VIROPHARMA INC
SC 13G/A, 1998-02-12
PHARMACEUTICAL PREPARATIONS
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<PAGE>


                                    UNITED STATES
                          SECURITIES AND EXCHANGE COMMISSION
                                Washington, DC  20549

                                     SCHEDULE 13G

                      Under the Securities Exchange Act of 1934
                                  (Amendment No. 1)*

                               ViroPharma Incorporated
                                   (Name of Issuer)

                             Common Stock Par Value $.002
                            (Title of Class of Securities)

                                      928241108
                                    (CUSIP Number)









*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


<PAGE>



Cusip No. 928241108                 13G                     Page 2 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Oak Investment Partners VI, Limited Partnership
06-1412578
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

Delaware
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        1,537,139 shares of
Shares                                       common stock
Bene-          
ficially       (6)  Shared Voting Power      Not applicable 
Owned by 
Each           (7)  Sole Dispositive Power   1,537,139 shares of
Reporting                                    common stock
Person         
With           (8)  Shared Dispositive Power Not applicable 
          
          
- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

1,537,139 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

13.4%

- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

PN


<PAGE>



Cusip No. 928241108                 13G                     Page 3 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Oak Associates VI, LLC
06-1462392
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

Delaware
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        Not applicable
Shares 
Bene-          (6)  Shared Voting Power      1,537,139 shares of
ficially                                     common stock
Owned by 
Each           (7)  Sole Dispositive Power   Not applicable      
Reporting 
Person         (8)  Shared Dispositive Power 1,537,139 shares of
With                                         common stock   
          
     
- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

   1,537,139 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

   13.4%

- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

   OO-LLC     

<PAGE>

Cusip No. 928241108                13G                      Page 4 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Oak VI Affiliates Fund, Limited Partnership
06-1414970
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

Delaware
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        35,864 shares of  
Shares                                       common stock
Bene-
ficially       (6)  Shared Voting Power      Not applicable
Owned by 
Each           (7)  Sole Dispositive Power   35,864 shares of
Reporting                                    common stock
Person 
With           (8)  Shared Dispositive Power Not applicable
     
     
     
- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

35,864 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

0.3%

- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

PN     


<PAGE>

Cusip No. 928241108                   13G                   Page 5 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Oak VI Affiliates, LLC
06-1414968
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

Delaware
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        Not applicable
Shares 
Bene-          (6)  Shared Voting Power      35,864 shares of
ficially                                     common stock
Owned by 
Each           (7)  Sole Dispositive Power   Not applicable
Reporting 
Person         (8)  Shared Dispositive Power 35,864 shares of
With                                         common stock
     
- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

35,864 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

0.3%


- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

OO-LLC


<PAGE>

Cusip No. 92841108              13G                         Page 6 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Oak Management Corporation
06-0990851
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

Delaware
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        Not applicable
Shares 
Bene-          (6)  Shared Voting Power      1,573,003 shares of
ficially                                     common stock
Owned by 
Each           (7)  Sole Dispositive Power   Not applicable
Reporting 
Person         (8)  Shared Dispositive Power 1,573,003 shares of
With                                         common stock
     
- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

1,573,003 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

13.7%

- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

CO     

<PAGE>

Cusip No. 928241108             13G                         Page 7 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Bandel L. Carano
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

United States
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        Not applicable
Shares 
Bene-          (6)  Shared Voting Power      1,573,003 shares of
ficially                                     common stock
Owned by 
Each           (7)  Sole Dispositive Power   Not applicable
Reporting 
Person         (8)  Shared Dispositive Power 1,573,003 shares of
With                                         common stock
     
- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

1,573,003 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

13.7%

- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

IN      


<PAGE>

Cusip No. 928241108             13G                         Page 8 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Gerald R. Gallagher
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

United States
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        Not applicable 
Shares 
Bene-          (6)  Shared Voting Power      1,573,003 shares of
ficially                                     common stock                  
Owned by 
Each           (7)  Sole Dispositive Power   Not applicable 
Reporting 
Person         (8)  Shared Dispositive Power 1,573,003 shares of
With                                         common stock

- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

1,573,003 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

13.7%

- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

IN 

<PAGE>
     

Cusip No. 928241108             13G                         Page 9 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Edward F. Glassmeyer
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

United States
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        Not applicable
Shares 
Bene-          (6)  Shared Voting Power      1,573,003 shares of
ficially                                     common stock
Owned by 
Each           (7)  Sole Dispositive Power   Not applicable
Reporting 
Person         (8)  Shared Dispositive Power 1,573,003 shares of
With                                         common stock
     
- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

1,573,003 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

13.7%

- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

IN


<PAGE>

Cusip No. 928241108            13G                         Page 10 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Fredric W. Harman
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

United States
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        Not applicable
Shares 
Bene-          (6)  Shared Voting Power      1,573,003 shares of
ficially                                     common stock
Owned by 
Each           (7)  Sole Dispositive Power   Not applicable 
Reporting 
Person         (8)  Shared Dispositive Power 1,573,003 shares of 
With                                         common stock
          
- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

1,573,003 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

13.7%

- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

IN     


<PAGE>


Cusip No. 928241108             13G                        Page 11 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Ann H. Lamont
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

United States
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        Not applicable 
Shares 
Bene-          (6)  Shared Voting Power      1,573,003 shares of
ficially                                     common stock 
Owned by 
Each           (7)  Sole Dispositive Power   Not applicable
Reporting 
Person         (8)  Shared Dispositive Power 1,573,003 shares of
With                                         common stock
     
- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

1,573,003 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

13.7%

- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

IN     


<PAGE>

Cusip No. 928241108            13G                         Page 12 of 19 Pages

1  Names of Reporting Persons 
   S.S. or I.R.S. Identification Nos. of Above Persons

Eileen M. More
- --------------------------------------------------------------------------------

2 Check the Appropriate Box if a Member of a Group (See Instructions)
                                                                       (a) [   ]
                                                                       (b) [   ]
- --------------------------------------------------------------------------------
3 SEC Use Only


- --------------------------------------------------------------------------------

4 Citizenship or Place of Organization

United States
- --------------------------------------------------------------------------------
Number of      (5)  Sole Voting Power        Not applicable
Shares 
Bene-          (6)  Shared Voting Power      1,573,003 shares of
ficially                                     common stock 
Owned by 
Each           (7)  Sole Dispositive Power   Not applicable 
Reporting 
Person         (8)  Shared Dispositive Power 1,573,003 shares of
With                                         common stock
     
- --------------------------------------------------------------------------------
9  Aggregate Amount Beneficially Owned by Each
   Reporting Person

1,573,003 shares of common stock     
- --------------------------------------------------------------------------------
10 Check if the Aggregate Amount in Row (9) Excludes
   Certain Shares (See Instructions)                                       [   ]

- --------------------------------------------------------------------------------
11 Percent of Class Represented by Amount in Row 9

13.7%

- --------------------------------------------------------------------------------
12 Type of Reporting Person (See Instructions)

IN     

<PAGE>

                                                             Page 13 of 19 pages

                                     Schedule 13G
                                   Amendment No. 1
                            Common Stock, Par Value $.002
                                 CUSIP No. 928241108

Item 1(a)      Name of Issuer:
                    ViroPharma Incorporated

Item 1(b)      Address of Issuer's Principal Executive Offices:
                    76 Great Valley Parkway
                    Malvern, PA 19355

Item 2(a)      Name of Person filing:

     Oak Investment Partners VI, Limited Partnership
     Oak Associates VI, LLC
     Oak VI Affiliates Fund, Limited Partnership
     Oak VI Affiliates, LLC
     Oak Management Corporation
     Bandel L. Carano
     Gerald R. Gallagher
     Edward F. Glassmeyer
     Fredric W. Harman
     Ann H. Lamont
     Eileen M. More

Item 2(b)      Address of Principal Business Office or, if none, Residence:

     c/o Oak Management Corporation
     One Gorham Island
     Westport, CT 06880

Item 2(c)      Citizenship:

     Please refer to Item 4 on each cover sheet for each filing person
     
Item 2(d)      Title of Class of Securities:

     Common stock, $.002 par value


Item 2(e)      CUSIP Number: 928241108

Item 3         Not Applicable.

Item 4         Ownership.

<PAGE>


     The approximate percentages of shares of Common Stock reported as
     beneficially owned by the Reporting Entities is based upon 11,463,106
     shares outstanding as of November 10, 1997, as reported in the Issuer's
     Quarterly Report on Form 10-Q for the Fiscal Quarter ended September 30,
     1997.

     Please see Items 5, 6, 7, 8, 9 and 11 for each cover sheet for each filing
entity.

Item 5         Ownership of Five Percent or Less of a Class.

     Not applicable

Item 6         Ownership of More than Five Percent on Behalf of Another Person.

     Not applicable

Item 7         Identification and Classification of the Subsidiary Which
               Acquired the Security Being Reported on By the Parent Holding
               Company.

     Not applicable

Item 8         Identification and Classification of Members of the Group.

     Not applicable

Item 9         Notice of Dissolution of Group.

     Not applicable

Item 10        Certification.

     Not applicable

<PAGE>


Signature

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated February 12 1998

                              Oak Investment Partners VI,
                              Limited Partnership

                              By:  Oak Associates VI, LLC,
                                   As General Partner


                              By:  /s/ Edward F. Glassmeyer       
                                 -------------------------
                                   Managing Member

                              Oak Associates VI, LLC


                              By:  /s/ Edward F. Glassmeyer       
                                 -------------------------
                                   Managing Member


                              Oak VI Affiliates Fund,
                              Limited Partnership

                              By:  Oak VI Affiliates, LLC,
                                   As General Partner


                              By:  /s/ Edward F. Glassmeyer       
                                 -------------------------
                                   Managing Member

                              Oak VI Affiliates, LLC


                              By:  /s/ Edward F. Glassmeyer       
                                 -------------------------
                                   Managing Member


<PAGE>




                              OAK MANAGEMENT CORPORATION


                         By:  /s/ Edward F. Glassmeyer            
                             ----------------------------
                              Name:  Edward F. Glassmeyer
                              Title: President



                              /s/ Bandel L. Carano                
                             ----------------------------
                              Bandel L. Carano



                              /s/ Fredric W. Harman               
                             ----------------------------
                              Fredric W. Harman



                              /s/ Gerald R. Gallagher             
                             ----------------------------
                              Gerald R. Gallagher



                              /s/ Edward F. Glassmeyer            
                             ----------------------------
                              Edward F. Glassmeyer



                              /s/ Ann H. Lamont                   
                             ----------------------------
                              Ann H. Lamont



                              /s/ Eileen M. More                  
                             ----------------------------
                              Eileen M. More



<PAGE>




                                  INDEX TO EXHIBITS


                                                       Page


EXHIBIT A           Agreement of Reporting Persons     18


<PAGE>

                                      Exhibit A

     Each of the undersigned hereby agrees that Amendment No. 1 to the Schedule
13G filed on the date hereof with respect to the shares of Common Stock of
ViroPharma Incorporated has been filed on behalf of the undersigned.

Signature:


     Dated February 12, 1998


                              Oak Investment Partners VI,
                              Limited Partnership

                              By:  Oak Associates VI, LLC,
                                   As General Partner


                              By:  /s/ Edward F. Glassmeyer       
                                   ------------------------
                                   Managing Member

                              Oak Associates VI, LLC


                              By:  /s/ Edward F. Glassmeyer                
                                   ------------------------
                                   Managing Member


                              Oak VI Affiliates Fund,
                              Limited Partnership

                              By:  Oak VI Affiliates, LLC,
                                   As General Partner


                              By:  /s/ Edward F. Glassmeyer       
                                   ------------------------
                                   Managing Member

                              Oak VI Affiliates, LLC


                              By:  /s/ Edward F. Glassmeyer       
                                   ------------------------
                                   Managing Member


<PAGE>



                              OAK MANAGEMENT CORPORATION



                         By:  /s/ Edward F. Glassmeyer            
                              ------------------------
                              Name:  Edward F. Glassmeyer
                              Title: President



                              /s/ Bandel L. Carano                
                              ------------------------
                              Bandel L. Carano



                              /s/ Fredric W. Harman               
                              ------------------------
                              Fredric W. Harman




                              /s/ Gerald R. Gallagher             
                              ------------------------
                              Gerald R. Gallagher



                              /s/ Edward F. Glassmeyer            
                              ------------------------
                              Edward F. Glassmeyer



                              /s/ Ann H. Lamont                   
                              ------------------------
                              Ann H. Lamont



                              /s/ Eileen M. More                  
                              ------------------------
                              Eileen M. More




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