HEMISPHERX BIOPHARMA INC
S-3, EX-5.1, 2000-10-18
DRUGS, PROPRIETARIES & DRUGGISTS' SUNDRIES
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               [LETTERHEAD OF SILVERMAN, COLLURA & CHERNIS, P.C.]

                                          October 17, 2000

Hemispherx Biopharma, Inc.
1617 JFK Boulevard
Philadelphia, Pennsylvania 19103

      Re:   Registration Statement on Form S-3

Gentlemen:

      We have acted as counsel to Hemispherx Biopharma,  Inc. (the "Company"), a
Delaware corporation,  pursuant to Registration  Statement on Form S-3, as filed
with  the  Securities   and  Exchange   Commission  on  October  17,  2000  (the
"Registration  Statement"),  covering; (i) 755,000 shares issuable upon exercise
of our warrants; and (ii) 500,000 shares of our common stock.

      In acting as counsel  for the  Company  and  arriving  at the  opinions as
expressed below, we have examined and relied upon originals or copies, certified
or otherwise  identified  to our  satisfaction,  of such records of the Company,
agreements and other instruments,  certificates of officers and  representatives
of the Company,  certificates of public officials and other documents as we have
deemed necessary or appropriate as a basis for the opinions expressed herein.

      In connection  with our examination we have assumed the genuineness of all
signatures,  the authenticity of all documents tendered to us as originals,  the
legal capacity of natural  persons and the  conformity to original  documents of
all documents submitted to us as certified or photostated copies.

      Based on the foregoing,  and subject to the qualifications and limitations
set forth herein, it is our opinion that:
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            1. The Company has authority to issue the Common Stock in the manner
and under the terms set forth in the Registration Statement.

            2. The  Common  Stock  has been  duly  authorized  and when  issued,
delivered  and paid for in  accordance  with  their  respective  terms,  will be
validly issued, fully paid and non-assessable.

      We  express no  opinion  with  respect to the laws other than those of the
State of New York and  federal  laws of the  United  States of  America,  and we
assume no responsibility as to the applicability thereto, or the effect thereon,
of the laws of any other jurisdiction.

      We hereby  consent  to the filing of this  opinion  as Exhibit  5.1 to the
Registration Statement and its use as part of the Registration Statement.

      We are  furnishing  this opinion to the Company  solely for its benefit in
connection with the Registration  Statement.  It is not to be used,  circulated,
quoted or otherwise  referred to for any other purpose.  Other than the Company,
no one is entitled to rely on this opinion.

                                          Very truly yours,

                                          SILVERMAN, COLLURA, &, CHERNIS, P.C.



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