SAFESCIENCE INC
8-K, 2000-04-07
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported): March 29, 2000

                             ----------------------

                         COMMISSION FILE NUMBER 0-26476

NEVADA                                SAFESCIENCE, INC.           33-0231238
(State of other                 (Exact name of registrant as   (I.R.S. Employer
jurisdiction of incorporation   specified in its charter)    Identification No.)
or organization)

                31 St. James Avenue, Boston, Massachusetts 02116
     ------------------------------------------------------ ---------------
              (Address of principal executive officers) (Zip Code)

        Registrant's telephone number, including area code (617) 422-0674
                             ----------------------

                                 Not Applicable
         --------------------------------------------------------------
          (Former name or former address, if changed since last report)



<PAGE>


ITEM 5.           OTHER EVENTS

         On March 30, 2000, SafeScience, Inc. (the "Company") closed a private
placement whereby it raised $5,000,000 through the sale to Strong River
Investments, Inc. and Montrose Investments Ltd. of an aggregate of 346,021
shares of its common stock at $14.45 per share, warrants to purchase 108,996
additional shares of common stock at $15.98 per share exercisable for five years
(the "Closing Warrants"), and warrants to purchase shares of common stock at
$0.01 per share exercisable for five years, the number of shares to be
determined in the future according to a formula based on the then price per
share compared to the $14.45 common stock offering price (the "Adjustable
Warrants"). The purchasers have certain rights including, but not limited, to
registration rights, rights-of-first-refusal, and adjustments for certain
events. Net proceeds from the offering were $4,625,000. The purchasers have
committed to purchase an additional 138,408 shares of the Company's common stock
also at $14.45 per share for an aggregate of $2,000,000 upon the date at which
the registration statement for the initial shares becomes effective, provided
the date is no later than June 29, 2000. In addition, the purchasers have
committed to purchase $7,000,000 additional shares at the price equal to the
lesser of (i) 110% of the average of the closing bid prices of the Company's
common stock for the four trading days preceding the closing date of the tranche
and (ii) $16.00, with additional similar warrants (the "Additional Closing
Warrants" and "Additional Adjustable Warrants") within 190-210 days from the
closing of the initial transaction subject to certain conditions including, but
not limited to, certain market capitalization, trading volume, and share price
thresholds. The Additional Closing Warrants will enable each investor to
purchase 7.5% of the number of shares issued to it at the additional closing.

         The above summary of the private placement is not intended to be
complete and is qualified in its entirety by reference to the detailed
provisions in the agreements which are attached as Exhibits. In addition, a copy
of the press release issued by the Company in connection with the above-stated
transaction is attached hereto as Exhibit 99.1 to this Form 8-K and is
incorporated herein by reference.

ITEM 7.           FINANCIAL STATEMENTS AND EXHIBITS

(c)      Exhibits

Exhibit Number                              Description
- --------------                              -----------
     10.1                  Securities Purchase Agreement by and among
                           SafeScience, Inc., Strong River Investments, Inc. and
                           Montrose Investment Ltd. dated March 29, 2000.

     10.2                  Form of Closing Warrant dated March 29, 2000.

     10.3                  Form of Adjustable Warrant dated March 29, 2000.

     10.4                  Registration Rights Agreement by and among
                           SafeScience, Inc., Strong River Investments, Inc. and
                           Montrose Investments, Inc. dated March 29, 2000.

     10.5                  Letter Agreement by and among SafeScience, Inc.,
                           Strong River Investments, Inc. and Montrose
                           Investments Ltd. dated March 29, 2000.

     99.1                  Press Release dated March 31, 2000 issued by the
                           Company.


                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.


Dated:  April 7, 2000                 By:   /s/ Bradley J. Carver
                                         ____________________________________
                                            Bradley J. Carver
                                            President



















                          SECURITIES PURCHASE AGREEMENT

                                      among

                                SAFESCIENCE, INC.

                                       and

                         THE INVESTORS SIGNATORY HERETO




                           Dated as of March 29, 2000

<PAGE>


                                TABLE OF CONTENTS

                                                                            PAGE




ARTICLE I         PURCHASE AND SALE............................................1

         1.1               The Closing.........................................1

ARTICLE II        REPRESENTATIONS AND WARRANTIES...............................2

         2.1               Representations and Warranties of the Company.......2

         2.2               Representations and Warranties of the Purchasers...10

ARTICLE III       OTHER AGREEMENTS OF THE PARTIES.............................12

         3.1               Transfer Restrictions..............................12

         3.2               Acknowledgment of Dilution.........................13

         3.3               Furnishing of Information..........................14

         3.4               Integration........................................14

         3.5               Increase in Authorized Shares......................14

         3.6               Reservation and Listing of Underlying Shares.......15

         3.7               Exercise Procedures................................15

         3.8               Right of First Refusal; Subsequent Registrations...15

         3.9               Certain Securities Laws Disclosures; Publicity.....17

         3.10              Use of Proceeds....................................17

         3.11              Reimbursement......................................18

         3.12              Exchange Act Registration..........................18

         3.13              Corporate Existence................................18

         3.14              Dividends and Distributions........................19

ARTICLE IV        MISCELLANEOUS...............................................19

         4.1               Fees and Expenses..................................19

         4.2               Entire Agreement; Amendments.......................19

         4.3               Notices............................................19

         4.4               Amendments; Waivers................................20

         4.5               Headings...........................................20

         4.6               Successors and Assigns.............................20

         4.7               No Third-Party Beneficiaries.......................20

         4.8               Governing Law......................................21

         4.9               Survival...........................................21

<PAGE>

                               TABLE OF CONTENTS
                                  (continued)


         4.10              Execution..........................................21

         4.11              Severability.......................................21

         4.12              Remedies...........................................21

         4.13              Independent Nature of Purchasers' Obligations
                                      and Rights.............................22




<PAGE>





     SECURITIES  PURCHASE  AGREEMENT (this  "Agreement"),  dated as of March 29,
2000, among  SafeScience,  Inc., a Nevada  corporation (the "Company"),  and the
investors  signatory  hereto (each such investor is a  "Purchaser"  and all such
investors are, collectively, the "Purchasers").

     WHEREAS, subject to the terms and conditions set forth in this
Agreement, the Company desires to issue and sell to the Purchasers and the
Purchasers, severally and not jointly, desire to purchase from the Company,
shares of the Company's common stock, $.01 par value per share (the "Common
Stock"), and certain other securities of the Company as more fully described in
this Agreement.

     NOW, THEREFORE,  IN CONSIDERATION of the mutual covenants contained in this
Agreement,  and for  other  good and  valuable  consideration  the  receipt  and
adequacy  are hereby  acknowledged,  the  Company  and the  Purchasers  agree as
follows:

                                   ARTICLE I
                                PURCHASE AND SALE

     1.1 The Closing.

         (a) The Closing. (i) Subject to the terms and conditions set forth in
this Agreement, the Company shall issue and sell to the Purchasers and the
Purchasers shall, severally and not jointly, purchase an aggregate of 484,429
shares of Common Stock (the "Shares") for an aggregate purchase price of
$7,000,000. The closing of the purchase and sale of the Shares (the "Closing")
shall take place at the offices of Robinson Silverman Pearce Aronsohn & Berman
LLP ("Robinson Silverman"), 1290 Avenue of the Americas, New York, New York
10104, immediately following the execution hereof or such later date as the
parties shall agree. The date of the Closing is hereinafter referred to as the
"Closing Date."

              (ii) At the Closing, the parties shall deliver or shall cause to
be delivered the following: (A) the Company shall deliver to each Purchaser (1)
a stock certificate representing 5/7th of the number of Shares indicated below
such Purchaser's name on the signature page of this Agreement, registered in the
name of such Purchaser, (2) a Common Stock purchase warrant, in the form of
Exhibit A, registered in the name of such Purchaser, pursuant to which such
Purchaser shall have the right to acquire shares of Common Stock upon the terms
and in such number as set forth therein (each an "Adjustable Warrant"), (3) a
Common Stock purchase warrant, in the form of Exhibit B, registered in the name
of such Purchaser, pursuant to which such Purchaser shall have the right to
acquire the number of shares of Common Stock indicated below such Purchaser's
name on the signature page of this Agreement, upon the terms and at the exercise
price set forth therein (each, a "Closing Warrant" and together with the
Adjustable Warrants, the "Warrants"), (4) the legal opinion of McDermott, Will &
Emery, outside counsel to the Company, substantially in the form of Exhibit C,
(5) an executed Registration Rights Agreement, dated the date hereof, among the
Company and the Purchasers, in the form of Exhibit D (the "Registration Rights
Agreement"), (6) the Transfer Agent Instructions, in the form of Exhibit E,
executed by the Company and



<PAGE>

delivered to and acknowledged by the Company's transfer agent (the "Transfer
Agent Instructions") and (7) an executed Letter Agreement, dated the date
hereof, among the Company and the Purchasers, in the form of Exhibit G (the
"Letter Agreement"); and (B) each Purchaser shall deliver (1) 5/7th of the
purchase price indicated below such Purchaser's name on the signature page to
this Agreement in United States dollars in immediately available funds by wire
transfer to an account designated in writing by the Company for such purpose and
(2) an executed Registration Rights Agreement and Letter Agreement.

              (iii) If the Effective Date (as defined in Section 3.1(b)) occurs
on or prior to the 90th day following the Closing Date, then on the second (2nd)
Trading Day following the Effective Date, (A) the Company will, against delivery
of the amounts set forth in clause (B) in this paragraph, deliver to each
Purchaser, a stock certificate representing 2/7th of the number of Shares
indicated below such Purchaser's name on the signature page of this Agreement
(subject to equitable adjustment for stock splits, recombinations and similar
events), registered in the name of such Purchaser, and (B) each Purchaser will
deliver to the Company, 2/7th of the purchase price indicated below such
Purchaser's name on the signature page to this Agreement in United States
dollars in immediately available funds by wire transfer to an account designated
in writing by the Company for such purpose.

         1.2 Certain Defined Terms. For purposes of this Agreement, "Trading
Day" and "Per Share Market Value" shall have the meanings set forth in the
Adjustable Warrant and "Business Day" shall mean any day except Saturday, Sunday
and any day which shall be a federal legal holiday or a day on which banking
institutions in the State of New York or the Commonwealth of Massachusetts
generally are authorized or required by law or other governmental action to
close. A "Person" means an individual or corporation, partnership, trust,
incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof)
or other entity of any kind.

                                   ARTICLE II
                         REPRESENTATIONS AND WARRANTIES

         2.1 Representations and Warranties of the Company. The Company hereby
makes the following representations and warranties to the Purchasers:

              (a) Organization and Qualification. The Company is a corporation
duly organized, validly existing and in good standing under the laws of the
State of Nevada, with the requisite corporate power and authority to own and use
its properties and assets and to carry on its business as currently conducted.
The Company has no subsidiaries other than as set forth in Schedule 2.1(a)
(collectively, the "Subsidiaries"). Each of the Subsidiaries is an entity, duly
organized, validly existing and in good standing under the laws of the
jurisdiction of its incorporation or organization (as applicable), with the
requisite power and authority to own and use its


<PAGE>

properties and assets and to carry on its business as currently conducted. Each
of the Company and the Subsidiaries is duly qualified to do business and is in
good standing as a foreign corporation or other entity in each jurisdiction in
which the nature of the business conducted or property owned by it makes such
qualification necessary, except where the failure to be so qualified or in good
standing, as the case may be, could not, individually or in the aggregate, (x)
adversely affect the legality, validity or enforceability of the Securities (as
defined below) or any of this Agreement, the Registration Rights Agreement, the
Transfer Agent Instructions, the Letter Agreement or the Warrants (collectively,
the "Transaction Documents"), (y) have or result in a material adverse effect on
the results of operations, assets, prospects, or condition (financial or
otherwise) of the Company and the Subsidiaries, taken as a whole, or (z)
adversely impair the Company's ability to perform fully on a timely basis its
obligations under any of the Transaction Documents (any of (x), (y) or (z), a
"Material Adverse Effect").

              (b) Authorization; Enforcement. The Company has the requisite
corporate power and authority to enter into and to consummate the transactions
contemplated by each of the Transaction Documents and otherwise to carry out its
obligations thereunder. The execution and delivery of each of the Transaction
Documents by the Company and the consummation by it of the transactions
contemplated thereby have been duly authorized by all necessary action on the
part of the Company and no further action is required by the Company. Each of
the Transaction Documents has been duly executed by the Company and, when
delivered in accordance with the terms hereof, will constitute the valid and
binding obligation of the Company enforceable against the Company in accordance
with its terms. Neither the Company nor any Subsidiary is in violation of any of
the provisions of its respective articles or certificate of incorporation,
by-laws or other charter or organizational documents.

              (c) Capitalization. The number of authorized, issued and
outstanding capital stock of the Company is set forth in Schedule 2.1(c). Except
as disclosed in Schedule 2.1(c), the Company owns all of the capital stock of
each Subsidiary , free and clear of any lien, charge, security interest,
encumbrance, adverse claim or other restriction, and all the issued and
outstanding shares of capital stock of the Subsidiaries are validly issued and
are fully paid, non-assessable and free of preemptive and similar rights. No
shares of Common Stock are entitled to preemptive or similar rights, nor is any
holder of the Common Stock entitled to preemptive or similar rights arising out
of any agreement or understanding with the Company by virtue of any of the
Transaction Documents. Except as a result of the purchase and sale of the Shares
and the Warrants and except as disclosed in Schedule 2.1(c), there are no
outstanding options, warrants, script rights to subscribe to, calls or
commitments of any character whatsoever relating to, or securities, rights or
obligations convertible into or exchangeable for, or giving any Person any right
to subscribe for or acquire, any shares of Common Stock, or contracts,
commitments, understandings, or arrangements by which the Company or any
Subsidiary is or may become bound to issue additional shares of Common Stock, or
securities or rights convertible or exchangeable into shares of Common Stock.
Except as


<PAGE>

set forth in Schedule 2.1(c): (i) there are no outstanding debt securities
issued by the Company; (ii) there are no outstanding securities of the Company
or any Subsidiary which contain any redemption or similar provisions, and there
are no contracts, commitments, understandings or arrangements by which the
Company or any Subsidiary is or may become bound to redeem a security of the
Company or any Subsidiary; (iii) there are no securities or instruments
containing anti-dilution or similar provisions that will be triggered by the
issuance of the Securities as described in this Agreement; and (iv) the Company
does not have any stock appreciation rights or "phantom stock" plans or
agreements or any similar plan or agreement.

              (d) Issuance of the Securities. The Securities are duly authorized
and, each of the Shares and the Underlying Shares (as defined herein) when
issued and paid for in accordance with the terms hereof and the Warrants,
respectively, shall have been duly and validly issued, fully paid and
nonassessable, free and clear of all liens, encumbrances and rights of first
refusal of any kind (collectively, "Liens"). The Company has reserved a number
of duly authorized shares of Common Stock for issuance hereunder upon exercise
of the Warrants that is not less than the sum of (i) the Shares to be issued
hereunder; (ii) the number of shares of Common Stock issuable upon exercise of
the Adjustable Warrants on the First Vesting Date (as defined in the Adjustable
Warrant), assuming for such purposes that, on the First Vesting Date, (A) the
Applicable Share Number (as defined in the Adjustable Warrant) equals the entire
number of Shares purchased hereunder and (B) the Adjustment Price (as defined in
the Adjustable Warrant) equals 50% of the Per Share Market Value on the Trading
Day immediately preceding the Closing Date, and (iii) the number of shares of
Common Stock as are issuable upon exercise in full of the Closing Warrants (the
number of shares of Common Stock contemplated in (i), (ii) and (iii), the
"Initial Minimum"). The shares of Common Stock issuable upon exercise of the
Warrants are referred to herein as the "Underlying Shares." The Shares, the
Warrants and the Underlying Shares are collectively referred to herein as the
"Securities."

              (e) No Conflicts. The execution, delivery and performance of the
Transaction Documents by the Company and the consummation by the Company of the
transactions contemplated thereby do not and will not (i) conflict with or
violate any provision of the Company's or any Subsidiary's certificate or
articles of incorporation, bylaws or other charter documents (each as amended
through the date hereof), or (ii) subject to obtaining the Required Approvals
(as defined below), conflict with, or constitute a default (or an event which
with notice or lapse of time or both would become a default) under, or give to
others any rights of termination, amendment, acceleration or cancellation (with
or without notice, lapse of time or both) of, any agreement, credit facility,
debt or other instrument (evidencing a Company or Subsidiary debt or otherwise)
or other understanding to which the Company or any Subsidiary is a party or by
which any property or asset of the Company or any Subsidiary is bound or
affected, or (iii) result in a violation of any law, rule, regulation, order,
judgment, injunction, decree or other restriction of any court or governmental
authority to which the Company or a


<PAGE>

Subsidiary is subject (including federal and state securities laws and
regulations), or by which any property or asset of the Company or a Subsidiary
is bound or affected; except in the case of each of clauses (ii) and (iii), as
could not, individually or in the aggregate, have or result in a Material
Adverse Effect. The business of the Company is not being conducted in violation
of any law, ordinance or regulation of any governmental authority, except for
violations which, individually or in the aggregate, could not have or result in
a Material Adverse Effect.

              (f) Filings, Consents and Approvals. Neither the Company nor any
Subsidiary is required to obtain any consent, waiver, authorization or order of,
give any notice to, or make any filing or registration with, any court or other
federal, state, local or other governmental authority or other Person in
connection with the execution, delivery and performance by the Company of the
Transaction Documents, other than (i) the filings required pursuant to Section
3.9, (ii) the filing with the Securities and Exchange Commission (the
"Commission") of a registration statement meeting the requirements set forth in
the Registration Rights Agreement and covering the resale of the Shares and the
Underlying Shares by the Purchasers (the "Underlying Shares Registration
Statement"), (iii) the application(s) to the Nasdaq SmallCap Market ("NASDAQ")
for the listing of the Shares and the Underlying Shares with NASDAQ (and with
any other national securities exchange or market in which the Common Stock is
then listed) in the time and manner required thereby, (iv) applicable Blue Sky
filings, and (v) in all other cases where the failure to obtain such consent,
waiver, authorization or order, or to give such notice or make such filing or
registration could not have or result in, individually or in the aggregate, a
Material Adverse Effect (the items described in clauses (i)-(v) are
collectively, the "Required Approvals").

              (g) Litigation; Proceedings. There is no action, suit, inquiry,
notice of violation, proceeding or investigation pending or, to the knowledge of
the Company, threatened against or affecting the Company or any of its
Subsidiaries or any of their respective properties before or by any court,
arbitrator, governmental or administrative agency or regulatory authority
(federal, state, county, local or foreign) (collectively, an "Action") which (i)
adversely affects or challenges the legality, validity or enforceability of any
of the Transaction Documents or the Securities or (ii) could, individually or in
the aggregate, have or result in a Material Adverse Effect.

              (h) No Default or Violation. Except as set forth in Schedule
2.1(h), neither the Company nor any Subsidiary (i) is in default under or in
violation of (and no event has occurred which has not been waived which, with
notice or lapse of time or both, would result in a default by the Company or any
Subsidiary under), nor has the Company or any Subsidiary received notice of a
claim that it is in default under or that it is in violation of, any indenture,
loan or credit agreement or any other agreement or instrument to which it is a
party or by which it or any of its properties is bound, (ii) is in violation of
any order of any court, arbitrator or governmental body, or (iii) is in
violation of any statute, rule or regulation of any governmental authority, in
each case of clauses


<PAGE>

(i), (ii) or (iii) above, except as could not individually or in the aggregate,
have or result in a Material Adverse Effect.

              (i) Private Offering. Assuming the accuracy of the representations
and warranties of the Purchasers set forth in Sections 2.2(b)-(g), the offer,
issuance and sale of the Securities to the Purchasers as contemplated hereby are
exempt from the registration requirements of the Securities Act of 1933, as
amended (the "Securities Act"). Neither the Company nor any Person acting on its
behalf has taken or is, to the knowledge of the Company, contemplating taking
any action which could subject the offering, issuance or sale of the Securities
to the registration requirements of the Securities Act including soliciting any
offer to buy or sell the Securities by means of any form of general solicitation
or advertising.

              (j) SEC Documents; Financial Statements. The Company has filed all
reports required to be filed by it under the Securities Exchange Act of 1934, as
amended (the "Exchange Act") pursuant to Section 13(a) or 15(d) thereof, for the
two years preceding the date hereof (or such shorter period as the Company was
required by law to file such material) (the foregoing materials being
collectively referred to herein as the "SEC Documents" and, together with the
Schedules to this Agreement, the "Disclosure Materials") on a timely basis or
has received a valid extension of such time of filing and has filed any such SEC
Documents prior to the expiration of any such extension. As of their respective
dates, the SEC Documents complied in all material respects with the requirements
of the Exchange Act and the rules and regulations of the Commission promulgated
thereunder, and none of the SEC Documents, when filed, contained any untrue
statement of a material fact or omitted to state a material fact required to be
stated therein or necessary in order to make the statements therein, in light of
the circumstances under which they were made, not misleading. All material
agreements to which the Company is a party or to which the property or assets of
the Company are subject have been filed as exhibits to the SEC Documents as
required. The financial statements of the Company included in the SEC Documents
comply in all material respects with applicable accounting requirements and the
rules and regulations of the Commission with respect thereto as in effect at the
time of filing. Such financial statements have been prepared in accordance with
generally accepted accounting principles applied on a consistent basis during
the periods involved ("GAAP"), except as may be otherwise specified in such
financial statements or the notes thereto, and fairly present in all material
respects the financial position of the Company and its consolidated subsidiaries
as of and for the dates thereof and the results of operations and cash flows for
the periods then ended, subject, in the case of unaudited statements, to normal,
immaterial, year-end audit adjustments. Since December 31, 1999, except as
specifically disclosed in the SEC Documents, (a) there has been no event,
occurrence or development that has or that could result in a Material Adverse
Effect, (b) the Company has not incurred any liabilities (contingent or
otherwise) other than (x) liabilities incurred in the ordinary course of
business consistent with past practice and (y) liabilities not required to be
reflected in the Company's financial statements pursuant to GAAP or required to
be


<PAGE>

disclosed in filings made with the Commission, (c) the Company has not altered
its method of accounting or the identity of its auditors and (d) the Company has
not declared or made any payment or distribution of cash or other property to
its stockholders or officers or directors (other than in compliance with
existing Company stock option plans) with respect to its capital stock, or
purchased, redeemed (or made any agreements to purchase or redeem) any shares of
its capital stock. The Company shall be eligible to register its Common Stock
for resale under Form S-3 promulgated under the Securities Act no later than May
23, 2000.

              (k) Investment Company. The Company is not, and is not an
Affiliate (as defined in Rule 405 under the Securities Act) of, an "investment
company" within the meaning of the Investment Company Act of 1940, as amended.

              (l) Certain Fees. Except for certain fees payable to Gerard Klauer
Mattison & Co. and George K. Baum & Company, by the Company, no fees or
commissions will be payable by the Company to any broker, financial advisor or
consultant, finder, placement agent, investment banker, bank or other Person
with respect to the transactions contemplated by this Agreement. The Purchasers
shall have no obligation with respect to any fees or with respect to any claims
made by or on behalf of other Persons for fees of a type contemplated in this
Section that may be due in connection with the transactions contemplated by this
Agreement. The Company shall indemnify and hold harmless the Purchasers, their
employees, officers, directors, agents, and partners, and their respective
Affiliates, from and against all claims, losses, damages, costs (including the
costs of preparation and attorney's fees) and expenses suffered in respect of
any such claimed or existing fees, as such fees and expenses are incurred.

              (m) Solicitation Materials. Neither the Company nor any Person
acting on the Company's behalf has solicited any offer to buy or sell the
Securities by means of any form of general solicitation or advertising.

              (n) Listing and Maintenance Requirements. The Company has not, in
the two years preceding the date hereof received notice (written or oral) from
NASDAQ or any other stock exchange, market or trading facility on which the
Common Stock is or has been listed (or on which it has been quoted) to the
effect that the Company is not in compliance with the listing or maintenance
requirements of such exchange, market or trading facility. The Company is, and
has no reason to believe that it will not in the foreseeable future continue to
be, in compliance with all such listing and maintenance requirements.

              (o) Patents and Trademarks. The Company and its Subsidiaries have,
or have rights to use, all patents, patent applications, trademarks, trademark
applications, service marks, trade names, copyrights, licenses and rights which
are necessary or material for use in connection with their respective business
as described in the SEC Documents and which the failure to so have would have a
Material Adverse



<PAGE>

Effect (collectively, the "Intellectual Property Rights"). Except as set forth
in Schedule 2.1(p), neither the Company nor any Subsidiary has received a
written notice that the Intellectual Property Rights used by the Company or its
Subsidiaries violates or infringes upon the rights of any Person, to the best
knowledge of the Company. All such Intellectual Property Rights are enforceable
and to the best of the Company's knowledge there is no existing infringement by
another Person of any of the Intellectual Property Rights.

              (p) Regulatory Permits. The Company and its Subsidiaries possess
all certificates, authorizations and permits issued by the appropriate federal,
state or foreign regulatory authorities necessary to conduct their respective
businesses as described in the SEC Documents, except where the failure to
possess such permits could not, individually or in the aggregate, have or result
in a Material Adverse Effect ("Material Permits"), and neither the Company nor
any such Subsidiary has received any notice of proceedings relating to the
revocation or modification of any Material Permit.

              (q) Title. The Company and the Subsidiaries have good and
marketable title in fee simple to all real property owned by them which is
material to the business of the Company and its Subsidiaries and good and
marketable title in all personal property owned by them which is material to the
business of the Company and its Subsidiaries, in each case free and clear of all
Liens, except for Liens as do not materially affect the value of such property
and do not interfere with the use made and proposed to be made of such property
by the Company and its Subsidiaries. Any real property and facilities held under
lease by the Company and its Subsidiaries are held by them under valid,
subsisting and enforceable leases of which the Company and its Subsidiaries are
in compliance and do not interfere with the use made and proposed to be made of
such property and buildings by the Company and its Subsidiaries.

              (r) Registration Rights; Rights of Participation. Except as
disclosed under Section 6(c) of the Registration Rights Agreement, the Company
has not granted or agreed to grant to any Person any rights (including
"piggy-back" registration rights) to have any securities of the Company
registered with the Commission or any other governmental authority which has not
been satisfied. Except as set forth on Schedule 6(b) to the Registration Rights
Agreement, no Person has any right of first refusal, preemptive right, right of
participation, or any similar right to participate in the transactions
contemplated by the Transaction Documents.

              (s) Absence of Certain Proceedings. Except as described in the SEC
Documents, (i) there is no Action pending or, to the knowledge of the Company,
threatened against the Company, in any such case wherein an unfavorable
decision, ruling or finding could have or result in a Material Adverse Effect;
(ii) neither the Company nor any Subsidiary, nor any director or officer
thereof, is or has been the subject of any Action involving (A) a claim of
violation of or liability under federal or state securities laws or (B) a claim
of breach of fiduciary duty; (iii) the Company does not


<PAGE>

have pending before the Commission any request for confidential treatment of
information and the Company has no knowledge of any expected such request that
would be made prior to the Effectiveness Date (as defined in the Registration
Rights Agreement); and (iv) there has not been, and to the best of the Company's
knowledge there is not pending or contemplated, any investigation by the
Commission involving the Company or any current or former director or officer of
the Company.

              (t) Labor Relations. No material labor problem exists or, to the
knowledge of the Company, is imminent with respect to any of the employees of
the Company. None of the Company's or any Subsidiary's employees is a member of
a union, neither the Company nor any Subsidiary is a party to a collective
bargaining agreement, and the Company and the Subsidiaries believe that their
relations with their employees are good. No executive officer (as defined in
Rule 501(f) of the Securities Act) has notified the Company's Board of Directors
that such officer intends to leave the Company or otherwise terminate such
officer's employment with the Company and the Company does not expect to
terminate any such officer during the six months following the date of this
Agreement.

              (u) Transactions With Affiliates and Employees. Except as set
forth on Schedule 2.1(v) or in the SEC Documents filed at least ten days prior
to the date hereof and other than the grant or exercise of stock options
disclosed in Section 2.1(c), none of the officers or directors of the Company
and, to the Company's knowledge, none of the employees of the Company is
presently a party to any transaction with the Company or any Subsidiary (other
than for services as employees, officers and directors), including any contract,
agreement or other arrangement providing for the furnishing of services to or
by, providing for rental of real or personal property to or from, or otherwise
requiring payments to or from any officer, director or such employee or, to the
knowledge of the Company, any corporation, partnership, trust or other entity in
which any officer, director, or any such employee has a substantial interest or
is an officer, director, trustee or partner.

              (v) Application of Takeover Protections. The Company and its Board
of Directors have taken all necessary action, if any, in order to render
inapplicable any control share acquisition, business combination, poison pill
(including any distribution under a rights agreement) or other similar
anti-takeover provision under the Certificate of Incorporation or the laws of
the State of Nevada which is or could become applicable to the Purchasers as a
result of the Purchasers and the Company fulfilling their obligations under the
Transaction Documents, including, without limitation, the Company's issuance of
the Securities and the Purchasers' ownership of the Securities.

              (w) Effectiveness of SEC Filings. The SEC has not issued any stop
order or other order suspending the effectiveness of any registration statement
filed by the Company or any Subsidiary under the Exchange Act or the Securities
Act.


<PAGE>

              (x) No Integration. Neither the Company nor any of its affiliates
nor any person acting on the Company's behalf has, directly or indirectly, at
any time within the past six (6) months made any offer or sale of any security
or solicitation of any offer to buy any security under circumstances that would
(i) eliminate the availability of the exemption from registration under
Regulation D under the Securities Act in connection with the offer and sale of
the Securities as contemplated hereby or (ii) cause the offering of the
Securities pursuant to this Agreement to be integrated with prior offerings by
the Company for purposes of any applicable shareholder approval provisions
including, without limitation, under the rules and regulations of the Nasdaq
Stock Market, Inc., as applicable.

              (y) Taxes. All applicable tax returns required to be filed by the
Company and the Subsidiaries have been filed, or if not yet filed have been
granted extensions of the filing dates which extensions have not expired, and
all taxes, assessments, fees and other governmental charges upon the Company,
the Subsidiaries or upon any of their respective properties, income or
franchises, shown in such returns and on assessments received by the Company or
the Subsidiaries to be due and payable have been paid, or adequate reserves
therefor have been set up if any of such taxes are being contested in good
faith; or if any of such tax returns or extensions requested have not been filed
or if any such taxes have not been paid or so reserved for, the failure to so
file or to pay would not in the aggregate or individually have a Material
Adverse Effect.

              (z) Disclosure. The Company confirms that neither it nor any other
Person acting on its behalf has provided any of the Purchasers or its agents or
counsel with any information that constitutes or might constitute material
non-public information. The Company understands and confirms that the Purchasers
shall be relying on the foregoing representations in effecting transactions in
securities of the Company. All disclosure provided to the Purchasers regarding
the Company, its business and the transactions contemplated hereby, including
the Schedules to this Agreement, furnished by or on behalf of the Company are
true and correct and do not contain any untrue statement of a material fact or
omit to state any material fact necessary in order to make the statements made
therein, in the light of the circumstances under which they were made, not
misleading.

     2.2 Representations and Warranties of the Purchasers. Each Purchaser hereby
for itself and for no other Purchaser, represents and warrants to the Company as
follows:

              (a) Organization; Authority. Such Purchaser is an entity duly
organized, validly existing and in good standing under the laws of the
jurisdiction of its organization with the requisite corporate or partnership
power and authority to enter into and to consummate the transactions
contemplated by the Transaction Documents and otherwise to carry out its
obligations thereunder. The purchase by such Purchaser of the Securities
hereunder has been duly authorized by all necessary action on the part of such
Purchaser. Each of this Agreement, the Letter Agreement and the Registration
Rights


<PAGE>

Agreement has been duly executed by such Purchaser, and when delivered by such
Purchaser in accordance with the terms hereof, will constitute the valid and
legally binding obligation of such Purchaser, enforceable against it in
accordance with its terms.

              (b) Investment Intent. Such Purchaser is acquiring the Securities
as principal for its own account for investment purposes only and not with a
view to or for distributing or reselling such Securities or any part thereof,
without prejudice, however, to such Purchaser's right, subject to the provisions
of this Agreement, the Registration Rights Agreement and the Warrant, at all
times to sell or otherwise dispose of all or any part of such Securities
pursuant to an effective registration statement under the Securities Act or
under an exemption from such registration statement and in compliance with
applicable federal and state securities laws. Such Purchaser is acquiring the
Securities hereunder in the ordinary course of its business. Such Purchaser does
not have any agreement or understanding, directly or indirectly, with any person
to distribute the Securities.

              (c) Purchaser Status. At the time such Purchaser was offered the
Securities, it was, and at the date hereof it is, and at each exercise date
under its respective Warrants, it will be, an "accredited investor" as defined
in Rule 501(a) under the Securities Act. Such Purchaser has not been formed
solely for the purpose of acquiring the Securities.

              (d) Experience of such Purchaser. Such Purchaser, either alone or
together with its representatives, has such knowledge, sophistication and
experience in business and financial matters so as to be capable of evaluating
the merits and risks of the prospective investment in the Securities, and has so
evaluated the merits and risks of such investment.

              (e) Ability of such Purchaser to Bear Risk of Investment. Such
Purchaser is able to bear the economic risk of an investment in the Securities
and, at the present time, is able to afford a complete loss of such investment.

              (f) Access to Information. Such Purchaser acknowledges that it has
reviewed the Disclosure Materials and has been afforded (i) the opportunity to
ask such questions as it has deemed necessary of, and to receive answers from,
representatives of the Company concerning the terms and conditions of the
offering of the Securities and the merits and risks of investing in the
Securities; (ii) access to information about the Company and the Company's
financial condition, results of operations, business, properties, management and
prospects sufficient to enable it to evaluate its investment; and (iii) the
opportunity to obtain such additional information which the Company possesses or
can acquire without unreasonable effort or expense that is necessary to make an
informed investment decision with respect to the investment and to verify the
accuracy and completeness of the information contained in the Disclosure
Materials. Neither such inquiries nor any other investigation conducted by or on
behalf


<PAGE>

of such Purchaser or its representatives or counsel shall modify, amend or
affect such Purchaser's right to rely on the truth, accuracy and completeness of
the Disclosure Materials and the Company's representations and warranties
contained in the Transaction Documents.

              (g) General Solicitation. Such Purchaser is not purchasing the
Securities as a result of or subsequent to any advertisement, article, notice or
other communication regarding the Securities published in any newspaper,
magazine or similar media or broadcast over television or radio or presented at
any seminar or any other general solicitation or general advertisement.

              (h) Reliance. Such Purchaser understands and acknowledges that (i)
the Securities are being offered and sold to it without registration under the
Securities Act in a private placement that is exempt from the registration
provisions of the Securities Act and (ii) the availability of such exemption,
depends in part on, and the Company will rely upon the accuracy and truthfulness
of, the foregoing representations and such Purchaser hereby consents to such
reliance.

                  The Company acknowledges and agrees that no Purchaser makes or
has made any representations or warranties with respect to the transactions
contemplated hereby other than those specifically set forth in this Section 2.2.

                                  ARTICLE III
                         OTHER AGREEMENTS OF THE PARTIES

     3.1 Transfer Restrictions. (a) Securities may only be disposed of pursuant
to an effective registration statement under the Securities Act, to the Company
or pursuant to an available exemption from or in a transaction not subject to
the registration requirements of the Securities Act, and in compliance with any
applicable federal and state securities laws. In connection with any transfer of
Securities other than pursuant to an effective registration statement or to the
Company, except as otherwise set forth herein, the Company may require the
transferor thereof to provide to the Company an opinion of counsel selected by
the transferor, the form and substance of which opinion shall be reasonably
satisfactory to the Company, to the effect that such transfer does not require
registration of such transferred securities under the Securities Act.
Notwithstanding the foregoing, the Company, without requiring a legal opinion as
described in the immediately preceding sentence, hereby consents to and agrees
to register on the books of the Company and with any transfer agent for the
securities of the Company any transfer of Securities by a Purchaser to an
Affiliate of such Purchaser or to one or more funds or managed accounts under
common management with such Purchaser, and any transfer among any such
Affiliates or one or more funds or managed accounts, provided that the
transferee certifies to the Company that it is an "accredited investor" as
defined in Rule 501(a) under the Securities Act and that it is acquiring the
Securities solely for investment purposes (subject to the qualifications
hereof). Any such transferee shall agree in writing to be bound by the terms of
this


<PAGE>

Agreement and shall have the rights of a Purchaser under this Agreement and the
Registration Rights Agreement.

              (b) The Purchasers agree to the imprinting, so long as is required
by this Section 3.1(b), of the following
legend on the Securities:

         [NEITHER] THESE SECURITIES [NOR THE SECURITIES INTO WHICH THESE
         SECURITIES ARE EXERCISABLE] HAVE BEEN REGISTERED WITH THE SECURITIES
         AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN
         RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT
         OF 1933, AS AMENDED (THE "SECURITIES ACT"), AND, ACCORDINGLY, MAY NOT
         BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
         STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE
         EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION
         REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE
         STATE SECURITIES LAWS.

                  Neither the Shares nor Underlying Shares shall contain the
legend set forth above nor any other legend at any time while an Underlying
Shares Registration Statement is effective under the Securities Act or the
holder is relying on Rule 144 promulgated under the Securities Act ("Rule 144")
in connection with the resale of such Underlying Shares or, in the event there
is not an effective Underlying Shares Registration Statement at such time and
Rule 144 is not then available, if such legend is not required under applicable
requirements of the Securities Act (including judicial interpretations and
pronouncements issued by the staff of the Commission). The Company shall cause
its counsel to issue the legal opinion included in the Transfer Agent
Instructions to the Company's transfer agent on the date that such Underlying
Shares Registration Statement is declared effective by the Commission (the
"Effective Date"). The Company agrees that following the Effective Date, it
will, no later than three (3) Trading Days following the delivery by a Purchaser
to the Company of a certificate or certificates representing Shares, deliver to
such Purchaser an identical certificate or certificates representing such Shares
which shall be free from such legend. The Company further agrees that if any
Shares or Underlying Shares are issued with a legend in accordance with this
Section 3.1(b), it will, within three (3) Trading Days after request therefor by
a Purchaser, provide such Purchaser with a certificate or certificates
representing such Shares or Underlying Shares, free from such legend at such
time as such legend would not have been required under this Section 3.1(b) had
such issuance occurred on the date of such request. The Company may not make any
notation on its records or give instructions to any transfer agent of the
Company which enlarge the restrictions of transfer set forth in this Section.

     3.2 Acknowledgment of Dilution. The Company acknowledges that the issuance
of Underlying Shares upon exercise of the Warrants will result in dilution of
the outstanding shares of Common Stock, which dilution may be substantial under
certain market conditions. The Company further acknowledges that its obligation
to issue Underlying Shares upon exercise of


<PAGE>

the Warrants pursuant to the terms thereof is unconditional and absolute
(subject to the limitations set forth in the Warrants) regardless of the effect
of any such dilution.

     3.3 Furnishing of Information. As long as the Purchasers own Securities,
the Company covenants to timely file (or obtain extensions in respect thereof
and file within the applicable grace period) all reports required to be filed by
the Company after the date hereof pursuant to Section 13(a) or 15(d) of the
Exchange Act. As long as the Purchasers own Securities, if the Company is not
required to file reports pursuant to such sections, it will prepare and furnish
to the Purchasers and make publicly available in accordance with Rule 144(c)
promulgated under the Securities Act such information as is required for the
Purchasers to sell the Securities under Rule 144 promulgated under the
Securities Act. The Company further covenants that it will take such further
action as any holder of Securities may reasonably request, all to the extent
required from time to time to enable such Person to sell Underlying Shares
without registration under the Securities Act within the limitation of the
exemptions provided by Rule 144 promulgated under the Securities Act, including
causing its attorneys to render and deliver any legal opinion required in order
to permit a Purchaser to sell Underlying Shares under Rule 144 upon notice of an
intention to sell or other form of notice having a similar effect and other
standard Rule 144 documentation. Upon the request of any such Person, the
Company shall deliver to such Person a written certification of a duly
authorized officer as to whether it has complied with such requirements.

     3.4 Integration. The Company shall not, and shall use its best efforts to
ensure that, no Affiliate of the Company shall, sell, offer for sale or solicit
offers to buy or otherwise negotiate in respect of any security (as defined in
Section 2 of the Securities Act) that would be integrated with the offer or sale
of the Securities in a manner that would require the registration under the
Securities Act of the sale of the Securities to the Purchasers or that would be
integrated with the offer or sale of the Securities for purposes of the rules
and regulations of the NASDAQ.

     3.5 Increase in Authorized Shares. If on any date the Company would be, if
a notice of exercise were to be delivered on such date, precluded from issuing
the sum of (i) twice the number of Underlying Shares then issuable upon exercise
in full of the Adjustable Warrants and (ii) the number of Underlying Shares
issuable upon exercise in full of the Closing Warrants (the "Current Required
Minimum") due to the unavailability of a sufficient number of authorized but
unissued or reserved shares of Common Stock, then the Board of Directors of the
Company shall promptly (and in any case, within 30 Business Days from such date)
prepare and mail to the stockholders of the Company proxy materials requesting
authorization to amend the Company's certificate or articles of incorporation to
increase the number of shares of Common Stock which the Company is authorized to
issue to at least such number of shares as reasonably requested by the
Purchasers in order to provide for such number of authorized and unissued shares
of Common Stock to enable the Company to comply with its issuance, exercise and
reservation of shares obligations as set forth in this Agreement and the
Warrants (the sum of (x) the number of shares of Common Stock then outstanding
plus all shares of Common Stock issuable upon exercise of all outstanding
options, warrants and convertible instruments other than the Warrants, and (y)
the Current Required Minimum, shall be a reasonable number). In connection
therewith,


<PAGE>

the Board of Directors shall (a) adopt proper resolutions authorizing such
increase, (b) recommend to and otherwise use its best efforts to promptly and
duly obtain stockholder approval to carry out such resolutions (and hold a
special meeting of the stockholders no later than the earlier to occur of the
60th day after delivery of the proxy materials relating to such meeting and the
90th day after request by a holder of Warrants to issue the number of Underlying
Shares in accordance with the terms hereof) and (c) within five (5) Business
Days of obtaining such stockholder authorization, file an appropriate amendment
to the Company's certificate or articles of incorporation to evidence such
increase. Management of the Company shall also use its best efforts, including
voting of all shares of Common Stock held by Management in favor of all
resolutions to increase the authorized stock of the Company hereunder.

     3.6 Reservation and Listing of Underlying Shares. (a) The Company shall (i)
promptly prepare and file with the NASDAQ (and such other national securities
exchange or market or trading or quotation facility on which the Common Stock is
then listed for trading) an additional shares listing application covering a
number of shares of Common Stock which is not less than the Initial Minimum,
(ii) take all steps necessary to cause such shares of Common Stock to be
approved for listing on the NASDAQ (as well as on any such other national
securities exchange or market or trading or quotation facility on which the
Common Stock is then listed) as soon as possible thereafter, and (iii) provide
to the Purchasers evidence of such listing, and the Company shall maintain the
listing of its Common Stock thereon. If the number of Underlying Shares issuable
upon exercise of the then unexercised portion of the Warrants exceeds 85% of the
number of Underlying Shares previously listed on account thereof with the NASDAQ
(and any such other required exchanges), then the Company shall take the
necessary actions to immediately list a number of Underlying Shares as equals no
less than the then Current Required Minimum with respect thereto.

              (b) The Company shall maintain a reserve of shares of Common Stock
for issuance upon exercise in full of the Warrants in accordance with the
Warrants, in such amount as may be required to fulfill its obligations in full
under the Transaction Documents, which reserve shall equal no less than the then
Current Required Minimum.

     3.7 Exercise Procedures. The Transfer Agent Instructions and Form of
Election to Purchase under the Warrants set forth the totality of the procedures
with respect to the exercise of the Warrants, including the form of legal
opinion, if necessary, that shall be rendered to the Company's transfer agent
and such other information and instructions as may be reasonably necessary to
enable the Purchasers to exercise the Warrants.

     3.8 Right of First Refusal; Subsequent Registrations. (a) Neither Company
nor any Subsidiary shall directly or indirectly, without the prior written
consent of the Purchasers, offer, sell, grant any option to purchase, or
otherwise dispose of (or announce any offer, sale, grant or any option to
purchase or other disposition) any securities including the issuance of any debt
or other instrument that at any time over the life thereof is convertible into
or exchangeable


<PAGE>

for Common Stock, or any other transaction intended to be exempt or not subject
to registration under the Securities Act (a "Subsequent Placement") until the
180th Trading Day following the Effective Date provided, that such 180 Trading
Day period shall be extended for the number of Trading Days during such period
(A) in which trading in the Common Stock is suspended by the NASDAQ or such
market or quotation system on which the Common Stock is then listed, or (B)
during which the Underlying Shares Registration Statement is not effective, or
(C) during which the prospectus included in the Underlying Shares Registration
Statement may not be used by the holders thereof for the resale of Underlying
Shares, except (i) the granting of options or warrants to employees, officers
and directors, and the issuance of shares upon exercise of options granted,
under any stock option plan heretofore or hereinafter duly adopted by the
Company, (ii) shares of Common Stock issuable upon exercise of currently
outstanding options and warrants and upon conversion of any currently
outstanding convertible securities of the Company, in each case to the extent
disclosed in Schedule 2.1(c) but not with respect to any amendment or
modification thereof, (iii) shares of Common Stock issuable upon exercise of the
Warrants in accordance with the terms thereof and (iv) the issuance of shares of
Common Stock and warrants to purchase Common Stock for an aggregate purchase
price of up to $5,000,000 pursuant to a private placement memorandum dated March
10, 2000, unless (A) the Company delivers to each Purchaser a written notice
(the "Subsequent Placement Notice") of its intention to effect such Subsequent
Placement, which Subsequent Placement Notice shall describe in reasonable detail
the proposed terms of such Subsequent Placement, the amount of proceeds intended
to be raised thereunder, the Person with whom such Subsequent Placement shall be
effected, and attached to which shall be a term sheet or similar document
relating thereto and (B) such Purchaser shall not have notified the Company by
6:30 p.m. (New York City time) on the tenth (10th) Trading Day after its receipt
of the Subsequent Placement Notice of its willingness to cause such Purchaser to
provide (or to cause its sole designee to provide), subject to completion of
mutually acceptable documentation, financing to the Company on the same terms
set forth in the Subsequent Placement Notice. If the Purchasers shall fail to
notify the Company of their intention to enter into such negotiations within
such time period, the Company may effect the Subsequent Placement substantially
upon the terms and to the Persons (or Affiliates of such Persons) set forth in
the Subsequent Placement Notice; provided, that the Company shall provide the
Purchasers with a second Subsequent Placement Notice, and the Purchasers shall
again have the right of first refusal set forth above in this Section (a), if
the Subsequent Placement subject to the initial Subsequent Placement Notice
shall not have been consummated for any reason on the terms set forth in such
Subsequent Placement Notice within forty (40) Trading Days after the date of the
initial Subsequent Placement Notice with the Person (or an Affiliate of such
Person) identified in the Subsequent Placement Notice. If the Purchasers shall
indicate a willingness to provide financing in excess of the amount set forth in
the Subsequent Placement Notice, then each Purchaser shall be entitled to
provide financing pursuant to such Subsequent Placement Notice up to an amount
equal to such Purchaser's pro-rata portion of the aggregate number of Shares
purchased by such Purchaser under this Agreement, but the Company shall not be
required to accept financing from the Purchasers in an amount in excess of the
amount set forth in the Subsequent Placement Notice. The rights of the
Purchasers under this Section shall apply to each Subsequent Placement
contemplated by the Company or such Subsidiary, regardless of any prior waivers
or non-participation.


<PAGE>



              (b) Except for Shares, Underlying Shares and other "Registrable
Securities" (as such term is defined in the Registration Rights Agreement) to be
registered, and securities of the Company as set forth in Section 6(c) of the
Registration's Rights Agreement to be registered, in the Underlying Shares
Registration Statement in accordance with the Registration Rights Agreement, and
Common Stock permitted to be issued pursuant to paragraph (a)(i) - (iv) of
Section 3.8 (a), the Company shall not for a period of 90 Trading Days after the
Effective Date, without the prior written consent of the Purchasers (i) issue or
sell any of its or any of its Affiliates' equity or equity-equivalent securities
pursuant to Regulation S promulgated under the Securities Act, or (ii) file a
registration statement for the issuance or resale of any securities of the
Company. Any days after the Effective Date that a Purchaser is not permitted or
unable to utilize the prospectus or otherwise to resell Shares or Underlying
Shares under the Underlying Shares Registration Statement shall be added to such
90 Trading Day period for the purposes of this Section.

     3.9 Certain Securities Laws Disclosures; Publicity. The Company shall: (i)
within 1 day following the Closing Date, the Closing Date issue a press release
acceptable to the Purchasers disclosing the transactions contemplated hereby,
(ii) file with the Commission a Report on Form 8-K, disclosing the transactions
contemplated hereby within ten (10) Business Days after the Closing Date, and
(iii) timely file with the Commission a Form D promulgated under the Securities
Act as required under Regulation D promulgated under the Securities Act and
provide a copy thereof to the Purchasers promptly after the filing thereof. The
Company shall, no less than two (2) Business Days prior to the filing of any
disclosure required by clauses (ii) and (iii) above, provide a copy thereof to
the Purchasers. The Company and the Purchasers shall consult with each other in
issuing any press releases or otherwise making public statements or filings and
other communications with the Commission or any regulatory agency or stock
market or trading facility with respect to the transactions contemplated hereby
and neither party shall issue any such press release or otherwise make any such
public statement, filings or other communications without the prior written
consent of the other, which consent shall not be unreasonably withheld or
delayed, except that no prior consent shall be required if such disclosure is
required by law, in which such case the disclosing party shall provide the other
party with prior notice of such public statement, filing or other communication.
Notwithstanding the foregoing, the Company shall not publicly disclose the names
of the Purchasers, or include the names of the Purchasers in any filing with the
Commission, or any regulatory agency, trading facility or stock market without
the prior written consent of the Purchasers, except to the extent such
disclosure (but not any disclosure as to the controlling Persons thereof) is
required by law or regulatory body, in which case the Company shall provide the
Purchasers with prior notice of such disclosure.

     3.10 Use of Proceeds. The Company shall use the net proceeds from the sale
of the Securities hereunder for working capital purposes and not for the
satisfaction of any portion of the Company's debt (excluding payment of trade
payables in the ordinary course of the Company's business and prior practices),
to redeem any Company equity or equity-equivalent securities or to settle any
outstanding litigation.

<PAGE>


     3.11 Reimbursement. In consideration of each Purchaser's execution and
delivery of the Transaction Documents and acquiring the Securities thereunder
and in addition to all of the Company's other obligations under the Transaction
Documents, the Company shall defend, protect, indemnify and hold harmless each
Purchaser and all of their stockholders, partners, members, managers, officers,
directors, employees and direct or indirect investors and any of the foregoing
persons' agents or other representatives (including, without limitation, those
retained in connection with the transactions contemplated by this Agreement)
(collectively, the "Indemnitees") from and against any and all actions, causes
of action, suits, claims, losses, costs, penalties, fees, liabilities and
damages, and expenses in connection therewith (irrespective of whether any such
Indemnitee is a party to the action for which indemnification hereunder is
sought) and including reasonable attorneys' fees, and disbursements (the
"Indemnified Liabilities"), incurred by any Indemnitee, other than by reason of
its gross negligence or willful misconduct as a result of, or arising out of, or
relating to (a) any misrepresentation or breach of any representation or
warranty made by the Company in the Transaction Documents or any other
certificate, instrument or document contemplated hereby or thereby, (b) any
breach of any covenant, agreement or obligation of the Company contained in the
Transaction Documents or any other certificate, instrument or document
contemplated hereby or thereby or (c) any cause of action, suit or claim brought
or made against such Indemnitee (other than a cause of action, suit or claim
which is (x) brought or made by the Company and (y) is not a shareholder
derivative suit) and arising out of or resulting from (i) the execution,
delivery, performance or enforcement of the Transaction Documents, (ii) any
transaction financed or to be financed in whole or in part, directly or
indirectly, with the proceeds of the issuance of the Securities or (iii) solely
from the status of such Purchaser or holder of the Securities as an investor in
the Company. To the extent that the foregoing undertaking by the Company may be
unenforceable for any reason, the Company shall make the maximum contribution to
the payment and satisfaction of each of the Indemnified Liabilities which is
permissible under applicable law.

     3.12 Exchange Act Registration. The Company will: (a) use its best efforts
to cause its Common Stock to continue to be registered under Section 12(b) or
12(g) of the Exchange Act, (b) comply in all respects with its reporting and
filing obligations under the Exchange Act, and (c) not take any action or file
any document (whether or not permitted by the Exchange Act or the rules and
regulations thereunder) to terminate or suspend such registration or to
terminate or suspend its reporting and filing obligations under the Exchange
Act. The Company will take all action necessary to continue the listing and
trading of its Common Stock on NASDAQ or a Subsequent Market and will comply in
all respects with the Company's reporting, filing and other obligations under
the bylaws or rules of the NASD and NASDAQ.

     3.13 Corporate Existence. Prior to the Expiration Date (as defined in the
Adjustable Warrants), the Company shall maintain its corporate existence and
shall not sell all or substantially all of the Company's assets, except in the
event of a merger or consolidation or sale of all or substantially all of the
Company's assets, where the surviving or successor entity in such transaction
(i) assumes the Company's obligations hereunder and under the agreements and
instruments entered into in connection herewith and (ii) is a publicly traded
corporation whose


<PAGE>



common stock is listed for trading on NASDAQ, The Nasdaq National Market, the
New York Stock Exchange or the American Stock Exchange.

     3.14 Dividends and Distributions. During the period in which the Purchasers
shall own Securities, the Company shall not make or fix a record date for the
determination of holders of Common Stock or other securities entitled to receive
a dividend or other distribution (special or otherwise), other than a stock
split in the form of a dividend, or declare a cash dividend or other
distribution payable in cash or property of the Company.

                                   ARTICLE IV
                                  MISCELLANEOUS

     4.1 Fees and Expenses. At the Closing the Company shall reimburse the
Purchasers for their legal fees and expenses incurred in connection with the
preparation and negotiation of the Transaction Documents by paying to Robinson
Silverman $25,000 for the preparation and negotiation of the Transaction
Documents. The amount contemplated by the immediately preceding sentence shall
be retained by the Purchasers and shall not be delivered to the Company at the
Closing. Other than the amount contemplated herein and except as otherwise set
forth in the Registration Rights Agreement, each party shall pay the fees and
expenses of its advisers, counsel, accountants and other experts, if any, and
all other expenses incurred by such party incident to the negotiation,
preparation, execution, delivery and performance of this Agreement. The Company
shall pay all stamp and other taxes and duties levied in connection with the
issuance of the Securities.

     4.2 Entire Agreement; Amendments. The Transaction Documents, together with
the Exhibits and Schedules thereto and the Transfer Agent Instructions, contain
the entire understanding of the parties with respect to the subject matter
hereof and supersede all prior agreements and understandings, oral or written,
with respect to such matters, which the parties acknowledge have been merged
into such documents, exhibits and schedules.

     4.3 Notices. Any and all notices or other communications or deliveries
required or permitted to be provided hereunder shall be in writing and shall be
deemed given and effective on the earliest of (i) the date of transmission, if
such notice or communication is delivered via facsimile at the facsimile
telephone number specified in this Section prior to 6:30 p.m. (New York City
time) on a Business Day, (ii) the Business Day after the date of transmission,
if such notice or communication is delivered via facsimile at the facsimile
telephone number specified in this Agreement later than 6:30 p.m. (New York City
time) on any date and earlier than 11:59 p.m. (New York City time) on such date,
(iii) the Business Day following the date of mailing, if sent by nationally
recognized overnight courier service and marked for next Business Day delivery,
or (iv) upon actual receipt by the party to whom such notice is required to be
given. The address for such notices and communications shall be as follows:


<PAGE>

If to the Company:                 SafeScience, Inc.
                                   Park Square Building
                                   31 St. James Avenue, 8th Floor
                                   Boston, MA 02116
                                   Fax: 617-422-0675
                                   Attn: John Burns, Chief Financial Officer

With a copy to:                    McDermott, Will & Emery
                                   50 Rockefeller Plaza
                                   New York, NY  10020-1605
                                   Facsimile No.:  212-547-5444
                                   Attn:  Cheryl Reicin, Esq.

If                                 to a Purchaser: To the
                                   address set forth under
                                   such Purchaser's name on
                                   the signature pages hereto.


or such other address as may be designated in writing hereafter, in the same
manner, by such Person.

     4.4 Amendments; Waivers. No provision of this Agreement may be waived or
amended except in a written instrument signed, in the case of an amendment, by
both the Company and the Purchasers or, in the case of a waiver, by the party
against whom enforcement of any such waiver is sought. No waiver of any default
with respect to any provision, condition or requirement of this Agreement shall
be deemed to be a continuing waiver in the future or a waiver of any other
provision, condition or requirement hereof, nor shall any delay or omission of
either party to exercise any right hereunder in any manner impair the exercise
of any such right accruing to it thereafter.

     4.5 Headings. The headings herein are for convenience only, do not
constitute a part of this Agreement and shall not be deemed to limit or affect
any of the provisions hereof.

     4.6 Successors and Assigns. This Agreement shall be binding upon and inure
to the benefit of the parties and their successors and permitted assigns. The
Company may not assign this Agreement or any rights or obligations hereunder
without the prior written consent of the Purchasers. Except as set forth in
Section 3.1(a), the Purchasers may not assign this Agreement or any of the
rights or obligations hereunder without the consent of the Company. This
provision shall not limit any Purchaser's right to transfer securities or
transfer or assign rights under the Registration Rights Agreement.

     4.7 No Third-Party Beneficiaries. This Agreement is intended for the
benefit of the parties hereto and their respective successors and permitted
assigns and is not for the benefit of, nor may any provision hereof be enforced
by, any other Person.

<PAGE>


     4.8 Governing Law. The corporate laws of the State of Nevada shall govern
all issues concerning the relative rights of the Company and its stockholders.
All other questions concerning the construction, validity, enforcement and
interpretation of this Agreement shall be governed by and construed and enforced
in accordance with the internal laws of the State of New York, without regard to
the principles of conflicts of law thereof. Each party hereby irrevocably
submits to the exclusive jurisdiction of the state and federal courts sitting in
the City of New York, borough of Manhattan, for the adjudication of any dispute
hereunder or in connection herewith or with any transaction contemplated hereby
or discussed herein (including with respect to the enforcement of the any of the
Transaction Documents), and hereby irrevocably waives, and agrees not to assert
in any suit, action or proceeding, any claim that it is not personally subject
to the jurisdiction of any such court, that such suit, action or proceeding is
improper. Each party hereby irrevocably waives personal service of process and
consents to process being served in any such suit, action or proceeding by
mailing a copy thereof to such party at the address in effect for notices to it
under this Agreement and agrees that such service shall constitute good and
sufficient service of process and notice thereof. Nothing contained herein shall
be deemed to limit in any way any right to serve process in any manner permitted
by law.

     4.9 Survival. The representations, warranties, agreements and covenants
contained herein shall survive the Closing and the delivery and exercise of the
Warrants.

     4.10 Execution. This Agreement may be executed in two or more counterparts,
all of which when taken together shall be considered one and the same agreement
and shall become effective when counterparts have been signed by each party and
delivered to the other party, it being understood that both parties need not
sign the same counterpart. In the event that any signature is delivered by
facsimile transmission, such signature shall create a valid and binding
obligation of the party executing (or on whose behalf such signature is
executed) the same with the same force and effect as if such facsimile signature
page were an original thereof.

     4.11 Severability. In case any one or more of the provisions of this
Agreement shall be invalid or unenforceable in any respect, the validity and
enforceability of the remaining terms and provisions of this Agreement shall not
in any way be affected or impaired thereby and the parties will attempt to agree
upon a valid and enforceable provision which shall be a reasonable substitute
therefor, and upon so agreeing, shall incorporate such substitute provision in
this Agreement.

     4.12 Remedies. In addition to being entitled to exercise all rights
provided herein or granted by law, including recovery of damages, the Purchasers
will be entitled to specific performance of the obligations of the Company under
the Transaction Documents. Each of the Company and the Purchasers agree that
monetary damages may not be adequate compensation for any loss incurred by
reason of any breach of its obligations described in the foregoing sentence and
hereby agrees to waive in any action for specific performance of any such
obligation the defense that a remedy at law would be adequate.

<PAGE>


     4.13 Independent Nature of Purchasers' Obligations and Rights. The
obligations of each Purchaser under any Transaction Document is several and not
joint with the obligations of any other Purchaser, and no Purchaser shall be
responsible in any way for the performance of the obligations of any other
Purchaser under any Transaction Document. Nothing contained herein or in any
Transaction Document, and no action taken by any Purchaser pursuant thereto,
shall be deemed to constitute the Purchasers as a partnership, an association, a
joint venture or any other kind of entity, or create a presumption that the
Purchasers are in any way acting in concert with respect to such obligations or
the transactions contemplated by the Transaction Document. Each Purchaser shall
be entitled to independently protect and enforce its rights, including without
limitation the rights arising out of this Agreement or out of the Transaction
Documents, and it shall not be necessary for any other Purchaser to be joined as
an additional party in any proceeding for such purpose.

                   [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK
                            SIGNATURE PAGES FOLLOWS]


<PAGE>



                  IN WITNESS WHEREOF, the parties hereto have caused this
Securities Purchase Agreement to be duly executed by their respective authorized
signatories as of the date first indicated above.

                                           SAFESCIENCE, INC.


                                           By:__________________________________
                                                Name:
                                                Title:







                   [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK
                     SIGNATURE PAGES FOR PURCHASERS FOLLOWS]


<PAGE>




                         STRONG RIVER INVESTMENTS, INC.



                             By:      _____________________________________
                             Name: Miriam O. Hyman
                             Title: Attorney-in-Fact

                             Purchase Price for Shares:               $3,500,000

                             Number of Shares to be acquired:            242,214

                             Warrant Shares subject to Closing
                             Warrant:                                     54,498

                             Address for Notice:

                             Strong River Investments, Inc.
                             c/o Gonzalez-Ruiz & Aleman (BVI) Limited
                             Wickhams Cay I, Vanterpool Plaza
                             P.O. Box 873
                             Road Town, Tortolla. B.V.I.

                             With a copy to:
                             Robinson Silverman Pearce Aronsohn &
                                Berman LLP
                             1290 Avenue of the Americas
                             New York, NY  10104
                             Facsimile No.:  (212) 541-4630 and (212) 541-1432
                             Attn: Kenneth L. Henderson, Esq. and Eric L. Cohen,
                                    Esq.




<PAGE>



                            MONTROSE INVESTMENTS LTD.



                            By:      _____________________________________
                                     Name:
                                     Title:

                            Purchase Price for Shares:                $3,500,000

                            Number of Shares to be acquired:             242,214
                            Warrant Shares subject to Closing
                            Warrant:                                      54,498

Address for Notice:

                            Montrose Investments Ltd.
                            300 Crescent Court, Suite 700
                            Dallas, TX 75201
                            Facsimile: (214) 758-1221
                            Attn:    Will Rose
                                     Kim Rozman
                            With copies to:
                            Robinson Silverman Pearce Aronsohn &
                               Berman LLP
                            1290 Avenue of the Americas
                            New York, NY  10104
                            Facsimile No.:  (212) 541-4630 and (212) 541-1432
                            Attn:    Kenneth L. Henderson, Esq.
                                     Eric L. Cohen, Esq.

<PAGE>





NEITHER THESE SECURITIES NOR THE SECURITIES INTO WHICH THESE SECURITIES ARE
EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR
THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM
REGISTRATION UNDER SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"),
AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE
EXEMPTION FROM THE REGISTRATION REQUIREMENTS THEREUNDER AND IN COMPLIANCE WITH
APPLICABLE STATE SECURITIES OR BLUE SKY LAWS.

                                SAFESCIENCE, INC.

                                     WARRANT
                                     -------

Warrant No.                                                Dated: March 29, 2000


         SafeScience, Inc., a Nevada corporation (the "Company"), hereby
certifies that, for value received, ___________________., or its registered
assigns ("Holder"), is entitled, subject to the terms set forth below, to
purchase from the Company up to a total of 54,498 shares of common stock, $.01
par value per share (the "Common Stock"), of the Company (each such share, a
"Warrant Share" and all such shares, the "Warrant Shares") at an exercise price
equal to $15.98 per share (as adjusted from time to time as provided in Section
8, the "Exercise Price"), at any time and from time to time from and after the
date hereof and through and including March 29, 2005 (the "Expiration Date"),
and subject to the following terms and conditions:

     1. Registration of Warrant. The Company shall register this Warrant, upon
records to be maintained by the Company for that purpose (the "Warrant
Register"), in the name of the record Holder hereof from time to time. The
Company may deem and treat the registered Holder of this Warrant as the absolute
owner hereof for the purpose of any exercise hereof or any distribution to the
Holder, and for all other purposes, and the Company shall not be affected by
notice to the contrary.

     2. Registration of Transfers and Exchanges.

         (a) The Company shall register the transfer of any portion of this
Warrant in the Warrant Register, upon surrender of this Warrant, with the Form
of Assignment attached hereto duly completed and signed, to the Transfer Agent
or to the Company at its address for notice set forth in Section 12. Upon any
such registration or transfer, a new warrant to purchase Common Stock, in
substantially the form of this Warrant (any such new warrant, a "New Warrant"),
evidencing the portion of this Warrant so transferred shall be issued to the
transferee and a New Warrant evidencing the remaining portion of this Warrant
not so transferred, if any, shall be issued to the transferring Holder. The
acceptance of the New Warrant by the transferee thereof shall be deemed the
acceptance of such transferee of all of the rights and obligations of a holder
of a Warrant.

<PAGE>

         (b) This Warrant is exchangeable, upon the surrender hereof by the
Holder to the office of the Company at its address for notice set forth in
Section 12 for one or more New Warrants, evidencing in the aggregate the right
to purchase the number of Warrant Shares which may then be purchased hereunder.
Any such New Warrant will be dated the date of such exchange.

     3. Duration and Exercise of Warrants.

         (a) This Warrant shall be exercisable by the registered Holder on any
business day before 6:30 P.M., New York City time, at any time and from time to
time on or after the date hereof to and including the Expiration Date. At 6:30
P.M., New York City time on the Expiration Date, the portion of this Warrant not
exercised prior thereto shall be and become void and of no value. Prior to the
Expiration Date, the Company may not call or otherwise redeem this Warrant
without the prior written consent of the Holder.

         (b) Upon surrender of this Warrant, with the Form of Election to
Purchase attached hereto duly completed and signed, to the Company at its
address for notice set forth in Section 12 and upon payment of the Exercise
Price multiplied by the number of Warrant Shares that the Holder intends to
purchase hereunder, in the manner provided hereunder, all as specified by the
Holder in the Form of Election to Purchase, the Company shall promptly (but in
no event later than four (4) business days after the Date of Exercise (as
defined herein)) issue or cause to be issued and cause to be delivered to or
upon the written order of the Holder and in such name or names as the Holder may
designate, a certificate for the Warrant Shares issuable upon such exercise,
free of restrictive legends except (i) either in the event that a registration
statement covering the resale of the Warrant Shares and naming the Holder as a
selling stockholder thereunder is not then effective or the Warrant Shares are
not freely transferable without volume restrictions pursuant to Rule 144(k)
promulgated under the Securities Act of 1933, as amended (the "Securities Act"),
or (ii) if this Warrant shall have been issued pursuant to a written agreement
between the original Holder and the Company, as required by such agreement. Any
person so designated by the Holder to receive Warrant Shares shall be deemed to
have become holder of record of such Warrant Shares as of the Date of Exercise
of this Warrant. The Company shall, upon request of the Holder, if available,
use its best efforts to deliver Warrant Shares hereunder electronically through
the Depository Trust Corporation or another established clearing corporation
performing similar functions.

         A "Date of Exercise" means the date on which the Company shall have
received (i) this Warrant (or any New Warrant, as applicable), with the Form of
Election to Purchase attached hereto (or attached to such New Warrant)
appropriately completed and duly signed, and (ii) payment of the Exercise Price
for the number of Warrant Shares so indicated by the holder hereof to be
purchased.

         (c) This Warrant shall be exercisable, either in its entirety or, from
time to time, for a portion of the number of Warrant Shares. If less than all of
the Warrant Shares which may be purchased under this Warrant are exercised at
any time, the Company shall issue or cause


<PAGE>

to be issued, at its expense, a New Warrant evidencing the right to purchase the
remaining number of Warrant Shares for which no exercise has been evidenced by
this Warrant.

     4. Piggyback Registration Rights. During the Effectiveness Period (as
defined in the Registration Rights Agreement, of even date herewith, between the
Company and the original Holder), the Company may not file any registration
statement with the Securities and Exchange Commission (other than registration
statements of the Company filed on Form S-8 or Form S-4, each as promulgated
under the Securities Act, pursuant to which the Company is registering
securities pursuant to a Company employee benefit plan or pursuant to a merger,
acquisition or similar transaction including supplements thereto, but not
additionally filed registration statements in respect of such securities) at any
time when there is not an effective registration statement covering the resale
of the Warrant Shares and naming the Holder as a selling stockholder thereunder,
unless the Company provides the Holder with not less than 15 days notice of its
intention to file such registration statement and provides the Holder the option
to include any or all of the applicable Warrant Shares therein. The piggyback
registration rights granted to the Holder pursuant to this Section shall
continue until all of the Holder's Warrant Shares have been sold in accordance
with an effective registration statement or upon the Expiration Date. The
Company will pay all registration expenses in connection therewith.

     5. Payment of Taxes. The Company will pay all documentary stamp taxes
attributable to the issuance of Warrant Shares upon the exercise of this
Warrant; provided, however, that the Company shall not be required to pay any
tax which may be payable in respect of any transfer involved in the registration
of any certificates for Warrant Shares or Warrants in a name other than that of
the Holder. The Holder shall be responsible for all other tax liability that may
arise as a result of holding or transferring this Warrant or receiving Warrant
Shares upon exercise hereof.

     6. Replacement of Warrant. If this Warrant is mutilated, lost, stolen or
destroyed, the Company shall issue or cause to be issued in exchange and
substitution for and upon cancellation hereof, or in lieu of and substitution
for this Warrant, a New Warrant, but only upon receipt of evidence reasonably
satisfactory to the Company of such loss, theft or destruction and indemnity, if
requested, satisfactory to it. Applicants for a New Warrant under such
circumstances shall also comply with such other reasonable regulations and
procedures and pay such other reasonable charges as the Company may prescribe.

     7. Reservation of Warrant Shares. The Company covenants that it will at all
times reserve and keep available out of the aggregate of its authorized but
unissued Common Stock, solely for the purpose of enabling it to issue Warrant
Shares upon exercise of this Warrant as herein provided, the number of Warrant
Shares which are then issuable and deliverable upon the exercise of this entire
Warrant, free from preemptive rights or any other actual contingent purchase
rights of persons other than the Holder (taking into account the adjustments and
restrictions of Section 8). The Company covenants that all Warrant Shares that
shall be so issuable and deliverable shall, upon issuance and the payment of the
applicable Exercise Price in


<PAGE>

accordance with the terms hereof, be duly and validly authorized, issued and
fully paid and nonassessable.

     8. Certain Adjustments. The Exercise Price and number of Warrant Shares
issuable upon exercise of this Warrant are subject to adjustment from time to
time as set forth in this Section 8. Upon each such adjustment of the Exercise
Price pursuant to this Section 8, the Holder shall thereafter prior to the
Expiration Date be entitled to purchase, at the Exercise Price resulting from
such adjustment, the number of Warrant Shares obtained by multiplying the
Exercise Price in effect immediately prior to such adjustment by the number of
Warrant Shares issuable upon exercise of this Warrant immediately prior to such
adjustment and dividing the product thereof by the Exercise Price resulting from
such adjustment.

         (a) If the Company, at any time while this Warrant is outstanding, (i)
shall pay a stock dividend (except scheduled dividends paid on outstanding
preferred stock as of the date hereof which contain a stated dividend rate) or
otherwise make a distribution or distributions on shares of its Common Stock or
on any other class of capital stock payable in shares of Common Stock, (ii)
subdivide outstanding shares of Common Stock into a larger number of shares, or
(iii) combine outstanding shares of Common Stock into a smaller number of
shares, the Exercise Price shall be multiplied by a fraction of which the
numerator shall be the number of shares of Common Stock (excluding treasury
shares, if any) outstanding before such event and of which the denominator shall
be the number of shares of Common Stock (excluding treasury shares, if any)
outstanding after such event. Any adjustment made pursuant to this Section shall
become effective immediately after the record date for the determination of
stockholders entitled to receive such dividend or distribution and shall become
effective immediately after the effective date in the case of a subdivision or
combination, and shall apply to successive subdivisions and combinations.

         (b) In case of any reclassification of the Common Stock or any
compulsory share exchange pursuant to which the Common Stock is converted into
other securities, cash or property, then the Holder shall have the right
thereafter to exercise this Warrant only into the shares of stock and other
securities and property receivable upon or deemed to be held by holders of
Common Stock following such reclassification or share exchange, and the Holder
shall be entitled upon such event to receive such amount of securities or
property equal to the amount of Warrant Shares such Holder would have been
entitled to had such Holder exercised this Warrant immediately prior to such
reclassification or share exchange. The terms of any such reclassification or
share exchange shall include such terms so as to continue to give to the Holder
the right to receive the securities or property set forth in this Section 8(b)
upon any exercise following any such reclassification or share exchange.

         (c) If the Company, at any time while this Warrant is outstanding,
shall distribute to all holders of Common Stock (and not to holders of this
Warrant) evidences of its indebtedness or assets or rights or warrants to
subscribe for or purchase any security (excluding those referred to in Sections
8(a), (b) and (d)), then in each such case the Exercise Price shall be
determined by multiplying the Exercise Price in effect immediately prior to the
record date fixed


<PAGE>

for determination of stockholders entitled to receive such distribution by a
fraction of which the denominator shall be the Exercise Price determined as of
the record date mentioned above, and of which the numerator shall be such
Exercise Price on such record date less the then fair market value at such
record date of the portion of such assets or evidence of indebtedness so
distributed applicable to one outstanding share of Common Stock as determined by
the Company's independent certified public accountants that regularly examines
the financial statements of the Company (an "Appraiser").

         (d) Except for (i) the issuance of shares of Common Stock and warrants
to purchase Common Stock for an aggregate purchase price of up to $5,000,000
pursuant to a private placement memorandum dated March 10, 2000 and (ii) the
issuance of shares of Common Stock pursuant to the Adjustable Warrants (as
defined in the Securities Purchase Agreement dated the date hereof to which the
original Holder and the Company are parties), the Company or any subsidiary
thereof, as applicable with respect to Common Stock Equivalents (as defined
below), at any time while this Warrant is outstanding, shall issue shares of
Common Stock or rights, warrants, options or other securities or debt that is
convertible into or exchangeable for shares of Common Stock ("Common Stock
Equivalents"), entitling any person to acquire shares of Common Stock at a price
per share less than the Exercise Price (if the holder of the Common Stock or
Common Stock Equivalent so issued shall at any time, whether by operation of
purchase price adjustments, reset provisions, floating conversion, exercise or
exchange prices or otherwise, or due to warrants, options or rights issued in
connection with such issuance, be entitled to receive shares of Common Stock at
a price less than the Exercise Price, such issuance shall be deemed to have
occurred for less than the Exercise Price), then the Exercise Price shall be
multiplied by a fraction, the numerator of which shall be the number of shares
of Common Stock outstanding immediately prior to the issuance of such Common
Stock or such Common Stock Equivalents plus the number of shares of Common Stock
which the offering price for such shares of Common Stock or Common Stock
Equivalents would purchase at the Exercise Price, and the denominator of which
shall be the sum of the number of shares of Common Stock outstanding immediately
prior to such issuance plus the number of shares of Common Stock so issued or
issuable, provided, that for purposes hereof, all shares of Common Stock that
are issuable upon conversion, exercise or exchange of Common Stock Equivalents
shall be deemed outstanding immediately after the issuance of such Common Stock
Equivalents. Such adjustment shall be made whenever such Common Stock or Common
Stock Equivalents are issued. However, upon the expiration of any Common Stock
Equivalents the issuance of which resulted in an adjustment in the Exercise
Price pursuant to this Section, if any such Common Stock Equivalents shall
expire and shall not have been exercised, the Exercise Price shall immediately
upon such expiration be recomputed and effective immediately upon such
expiration be increased to the price which it would have been (but reflecting
any other adjustments in the Exercise Price made pursuant to the provisions of
this Section after the issuance of such Common Stock Equivalents) had the
adjustment of the Exercise Price made upon the issuance of such Common Stock
Equivalents been made on the basis of offering for subscription or purchase only
that number of shares of the Common Stock actually purchased upon the exercise
of such Common Stock Equivalents actually exercised.

<PAGE>


         (e) In case of any (1) merger or consolidation of the Company with or
into another Person, or (2) sale by the Company of more than one-half of the
assets of the Company (on a book value basis) in one or a series of related
transactions, the Holder shall have the right thereafter to exercise this
Warrant for the shares of stock and other securities, cash and property
receivable upon or deemed to be held by holders of Common Stock following such
merger, consolidation or sale, and the Holder shall be entitled upon such event
or series of related events to receive such amount of securities, cash and
property as the Common Stock for which this Warrant could have been exercised
immediately prior to such merger, consolidation or sales would have been
entitled. The terms of any such merger, sale or consolidation shall include such
terms so as continue to give the Holder the right to receive the securities,
cash and property set forth in this Section upon any conversion or redemption
following such event. This provision shall similarly apply to successive such
events.

         (f) For the purposes of this Section 8, the following clauses shall
also be applicable:

               (i)  Record Date. In case the Company shall take a record of the
                    holders of its Common Stock for the purpose of entitling
                    them (A) to receive a dividend or other distribution payable
                    in Common Stock or in securities convertible or exchangeable
                    into shares of Common Stock, or (B) to subscribe for or
                    purchase Common Stock or securities convertible or
                    exchangeable into shares of Common Stock, then such record
                    date shall be deemed to be the date of the issue or sale of
                    the shares of Common Stock deemed to have been issued or
                    sold upon the declaration of such dividend or the making of
                    such other distribution or the date of the granting of such
                    right of subscription or purchase, as the case may be.

               (ii) Treasury Shares. The number of shares of Common Stock
                    outstanding at any given time shall not include shares owned
                    or held by or for the account of the Company, and the
                    disposition of any such shares shall be considered an issue
                    or sale of Common Stock.

         (g) All calculations under this Section 8 shall be made to the nearest
cent or the nearest 1/100th of a share, as the case may be.

         (h) Whenever the Exercise Price is adjusted pursuant to Section 8(c)
above, the Holder, after receipt of the determination by the Appraiser, shall
have the right to select an additional appraiser (which shall be a nationally
recognized accounting firm), in which case the adjustment shall be equal to the
average of the adjustments recommended by each of the Appraiser and such
appraiser. The Holder shall promptly mail or cause to be mailed to the Company,
a notice setting forth the Exercise Price after such adjustment and setting
forth a brief


<PAGE>

statement of the facts requiring such adjustment. Such adjustment shall become
effective immediately after the record date mentioned above.

         (i) If:

               (i)  the Company shall declare a dividend (or any other
                    distribution) on its Common Stock; or

               (ii) the Company shall declare a special nonrecurring cash
                    dividend on or a redemption of its Common Stock; or

               (iii) the Company shall authorize the granting to all holders of
                    the Common Stock rights or warrants to subscribe for or
                    purchase any shares of capital stock of any class or of any
                    rights; or

               (iv) the approval of any stockholders of the Company shall be
                    required in connection with any reclassification of the
                    Common Stock, any consolidation or merger to which the
                    Company is a party, any sale or transfer of all or
                    substantially all of the assets of the Company, or any
                    compulsory share exchange whereby the Common Stock is
                    converted into other securities, cash or property; or

               (v)  the Company shall authorize the voluntary dissolution,
                    liquidation or winding up of the affairs of the Company,

then the Company shall cause to be mailed to each Holder at their last addresses
as they shall appear upon the Warrant Register, at least 20 calendar days prior
to the applicable record or effective date hereinafter specified, a notice
stating (x) the date on which a record is to be taken for the purpose of such
dividend, distribution, redemption, rights or warrants, or if a record is not to
be taken, the date as of which the holders of Common Stock of record to be
entitled to such dividend, distributions, redemption, rights or warrants are to
be determined or (y) the date on which such reclassification, consolidation,
merger, sale, transfer or share exchange is expected to become effective or
close, and the date as of which it is expected that holders of Common Stock of
record shall be entitled to exchange their shares of Common Stock for
securities, cash or other property deliverable upon such reclassification,
consolidation, merger, sale, transfer, share exchange, dissolution, liquidation
or winding up; provided, however, that the failure to mail such notice or any
defect therein or in the mailing thereof shall not affect the validity of the
corporate action required to be specified in such notice.

     9. Payment of Exercise Price. The Holder shall pay the Exercise Price in
one of the following manners:

         (a) Cash Exercise. The Holder may deliver immediately available funds;
or

<PAGE>

         (b) Cashless Exercise. The Holder may surrender this Warrant to the
Company together with a notice of cashless exercise, in which event the Company
shall issue to the Holder the number of Warrant Shares determined as follows:

                         X = Y [(A-B)/A]
         where:
                         X = the number of Warrant Shares to be issued to the
                         Holder.

                         Y = the number of Warrant Shares with
                         respect to which this Warrant is being
                         exercised.

                         A = the average of the closing sale prices
                         of the Common Stock for the five (5) trading
                         days immediately prior to (but not
                         including) the Date of Exercise.

                         B = the Exercise Price.

For purposes of Rule 144 promulgated under the Securities Act, it is intended,
understood and acknowledged that the Warrant Shares issued in a cashless
exercise transaction shall be deemed to have been acquired by the Holder, and
the holding period for the Warrant Shares shall be deemed to have been
commenced, on the issue date.

     10. Certain Exercise Restrictions

         (a) A Holder may not exercise this Warrant to the extent such exercise
would result in the Holder, together with any affiliate thereof, beneficially
owning (as determined in accordance with Section 13(d) of the Securities
Exchange Act of 1934, as amended (the "Exchange Act") and the rules promulgated
thereunder) in excess of 4.999% of the then issued and outstanding shares of
Common Stock, including shares issuable upon such exercise and held by such
Holder after application of this Section. Since the Holder will not be obligated
to report to the Company the number of shares of Common Stock it may hold at the
time of an exercise hereunder, unless the exercise at issue would result in the
issuance of shares of Common Stock in excess of 4.999% of the then outstanding
shares of Common Stock without regard to any other shares which may be
beneficially owned by the Holder or an affiliate thereof, the Holder shall have
the authority and obligation to determine whether the restriction contained in
this Section will limit any particular exercise hereunder and to the extent that
the Holder determines that the limitation contained in this Section applies, the
determination of which portion of this Warrant is exercisable shall be the
responsibility and obligation of the Holder. If the Holder has delivered a Form
of Election to Purchase for a number of Warrant Shares that, without regard to
any other shares that the Holder or its affiliates may beneficially own, would
result in the issuance in excess of the permitted amount hereunder, the Company
shall notify the Holder of this fact and shall honor the exercise for the
maximum portion of this Warrant permitted to be exercised on such Date of
Exercise in accordance with the periods described herein and, at the option of
the Holder, either keep the portion of the Warrant tendered for exercise in
excess of the permitted amount hereunder for future exercises or return such
excess portion of the Warrant to the Holder.


<PAGE>

The provisions of this Section may be waived by a Holder (but only as to itself
and not to any other Holder) upon not less than 61 days prior notice to the
Company. Other Holders shall be unaffected by any such waiver.

         (b) A Holder may not exercise this Warrant to the extent such exercise
would result in the Holder, together with any affiliate thereof, beneficially
owning (as determined in accordance with Section 13(d) of the Exchange Act and
the rules promulgated thereunder) in excess of 9.999% of the then issued and
outstanding shares of Common Stock, including shares issuable upon such exercise
and held by such Holder after application of this Section. Since the Holder will
not be obligated to report to the Company the number of shares of Common Stock
it may hold at the time of an exercise hereunder, unless the exercise at issue
would result in the issuance of shares of Common Stock in excess of 9.999% of
the then outstanding shares of Common Stock without regard to any other shares
which may be beneficially owned by the Holder or an affiliate thereof, the
Holder shall have the authority and obligation to determine whether the
restriction contained in this Section will limit any particular exercise
hereunder and to the extent that the Holder determines that the limitation
contained in this Section applies, the determination of which portion of this
Warrant is exercisable shall be the responsibility and obligation of the Holder.
If the Holder has delivered a Form of Election to Purchase for a number of
Warrant Shares that, without regard to any other shares that the Holder or its
affiliates may beneficially own, would result in the issuance in excess of the
permitted amount hereunder, the Company shall notify the Holder of this fact and
shall honor the exercise for the maximum portion of this Warrant permitted to be
exercised on such Date of Exercise in accordance with the periods described
herein and, at the option of the Holder, either keep the portion of the Warrant
tendered for exercise in excess of the permitted amount hereunder for future
exercises or return such excess portion of the Warrant to the Holder. The
provisions of this Section may be waived by a Holder (but only as to itself and
not to any other Holder) upon not less than 61 days prior notice to the Company.
Other Holders shall be unaffected by any such waiver.

     11. Fractional Shares. The Company shall not be required to issue or cause
to be issued fractional Warrant Shares on the exercise of this Warrant. The
number of full Warrant Shares which shall be issuable upon the exercise of this
Warrant shall be computed on the basis of the aggregate number of Warrant Shares
purchasable on exercise of this Warrant so presented. If any fraction of a
Warrant Share would, except for the provisions of this Section, be issuable on
the exercise of this Warrant, the Company shall pay an amount in cash equal to
the Exercise Price multiplied by such fraction.

     12. Notices. Any and all notices or other communications or deliveries
hereunder shall be in writing and shall be deemed given and effective on the
earliest of (i) the date of transmission, if such notice or communication is
delivered via facsimile at the facsimile telephone number specified in this
Section prior to 6:30 p.m. (New York City time) on a business day, (ii) the
business day after the date of transmission, if such notice or communication is
delivered via facsimile at the facsimile telephone number specified in this
Section later than 6:30 p.m. (New York City time) on any date and earlier than
11:59 p.m. (New York City time) on such date, (iii) the business day following
the date of mailing, if sent by nationally recognized


<PAGE>

overnight courier service, or (iv) upon actual receipt by the party to whom such
notice is required to be given. The addresses for such communications shall be:
(i) if to the Company, to Park Square Building, 31 St. James Avenue, 8th Floor,
Boston, MA 02116, facsimile: 617-422-0675, attention Chief Financial Officer, or
(ii) if to the Holder, to the Holder at the address or facsimile number
appearing on the Warrant Register or such other address or facsimile number as
the Holder may provide to the Company in accordance with this Section.

     13. Warrant Agent. The Company shall serve as warrant agent under this
Warrant. Upon thirty (30) days' notice to the Holder, the Company may appoint a
new warrant agent. Any corporation into which the Company or any new warrant
agent may be merged or any corporation resulting from any consolidation to which
the Company or any new warrant agent shall be a party or any corporation to
which the Company or any new warrant agent transfers substantially all of its
corporate trust or shareholders services business shall be a successor warrant
agent under this Warrant without any further act. Any such successor warrant
agent shall promptly cause notice of its succession as warrant agent to be
mailed (by first class mail, postage prepaid) to the Holder at the Holder's last
address as shown on the Warrant Register.

     14. Miscellaneous.

         (a) This Warrant shall be binding on and inure to the benefit of the
parties hereto and their respective successors and assigns. This Warrant may be
amended only in writing signed by the Company and the Holder and their
successors and assigns.

         (b) Subject to Section 14(a), above, nothing in this Warrant shall be
construed to give to any person or corporation other than the Company and the
Holder any legal or equitable right, remedy or cause under this Warrant. This
Warrant shall inure to the sole and exclusive benefit of the Company and the
Holder.

         (c) The corporate laws of the State of Nevada shall govern all issues
concerning the relative rights of the Company and its stockholders. All other
questions concerning the construction, validity, enforcement and interpretation
of this Warrant shall be governed by and construed and enforced in accordance
with the internal laws of the State of New York, without regard to the
principles of conflicts of law thereof. The Company and the Holder hereby
irrevocably submit to the exclusive jurisdiction of the state and federal courts
sitting in the City of New York, borough of Manhattan, for the adjudication of
any dispute hereunder or in connection herewith or with any transaction
contemplated hereby or discussed herein, and hereby irrevocably waives, and
agrees not to assert in any suit, action or proceeding, any claim that it is not
personally subject to the jurisdiction of any such court, or that such suit,
action or proceeding is improper. Each of the Company and the Holder hereby
irrevocably waives personal service of process and consents to process being
served in any such suit, action or proceeding by receiving a copy thereof sent
to the Company at the address in effect for notices to it under this instrument
and agrees that such service shall constitute good and sufficient service of
process and notice thereof. Nothing contained herein shall be deemed to limit in
any way any right to serve process in any manner permitted by law.

<PAGE>

         (d) The headings herein are for convenience only, do not constitute a
part of this Warrant and shall not be deemed to limit or affect any of the
provisions hereof.

         (e) In case any one or more of the provisions of this Warrant shall be
invalid or unenforceable in any respect, the validity and enforceability of the
remaining terms and provisions of this Warrant shall not in any way be affected
or impaired thereby and the parties will attempt in good faith to agree upon a
valid and enforceable provision which shall be a commercially reasonable
substitute therefor, and upon so agreeing, shall incorporate such substitute
provision in this Warrant.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK,
                             SIGNATURE PAGE FOLLOWS]


<PAGE>



                  IN WITNESS WHEREOF, the Company has caused this Warrant to be
duly executed by its authorized officer as of the date first indicated above.


                                       SAFESCIENCE, INC.


                                       By:_____________________________________
                                            Name:
                                            Title:


<PAGE>



                          FORM OF ELECTION TO PURCHASE

(To be executed by the Holder to exercise the right to purchase shares of Common
Stock under the foregoing Warrant)

To SafeScience, Inc.

In accordance with the Warrant enclosed with this Form of Election to Purchase,
the undersigned holder hereby exercises the right to purchase _________________
of the shares of Common Stock ("Warrant Shares") of SafeScience, Inc., a Nevada
corporation (the "Company"), evidenced by the attached Warrant (the "Warrant").
Capitalized terms used herein and not otherwise defined shall have the
respective meanings set forth in the Warrant.

         1. Form of Exercise Price. The Holder intends that payment of the
Exercise Price shall be made as:

____________      a "Cash Exercise" with respect to _________________ Warrant
                            Shares; and/or

____________      a "Cashless Exercise" with respect to _______________ Warrant
                           Shares (to the extent permitted by the terms of the
                           Warrant).

         2. Payment of Exercise Price. In the event that the holder has elected
a Cash Exercise with respect to some or all of the Warrant Shares to be issued
pursuant hereto, the holder shall pay the sum of $___________________ to the
Company in accordance with the terms of the Warrant.

         3. Delivery of Warrant Shares. The Company shall deliver to the holder
__________ Warrant Shares in accordance with the terms of the Warrant.

Date: _______________ __, ______



   Name of Registered Holder


By:___________________________
     Name:
     Title:




<PAGE>


                  If the number of shares of Common Stock issuable upon this
exercise shall not be all of the shares of Common Stock which the undersigned is
entitled to purchase in accordance with the enclosed Warrant, the undersigned
requests that a New Warrant (as defined in the Warrant) evidencing the right to
purchase the shares of Common Stock not issuable pursuant to the exercise
evidenced hereby be issued in the name of and delivered to:

                                   (Please print name and address)


Dated: _____________, _____           Name of Holder:


                                      (Print)

                                      (By:)
                                      (Name:)
                                      (Title:)
                                      (Signature must conform in all respects to
                                      name of holder as specified on the face
                                      of the Warrant)


<PAGE>


                               FORM OF ASSIGNMENT

           [To be completed and signed only upon transfer of Warrant]

                  FOR VALUE RECEIVED, the undersigned hereby sells, assigns and
transfers unto ________________________________ the right represented by the
within Warrant to purchase ____________ shares of Common Stock of SafeScience,
Inc. to which the within Warrant relates and appoints ________________ attorney
to transfer said right on the books of SafeScience, Inc. with full power of
substitution in the premises.

Dated:

- ---------------, ----


                                     -------------------------------------
                                     (Signature  must  conform in all  respects
                                     to name of holder as
                                     specified on the face of the Warrant)


                                     -------------------------------------
                                     Address of Transferee

                                     -------------------------------------

                                     -------------------------------------



In the presence of:


- --------------------------




NEITHER THESE  SECURITIES  NOR THE  SECURITIES  INTO WHICH THESE  SECURITIES ARE
EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE  COMMISSION OR
THE  SECURITIES  COMMISSION  OF ANY STATE IN  RELIANCE  UPON AN  EXEMPTION  FROM
REGISTRATION  UNDER THE  SECURITIES  ACT OF 1933,  AS AMENDED  (THE  "SECURITIES
ACT"),  AND,  ACCORDINGLY,  MAY NOT BE OFFERED  OR SOLD  EXCEPT  PURSUANT  TO AN
EFFECTIVE  REGISTRATION  STATEMENT  UNDER THE  SECURITIES  ACT OR PURSUANT TO AN
AVAILABLE  EXEMPTION  FROM  THE  REGISTRATION  REQUIREMENTS  THEREUNDER  AND  IN
COMPLIANCE WITH APPLICABLE STATE SECURITIES OR BLUE SKY LAWS.


                                SAFESCIENCE, INC.

                                     WARRANT
                                     -------

Warrant No. [  ]  Dated: March 29, 2000


         SafeScience,   Inc.,  a  Nevada  corporation  (the  "Company"),  hereby
certifies that, for value received, [ ] or its registered assigns ("Holder"), is
entitled, subject to the terms set forth below, to purchase from the Company the
total  number of shares of common  stock,  $.01 par value per share (the "Common
Stock"), of the Company (each such share, a "Warrant Share" and all such shares,
the "Warrant Shares")  calculated pursuant to Section 3 of this Warrant (subject
to adjustment for certain events as set forth herein) at an exercise price equal
to $.01 per share (as  adjusted  from time to time as provided in Section 8, the
"Exercise Price"),  at the times set forth herein through and including the 40th
Business  Day (as defined in Exhibit A)  following  the Third  Vesting  Date (as
defined herein) (the "Expiration  Date"), and subject to the following terms and
conditions (certain terms used herein are defined in Exhibit A attached hereto):

         1.  Registration  of Warrant.  The Company shall register this Warrant,
upon records to be  maintained  by the Company for that  purpose  (the  "Warrant
Register"),  in the name of the  record  Holder  hereof  from time to time.  The
Company may deem and treat the registered Holder of this Warrant as the absolute
owner hereof for the purpose of any exercise  hereof or any  distribution to the
Holder,  and for all other  purposes,  and the Company  shall not be affected by
notice to the contrary.

         2.  Registration of Transfers.  The Company shall register the transfer
of any portion of this Warrant in the Warrant  Register,  upon surrender of this
Warrant,  with the Form of Assignment attached hereto duly completed and signed,
to the Transfer Agent or to the Company at the address  specified in Section 13.
Upon any such registration or transfer,  a new warrant to purchase Common Stock,
in  substantially  the  form of this  Warrant  (any  such  new  warrant,  a "New
Warrant"), evidencing the portion of this Warrant so transferred shall be issued
to the  transferee and a New Warrant  evidencing  the remaining  portion of this
Warrant not so transferred,  if any, shall be issued to the transferring Holder.
The acceptance of the New Warrant by the transferee  thereof shall be deemed the
acceptance of such  transferee of all of the rights and  obligations of a holder
of a Warrant.

         3.       Duration, Vesting and Exercise.

                  (a) The  vesting  of the  Warrant  Shares  which the Holder is
permitted to acquire pursuant to this Warrant shall occur on the dates set forth
below.  On each such date,  this Warrant  shall vest on a cumulative  basis with
respect to a number of Warrant Shares calculated pursuant to Section 3(b) below.
Only the Warrant  Shares that have vested may be acquired  upon exercise of this
Warrant.

<PAGE>

                           (i)      The first vesting  date (the "First  Vesting
Date") shall be the Effective Date (as defined in Exhibit A), provided, that, at
the Holders  option,  the First  Vesting Date may be delayed up to twelve months
after the Effective Date; provided,  however,  that if the Holder shall not have
provided the Company with notice of its  intention for the First Vesting Date to
occur  prior to the 14th month  anniversary  of the  Effective  Date,  the First
Vesting Date shall occur on such 14th month anniversary of the Effective Date.

                           (ii) The second  vesting  date (the  "Second  Vesting
Date") shall be the 40th Trading Day following the First Vesting Date; and

                           (iii) The third  vesting  date  (the  "Third  Vesting
Date") shall be the 40th Trading Day following the Second Vesting Date.

                  Each of the First Vesting Date, Second Vesting Date, and Third
Vesting Date shall be referred to herein as a Vesting Date.

                  (b) On each Vesting  Date,  this Warrant shall vest and become
exercisable  with  respect  to  the  number  of  Warrant  Shares  calculated  in
accordance with the following formula:

        (Applicable Share Number) x [(Purchase Price - Adjustment Price)]
        -----------------------------------------------------------------
                                Adjustment Price

                  If the number  calculated  in  accordance  with the  foregoing
formula is zero or a negative number, no Warrant Shares shall vest hereunder for
such  Vesting  Date and the Holder shall not be obligated to transfer any shares
of Common Stock to the Company.  In addition,  the Holder shall not be obligated
to transfer  any shares of Common  Stock to the  Company and the number  Warrant
Shares  exercisable  hereunder  which  shall  have  previously  vested  will not
decrease.

                  (c) Notwithstanding anything herein to the contrary, if, after
the  Effective  Date,  the average of the Per Share Market Values (as defined in
Exhibit A) for 20 consecutive  Trading Days is greater than 135% of the Purchase
Price (as  defined  in Exhibit A) (which  number  shall be subject to  equitable
adjustment for stock splits,  recombinations  and similar events),  this Warrant
shall not vest with respect to any additional  Warrant Shares but will remain in
effect as to any Warrant Shares which have vested prior thereto.

                  (d) Notwithstanding anything herein to the contrary, if on any
Vesting Date the  Adjustment  Price shall be less than 70% of the Purchase Price
(the "Floor Price"), then on such Vesting Date: (i) this Warrant shall vest with
respect to the Warrant Shares pursuant to Section 3(a) and (b) hereof, provided,
that the  Adjustment  Price  pursuant to the  formula set forth in Section  3(b)
shall,  exclusively for purposes of this Section 3(d)(i),  equal the Floor Price
(such number of Warrant Shares,  the "Initial  Shares") and (ii) with respect to
the Warrant  Shares whose vesting would result in a vesting of Warrant Shares in
excess of the  Initial  Shares,  the  Company  will have the  option to elect by
written notice (the "Notice")  delivered to the Holder no later than twenty (20)
Trading  Days  prior to the  applicable  Vesting  Date to either  (x) pay to the
Holder,  in cash (the "Cash  Payment"),  within three (3) Trading Days after the
Vesting  Date at issue (the  "Delivery  Date"),  an amount  equal to the product
obtained by multiplying (A) the Adjustment Price and (B) the difference  between
the number of Warrant Shares which would have  otherwise  vested on such Vesting
Date pursuant to Section 3(a) and (b) hereof and the Initial Shares (such number
of Warrant Shares,  the  "Subsequent  Shares") or (y) allow this Warrant to vest
with respect to the Subsequent  Shares.  A failure by the Company to deliver the
Notice to the Holder  pursuant to the terms of this Section shall  constitute an
election  by the  Company  to allow this  Warrant  to vest as to the  Subsequent
Shares  pursuant to the terms hereof.  If the Company shall fail to pay the Cash
Payment in full to the Holder by the third  (3rd)  Trading Day after the Vesting
Date at issue then, at the election of the Holder,  the Company shall either (x)
pay to the Holder  $5,000 per day (in  addition to the Cash  Payment)  until the
Cash Payment and all  additional  payments due hereunder are paid in full or (y)
allow  this  Warrant  to vest  with  respect  to the  number of  Warrant  Shares
calculated in accordance  with the formula set forth in Section 3(b),  provided,
that for purposes of such calculation,  (A) the Adjustment Price shall be deemed
to mean 90% of the average of the four  lowest Per Share  Market  Values  (which
need not occur on


<PAGE>

consecutive  Trading Days) during the 40 consecutive  Trading Days preceding the
Delivery  Date and (B) the  Applicable  Share Number shall be deemed to mean the
Subsequent Shares.

                  (e) Notwithstanding  the foregoing  provisions of this Section
3, at any time during the period between the Closing Date (as defined in Exhibit
A) and  the  Expiration  Date,  within  ten  (10)  Trading  Days  following  the
occurrence of any of the following  events (each, an "Event"),  the Holder shall
have the option to elect,  by  providing  the  Company  with a notice (an "Event
Vesting Notice"), to have this Warrant vest with respect to those Warrant Shares
that have not yet already vested:

                           (i)  upon the occurrence of any of (i) an acquisition
after the date hereof by an  individual or legal entity or "group" (as described
in Rule 13d-5(b)(1)  promulgated  under the Securities  Exchange Act of 1934, as
amended (the "Exchange Act") of in excess of 1/3 of the voting securities of the
Company,  (ii) a  replacement  of  more  than  one-half  of the  members  of the
Company's board of directors which is not approved by those  individuals who are
members  of the  board of  directors  on the date  hereof  in one or a series of
related  transactions,  (iii) the  merger of the  Company  with or into  another
entity,  consolidation or sale of all or substantially  all of the assets of the
Company  in one or a series  of  related  transactions,  unless  following  such
transaction or series of transactions,  the holders of the Company's  securities
prior  to the  first  such  transaction  continue  to hold at  least  2/3 of the
securities  of the  surviving  entity  or  acquirer  of such  assets or (iv) the
execution  by the Company of an  agreement to which the Company is a party or by
which it is bound,  providing for any of the events set forth above in (i), (ii)
or (iii);

                           (ii)     immediately  prior to an  assignment by  the
Company for the benefit of creditors or  commencement  of a voluntary case under
Title 11 of the United  States Code,  or an entering into of an order for relief
in an involuntary  case under Title 11 of the United States Code, or adoption by
the Company of a plan of liquidation or dissolution;

                           (iii) five (5)  Business  Days prior to the  proposed
consummation  with respect to the Company of a Rule 13e-3 transaction as defined
in Rule 13e-3 under the Exchange Act (or, if necessary, such earlier date as the
Company shall  determine in good faith to be required in order for the Holder to
be able to  participate  in such  transaction),  it being agreed that the Holder
will receive actual notice of the 13e-3 Statement filed with the Commission;

                           (iv) For any period of three (3) Trading  Days (which
need  not be  consecutive  Trading  Days)  commencing  on or  after  the date of
issuance  of this  Warrant,  there  shall be no closing  bid price on the Common
Stock on the Nasdaq (as defined in Exhibit A) or a Subsequent Market (as defined
in Exhibit A);

                           (v)    The Common Stock  fails to be listed or quoted
for  trading on the Nasdaq or a  Subsequent  Market or for a period of three (3)
Trading Days (which need not be consecutive Trading Days);

                           (vi)     After the Effective    Date, a   holder   of
Registrable  Securities (as defined in the Registration Rights Agreement) is not
permitted  to  sell   Registrable   Securities   under  the  Underlying   Shares
Registration  Statement (as defined in Exhibit A) for any reason for five (5) or
more days  (whether  or not  consecutive)  provided  the  reason  the  holder of
Registrable  Securities is not permitted to sell  Registrable  Securities is not
due to the transfer of such Registrable  Securities to a person not named in any
effective   Registration  Statement  (as  defined  in  the  Registration  Rights
Agreement);

                           (vii) The Underlying  Shares  Registration  Statement
shall not be declared  effective by the  Commission  on or prior to the 30th day
following  the  Effectiveness  Date  (as  defined  in  the  Registration  Rights
Agreement);

                           (viii)  The  Company  shall  fail for any  reason  to
deliver certificates to a Holder prior to the fifth day after a Date of Exercise
pursuant to and in accordance with Section 4(a);

<PAGE>

                           (ix) The Company shall fail, pursuant to Section 2(a)
of the Registration Rights Agreement,  to register the Registrable Securities on
a Form S-3 when such form becomes  available  (which shall not be later than May
23, 2000); or

                           (x)      The Company  shall  fail or default  in  the
timely  performance of any material  obligation under the Transaction  Documents
and such  failure or default  shall  continue  uncured  for a period of five (5)
Business Days after the date on which notice of such failure or default is first
given to the Company (it being  understood that no prior notice need be provided
in the case of defaults which cannot reasonably be cured within a 5-day period).

                  In the event the Holder delivers an Event Vesting Notice, this
Warrant  shall vest with respect to the number of Warrant  Shares  calculated in
accordance  with the  formula  set forth in  Section  3(b),  provided,  that for
purposes of such  calculation,  (A) the Adjustment Price shall be deemed to mean
the average of the four lowest Per Share Market  Values (which need not occur on
consecutive  Trading Days) during the 40 consecutive  Trading Days preceding the
date of the Event and (B) the  Applicable  Share  Number shall be deemed to mean
(i) prior to the First Vesting Date 100% of the number of shares of Common Stock
purchased by the Holder pursuant to the Purchase Agreement, (ii) after the First
Vesting  Date and  prior to the  Second  Vesting  Date 66 2/3% of the  number of
shares  of  Common  Stock  purchased  by the  Holder  pursuant  to the  Purchase
Agreement;  and  (iii)  after  the  Second  Vesting  Date and prior to the Third
Vesting  Date 33 1/3% of the number of shares of Common  Stock  purchased by the
Holder  pursuant to the  Purchase  Agreement.  After the Third  Vesting Date the
Applicable Share Number shall equal zero.

                  (f) Subject to Sections  3(a) and (b),  this Warrant  shall be
exercisable by the  registered  Holder on any Business Day before 6:30 P.M., New
York City time, at any time and from time to time on or after the date hereof to
and  including  the  Expiration  Date.  At 6:30 P.M.,  New York City time on the
Expiration  Date, the portion of this Warrant not exercised  prior thereto shall
be and become void and of no value.

                  (g) Subject to Sections  3(a) and (b),  this Warrant  shall be
exercisable,  either in its entirety or, from time to time, for a portion of the
number of Warrant  Shares.  If less than all of the Warrant  Shares which may be
purchased  under this Warrant are exercised at any time, the Company shall issue
or cause to be issued,  at its expense,  a New Warrant  evidencing  the right to
purchase the remaining  number of Warrant  Shares for which no exercise has been
evidenced by this Warrant.

         4.       Delivery of Warrant Shares.

                  (a) Upon surrender of this Warrant,  with the Form of Election
to Purchase  attached  hereto duly  completed and signed,  to the Company at its
address  for notice set forth in  Section  12 and upon  payment of the  Exercise
Price  multiplied  by the number of Warrant  Shares  that the Holder  intends to
purchase hereunder,  in the manner provided  hereunder,  all as specified by the
Holder in the Form of Election to Purchase,  the Company shall  promptly (but in
no event later than 3 business  days after the Date of Exercise)  issue or cause
to be  issued  and cause to be  delivered  to or upon the  written  order of the
Holder and in such name or names as the Holder may designate,  a certificate for
the Warrant  Shares  issuable upon such exercise,  free of  restrictive  legends
except (i) either in the event that a registration statement covering the resale
of the Warrant Shares and naming the Holder as a selling stockholder  thereunder
is not then effective or the Warrant Shares are not freely transferable  without
volume restrictions pursuant to Rule 144(k) promulgated under the Securities Act
of 1933, as amended (the  "Securities  Act"), or (ii) if this Warrant shall have
been issued pursuant to a written  agreement between the original Holder and the
Company,  as required by such agreement.  Any person so designated by the Holder
to receive  Warrant  Shares  shall be deemed to have become  holder of record of
such  Warrant  Shares as of the Date of  Exercise of this  Warrant.  The Company
shall, upon request of the Holder, if available, use its best efforts to deliver
Warrant Shares hereunder  electronically through the Depository Trust Company or
another established clearing corporation performing similar functions.

                           A "Date of  Exercise"  means  the  date on which  the
Holders  shall  have  delivered  to the  Company  (i) this  Warrant  (or any New
Warrant, as applicable), with the Form of Election to Purchase attached



<PAGE>

hereto  (or  attached  to such New  Warrant)  appropriately  completed  and duly
signed,  and (ii) payment of the Exercise Price for the number of Warrant Shares
so indicated by the holder hereof to be purchased.

                  (b) If the Company fails to deliver to the Holder  certificate
or certificates  representing the Warrant Shares pursuant to Section 4(a) by the
fourth (4th)  Trading Day after the Date of Exercise,  the Company  shall pay to
such Holder,  in cash,  as liquidated  damages and not as a penalty,  $5,000 for
each day after  such  fourth  (4th)  Trading  Day until  such  certificates  are
delivered.  Nothing  herein  shall  limit the  Holder's  right to pursue  actual
damages for the Company's failure to deliver certificates representing shares of
Common Stock upon  exercise  within the period  specified  herein and the Holder
shall have the right to pursue all remedies  available to it at law or in equity
including,   without  limitation,   a  decree  of  specific  performance  and/or
injunctive relief. The exercise of any such rights shall not prohibit the Holder
from seeking to enforce  damages  pursuant to any other Section  hereof or under
applicable law.

                  (c) In addition to any other  rights  available to the Holder,
if the  Company  fails to  deliver  to the Holder  certificate  or  certificates
representing  the Warrant  Shares  pursuant to Section  4(a) by the fourth (4th)
Trading Day after the Date of Exercise,  and if after such fourth (4th)  Trading
Day the Holder purchases (in an open market  transaction or otherwise) shares of
Common Stock to deliver in  satisfaction  of a sale by the Holder of the Warrant
Shares which the Holder  anticipated  receiving upon such exercise (a "Buy-In"),
then the Company shall pay (1) in cash to the Holder the amount by which (x) the
Holder's total purchase price (including brokerage commissions,  if any) for the
shares  of  Common  Stock  so  purchased  exceeds  (y) the  amount  obtained  by
multiplying  (A) the number of Warrant  Shares that the Company was  required to
deliver pursuant to Section 4(b) to deliver to the Holder in connection with the
exercise  at  issue  by (B)  the  Per  Share  Market  Value  at the  time of the
obligation giving rise to such purchase obligation and (2) deliver to the Holder
the number of shares of Common Stock that would have been issued had the Company
timely complied with its exercise and delivery  obligations  under Section 4(b).
For example,  if the Holder purchases Common Stock having a total purchase price
of $11,000 to cover a Buy-In with respect to an attempted  exercise of shares of
Common Stock with a market price on the date of exercise totaled $10,000,  under
clause (A) of the immediately  preceding  sentence the Company shall be required
to pay the Holder  $1,000.  The Holder shall provide the Company  written notice
indicating the amounts payable to the Holder in respect of the Buy-In.

                  (d) The  Company's  obligations  to issue and deliver  Warrant
Shares in  accordance  with the terms  hereof are  absolute  and  unconditional,
irrespective  of any action or inaction  by the Holder to enforce the same,  any
waiver or consent  with  respect to any  provision  hereof,  the recovery of any
judgment  against any Person or any action to enforce  the same,  or any setoff,
counterclaim,  recoupment,  limitation or termination,  or any breach or alleged
breach by the Holder or any other Person of any obligation to the Company or any
violation  or alleged  violation of law by the Holder or any other  Person,  and
irrespective  of  any  other  circumstance  which  might  otherwise  limit  such
obligation  of the  Company to the Holder in  connection  with the  issuance  of
Warrant  Shares.  If the Company  breaches its  obligations  under this Warrant,
then, in addition to any other  liabilities  the Company may have  hereunder and
under  applicable  law, the Company  shall pay or reimburse the Holder on demand
for all costs of collection and enforcement (including reasonable attorneys fees
and expenses).

         5. Payment of Taxes.  The Company will pay all documentary  stamp taxes
attributable  to the  issuance  of  Warrant  Shares  upon the  exercise  of this
Warrant;  provided,  however,  that the Company shall not be required to pay any
tax which may be payable in respect of any transfer involved in the registration
of any  certificates for Warrant Shares or Warrants in a name other than that of
the Holder. The Holder shall be responsible for all other tax liability that may
arise as a result of holding or transferring  this Warrant or receiving  Warrant
Shares upon exercise hereof.

         6. Replacement of Warrant.  If this Warrant is mutilated,  lost, stolen
or  destroyed,  the Company  shall  issue or cause to be issued in exchange  and
substitution for and upon  cancellation  hereof,  or in lieu of and substitution
for this Warrant,  a New Warrant,  but only upon receipt of evidence  reasonably
satisfactory to the Company of such loss, theft or destruction and customary and
reasonable  indemnity,  if  requested.  Applicants  for a New Warrant under such
circumstances  shall also  comply  with such other  reasonable  regulations  and
procedures and pay such other reasonable charges as the Company may prescribe.


<PAGE>


         7. Reservation of Warrant Shares.  The Company  covenants that it will,
on the date  hereof,  reserve and keep  available  out of the  aggregate  of its
authorized but unissued  Common Stock,  solely for the purpose of enabling it to
issue Warrant Shares upon exercise of this Warrant, a number of shares of Common
Stock that is not less than the number of shares of Common Stock  issuable  upon
exercise of this Warrant on the First Vesting  Date,  assuming for such purposes
that on the First  Vesting  Date:  (A) the  Applicable  Share Number  equals the
entire number of shares of Common Stock  purchased by the original  Holder under
the Purchase  Agreement and (B) the Adjustment Price equals 50% of the Per Share
Market Value on the Trading Day  immediately  preceding  the Closing Date. If on
any date the Warrant Shares issuable upon exercise of this Warrant exceed 85% of
the shares of Common Stock so reserved pursuant to the terms hereof, the Company
will  immediately  increase  the number of shares of Common  Stock  reserved for
issuance  upon  exercise  hereunder to a number equal to the number of shares of
Common Stock then  issuable  upon  exercise of this  Warrant.  All such reserved
shares of Common Stock shall be free from preemptive  rights or any other actual
contingent purchase rights of persons other than the Holder (taking into account
the adjustments and restrictions of Section 8). . The Company covenants that all
Warrant Shares that shall be so issuable and  deliverable  shall,  upon issuance
and the payment of the applicable  Exercise  Price in accordance  with the terms
hereof, be duly and validly authorized, issued and fully paid and nonassessable.

         8. Certain  Adjustments.  The Purchase  Price,  the Exercise  Price and
number of Warrant  Shares  issuable upon exercise of this Warrant are subject to
adjustment  from  time to time as set  forth in this  Section.  Upon  each  such
adjustment  of the Exercise  Price  pursuant to this  Section,  the Holder shall
thereafter prior to the Expiration Date be entitled to purchase, at the Exercise
Price resulting from such  adjustment,  the number of Warrant Shares obtained by
multiplying the Exercise Price in effect immediately prior to such adjustment by
the number of Warrant Shares issuable upon exercise of this Warrant  immediately
prior to such  adjustment and dividing the product thereof by the Exercise Price
resulting from such adjustment.

         (i) If the Company, at any time while this Warrant is outstanding,  (i)
shall pay a stock  dividend  (except  scheduled  dividends  paid on  outstanding
preferred  stock as of the date hereof which contain a stated  dividend rate) or
otherwise make a distribution or  distributions on shares of its Common Stock or
on any other  class of capital  stock  payable in shares of Common  Stock,  (ii)
subdivide  outstanding shares of Common Stock into a larger number of shares, or
(iii)  combine  outstanding  shares of  Common  Stock  into a smaller  number of
shares,  the  Exercise  Price  shall be  multiplied  by a fraction  of which the
numerator  shall be the  number of shares of Common  Stock  (excluding  treasury
shares, if any) outstanding before such event and of which the denominator shall
be the number of shares of Common  Stock  (excluding  treasury  shares,  if any)
outstanding after such event. Any adjustment made pursuant to this Section shall
become  effective  immediately  after the record date for the  determination  of
stockholders  entitled to receive such dividend or distribution and shall become
effective  immediately  after the effective date in the case of a subdivision or
combination, and shall apply to successive subdivisions and combinations.

         (ii)  In  case  of any  reclassification  of the  Common  Stock  or any
compulsory  share exchange  pursuant to which the Common Stock is converted into
other  securities,  cash or  property,  then the  Holder  shall  have the  right
thereafter  to  exercise  this  Warrant  only into the shares of stock and other
securities  and  property  receivable  upon or deemed to be held by  holders  of
Common Stock following such  reclassification,  transfer or share exchange,  and
the  Holder  shall be  entitled  upon  such  event to  receive  such  amount  of
securities or property  equal to the amount of Warrant  Shares such Holder would
have been entitled to had such Holder exercised this Warrant  immediately  prior
to  such   reclassification   or  share   exchange.   The   terms  of  any  such
reclassification or share exchange shall include such terms so as to continue to
give to the Holder the right to receive the  securities or property set forth in
this Section 8(b) upon any exercise following any such reclassification or share
exchange.

         (iii) If the Company,  at any time while this  Warrant is  outstanding,
shall  distribute  to all  holders  of Common  Stock (and not to holders of this
Warrant)  evidences  of its  indebtedness  or assets or  rights or  warrants  to
subscribe for or purchase any security  (excluding those referred to in Sections
8(i),  (ii) and  (iv)),  then in each  such  case the  Exercise  Price  shall be
determined by multiplying the Exercise Price in effect  immediately prior to the
record date fixed for  determination  of  stockholders  entitled to receive such
distribution by a fraction of which the denominator  shall be the Exercise Price
determined  as of the record date  mentioned  above,  and of which the


<PAGE>

numerator  shall be such  Exercise  Price on such record date less the then fair
market  value at such  record  date of the portion of such assets or evidence of
indebtedness so distributed  applicable to one outstanding share of Common Stock
as determined by the Company's  independent  certified  public  accountants that
regularly examines the financial statements of the Company (an "Appraiser").

         (iv) Except for (i) the issuance of shares of Common Stock and warrants
to purchase  Common Stock for an aggregate  purchase  price of up to  $5,000,000
pursuant  to a private  placement  memorandum  dated March 10, 2000 and (ii) the
issuance  of  shares  of Common  Stock  pursuant  to the terms of this and other
identical  warrants issued on the Closing Date, if the Company or any subsidiary
thereof,  as  applicable  with respect to Common Stock  Equivalents  (as defined
below),  at any time while this  Warrant is  outstanding,  shall issue shares of
Common Stock or rights,  warrants,  options or other  securities or debt that is
convertible  into or  exchangeable  for shares of Common  Stock  ("Common  Stock
Equivalents"), entitling any person to acquire shares of Common Stock at a price
per share less than the  Purchase  Price (if the  holder of the Common  Stock or
Common Stock  Equivalent  so issued  shall at any time,  whether by operation of
purchase price adjustments, reset provisions,  floating conversion,  exercise or
exchange  prices or otherwise,  or due to warrants,  options or rights issued in
connection with such issuance,  be entitled to receive shares of Common Stock at
a price less than the  Purchase  Price,  such  issuance  shall be deemed to have
occurred for less than the  Purchase  Price),  then the Purchase  Price shall be
multiplied  by a fraction,  the numerator of which shall be the number of shares
of Common  Stock  outstanding  immediately  prior to the issuance of such Common
Stock or such Common Stock Equivalents plus the number of shares of Common Stock
which the  offering  price  for such  shares  of  Common  Stock or Common  Stock
Equivalents  would purchase at the Purchase Price,  and the denominator of which
shall be the sum of the number of shares of Common Stock outstanding immediately
prior to such  issuance  plus the number of shares of Common  Stock so issued or
issuable,  provided,  that for purposes hereof,  all shares of Common Stock that
are issuable upon conversion,  exercise or exchange of Common Stock  Equivalents
shall be deemed outstanding  immediately after the issuance of such Common Stock
Equivalents.  Such adjustment shall be made whenever such Common Stock or Common
Stock Equivalents are issued.  However,  upon the expiration of any Common Stock
Equivalents  the  issuance of which  resulted in an  adjustment  in the Purchase
Price  pursuant to this  Section,  if any such Common  Stock  Equivalents  shall
expire and shall not have been exercised,  the Purchase Price shall  immediately
upon  such  expiration  be  recomputed  and  effective   immediately  upon  such
expiration  be increased  to the price which it would have been (but  reflecting
any other  adjustments  in the Purchase Price made pursuant to the provisions of
this  Section  after the  issuance of such  Common  Stock  Equivalents)  had the
adjustment  of the  Purchase  Price made upon the  issuance of such Common Stock
Equivalents been made on the basis of offering for subscription or purchase only
that number of shares of the Common Stock  actually  purchased upon the exercise
of such Common Stock Equivalents actually exercised.

         (v) In case of any (1) merger or  consolidation  of the Company with or
into  another  Person,  or (2) sale by the Company of more than  one-half of the
assets of the  Company  (on a book  value  basis) in one or a series of  related
transactions,  the  Holder  shall have the right  thereafter  to  exercise  this
Warrant  for the  shares  of stock  and  other  securities,  cash  and  property
receivable  upon or deemed to be held by holders of Common Stock  following such
merger,  consolidation or sale, and the Holder shall be entitled upon such event
or series of  related  events to receive  such  amount of  securities,  cash and
property as the Common  Stock for which this Warrant  could have been  exercised
immediately  prior to such  merger,  consolidation  or  sales  would  have  been
entitled. The terms of any such merger, sale or consolidation shall include such
terms so as  continue  to give the Holder the right to receive  the  securities,
cash and property set forth in this Section upon any  conversion  or  redemption
following such event.  This provision  shall  similarly apply to successive such
events.

         (vi) For the purposes of this Section 8, the  following  clauses  shall
also be applicable:

                  (i) Record  Date.  In case the Company  shall take a record of
the holders of its Common Stock for the purpose of entitling them (A) to receive
a  dividend  or other  distribution  payable  in Common  Stock or in  securities
convertible or exchangeable into shares of Common Stock, or (B) to subscribe for
or purchase Common Stock or securities  convertible or exchangeable  into shares
of Common  Stock,  then such  record  date shall be deemed to be the date of the
issue or sale of the shares of Common  Stock  deemed to have been issued or sold
upon the  declaration of such dividend or the making of such other  distribution
or the date of the granting of such right of  subscription  or purchase,  as the
case may be.


<PAGE>

                  (ii)  Treasury  Shares.  The number of shares of Common  Stock
outstanding  at any given time shall not include  shares owned or held by or for
the account of the  Company,  and the  disposition  of any such shares  shall be
considered an issue or sale of Common Stock.

         (vii)    All  calculations  under  this  Section 8 shall be made to the
nearest cent or the nearest  1/100th of a share, as the case may be.

         (viii)  Whenever  the  Exercise  Price is adjusted  pursuant to Section
8(iii) above, the Holder,  after receipt of the  determination by the Appraiser,
shall  have the  right to  select  an  additional  appraiser  (which  shall be a
nationally  recognized  accounting  firm), in which case the adjustment shall be
equal to the average of the adjustments recommended by each of the Appraiser and
such  appraiser.  The Holder  shall  promptly  mail or cause to be mailed to the
Company,  a notice  setting forth the Exercise  Price after such  adjustment and
setting forth a brief  statement of the facts  requiring such  adjustment.  Such
adjustment  shall become effective  immediately  after the record date mentioned
above.

         (ix) If (i)  the  Company  shall  declare  a  dividend  (or  any  other
distribution)  on its Common  Stock;  (ii) the Company  shall  declare a special
nonrecurring  cash dividend on or a redemption  of its Common  Stock;  (iii) the
Company  shall  authorize the granting to all holders of the Common Stock rights
or warrants to  subscribe  for or  purchase  any shares of capital  stock of any
class or of any rights;  (iv) the  approval of any  stockholders  of the Company
shall be required in connection with any  reclassification  of the Common Stock,
any  consolidation  or  merger  to which  the  Company  is a party,  any sale or
transfer  of all or  substantially  all of the  assets  of the  Company,  or any
compulsory  share  exchange  whereby the Common  Stock is  converted  into other
securities,  cash or property;  or (v) the Company shall authorize the voluntary
dissolution,  liquidation or winding up of the affairs of the Company,  then the
Company shall cause to be mailed to each Holder at their last  addresses as they
shall appear upon the Warrant  Register,  at least 20 calendar days prior to the
applicable record or effective date hereinafter  specified, a notice stating (x)
the date on which a record  is to be taken  for the  purpose  of such  dividend,
distribution, redemption, rights or warrants, or if a record is not to be taken,
the date as of which the  holders of Common  Stock of record to be  entitled  to
such  dividend,  distributions,   redemption,  rights  or  warrants  are  to  be
determined  or (y)  the  date on  which  such  reclassification,  consolidation,
merger,  sale,  transfer or share  exchange is expected to become  effective  or
close,  and the date as of which it is expected  that holders of Common Stock of
record  shall  be  entitled  to  exchange  their  shares  of  Common  Stock  for
securities,  cash or other  property  deliverable  upon  such  reclassification,
consolidation,  merger, sale, transfer, share exchange, dissolution, liquidation
or winding  up;  provided,  that the  failure to mail such  notice or any defect
therein or in the mailing thereof shall not affect the validity of the corporate
action required to be specified in such notice.

         9. Payment of Exercise  Price.  The Holder shall pay the Exercise Price
in one of the following manners:

                  (a)   Cash  Exercise.  The  Holder  may  deliver   immediately
available funds; or

                  (b) Cashless  Exercise.  The Holder may surrender this Warrant
to the Company together with a notice of cashless  exercise,  in which event the
Company  shall issue to the Holder the number of Warrant  Shares  determined  as
follows:

                                    X = Y [(A-B)/A]where:

                                    X =  the  number  of  Warrant  Shares  to be
                                    issued to the Holder.

                                    Y  =  the  number  of  Warrant  Shares  with
                                    respect  to  which  this  Warrant  is  being
                                    exercised.

                                    A = the average of the  closing  sale prices
                                    of the Common Stock for the five (5) trading
                                    days   immediately   prior   to   (but   not
                                    including)  the Date of Exercise as reported

<PAGE>

                                    by Bloomberg  Information Systems,  Inc. (or
                                    any  successor  to its function of reporting
                                    stock prices).

                                    B = the Exercise Price.

For purposes of Rule 144  promulgated  under the Securities Act, it is intended,
understood  and  acknowledged  that the  Warrant  Shares  issued  in a  cashless
exercise  transaction  shall be deemed to have been acquired by the Holder,  and
the  holding  period  for the  Warrant  Shares  shall  be  deemed  to have  been
commenced, on the issue date.


         10.      Certain Exercise Restrictions

                  (a) A Holder may not exercise  this Warrant to the extent such
exercise  would  result in the  Holder,  together  with any  affiliate  thereof,
beneficially  owning (as  determined  in  accordance  with Section  13(d) of the
Exchange Act and the rules  promulgated  thereunder)  in excess of 4.999% of the
then issued and outstanding  shares of Common Stock,  including  shares issuable
upon such  exercise and held by such Holder after  application  of this Section.
Since the Holder  will not be  obligated  to report to the Company the number of
shares of Common Stock it may hold at the time of an exercise hereunder,  unless
the  exercise at issue would result in the issuance of shares of Common Stock in
excess of 4.999% of the then  outstanding  shares of Common Stock without regard
to any  other  shares  which  may be  beneficially  owned  by the  Holder  or an
affiliate  thereof,  the  Holder  shall have the  authority  and  obligation  to
determine  whether the  restriction  contained  in this  Section  will limit any
particular  exercise hereunder and to the extent that the Holder determines that
the limitation  contained in this Section  applies,  the  determination of which
portion  of  this  Warrant  is  exercisable  shall  be  the  responsibility  and
obligation  of the  Holder.  If the Holder has  delivered  a Form of Election to
Purchase for a number of Warrant Shares that, without regard to any other shares
that the Holder or its  affiliates  may  beneficially  own,  would result in the
issuance in excess of the permitted amount  hereunder,  the Company shall notify
the Holder of this fact and shall honor the exercise for the maximum  portion of
this Warrant  permitted  to be exercised on such Date of Exercise in  accordance
with the periods described herein and, at the option of the Holder,  either keep
the  portion of the Warrant  tendered  for  exercise in excess of the  permitted
amount  hereunder  for future  exercises  or return such  excess  portion of the
Warrant to the Holder.  The provisions of this Section may be waived by a Holder
(but only as to itself and not to any other  Holder)  upon not less than 61 days
prior notice to the  Company.  Other  Holders  shall be  unaffected  by any such
waiver.

                  (b) A Holder may not exercise  this Warrant to the extent such
exercise  would  result in the  Holder,  together  with any  affiliate  thereof,
beneficially  owning (as  determined  in  accordance  with Section  13(d) of the
Exchange Act and the rules  promulgated  thereunder)  in excess of 9.999% of the
then issued and outstanding  shares of Common Stock,  including  shares issuable
upon such  exercise and held by such Holder after  application  of this Section.
Since the Holder  will not be  obligated  to report to the Company the number of
shares of Common Stock it may hold at the time of an exercise hereunder,  unless
the  exercise at issue would result in the issuance of shares of Common Stock in
excess of 9.999% of the then  outstanding  shares of Common Stock without regard
to any  other  shares  which  may be  beneficially  owned  by the  Holder  or an
affiliate  thereof,  the  Holder  shall have the  authority  and  obligation  to
determine  whether the  restriction  contained  in this  Section  will limit any
particular  exercise hereunder and to the extent that the Holder determines that
the limitation  contained in this Section  applies,  the  determination of which
portion  of  this  Warrant  is  exercisable  shall  be  the  responsibility  and
obligation  of the  Holder.  If the Holder has  delivered  a Form of Election to
Purchase for a number of Warrant Shares that, without regard to any other shares
that the Holder or its  affiliates  may  beneficially  own,  would result in the
issuance in excess of the permitted amount  hereunder,  the Company shall notify
the Holder of this fact and shall honor the exercise for the maximum  portion of
this Warrant  permitted  to be exercised on such Date of Exercise in  accordance
with the periods described herein and, at the option of the Holder,  either keep
the  portion of the Warrant  tendered  for  exercise in excess of the  permitted
amount  hereunder  for future  exercises  or return such  excess  portion of the
Warrant to the Holder.  The provisions of this Section may be waived by a Holder
(but only as to itself and not to any other  Holder)  upon not less than 61 days
prior notice to the  Company.  Other  Holders  shall be  unaffected  by any such
waiver.


<PAGE>

                  (c) If the  Company  Stock is then  listed for  trading on the
Nasdaq or the  Nasdaq  National  Market and the  Company  has not  obtained  the
Shareholder  Approval  (as  defined  below),  then the  Company may not issue in
excess of the  product of (i)  3,382,580  (which  number  equals  19.999% of the
shares of Common Stock  outstanding  on the Closing Date and shall be subject to
adjustment pursuant to the anti-dilution  provisions hereof) Warrant Shares upon
exercise of this  Warrant  and (ii) the  quotient  obtained by dividing  (x) the
number of shares of Common Stock  issued and sold to the original  Holder on the
Closing  Date by (y) the number of shares of Common Stock issued and sold by the
Company on the Closing Date (such number of shares, the "Issuable Maximum").  If
any Holder shall no longer hold Warrants then such Holder's remaining portion of
the Issuable Maximum shall be allocated pro-rata among the remaining Holders. If
on any Date of  Exercise  (A) the  Company  Stock is listed  for  trading on the
Nasdaq or the Nasdaq National  Market,  (B) the Exercise Price then in effect is
such that the  aggregate  number of shares of Common  Stock  that  would then be
issuable  upon  exercise in full of this  Warrant,  together  with any shares of
Common Stock  previously  issued upon exercise of this  Warrant,  would equal or
exceed the  Issuable  Maximum,  and (C) the  Company  shall not have  previously
obtained the vote of shareholders,  if any, as may be required by the applicable
rules and  regulations  of the Nasdaq  Stock  Market to approve the  issuance of
shares of Common Stock in excess of the Issuable  Maximum  pursuant to the terms
hereof (the "Shareholder Approval"),  then the Company shall issue to the Holder
a number of shares of Common  Stock  equal to the  Issuable  Maximum  and,  with
respect to the shares  whose  issuance  would result in an issuance of shares of
Common Stock in excess of the Issuable  Maximum,  (the "Excess Warrant Shares"),
the Holder  shall have the option to require  the  Company to either (1) use its
best efforts to obtain the Shareholder  Approval  applicable to such issuance as
soon as  possible,  but in any event no later than 60 days  after  such  request
(such 60th day,  the "Target  Date") or (2) pay to the  Holder,  within five (5)
Trading Days after the request therefor,  an amount in cash equal to the product
of (x) the Excess  Warrant  Shares  multiplied by (y) the closing sales price of
the Common Stock on (a) the Target Date or (b) the Date of Exercise  giving rise
to the obligation to seek Shareholder Approval,  whichever is greater (the "Cash
Payment").  In the event the Holder has  elected to require  the Company to seek
the Shareholder  Approval  pursuant to clause (1) of the  immediately  preceding
sentence and the Company does not obtain the Shareholder Approval on or prior to
the Target  Date,  then,  on the Target  Date,  the  Company  shall pay the Cash
Payment to the  Holder.  If the  Company  fails to pay the Cash  Payment in full
pursuant  to this  Section  within  seven (7) days after the date  payable,  the
Company  will pay  interest on such  amount at a rate of 18% per annum,  or such
lesser  maximum  amount that is permitted to be paid by  applicable  law, to the
Holder,  accruing  daily from the date payable until such amount,  plus all such
interest  thereon,  is paid in full.  The Company and the Holder  understand and
agree that shares of Common Stock issued upon  exercise of this Warrant and then
held by the  Holder  or an  affiliate  thereof  may not cast  votes or be deemed
outstanding for purposes of any vote to obtain the Shareholder Approval.

         12.  Fractional  Shares.  The Company shall not be required to issue or
cause to be issued  fractional  Warrant  Shares on the exercise of this Warrant.
The number of full Warrant  Shares which shall be issuable  upon the exercise of
this Warrant shall be computed on the basis of the  aggregate  number of Warrant
Shares purchasable on exercise of this Warrant so presented.  If any fraction of
a Warrant Share would, except for the provisions of this Section 14, be issuable
on the exercise of this  Warrant,  the Company shall pay an amount in cash equal
to the Exercise Price multiplied by such fraction.

         13. Notices.  Any and all notices or other communications or deliveries
hereunder  shall be in writing and shall be deemed  given and  effective  on the
earliest of (i) the date of  transmission,  if such notice or  communication  is
delivered  via  facsimile at the facsimile  telephone  number  specified in this
Section  prior to 6:30 P.M.  (New York City  time) on a Business  Day,  (ii) the
Business Day after the date of transmission,  if such notice or communication is
delivered  via  facsimile at the facsimile  telephone  number  specified in this
Section  later than 6:30 P.M.  (New York City time) on any date and earlier than
11:59 P.M.  (New York City time) on such date,  (iii) the Business Day following
the date of mailing, if sent by nationally recognized overnight courier service,
or (iv) upon  actual  receipt by the party to whom such notice is required to be
given. The addresses for such communications shall be: (i) if to the Company, to
Park  Square  Building,  31 St.  James  Avenue,  8th  Floor,  Boston,  MA 02116,
facsimile:  617-422-0675,  attention Chief Financial Officer,  or (ii) if to the
Holder,  to the  Holder at the  address or  facsimile  number  appearing  on the
Warrant  Register or such other  address or  facsimile  number as the Holder may
provide to the Company in accordance with this Section.

         14.      Warrant Agent.




<PAGE>


                  (a) The  Company  shall  serve as  warrant  agent  under  this
Warrant.  Upon thirty (30) days' notice to the Holder, the Company may appoint a
new warrant agent.

                  (b) Any corporation  into which the Company or any new warrant
agent may be merged or any corporation resulting from any consolidation to which
the Company or any new  warrant  agent  shall be a party or any  corporation  to
which the Company or any new warrant agent  transfers  substantially  all of its
corporate trust or shareholders  services  business shall be a successor warrant
agent under this Warrant  without any further act.  Any such  successor  warrant
agent shall  promptly  cause  notice of its  succession  as warrant  agent to be
mailed (by first class mail, postage prepaid) to the Holder at the Holder's last
address as shown on the Warrant Register.

         15.      Miscellaneous.

                  (a) This Warrant  shall be binding on and inure to the benefit
of the parties hereto and their respective  successors and assigns. This Warrant
may be amended  only in writing  signed by the  Company and the Holder and their
successors and assigns.

                  (b) Subject to Section 15(a),  above,  nothing in this Warrant
shall be construed to give to any person or  corporation  other than the Company
and the Holder any legal or equitable right, remedy or cause under this Warrant.
This Warrant  shall inure to the sole and  exclusive  benefit of the Company and
the Holder.

                  (c) The corporate laws of the State of Nevada shall govern all
issues concerning the relative rights of the Company and its  stockholders.  All
other  questions   concerning  the  construction,   validity,   enforcement  and
interpretation  of this Warrant  shall be governed by and construed and enforced
in accordance with the internal laws of the State of New York, without regard to
the  principles  of conflicts of law thereof.  The Company and the Holder hereby
irrevocably submit to the exclusive jurisdiction of the state and federal courts
sitting in the City of New York,  borough of Manhattan,  for the adjudication of
any  dispute  hereunder  or in  connection  herewith  or  with  any  transaction
contemplated  hereby or discussed herein,  and hereby  irrevocably  waives,  and
agrees not to assert in any suit, action or proceeding, any claim that it is not
personally  subject to the  jurisdiction  of any such court,  or that such suit,
action or  proceeding  is  improper.  Each of the Company and the Holder  hereby
irrevocably  waives  personal  service of process and consents to process  being
served in any such suit,  action or  proceeding by receiving a copy thereof sent
to the Company at the address in effect for notices to it under this  instrument
and agrees that such service shall  constitute  good and  sufficient  service of
process and notice thereof. Nothing contained herein shall be deemed to limit in
any way any right to serve process in any manner permitted by law.

                  (d) The  headings  herein  are for  convenience  only,  do not
constitute a part of this Warrant and shall not be deemed to limit or affect any
of the provisions hereof.

                  (e) In case any one or more of the  provisions of this Warrant
shall  be  invalid  or   unenforceable   in  any   respect,   the  validity  and
enforceability  of the remaining  terms and provisions of this Warrant shall not
in any way be affected or impaired  thereby and the parties will attempt in good
faith  to  agree  upon a  valid  and  enforceable  provision  which  shall  be a
commercially  reasonable  substitute  therefor,  and  upon  so  agreeing,  shall
incorporate such substitute provision in this Warrant.




                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK,
                             SIGNATURE PAGE FOLLOWS]


<PAGE>




                  IN WITNESS WHEREOF,  the Company has caused this Warrant to be
duly executed by its authorized officer as of the date first indicated above.


                                            SAFESCIENCE, INC.


                                            By:_________________________________
                                               Name:
                                               Title:


<PAGE>



                          FORM OF ELECTION TO PURCHASE

(To be executed by the Holder to exercise the right to purchase shares of Common
Stock under the foregoing Warrant)

To SafeScience, Inc.

         In accordance  with the Warrant  enclosed with this Form of Election to
Purchase,  the  undersigned  holder  hereby  exercises  the  right  to  purchase
_________________   of  the  shares  of  Common  Stock  ("Warrant   Shares")  of
SafeScience,  Inc.,  a Nevada  corporation  (the  "Company"),  evidenced  by the
attached  Warrant  (the  "Warrant").  Capitalized  terms  used  herein  and  not
otherwise defined shall have the respective meanings set forth in the Warrant.

         1. Form of  Exercise  Price.  The Holder  intends  that  payment of the
Exercise Price shall be made as:

                ____________       a "Cash  Exercise" with respect to  _________
                                   Warrant  Shares; and/or

                ____________       a "Cashless  Exercise" with respect to  _____
                                   Warrant Shares  (to  the extent  permitted by
                                   the terms of the Warrant).

         2. Payment of Exercise  Price. In the event that the holder has elected
a Cash Exercise  with respect to some or all of the Warrant  Shares to be issued
pursuant  hereto,  the holder shall pay the sum of  $___________________  to the
Company in accordance with the terms of the Warrant.

         3. Delivery of Warrant Shares.  The Company shall deliver to the holder
__________ Warrant Shares in accordance with the terms of the Warrant.

Date: _______________ __, ______



   Name of Registered Holder


By: __________________________________
     Name:
     Title:


         If the number of shares of Common  Stock  issuable  upon this  exercise
shall not be all of the shares of Common Stock which the undersigned is entitled
to purchase in accordance with the enclosed  Warrant,  the undersigned  requests
that a New Warrant (as defined in the Warrant)  evidencing the right to purchase
the shares of Common Stock not issuable pursuant to the exercise


<PAGE>


evidenced hereby be issued in the name of and delivered to:


- --------------------------------------------------------------------------------
                         (Please print name and address)


- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------

Dated:                     ,             Name of Holder:


                                         (Print)

                                         (By:)
                                         (Name:)
                                         (Title:)
                                         (Signature must conform in all respects
                                         to  name of  holder as specified on the
                                         face of the Warrant)


<PAGE>


                               FORM OF ASSIGNMENT

           [To be completed and signed only upon transfer of Warrant]

         FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers
unto  ________________________________  the  right  represented  by  the  within
Warrant to purchase ____________ shares of Common Stock of SafeScience,  Inc. to
which the within  Warrant  relates  and  appoints  ________________  attorney to
transfer  said  right on the  books of  SafeScience,  Inc.  with  full  power of
substitution in the premises.

Dated:

- ---------------, ----


                                        ---------------------------------------
                                        (Signature   must  conform  in  all
                                        respects  to  name  of  holder  as
                                        specified on the face of the Warrant)


                                        ---------------------------------------
                                        Address of Transferee

                                        ---------------------------------------

                                        ---------------------------------------



In the presence of:


- --------------------------


<PAGE>

                                    Exhibit A
                                    ---------


         (i)  "Adjustment  Price" means the average of the four lowest Per Share
Market Values (which need not occur on  consecutive  Trading Days) during the 40
consecutive Trading Days preceding a Vesting Date.

         (ii)  "Applicable  Share  Number"  means 1/3 of the number of shares of
Common Stock purchased by the Holder pursuant to the Purchase Agreement.

         (iii)  "Business  Day" shall have the meaning set forth in the Purchase
Agreement.

         (iv)  "Closing  Date" shall have the meaning set forth in the  Purchase
Agreement.

         (v) "Commission" means the Securities and Exchange Commission.

         (vi)  "Effective  Date"  the  date  on  which  the  Underlying   Shares
Registration Statement is first declared effective by the Commission.

         (vii) "Nasdaq" means the Nasdaq SmallCap Market.

         (viii) "Per Share Market  Value" means on any  particular  date (a) the
closing bid price per share of the Common Stock on such date on the Nasdaq or on
any  Subsequent  Market on which the Common  Stock is then listed or quoted,  as
reported by  Bloomberg  Information  Services,  Inc.  (or any  successor  entity
succeeding to its function of reporting prices), or if Nasdaq or such Subsequent
Market begins to operate on an extended hours basis,  and does not designate the
closing  bid  price,  then the last bid price at 4:00  p.m.,  Eastern  Time,  as
reported by Bloomberg Information  Services,  Inc., or if there is no such price
on such date,  then the  closing  bid price on the Nasdaq or on such  Subsequent
Market on the date  nearest  preceding  such  date,  as  reported  by  Bloomberg
Information  Services,  Inc. (or any successor entity succeeding to its function
of reporting prices), or (b) if the Common Stock is not then listed or quoted on
the Nasdaq or a Subsequent  Market,  the closing bid price for a share of Common
Stock in the  over-the-counter  market,  as reported by the  National  Quotation
Bureau  Incorporated  or  similar  organization  or  agency  succeeding  to  its
functions of reporting  prices) at the close of business on such date, or (c) if
the  Common  Stock  is not  then  reported  by  the  National  Quotation  Bureau
Incorporated (or similar  organization or agency  succeeding to its functions of
reporting prices),  then the average of the "Pink Sheet" quotes for the relevant
conversion  period,  as  determined  in good faith by the Holder,  or (d) if the
Common  Stock is not then  publicly  traded the fair market  value of a share of
Common Stock as determined by an appraiser selected in good faith by the Holders
of a majority of the applicable Warrant Shares.

         (ix)  "Purchase  Agreement"  means the Securities  Purchase  Agreement,
dated the Closing Date to which the Company and the original  Holder are parties
and pursuant to which this Warrant was issued.

         (x)  "Purchase  Price"  means $[ ]1 (which  number  shall be subject to
equitable adjustment for stock splits, recombinations and similar events).

         (xi)  "Registration  Rights  Agreement" means the  Registration  Rights
Agreement,  dated the Closing  Date hereof to which the Company and the original
Holder are parties.

         (xii)  "Subsequent  Market"  shall  mean  any of  the  New  York  Stock
Exchange, American Stock Exchange, Inc or Nasdaq National Market.

         (xiii)  "Trading  Day"  means  (a) a day on which the  Common  Stock is
traded on the Nasdaq or on the  Subsequent  Market on which the Common  Stock is
then  listed or  quoted,  as the case may be, or (b) if the  Common  Stock s not
listed on the Nasdaq or on a Subsequent  Market, a day on which the Common Stock
is traded in the over-the-counter market, as reported by the OTC Bulletin Board,
or (c) if the Common  Stock is not quoted on the OTC  Bulletin  Board,  a day on
which the Common Stock is quoted in the  over-the-counter  market as reported by
the National  Quotation  Bureau  Incorporated  (or any similar  organization  or
agency  succeeding  its functions of reporting  prices);  provided,  that in the
event that the Common Stock is not listed or quoted as set forth in (a), (b) and
(c) hereof, then Trading Day shall mean a Business Day.

         (xiv)  "Transaction  Documents" shall have the meaning set forth in the
Purchase Agreement.

         (xv) "Underlying Shares Registration  Statement" shall have the meaning
ascribed to it in the Purchase Agreement.



- --------
1 The lesser of (i)110% of the  average of the  closing bid prices of the Common
Stock for four Trading Days preceding the Closing Date and (ii) $16.00.



                          REGISTRATION RIGHTS AGREEMENT
                          -----------------------------


         This Registration Rights Agreement (this "Agreement") is made and
entered into as of March 29, 2000, among SafeScience, Inc., a Nevada corporation
(the "Company"), and the investors signatory hereto (each such investor is a
"Purchaser" and all such investors are, collectively, the "Purchasers").

         This Agreement is made pursuant to the Securities Purchase Agreement,
dated as of the date hereof among the Company and the Purchasers (the "Purchase
Agreement").

                  The Company and the Purchasers hereby agree as follows:

Definitions

         Capitalized terms used and not otherwise defined herein that are
defined in the Purchase Agreement shall have the meanings given such terms in
the Purchase Agreement. As used in this Agreement, the following terms shall
have the following meanings:

         "Adjustable Warrants" shall have the meaning set forth in the Purchase
Agreement.

         "Affiliate" means, with respect to any Person, any other Person that
directly or indirectly controls or is controlled by or under common control with
such Person. For the purposes of this definition, "control," when used with
respect to any Person, means the possession, direct or indirect, of the power to
direct or cause the direction of the management and policies of such Person,
whether through the ownership of voting securities, by contract or otherwise;
and the terms of "affiliated," "controlling" and "controlled" have meanings
correlative to the foregoing.

         "Business Day" " shall have the meaning set forth in the Purchase
Agreement.

         "Closing Date" shall have the meaning set forth in the Purchase
Agreement.

         "Closing Warrants" shall have the meaning set forth in the Purchase
Agreement.

         "Commission" means the Securities and Exchange Commission.

         "Common Stock" means the Company's common stock, $.01 par value, or
such securities that such stock shall hereafter be reclassified into.

         "Effectiveness Date" means the 90th day following the Closing Date.

         "Effectiveness Period" shall have the meaning set forth in Section
2(a).

         "Exchange Act" means the Securities Exchange Act of 1934, as amended.

         "Filing Date" means the 30th day following the Closing Date.

         "Holder" or "Holders" means the holder or holders, as the case may be,
from time to time of Registrable Securities.

<PAGE>


         "Indemnified Party" shall have the meaning set forth in Section 5(c).

         "Indemnifying Party" shall have the meaning set forth in Section 5(c).

         "Losses" shall have the meaning set forth in Section 5(a).

         "Person" means an individual or a corporation, partnership, trust,
incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or political subdivision
thereof) or other entity of any kind.

         "Proceeding" means an action, claim, suit, investigation or proceeding
(including, without limitation, an investigation or partial proceeding, such as
a deposition), whether commenced or threatened.

         "Prospectus" means the prospectus included in the Registration
Statement (including, without limitation, a prospectus that includes any
information previously omitted from a prospectus filed as part of an effective
registration statement in reliance upon Rule 430A promulgated under the
Securities Act), as amended or supplemented by any prospectus supplement, with
respect to the terms of the offering of any portion of the Registrable
Securities covered by the Registration Statement, and all other amendments and
supplements to the Prospectus, including post-effective amendments, and all
material incorporated by reference or deemed to be incorporated by reference in
such Prospectus.

         "Registrable Securities" means (i) the Shares, (ii) the shares of
Common Stock issuable upon exercise in full of the Warrants and (iii) any shares
of capital stock issued or issuable with respect to the Shares or the shares of
Common Stock issuable upon exercise of the Warrants as a result of any stock
split, stock dividend, recapitalization, exchange or similar event or otherwise,
without regard to any limitations on exercises of the Warrants.

         "Registration Statement" means the registration statement and any
additional registration statements contemplated by Section 2(a), including (in
each case) the Prospectus, amendments and supplements to such registration
statement or Prospectus, including pre- and post-effective amendments, all
exhibits thereto, and all material incorporated by reference or deemed to be
incorporated by reference in such registration statement.

         "Rule 144" means Rule 144 promulgated by the Commission pursuant to the
Securities Act, as such Rule may be amended from time to time, or any similar
rule or regulation hereafter adopted by the Commission having substantially the
same effect as such Rule.

         "Rule 415" means Rule 415 promulgated by the Commission pursuant to the
Securities Act, as such Rule may be amended from time to time, or any similar
rule or regulation hereafter adopted by the Commission having substantially the
same effect as such Rule.

         "Rule 424" means Rule 424 promulgated by the Commission pursuant to the
Securities Act, as such Rule may be amended from time to time, or any similar
rule or regulation hereafter adopted by the Commission having substantially the
same effect as such Rule.


<PAGE>

         "Securities Act" means the Securities Act of 1933, as amended, and the
rules and regulations promulgated thereunder.

         "Shares" means the shares of Common Stock issued to the Purchasers on
the Closing Date pursuant to the Purchase Agreement.

         "Special Counsel" means one special counsel to all of the Holders, for
which the Holders will be reimbursed by the Company pursuant to Section 4.

         "Vesting Date" shall have the meaning set forth in the Adjustable
Warrants.

         "Warrants" means the Closing Warrants and the Adjustable Warrants.

Shelf Registration

(a) On or prior to the Filing Date, the Company shall prepare and file with the
Commission a "Shelf" Registration Statement covering the resale of all
Registrable Securities for an offering to be made on a continuous basis pursuant
to Rule 415. The Registration Statement shall be on Form S-3 (except if the
Company is not then eligible to register for resale the Registrable Securities
on Form S-3, in which case such registration shall be on another appropriate
form in accordance herewith as set forth in this section) and shall contain
(except if otherwise directed by the Holders) the "Plan of Distribution"
attached hereto as Annex A. The Company shall use its best efforts to cause the
Registration Statement to be declared effective under the Securities Act as
promptly as possible after the filing thereof, but in any event prior to the
Effectiveness Date, and shall use its best efforts to keep such Registration
Statement continuously effective under the Securities Act until the date which
is two years after the date that such Registration Statement is declared
effective by the Commission or such earlier date when all Registrable Securities
covered by such Registration Statement have been sold or may be sold without
volume restrictions pursuant to Rule 144(k) (the "Effectiveness Period"),
provided, that the Company shall not be deemed to have used its best efforts to
keep the Registration Statement effective during the Effectiveness Period if it
voluntarily takes any action that would result in the Holders not being able to
sell the Registrable Securities covered by such Registration Statement during
the Effectiveness Period, unless such action is required under applicable law or
the Company has filed a post-effective amendment to the Registration Statement
and the Commission has not declared it effective. In the event that Form S-3 is
not available for the registration of the resale of Registrable Securities
hereunder, the Company shall (i) register the resale of the Registrable
Securities on another appropriate form and (ii) register the resale of the
Registrable Securities on Form S-3 as soon as such form is available(which shall
not be later than May 23, 2000), provided, that the Company shall maintain the
effectiveness of the Registration Statement then in effect until such time as a
Registration Statement on Form S-3 covering the Registrable Securities has been
declared effective by the Commission.

(b) In order to account for the fact that the number of shares of Common Stock
that are issuable upon exercise of the Adjustable Warrants is determined in part
upon the market price of the Common Stock on a Vesting Date, the initial
Registration Statement to be filed hereunder shall include (but not be limited
to) a number of shares of Common Stock equal to no less than the sum of (i) the
number of shares issuable upon exercise of the Adjustable


<PAGE>

Warrants on the First Vesting Date (as defined in the Adjustable Warrants)
assuming, for the purposes of this subsection that, on the First Vesting Date:
(A) the Adjustment Price (as defined in the Adjustable Warrants) is 50% of the
Per Share Market Value for the Trading Day immediately preceding the Closing
Date or the Trading Day immediately preceding the Filing Date, whichever is
greater, and (B) the Applicable Share Number (as defined in the Adjustable
Warrants) equals the entire number of Shares purchased under the Purchase
Agreement, (ii) the number of shares issuable upon exercise in full of the
Closing Warrants and (iii) the Shares.

(c) In the event the number of shares available under a Registration Statement
filed pursuant to Section 2(a) is insufficient to cover all of the Registrable
Securities which such Registration Statement is required to cover, the Company
shall file a new Registration Statement (on the short form available therefor,
if applicable), so as to cover at least that number of shares of Common Stock
equal to the sum of (x) 200% of the number of shares issuable upon exercise of
the Adjustable Warrants (without regard to any limitations on exercise) as of
the date immediately preceding the date such amendment or new Registration
Statement is filed with the Commission, plus (y) the number of shares of Common
Stock issuable upon exercise of the Closing Warrants (without regard to any
limitations on exercise) as of the date immediately preceding the date such or
new Registration Statement is filed with the Commission, plus (z) the number of
Registrable Securities held by the Purchasers as of the date immediately
preceding the date on which such or new Registration Statement is filed with the
Commission (assuming such Registrable Securities are not already registered
under an effective Registration Statement previously filed by the Company with
the Commission), in each case, as soon as practicable, but in any event not
later than fifteen (15) business days after the necessity therefor arises. The
Company shall cause such new Registration Statement to become effective as soon
as practicable following the filing thereof but, in any event, no later than the
60th day after the necessity therefor arises. For purposes of the foregoing
provision, the number of shares available under a Registration Statement shall
be deemed insufficient to cover all of the Registrable Securities if the number
of Registrable Securities issued or issuable upon exercise of the Warrants
covered by such Registration Statement is greater than the sum of (a) the
quotient determined by dividing (i) the number of shares of Common Stock
available for resale under the Registration Statement to cover shares issued or
issuable upon exercise of the Adjustable Warrants by (ii) 1.5 and (b) the number
of shares of Common Stock available for resale under the Registration Statement
to cover shares issued or issuable upon exercise of the Closing Warrants. For
purposes of the calculation set forth in the foregoing sentence, any
restrictions on the exercise of the Warrants shall be disregarded and such
calculation shall assume that the Warrants are then exercisable for, shares of
Common Stock at the then prevailing Exercise Price (as defined in the applicable
Warrants).

(d) If (a) the initial Registration Statement is not filed on or prior to the
Filing Date (if the Company files such Registration Statement without affording
the Holder the opportunity to review and comment on the same as required by
Section 3(a) hereof, the Company shall not be deemed to have satisfied this
clause (a)), or (b) the Company fails to file with the Commission a request for
acceleration in accordance with Rule 461 promulgated under the Securities Act,
within five days of the date that the Company is notified (orally or in writing,
whichever is earlier) by the Commission that a Registration Statement will not
be "reviewed," or not subject to further review, or (c) the initial Registration
Statement filed hereunder is not declared effective by the Commission on or
prior to the Effectiveness Date, or (d) after a


<PAGE>

Registration Statement is filed with and declared effective by the Commission,
such Registration Statement ceases to be effective as to all Registrable
Securities required to be registered per clause (b) of this Section 2(d) at any
time prior to the expiration of the Effectiveness Period without being succeeded
within fifteen days by an amendment to such Registration Statement or by a
subsequent Registration Statement filed within 60 days with and declared
effective by the Commission, or (e) the Common Stock shall be delisted or
suspended from trading on the Nasdaq SmallCap Market ("NASDAQ") or on the New
York Stock Exchange, American Stock Exchange or the Nasdaq National Market
(each, a "Subsequent Market") for more than three days (which need not be
consecutive days), or (f) the exercise rights of the Holders pursuant to the
Warrants are suspended for any reason, or (g) an amendment to a Registration
Statement is not filed by the Company with the Commission within ten days of the
Commission's notifying the Company that such amendment is required in order for
such Registration Statement to be declared effective (any such failure or breach
being referred to as an "Event," and for purposes of clauses (a), (c), (f) the
date on which such Event occurs, or for purposes of clause (b) the date on which
such five day period is exceeded, or for purposes of clauses (d) and (g) the
date which such 15 or 10 day-period is exceeded, respectively, or for purposes
of clause (e) the date on which such three day-period is exceeded, being
referred to as "Event Date"), then, in any such case, as partial relief for the
damages suffered therefrom by the Holder (which remedy shall not be exclusive of
any other remedies available at law or in equity), the Company shall on the
Event Date and on each monthly anniversary thereof until the triggering Event is
cured, pay to the Holder an amount in cash, as liquidated damages for the
estimated cost to the Holders of not having liquid securities in the time
contemplated by the Transaction Documents and not as a penalty, equal to 1.5% of
the purchase price paid by such Holder for its Shares pursuant to the Purchase
Agreement. If the applicable Event has not been cured by the 180th day following
the Event Date, on the 180th day following the Event Date and each monthly
anniversary thereof until the applicable Event is cured, the Company shall pay
to each Holder 5.0% of the purchase price paid by such Holder for its Shares
pursuant to the Purchase Agreement, in cash, as liquidated damages and not as a
penalty. The payments to which the Holders shall be entitled pursuant to this
Section are referred to herein as "Registration Delay Payments." Registration
Delay Payments shall be calculated on a cumulative basis and paid within five
(5) Business Days of (i) the Event Date and (ii) each monthly anniversary
thereof. The liquidated damages shall apply on a pro-rata basis for any portion
of a month prior to the cure of an Event. If the Company fails to make
Registration Delay Payments in a timely manner, such Registration Delay Payments
shall bear interest at the rate of 2.0% per month (or the maximum rate permitted
by law), pro-rated for partial months, until paid in full.

Registration Procedures
- -----------------------

         In connection with the Company's registration obligations hereunder,
the Company shall:

(e)  Not less than five Business Days prior to the filing of the Registration
Statement or any related Prospectus or less than two Business Days prior to the
filing of any amendment or supplement thereto (including any document that would
be incorporated or deemed to be incorporated therein by reference), the Company
shall, (i) furnish to the Holders and their Special Counsel copies of all such
documents proposed to be filed, which documents (other than those incorporated
or deemed to be incorporated by reference) will be subject to the review of such
Holders and their Special Counsel, and (ii) cause its officers and directors,

<PAGE>

counsel and independent certified public accountants to respond to such
inquiries as shall be necessary, in the reasonable opinion of respective counsel
to such to conduct a reasonable investigation within the meaning of the
Securities Act. The Company shall not file the Registration Statement or any
such Prospectus or any amendments or supplements thereto to which the Holders of
a majority of the Registrable Securities and their Special Counsel shall
reasonably object. The Holders and their Special Counsel shall have 5 Business
Days in the case of the Registration Statement or any related Prospectus or 2
Business Days in the case of any amendment or supplement thereto to which they
may reasonably object.

(f) (i) Prepare and file with the Commission such amendments, including
post-effective amendments, to the Registration Statement and the Prospectus used
in connection therewith as may be necessary to keep the Registration Statement
continuously effective as to the applicable Registrable Securities for the
Effectiveness Period and prepare and file with the Commission such additional
Registration Statements in order to register for resale under the Securities Act
all of the Registrable Securities; (ii) cause the related Prospectus to be
amended or supplemented by any required Prospectus supplement, and as so
supplemented or amended to be filed pursuant to Rule 424; (iii) respond as
promptly as reasonably possible, and in any event within ten Business Days, to
any comments received from the Commission with respect to the Registration
Statement or any amendment thereto and as promptly as reasonably possible
provide the Holders true and complete copies of all correspondence from and to
the Commission relating to the Registration Statement; and (iv) comply in all
material respects with the provisions of the Securities Act and the Exchange Act
with respect to the disposition of all Registrable Securities covered by the
Registration Statement during the applicable period in accordance with the
intended methods of disposition by the Holders thereof set forth in the
Registration Statement as so amended or in such Prospectus as so supplemented.

(g) [Intentionally left blank]

(h) Notify the Holders of Registrable Securities to be sold and their Special
Counsel as promptly as reasonably possible (and, in the case of (i)(A) below,
not less than five Business Days prior to such filing) and (if requested by any
such Person) confirm such notice in writing no later than one Business Day
following the day (i)(A) when a Prospectus or any Prospectus supplement or
post-effective amendment to the Registration Statement is proposed to be filed;
(B) when the Commission notifies the Company whether there will be a "review" of
such Registration Statement and whenever the Commission comments in writing on
such Registration Statement (the Company shall provide true and complete copies
thereof and all written responses thereto to each of the Holders); and (C) with
respect to the Registration Statement or any post-effective amendment, when the
same has become effective; (ii) of any request by the Commission or any other
Federal or state governmental authority for amendments or supplements to the
Registration Statement or Prospectus or for additional information; (iii) of the
issuance by the Commission of any stop order suspending the effectiveness of the
Registration Statement covering any or all of the Registrable Securities or the
initiation of any Proceedings for that purpose; (iv) if at any time any of the
representations and warranties of the Company contained in any agreement
contemplated hereby ceases to be true and correct in all material respects; (v)
of the receipt by the Company of any notification with respect to the suspension
of the qualification or exemption from qualification of any of the Registrable
Securities for sale in any jurisdiction, or the initiation or threatening of any
Proceeding for such


<PAGE>

purpose; and (vi) of the occurrence of any event or passage of time that makes
the financial statements included in the Registration Statement ineligible for
inclusion therein or any statement made in the Registration Statement or
Prospectus or any document incorporated or deemed to be incorporated therein by
reference untrue in any material respect or that requires any revisions to the
Registration Statement, Prospectus or other documents so that, in the case of
the Registration Statement or the Prospectus, as the case may be, it will not
contain any untrue statement of a material fact or omit to state any material
fact required to be stated therein or necessary to make the statements therein,
in light of the circumstances under which they were made, not misleading.

(i) Use its best efforts to avoid the issuance of, or, if issued, obtain the
withdrawal of (i) any order suspending the effectiveness of the Registration
Statement, or (ii) any suspension of the qualification (or exemption from
qualification) of any of the Registrable Securities for sale in any
jurisdiction, at the earliest practicable moment.

(j) Furnish to each Holder and their Special Counsel, without charge, at least
one conformed copy of each Registration Statement and each amendment thereto,
including financial statements and schedules, all documents incorporated or
deemed to be incorporated therein by reference, and all exhibits to the extent
requested by such Person (including those previously furnished or incorporated
by reference) promptly after the filing of such documents with the Commission.

(k) Promptly deliver to each Holder and their Special Counsel, without charge,
as many copies of the Prospectus or Prospectuses (including each form of
prospectus) and each amendment or supplement thereto as such Persons may
reasonably request. Upon effectiveness of the Registration Statement, the
Company hereby consents to the use of such Prospectus and each amendment or
supplement thereto by each of the selling Holders in connection with the
offering and sale of the Registrable Securities covered by such Prospectus and
any amendment or supplement thereto.

(l) Prior to any public offering of Registrable Securities, use its best efforts
to register or qualify or cooperate with the selling Holders and their Special
Counsel in connection with the registration or qualification (or exemption from
such registration or qualification) of such Registrable Securities for offer and
sale under the securities or Blue Sky laws of such jurisdictions within the
United States as any Holder requests in writing, to keep each such registration
or qualification (or exemption therefrom) effective during the Effectiveness
Period and to do any and all other acts or things necessary or advisable to
enable the disposition in such jurisdictions of the Registrable Securities
covered by a Registration Statement; provided, that the Company shall not be
required to qualify generally to do business in any jurisdiction where it is not
then so qualified or subject the Company to any material tax in any such
jurisdiction where it is not then so subject.

(m) Cooperate with the Holders to facilitate the timely preparation and delivery
of certificates representing Registrable Securities to be delivered to a
transferee pursuant to a Registration Statement, which certificates shall be
free, to the extent permitted by the Purchase Agreement, of all restrictive
legends, and to enable such Registrable Securities to be in such denominations
and registered in such names as any such Holders may request.


<PAGE>


(n) Upon the occurrence of any event contemplated by Section 3(d)(vi), as
promptly as reasonably possible, prepare a supplement or amendment, including a
post-effective amendment, to the Registration Statement or a supplement to the
related Prospectus or any document incorporated or deemed to be incorporated
therein by reference, and file any other required document so that, as
thereafter delivered, neither the Registration Statement nor such Prospectus
will contain an untrue statement of a material fact or omit to state a material
fact required to be stated therein or necessary to make the statements therein,
in light of the circumstances under which they were made, not misleading.

(o) Comply with all applicable rules and regulations of the Commission.

(p) The Company may require each selling Holder to furnish to the Company a
certified statement as to the number of shares of Common Stock beneficially
owned by such Holder and, if requested by the Commission, the controlling person
thereof.

Registration Expenses. All fees and expenses incident to the performance of or
compliance with this Agreement by the Company shall be borne by the Company
whether or not any Registrable Securities are sold pursuant to the Registration
Statement. The fees and expenses referred to in the foregoing sentence shall
include, without limitation, (i) all registration and filing fees (including,
without limitation, fees and expenses (A) with respect to filings required to be
made with the NASDAQ and any Subsequent Market on which the Common Stock is then
listed for trading, and (B) in compliance with state securities or Blue Sky laws
(including, without limitation, fees and disbursements of counsel for the
Holders in connection with Blue Sky qualifications or exemptions of the
Registrable Securities and determination of the eligibility of the Registrable
Securities for investment under the laws of such jurisdictions as the Holders of
a majority of Registrable Securities may designate)), (ii) printing expenses
(including, without limitation, expenses of printing certificates for
Registrable Securities and of printing prospectuses if the printing of
prospectuses is requested by the holders of a majority of the Registrable
Securities included in the Registration Statement), (iii) messenger, telephone
and delivery expenses, (iv) fees and disbursements of counsel for the Company
and Special Counsel for the Holders (in the case of the latter, up to a maximum
of $7,500), (v) Securities Act liability insurance, if the Company so desires
such insurance, and (vi) fees and expenses of all other Persons retained by the
Company in connection with the consummation of the transactions contemplated by
this Agreement. In addition, the Company shall be responsible for all of its
internal expenses incurred in connection with the consummation of the
transactions contemplated by this Agreement (including, without limitation, all
salaries and expenses of its officers and employees performing legal or
accounting duties), the expense of any annual audit and the fees and expenses
incurred in connection with the listing of the Registrable Securities on any
securities exchange as required hereunder.

Indemnification

(q)  Indemnification by the Company. The Company shall, notwithstanding any
termination of this Agreement, indemnify and hold harmless each Holder, the
officers, directors, agents, brokers (including brokers who offer and sell
Registrable Securities as principal as a result of a pledge or any failure to
perform under a margin call of Common Stock), investment advisors and employees
of each of them, each Person who controls any such Holder


<PAGE>

(within the meaning of Section 15 of the Securities Act or Section 20 of the
Exchange Act) and the officers, directors, agents and employees of each such
controlling Person, to the fullest extent permitted by applicable law, from and
against any and all losses, claims, damages, liabilities, costs (including,
without limitation, costs of preparation and attorneys' fees) and expenses
(collectively, "Losses"), as incurred, arising out of or relating to any untrue
or alleged untrue statement of a material fact contained in the Registration
Statement, any Prospectus or any form of prospectus or in any amendment or
supplement thereto or in any preliminary prospectus, or arising out of or
relating to any omission or alleged omission of a material fact required to be
stated therein or necessary to make the statements therein (in the case of any
Prospectus or form of prospectus or supplement thereto, in light of the
circumstances under which they were made) not misleading, except to the extent,
but only to the extent, that (1) such untrue statements or omissions are based
solely upon information regarding such Holder furnished in writing to the
Company by such Holder expressly for use therein, or to the extent that such
information relates to such Holder or such Holder's proposed method of
distribution of Registrable Securities and was reviewed and expressly approved
in writing by such Holder expressly for use in the Registration Statement, such
Prospectus or such form of Prospectus or in any amendment or supplement thereto
or (2) in the case of an occurrence of an event of the type specified in Section
3(d)(ii)-(vi), the use by such Holder of an outdated or defective Prospectus
after the Company has notified such Holder in writing that the Prospectus is
outdated or defective and prior to the receipt by such Holder of the Advice
contemplated in Section 6(e). The Company shall notify the Holders promptly of
the institution, threat or assertion of any Proceeding of which the Company is
aware in connection with the transactions contemplated by this Agreement.

(r) Indemnification by Holders. Each Holder shall, severally and not jointly,
indemnify and hold harmless the Company, its directors, officers, agents and
employees, each Person who controls the Company (within the meaning of Section
15 of the Securities Act and Section 20 of the Exchange Act), and the directors,
officers, agents or employees of such controlling Persons, to the fullest extent
permitted by applicable law, from and against all Losses (as determined by a
court of competent jurisdiction in a final judgment not subject to appeal or
review) arising solely out of or based solely upon any untrue statement of a
material fact contained in the Registration Statement, any Prospectus, or any
form of prospectus, or in any amendment or supplement thereto, or arising solely
out of or based solely upon any omission of a material fact required to be
stated therein or necessary to make the statements therein not misleading to the
extent, but only to the extent, that such untrue statement or omission is
contained in any information so furnished in writing by such Holder to the
Company specifically for inclusion in the Registration Statement or such
Prospectus or to the extent that such information relates to such Holder or such
Holder's proposed method of distribution of Registrable Securities and was
reviewed and expressly approved in writing by such Holder expressly for use in
the Registration Statement, such Prospectus or such form of Prospectus, or in
any amendment or supplement thereto. In no event shall the liability of any
selling Holder hereunder be greater in amount than the dollar amount of the net
proceeds received by such Holder upon the sale of the Registrable Securities
giving rise to such indemnification obligation.

(s) Conduct of Indemnification Proceedings. If any Proceeding shall be brought
or asserted against any Person entitled to indemnity hereunder (an "Indemnified
Party"), such Indemnified Party shall promptly notify the Person from whom
indemnity is sought (the "Indemnifying Party") in writing, and the Indemnifying
Party shall assume the defense thereof,


<PAGE>

including the employment of counsel reasonably satisfactory to the Indemnified
Party and the payment of all fees and expenses incurred in connection with
defense thereof; provided, that the failure of any Indemnified Party to give
such notice shall not relieve the Indemnifying Party of its obligations or
liabilities pursuant to this Agreement, except (and only) to the extent that it
shall be finally determined by a court of competent jurisdiction (which
determination is not subject to appeal or further review) that such failure
shall have proximately and materially adversely prejudiced the Indemnifying
Party.

An Indemnified Party shall have the right to employ separate counsel in any such
Proceeding and to participate in the defense thereof, but the fees and expenses
of such counsel shall be at the expense of such Indemnified Party or Parties
unless: (1) the Indemnifying Party has agreed in writing to pay such fees and
expenses; or (2) the Indemnifying Party shall have failed promptly to assume the
defense of such Proceeding and to employ counsel reasonably satisfactory to such
Indemnified Party in any such Proceeding; or (3) the named parties to any such
Proceeding (including any impleaded parties) include both such Indemnified Party
and the Indemnifying Party, and such Indemnified Party shall have been advised
by counsel that a conflict of interest is likely to exist if the same counsel
were to represent such Indemnified Party and the Indemnifying Party (in which
case, if such Indemnified Party notifies the Indemnifying Party in writing that
it elects to employ separate counsel at the expense of the Indemnifying Party,
the Indemnifying Party shall not have the right to assume the defense thereof
and such counsel shall be at the expense of the Indemnifying Party). The
Indemnifying Party shall not be liable for any settlement of any such Proceeding
effected without its written consent, which consent shall not be unreasonably
withheld. No Indemnifying Party shall, without the prior written consent of the
Indemnified Party, effect any settlement of any pending Proceeding in respect of
which any Indemnified Party is a party, unless such settlement includes an
unconditional release of such Indemnified Party from all liability on claims
that are the subject matter of such Proceeding.

         All fees and expenses of the Indemnified Party (including reasonable
fees and expenses to the extent incurred in connection with investigating or
preparing to defend such Proceeding in a manner not inconsistent with this
Section) shall be paid to the Indemnified Party, as incurred, within ten
Business Days of written notice thereof to the Indemnifying Party (regardless of
whether it is ultimately determined that an Indemnified Party is not entitled to
indemnification hereunder; provided, that the Indemnifying Party may require
such Indemnified Party to undertake to reimburse all such fees and expenses to
the extent it is finally judicially determined that such Indemnified Party is
not entitled to indemnification hereunder).

(t)  Contribution. If a claim for indemnification under Section 5(a) or 5(b) is
unavailable to an Indemnified Party (by reason of public policy or otherwise),
then each Indemnifying Party, in lieu of indemnifying such Indemnified Party,
shall contribute to the amount paid or payable by such Indemnified Party as a
result of such Losses, in such proportion as is appropriate to reflect the
relative fault of the Indemnifying Party and Indemnified Party in connection
with the actions, statements or omissions that resulted in such Losses as well
as any other relevant equitable considerations and relative benefits received.
The relative fault of such Indemnifying Party and Indemnified Party shall be
determined by reference to, among other things, whether any action in question,
including any untrue or alleged untrue statement of a material fact or omission
or alleged omission of a material fact, has been taken or made by, or


<PAGE>

relates to information supplied by, such Indemnifying Party or Indemnified
Party, and the parties' relative intent, knowledge, access to information and
opportunity to correct or prevent such action, statement or omission. The amount
paid or payable by a party as a result of any Losses shall be deemed to include,
subject to the limitations set forth in Section 5(c), any reasonable attorneys'
or other reasonable fees or expenses incurred by such party in connection with
any Proceeding to the extent such party would have been indemnified for such
fees or expenses if the indemnification provided for in this Section was
available to such party in accordance with its terms.

         The parties hereto agree that it would not be just and equitable if
contribution pursuant to this Section 5(d) were determined by pro rata
allocation or by any other method of allocation that does not take into account
the equitable considerations referred to in the immediately preceding paragraph.
Notwithstanding the provisions of this Section 5(d), no Holder shall be required
to contribute, in the aggregate, any amount in excess of the amount by which the
proceeds actually received by such Holder from the sale of the Registrable
Securities subject to the Proceeding exceeds the amount of any damages that such
Holder has otherwise been required to pay by reason of such untrue or alleged
untrue statement or omission or alleged omission. No Person guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the Securities Act)
shall be entitled to contribution from any Person who was not guilty of such
fraudulent misrepresentation.

         The indemnity and contribution agreements contained in this Section are
in addition to any liability that the Indemnifying Parties may have to the
Indemnified Parties.

Miscellaneous

(u)  Remedies. In the event of a breach by the Company or by a Holder, of any of
their obligations under this Agreement, each Holder or the Company, as the case
may be, in addition to being entitled to exercise all rights granted by law and
under this Agreement, including recovery of damages, will be entitled to
specific performance of its rights under this Agreement. The Company and each
Holder agree that monetary damages would not provide adequate compensation for
any losses incurred by reason of a breach by it of any of the provisions of this
Agreement and hereby further agrees that, in the event of any action for
specific performance in respect of such breach, it shall waive the defense that
a remedy at law would be adequate.

(v)  No Inconsistent Agreements. Neither the Company nor any of its subsidiaries
has entered, as of the date hereof, nor shall the Company or any of its
subsidiaries, on or after the date of this Agreement, enter into any agreement
with respect to its securities that is inconsistent with the rights granted to
the Holders in this Agreement or otherwise conflicts with the provisions hereof.
Except as and to the extent specified in Schedule 6(b) hereto, neither the
Company nor any of its subsidiaries has previously entered into any agreement
granting any registration rights with respect to any of its securities to any
Person.

(w) No Piggyback on Registrations. Except as and to the extent specified in
Schedule 6(b) hereto, neither the Company nor any of its security holders (other
than the Holders in such capacity pursuant hereto) may include securities of the
Company in the Registration


<PAGE>

Statement other than the Registrable Securities, and the Company shall not after
the date hereof enter into any agreement providing any such right to any of its
security holders.

(x) Compliance. Each Holder covenants and agrees that it will comply with the
prospectus delivery requirements of the Securities Act as applicable to it in
connection with sales of Registrable Securities pursuant to the Registration
Statement.

(y) Discontinued Disposition. Each Holder agrees by its acquisition of such
Registrable Securities that, upon receipt of a notice from the Company of the
occurrence of any event of the kind described in Sections 3(d)(ii), 3(d)(iii),
3(d)(iv), 3(d)(v) or 3(d)(vi), such Holder will forthwith discontinue
disposition of such Registrable Securities under the Registration Statement
until such Holder's receipt of the copies of the supplemented Prospectus and/or
amended Registration Statement contemplated by Section 3(j), or until it is
advised in writing (the "Advice") by the Company that the use of the applicable
Prospectus may be resumed, and, in either case, has received copies of any
additional or supplemental filings that are incorporated or deemed to be
incorporated by reference in such Prospectus or Registration Statement. The
Company may provide appropriate stop orders to enforce the provisions of this
paragraph.

(z) Piggy-Back Registrations. If at any time during the Effectiveness Period
there is not an effective Registration Statement covering all of the Registrable
Securities and the Company shall determine to prepare and file with the
Commission a registration statement relating to an offering for its own account
or the account of others under the Securities Act of any of its equity
securities, other than on Form S-4 or Form S-8 (each as promulgated under the
Securities Act) or their then equivalents relating to equity securities to be
issued solely in connection with any acquisition of any entity or business or
equity securities issuable in connection with stock option or other employee
benefit plans, then the Company shall send to each Holder written notice of such
determination and, if within fifteen days after receipt of such notice, any such
Holder shall so request in writing, the Company shall include in such
registration statement all or any part of such Registrable Securities such
holder requests to be registered.

(aa) Amendments and Waivers. The provisions of this Agreement, including the
provisions of this sentence, may not be amended, modified or supplemented, and
waivers or consents to departures from the provisions hereof may not be given,
unless the same shall be in writing and signed by the Company and the Holders of
at least two-thirds of the then outstanding Registrable Securities.
Notwithstanding the foregoing, a waiver or consent to depart from the provisions
hereof with respect to a matter that relates exclusively to the rights of
Holders and that does not directly or indirectly affect the rights of other
Holders may be given by Holders of at least a majority of the Registrable
Securities to which such waiver or consent relates; provided, however, that the
provisions of this sentence may not be amended, modified, or supplemented except
in accordance with the provisions of the immediately preceding sentence.

(bb) Notices. Any and all notices or other communications or deliveries required
or permitted to be provided hereunder shall be in writing and shall be deemed
given and effective on the earliest of (i) the date of transmission, if such
notice or communication is delivered via facsimile at the facsimile telephone
number specified in this Section prior to 6:30


<PAGE>

p.m. (New York City time) on a Business Day, (ii) the Business Day after the
date of transmission, if such notice or communication is delivered via facsimile
at the facsimile telephone number specified in the Purchase Agreement later than
6:30 p.m. (New York City time) on any date and earlier than 11:59 p.m. (New York
City time) on such date, (iii) the Business Day following the date of mailing,
if sent by nationally recognized overnight courier service, or (iv) upon actual
receipt by the party to whom such notice is required to be given. The address
for such notices and communications shall be as follows: If to the Company:
SafeScience, Inc. Park Square Building 31 St. James Avenue, 8th Floor Boston, MA
02116 Fax: 617-422-0675 Attn: John Burns Chief Financial Officer

         With copies to:            McDermott Will & Emery
                                    50 Rockefeller Plaza
                                    New York, NY  10020-1605
                                    Facsimile No.:   212-547-5444
                                    Attn: Cheryl Reicin, Esq.

         If                         to a Purchaser: To the
                                    address set forth under
                                    such Purchaser's name on
                                    the signature pages hereto.

         If to any other Person who is then the registered Holder:

                                    To the address of such Holder as it appears
                                    in the stock transfer books of the Company

or such other address as may be designated in writing hereafter, in the same
manner, by such Person.

(cc) Successors and Assigns. This Agreement shall inure to the benefit of and be
binding upon the successors and permitted assigns of each of the parties and
shall inure to the benefit of each Holder. The Company may not assign its rights
or obligations hereunder without the prior written consent of each Holder. Each
Holder may assign their respective rights hereunder in the manner and to the
Persons as permitted under the Purchase Agreement.

(dd) Counterparts. This Agreement may be executed in any number of counterparts,
each of which when so executed shall be deemed to be an original and, all of
which taken together shall constitute one and the same Agreement. In the event
that any signature is delivered by facsimile transmission, such signature shall
create a valid binding obligation of the party executing (or on whose behalf
such signature is executed) the same with the same force and effect as if such
facsimile signature were the original thereof.

(ee) Governing Law. All questions concerning the construction, validity,
enforcement and interpretation of this Agreement shall be governed by and
construed and enforced in accordance with the internal laws of the State of New
York, without regard to the principles of conflicts of law thereof. Each party
hereby irrevocably submits to the exclusive


<PAGE>

jurisdiction of the state and federal courts sitting in the City of New York,
borough of Manhattan, for the adjudication of any dispute hereunder or in
connection herewith or with any transaction contemplated hereby or discussed
herein, and hereby irrevocably waives, and agrees not to assert in any suit,
action or proceeding, any claim that it is not personally subject to the
jurisdiction of any such court, that such suit, action or proceeding is
improper. Each party hereby irrevocably waives personal service of process and
consents to process being served in any such suit, action or proceeding by
mailing a copy thereof to such party at the address in effect for notices to it
under this Agreement and agrees that such service shall constitute good and
sufficient service of process and notice thereof. Nothing contained herein shall
be deemed to limit in any way any right to serve process in any manner permitted
by law.

(ff) Cumulative Remedies. The remedies provided herein are cumulative and not
exclusive of any remedies provided by law.

(gg) Severability. If any term, provision, covenant or restriction of this
Agreement is held by a court of competent jurisdiction to be invalid, illegal,
void or unenforceable, the remainder of the terms, provisions, covenants and
restrictions set forth herein shall remain in full force and effect and shall in
no way be affected, impaired or invalidated, and the parties hereto shall use
their reasonable efforts to find and employ an alternative means to achieve the
same or substantially the same result as that contemplated by such term,
provision, covenant or restriction. It is hereby stipulated and declared to be
the intention of the parties that they would have executed the remaining terms,
provisions, covenants and restrictions without including any of such that may be
hereafter declared invalid, illegal, void or unenforceable.

(hh) Headings. The headings in this Agreement are for convenience of reference
only and shall not limit or otherwise affect the meaning hereof.

(ii) Shares Held by the Company and its Affiliates. Whenever the consent or
approval of Holders of a specified percentage of Registrable Securities is
required hereunder, Registrable Securities held by the Company or its Affiliates
(other than any Holder or transferees or successors or assigns thereof if such
Holder is deemed to be an Affiliate solely by reason of its holdings of such
Registrable Securities) shall not be counted in determining whether such consent
or approval was given by the Holders of such required percentage.

(jj) Independent Nature of Purchasers' Obligations and Rights. The obligations
of each Purchaser hereunder is several and not joint with the obligations of any
other Purchaser hereunder, and neither Purchaser shall be responsible in any way
for the performance of the obligations of any other Purchaser hereunder. Nothing
contained herein or in any other agreement or document delivered at any closing,
and no action taken by any Purchaser pursuant hereto or thereto, shall be deemed
to constitute the Purchasers as a partnership, an association, a joint venture
or any other kind of entity, or create a presumption that the Purchasers are in
any way acting in concert with respect to such obligations or the transactions
contemplated by this Agreement. Each Purchaser shall be entitled to protect and
enforce its rights, including without limitation the rights arising out of this
Agreement, and it shall not be necessary for any other Purchaser to be joined as
an additional party in any proceeding for such purpose.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK
                           SIGNATURE PAGES TO FOLLOW]


<PAGE>


         IN WITNESS WHEREOF, the parties have executed this Registration Rights
Agreement as of the date first written above.

                                           SAFESCIENCE, INC.



                                           By:__________________________________
                                                Name:
                                                Title:



                   [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK
                     SIGNATURE PAGES OF PURCHASER TO FOLLOW]


<PAGE>


                         STRONG RIVER INVESTMENTS, INC.


                                       By:_____________________________________
                                            Name:  Miriam O. Hyman
                                            Title:   Attorney-in-Fact

                                       Address for Notice:

                         Strong River Investments, Inc.
                                        c/o Gonzalez-Ruiz & Aleman (BVI) Limited
                                        Wickhams Cay I, Vanterpool Plaza
                                        P.O. Box 873
                            Road Town, Tortolla, BVI


                                            With copies to:

                                         Robinson Silverman Pearce Aronsohn
                                         & Berman LLP
                                         1290 Avenue of the Americas
                                         New York, NY 10104
                                         Facsimile No.:  (212) 541-4630 and
                                         (212) 541-1432
                                         Attn: Kenneth L. Henderson, Esq. and
                                         Eric L. Cohen, Esq.



<PAGE>


                            MONTROSE INVESTMENTS LTD.



                                            By:_________________________________
                                                 Name:
                                                 Title:

                                            Address for Notice:

                                            Montrose Investments Ltd.
                                            300 Crescent Court, Suite 700
                                            Dallas, TX 75201
                                            Facsimile: (214) 758-1221
                                            Attn:    Will Rose
                                                     Kim Rozman

                                            With copies to:

                                            Robinson Silverman Pearce Aronsohn
                                            & Berman LLP
                                            1290 Avenue of the Americas
                                            New York, NY 10104
                                            Facsimile No.:  (212) 541-4630 and
                                            (212) 541-1432
                                            Attn:    Kenneth L. Henderson, Esq.
                                                     Eric L. Cohen, Esq.



<PAGE>


                                                                         Annex A
                                                                         -------

                              PLAN OF DISTRIBUTION
                              --------------------


         The Selling Stockholders and any of their pledgees, assignees and
successors-in-interest may, from time to time, sell any or all of their shares
of Common Stock on any stock exchange, market or trading facility on which the
shares are traded or in private transactions. These sales may be at fixed or
negotiated prices. The Selling Stockholders may use any one or more of the
following methods when selling shares:

$        ordinary brokerage transactions and transactions in which the broker-
         dealer solicits purchasers;

$        block trades in which the broker-dealer will attempt to sell the shares
         as agent but may position and resell a portion of the block as
         principal to facilitate the transaction;

$        purchases by a broker-dealer as principal and resale by the broker-
         dealer for its account;

$        an exchange distribution in accordance with the rules of the applicable
         exchange;

$        privately negotiated transactions;

$        broker-dealers may agree with the Selling Stockholders to sell a
         specified number of such shares at a stipulated price per share;

$        a combination of any such methods of sale; and

$        any other method permitted pursuant to applicable law.

         The Selling Stockholders may also sell shares under Rule 144 under the
Securities Act, if available, rather than under this prospectus.

         Broker-dealers engaged by the Selling Stockholders may arrange for
other brokers-dealers to participate in sales. Broker-dealers may receive
commissions or discounts from the Selling Stockholders (or, if any broker-dealer
acts as agent for the purchaser of shares, from the purchaser) in amounts to be
negotiated. The Selling Stockholders do not expect these commissions and
discounts to exceed what is customary in the types of transactions involved.

         The Selling Stockholders and any broker-dealers or agents that are
involved in selling the shares may be deemed to be "underwriters" within the
meaning of the Securities Act in connection with such sales. In such event, any
commissions received by such broker-dealers or agents and any profit on the
resale of the shares purchased by them may be deemed to be underwriting
commissions or discounts under the Securities Act.

         The Company is required to pay all fees and expenses incident to the
registration of the shares, including up to $7,500 of the fees and disbursements
of counsel to the Selling Stockholders. The Company has agreed to indemnify the
Selling Stockholders against certain losses, claims, damages and liabilities,
including liabilities under the Securities Act.




                         STRONG RIVER INVESTMENTS, INC.
                    C/O GONZALEZ-RUIZ & ALEMAN (BVI) LIMITED
                        WICKHAMS CAY I, VANTERPOOL PLAZA
                                  P.O. BOX 873
                           ROAD TOWN, TORTOLLA. B.V.I.

                            MONTROSE INVESTMENTS LTD.
                          300 CRESCENT COURT, SUITE 700
                                DALLAS, TX 75201



                                                                  March 29, 2000

SafeScience, Inc.
Park Square Building
31 St. James Avenue, 8th Floor
Boston, MA 02116
Attention: President

         Re:      SafeScience, Inc. (the "Company").
                  ----------------------------------

Gentlemen:

                  Reference is made to the Securities Purchase Agreement (the
"Purchase Agreement"), of even date hereof, between the Company and the
undersigned (the "Purchasers"), pursuant to which the Company will issue and
sell to the Purchasers (i) up to 484,429 shares of Common Stock (the "Initial
Shares"), (ii) Common Stock purchase warrants, each in the form of Exhibit A to
the Purchase Agreement, pursuant to which the holder thereof shall have the
right, under certain circumstances described therein, to acquire shares of
Common Stock upon the terms set forth therein (the "Initial Adjustable Warrant")
and (iii) Common Stock purchase warrants, each in the form of Exhibit B to the
Purchase Agreement, pursuant to which the holder thereof shall have the right,
under certain circumstances described therein, to acquire shares of Common Stock
upon the terms set forth therein (the "Initial Closing Warrants" and together
with the Initial Adjustable Warrants, the "Initial Warrants"), for an aggregate
purchase price of up to $7,000,000. Capitalized terms used and not otherwise
defined in this letter that are defined in the Purchase Agreement shall have the
meanings set forth in the Purchase Agreement. The Initial Warrants and the
Initial Shares are sometimes collectively referred to herein as the "Initial
Securities."

                  The Purchasers shall, severally and not jointly, commit,
subject to and upon the terms and conditions hereof, to purchase from the
Company, and the Company shall sell to the Purchasers on the Additional Closing
Date (as defined herein): (i) up to [ ] 1


- --------
1 The number which equals $7,000,000 divided by the lesser of (i) 110% of the
average of the Per Share Market Values for the four Trading Days preceding the
Additional Closing Date and (ii) $16.00 (subject to equitable adjustment for
stock splits, recombinations and similar events).

<PAGE>

shares of Common Stock (the "Additional Shares"), (ii) additional Initial
Adjustable Warrants (the "Additional Adjustable Warrants") and (iii) additional
Initial Closing Warrants pursuant to which the holders thereof shall have the
right at any time and from time to time thereafter through the fifth anniversary
of the Additional Closing Date (as defined herein) to acquire an aggregate of up
to [ ] 2 shares of Common Stock (the "Additional Closing Warrants and together
with the Additional Adjustable Warrants, the "Additional Warrants"), for an
aggregate purchase price of $7,000,000 (the "Additional Purchase Price"),
provided, that if the Additional Purchase Price shall exceed 6% of the market
capitalization of the Common Stock on the Additional Closing Date, the
Additional Closing (as defined herein) shall not take place. The Additional
Shares and Additional Warrants are collectively referred to herein as the
"Additional Securities."

                  The commitment of the Purchasers set forth in this letter is
subject to the terms, conditions and qualifications set forth below:

Form of Additional Adjustable Warrants. The Additional Adjustable Warrants shall
be identical to the Initial Adjustable Warrants except that the Purchase Price
applicable thereto shall equal the lesser of (i)110% of the average of the Per
Share Market Values for the four Trading Days preceding the Additional Closing
Date and (ii) $16.00 (subject to equitable adjustment for stock splits,
recombinations and similar events).

2. Form of Additional Closing Warrants. The Additional Closing Warrants shall be
identical to the Initial Closing Warrants except that the Exercise Price (as
defined in the Initial Closing Warrants) shall be equal to 120% of the average
of the closing bid prices of the Common Stock for the five (5) Trading Days
immediately preceding the Additional Closing Date.

3. Additional Documentation. In order to effectuate a purchase and sale of the
Additional Securities, prior to their issuance, the Company and the Purchasers
shall enter into the following agreements: (a) a securities purchase agreement
identical to the Purchase Agreement, mutatis mutandis (the "Additional Purchase
Agreement") and (b) a registration rights agreement identical to the
Registration Rights Agreement, mutatis mutandis (the "Additional Registration
Rights Agreement", and together with the Additional Purchase Agreement, the
Additional Warrants, collectively the "Additional Transaction Documents"). The
Purchasers shall prepare the Additional Transaction Documents.

4. Additional Closing. (i) Each Purchaser and the Company shall each have the
right to deliver a written notice to the other (the "Additional Financing
Notice") requiring such other party to either sell or buy (severally and not
jointly), as the case may be, the Additional Securities for the Additional
Purchase Price. The Additional Financing Notice may be delivered no earlier than
190 days following the Closing Date and no later than 210 days following the
Closing Date, or as otherwise agreed to by the parties hereto. At the Additional
Closing each Purchaser which receives or delivers an Additional Closing



- ------
2 The number which equals 7.5% of $7,000,000 divided by the lesser of (i) 110%
of the average of the Per Share Market Values for the four Trading Days
preceding the Additional Closing Date and (ii) $16.00 (subject to equitable
adjustment for stock splits, recombinations and similar events).


<PAGE>

Notice pursuant to the terms hereof shall (subject to the terms and conditions
herein) purchase such portion of the Additional Securities as equals such
Purchaser's pro-rata portion of the Initial Securities issued and sold at the
Closing. The closing of the purchase and sale of Additional Securities (the
"Additional Closing") shall take place at the offices of Robinson Silverman,1290
Avenue of the Americas, New York, New York 10104, on the fifth (5th) Business
Day after the Additional Financing Notice is received by a Purchaser or the
Company, as the case may be, or on such other date as otherwise agreed to by the
parties hereto, provided, that in no case shall the Additional Closing take
place unless and until all of the conditions listed in Section 5 of this letter
shall have been satisfied by the Company or waived by the Purchasers. The date
of the Additional Closing is hereinafter referred to as the "Additional Closing
Date." Notwithstanding anything to the contrary contained in this letter, each
Purchaser may, prior to the Additional Closing Date, designate an Affiliate
thereof to acquire all or any portion of the Additional Securities.

         (i) At the Additional Closing, the parties shall deliver or shall cause
to be delivered the following: (a) the Company shall deliver to (x) each
Purchaser which receives or delivers an Additional Closing Notice pursuant to
the terms hereof or its designated Affiliate: (1) the number of Additional
Shares purchased equal to such Purchaser's pro rata portion of the Initial
Shares issued and sold at the Closing, registered in the name of such Purchaser
or its designated Affiliate, (2) an Additional Adjustable Warrant registered in
the name of such Purchaser or its designated Affiliate, (3) an Additional
Closing Warrant registered in the name of such Purchaser or its designated
Affiliate, entitling the holder thereof to purchase such number of shares of
Common Stock as equals such Purchaser's pro-rata portion of the shares of Common
Stock underlying the Initial Closing Warrant issued and sold at the Closing to
such Purchaser, (4) a legal opinion in form and substance acceptable to the
Purchasers, (5) an officer's certificate pursuant to Section 5(b) hereof and (6)
executed Additional Transaction Documents and the Transfer Agent Instructions
relating to the Additional Securities, and (y) Robinson Silverman, $20,000 for
the legal fees and expenses incurred by the Purchasers to prepare the Additional
Transaction Documents, which amount shall be deducted by the Purchasers from the
Additional Purchase Price and shall be paid directly to Robinson Silverman and
(b) each Purchaser which receives or delivers an Additional Closing Notice
pursuant to the terms hereof shall deliver to the Company (1) its pro rata
portion of the Additional Purchase Price, in United States dollars in
immediately available funds by wire transfer to an account designated in writing
by the Company for such purpose prior to the Additional Closing Date and (2) the
executed Additional Transaction Documents.

5. Conditions precedent to the Additional Closing. Notwithstanding anything to
the contrary contained in this letter, the commitment of a Purchaser to purchase
the Additional Securities is subject to the satisfaction or waiver by such
Purchaser of each of the following conditions:

     (a) Closing of Initial Shares and Initial Warrants. The Closing shall have
occurred;

     (b) Accuracy of the Company's Representations and Warranties. The

<PAGE>

representations and warranties of the Company contained in the Purchase
Agreement shall be true and correct as of the date when made and as of the
Additional Closing Date as though made on and as of the Additional Closing Date
(other than representations and warranties which relate to a specific date
(which shall not include representations and warranties relating to the "date
hereof") which representations and warranties shall be true as of such specific
date), as evidenced by an officer's certificate attesting to such effect to be
delivered by the Company to the Purchasers at the Additional Closing Date;

     (c) Performance by the Company. The Company shall have performed, satisfied
and complied with all covenants, agreements and conditions required by the
Transaction Documents to be performed, satisfied or complied with by the Company
between the Closing Date and the Additional Closing Date and no Event (as
defined in the Registration Rights Agreement ) shall have occurred which has not
been cured to the satisfaction of the Purchasers;

     (d) Underlying Shares Registration Statement. The Underlying Shares
Registration Statement shall have been declared effective under the Securities
Act by the Commission and shall have remained effective at all times, not
subject to any actual or threatened stop order or subject to any actual or
threatened suspension at any time prior to the Additional Closing Date;

     (e) No Injunction. Since the Closing Date, no statute, rule, regulation,
executive order, decree, ruling or injunction shall have been enacted, entered,
promulgated, amended, modified or endorsed by any court of governmental
authority of competent jurisdiction or governmental authority, stock market or
trading facility which prohibits the consummation of any of the transactions
contemplated by the Additional Transaction Documents or makes impracticable the
transactions contemplated thereby;

     (f) Adverse Changes. Since the Closing Date, no event or series of events
which reasonably would be expected to have or result in a Material Adverse
Effect shall have occurred;

     (g) No Suspensions of Trading in Common Stock. The trading in the Common
Stock shall not have been suspended by the Commission or on the NASDAQ at any
time since the Closing Date and the Company shall not have received any notice
of threatened or pending proceedings for delisting the Common Stock from NASDAQ;


     (h) Listing of Common Stock. The Common Stock shall have been at all times
since the Closing Date listed for trading on the NASDAQ;

     (i) Shares of Common Stock. The Company shall have duly reserved the number
of shares of Common Stock as required by the Additional Transaction Documents to
be reserved for issuance upon exercise of the Additional Warrants;

     (j) Performance of Exercise Obligations. The Company shall have timely
complied with its exercise and delivery requirements under the Initial Warrants;

     (k) Closing Threshold. For the ten (10) Trading Days immediately preceding

<PAGE>

the date of the delivery of the Additional Financing Notice, the average daily
trading volume of the Common Stock on the NASDAQ shall be at least 50,000 shares
and the average of the Per Share Market Value for such ten (10) Trading Day
period shall be greater than $10.00 (subject to equitable adjustments for stock
splits, recombinations and similar events);

     (l) Shareholder Approval. No approval of the shareholders of the Company
shall be required under the rules of the Nasdaq Stock Market or such other
exchange or trading facility or which the Common Stock is the traded or listed
for trading in order to issue a minimum of twice the number of the shares of
Common Stock issuable upon exercise of the Additional Adjustable Warrants
(assuming(x) such exercise occurred on the Additional Closing Date (y) the
Applicable Share Number (as defined in the Additional Adjustable Warrants)
relating to each Additional Adjustable Warrant equals 100% of the Additional
Shares and (z) and Adjustment Price (as defined in the Additional Adjustable
Warrants) shall be deemed to mean the average of the four lowest Per Share
Market Values (which need not occur on consecutive Trading Days) during the 40
consecutive Trading Days preceding the Additional Closing Date); and

     (m) Deliveries pursuant to the Additional Transaction Documents. At the
Additional Closing, the Company shall deliver the Additional Securities and
executed Additional Transaction Documents and Transfer Agent Instructions
relating to the Additional Securities in the forms contemplated by this letter.

6.  Independent Nature of Purchasers' Obligations and Rights. The obligations of
each Purchaser hereunder is several and not joint with the obligations of any
other Purchaser hereunder, and neither Purchaser shall be responsible in any way
for the performance of the obligations of any other Purchaser hereunder. Nothing
contained herein or in any other agreement or document delivered at any closing,
and no action taken by any Purchaser pursuant hereto or thereto, shall be deemed
to constitute the Purchasers as a partnership, an association, a joint venture
or any other kind of entity, or create a presumption that the Purchasers are in
any way acting in concert with respect to such obligations or the transactions
contemplated by this Agreement. Each Purchaser shall be entitled to protect and
enforce its rights, including, without limitation, the rights arising out of
this letter or out of the Additional Transaction Documents, if any, and it shall
not be necessary for any other Purchaser to be joined as an additional party in
any proceeding for such purpose.

7. Governing Law. This letter shall be governed by and construed and enforced in
accordance with the internal laws of the State of New York, without regard to
the principles of conflicts of law thereof.

8. Execution. This letter may be executed in two or more counterparts, all of
which when taken together shall be considered one and the same agreement and
shall become effective when counterparts have been signed by each party and
delivered to the other party, it being understood that both parties need not
sign the same counterpart. In the event that any signature is delivered by
facsimile transmission, such signature shall create a valid and binding
obligation of the party executing (or on whose behalf such signature is
executed) the same with the same force and effect as if such facsimile signature
page were an original thereof.



<PAGE>


                  Please indicate your agreement with the foregoing by executing
a countersigned copy of this letter and returning the same to our attention,
whereupon effective immediately thereafter this letter shall become a legally
valid and binding agreement between the Purchasers and the Company.

                  We look forward to our continuing relationship.

                  Sincerely,

                  Strong River Investments, Inc.



                  By:    _______________________
                         Name: Miriam O. Hyman
                         Title: Attorney-in-Fact

                  Montrose Investments Ltd.



                  By:    _______________________
                         Name:
                         Title:


Agreed and accepted
March 29, 2000

SafeScience, Inc.


By:    _______________________
       Name:
       Title:











CONTACTS:
Rick Pierce                                                   Douglas Macdougal
V.P. Finance & Investor Relations                    Chris Erdman
SafeScience, Inc.                                    Feinstein Kean Healthcare
617-422-0674                                         (617) 577-8110
www.safescience.com

COMPANY PRESS RELEASE
SAFESCIENCE, INC. COMPLETES RAISE OF $9 MILLION IN PRIVATE OFFERINGS WITH A
TOTAL POTENTIAL OF $18 MILLION INSTITUTIONAL INVESTORS TAKE STAKE IN BOSTON
BASED SAFESCIENCE, INC. Boston, MA (Pr News Wire)--March 31, 2000 --
SafeScience, Inc., a biotechnology and consumer products company (NASDAQ: SAFS),
announced today that it has closed two private placements of its securities for
a total of $9,000,000. A group of investors led by Cavallo Capital Corp
purchased $5,000,000 of the Company's securities in a private offering with a
commitment to purchase an additional $9,000,000 of the Company's securities
subject to certain conditions. In addition to the initial $5,000,000 investment
led by Cavallo Capital Corp, the Company also raised $4,000,000 dollars
privately with an institution and three accredited investors. Investment bank
Gerard, Klauer, Mattison & Co Inc. acted as placement agent and George K. Baum &
Company served as an advisor on the transaction. The Company plans to use the
proceeds of this offering for financing its growing consumer products business,
Phase II clinical trials of its lead pharmaceutical compound GBC-590, as well
as, general working capital purposes.

Bradley J. Carver, President of SafeScience, stated "This financing will help us
to accelerate a number of specific goals that we have set out to accomplish this
year. "

SAFESCIENCE
SafeScience is developing and in-licensing a portfolio of efficacious
pharmaceutical, agricultural, and consumer products to be marketed under the
SafeScience(R) world brand, as an alternative to conventional products employing
potentially harmful chemicals. The Company's human therapeutic products include
GBC-590, a unique compound to treat cancer, which is in human clinical trials,
as well as a promising new antifungal compound, CAN-296, for the treatment of
human fungal infections, currently in pre-clinical testing. In the area of
agriculture, SafeScience is introducing Elexa(R) Plant Defense Booster, an
innovative approach, which stimulates the plant to protect itself against
pathogens. SafeScience's line of consumer and industrial products include
environmentally and human-safe cleaners, which are being marketed through both
retail and commercial channels. Further information is available on
SafeScience's web site: HTTP://WWW.SAFESCIENCE.COM.


I.       SAFE HARBOR STATEMENT
Any statements contained in this release that relate to future plans, events or
performance are forward-looking statements that involve risks and uncertainties,
including, but not limited to, risks of product nonapproval or product
development and market acceptance risks, the impact of competitive products and
pricing, the results of current and future licensing and other collaborative
relationships, the results of financing efforts, developments regarding
intellectual property rights and litigation, and other risks identified in the
Company's Securities and Exchange Commission filings. Actual results, events or
performance may differ materially. Readers are cautioned not to place undue
reliance on these forward-looking statements, which speak only as the date
hereof. The Company undertakes no obligation to publicly release the results of
any revisions to these forward-looking statements that may be made to reflect
events or circumstances after the date hereof or to reflect the occurrence of
unanticipated events.






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