SAFESCIENCE INC
DEF 14A, 2000-03-28
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                               (Amendment No.   )
Filed by the Registrant  [X ]

Filed by a Party other than the Registrant  [  ]

Check the appropriate box:

[  ]  Preliminary Proxy Statement

[  ]  Confidential, for Use of the Commission Only (as permitted by Rule 14a-
      6(e)(2))

[X ]  Definitive Proxy Statement

[  ]  Definitive Additional Materials

[  ]  Soliciting Material Pursuant to Sections 240.14a-11(c) or Section 240.14a-
      12

                                SAFESCIENCE, INC.
                (Name of Registrant as Specified In Its Charter)


    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[ X]  No fee required

[  ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11

   1) Title of each class of securities to which transaction applies:


   2) Aggregate number of securities to which transaction applies:


   3) Per unit price or other underlying value of transaction computed pursuant
      to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is
      calculated and state how it was determined):


   4) Proposed maximum aggregate value of transaction:


   5) Total fee paid:


[  ]  Fee paid previously with preliminary materials

[  ]  Check box if any part of the fee is offset as provided by Exchange Act
      Rule 0-11(a)(2) and identify the filing for which the offsetting fee was
      paid previously.  Identify the previous filing by registration statement
      number, or the Form or Schedule and the date of its filing.

   1) Amount Previously Paid:


   2) Form, Schedule or Registration Statement No.:


   3) Filing Party:

   4) Date Filed:

<PAGE>



                                      PROXY

                                     FOR THE

                         ANNUAL MEETING OF STOCKHOLDERS

                                SAFESCIENCE, INC.

                                  June 29, 1999

_________________________________________ }
                                           Name(s) of Stockholder(s)
_________________________________________ }

This Proxy is solicited by the Board of Directors.

The undersigned  hereby appoints B. David Sandberg,  counsel to the Company,  as
proxy with  power of  substitution  to vote the shares of stock of  SAFESCIENCE,
INC.  which  the  undersigned  is  entitled  to vote at the  Annual  Meeting  of
Stockholders  to be held  on June  29,  1999 at I p.m.,  and at any  adjournment
thereof, as follows:

1.   Election of Directors    ___    For all nominees (except as
                                     marked below to the contrary:)
                                     Bradley J. Carver __
                                     David Platt __
                                     David Dube __
                                     Richard A. Salter __
                                     Theodore J. Host __
                                     Brian G.R. Hughes __
                              ___    Withhold authority to vote for all nominees
2.   Selection of Auditors    ___    For selection of Arthur Andersen LLP as
                                     independent auditors for 1999
                              ___    Withhold such approval
3.   Amendment of Articles    ___    For approval of amendment of the Company's
                                     Articles of Incorporation to increase
                                     authorized common shares from
                                     25,000,000 to 100,000,000
                              ___    Withhold such approval

THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR QUESTIONS 1, 2 AND 3 LISTED ABOVE.

In his  discretion,  the proxy is authorized to vote upon such other business as
may lawfully come before the meeting. The undersigned hereby revokes any proxies
as to said shares  heretofore  give by the undersigned and ratifies and confirms
all that said proxy may do by virtue hereof.

When this Proxy is properly executed, the shares to which the Proxy relates will
be voted as specified,  and if no other specification is made, will be voted for
all nominees for Directors,  for selection of Arthur Andersen LLP as independent
auditors.  It is understood that this Proxy confers  discretionary  authority in
respect of matters not known or  determined at the time of mailing of the Notice
of Annual Meeting of Stockholders to the undersigned.  The proxy intends to vote
the shares  represented by this Proxy on such matters,  if any, as determined by
the Board of Directors.

The undersigned hereby  acknowledges  receipt of the Notice of Annual Meeting of
Stockholders furnished herewith.

Dated and signed: _________________1999

                                      ------------------------------------------

                                      ------------------------------------------
                                      [NOTE: These signature(s) should agree
                                       exactly  with the name(s)  printed at the
                                       beginning   of  this  Proxy.   Executors,
                                       administrators,  trustees,  guardians and
                                       attorneys   should   so   indicate   when
                                       signing]

THE GIVING OF A PROXY WILL NOT AFFECT YOUR RIGHT TO VOTE IN PERSON IF YOU ATTEND
THE MEETING.


<PAGE>


                                SAFESCIENCE, INC.

                         31 ST. JAMES AVENUE, SUITE 520
                                BOSTON, MA 02116
                                 (617) 422-0674

                  NOTICE OF 1999 ANNUAL MEETING OF STOCKHOLDERS

                           TO BE HELD ON JUNE 29, 1999

         Notice is hereby  given that the  Annual  Meeting  of  Stockholders  of
SafeScience,  Inc.  (the  "Company")  will be held at the Park Plaza  Hotel,  64
Arlington Street, Boston, Massachusetts, on Tuesday, June 29, 1999 at I p.m.
Eastern daylight time.

         The Annual Meeting will be held for the following purposes:

                  1. Election of Directors. Election of directors of the Company
         by holders of Common Stock.

                  2.  Ratification of Auditors.  Ratification of the appointment
         of Arthur  Andersen LLP as auditors for the Company for the fiscal year
         ending December 31, 1999.

                  3.  Amendment  of  Articles.  For approval of amendment of the
         Company's  Articles  of  Incorporation  to  increase  the number of the
         Company's authorized common shares from 25,000,000 to 100,000,000.

                  4. Other  Business.  Such other  matters as may properly  come
         before the meeting or any adjournment thereof.

         Stockholders  of record at the close of  business  on May 18,  1999 are
entitled to notice of and to vote at the meeting or any adjournment thereof.

         We urge you to read the enclosed Proxy Statement  carefully so that you
may  be  informed  about  the  business  to  come  before  the  meeting,  or any
adjournment  thereof. At your earliest  convenience,  please sign and return the
accompanying proxy in the postage-paid envelope furnished for that purpose.

         A copy of our Annual Report for the fiscal year ended December 31, 1998
is enclosed.  The Annual Report is not a part of the proxy  soliciting  material
enclosed with this letter.

                                           By Order of the Board of Directors

                                           _____________________________________
Boston, Massachusetts                      David Platt, Chairman
May 31, 1999                               and Chief Executive Officer

         IT IS  IMPORTANT  THAT THE  PROXIES BE  RETURNED  PROMPTLY.  THEREFORE,
WHETHER OR NOT YOU PLAN TO BE PRESENT  IN PERSON AT THE ANNUAL  MEETING,  PLEASE
SIGN,  DATE AND  COMPLETE  THE  ENCLOSED  PROXY AND  RETURN  IT IN THE  ENCLOSED
ENVELOPE WHICH REQUIRES NO POSTAGE IF MAILED IN THE UNITED STATES.



<PAGE>


                                SAFESCIENCE, INC.

                         31 ST. JAMES AVENUE, SUITE 520
                                BOSTON, MA 02116
                                 (617) 422-0674

                                 PROXY STATEMENT

                                       FOR
                       1999 ANNUAL MEETING OF STOCKHOLDERS

                                  JUNE 29, 1999

         This Proxy Statement is being furnished to the holders of Common Stock,
$.01 par value  per share  (the  "Common  Stock"),  of  SafeScience,  Inc.  (the
"Company"), a Nevada corporation, in connection with the solicitation of proxies
by the Board of Directors of the Company to be voted at the 1999 Annual  Meeting
of Stockholders to be held at 1 p.m.,  Eastern  daylight time, on Tuesday,  June
29, 1999, at the Park Plaza Hotel, 64 Arlington Street,  Boston,  Massachusetts,
and at any  adjournment of such meeting.  This Proxy Statement is expected to be
mailed to stockholders on or about May 31, 1999.

         The proxy  solicited  hereby,  if properly  signed and  returned to the
Company and not revoked prior to its use,  will be voted in accordance  with the
instructions contained herein. If no contrary instructions are given, each proxy
received  will be voted for each of the matters  described  below and,  upon the
transaction of such other  business as may properly come before the meeting,  in
accordance with the best judgment of the persons appointed as proxies.

         Any  stockholder  giving a proxy has the power to revoke it at any time
before it is exercised by (i) filing with the  Secretary of the Company  written
notice  thereof  (31 St.  James  Avenue,  Suite 520,  Boston,  MA  02116),  (ii)
submitting a duly executed  proxy bearing a later date, or (iii) by appearing at
the Annual  Meeting and giving the  Secretary  notice of his or her intention to
vote in person.  Proxies  solicited  hereby may be exercised  only at the Annual
Meeting and any adjournment thereof and will not be used for any other meeting.

                 VOTING SECURITIES AND PRINCIPAL HOLDERS THEREOF

         Only  stockholders  of record at the close of  business on May 18, 1999
("Voting  Record Date") will be entitled to vote at the Annual  Meeting.  On the
Voting Record Date, there were 15,046,656  shares of the Common Stock issued and
outstanding.  Each share of Common  Stock is entitled to one vote on all matters
properly presented at the Annual Meeting.

         The  following  table  sets forth  certain  information  regarding  the
beneficial  ownership of the Common Stock as of the Voting  Record Date, by each
person  who is known by the  Company  to own  beneficially  more  than 5% of the
Company's  outstanding  securities.   Unless  otherwise  indicated,   the  named
beneficial  owner has sole  voting and  dispositive  power  with  respect to the
shares reported.



<PAGE>


                             Number of Shares of Common
Name, Stock, and Address    Stock Beneficially Owned at  Percentage Beneficially
of Beneficial Owner            Voting Record Date (1)             Owned (1)
- --------------------------------------------------------------------------------

David Platt (2)                   2,959,550                        19.7%
Bradley Carver (2)                2,557,686                        17.0%

(1)      The  Information  presented with respect to stock ownership and related
         percentage  information is based on Common Stock as a percentage of the
         aggregate number of shares of Common Stock  outstanding.  The number of
         shares of Common Stock outstanding, 15,046,656, does not include shares
         issuable upon exercise of warrants or certain outstanding stock options
         or shares  reserved for issuance  pursuant to the Company's  1996 Stock
         Option  Plan or its 1998  Stock  Option  Plan or shares  issuable  upon
         exercise of options which will become  exercisable  upon  attainment by
         the Company of certain pre-determined milestones.

(2)      The business address of Dr. Platt  and Mr. Carver  is c/o  SafeScience,
         Inc., 31 St. James Avenue, Suite 520, Boston, MA 02116.

                       PROPOSAL I - ELECTION OF DIRECTORS

         The Company's By-Laws provide that a plurality of the votes cast at the
Annual Meeting of stockholders  shall elect a Board of Directors.  Directors are
elected  for  one-year  terms  and  serve  until  the  next  annual  meeting  of
stockholders  and until  their  successors  are  elected or until  their  death,
resignation or removal.  Currently,  the Board of Directors has six members, all
of whom will be elected at the Annual  Meeting.  The  nominees  for director are
Bradley J. Carver,  David Dube,  Theodore J. Host, Brian G.R. Hughes,  Dr. David
Platt and Richard A. Salter.

         Unless  otherwise  directed,  each proxy  executed  and  returned  by a
stockholder  will be voted for the election of the nominees named above.  If any
person named as a nominee should be unable or unwilling to stand for election at
the time of the Annual  Meeting,  the proxy holders will nominate and vote for a
replacement  nominee  recommended  by the Board of Directors.  At this time, the
Board of Directors  knows of no reason why the nominees  listed above may not be
able to serve as directors if elected.

         The  following  table  sets forth  certain  information  regarding  the
nominees for election as a director  including  the number and percent of shares
of the Company's voting securities  beneficially owned by such persons as of the
Voting  Record Date. No nominee for director is related to any other nominee for
director or executive  officer of the Company by blood,  marriage,  or adoption,
and there are no  arrangements  or  understandings  between  any nominee and any
other person  pursuant to which such nominee was  selected.  The table also sets
forth the number of shares of the Company's voting securities beneficially owned
by each executive  officer of the Corporation and by all directors and executive
officers of the Company as a group.


<PAGE>


<TABLE>

                                                     NUMBER OF SHARES OF           PERCENTAGE
                                                     COMMON STOCK                  BENEFICIALLY
NAMES OF OFFICERS          DIRECTOR OF COMPANY       BENEFICIALLY OWNED AT         OWNED (1)
AND DIRECTORS              SINCE                     VOTING RECORD DATE

Director Nominees
- -----------------

<S>                                 <C>                      <C>                       <C>
David Platt                         1995                     2,959,550                 19.7%

Bradley Carver (2)                  1995                     2,557,686                 17.0%

David Dube (2)(3)                   1998                         8,000 (4)

Richard Salter                      1998                       253,300 (5)              1.7%

Theodore Host (3)                   1998                         8,000 (4)

Brian Hughes (2)(3)                 1998                        20,500 (4)

Other Executive
- ---------------
Officers
- --------

Richard Daoust                                                   2,500 (6)

All directors, executive
- ------------------------
officers and nominees
- ---------------------
for directors as a group
- ------------------------

(7 persons)                                                  5,803,536                 38.6%



Less than 1%.

(1)      The  information  presented with respect to stock ownership and related
         percentage  information is based on Common Stock as a percentage of the
         aggregate number of shares of Common Stock  outstanding.  The number of
         shares of Common Stock outstanding, 15,046,656, does not include shares
         issuable  upon  exercise of warrants  or of certain  outstanding  stock
         options or reserved for issuance  pursuant to the Company's  1996 Stock
         Option  Plan or its 1998  Stock  Option  Plan or shares  issuable  upon
         exercise of options which will become  exercisable  upon  attainment by
         the Company of certain pre-determined milestones.

(2)      Member of the Audit Committee.

(3)      Member of the Compensation Committee.

(4)      Includes  shares  issuable  upon the  exercise  of  options  which were
         granted to such  individual  upon  election  as a  director  which have
         vested  as of the  Voting  Record  Date or  will  vest  within  60 days
         thereafter.  Excludes  12,000  shares  issuable  upon the  exercise  of
         options to  purchase  Common  Stock  which will not vest within 60 days
         after the Voting Record Date.

(5)      Excludes  shares  issuable  upon the  exercise  of options to  purchase
         Common  Stock  which have not vested as of the  Voting  Record  Date or
         within  60 days  thereafter.  Such  options  vest at the  rate of 5,000
         shares per month until July, 1999. Mr. Salter's  contract also provides
         for the grant of additional  options upon the Company's  achievement of
         certain  milestones.  10,000  of such  options  have  vested  and  been
         exercised as of the Voting  Exercise Date. In addition,  such number of
         shares  excludes  100,000 shares  issuable upon the exercise of options
         that will vest in January, 2000.

(6)      Excludes  shares  issuable  upon the  exercise  of options to  purchase
         Common  Stock  which have not vested as of the  Voting  Record  Date or
         within 60 days thereafter.

</TABLE>

<PAGE>

         Dr.  Platt,  45, has been the Chief  Executive  Officer,  Secretary and
Chairman  of the  Board of  Directors  since  March  1995 and has been the Chief
Executive  Officer,  Secretary  and the  Chairman of the Board of  Directors  of
International Gene Group, Inc. ("IGG"),  the Company's  wholly-owned  subsidiary
for the  development  of human  therapeutics  since December 1992. Dr. Platt has
been Chief Executive  Officer,  Secretary and Chairman of the Board of Directors
of SafeScience  Products,  Inc., a wholly owned  subsidiary of the Company since
its inception on June 23, 1995. Dr. Platt received a Doctor of Philosophy degree
(1989),  Masters of Science degree (1983), and Bachelor of Science degree (1978)
from the Hebrew  University of Jerusalem,  Israel and a Bachelor of  Engineering
degree (1980) from Technion, Haifa, Israel.

         Mr. Carver, 37, has been President,  Chief Financial Officer, Treasurer
and a member of the Board of Directors  of the Company  since March 1995 and has
been the President, Chief Financial Officer, Treasurer and a member of the Board
of Directors of IGG since February 1993.  Mr. Carver has been  President,  Chief
Financial  Officer,  Treasurer  and a  member  of  the  Board  of  Directors  of
SafeScience  Products,  Inc., a wholly owned subsidiary of the Company since its
inception on June 23, 1995.  From June 1992 to October 1994, Mr. Carver has been
a consultant with Cyrowski and  Associates,  which is engaged in the business of
commercial  real estate.  From March 1991 to October 1994, Mr. Carver has been a
consultant  with  Circuit  Master,  Inc.,  a Michigan  corporation,  which is an
electronics design and engineering firm engaged in the production of audio power
amplifiers.  Mr. Carver  received a Bachelor of Arts degree in  management  from
Michigan State University in 1983.

         Mr. Dube,  42, has been a director of the Company since May,  1998. Mr.
Dube has been a Senior Vice  President,  Investment  Banking with RAS Securities
Corporation since March, 1998, specializing in early stage financings, strategic
financial  planning and  advisory  services  relating to mergers,  acquisitions,
capital  formation and  restructuring  for private and public  companies and was
previously, from September, 1997 to February, 1998, a project finance consultant
to the firm.  Mr. Dube has been the  President  and Chief  Executive  Officer of
Optimax  Industries,  Inc.,  a publicly  traded  company  with  interests in the
horticultural,  decorative  giftware and truck part accessories  industries from
July, 1996 to September,  1997. From February,  1991 to June, 1996, Mr. Dube had
been the  principal of Dube & Company,  a financial  consulting  firm.  Mr. Dube
serves on the boards of directors of publicly  traded  Helmstar  Group,  Inc., a
merchant  banking firm and  privately-held  Meyers  Capital  Management,  LLC, a
registered  investment  advisory firm. Mr. Dube is a Certified Public Accountant
in the state of New Hampshire.

         Mr. Salter, S6, has been a director of the Company since December, 1998
and the Company's  Executive Vice President since January,  1998. Prior thereto,
Mr. Salter was the Company's Vice President  -Corporate  Development  from June,
1997 through  January,  1998 and served the Company as a  consultant  from June,
1996 through  July,  1997.  Prior  thereto,  from 1989  through 1996 Mr.  Salter
rendered consulting services in the areas of sales and marketing to a variety of
small businesses and companies. From 1971 to 1989, Mr. Salter was co-founder and
Senior Vice President of  International  Weekends,  a travel and leisure company
which was the most  profitable  charter  vacation  company in the United States,
with $250,000,000 in annual revenues and 600 employees. Mr. Salter is a graduate
of the Boston University School of Law.

         Mr. Host, 53, has been a director of the Company since December,  1998.
From 1991 through 1996 Mr. Host was the President and Chief  Operating  Officer,
and later Chief Executive  Officer,  of The Scotts Company.  Prior thereto,  Mr.
Host was Senior  Vice  President  -  Marketing  for  Coca-Cola,  USA in Atlanta,
Georgia  from 1990 to 1991.  From 1967  through  1990 Mr. Host held a variety of
positions with American Home Products,  a $14 billion company involved primarily
in the health care industry.

         Mr.  Hughes,  44, has been a director  of the Company  since  December,
1998. Mr. Hughes is president-select of the Association of Alumni and Alumnae of
the Massachusetts  Institute of Technology (MIT). Since 1978 Mr. Hughes has held
a variety of positions  with the MIT  Corporation,  the board which governs MIT.
From 1989  through  1995 Mr.  Hughes was Vice  Chairman and then CEO of American
Rocket Company,  which worked to develop and commercialize safe, clean, low cost
hybrid  rocket  propulsion.  Prior  thereto,  from  1984  through  1989,  he was
co-founder and Executive  Vice  President of PTAT System Inc.,  which co-built a
private,  transatlantic  fiber optic cable system.  PTAT System Inc. was sold to
Sprint in August,  1989.  Prior  thereto,  from 1982 through 1984 Mr. Hughes was
Senior Vice President of U.S. Aviation Underwriters, Inc. in Washington, DC.

         Dr.  Daoust joined the Company as its Vice  President - Agriculture  in
February,  1999.  From 1997 to 1999 Dr. Daoust was the cofounder of BioSolutions
International,  Inc., a start-up biotechnology company. Prior thereto, from 1985
through  1997,  Dr.  Daoust held a variety of  positions  with Ecogen  Inc.,  an
agricultural  biotechnology  company specializing in the development and sale of
naturally-occurring and genetically modified biologically-based pesticides. Such
positions  included  Director for  International  Marketing and Distribution and
General  Manager of Ecogen  Europe.  Prior  thereto,  from 1978 through 1985 Dr.
Daoust was a  research  scientist,  host-country  coordinator  and  postdoctoral
research fellow at the Boyce Thompson Institute at Cornell University in Ithaca,
New York and in Goias, Brazil.


<PAGE>

MEETINGS AND COMMITTEES OF THE BOARD OF DIRECTORS

         During the fiscal year ended  December 31, 1998, the Board of Directors
of the Company  met once in addition to taking a number of actions by  unanimous
written consent.  During fiscal year 1998, no incumbent  director of the Company
attended fewer than 85% of the aggregate of the total number of Board  meetings.
The Board has an Audit  Committee,  consisting of Mr.  Carver,  Mr. Dube and Mr.
Hughes.  The Audit  Committee held no meetings during 1998. The board also has a
Compensation  Committee,  consisting of Mr. Dube, Mr. Host and Mr.  Hughes.  The
Compensation Committee held no meetings during 1998.

DIRECTOR COMPENSATION

         Directors  who  are  not  also  employees  of  the  Company  receive  a
non-qualified option to purchase 20,000 shares of Common Stock, which vests over
two  consecutive  one-year  terms.  Such options vest and become  exercisable as
follows:  Options to purchase  4,000 shares become  exercisable  at the time the
optionee becomes a director;  and options to purchase an additional 2,000 shares
become  exercisable at the end of each full calendar quarter  thereafter.  After
the expiration of such two one-year terms,  each director may be granted options
to purchase  additional shares for subsequent  periods of service.  The exercise
price with  respect to all  options  granted to  directors  will be the  average
closing bid price of the Common  Stock  during the twenty  trading days prior to
the date of grant.  Such options will be  exercisable  for a period of ten years
from the date of grant.  All  vesting of options  will cease at such time as any
optionee ceases to be a non-employee director of the Company for any reason, and
any options  theretofore  granted  which have not vested will be  cancelled  and
forfeited to the Company.

         THE DIRECTORS  WILL BE ELECTED UPON RECEIPT OF A PLURALITY OF ALL VOTES
CAST BY HOLDERS OF COMMON STOCK AT THE ANNUAL STOCKHOLDERS MEETING.



<PAGE>


             PROPOSAL 11 -- RATIFICATION OF APPOINTMENT OF AUDITORS

         The Board of Directors  recommends the ratification by the stockholders
at the Annual Meeting of the  appointment of Arthur  Andersen LLP as independent
auditors for the fiscal year ended December 31, 1999. A representative of Arthur
Andersen  LLP  is  expected  to be  present  at  the  Annual  Meeting  with  the
opportunity to make a statement if he or she so desires.  He or she will also be
available to respond to any appropriate questions stockholders may have.

         RATIFICATION  OF THE  APPOINTMENT  OF AUDITORS  REQUIRES THAT THE VOTES
CAST (IN PERSON OR BY PROXY) AT THE ANNUAL MEETING OR AT ANY ADJOURNMENT THEREOF
IN FAVOR OF RATIFICATION EXCEED THOSE CAST AGAINST.

             PROPOSAL III -- AMENDMENT OF ARTICLES OF INCORPORATION

         The Company's  Articles of  Incorporation  (the  "Articles")  presently
provide that the  Company's  authorized  capital  stock  consists of  25,000,000
shares of Common Stock, of which 14,291,160 are issued and outstanding as of the
Voting Record Date, and 5,000,000  shares of Preferred  Stock, of which none are
issued and outstanding as of the Voting Record Date. The Board proposes to amend
the  Articles to increase the number of  authorized  shares of Common Stock from
25,000,000 to 100,000,000.

         The Board believes  that, as a result of the Company's  plans to expand
its sales and distribution  channels,  its commencement of Phase II FDA clinical
testing for its human therapeutic  product,  GBC-590,  its aggressive pursuit of
additional licensing and technology opportunities and its forecasted increase in
its general and administrative expenses, the Company will have cash requirements
during the upcoming  twelve to eighteen months which it may wish to meet through
the issuance of additional capital stock. While the Board has authority to issue
stock which is authorized, only the stockholders of the Company may increase the
Company's authorized capital.  Therefore, in order to be able to provide for the
Company's capital needs for the foreseeable  future, the Board has determined to
increase  the number of the  Company's  authorized  shares of Common  Stock from
25,000,000 to 100,000,000 shares. Such increase must be effected by an amendment
to the  Company's  Articles  of  Incorporation.  There  will be no change in the
number of authorized shares of Preferred Stock.

         The  Board  of  Directors  recommends  that the  Stockholders  vote for
amendment of the Articles.

         ADOPTION OF THE AMENDMENT REQUIRES THAT THE VOTES CAST (IN PERSON OR BY
PROXY) AT THE ANNUAL MEETING OR AT ANY ADJOURNMENT  THEREOF IN FAVOR OF ADOPTION
EXCEED THOSE CAST AGAINST.

                             EXECUTIVE COMPENSATION

         The following table sets forth the compensation  paid or accrued during
1998 and 1997 for services  rendered  during such period by the chief  executive
officer,  the president,  and the senior vice  president  (the "named  executive
officers"). No other executive officer of the Company had aggregate compensation
from the Company exceeding $100,000 in 1998.




<PAGE>


                               ANNUAL COMPENSATION

                       Position                     Year             Salary
                       --------                     ----             ------

           David Platt, Ph.D., Chairman and         1998            $119,000
              Chief Executive Officer               1997            $106,000

           Bradley Carver, President and            1997            $119,000
              Chief Financial Officer               1998            $104,000

           Richard A. Salter                        1998            $671,988 (1)
              Executive Vice President              1997            $139,781 (2)

(1)      Mr.  Salter's  salary was paid in the form of 190,000  shares of Common
         Stock of the Company valued at $671,988. Mr. Salter did not receive any
         cash compensation from the Company.

(2)      Mr.  Salter's  salary  was paid in the form of 30,000  shares of Common
         Stock of the Company valued at $139,781. Mr. Salter did not receive any
         cash compensation from the Company.  In addition,  prior to becoming an
         employee of the Company, he received 30,000 shares of Common Stock as a
         consultant  and exercised  options to purchase  57,500 shares of Common
         Stock at $0.01 per share which were  granted in 1996.  The value of the
         87,500 shares issued to Mr. Salter as a consultant  during 1997 totaled
         $281,938.

         Option Grant Table.  The following table set forth certain  information
regarding  options  granted during the year ended December 31, 1998 to the named
executive officers.

<TABLE>

                OPTION GRANTS DURING YEAR ENDED DECEMBER 31, 1998
<CAPTION>

                                       PERCENT OF
                                          TOTAL                                        POTENTIAL REALIZABLE
                       NUMBER OF         OPTIONS                                         VALUE AT ASSUMED
                      SECURITIES       GRANTED TO         EXERCISE                     ANNUAL RATES OF STOCK
                      UNDERLYING        EMPLOYEES          OR BASE                    PRICE APPRECIATION FOR
                        OPTIONS         IN FISCAL           PRICE      EXPIRATION           OPTION TERM (1)
NAME                  GRANTED (#)         YEAR             ($/SH.)        DATE            -----------------
- ----                  -----------        ------            -------       ------           5%($)      10%($)

<S>                     <C>              <C>              <C>            <C>           <C>          <C>
Richard A. Salter       300,000          81.98%           $0.01 (2)      1/2/03        $1,093,012   $1,348,963

(1)      These  columns  show the  hypothetical  gains or option  spreads of the
         options  granted  based on the fair market value of the Common Stock on
         the date of grant and assumed annual compound share  appreciation rates
         of 5% and 10% over the full term of the options.  The assumed  rates of
         appreciation are mandated by the SEC and do not represent the Company's
         estimate or projection of future share prices. Actual gains, if any, on
         option  exercises  will depend on the timing of such  exercise  and the
         future  performance  of the Common Stock.  Values are net of the option
         exercise  prices,  but do not  include  deductions  for  taxes or other
         expenses associated with the exercise.

(2)      The Common Stock  underlying  the options  granted to Mr.  Salter had a
         market  price of $3.50  per  share on the date of  grant;  because  the
         underlying   securities  were  "restricted   stock",   such  price  was
         discounted by 20% to reach a market value of $2.80 per share.

</TABLE>

         Year-end   Option  Table.   The  following   table  set  forth  certain
information  regarding options exercised during the year ended December 31, 1998
and  options  exercised  during the year ended  December  31,  1998 by the named
executive officers.

<TABLE>

               AGGREGATE OPTION EXERCISES AS OF DECEMBER 31, 1998
                           AND YEAR-END OPTION VALUES
<CAPTION>

                  NUMBER OF
                   SHARES                         NUMBER OF SECURITIES             VALUE OF UNEXERCISED
                  ACQUIRED          VALUE        UNDERLYING UNEXERCISED                IN THE MONEY
                     ON           REALIZED     OPTIONS AT FISCAL YEAR-END     OPTIONS AT FISCAL YEAR-END (2)
NAME              EXERCISE         ($)(1)       EXERCISABLE UNEXERCISABLE       EXERCISABLE  UNEXERCISABLE
- ----              --------        --------      ----------- -------------       -----------  -------------

<S>                <C>            <C>                <C>      <C>                    <C>        <C>
Richard A. Salter  190,000        $671,988           0        200,000                0          $800,000

(1)      The values in this column  represent the reported  low/bid price (less,
         in the case of options to purchase  "restricted stock", a 20% discount)
         on the  respective  dates  of  exercise,  less  the  respective  option
         exercise prices.

(2)      Value is based on the low/bid price  (discounted  by 20%) of the Common
         Stock on December 31, 1998  ($5.00),  the last trading of the Company's
         1998 fiscal year, less the applicable option exercise price.

</TABLE>


CERTAIN TRANSACTIONS WITH MANAGEMENT AND STOCKHOLDERS

         During 1998,  the Company issued  1,560,163  shares of Common Stock for
cash  consideration  of $5,729,892 less associated  expenses of $198,420.  These
shares include 181,818 shares issued pursuant to an offering under  Regulation S
for a total purchase price of $500,000. Also included in this amount are 146,000
shares  sold in the  first  half of 1998,  for an  aggregate  purchase  price of
$438,000,  in a private  placement  commenced in the fall of 1997, which private
placement  resulted in the issuance of a total (during 1997 and 1998) of 679,867
shares of Common Stock for total  consideration of $2,039,601,  before expenses.
The stock  offered in the  1997-1998  private  placement  has warrants  attached
allowing the purchaser to purchase one additional share, for a purchase price of
$4.75, for every four shares purchased. All such warrants expire five years from
the date of issue,  or earlier in the event the  market  price of the  Company's
Common Stock reaches and remains at $11.00 for thirty consecutive  trading days.
Also included in this amount are 406,206  shares sold in a private  placement in
the third quarter of 1998, for an aggregate  purchase  price of  $1,625,176;  an
additional  646,918  shares sold in a private  placement in the end of the third
and the beginning of the fourth quarter of 1998, for an aggregate purchase price
of  $2,161,744;  and 179,222  shares sold in a private  placement  commenced  in
December 1998, for an aggregate purchase price of $806,500.

         In January,  1998, the Company  amended its  employment  agreement with
Richard  Salter to grant Mr.  Salter  the title of  Senior  Vice  President.  In
connection with such  amendment,  the Company agreed to issue Mr. Salter options
to purchase up to 300,000  shares of Common Stock for a purchase  price of $0.01
per share. Such options have a term of ten years and vest and become exercisable
in equal  installments  of 100,000  shares each on the first business day of the
years 1998,  1999 and 2000,  provided  that Mr.  Salter is then  employed by the
Company  in a position  of Senior  Vice  President  or a  substantially  similar
position. All such options are in addition to those which Mr. Salter is entitled
to receive under the terms of his  employment  contract with the Company,  which
provides that at the  conclusion  of each month of employment  with the Company,
until July, 1999, Mr. Salter shall be issued  non-qualified  options to purchase
5,000  Shares,  of which 2,500  Shares  shall be  "unrestricted"  stock which is
registered  pursuant to the Company's  registration on Form S-8, and the balance
of 2,500 Shares shall be "restricted" stock which is not so registered. The term
of such  options is also ten years and they bear an exercise  price of $0.01 per
share.  In addition,  pursuant to an agreement  with the Company,  Mr. Salter is
entitled to receive additional options upon the occurrence of certain events. As
of the  Voting  Record  Date,  10,000  of such  options  have  vested  and  been
exercised.



<PAGE>


         The  following   graph   compares  the   cumulative   total  return  to
shareholders  of Common  Stock of the Company  from  September  30, 1995 through
December  31, 1998 to  cumulative  total return of the NASDAQ Stock Market Index
and the NASDAQ  Pharmaceutical  index for the same  period of time.  The Company
does  not  believe  any  other  published  industry  of  line-of-business  index
adequately  represents  the  current  operations  of the  Company or that it can
identify a peer group that merits comparison. The graph assumes $100 is invested
in the  Company's  stock and in each of the two  indexes at the  closing  market
quotations  on  September  30,  1995  and that  dividends  are  reinvested.  The
performances  shown on the graph are not necessarily  indicative of future price
performance.



                                     [GRAPH]



                                9/95      12/95      12/96      12/97      12/98

SAFESCIENCE, INC.               $100       $215       $169       $223       $323
NASDAQ STOCK MARKET (U.S.)      $100       $101       $124       $152       $215
NASDAQ PHARMACEUTICAL           $100       $117       $117       $121       $154


<PAGE>


                              STOCKHOLDER PROPOSALS

         Any proposal  that a stockholder  wishes to have  presented at the next
Annual  Meeting  of the  Company  anticipated  to be held in June  2000  must be
received at the main office of the Company for inclusion in the proxy  statement
no later than 120 days in advance of April 30, 2000.  Any such proposal shall be
sent to the  attention of the  Secretary of the Company at 31 St. James  Avenue,
Suite 520, Boston, MA 02116.

                   FILINGS UNDER SECTION 16(A) OF THE 1934 ACT

         Section I 6(a) of the  Securities  Exchange  Act of 1934,  as  amended,
requires that the Company's officers and directors and persons who own more than
10% of the  Company's  Common  Stock file  reports of  ownership  and changes in
ownership  with the Securities and Exchange  Commission  (the "SEC").  Officers,
directors and greater than 10%  stockholders  are required by SEC  regulation to
furnish the Company with copies of all Section I 6(a) forms that they file.

         Based solely on its review of the copies of such forms  received by it,
and/or written  representations  from certain  reporting persons that no Forms 5
were  required for those  persons,  the Company  believes that during the fiscal
year ended  December 31, 1998, all forms  applicable to its officers,  directors
and greater than 10% beneficial owners with respect to Section 16(a) of the 1934
Act were filed.

                                  OTHER MATTERS

         The Board of  Directors is not aware of any business to come before the
Annual  Meeting  other  than those  matters  described  in the Proxy  Statement.
However, if any other matters should properly come before the Annual Meeting, it
is intended  that the  proxies  solicited  hereby will be voted with  respect to
those other  matters in accordance  with the judgment of the persons  voting the
proxies.

         The cost of solicitation  of proxies will be borne by the Company.  The
Company  will  reimburse  brokerage  firms and other  custodians,  nominees  and
fiduciaries for reasonable  expenses  incurred by them in sending proxy material
to the beneficial  owners of the Common Stock.  In addition to  solicitation  by
mail,  directors,  officers,  and  employees of the Company may solicit  proxies
personally or by telephone without additional compensation.

         Each  stockholder  is urged to  complete,  date and sign the  proxy and
return it promptly in the enclosed return envelope.

         Insofar  as any of the  information  in the  Proxy  Statement  may rest
peculiarly  within the knowledge of persons other than the Company,  the Company
relies upon  information  furnished by others for the accuracy and  completeness
thereof.

                                            By Order of the Board of Directors,


                                            /s/ David Plattw
                                            ------------------------------------
                                            David Platt, Chairman
                                            and Chief Executive Officer
May 31, 1999



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