SAFESCIENCE INC
NT 10-K, 2000-03-31
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                          UNITED STATES
                SECURITIES AND EXCHANGE COMMISSION
                     Washington, D.C.   20549

                           FORM 12b-25

                   NOTIFICATION OF LATE FILING

[ x ] Form 10-K   [ ] Form 20-F   [ ] Form 11-K   [   ] Form 10-Q

For the period ended December 31, 1999.

     [ ] Transition Report on Form 10-K.
     [ ] Transition Report on Form 20-F.
     [ ] Transition Report on Form 11-K.
     [ ] Transition Report on Form 10-Q.
     For the Transition Period Ended:

If the notification relates to a portion of the filing checked
above, identify the Item(s) to which the notification relates:

PART I - REGISTRANT INFORMATION

                        SAFESCIENCE, INC.
                     Full Name of Registrant

                        File No. 33-021238

                        Park Square Building
                  31 St. James Avenue, Eight Floor
                     Boston, Massachusetts 02116
 _________________________________________________________________
          Address of principal executive office, including zip.

PART II - RULES 12B-25 and (c)

If the subject report could not be filed without unreasonable
effort or expense and the registrant seeks relief pursuant to
Rule 12b-25, the following should be completed.

               (a)  The reasons described in reasonable detail in
                    Part III of this form could not be eliminated
                    without unreasonable effort or expense;
[ X ]          (b)  The subject annual report, semi-annual
                    report, transition report of Form 10-K, Form
                    20-F, 11K or Form N-SAR, or portion thereof,
                    will be filed on or before the fifteenth
                    calendar day following the prescribed due
                    date; or the subject quarterly report of
                    transition report on Form 10-Q, or portion
                    thereof will be filed on or before the fifth
                    calendar day following the prescribed due
                    date; and


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               (c)  The accountant's statement or other exhibit
                    required by Rule 12b-25(c) has been attached
                    if applicable.

PART III - NARRATIVE

The Registrant is unable to complete the financial statements
within the prescribed period.

PART IV - OTHER INFORMATION

1.   Name and telephone number of person to contact in regard to
     this notification.

     Bradley J. Carver
     SafeScience, Inc.
     31 St. James Avenue, Eight Floor
     Boston, Massachusetts   02116
     (617) 422-0674

2.   Have all other periodic reports required under Section 13 or
     15(d) of the Securities Exchange Act of 1934 or Section 30
     of the Investment Company Act of 1940 during the preceding
     12 months (or for such shorter) period that the registrant
     was required to file such reports) been filed?  If answer is
     no, identify reports.

                    Yes x               No

3.   Is its anticipated that any significant change in results of
     operations from the corresponding period for the last fiscal
     year will be reflected by the earnings statements to be
     included in the subject report or portion thereof?

                    Yes                 No x

     If so, attach an explanation of the anticipated change, both
     narratively and quantitatively, and, if appropriate, state
     the reasons why a reasonable estimate of the results cannot
     be made.


SafeScience, Inc. has caused this notification to signed on its behalf
by the undersigned hereunto duly authorized, on this 30th day of March,
2000.

                              SAFESCIENCE, INC.


                              BY: /s/ Bradley J. Carver
                                  Bradley J. Carver, President,
                                  Chief Operating Officer and member
                                  of the Board of Directors




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