Company:  (i) a monthly retainer of $5,000 which began accruing July 1, 1995
and (ii) at The Sage Group's  option,  a percentage  of the  proceeds,  up to an
aggregate of $150,000,  from the Company's first  distribution  agreement with a
partner listed in the agreement or the sum of $125,000 from such  agreement.  In
connection  with this  agreement,  the Company will also issue to The Sage Group
warrants to purchase 100,000 shares of the Company's Common Stock at an exercise
price of $1.75 per share.  R. Douglas Hulse, a special  advisor to the Company's
Board of Directors, is the Executive Director of The Sage Group.

     In May 1995, William A. Carter,  M.D.,  President,  Chairman and CEO of the
Company,  Bridge  Ventures,  Sharon  Will,  a Vice  President  of  the  Company,
Associated  Funding  Services,  Inc.,  Jerome  Belson,  a director of one of the
Company's subsidiaries and a principal shareholder and E. Gerald Kay, a director
of the Company, entered into a 1995 Standby Financing Agreement with the Company
pursuant  to which they are  collectively  obligated  to invest  during  1995 an
aggregate  of  $5,500,000  in the  Company in the event the Company is unable to
secure alternative financing and the Board of Directors determines that the sale
of securities  to such persons is  advisable.  In exchange for entering into the
1995  Standby  Financing  Agreement,  the Company  issued to each of the parties
ten-year  warrants to purchase 50,000 shares of the Company's Common Stock at an
exercise  price of $1.75  per  share  for each  $100,000  of  standby  financing
obligation assumed by the party,  resulting in warrants to purchase an aggregate
of 2,750,000  shares of Common Stock.  In September  1995, the parties agreed to
extend their  obligations  under the 1995 Standby  Financing  Agreement  through
December 31, 1996.  Harris  Freedman,  a Vice President of the Company,  and his
wife are officers of Bridge Ventures.  Gerald Brauser is President of Associated
Funding Services, Inc.

     In June 1995, the Board of Directors of BioAegean Corp, a subsidiary of the
Company, issued an aggregate of 1,200,000 BioAegean Options at an exercise price
of $1.00 per share to its officers and directors, including certain officers and
directors  of the Company.  In  consideration  for the  BioAegean  Options,  the
recipients agreed to serve BioAegean's needs for at least 24 months unless fully
incapacitated.  William A. Carter, M.D., Chairman, President and Chief Executive
Officer of the  Company,  serves as  Chairman,  Chief  Executive  Officer  and a
Director of BioAegean and received 300,000  BioAegean  Options.  Peter W. Rodino
III,  a  director  and  Secretary  of  the  Company,  serves  as  Vice-Chairman,
Secretary,  Corporate  Counsel and a director of BioAegean and received  150,000
BioAegean Options. Robert Peterson serves as Chief Financial Officer of both the
Company and BioAegean and received 50,000 BioAegean  Options.  Sharon Will, Vice
President of Investor  Relations and Corporate  Communications  for the Company,
serves as Vice  President  of  Marketing  for  BioAegean  and  received  150,000
BioAegean  Options.  Harris  Freedman  serves as Vice  President  for  Strategic
Alliances  for both the Company and  BioAegean  and received  150,000  BioAegean
Options.  Richard C. Piani, a director of the Company,  serves as a director and
the Advisor for European  Affairs of BioAegean  and  received  50,000  BioAegean
Options.  E. Gerald Kay serves as a director for both the Company and  BioAegean
and received 50,000 BioAegean Options.  BioAegean's  remaining director,  Jerome
Belson,  a principal  stockholder  of the  Company,  received  50,000  BioAegean
Options.

     In March 1995, the Company  issued the Original  Brauser Note, to Gerald A.
Brauser in the  principal  amount of $200,000.  The  Original  Brauser Note also
provided for the issuance of warrants to purchase 50,000 shares of the Company's
Common  Stock at $1.75 per share.  In May 1995,  the  Company  restructured  the
Original  Brauser  Note and issued the New  Brauser  Note to Mr.  Brauser in the
amount  of  $100,000  along  with  warrants  to  purchase  25,000  shares of the
Company's  Common Stock at $1.75 per share.  As part of the  restructuring,  Mr.
Brauser  agreed to (i) purchase  100,000  shares of Common Stock with $50,000 of
the 


                                       19


<PAGE>

Original  Brauser  Note and (ii) apply  $50,000  of the  Original  Brauser  Note
towards a Bridge Loan in connection with the Bridge  Financing.  The New Brauser
Note of $100,000 and the $50,000  Bridge Loan have been paid off. In  connection
with both the Original  Brauser Note and the New Brauser Note,  Bridge  Ventures
agreed to permit the Company to  collateralize  these  notes with the  Company's
patent estate,  which collateral had previously been granted to Bridge Ventures.
Bridge  Ventures  further  guaranteed  the  Original  Brauser  Note with certain
publicly  traded common stock,  which  guarantee was released by Mr.  Brauser in
connection  with the  restructuring.  Harris  Freedman,  a Vice President of the
Company, and his wife are both officers of Bridge Ventures.

     In March and April  1995,  in  connection  with the Bridge  Financing,  the
Company issued Bridge Notes to certain lenders in the aggregate principal amount
of  $1,500,000,  including  a Bridge  Note in the amount of  $250,000 to Stephen
Drescher  and a  Bridge  Note  in the  amount  of  $150,000  to  Jerome  Belson.
Additionally,  in  connection  with the Bridge  Loans,  the  Company  has issued
options to purchase 166,665 Bridge Units at $.50 per Bridge Unit to Mr. Drescher
and options to purchase  100,000  Bridge Units at $.50 per Bridge Unit to Jerome
Belson.  In July 1995, Mr.  Drescher  assigned the $250,000  Bridge Note and his
options to  purchase  166,665  Bridge  Units to  certain  other  investors.  Mr.
Drescher  is a former  director  of the  Company  and  presently  serves  as the
Director of Corporate Finance at Monroe Parker, one of the Underwriters.  Jerome
Belson is a principal shareholder and director of BioAegean, a subsidiary of the
Company.

     In March 1995,  the Company  received  interest-free  loans from William A.
Carter and Harris Freedman in the amounts of $35,000 and $12,000,  respectively.
In March 1995, the Company  repaid the loan from Dr. Carter.  In April 1995, the
Company repaid the loan from Mr. Freedman.

     In December 1992 and February  1993,  the Company  issued to the Tisch/Tsai
Entities,  in a private placement,  promissory notes in the aggregate  principal
amount  of  $2,400,000  due on April 30,  1994,  and  warrants  to  purchase  an
aggregate of 36,864  shares of the  Company's  Common Stock or 40,000  shares of
Series C Preferred  Stock at an  exercise  price of the (i) $13.02 or $12.00 per
share,  respectively  or (ii) the per share price of Common Stock in the initial
public  offering.  The warrants  expire on December  31,  1997.  One-half of the
principal amount of the notes and one-half of the warrants were purchased by FLF
Associates.  James S. Tisch, a former director of the Company, is a principal of
FLF  Associates.  The  remaining  half of the  principal  amount of the note and
one-half of the warrants  were  purchased by Gerald Tsai,  Jr. and Lincoln Trust
Company,  Custodian  FBO Gerald Tsai,  Jr. Mr. Tsai is a former  director of the
Company. Interest on the notes is payable quarterly at an annual rate of 12% (6%
prior to May 1, 1993).

     In February  1995,  the Company  entered a  settlement  agreement  with the
Tisch/Tsai   Entities  to  restructure  the  December  1992  and  February  1993
promissory  notes in the aggregate  principal  amount of  $2,400,000  and settle
certain  threatened  claims made by the Tisch/Tsai  Entities against the Company
(the "Tisch/Tsai  Restructuring").  This debt restructuring consisted of (i) the
repayment  by the  Company of  $1,200,000  in  principal,  (ii) the  issuance of
replacement  notes  in  the  aggregate  principal  amount  of  $600,000  to  the
Tisch/Tsai  Entities  which  notes are due on the  earlier  of the  closing of a
public  offering or May 28, 1996 and bear  interest at the rate of 8% per annum,
which  interest is payable in quarterly  installments  from an interest  reserve
established  by the Company,  (iii) the conversion of $600,000 of principal into
172,414 shares of Series C Preferred Stock at the rate of $3.48 per share,  (iv)
the amendment and restatement of certain  warrants issued in connection with the
original  notes in order to  increase  the  number of  shares of stock  issuable
thereunder  by 64,000  shares to provide  for  warrants  to  purchase a total of
144,000  shares of Common Stock at an exercise  price of $2.00 per share,  which
warrants are  exercisable  until  December 31, 1997,  and (v) the release by all
parties of any claims.  The  replacement  notes were  secured by a pledge by Dr.
William A.  Carter,  President,  Chief  Executive  Officer  and  Chairman of the
Company,  of 112,925  shares of Series C Preferred  Stock and 240,756  shares of
Common Stock.  In March,  1996 the notes were repaid and the shares of stock are
being returned.

     In November 1994,  the Company  restructured a $100,000 note issued in June
1993 to Myron Cherry (the "Cherry Note"),  a stockholder,  pursuant to which the
repayment  date of the  principal  amount of the Cherry Note was extended to the
closing date of the Company's initial public offering and the accrued but unpaid
interest subsequent to September 30, 1993 was converted into Common Stock of the
Company at a price of $5.43 per share.  Pursuant  to the  restructuring,  in the
event that the Company's  initial 


                                       20


<PAGE>

public  offering was not completed by February 28, 1995,  the  principal  amount
would be repaid by the  Company or Bridge  Ventures  Inc.  by March 6, 1995.  In
addition,  the  Company  issued  to Mr.  Cherry  5,000  immediately  exercisable
warrants with an exercise  price of $3.50 per share and Bridge  Ventures  agreed
that the unpaid  principal  on the Cherry  Note would be  collateralized  by the
Company's  patents on the same terms as the Bridge Financing  arranged by Bridge
Ventures.  In March  1995,  the  Company  and Mr.  Cherry  agreed to extend  the
maturity of the  promissory  note from March 1, 1995 to March 31,  1995.  During
this extended period, the Company agreed to pay 8% interest and grant Mr. Cherry
a warrant to purchase  5,000 shares of Common Stock  exercisable  at $3.50.  The
Company  further agreed to either  register all of Mr.  Cherry's 2,770 shares of
Common Stock and 10,000  warrants to purchase  Common Stock in  connection  with
this Public  Offering or reduce the exercise price of Mr.  Cherry's  warrants to
$1.75 per share. Because Mr. Cherry has not advised the Company of his election,
the Company has reduced the  exercise  price of his warrants to $1.75 per share.
As of July,  1995,  the  Company has repaid the entire  principal  amount of the
Note,  including  accrued  interest.  Harris  Freedman,  a Vice President of the
Company, and his wife are officers of Bridge Ventures.

     In October and  November  1994,  the Company  granted  Rule 701 Warrants to
purchase  20,000  shares of Common  Stock at $3.50 per share to E.  Gerald  Kay,
Cedric C.  Philipp and Peter  Rodino III,  directors  of the Company and Maryann
Charlap  Azzato,  a former  director of the Company.  In  addition,  the Company
granted the  following  Rule 701 Warrants to purchase  shares of Common Stock at
$3.50 per share:  1,400,000  warrants to William A. Carter;  200,000 warrants to
Sharon Will, Vice President of Investor Relations and Corporate  Communications;
and 400,000 warrants to Harris Freedman, Vice President for Strategic Alliances.

     From July 1994 to November 1994, the Company  completed a private placement
in which  it sold  2,050,000  shares  of  Common  Stock  to  certain  accredited
investors for an aggregate  consideration  of $1,025,000 (the "1994 Common Stock
Financing").   In  connection  with  the  private  placement,   Bridge  Ventures
introduced a number of investors  and lenders to the Company.  Harris  Freedman,
Vice President of the Company, and his wife are officers of Bridge Ventures.  In
conjunction  with the  1994  Common  Stock  Financing,  the  Company  agreed  to
collateralize  certain of its patents until the earlier of the  effectiveness of
the initial  public  offering or the  consummation  of  corporate  alliances  or
licensing  arrangement which provide  sufficient  operating capital and clinical
development  support to the  Company.  Pursuant  to the  agreement  with  Bridge
Ventures in connection with the 1994 Common Stock  Financing,  Messrs.  Philipp,
Rodino and Kay were elected to the Board of  Directors.  Purchasers of 1,950,000
of the shares of Common Stock issued pursuant to the 1994 Common Stock Financing
executed  irrevocable proxies naming William A. Carter, the Company's President,
Chief Executive  Officer and Chairman,  as proxy,  with full power to vote their
shares on all matters to be voted on by the  stockholders  of the Company  until
the  achievement by the Company of a market  capitalization  of  $300,000,000 or
greater under certain circumstances or the receipt by the Company of a bona fide
offer for acquisition or merger, the net effect of which, if consummated,  would
be to establish a market capitalization of at least $300,000,000.

     In October 1994, in connection  with the 1994 Common Stock  Financing,  the
Company  sold  50,000  shares  of  Common  Stock at a price of $.50 per share to
Stephen J. Drescher,  a former director of the Company,  80,000 shares of Common
Stock to the Belfort Family Trust, of which Mr. Drescher serves as Trustee, at a
price of $.50 per share and 50,000 shares of Common Stock at a price of $.50 per
share to Jerome  Belson,  a director of  BioAegean.  Mr.  Drescher also received
300,000 warrants in connection with general consulting services. In addition, in
October 1994,  the Company  received a certain loan in the  aggregate  principal
amount of $150,000 from the Belfort  Family Trust.  In March 1995,  the loan was
repaid  without  interest from the proceeds  from the Bridge  Loans.  In October
1995,  the  Belfort  Family  Trust sold 80,000  shares of Common  Stock to Carol
Schiller at a price of $2.00 per share.

     In October  1994,  the Company  entered  into an agreement  with  Bioclones
Proprietary  Limited  ("Bioclones"),   a  biopharmaceutical   company  which  is
associated with The South African Breweries Limited ("SAB").  In connection with
the  execution  of SAB  Agreement,  the Company  granted  Cedric C.  Philipp,  a
Director of the Company,  an option to purchase 20,000 shares of Common Stock at
$3.50 per share. In addition, in October 1994, the Board of Directors granted to
Mr.  Philipp,  a director of the  Company  and Special  Advisor to the Board for
International  Marketing,  the right to receive 3% of the gross  


                                       21


<PAGE>

proceeds of any  licensing  fees and prepaid  royalties  received by the Company
pursuant to the SAB Agreement  and a fee of .75% of gross  proceeds in the event
that  SAB/Bioclones  makes a tender  offer for all or  substantially  all of the
Company's assets,  including a merger,  acquisition or related  transaction.  In
addition,  the Company further agreed to provide a monthly retainer of $2,000 to
Mr. Philip in exchange for consulting  services and  remuneration  for corporate
alliances which are principally  introduced by Mr. Philipp. Mr. Philipp has been
paid $90,000 to date in connection with these arrangements.

     In September  1994,  Maryann  Charlap  Azzato,  formerly Vice  President of
Investor Relations and Corporate Communications and the former Vice Chairman and
director  of the  Company,  entered  into  an  agreement  with  Lloyd  DeVos,  a
stockholder,  former  director and holder of a note in the  principal  amount of
$100,000  (the  "DeVos  Note") in order to settle a lawsuit  filed  against  the
Company and William A. Carter by Mr. DeVos in the United States  District  Court
for the Southern  District of New York alleging  breach of contract,  conversion
and certain  violations of the federal  securities  laws in connection  with the
issuance of the DeVos Note. Pursuant to the settle ment agreement, principal and
interest on the DeVos Note were repaid by Ms. Azzato as well as certain expenses
incurred by Mr.  DeVos in the  approximate  amount of $2,600 and 1,536 shares of
Common  Stock of the Company  were  transferred  to Mr.  DeVos by Ms.  Azzato in
exchange for the assignment to Ms. Azzato by Mr. DeVos of the right to repayment
by the Company of the DeVos Note and warrants to purchase  1,667 share of Series
C Preferred  Stock.  In addition,  certain  options to purchase  6,912 shares of
Common Stock of the Company previously issued to Mr. DeVos were delivered to Mr.
DeVos. In exchange for the above  agreement,  Mr. DeVos, the Company and William
A. Carter  executed  mutual  releases of all claims and Mr. DeVos  dismissed the
suit.

     In September 1994, the Company incorporated three wholly-owned subsidiaries
- - BioPro Corp.  ("BioPro"),  Core BioTech,  Corp. ("Core BioTech") and BioAegean
Corp. - in Delaware.  In September 1994, the Company granted exclusive worldwide
licenses and/or sublicenses to certain of its patents and assigned certain other
patents  to BioPro  (the  "BioPro  License"),  Core  BioTech  (the  "CoreBiotech
License") and BioAegean (the "BioAegean  License").  Bridge Ventures,  which has
rights  in the  Company's  patents  pursuant  to the  collateralization  of such
patents in connection  with the 1994 Common Stock  Financing,  agreed to release
its rights in the  licensed  or  assigned  patents.  Harris  Freedman,  the Vice
President for Strategic  Alliances for the Company and  BioAegean,  and his wife
are officers of Bridge Ventures.

     In May 1994, the Company  entered into an agreement to borrow $100,000 from
Bridge  Ventures for 60 days in exchange for warrants to purchase  92,160 shares
of Common  Stock at $3.50 per  share.  In August  1994,  the  $100,000  loan was
converted to 200,000  shares of Common  Stock and  warrants to purchase  200,000
shares of Common Stock at an exercise price of $3.50 per share.  Bridge Ventures
transferred  150,000 of its shares of Common  Stock to Gerald Kay, a director of
the Company. In addition,  Bridge Ventures received a $50,000 consulting fee for
general business and financial consulting services rendered from January 1994 to
July 1994, which it converted into 100,000 shares of Common Stock as part of the
1994 Common Stock Financing.  Harris Freedman, the Company's Vice President, and
his wife are officers of Bridge Ventures.  Pursuant to the agreement with Bridge
Ventures,  Messrs.  Kay,  Philipp  and  Rodino  were  elected  to the  Board  of
Directors.  In November 1994, each of Bridge Ventures and Gerald Kay sold 50,000
shares of  Common  Stock at a price of $.50 per  share to  Worldwide  Marketing.
Sharon Will, an officer of the Company, is President of Worldwide Marketing.

     In April  1994,  William  A.  Carter,  the  Company's  Chairman  and  Chief
Executive Officer,  purchased 20,000 shares of Series C Preferred Stock at $5.00
per share.  Also Maryann  Charlap  Azzato  purchased  30,000  shares of Series C
Preferred  Stock at $5.00 per share and agreed to purchase an additional  10,000
shares at $5.00 per share.

     In May 1994,  Maryann Charlap Azzato  guaranteed  payment of two promissory
notes in the  aggregate  amount of $76,000  payable by the Company  representing
payments due in connection with the Temple  Agreement (the "Temple  Notes").  In
return for the guarantee,  the Company assigned all rights,  patents and related
technology  in the Company's  Oragen and Diagen  products to Ms.  Azzato,  which
rights will revert to the Company upon  repayment of the principal on the Temple
Notes, 12% interest, and Ms. Azzato's fees and expenses which are expected to be
paid from the  proceeds of this Public  Offering.  The Company  also  received a
right of first  refusal with respect to the sale or  assignment by Ms. Azzato of
this technology.


                                       22
<PAGE>

      In January  1994,  William A.  Carter,  the  Company's  Chairman and Chief
Executive Officer,  sold an aggregate of 122,880 shares of Common Stock at $3.26
per  share  for an  aggregate  price  of  $400,000  to  Michael  Dubilier,  Keys
Foundation,  Canaan  Venture  Limited  Partnership  ("Canaan  Venture"),  Canaan
Venture Offshore Limited Partnership,  C.V. ("Canaan Offshore"), James Tisch and
an  unaffiliated  individual.  Using  the  proceeds  of this  sale,  Dr.  Carter
purchased  80,000 shares of Series C Preferred Stock at $5.00 per share from the
Company. In addition,  Maryann Charlap Azzato purchased 3,600 shares of Series C
Preferred  Stock at $5.00 for an aggregate  price of $18,000,  representing  her
remaining commitment under the 1993 Standby Financing Agreement.

Compliance with Section 16(a) of the Exchange Act

     R. Douglas Hulse did not timely file a Form 3 upon his appointment as Chief
Operating Officer.  William A. Carter, Harris Freedman, David R. Strayer, Robert
E.  Peterson,  E. Gerald Kay,  Cedric C.  Philipp and Sharon Will did not timely
file respective Forms 4 in connection with transactions made in fiscal 1996. All
applicable individuals have since since complied with Section 16 of the Act.


                                       23

<PAGE>

                                 PROPOSAL NO. 2

                      RATIFICATION OF SELECTION OF AUDITORS

     The firm of KPMG Peat  Marwick,  L.L.P.  audited the  consolidated  balance
sheets of the Company and its  subsidiaries  for the fiscal years ended December
31,  1995  and 1996  and the  related  consolidated  statements  of  operations,
stockholders'  equity  (deficit),  and cash  flows  for each of the years in the
three-year period ended December 31, 1996. On August 6, 1997, pursuant to a vote
of the Board of Directors, the firm of KPMG Peat Marwick, L.L.P. was selected to
audit the financial  statements of the Company for the year ending  December 31,
1997. Accordingly, the Board of Directors will offer the following resolution at
the Annual Meeting:

         RESOLVED,  that the  appointment by the Board of Directors of KPMG Peat
         Marwick, L.L.P. independent public accountants,  to audit the financial
         statements of the Company for the year ending December 31, 1997 be, and
         hereby is, ratified and approved.

     It is  anticipated  that a member  of KPMG  Peat  Marwick,  L.L.P.  will be
present at the Annual Meeting to respond to appropriate  questions and will have
the opportunity, if he desires, to make a statement.

     The affirmative  vote of at least a majority of the shares  represented and
voting at the Annual  Meeting at which a quorum is present  (which shares voting
affirmatively  also  constitute  at least a majority of the required  quorum) is
necessary  for  approval of Proposal  No. 2. Under  Delaware  law,  there are no
rights of appraisal or  dissenter's  rights which arise as a result of a vote to
ratify the selection of auditor's.

THE BOARD OF DIRECTORS  DEEMS  PROPOSAL NO. 2 TO BE IN THE BEST INTERESTS OF THE
COMPANY AND ITS STOCKHOLDERS AND RECOMMENDS A VOTE "FOR" APPROVAL THEREOF.

                             STOCKHOLDERS' PROPOSALS

     It is anticipated  that the Company's  1998 Annual Meeting of  Stockholders
will be held in July 1998.  Stockholders  who seek to present  proposals  at the
Company's next Annual Meeting of Stockholders must submit their proposals to the
Secretary of the Company on or before March 1, 1998.


                                       24

<PAGE>

                                     GENERAL

     Unless  contrary  instructions  are  indicated on the proxy,  all shares of
Common Stock represented by valid proxies received pursuant to this solicitation
(and not revoked before they are voted) will be voted FOR Proposal No. 2 and for
the election of all directors nominated.

     The Board of Directors knows of no business other than that set forth above
to be  transacted at the meeting,  but if other matters  requiring a vote of the
stockholders  arise,  the persons  designated as proxies will vote the shares of
Common Stock  represented  by the proxies in accordance  with their  judgment on
such matters. If a stockholder specifies a different choice on the proxy, his or
her shares of Common Stock will be voted in accordance with the specification so
made.

IT IS IMPORTANT THAT PROXIES BE RETURNED PROMPTLY.  WE URGE YOU TO FILL IN, SIGN
AND RETURN THE ACCOMPANYING FORM OF PROXY IN THE PREPAID ENVELOPE  PROVIDED,  NO
MATTER HOW LARGE OR SMALL YOUR HOLDINGS MAY BE.


                                      By Order of the Board of Directors,
                                      Peter W. Rodino III, Secretary

Philadelphia, Pennsylvania
July 10, 1997


                                       25
<PAGE>


                           HEMISPHERx BIOPHARMA, INC.

          Annual Meeting of Stockholders -- Wednesday, October 8, 1997

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     The undersigned  hereby appoints  William A. Carter and Peter W. Rodino III
and each of them,  with  power of  substitution,  as proxies  to  represent  the
undersigned  at the Annual  Meeting of  Stockholders  to be held at Center  City
Holiday Inn,  Philadelphia,  Pennsylvania,  Wednesday,  October 8, 1997 at 10:00
a.m. local time and at any adjournment  thereof, and to vote the shares of stock
the undersigned would be entitled to vote if personally  present, as indicted on
the reverse side hereof.

     The  shares  represented  by the  proxy  will be voted as  directed.  If no
contrary  instruction is given,  the shares will be voted FOR Proposal No. 2 and
for the  election of William A. Carter,  Peter W. Rodino III,  Cedric C. Philipp
and Richard C. Piani as Directors.

Please mark boxes in blue or black ink.

1.    Proposal No. 1 - Election of Directors.

      Nominees:  William A. Carter, Peter W. Rodino III, Cedric C. Philipp and 
      Richard C. Piani.

                             AUTHORITY
           FOR               withheld
           all              as to all
         nominees            nominees

           / /                 / /
                        
      For, except authority withheld as to the following nominee(s):

      ______________________________________________________________

2.   Proposal No. 2 for  ratification  of the  selection  of KPMG Peat  Marwick,
     L.L.P. as the independent auditors of the Company.

             FOR                  AGAINST                 ABSTAIN

             / /                    / /                     / /


3.   In their  discretion,  the proxies are  authorized  to vote upon such other
     business as may properly come before the meeting.

(Please date, sign as name appears at left, and return promptly. If the stock is
registered in the name of two or more persons, each should sign. When signing as
Corporate  Officer,  Partner,  Executor,  Administrator,  Trustee,  or Guardian,
please give full title.  Please note any change in your  address  alongside  the
address as it appears in the Proxy.

Dated: __________________________            ___________________________________
                                                          (Signature)


                                             ___________________________________
                                                          (Print Name)


SIGN, DATE AND RETURN PROXY CARD PROMPTLY USING THE ENCLOSED ENVELOPE.



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