VIROPHARMA INC
SC 13G, 1998-02-13
PHARMACEUTICAL PREPARATIONS
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                         SECURITIES AND EXCHANGE COMMISSION
                                Washington, DC 20549

                                    Schedule 13G
                                   (Rule 13d-102)

              INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT 
                TO RULES 13d-1(b)and(c)AND AMENDMENTS THERETO FILED 
                                PURSUANT TO 13d-2(b)
                             (Amendment No. ________)(1)

                                  ViroPharma, Inc.
                                  (Name of Issuer)

                      Common Stock, $.002 par value per share
                           (Title of Class of Securities)

                                    928241 10 8
                                   (CUSIP Number)














(1)  The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 or otherwise subject to the liabilities of that section of the Act but
shall be subject to all other provisions of the Act (however, see the Notes).


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CUSIP NO. 928241 10 8              13G

1.   NAMES OF REPORTING PERSONS 
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Technology Leaders II L.P. 23-2787137

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  / x /
                                                       (b)  /   /
3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION
     
     Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
     
     5.   SOLE VOTING POWER

     6.   SHARED VOTING POWER                1,266,700
     
     7.   SOLE DISPOSITIVE POWER

     8.   SHARED DISPOSITIVE POWER           1,266,700

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,266,700

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* /  /

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     11.1%

12.  TYPE OF REPORTING PERSON*

     PN 


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CUSIP NO. 928241 10 8              13G

1.   NAMES OF REPORTING PERSONS 
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Technology Leaders II Offshore C.V.

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  / x /
                                                       (b)  /   /
3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Netherlands Antilles

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

     5.   SOLE VOTING POWER

     6.   SHARED VOTING POWER                1,266,700
     
     7.   SOLE DISPOSITIVE POWER

     8.   SHARED DISPOSITIVE POWER           1,266,700

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,266,700

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* /  /

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     11.1%

12.  TYPE OF REPORTING PERSON*

     PN 


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CUSIP NO. 928241 10 8              13G

1.   NAMES OF REPORTING PERSONS 
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Technology Leaders II Management L.P. 23-2787138

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                      (a)  / x /
                                                      (b)  /   /
3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
     
     5.   SOLE VOTING POWER

     6.   SHARED VOTING POWER                1,266,700
     
     7.   SOLE DISPOSITIVE POWER

     8.   SHARED DISPOSITIVE POWER           1,266,700

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,266,700

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* /  /

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     11.1%     

12.  TYPE OF REPORTING PERSON*

     PN


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Item 1 (a)     Name of Issuer:
               -------------- 
ViroPharma, Inc.

Item 1 (b)     Address of Issuer's Principal Executive Offices:
               -----------------------------------------------
75 Great Valley Parkway
Malvern, PA  19355

Item 2 (a)     Name of Person Filing:
               ---------------------
(1)  Technology Leaders II L.P.
(2)  Technology Leaders II Offshore C.V.
(3)  Technology Leaders II Management L.P.

Item 2 (b)     Address of Principal Business Office:
               ------------------------------------
(1)(3)         800 The Safeguard Building 
               435 Devon Park Drive
               Wayne, PA 19087-1945

(2)            c/o ABN Trustcompany (Curacao) N.V.
               P. O. Box 224
               15 Pietermaai
               Curacao, Netherland Antilles

Item 2 (c)     Citizenship:
               -----------
(1)  Delaware limited partnership
(2)  Netherland Antilles limited partnership
(3)  Delaware limited partnership
 

Item 2 (d)     Title of Class of Securities:
               ---------------------------- 
Common Stock, $.002 par value per share

Item 2 (e)     CUSIP Number:
               ------------
928241 10 8

Item 3    If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b),
          -------------------------------------------------------------------
          check whether the person filing is a :
          --------------------------------------
          (a)  /  / Broker or dealer registered under Section 15 of 
                    the Act.

          (b)  /  / Bank as defined in Section 3(a)(6) of the Act.

          (c)  /  / Insurance Company as defined in Section 3(a)(19) 
                    of the Act.

          (d)  /  / Investment Company registered under Section 8 of 
                    the Investment Company Act of 1940.

          (e)  /  / Investment Adviser registered under Section 203 
                    of the Investment Advisers Act of 1940.


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          (f)  /  / Employee Benefit Plan, Pension Fund which is 
                    subject to the provisions of the Employee 
                    Retirement Income Security Act of 1974 or 
                    Endowment Fund; see 13d-1(b)(1)(ii)(F).

          (g)  /  / Parent Holding Company, in accordance with Rule 
                    13d-1(b)(ii)(G); see Item 7.

          (h)  /  / Group, in accordance with Rule 13d-
                    1(b)(1)(ii)(H).

Not applicable

Item 4    Ownership:
          ----------
(a)  Amount Beneficially Owned:

     (1)(2)(3) 1,266,700 shares

(b)  Percent of Class:

     (1)(2)(3) 11.1%

(c)  Number of shares as to which such person has:

     (i)    sole power to vote or to direct the vote:

            0

     (ii)   shared power to vote or to direct the vote:

            (1)(2)(3) 1,266,700

     (iii)  sole power to dispose or to direct the disposition of:

            0

     (iv)   shared power to dispose or to direct the disposition of:

            (1)(2)(3) 1,266,700


Technology Leaders II Management L.P. is the sole general partner of Technology
Leaders II L.P. ("TL II") and a co-general partner of Technology Leaders II
Offshore C.V. ("TLO II").  TL II and TLO II are venture capital funds which are
required by their governing documents to make all investment, voting and
disposition actions in tandem.  TL II is the record holder of 705,931 shares and
TLO II is the record holder of 560,769 shares.  Technology Leaders Management II
L.P. has sole authority and responsibility for all investment, voting and
disposition decisions for Technology Leaders II, which powers are exercised
through its ten person executive committee, by whose decisions the general
partners have agreed to be bound.  

Item 5    Ownership of Five Percent or Less of a Class:
          ---------------------------------------------
Not Applicable

Item 6    Ownership of More than Five Percent on Behalf of Another Person:
          ----------------------------------------------------------------
Not applicable


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Item 7    Identification and Classification of the Subsidiary Which Acquired the
          ----------------------------------------------------------------------
          Security Being Reported on By the Parent Holding Company:
          ---------------------------------------------------------
Not applicable

Item 8    Identification and Classification of Members of the Group:
          ----------------------------------------------------------
Technology Leaders II L.P., Technology Leaders II Offshore C.V. and Technology
Leaders II Management L.P. are members of a group for purposes of Sections 13(d)
and 13(g) of the Securities Exchange Act of 1934.

Item 9    Notice of Dissolution of Group:
          -------------------------------               
Not applicable

Item 10   Certification:
          --------------
By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were acquired in the ordinary course of business
and were not acquired for the purpose of and do not have the effect of changing
or influencing the control of the issuer of such securities and were not
acquired in connection with or as a participant in any transaction having such
purpose or effect.
          
          
                                     SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct. 
In executing this statement, the undersigned agrees, to the extent required by
Rule 13d-1(f), that this statement is being filed on behalf on each of the
Reporting Persons herein.
                              TECHNOLOGY LEADERS II L.P.
                              By Technology Leaders II Management L.P., general
                              partner

                              By:  /s/ Robert E. Keith, Jr.
                                   -----------------------------------------
                                   Robert E. Keith Jr.
                                   President, Technology Leaders Management,
                                   Inc., a general partner
Dated:  February 9, 1998

                              TECHNOLOGY LEADERS II OFFSHORE C.V.
                              By Technology Leaders II Management L.P., 
                              co-general partner

                              By:  /s/ Robert E. Keith, Jr. 
                                   -----------------------------------------
                                   Robert E. Keith Jr.
                                   President, Technology Leaders Management,
                                   Inc., a general partner
Dated:  February 9, 1998

                              TECHNOLOGY LEADERS II MANAGEMENT L.P.

                              By:  /s/ Robert E. Keith, Jr. 
                                   -----------------------------------------
                                   Robert E. Keith Jr.
                                   President, Technology Leaders 
                                   Management, Inc., a general partner
Dated:  February 9, 1998






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