VIROPHARMA INC
S-8, 1998-08-07
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
    As filed with the Securities and Exchange Commission on August 7, 1998
                                                    Registration No. 333-_______
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
- --------------------------------------------------------------------------------

                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933
- --------------------------------------------------------------------------------

                            VIROPHARMA INCORPORATED
             (Exact name of registrant as specified in its charter)

               DELAWARE                                     23-2789550
     (State or other jurisdiction of                    (I.R.S. employer
     incorporation or organization)                     Identification No.)
 
                            VIROPHARMA INCORPORATED
                            405 EAGLEVIEW BOULEVARD
                           EXTON, PENNSYLVANIA  19341
                    (Address of Principal Executive Offices)
                        _______________________________

                   VIROPHARMA INCORPORATED STOCK OPTION PLAN
                            (Full title of the Plan)
                        _______________________________

                                CLAUDE H. NASH 
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                            VIROPHARMA INCORPORATED
                            405 EAGLEVIEW BOULEVARD
                           EXTON, PENNSYLVANIA  19341
                    (Name and Address of Agent for Service)

                                 (610) 458-7300
          (Telephone number, including area code of agent for service)

                          Copies of Communications to:

      JEFFREY P. LIBSON, ESQUIRE               THOMAS F. DOYLE, ESQUIRE
      PEPPER HAMILTON LLP                      VIROPHARMA INCORPORATED
      1235 WESTLAKES DRIVE, SUITE 400          405 EAGLEVIEW BOULEVARD
      BERWYN, PENNSYLVANIA 19312-2401          EXTON, PENNSYLVANIA 19341

                        CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
 
                                              Proposed Maximum           Proposed Maximum                Amount of
 Title of Securities to      Amount to Be    Offering Price Per     Aggregate Offering Price/(2)/   Registration Fee /(2)/
      Be Registered        Registered /(1)/     Share /(2)/
<S>                        <C>               <C>                  <C>                             <C>
COMMON STOCK, PAR
 VALUE $0.002 PER SHARE             800,000      $ 20.75                 $16,600,000                   $ 4,897.00
=========================================================================================================================
</TABLE>



/(1)/ Pursuant to Rule 416(c) under the Securities Act of 1933, this
Registration Statement also covers such additional shares as may hereinafter be
offered or issued to prevent dilution resulting from stock splits, stock
dividends, recapitalization or certain other capital adjustments.

/(2)/ Calculated pursuant to Rule 457(h) under the Securities Act of 1933, based
upon the average of the high and low sale prices of the Registrant's Common
Stock reported on the NASDAQ National Market on July 31, 1998.
<PAGE>
 
     This Registration Statement is filed solely to reflect an increase of
800,000 shares of the Registrant's common stock, par value $0.002 per share,
reserved for the Registrant's 1995 Stock Option Plan, as amended and restated.
Except as noted below, in accordance with General Instruction E to Form S-8, the
contents of the Registration Statement No. 333-34129 filed on August 22, 1997
are incorporated herein by reference.

                                    PART II
               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 8. Exhibits.
- ---------------- 

     The exhibit list is amended to read in its entirety as follows:

Exhibit Number  Description
- --------------  -----------

5               Opinion of Pepper Hamilton LLP

23.1            Consent of KPMG Peat Marwick LLP

23.2            Consent of Pepper Hamilton LLP (included in its opinion filed as
                Exhibit 5 hereto)

24              Power of Attorney (included on the Signature Page of
                this Registration Statement)

99              ViroPharma Incorporated Stock Option Plan, as amended and
                restated (1)

______________________
(1)  Filed as Annex A to the Registrant's proxy statement filed on April 15,
     1998 (File No. 0-21699)
<PAGE>
 
                        SIGNATURES AND POWER OF ATTORNEY

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized in Exton, Pennsylvania on July 31, 1998.


                              VIROPHARMA INCORPORATED


                              By:  /s/ Claude H. Nash
                                  ----------------------------------------
                                      Claude H. Nash, President and
                                      Chief Executive Officer

     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

     Each person in so signing also makes, constitutes and appoints Claude H.
Nash and Vincent J. Milano, and each of them acting alone, his or her true and
lawful attorney-in-fact and agent with full power of substitution, to execute
and cause to be filed with the Securities and Exchange Commission, pursuant to
the requirements of the Securities Act of 1933, as amended, any and all
amendments and post-effective amendments to this Registration Statement, with
exhibits thereto and other documents in connection therewith, and hereby
ratifies and confirms all that said attorneys-in-fact or his or her substitute
or substitutes, may do or cause to be done by virtue hereof.

<TABLE>
<CAPTION>
 
Name                                                                Title                   Date
- -----------------------------------------------------  -------------------------------  -------------
<S>                                                    <C>                              <C>
 
/s/ Claude H. Nash                                     President, Chief Executive       July 31, 1998
- -----------------------------------------------------  Officer and Chairman of the
Claude H. Nash                                         Board (Principal Executive 
                                                       Officer)                   
                                                                                  
 
/s/ Vincent J. Milano                                  Vice President, Chief            July 31, 1998
- -----------------------------------------------------  Financial Officer and Treasurer
Vincent J. Milano                                                                     


/s/ Frank Baldino, Jr., Ph.D.                          Director                         July 31, 1998
- --------------------------------                                          
Frank Baldino, Jr., Ph.D.


/s/ Robert J. Glaser                                   Director                         July 31, 1998
- -------------------------------------                                                                
Robert J. Glaser                                                                        
                                                                                        
                                                                                        
/s/ Ann H. Lamont                                      Director                         July 31, 1998
- -----------------------------------                                                                  
Ann H. Lamont                                                                           
                                                                                        
                                                                                        
/s/ David J. Williams                                  Director                         July 31, 1998
- -----------------------------------                                             
David J. Williams

</TABLE> 
<PAGE>
 
                                 EXHIBIT INDEX

Exhibit Numbers     Description
- ---------------     -----------

5                   Opinion of Pepper Hamilton LLP

23.1                Consent of KPMG Peat Marwick LLP

23.2                Consent of Pepper Hamilton LLP (included in its opinion
                    filed as Exhibit 5)

24                  Power of Attorney (included on signature page of this
                    Registration Statement)

<PAGE>
 
                                   EXHIBIT 5

                      [LETTERHEAD OF PEPPER HAMILTON LLP]

August 7, 1998

ViroPharma Incorporated
405 Eagleview Boulevard
Exton, Pennsylvania 19341

          Re:  Registration Statement on Form S-8 relating to the ViroPharma
               Incorporated Stock Option Plan, as amended and restated
               -------------------------------------------------------------

Ladies and Gentlemen:

          We have acted as counsel to ViroPharma Incorporated, a Delaware
corporation (the "Company") in connection with the Registration Statement on
Form S-8 (the "Registration Statement") filed by the Company with the Securities
and Exchange Commission pursuant to the Securities Act of 1933, as amended (the
"Act"), relating to an additional 800,000 shares of the Company's common stock,
par value $0.002 per share (the "Common Stock"), reserved for and issuable under
the ViroPharma Incorporated Stock Option Plan, as amended and restated (the
"Plan").

          In rendering this opinion, we have examined the Registration Statement
and the exhibits thereto, including the Plan, certain records of the Company's
corporate proceedings as reflected in its minute books and such statutes,
records and other documents as we have deemed relevant.  In our examination, we
have assumed the genuineness of documents submitted to us as originals and the
conformity with the originals of all documents submitted to us as copies
thereof.

          Based on the foregoing, it is our opinion that the shares of Common
Stock issuable under the Plan will be, when issued and paid for in accordance 
with the terms of the Plan, validly issued, fully paid and non-assessable.

          The opinion set forth above is limited to the General Corporation Law
of the State of Delaware, as amended.

          We hereby consent to the use of this opinion as Exhibit 5 to the
Registration Statement.  In giving such consent, we do not thereby admit that we
are acting within the category of persons whose consent is required under
Section 7 of the Act and the rules or regulations of the Commission thereunder.

          The opinion expressed herein is solely for your benefit and may be
relied upon only by you.


                              Sincerely,


                              PEPPER HAMILTON LLP

<PAGE>
 
                                 EXHIBIT 23.1




The Stockholders and Board of Directors
ViroPharma Incorporated:

We consent to the use of our report incorporated herein by reference.

                                                           KPMG Peat Marwick LLP




Princeton, New Jersey
August 5, 1998


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