UROCOR INC
S-1/A, 1996-05-16
MEDICAL LABORATORIES
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<PAGE>
   
      AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 16, 1996
    
                                               REGISTRATION NUMBER 333-3182
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------
 
   
                                AMENDMENT NO. 3
                                       TO
                                    FORM S-1
    
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                            ------------------------
 
                                  UROCOR, INC.
             (Exact name of registrant as specified in its charter)
 
<TABLE>
<S>                               <C>                               <C>
            DELAWARE                            8071                           75-2117882
(State or other jurisdiction of     (Primary Standard Industrial    (I.R.S. Employer Identification
 incorporation or organization)     Classification Code Number)                   No.)
</TABLE>
 
                              800 RESEARCH PARKWAY
                         OKLAHOMA CITY, OKLAHOMA 73104
                                  405/290-4000
    (Address, including zip code, and telephone number, including area code,
                  of registrant's principal executive offices)
 
                              WILLIAM A. HAGSTROM
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                                  UROCOR, INC.
                              800 RESEARCH PARKWAY
                         OKLAHOMA CITY, OKLAHOMA 73104
                                  405/290-4000
 (Name, address, including zip code, and telephone number, including area code,
                             of agent for service)
                            ------------------------
 
                                   COPIES TO:
 
<TABLE>
<S>                                             <C>
            ROBERT E. WILSON, ESQ.                          MARK P. TANOURY, ESQ.
         FULBRIGHT & JAWORSKI L.L.P.               COOLEY GODWARD CASTRO HUDDLESON & TATUM
          1301 MCKINNEY, SUITE 5100                3000 SAND HILL ROAD, BLDG. 3, SUITE 230
          HOUSTON, TEXAS 77010-3095                      MENLO PARK, CALIFORNIA 94025
                 713/651-5151                                    415/843-5000
</TABLE>
 
                            ------------------------
 
    APPROXIMATE  DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: AS SOON AS
PRACTICABLE AFTER THIS REGISTRATION STATEMENT BECOMES EFFECTIVE.
                            ------------------------
 
    THE REGISTRANT HEREBY  AMENDS THIS  REGISTRATION STATEMENT ON  SUCH DATE  OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE  A  FURTHER  AMENDMENT  WHICH SPECIFICALLY  STATES  THAT  THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE  IN ACCORDANCE WITH SECTION 8(A)  OF
THE  SECURITIES ACT  OF 1933, AS  AMENDED, OR UNTIL  THIS REGISTRATION STATEMENT
SHALL BECOME EFFECTIVE ON SUCH DATE  AS THE COMMISSION, ACTING PURSUANT TO  SAID
SECTION 8(A), MAY DETERMINE.
 
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>
                                  UROCOR, INC.
 
                             CROSS-REFERENCE SHEET
                  (PURSUANT TO ITEM 501(B) OF REGULATION S-K)
 
<TABLE>
<CAPTION>
FORM S-1 ITEM AND CAPTION                                                    LOCATION OR PROSPECTUS CAPTION
- ----------------------------------------------------------------  -----------------------------------------------------
<C>        <S>                                                    <C>
       1.  Forepart of the Registration Statement and Outside
            Front Cover Page of Prospectus......................  Facing page of Registration Statement; Cross
                                                                   Reference Sheet; Outside Front Cover Page of
                                                                   Prospectus
       2.  Inside Front and Outside Back Cover Pages of
            Prospectus..........................................  Inside Front Cover and Outside Back Cover Pages of
                                                                   Prospectus
       3.  Summary Information, Risk Factors and Ratio of
            Earnings to Fixed Charges...........................  Prospectus Summary; Risk Factors
       4.  Use of Proceeds......................................  Use of Proceeds; Management's Discussion and Analysis
                                                                   of Financial Condition and Results of Operations
       5.  Determination of Offering Price......................  Underwriting
       6.  Dilution.............................................  Risk Factors; Dilution
       7.  Selling Security Holders.............................                            *
       8.  Plan of Distribution.................................  Outside Front Cover Page of Prospectus; Underwriting
       9.  Description of Securities to Be Registered...........  Capitalization; Description of Capital Stock
      10.  Interests of Named Experts and Counsel...............                            *
      11.  Information with Respect to the Registrant...........  Outside Front Cover Page of Prospectus; Prospectus
                                                                   Summary; Risk Factors; The Company; Use of Proceeds;
                                                                   Dividend Policy; Capitalization; Selected Financial
                                                                   Data; Management's Discussion and Analysis of
                                                                   Financial Condition and Results of Operations;
                                                                   Business; Management; Certain Transactions; Security
                                                                   Ownership of Management and Principal Stockholders;
                                                                   Description of Capital Stock; Shares Eligible for
                                                                   Future Sale; Financial Statements
      12.  Disclosure of Commission Position on Indemnification
            for Securities Act Liabilities......................                            *
</TABLE>
 
- ------------------------
*Item  is omitted  either because  it is inapplicable  or the  answer thereto is
negative.
<PAGE>
INFORMATION   CONTAINED  HEREIN  IS  SUBJECT   TO  COMPLETION  OR  AMENDMENT.  A
REGISTRATION STATEMENT  RELATING TO  THESE SECURITIES  HAS BEEN  FILED WITH  THE
SECURITIES  AND EXCHANGE  COMMISSION. THESE SECURITIES  MAY NOT BE  SOLD NOR MAY
OFFERS TO BUY BE ACCEPTED PRIOR  TO THE TIME THE REGISTRATION STATEMENT  BECOMES
EFFECTIVE.  THIS  PROSPECTUS  SHALL  NOT  CONSTITUTE AN  OFFER  TO  SELL  OR THE
SOLICITATION OF AN OFFER TO BUY NOR SHALL THERE BE ANY SALE OF THESE  SECURITIES
IN  ANY STATE IN WHICH SUCH OFFER,  SOLICITATION OR SALE WOULD BE UNLAWFUL PRIOR
TO REGISTRATION OR QUALIFICATION UNDER THE SECURITIES LAWS OF ANY SUCH STATE.
<PAGE>
   
                   SUBJECT TO COMPLETION, DATED MAY 16, 1996
    
 
                                2,800,000 SHARES
 
                                     [LOGO]
 
                                  COMMON STOCK
 
    ALL OF THE 2,800,000 SHARES OF COMMON  STOCK, PAR VALUE $.01 PER SHARE  (THE
"COMMON  STOCK"), OFFERED HEREBY (THE "OFFERING") ARE BEING SOLD BY UROCOR, INC.
("UROCOR" OR THE  "COMPANY"). PRIOR TO  THE OFFERING, THERE  HAS BEEN NO  PUBLIC
MARKET FOR THE COMMON STOCK. IT CURRENTLY IS ANTICIPATED THAT THE INITIAL PUBLIC
OFFERING  PRICE WILL BE  BETWEEN $8.00 AND $10.00  PER SHARE. SEE "UNDERWRITING"
FOR FACTORS TO BE CONSIDERED IN  DETERMINING THE INITIAL PUBLIC OFFERING  PRICE.
THE  COMMON STOCK HAS  BEEN APPROVED FOR  LISTING ON THE  NASDAQ NATIONAL MARKET
UNDER THE SYMBOL "UCOR".
 
                              -------------------
 
    AN INVESTMENT IN THE SHARES OF  COMMON STOCK OFFERED HEREBY INVOLVES A  HIGH
DEGREE  OF RISK.  SEE "RISK  FACTORS" BEGINNING  ON PAGE  5 FOR  A DISCUSSION OF
CERTAIN FACTORS  THAT SHOULD  BE  CONSIDERED BY  PROSPECTIVE PURCHASERS  OF  THE
COMMON STOCK.
 
                               -----------------
 
THESE  SECURITIES HAVE NOT  BEEN APPROVED OR DISAPPROVED  BY THE SECURITIES AND
 EXCHANGE  COMMISSION  OR  ANY  STATE  SECURITIES  COMMISSION  NOR  HAS   THE
   SECURITIES  AND EXCHANGE  COMMISSION OR ANY  STATE SECURITIES COMMISSION
     PASSED  UPON  THE  ACCURACY  OR  ADEQUACY  OF  THIS  PROSPECTUS.  ANY
      REPRESENTATION    TO   THE   CONTRARY   IS   A   CRIMINAL   OFFENSE.
<TABLE>
<S>                                        <C>              <C>              <C>
- --------------------------------------------------------------------------------------------
- --------------------------------------------------------------------------------------------
 
<CAPTION>
                                                PRICE        UNDERWRITING      PROCEEDS TO
                                              TO PUBLIC      DISCOUNT (1)      COMPANY (2)
<S>                                        <C>              <C>              <C>
- --------------------------------------------------------------------------------------------
PER SHARE................................         $                $                $
TOTAL (3)................................         $                $                $
- --------------------------------------------------------------------------------------------
- --------------------------------------------------------------------------------------------
</TABLE>
 
(1)  SEE  "UNDERWRITING"  FOR  INFORMATION  CONCERNING  INDEMNIFICATION  OF  THE
    UNDERWRITERS AND OTHER MATTERS.
 
(2) BEFORE DEDUCTING EXPENSES PAYABLE BY THE COMPANY, ESTIMATED AT $600,000.
 
(3)  THE COMPANY HAS GRANTED THE UNDERWRITERS  A 30-DAY OPTION TO PURCHASE UP TO
    420,000 ADDITIONAL SHARES OF COMMON  STOCK SOLELY TO COVER  OVER-ALLOTMENTS,
    IF ANY. IF THE UNDERWRITERS EXERCISE THIS OPTION IN FULL, THE TOTAL PRICE TO
    PUBLIC,  UNDERWRITING DISCOUNT AND  PROCEEDS TO COMPANY  WILL BE $         ,
    $       AND $       , RESPECTIVELY. SEE "UNDERWRITING".
 
    THE SHARES OF  COMMON STOCK OFFERED  BY THIS PROSPECTUS  ARE OFFERED BY  THE
SEVERAL UNDERWRITERS NAMED HEREIN, SUBJECT TO RECEIPT AND ACCEPTANCE BY THEM, TO
PRIOR  SALE AND TO THEIR  RIGHT TO REJECT ANY  ORDER IN WHOLE OR  IN PART AND TO
WITHDRAW, CANCEL  OR  MODIFY THE  OFFER  WITHOUT  NOTICE. IT  IS  EXPECTED  THAT
DELIVERY  OF  THE CERTIFICATES  REPRESENTING SUCH  SHARES  WILL BE  MADE AGAINST
PAYMENT THEREFOR AT THE OFFICE OF MONTGOMERY SECURITIES ON OR ABOUT            ,
1996.
 
                              -------------------
 
MONTGOMERY SECURITIES                                     VOLPE, WELTY & COMPANY
 
                                          , 1996.
<PAGE>
                                     UROCOR
 
Urology is a medical specialty focused on prostate and bladder cancer, kidney
stones and other complex diseases or conditions. Urologists typically manage
their patient's total care, serving as diagnostician, surgeon and oncologist.
UroCor's goal is to complement its broad range of diagnostic services with
theraputic products and information systems to serve urologists throughout the
entire disease cycle.
 
               A SYSTEMATIC APPROACH TO TOTAL DISEASE MANAGEMENT
 
                              URODIAGNOSTICS GROUP
      -Urology-specific technical sales force and managed care specialists
  -Comprehensive detection, diagnostic, prognostic and monitoring capabilities
  -Advanced case reporting integrating uropathology, patient demographics and
                                clinical trends
 
<TABLE>
<S>                                            <C>
            UROTHERAPEUTICS GROUP                           DISEASE MANAGEMENT
      -License, acquire and distribute                      INFORMATION SYSTEMS
        urology therapeutic products                 -Implementing on-line network for
     -Inventory and logistics management               real-time communication flow
     along with reimbursement assistance        -Expanding disease pathway models, practice
      -Oncology-directed consultation,            guidelines and decision support systems
       databases and outcome tracking          -Databases of patient demographics, clinical
                                                                 findings
                                                        and archived specimen banks
</TABLE>
 
                               UROSCIENCES GROUP
              -Focus on technology solutions to clinical dilemmas
        -Internal development of new diagnostic and information products
 -Active collaborations with leading academic and medical research institutions
 
DESCRIPTION OF ARTWORK:
 
    The  background of the entire page is  a body of water. Underneath the first
paragraph are five balls,  arranged from left  to right, over  each of which  is
centered  a word (Detection, Diagnosis,  Prognosis, Therapy and Monitoring, from
left to right). Between each  of the balls is a  small triangle, pointed to  the
right.  Underneath the balls is a box,  which contains the caption "A Systematic
Approach to Total Disease Management". Arrows from this caption are directed  to
each of the balls. Also in the box, in clockwise order, is a description of each
of the UroDiagnostics Group, Disease Management Information Systems, UroSciences
Group and UroTherapeutics Group. Arrows pointing in both directions link each of
such descriptions.
 
    IN  CONNECTION WITH THIS OFFERING, THE UNDERWRITERS MAY OVER-ALLOT OR EFFECT
TRANSACTIONS THAT STABILIZE OR MAINTAIN THE MARKET PRICE OF THE COMMON STOCK  OF
THE  COMPANY AT  A LEVEL ABOVE  THAT WHICH  MIGHT OTHERWISE PREVAIL  IN THE OPEN
MARKET. SUCH TRANSACTIONS MAY BE EFFECTED ON THE NASDAQ NATIONAL MARKET, IN  THE
OVER-THE-COUNTER  MARKET OR  OTHERWISE. SUCH  STABILIZING, IF  COMMENCED, MAY BE
DISCONTINUED AT ANY TIME.
 
                                       2
<PAGE>
                               PROSPECTUS SUMMARY
 
    THE  FOLLOWING SUMMARY  IS QUALIFIED  IN ITS  ENTIRETY BY  THE MORE DETAILED
INFORMATION, INCLUDING  THE FINANCIAL  STATEMENTS AND  NOTES THERETO,  APPEARING
ELSEWHERE  IN THIS PROSPECTUS. UNLESS OTHERWISE NOTED, THE INFORMATION CONTAINED
IN THIS PROSPECTUS ASSUMES (I)  NO EXERCISE OF THE UNDERWRITERS'  OVER-ALLOTMENT
OPTION  AND  (II) THE  AUTOMATIC  CONVERSION OF  ALL  OUTSTANDING SHARES  OF THE
COMPANY'S PREFERRED STOCK, CLASS A STOCK AND CLASS B STOCK INTO SHARES OF COMMON
STOCK IMMEDIATELY PRIOR TO THE CLOSING OF THE OFFERING.
 
                                  THE COMPANY
 
    UroCor provides  a  broad range  of  diagnostic services  for  the  clinical
management  of certain urological cancers and diseases. The Company's goal is to
complement its  diagnostic services  with therapeutic  products and  information
systems  in order to  become the leading disease  management company serving the
urology market. Through its  four business groups, UroDiagnostics,  UroSciences,
UroTherapeutics  and  Disease  Management Information  Systems,  the  Company is
developing an  integrated disease  management  approach to  serve the  needs  of
urologists  and managed  care organizations  for the  diagnostic, prognostic and
therapeutic care  of patients  throughout a  disease cycle.  The  UroDiagnostics
Group  provides diagnostic  services to  over 1,400  urologists nationwide. This
group provides  comprehensive diagnostic  services  to detect  major  urological
diseases,  predict prognosis of  the patient's condition,  monitor the patient's
therapy and identify recurrence of the disease. The UroSciences Group's goal  is
to  become a  leader in the  development and application  of advanced diagnostic
technologies and  information resources  for managing  urological diseases.  The
UroTherapeutics  Group was  established to  acquire rights  to sell  through the
Company's existing sales force urological pharmaceutical products for use in the
urologist's office. The Disease Management Information Systems group is designed
to provide  urologists  and  managed  care  organizations  with  access  to  the
Company's proprietary urological disease database, disease management models and
practice  management guidelines in order to  improve the diagnosis and treatment
of patients.
 
    UroCor serves the segment of the United States urology market consisting  of
over 7,500 office-based urologists, including those affiliated with managed care
organizations.  These  urologists diagnose  and  treat prostate  cancer, bladder
cancer,  kidney  stone  disease  and  other  complex  urological  diseases.   An
independent  survey estimated that  in 1993 there  were approximately 15 million
urology patient  visits  in  the  United States.  The  American  Cancer  Society
estimates that approximately 300,000 new cases of prostate cancer and 52,000 new
cases of bladder cancer will be diagnosed in 1996, resulting in medical costs in
excess  of  $5.0  billion.  The  Company believes  that  the  urology  market is
particularly well-suited for an  integrated disease management approach  because
of the distinctive characteristics of urological diseases and the multiple roles
of  the urologist. Urological diseases typically require extensive and prolonged
diagnosis, prognosis and monitoring throughout the  course of the disease. As  a
result,  unlike  most other  medical specialties,  the urologist  often fulfills
almost all  patient  care  needs  by acting  as  diagnostician,  oncologist  and
surgeon.  UroCor believes that  it is the  first company focusing  solely on the
urology market to offer comprehensive products and services necessary to  manage
urological diseases.
 
    To  achieve its goal  of becoming the leading  disease management company in
the urology  market, the  Company is  employing these  strategies: (i)  increase
market  penetration  of office-based  urologists,  (ii) expand  use  of existing
product lines, (iii) expand  total product offering  and (iv) strengthen  market
ties  with on-line systems. To achieve increased market penetration and expanded
product use,  the  Company  has  developed  a  direct  sales  force  focused  on
urologists'  offices and managed care organizations. To expand its total product
offering, the Company intends to develop and license technologies and  products.
In  December  1994, the  Company licensed  exclusive United  States distribution
rights from IAF BioVac,  Inc., a subsidiary of  BioChem Pharma, Inc.  ("BioVac")
for a strain of BACILLUS Calmette Guerin ("BCG"), a therapeutic product to treat
certain  types of bladder cancer for  which BioVac currently is seeking approval
from the United States  Food and Drug Administration  (the "FDA") for  marketing
approval.  To strengthen its  ties with urologists, the  Company is developing a
urology-focused, secure wide area network  that will allow urologists access  to
patient  diagnostic  results  as  well  as  the  Company's  proprietary  disease
management models.
 
                                       3
<PAGE>
                                  THE OFFERING
 
<TABLE>
<S>                                                 <C>
Common Stock offered by the Company...............  2,800,000 shares
Common Stock to be outstanding after the
 Offering.........................................  9,365,248 shares(1)
Use of proceeds...................................  Development of new products, expansion
                                                    of business lines, certain capital
                                                    expenditures and working capital and
                                                    other general corporate purposes
Proposed Nasdaq National Market symbol............  UCOR
</TABLE>
 
- ------------------------
(1) Excludes  1,487,904  shares  of  Common  Stock  issuable  upon  exercise  of
    outstanding options and warrants.
 
                             SUMMARY FINANCIAL DATA
                     (IN THOUSANDS, EXCEPT PER SHARE DATA)
 
<TABLE>
<CAPTION>
                                                                                                     THREE MONTHS ENDED
                                                            YEAR ENDED DECEMBER 31,                      MARCH 31,
                                             -----------------------------------------------------  --------------------
                                               1991       1992       1993       1994       1995       1995       1996
                                             ---------  ---------  ---------  ---------  ---------  ---------  ---------
<S>                                          <C>        <C>        <C>        <C>        <C>        <C>        <C>
STATEMENT OF OPERATIONS DATA:
Revenue....................................  $   2,145  $   4,813  $   9,348  $  14,531  $  19,758  $   4,619  $   5,908
Operating expenses:
  Direct cost of services and products.....      1,161      2,019      3,893      5,891      7,354      1,658      2,138
  Selling, general and administrative
   expenses................................      2,127      3,796      6,308      8,765      9,423      2,255      2,862
  Research and development.................        416        552      1,252      1,969      2,267        558        644
                                             ---------  ---------  ---------  ---------  ---------  ---------  ---------
    Total operating expenses...............      3,704      6,367     11,453     16,625     19,044      4,471      5,644
                                             ---------  ---------  ---------  ---------  ---------  ---------  ---------
  Income (loss) from operations............     (1,559)    (1,554)    (2,105)    (2,094)       714        148        264
Other income (expense).....................         93         42        (63)      (203)      (181)       (56)       (33)
                                             ---------  ---------  ---------  ---------  ---------  ---------  ---------
Net income (loss)..........................  $  (1,466) $  (1,512) $  (2,168) $  (2,297) $     533  $      92  $     231
                                             ---------  ---------  ---------  ---------  ---------  ---------  ---------
                                             ---------  ---------  ---------  ---------  ---------  ---------  ---------
Pro forma net income (loss) per share(1)...  $    (.61) $    (.37) $    (.41) $    (.38) $     .07  $     .01  $     .03
                                             ---------  ---------  ---------  ---------  ---------  ---------  ---------
                                             ---------  ---------  ---------  ---------  ---------  ---------  ---------
Shares used in computing pro forma net
 income (loss) per share(1)................      2,396      4,093      5,233      6,104      7,296      6,588      7,523
                                             ---------  ---------  ---------  ---------  ---------  ---------  ---------
                                             ---------  ---------  ---------  ---------  ---------  ---------  ---------
</TABLE>
 
<TABLE>
<CAPTION>
                                                                                              MARCH 31, 1996
                                                                                        --------------------------
                                                                                          ACTUAL    AS ADJUSTED(2)
                                                                                        ----------  --------------
<S>                                                                                     <C>         <C>
BALANCE SHEET DATA:
Cash and cash equivalents.............................................................  $    1,301    $   24,137
Working capital.......................................................................       5,086        27,922
Total assets..........................................................................      12,034        34,870
Long-term debt........................................................................         950           950
Accumulated deficit...................................................................     (14,124)      (14,124)
Total stockholders' equity............................................................       8,702        31,538
</TABLE>
 
- --------------------------
 
(1) Computed on the basis described in Note 2 to the Financial Statements.
 
(2)  Adjusted to reflect  the sale of  2,800,000 shares of  Common Stock offered
    hereby at an assumed  initial public offering price  of $9.00 per share  and
    the  receipt of the estimated net  proceeds therefrom. See "Use of Proceeds"
    and "Capitalization".
 
                                       4
<PAGE>
                                  RISK FACTORS
 
    AN  INVESTMENT IN THE COMMON STOCK OFFERED  HEREBY INVOLVES A HIGH DEGREE OF
RISK. THE FOLLOWING FACTORS  SHOULD BE CONSIDERED  CAREFULLY, TOGETHER WITH  THE
INFORMATION  PROVIDED ELSEWHERE IN THIS  PROSPECTUS, IN EVALUATING AN INVESTMENT
IN THE SHARES OF COMMON STOCK OFFERED HEREBY.
 
REORGANIZATION; HISTORY OF LOSSES; LIMITED HISTORY OF PROFITABLE OPERATIONS
 
    As a result  of certain litigation  and the Company's  inability to  achieve
commercial  viability, in  1990 the  Company filed  a reorganization  plan under
Chapter 11  of the  United States  Bankruptcy Code  which was  confirmed by  the
bankruptcy  court  in  1991.  In  the  reorganization,  creditors'  claims  were
discharged, certain litigation claims were settled and the rights and  interests
of the Company's equity holders were terminated. See "The Company".
 
    The Company recorded net losses of approximately $1.5 million, $1.5 million,
$2.2  million and $2.3 million for the years ended December 31, 1991, 1992, 1993
and 1994, respectively. While  the Company reported net  income of $0.5  million
for  the year ended  December 31, 1995, and  net income of  $0.2 million for the
three months ended  March 31,  1996, the Company  may experience  losses in  the
future  until  such  time,  if ever,  as  its  operations  consistently generate
sufficient revenue to cover  its costs. At  March 31, 1996,  the Company had  an
accumulated deficit of $14.1 million. There can be no assurance that the Company
will  ever be consistently profitable. See "Management's Discussion and Analysis
of Financial Condition and Results of Operations".
 
NEED FOR FUTURE FUNDING; UNCERTAINTY OF ACCESS TO CAPITAL
 
    To remain  competitive,  the  Company  must  continue  to  make  significant
expenditures  for  expansion  of  its  operations,  including  expenditures  for
diagnostic product development, acquisitions of therapeutic products,  marketing
resources  and  information  systems capabilities.  In  addition,  the Company's
growth since 1991 has required, and any future growth will require,  significant
amounts  of working  capital. The  Company believes  that the  proceeds from the
Offering, together  with  existing cash  balances,  cash flow  from  operations,
capital  leases and an existing  bank credit facility, will  be adequate to fund
its anticipated capital expenditures and working  capital needs for the next  24
months.  After that 24-month period, however, the Company may require additional
equity or debt financing to meet its working capital requirements. There can  be
no  assurance  that  additional  capital  will not  be  required  sooner  or, if
required, that it will be available on  a timely basis or on terms  satisfactory
to  the  Company. The  inability of  the Company  to obtain  adequate additional
financing on reasonable terms when needed  would have a material adverse  effect
on  the Company's financial  condition and results  of operations. If additional
funds are  raised through  the  issuance of  equity securities,  the  percentage
ownership of then current stockholders of the Company would be reduced. Further,
such  equity securities  may have  rights, preferences  or privileges  senior to
those  of  the   Common  Stock.   See  "Use   of  Proceeds",   "Capitalization",
"Management's  Discussion  and Analysis  of Financial  Condition and  Results of
Operations" and "Description of Capital Stock".
 
UNCERTAINTIES RELATED TO THIRD-PARTY REIMBURSEMENT; POTENTIAL HEALTH CARE REFORM
 
    The Company typically bills governmental programs such as Medicare and other
third-party payors such  as private  insurance and  managed care  plans for  its
products  and  services. Such  third-party  payors are  increasingly negotiating
prices with the goal of lowering reimbursement rates. The Company expects  these
pricing  pressures,  combined with  the introduction  of new  diagnostic product
lines with  lower average  prices per  specimen, to  cause reduced  revenue  per
specimen in the future.
 
    In  1993, 1994, 1995 and the first  three months of 1996, approximately 56%,
58%, 58%  and 53%,  respectively,  of the  Company's  revenue was  derived  from
services  performed principally for  beneficiaries of the  Medicare program. For
many of  the services  performed for  Medicare beneficiaries,  the Company  must
accept reimbursement from Medicare as payment in full, subject to applicable co-
payments and deductibles. Reimbursement rates have been established for most but
not  all of the services performed by  the Company. The Company, however, cannot
collect from Medicare or other third-party payors for services that those payors
have not approved for reimbursement. Approval of
 
                                       5
<PAGE>
such services by Medicare or other federal agencies does not ensure approval  by
other  third-party payors. A formal  determination for reimbursement approval is
made, however, with respect to  relatively few new procedures. Most  third-party
payors,  including Medicare,  do not  cover services  that they  determine to be
experimental, investigational  or otherwise  not  reasonable and  necessary  for
diagnosis  or  treatment.  There can  be  no  assurance that  the  Company's new
Free/Total PSA product or any other products under development will be  approved
for  reimbursement by  Medicare or other  third-party payors.  Medicare also may
audit and  review its  prior payments  to the  Company, and  may determine  that
certain of those payments must be refunded. It is also possible that third-party
payors may cease to pay for one or more of the Company's services that currently
are  reimbursed by them. Significant disapprovals by various carriers, including
Medicare,  private  insurance  and  managed   care,  reductions  or  delays   in
establishing  reimbursement  rates  and  insurance  carrier  limitations  on the
coverage of the Company's services could  have a material adverse effect on  the
Company's  future revenue. While  the Company is  certified for participation in
the Medicare program, any loss of  such certification, whether arising from  any
action by an agency of the federal government or any other regulatory authority,
or  any  related  civil or  administrative  proceedings, would  have  a material
adverse effect on the Company's  financial condition and results of  operations.
See "Business -- Third Party Reimbursement".
 
    In  addition, since  1994, the  Company's Medicare  intermediary and certain
other third-party payors have increased the amount of time between their receipt
of claims for reimbursement and payment to  the Company. At March 31, 1996,  the
Company's  average  number of  days sales  in  receivables was  approximately 74
compared to 49 at December 31, 1994. Such delays in payments to the Company have
resulted in the Company's accounts receivable increasing at a rate greater  than
the  revenue growth rate  and, therefore, have affected  the Company's cash flow
from operations. There can  be no assurance that  these payors will not  further
modify  their payment practices,  which could have a  material adverse effect on
the Company's financial condition and  results of operations. See  "Management's
Discussion and Analysis of Financial Condition and Results of Operations".
 
    From  time to time  the public and the  federal government focus significant
attention on reforming the health care  system in the United States. Any  future
changes  in Medicare and other third-party  payor reimbursement which may result
from health care reform  or deficit reduction  legislation will likely  continue
the  downward pressure on  prices. Because of  the uncertainties surrounding the
nature, timing and extent of any such reform initiatives, the Company is  unable
to  predict the  effects of any  such changes  on the Company.  See "Business --
Government Regulation".
 
DEPENDENCE ON CERTAIN PRODUCT LINES
 
    A significant portion of the Company's revenue has been, and is expected  to
continue  to  be,  dependent upon  the  Company's prostate  tissue  analysis and
bladder cellular analysis product lines.  The Company's revenue attributable  to
prostate  tissue analysis accounted  for approximately 29%, 48%,  54% and 54% of
revenues in 1993, 1994, 1995 and  the first three months of 1996,  respectively.
The  Company's revenue attributable  to bladder cellular  analysis accounted for
approximately 53%, 36%, 30% and 26% of revenue in 1993, 1994, 1995 and the first
three months of 1996, respectively. Any negative event related to these  product
lines,  such  as  increased  competition,  pricing  pressures  and  clinical  or
technological obsolescence  would have  a  material and  adverse effect  on  the
Company's  financial  condition  and  results of  operations.  See  "Business --
Business Lines -- UroDiagnostics Group -- Products".
 
NO ASSURANCE OF SUCCESSFUL ACQUISITION OF DISTRIBUTION RIGHTS FOR THERAPEUTIC
PRODUCTS
 
    Through its UroTherapeutics Group, the  Company is developing a  therapeutic
products  distribution business. To date,  the Company has acquired distribution
rights for only  one therapeutic  product. There can  be no  assurance that  the
Company  will be successful in negotiating  any additional distribution or other
agreements related to therapeutic products in the future. The Company has  never
marketed  or distributed any therapeutic products. If its efforts in this regard
are unsuccessful,  it could  have a  material adverse  effect on  the  Company's
financial  condition and results of operations. The manufacturers of therapeutic
products are responsible for  compliance with FDA  regulations relating to  such
 
                                       6
<PAGE>
products;  thus  the  Company is  and  will  be dependent  on  others  to obtain
marketing approval  for  any  therapeutic  products  for  which  it  may  obtain
distribution  rights. The Company also will rely on third parties to manufacture
products in  a timely  fashion.  Product unavailability  could have  a  material
adverse effect on future business performance.
 
    In December 1994, the Company entered into a distribution agreement with IAF
BioVac  Inc. ("BioVac"), a subsidiary of BioChem Pharma, Inc., for a BCG product
for  use  in  treating  certain  types  of  bladder  cancer.  Pursuant  to   the
distribution  agreement, BioVac is responsible  for obtaining approvals from the
FDA for marketing the BCG product in the United States. UroCor may not  commence
selling  the product  in the  United States until  BioVac has  obtained such FDA
approval. In April  1995, BioVac filed  its initial applications  with the  FDA.
BioVac  has informed the Company that in a  letter dated April 18, 1996, the FDA
advised BioVac that its application is not approvable at this time and that  the
FDA  requested additional  data regarding  certain aspects  of manufacturing and
testing of the product. BioVac has advised the Company that notwithstanding  the
receipt  of the non-approvable letter  from the FDA, it  believes it can satisfy
FDA requirements and procure  approval for marketing the  product in the  United
States.  There can be no assurance, however,  that approval will be obtained. In
addition, if FDA approval  is obtained, to  maintain its exclusive  distribution
rights  under  the  agreement the  Company  must satisfy  certain  minimum sales
requirements. Although the Company has no reason to believe it will be unable to
satisfy those  requirements, no  assurance  can be  given  in that  regard.  See
"Business -- Business Lines -- UroTherapeutics Group".
 
    The Company's success in the distribution of therapeutic products is subject
to risks, including the possibilities that the proposed products fail to receive
necessary  regulatory approvals,  that the  proposed products  or procedures are
uneconomical to market  or do not  achieve broad market  acceptance, that  third
parties  hold proprietary rights  that preclude the  Company from marketing them
and that third parties market a superior or equivalent product. UroCor is unable
to predict whether the distribution rights it has obtained for the proposed  BCG
product  or any distribution rights  it may obtain in  the future will result in
any commercially  viable products.  Further,  due to  the extended  testing  and
regulatory  review process required  before marketing approval  can be obtained,
the development  period  for  any such  products  is  long and  the  timing  for
commercialization is uncertain.
 
UNCERTAINTY RELATED TO GOVERNMENT REGULATION
 
    The  Company's diagnostic laboratory operations currently are required to be
certified or licensed under the  federal Clinical Laboratory Improvement Act  of
1967,  as  amended in  1988  ("CLIA"), the  Medicare  and Medicaid  programs and
various state and local laws. In some instances, the Company is also subject  to
licensing  or regulation under  federal and state laws  relating to the handling
and  disposal  of  medical  specimens,   infectious  and  hazardous  waste   and
radioactive  materials,  as  well as  to  the  safety and  health  of laboratory
employees. The  sanctions  for failure  to  comply with  these  regulations  may
include  denial of the right to conduct business, significant fines and criminal
penalties. The loss of  a license, imposition  of a fine or  an increase in  the
complexity or substantive requirements of such federal, state and local laws and
regulations  could have  a material  adverse effect  on the  Company's financial
condition and results of operations. See "Business -- Government Regulation" and
"Business -- Environmental Matters".
 
    The Company's diagnostic laboratory  operations currently are not  regulated
by the FDA. While the FDA now indicates that it does not plan to regulate assays
developed  by laboratories  for in-house  use, the FDA  has in  the past drafted
guidelines for regulation of such assays. If in the future the FDA were to issue
guidelines for  the clinical  laboratory market  sector, such  guidelines  might
require the Company to meet certain FDA medical device approval requirements for
the  Company's  in-house assays.  Such  regulations, if  enacted  in a  way that
affects the Company, would increase the cost of development and approval of  new
products,  slow  their introduction  to  the market  and  could have  a material
adverse effect on the Company's  financial condition and results of  operations.
See "Business -- Government Regulation".
 
                                       7
<PAGE>
    The  FDA  currently regulates  a number  of the  products which  the Company
purchases  from  third  parties  for   use  in  its  diagnostic  services.   The
manufacturers   of  such  products  are  responsible  for  compliance  with  FDA
regulations relating to such products. There can be no assurance, however,  that
action by the manufacturers or by the FDA would not impair the Company's ability
to obtain and offer certain services. The unavailability of certain services and
materials  used  in the  Company's diagnostics  business  would have  a material
adverse effect on the Company's financial condition and results of operations.
 
    Although the Company's existing  and proposed information services  products
currently  are not subject to regulation by  the FDA, the FDA could determine in
the future that the predictive applications  of these products are deemed to  be
medical  devices subject  to FDA  regulation. In  that event,  the Company could
experience delays  in developing  and marketing  new services  and increases  in
research and development costs.
 
    As  a provider of  health care related  services, the Company  is subject to
extensive and frequently changing federal, state and local laws and  regulations
governing  licensure,  billing, financial  relationships, referrals,  conduct of
operations, purchase of existing businesses, cost-containment, direct employment
of licensed  professionals by  business corporations  and other  aspects of  the
Company's  business  relationships. The  Company  cannot predict  the  timing or
impact of any  changes in such  laws and  regulations, and no  assurance can  be
given  that any  such changes  will not  have a  material adverse  effect on the
Company's financial  condition  and  results of  operations.  See  "Business  --
Government Regulation".
 
UNCERTAINTIES RELATED TO MANAGED CARE
 
    Managed care organizations are gaining increasing control over the access to
health  care for an increasing number of patients with urological diseases. Many
of these organizations  seek to  obtain health care  service provider  contracts
with  a minimum number of large, full-service vendors for all required services,
and to obtain from such vendors large discounts or capitated contracts in  which
all  products or  services for  all their  enrolled patients  are paid  for by a
contractual monthly  fee  based  on  the number  of  patients  enrolled  in  the
organization.  The  majority  of the  Company's  managed care  contracts  may be
canceled by the managed care organization upon  30 to 60 days notice. There  can
be no assurance that the Company will be able to maintain its existing contracts
with  managed care organizations  or that it  will be able  to obtain additional
contracts with such organizations in the future which could preclude the Company
from serving large  groups of  physicians in  certain markets.  The Company  has
experienced increased pricing pressure from managed care organizations, and such
pressure  is expected to continue.  There can be no  assurance that such pricing
pressure and contract restrictions  will not have a  material adverse effect  on
the  Company's financial condition  and results of  operations. See "Business --
Third-Party Reimbursement".
 
NO ASSURANCE OF ACCESS TO AND DELIVERY OF NEW DIAGNOSTIC TECHNOLOGY
 
    The markets  for  the Company's  diagnostic  products are  characterized  by
rapidly  changing technology, frequent new product introductions and enhancement
and, therefore, rapid product obsolescence. The Company's future success will be
highly dependent upon its ability to continue to develop new diagnostic products
or services while  enhancing current  capabilities in  order to  keep pace  with
technological  advancements  in  urology. There  can  be no  assurance  that the
Company will be able to identify new products, trends or opportunities,  develop
and  bring  to market  new products,  respond  effectively to  new technological
changes or product announcements by others, develop or obtain access to advanced
materials or receive commercial acceptance for its products. In addition,  there
can  be no assurance that products or  technologies developed by others will not
render the Company's products or technologies non-competitive or obsolete.
 
    The Company's  principal  sources of  such  technology are  (i)  test  kits,
reagents  and  other products  purchased  from manufacturers,  (ii) intellectual
property, such  as  processes,  products, devices  and  software  licensed  from
academic  and research institutions,  other commercial entities  and the federal
government and (iii)  new technology  developed under  strategic alliances  with
other commercial entities
 
                                       8
<PAGE>
or  through  sponsored  or  collaborative research  programs  with  academic and
research institutes. There can be no assurance that the Company will continue to
obtain new technologies important to its business in the future. The Company may
not be able  to negotiate successfully  technology acquisition or  collaborative
arrangements  in the future. The Company may enter into such arrangements but be
unable to develop any commercially viable technologies. If the Company's  access
to and delivery of new technologies were substantially diminished, the Company's
business could be materially and adversely affected.
 
    In  March 1996, the FDA published a  proposed rule to classify or reclassify
certain reagents supplied to the Company. The impact of this proposal, if it  is
finalized,  cannot be determined  at this time.  The proposal, however, includes
requirements with which suppliers  of reagents would  need to comply,  including
the  need  to  follow  the  FDA's  Good  Manufacturing  Practices,  as  well  as
registration  and  reporting  requirements  for  suppliers.  The  proposal,   if
finalized, could therefore have an impact on the Company's cost and availability
of reagents.
 
SUBSTANTIAL COMPETITION
 
    The  industry  in  which  the  Company's  diagnostics  business  operates is
characterized by intense  competition with many  different types of  competitors
including   specialty   laboratories,   diagnostic   kit   and   instrumentation
manufacturers, local and regional pathology services, hospital laboratories  and
large general reference clinical laboratories. Many of the Company's competitors
are significantly larger and have significantly greater financial, technical and
administrative  resources  than the  Company;  many also  have  long established
relationships  with  the  Company's  current  and  prospective  customers.   See
"Business -- Competition".
 
    The  competition for the acquisition  of new diagnostic testing technologies
and therapeutic  products  is intense.  The  Company competes  with  many  other
companies  for diagnostic products and  major and other pharmaceutical companies
for therapeutic products. Many of  these companies are significantly larger  and
have significantly greater financial and other resources than the Company. There
can be no assurance that the Company will continue to be successful in acquiring
new  technologies  for use  in its  diagnostic  services business.  Although the
Company was successful in acquiring the distribution rights to the BCG  product,
the Company's first proposed therapeutic product, there can be no assurance that
it will continue to be successful in this regard. See "Business -- Competition".
 
    Competition  in  the marketing  of pharmaceutical  products is  intense. The
Company is  aware  of  two  other companies  that  already  are  distributing  a
therapeutic  product  similar  to the  Company's  proposed BCG  product.  If FDA
approval for the BCG  product is obtained,  there can be  no assurance that  the
Company  will  be  able  to  market  successfully  this  product  against  these
competitors. See "Business -- Competition".
 
    The market  for  health care  information  systems and  services  is  highly
competitive.  The  Company's  competitors include  other  providers  of outcomes
software and databases based on claims  data. Many of the Company's  competitors
and  potential  competitors have  greater  financial development,  technical and
marketing resources than  the Company, and  have substantial installed  customer
bases   in  the  health  care  industry.  The  Company  also  faces  significant
competition  from  internal  information  services  at  hospitals,  which   have
developed  their own outcomes databases. In addition, as the market for outcomes
software develops, additional competitors may  enter the market and  competition
may intensify. There can be no assurance that the Company's business will not be
materially and adversely affected by such competition. See "Business -- Business
Lines -- Disease Management Information Systems".
 
    Combinations   of  current  and  future  competitors  through  acquisitions,
mergers, alliances or marketing or distribution agreements could result in  more
intense  competition in the  future. There can  be no assurance  that current or
future competitors  will not  succeed in  developing technologies,  products  or
managed care marketing programs and capabilities that are more effective, easier
to  use or less expensive than those that  are being developed by the Company or
that would  render the  Company's technology,  products and  marketing  approach
obsolete, noncompetitive or unprofitable.
 
                                       9
<PAGE>
RISKS ASSOCIATED WITH MANAGEMENT OF GROWTH
 
    The  Company  recently  has  experienced  substantial  growth  and  expanded
significantly  its   diagnostic  services   operational  capabilities,   support
operations and research and development operations. The Company also is planning
to  offer a therapeutic  product line and information  services. This growth and
expansion has placed, and  will continue to place,  a significant strain on  the
Company's  management, production, technical, financial  and other resources. To
manage growth effectively, the Company must maintain a high level of operational
quality and efficiency, and must continue to enhance its operational,  financial
and  management systems and expand, train and manage its employee base. To date,
the Company  has experience  primarily in  managing a  diagnostics business  and
marketing  diagnostic  products.  The  Company has  no  experience  in managing,
operating or  marketing  products for  a  therapeutics or  information  services
business. There can be no assurance that the Company will be able to manage this
expansion  effectively, and any failure  to do so could  have a material adverse
effect on the Company's financial condition and results of operations.
 
POTENTIAL FLUCTUATIONS IN OPERATING RESULTS
 
    The Company's quarterly and annual operating results are affected by a  wide
variety  of factors, many of which are outside the Company's control, which have
in the past  and could in  the future materially  and adversely affect  revenue,
operating  expenses and income. These factors  include the quantities and timing
of specimens received, competitive pricing  pressures, availability and cost  of
diagnostic  supplies, changes in  the mix of  products sold, seasonality, timing
and costs of  new product  and technology introductions  by the  Company or  its
competitors,  retention and expansion of the  sales force and timing of payments
from Medicare and other third-party payors. The need for continued investment in
research and development  and expansion  of its  product lines  could limit  the
Company's  ability to reduce expenses quickly. As a result of these factors, the
Company expects  its operating  results  to continue  to fluctuate.  Results  of
operations  in any one quarter should not be considered indicative of results to
be expected for  any future period,  and fluctuations in  operating results  may
also  cause  fluctuations  in  the  market  price  for  the  Common  Stock.  See
"Management's Discussion  and Analysis  of Financial  Condition and  Results  of
Operations -- Quarterly Results of Operations".
 
UNCERTAINTY REGARDING PATENTS AND PROPRIETARY RIGHTS
 
    The  Company's  business depends  in  part upon  its  intellectual property,
including patents, copyrights, trade secrets, know-how and continuing technology
innovation. The Company licenses patents  and seeks patents when appropriate  on
inventions  concerning  new products  and improvements  as  part of  its ongoing
research, development and marketing  efforts. The Company  also intends to  seek
copyright  protection when appropriate  for any information  systems products it
may develop. There can be  no assurance that any steps  taken by the Company  to
protect  its intellectual property will be adequate to prevent misappropriation,
that any patents issued to or licensed  by the Company will not be  invalidated,
circumvented  or challenged or that the rights granted thereunder will provide a
competitive advantage. Furthermore, there can  be no assurance that others  will
not  independently  develop technologies  that are  similar  or superior  to the
Company's  technology  and  obtain  patents  or  copyrights  relating  to   such
technologies.  In  such event,  the  Company may  not  be able  to  license such
technologies on  acceptable  terms.  Although  the  Company  believes  that  its
products  and technology do not infringe  upon the proprietary rights of others,
there can be no assurance that third parties will not assert infringement claims
in the future. Moreover,  litigation may be necessary  in the future to  enforce
the  Company's patents,  copyrights and  other intellectual  property rights, to
protect the Company's trade secrets, to determine the validity and scope of  the
proprietary  rights of  others or  to defend  against claims  of infringement or
invalidity. Such litigation could result  in substantial costs and diversion  of
resources  and could have  a material adverse effect  on the Company's financial
condition and results of operations. See "Business -- Intellectual Property".
 
DEPENDENCE ON KEY PERSONNEL
 
    The Company's ability to market and deliver its products and services and to
achieve and maintain a competitive position is dependent in large part upon  the
efforts of its senior management. The loss of
 
                                       10
<PAGE>
the  services  of one  or more  members of  its senior  management could  have a
material adverse  effect on  the Company's  financial condition  and results  of
operations.  The Company's future  success also will depend  upon its ability to
attract and retain qualified management, scientific, technical and manufacturing
employees to  support  its future  growth.  Competition for  such  personnel  is
intense,  and there can be  no assurance that the  Company will be successful in
attracting or retaining such personnel. The  failure to attract and retain  such
persons  could materially adversely affect the Company's financial condition and
results of operations. See "Management".
 
POTENTIAL LIABILITIES; LIMITED INSURANCE COVERAGE
 
    Employees  of  the  Company,  like  those  of  all  companies  that  provide
diagnostic  services dealing with human blood specimens, may be exposed to risks
of infection from AIDS, hepatitis and other blood-borne diseases if  appropriate
laboratory  practices are not followed. Although no infections of this type have
been reported in the Company's history,  no assurance can be provided that  such
infections  will not occur in  the future. The Company  could also be subject to
legal actions arising out of the  misperformance of its testing services or  the
malpractice  of professional  physician services.  Any such  legal actions could
have a material adverse effect on the Company's financial condition and  results
of operations.
 
    Although the Company presently is covered by medical malpractice and general
liability  insurance, there can be no assurance that the insurance coverage will
provide sufficient funds to satisfy any judgments which could be entered against
the Company in the future  or that liability insurance  in such amounts will  be
available  or affordable in the  future. In addition, there  can be no assurance
that all of the activities encompassed within the Company's business are covered
under the Company's insurance policies. The  lack of such coverage could have  a
material  adverse effect  on the  Company's financial  condition and  results of
operations. Moreover,  although  the  Company maintains  personal  property  and
business  interruption insurance and  has taken what it  believes to be adequate
safeguards, the catastrophic loss of the Company's tissue or cell library  could
have a material adverse effect on the continued development of its database in a
manner which would not be compensated fully by insurance.
 
    The commercial sale of therapeutic products by the Company will expose it to
potential  product liability  risks that are  inherent in the  marketing of such
products for human use.  These claims might be  made directly by consumers.  The
Company  currently has no product liability  insurance, and although it plans to
obtain such insurance prior to marketing  any therapeutic product, there can  be
no  assurance that the Company will be able to obtain or maintain such insurance
on acceptable  terms  or that  such  insurance will  provide  adequate  coverage
against  potential liabilities. A product liability  claim could have a material
adverse effect on the Company's financial condition and results of operations.
 
RISKS ASSOCIATED WITH HAZARDOUS MATERIALS
 
    The Company's diagnostic  services and research  and development  activities
involve  the  controlled  use  of  hazardous  materials,  chemicals  and various
radioactive compounds. Although the Company believes that its safety  procedures
for  handling  and  disposing  of  such  materials  comply  with  the  standards
prescribed  by  state   and  federal   regulations,  the   risk  of   accidental
contamination or injury from these materials cannot be completely eliminated. In
the  event of such an accident, the Company could be held liable for any damages
that result and any  such liability could exceed  the resources of the  Company.
See "Business -- Environmental Matters".
 
IMMEDIATE AND SUBSTANTIAL DILUTION; ABSENCE OF DIVIDENDS
 
    The initial public offering price is substantially higher than the pro forma
net  tangible book  value per  share of the  Common Stock.  Purchasers of Common
Stock in  the Offering  will experience  immediate and  substantial dilution  of
$5.67  per share, assuming an initial public  offering price of $9.00 per share.
See "Dilution".
 
    The Company has  never paid cash  dividends and does  not anticipate  paying
cash  dividends on  the Common  Stock in  the foreseeable  future. See "Dividend
Policy".
 
                                       11
<PAGE>
ABSENCE OF PRIOR PUBLIC MARKET; DETERMINATION OF OFFERING PRICE; POSSIBLE
VOLATILITY OF STOCK PRICE
 
    Prior to the Offering, there has been no public market for the Common Stock.
Although the Common Stock has been  approved for listing on the Nasdaq  National
Market,  there can be no assurance that an active trading market will develop or
continue upon completion of the Offering.  The initial public offering price  of
the  Common  Stock will  be determined  by negotiations  between UroCor  and the
representatives of the  underwriters and  may not  be indicative  of the  market
price  of  the Common  Stock after  the Offering.  There has  been a  history of
significant volatility in the market prices  for shares of companies engaged  in
the  health care and biotechnology fields, and the market price of the shares of
Common Stock offered pursuant  to the Offering may  be highly volatile.  Factors
such  as fluctuations in the Company's quarterly revenues and operating results,
announcements of technological  innovations or  new analytical  services by  the
Company  and  its  competitors  and  changes  in  third-party  reimbursement and
governmental regulation may have a significant effect on the market price of the
Common Stock. For a  discussion of factors to  be considered in determining  the
initial public offering price, see "Underwriting".
 
CONTROL BY EXISTING STOCKHOLDERS; POSSIBLE ANTI-TAKEOVER EFFECTS
 
    Upon  completion of the  Offering, the Company's  existing stockholders will
own beneficially approximately 70.1% of  the Company's outstanding Common  Stock
(67.1%  if  the  Underwriters  exercise  the  over-allotment  option  in  full).
Accordingly, the  existing stockholders,  acting  as a  group,  may be  able  to
influence  the  outcome of  stockholder  votes, including  votes  concerning the
election of directors, the adoption or amendment of provisions to the  Company's
Restated   Certificate   of   Incorporation   (the   "Restated   Certificate  of
Incorporation") or Amended and Restated By-laws (the "By-laws") and the approval
of certain mergers and significant corporate transactions. These provisions  and
control  by existing stockholders  could limit the  price that certain investors
might be willing to pay  in the future for shares  of Common Stock and have  the
effect  of delaying, deferring or preventing a change in control of the Company.
See "Security Ownership of Management and Principal Stockholders".
 
    The Restated Certificate of  Incorporation and By-laws  include a number  of
provisions   that  may  have  the  effect  of  encouraging  persons  considering
unsolicited tender offers  or other unilateral  takeover proposals to  negotiate
with the Company's Board of Directors rather than pursue non-negotiated takeover
attempts.  These  provisions  include authorized  blank  check  preferred stock,
denial of cumulative voting,  limitation of the persons  who may call a  special
meeting  of  stockholders,  advance  notice  requirements  for  nominations  for
election to the  Board of  Directors and a  classified Board  of Directors.  See
"Description of Capital Stock".
 
POTENTIAL EFFECT OF SHARES ELIGIBLE FOR FUTURE SALE ON PRICE OF COMMON STOCK;
REGISTRATION RIGHTS
 
    Upon completion of the Offering, the Company will have outstanding 9,365,248
shares  of Common  Stock (9,785,248  shares if  the Underwriters' over-allotment
option is exercised in full).  The 2,800,000 shares to  be sold in the  Offering
(plus   any  additional   shares  sold   upon  exercise   of  the  Underwriters'
over-allotment option) will  be freely  tradeable in the  public market  without
restriction or further registration under the Securities Act of 1933, as amended
(the  "Securities Act"),  except for any  shares purchased by  affiliates of the
Company.
 
    The Company  and  its  executive  officers, directors  and  certain  of  the
stockholders of the Company, all of whom together beneficially own approximately
6,102,000  shares, representing  approximately 65.2%  of the  Common Stock after
giving effect to  the issuance of  the shares  of Common Stock  in the  Offering
(62.4%  if the Underwriters'  over-allotment option is  exercised in full), have
agreed that, for a period  of 180 days after the  date of this Prospectus,  they
will  not,  directly or  indirectly, offer,  sell, contract  to sell,  grant any
option to sell or  otherwise dispose of, directly  or indirectly, any shares  of
Common  Stock or securities convertible into  or exchangeable for, or any rights
to purchase  or acquire,  Common Stock,  without the  prior written  consent  of
Montgomery Securities. Montgomery Securities, in its sole discretion, and at any
time without notice, may release all or any portion of the securities subject to
the 180-day lock-up agreement.
 
                                       12
<PAGE>
    Of the 6,565,248 shares of Common Stock held by existing stockholders of the
Company,  (i)  approximately 214,000  will be  eligible for  sale in  the public
market immediately following the Offering  and (ii) an additional  approximately
5,506,000  shares will  be eligible  for sale  in the  public market immediately
following the  expiration  of the  180-day  lock-up described  above,  of  which
approximately   1,539,000  shares  are  subject  to  certain  volume  and  other
restrictions under Rule 144.
 
    As of  the date  of this  Prospectus, options  and warrants  to purchase  an
aggregate  of  1,487,904  shares  of  Common  Stock  are  outstanding  of  which
approximately 920,000 shares underlying such options and warrants are subject to
the 180-day lock-up agreement.
 
    Certain of  the Company's  existing stockholders  have certain  rights  with
respect  to  the  registration  under  the Securities  Act  of  an  aggregate of
5,886,601 shares of Common  Stock (the "Registrable  Shares"). In general,  such
stockholders  may demand on  up to two  occasions that the  Company register the
sale of their shares of Common Stock. Each holder of Registrable Shares also has
piggy-back registration rights, subject to certain limitations, in the event the
Company proposes to register the sale of any shares of Common Stock or any other
securities of  the  Company for  its  own account  or  for the  account  of  its
stockholders. The Company is obligated to bear all of the expenses in connection
with the registration of the Registrable Shares, except underwriting commissions
and  discounts. Any sales of  Registrable Shares will be  subject to the 180-day
lock-up described under "Shares Eligible for Future Sale" and "Underwriting".
 
    Prior to the Offering, there has been no public market for the Common Stock,
and no prediction can be made as to the effect, if any, that the sale of  shares
or  the availability  of shares for  sale will have  on the market  price of the
Common Stock prevailing from  time to time.  Nevertheless, sales of  substantial
amounts  of  the  Common  Stock  in the  public  market  could  adversely affect
prevailing market prices and the ability of the Company to raise equity  capital
in the future. See "Shares Eligible for Future Sale" and "Underwriting".
 
                                       13
<PAGE>
                                  THE COMPANY
 
    The   Company   was  incorporated   in  Texas   in   1985  under   the  name
CytoDiagnostics, Inc. The  Company was  reincorporated in Delaware  in 1988.  In
1994,  the  Company changed  its name  to UroCor,  Inc. The  Company's executive
offices and  operations are  located  at 800  Research Parkway,  Oklahoma  City,
Oklahoma 73104, and its telephone number is 405/290-4000.
 
    As  a result  of certain litigation  and the Company's  inability to achieve
commercial viability, in November 1990, the Company filed a reorganization  plan
under  Chapter 11 of the United States Bankruptcy Code that was confirmed by the
bankruptcy court in March  1991. In the  reorganization, creditors' claims  were
discharged,  certain litigation claims were settled and the rights and interests
of the Company's equity holders were terminated. In late 1989, the Company began
recruiting new senior management and refocused  its strategy to provide a  broad
range  of  diagnostic products  and services  intended  to improve  the clinical
management of  certain major  urological  cancers and  complex diseases  and  to
develop an integrated disease management company serving the urology market.
 
                                USE OF PROCEEDS
 
    The  net proceeds to  the Company from  the sale of  the 2,800,000 shares of
Common Stock offered by the Company pursuant to the Offering are estimated to be
approximately $22.8 million ($26.4 million, if the Underwriters'  over-allotment
option  is exercised in full), based on an assumed initial public offering price
of $9.00 per share and after  deducting the estimated underwriting discount  and
offering expenses payable by the Company.
 
    The  Company expects that approximately $19.0 million of the net proceeds of
the Offering  will be  used as  follows: approximately  $3 million  to fund  the
development  and  expansion of  its  diagnostic product  line,  approximately $3
million for the development of its urological disease data bases,  approximately
$6  million  for development  of a  therapeutic  product line,  approximately $4
million for the development and  expansion of information products and  services
and   approximately  $3  million  for   capital  expenditures  relating  to  the
development and expansion of clinical  and research laboratory capabilities  and
laboratory  information systems. The Company  believes that the amounts actually
expended for the development of a theraputic product line may vary significantly
depending primarily on the availability of appropriate products, the ability  of
the  Company  to  acquire  rights  to  such  products  and  the  availability of
appropriate joint venture or other collaboration opportunities pursuant to which
the Company may acquire rights to such products without the expenditure of cash.
The Company expects that any  portion of the $6.0  million of proceeds not  used
for  this purpose will be expended in  approximately equal amounts for the other
four anticipated principal uses of proceeds.
 
    The Company intends  to use the  remainder of the  net proceeds for  working
capital  and general corporate purposes.  The Company may also  use a portion of
such net  proceeds  to  acquire  or invest  in  businesses  with  diagnostic  or
information  products and  technologies that are  complementary to  those of the
Company, although no specific acquisitions or investments are planned as of  the
date  of this Prospectus, and no portion of such net proceeds has been allocated
for any particular  acquisition or  investment. Pending such  uses, the  Company
intends  to invest the aggregate net  proceeds from this Offering in short-term,
investment-grade, interest-bearing securities.
 
    The Company estimates that its existing capital resources, the net  proceeds
from  the  Offering  and  interest thereon,  together  with  bank  and equipment
financing, will be sufficient to fund  the Company's requirements for 24  months
following the closing of the Offering. See "Management's Discussion and Analysis
of  Financial  Condition  and Results  of  Operations --  Liquidity  and Capital
Resources".
 
                                DIVIDEND POLICY
 
    UroCor has never declared  or paid any cash  dividends on its Common  Stock.
The  Company intends to  retain any future  earnings for the  development of its
business. Accordingly, the Company does not anticipate paying cash dividends  on
the  Common Stock in the foreseeable  future. The Company's existing bank credit
facility currently  prohibits  the  payment  of  dividends.  Under  the  General
Corporation Law of the State of Delaware, a corporation's board of directors may
declare and pay dividends only out of surplus or current net profits.
 
                                       14
<PAGE>
                                 CAPITALIZATION
 
   
    The  following  table  sets  forth  as of  March  31,  1996  (i)  the actual
capitalization of the Company, (ii) the pro forma capitalization of the  Company
to  give effect  to the  automatic conversion of  all outstanding  shares of the
Company's Preferred Stock, Class A Stock and Class B Stock into shares of Common
Stock immediately prior to the closing of  the Offering and (iii) the pro  forma
capitalization of the Company, as adjusted, to reflect the issuance of 2,800,000
shares  of Common Stock pursuant to the Offering at an assumed offering price of
$9.00 per  share and  after deducting  the underwriting  discount and  estimated
offering expenses payable by the Company.
    
 
   
<TABLE>
<CAPTION>
                                                                                     MARCH 31, 1996
                                                                    -------------------------------------------------
                                                                        ACTUAL          PRO FORMA       AS ADJUSTED
                                                                    ---------------  ---------------  ---------------
<S>                                                                 <C>              <C>              <C>
Current installments of long-term debt and obligations under
 capital leases...................................................  $       829,622  $       829,622  $       829,622
                                                                    ---------------  ---------------  ---------------
Long-term debt and obligations under capital leases, net of
 current installments.............................................  $       950,238  $       950,238  $       950,238
                                                                    ---------------  ---------------  ---------------
Stockholders' equity:
  Preferred Stock, $.01 par value per share, 6,000,000 shares
   authorized, 5,706,395 actual shares issued and outstanding; no
   pro forma or as adjusted shares issued or outstanding..........           57,064        --               --
  Class A Stock, $.01 par value, 513,093 actual shares authorized,
   issued and outstanding; no pro forma or as adjusted shares
   authorized or outstanding......................................            5,131        --               --
  Class B Stock, $.01 par value, 66,666 actual shares authorized,
   issued and outstanding; no pro forma or as adjusted shares
   authorized or outstanding......................................              667        --               --
  Common Stock, $.01 par value, 20,000,000 shares authorized;
   81,688 actual shares issued and outstanding; 6,564,048 pro
   forma and 9,364,048 as adjusted shares issued and
   outstanding(1).................................................              817           65,640           93,640
Additional paid-in capital........................................       22,761,905       22,759,944       45,567,944
Accumulated deficit...............................................      (14,123,924)     (14,123,924)     (14,123,924)
                                                                    ---------------  ---------------  ---------------
Total stockholders' equity........................................        8,701,660        8,701,660       31,537,660
                                                                    ---------------  ---------------  ---------------
Total capitalization..............................................  $    10,481,520  $    10,481,520  $    33,317,520
                                                                    ---------------  ---------------  ---------------
                                                                    ---------------  ---------------  ---------------
</TABLE>
    
 
- --------------------------
   
(1) Excludes  1,445,904 shares of Common Stock issuable upon exercise of options
    and warrants outstanding at March 31, 1996.
    
 
                                       15
<PAGE>
                                    DILUTION
 
    The net  tangible  book  value  of  the  Company  at  March  31,  1996,  was
approximately  $8.4 million,  or $1.28 per  share of Common  Stock, after giving
effect to the automatic  conversion of all outstanding  shares of the  Company's
Preferred  Stock, Class A  Stock and Class  B Stock into  shares of Common Stock
immediately prior to  the closing of  the Offering. After  giving effect to  the
sale  by the  Company of the  2,800,000 shares  of Common Stock  pursuant to the
Offering (at an  assumed initial public  offering price of  $9.00 per share  and
after  deducting  the  underwriting  discount  and  estimated  offering expenses
payable by the  Company), the pro  forma net  tangible book value  at such  date
would  have been approximately $31.2 million or $3.33 per share of Common Stock.
This represents an immediate  increase in net tangible  book value of $2.05  per
share  to existing stockholders and an immediate  dilution of $5.67 per share to
new investors purchasing shares in the Offering. The following table illustrates
the per share dilution to new investors:
 
<TABLE>
<S>                                                                    <C>        <C>
Assumed initial public offering price per share......................             $    9.00
  Net tangible book value per share at March 31, 1996(1).............  $    1.28
  Increase attributable to new investors.............................       2.05
                                                                       ---------
Pro forma net tangible book value per share after the Offering.......                  3.33
                                                                                  ---------
Dilution per share to new investors(2)...............................             $    5.67
                                                                                  ---------
                                                                                  ---------
</TABLE>
 
- --------------------------
(1) Net tangible book value  per share is determined  by dividing the  Company's
    tangible  net  worth (tangible  assets less  liabilities)  by the  number of
    shares of Common  Stock outstanding. Net  tangible book value  per share  of
    Common Stock excludes intangibles of $326,806, or $.05 per share.
 
(2) Dilution  per share is determined by  subtracting the pro forma net tangible
    book value per  share after  the Offering  from the  assumed initial  public
    offering price.
 
    Assuming  the Underwriters' over-allotment option  is exercised in full, pro
forma net tangible book value upon completion of the Offering would be $3.55 per
share, the immediate  increase in pro  forma net tangible  book value of  shares
owned  by  existing stockholders  would be  $2.27 per  share, and  the immediate
dilution to the new investors would be $5.45 per share.
 
    The following table sets forth, as of  March 31, 1996, the number of  shares
of  Common  Stock  (after  giving  effect to  the  automatic  conversion  of all
outstanding shares of the Company's Preferred  Stock, Class A Stock and Class  B
Stock  into  shares of  Common Stock  immediately  prior to  the closing  of the
Offering) previously purchased from the Company, the total consideration paid to
the Company and  the average price  per share  paid (i) by  existing holders  of
Common  Stock for  shares acquired during  the last  five years and  (ii) by the
investors purchasing shares of Common Stock in the Offering, assuming an initial
public offering price of $9.00 per share.
 
<TABLE>
<CAPTION>
                                                    SHARES PURCHASED(1)       TOTAL CONSIDERATION       AVERAGE
                                                   ----------------------  -------------------------     PRICE
                                                     NUMBER      PERCENT       AMOUNT       PERCENT    PER SHARE
                                                   -----------  ---------  --------------  ---------  -----------
<S>                                                <C>          <C>        <C>             <C>        <C>
Existing stockholders............................    6,564,048      70.1%  $   16,313,701      39.3%   $    2.49
New investors....................................    2,800,000      29.9%  $   25,200,000      60.7%   $    9.00
                                                   -----------  ---------  --------------  ---------
                                                     9,364,048     100.0%  $   41,513,701     100.0%
                                                   -----------  ---------  --------------  ---------
                                                   -----------  ---------  --------------  ---------
</TABLE>
 
- ------------------------
(1) Excludes 1,445,904 shares of Common Stock issuable upon exercise of  options
    and  warrants outstanding at March 31,  1996, at a weighted average exercise
    price of $2.16.
 
                                       16
<PAGE>
                            SELECTED FINANCIAL DATA
 
    The selected financial data of the Company  set forth below for each of  the
years ended December 31, 1993, 1994 and 1995, and at December 31, 1994 and 1995,
have  been derived from the audited financial statements of the Company included
elsewhere in this  Prospectus. Such  financial statements have  been audited  by
Arthur Andersen LLP, independent public accountants. The selected financial data
for  the years ended December 31, 1991 and  1992, and at December 31, 1991, 1992
and 1993, are derived from the audited financial statements of the Company which
are not  included  in the  Prospectus  and which  have  been audited  by  Arthur
Andersen  LLP, independent public  accountants. The selected  financial data set
forth below for each of the three-month  periods ended March 31, 1995 and  1996,
and  at March 31, 1996, have been derived from unaudited financial statements of
the Company included elsewhere in this Prospectus. In the opinion of  management
of  the Company, such  unaudited financial information  includes all adjustments
(consisting of  normal  recurring  accruals) considered  necessary  for  a  fair
presentation  of the Company's results of  operations for the periods then ended
and the Company's financial position as of such date. Operating results for  the
three-month  period ended March 31, 1996,  are not necessarily indicative of the
results for the entire year. This information should be read in conjunction with
"Management's Discussion  and Analysis  of Financial  Condition and  Results  of
Operations"  and the Company's  Financial Statements and  Notes thereto included
elsewhere in this Prospectus.
<TABLE>
<CAPTION>
                                                                                            THREE MONTHS ENDED
                                                  YEAR ENDED DECEMBER 31,                       MARCH 31,
                                   -----------------------------------------------------  ----------------------
                                     1991       1992       1993       1994       1995        1995        1996
                                   ---------  ---------  ---------  ---------  ---------  -----------  ---------
                                                       (IN THOUSANDS, EXCEPT PER SHARE DATA)
<S>                                <C>        <C>        <C>        <C>        <C>        <C>          <C>
STATEMENT OF OPERATIONS DATA:
Revenue..........................  $   2,145  $   4,813  $   9,348  $  14,531  $  19,758   $   4,619   $   5,908
Operating expenses:
  Direct cost of services and
   products......................      1,161      2,019      3,893      5,891      7,354       1,658       2,138
  Selling, general and
   administrative expenses.......      2,127      3,796      6,308      8,765      9,423       2,255       2,862
  Research and development.......        416        552      1,252      1,969      2,267         558         644
                                   ---------  ---------  ---------  ---------  ---------  -----------  ---------
    Total operating expenses.....      3,704      6,367     11,453     16,625     19,044       4,471       5,644
                                   ---------  ---------  ---------  ---------  ---------  -----------  ---------
  Income (loss) from
   operations....................     (1,559)    (1,554)    (2,105)    (2,094)       714         148         264
Other income (expense)...........         93         42        (63)      (203)      (181)        (56)        (33)
                                   ---------  ---------  ---------  ---------  ---------  -----------  ---------
Net income (loss)................  $  (1,466) $  (1,512) $  (2,168) $  (2,297) $     533   $      92   $     231
                                   ---------  ---------  ---------  ---------  ---------  -----------  ---------
                                   ---------  ---------  ---------  ---------  ---------  -----------  ---------
Pro forma net income (loss) per
 share(1)........................  $    (.61) $    (.37) $    (.41) $    (.38) $     .07   $     .01   $     .03
                                   ---------  ---------  ---------  ---------  ---------  -----------  ---------
                                   ---------  ---------  ---------  ---------  ---------  -----------  ---------
Shares used in computing pro
 forma net income (loss) per
 share(1)........................      2,396      4,093      5,233      6,104      7,296       6,588       7,523
                                   ---------  ---------  ---------  ---------  ---------  -----------  ---------
                                   ---------  ---------  ---------  ---------  ---------  -----------  ---------
 
<CAPTION>
 
                                                       DECEMBER 31,
                                   -----------------------------------------------------   MARCH 31,
                                     1991       1992       1993       1994       1995        1996
                                   ---------  ---------  ---------  ---------  ---------  -----------
                                                                  (IN THOUSANDS)
<S>                                <C>        <C>        <C>        <C>        <C>        <C>          <C>
BALANCE SHEET DATA:
Cash and cash equivalents........  $   2,140  $   3,002  $   1,193  $   1,823  $   3,125   $   1,301
Working capital..................      1,653      2,875      1,618      2,911      5,904       5,086
Total assets.....................      2,914      4,777      5,017      7,946     12,494      12,034
Long-term debt...................        189         63      1,009      2,063      1,666         950
Accumulated deficit..............     (8,909)   (10,421)   (12,590)   (14,887)   (14,355)    (14,124)
Total stockholders' equity.......      1,813      3,536      1,367      3,869      8,425       8,702
</TABLE>
 
- --------------------------
(1) Computed on the basis described in Note 2 to the Financial Statements.
 
                                       17
<PAGE>
          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS
 
    THIS  PROSPECTUS   CONTAINS,   IN  ADDITION   TO   HISTORICAL   INFORMATION,
FORWARD-LOOKING  STATEMENTS THAT INVOLVE RISKS  AND UNCERTAINTIES. THE COMPANY'S
ACTUAL RESULTS COULD DIFFER MATERIALLY.  FACTORS THAT COULD CAUSE OR  CONTRIBUTE
TO  SUCH DIFFERENCES INCLUDE, BUT ARE NOT  LIMITED TO, THOSE DISCUSSED BELOW, IN
"RISK FACTORS" AND "BUSINESS" AND ELSEWHERE IN THIS PROSPECTUS.
 
OVERVIEW
 
    UroCor provides  a  broad range  of  diagnostic services  for  the  clinical
management  of certain urological cancers and diseases. The Company's goal is to
complement its  diagnostic services  with therapeutic  products and  information
systems  in order to  become the leading disease  management company serving the
urology market. Through its  four business groups, UroDiagnostics,  UroSciences,
UroTherapeutics  and  Disease  Management Information  Systems,  the  Company is
developing an  integrated disease  management  approach to  serve the  needs  of
urologists  and managed  care organizations  for the  diagnostic, prognostic and
therapeutic care of patients throughout a disease cycle.
 
    The  Company  currently  derives  substantially  all  of  its  revenue  from
diagnostic  products and services that its  UroDiagnostics Group provides to the
urology  market  to  assist  in  the  diagnosis,  prognosis  and  management  of
urological  diseases. The Company  recognizes revenue when  products are sold or
services are rendered.  The Company typically  bills various third-party  payors
for its products and services, including governmental programs such as Medicare,
private insurance and managed care
plans,  as well as  individual patients. For  the year ended  December 31, 1995,
approximately 58%, 31%, 8% and 3%  of the Company's revenue was attributable  to
Medicare, private insurance and managed care, individual patients and physicians
and hospitals, respectively.
 
   
    The  Company  monitors the  collection  quality of  its  accounts receivable
through analytical review  of aging  categories by payor  group and  collections
performance  compared to historical trends. The Company assesses the adequacy of
its allowance for doubtful accounts on a periodic basis through specific reserve
percentages by payor aging categories,  as well as general reserve  percentages,
each  based  on past  experience and  adjusted as  changes in  conditions become
known. As part of this process, reserves in the underlying allowance account are
established  to  provide  for  possible  uncollectible  accounts.  The   Company
maintains what it believes to be an adequate level of the allowance for doubtful
accounts  through charges to  operations which are  included in selling, general
and administrative expenses.  The Company historically  has not experienced  any
material  write-off or collection  problems for which  adequate reserves had not
been established through its regular provision for doubtful accounts.
    
 
   
    During the three months  ended March 31, 1996,  the Company's allowance  for
doubtful  accounts declined from December 31, 1995, while the related balance of
accounts receivable increased  during this  period. In  addition, the  Company's
allowance  for doubtful accounts as a percentage of accounts receivable at March
31, 1996,  declined from  both March  31,  1995, and  December 31,  1995.  These
decreases  were due primarily to the write-off of certain delinquent receivables
for which reserves previously had been  allocated, as well as to an  improvement
in the aging of certain payor group categories.
    
 
    The  Company generally has  been able to  offset continuing downward pricing
pressures  from  Medicare  and  other  third-party  payors  by  introducing  new
diagnostic  products  and  enhancements  to  existing  products  as  well  as by
implementing selective  price increases.  The price  increases effected  by  the
Company  in 1993, 1994,  1995 and the  first three months  of 1996 accounted for
increased revenue in those periods of $162,000, $278,000, $284,000 and $116,000,
respectively. The net  result has been  an increase in  the average revenue  per
specimen  received  by the  Company  during 1993  through  1995. In  the future,
however, the Company expects to introduce additional products to its client base
which may reduce the average revenue per specimen.
 
    The Company's revenue has increased over  the past five years primarily  due
to  expansion of its physician client  base, increased market penetration of its
diagnostic products and services, introduction
 
                                       18
<PAGE>
   
of new products and  product enhancements and  selected price increases.  During
that period, the Company's revenue has increased generally at a faster rate than
total operating expenses, and, therefore, total operating expenses have declined
generally as a percentage of revenue. Direct expenses as a percentage of revenue
for  the first  three months  of 1996 totaled  36.2%, a  continuing decline from
prior annual periods. This trend  results from spreading fixed processing  costs
over higher sales volumes. The Company expects such trends generally to continue
primarily  due to further expansion of its client base and market penetration of
its products and  services, although it  does not expect  the decrease in  total
operating  expenses as a percentage  of revenue to continue  at the same rate as
over  the  past  three  years.  The  Company's  actual  performance  may  differ
materially  from the  Company's expectations.  The factors  that could  cause or
contribute to such differences include, but are not limited to, those  discussed
in "Risk Factors".
    
 
   
    In  connection with  the grant to  employees of options  to purchase 295,000
shares of Common Stock in December 1995  at a per share exercise price of  $1.75
and  considering the anticipated initial public offering price range of $8.00 to
$10.00 per share of the shares of Common Stock offered hereby and certain  other
events, the Company has estimated the adjusted fair value of Common Stock at the
date  of grant of the options to be  $3.25 per share. The Company will treat the
difference between the adjusted fair value and the actual exercise price of  the
options  as imputed compensation  expense. As a result,  the Company will record
non-cash charges to operations of approximately $33,500 per quarter, or $134,000
annually, in each  of the  years ending  December 31,  1996, 1997  and 1998  and
approximately $5,000 per quarter or $20,000 annually in each of the years ending
December  31, 1999  and 2000.  The quarterly  charge has  been reflected  in the
Company's results of operations for the three months ended March 31, 1996.
    
 
    No income  tax expense  was recorded  for 1995,  due to  utilization of  the
Company's  net operating loss  carryforwards. At December  31, 1995, the Company
had net operating loss carryforwards of approximately $9.6 million available  to
reduce future taxable income, subject to certain annual limitations.
 
RESULTS OF OPERATIONS
 
    The  following  table  sets  forth certain  operating  data  expressed  as a
percentage of revenue for each period indicated:
 
<TABLE>
<CAPTION>
                                                                                         THREE MONTHS ENDED
                                                        YEAR ENDED DECEMBER 31,              MARCH 31,
                                                   ----------------------------------  ----------------------
                                                      1993        1994        1995        1995        1996
                                                   ----------  ----------  ----------  ----------  ----------
<S>                                                <C>         <C>         <C>         <C>         <C>
Revenue..........................................      100.0%      100.0%      100.0%      100.0%      100.0%
Operating expenses:
  Direct cost of services and products...........       41.6        40.5        37.2        35.9        36.2
  Selling, general and administrative expenses...       67.5        60.3        47.7        48.8        48.4
  Research and development.......................       13.4        13.6        11.5        12.1        10.9
                                                       -----       -----       -----       -----       -----
    Total operating expenses.....................      122.5       114.4        96.4        96.8        95.5
                                                       -----       -----       -----       -----       -----
  Income (loss) from operations..................      (22.5)      (14.4)        3.6         3.2         4.5
Other income (expense)...........................       (0.7)       (1.4)       (0.9)       (1.2)       (0.6)
                                                       -----       -----       -----       -----       -----
Income (loss) before income taxes................      (23.2)      (15.8)        2.7         2.0         3.9
                                                       -----       -----       -----       -----       -----
Income taxes.....................................      --          --          --          --          --
                                                       -----       -----       -----       -----       -----
Net income (loss)................................      (23.2)%     (15.8)%       2.7%        2.0%        3.9%
                                                       -----       -----       -----       -----       -----
                                                       -----       -----       -----       -----       -----
</TABLE>
 
    THREE MONTHS ENDED MARCH 31, 1996 COMPARED TO THREE MONTHS ENDED MARCH 31,
1995
 
    REVENUE.  Revenue increased  27.9%, from approximately  $4.6 million in  the
first  three months  of 1995  to approximately $5.9  million in  the first three
months of 1996. This increase was due primarily to
 
                                       19
<PAGE>
a 44.3% increase in specimen volume, attributable primarily to expansion of  the
Company's physician client base, increased utilization of the Company's services
by  its clients and new product introductions and enhancements. The introduction
in February 1996 of the Company's new kidney stone product line and an  increase
in  serum based testing which have an average revenue per specimen of $40 to $70
each served to reduce the average revenue realized per specimen.
 
    DIRECT COST OF SERVICES AND PRODUCTS.  Direct cost of services and  products
increased  28.9%, from approximately  $1.7 million in the  first three months of
1995 to  approximately $2.1  million in  the first  three months  of 1996.  This
increase  was due principally  to higher personnel costs  of $207,000 and supply
and distribution costs of $217,000 resulting from increased specimen volume.  As
a  percentage of revenue, direct expenses increased to 36.2% for the first three
months of  1996  compared to  35.9%  for the  first  three months  of  1995  due
principally  to expenses  related to  the start-up  of the  Company's new kidney
stone line.
 
    SELLING,  GENERAL  AND  ADMINISTRATIVE  EXPENSES.    Selling,  general   and
administrative  expenses increased 27.0%, from approximately $2.3 million in the
first three months  of 1995  to approximately $2.9  million in  the first  three
months  of 1996.  This increase  was due  principally to  increases in personnel
costs of  $352,000 due  to  additional marketing  and  sales staff  and  billing
personnel,  as  well  as increases  in  promotional  expenses of  $66,000.  As a
percentage of revenue, selling, general  and administrative expenses were  48.4%
for  the first three months of 1996 compared to 48.8% for the first three months
of 1995.
 
    RESEARCH AND  DEVELOPMENT.    Research and  development  expenses  increased
15.3%,  from  approximately  $558,000  in  the first  three  months  of  1995 to
approximately $644,000 in the first three months of 1996. This increase was  due
principally  to  additional collaborative  research  projects for  the potential
development of new products and services.  As a percentage of revenue,  research
and  development expenses were 10.9% for the first three months of 1996 compared
to 12.1% for the first three months of 1995. Research and development costs  are
charged to operating expenses as incurred.
 
    OTHER INCOME (EXPENSE).  Interest income increased 48.9%, from approximately
$16,000 for the first three months of 1995 to approximately $23,000 in the first
three  months  of 1996.  Interest  expense decreased  20.4%,  from approximately
$71,000 in the first three months of 1995 to approximately $57,000 in the  first
three months of 1996, due to a decrease in average principal balances of capital
leases and the Company's bank credit facility.
 
    YEAR ENDED DECEMBER 31, 1995 COMPARED TO YEAR ENDED DECEMBER 31, 1994
 
    REVENUE.   Revenue increased 36.0%, from approximately $14.5 million in 1994
to approximately $19.8  million in 1995.  This increase was  due primarily to  a
19.3%  increase in specimen  volume combined with  increased average revenue per
specimen resulting from changes in product  mix and the effect of the  marketing
of  prostate  histology  sextant testing  services  for  the full  year  in 1995
compared to ten months in 1994.
 
    DIRECT COST OF SERVICES AND PRODUCTS.  Direct cost of services and  products
increased  24.8%, from approximately $5.9 million  in 1994 to approximately $7.4
million in 1995. This increase was  due principally to higher personnel,  supply
and distribution costs resulting from increased specimen volume. As a percentage
of revenue, direct expenses were 37.2% for 1995 compared to 40.5% in 1994.
 
    SELLING,   GENERAL  AND  ADMINISTRATIVE  EXPENSES.    Selling,  general  and
administrative expenses increased 7.5%, from approximately $8.8 million in  1994
to  approximately $9.4  million in  1995. This  increase was  due principally to
increased costs of sales force personnel  and marketing staff for the full  year
in 1995, as the managed care sales group and several other positions were filled
in  mid 1994. Promotional expenses related to the managed care sales effort also
increased  due  to  activity  for  the  full  year  in  1995  compared  to   the
approximately  six months  following the  deployment of  the managed  care sales
force  in  mid  1994.  As  a   percentage  of  revenue,  selling,  general   and
administrative expenses were 47.7% for 1995 compared to 60.3% in 1994.
 
                                       20
<PAGE>
    RESEARCH  AND  DEVELOPMENT.   Research  and  development  expenses increased
15.1%, from approximately $2.0 million in 1994 to approximately $2.3 million  in
1995.  This increase  was due  principally to  additional collaborative research
projects for the development of potential new products and services, as well  as
internal  research  laboratory  personnel  costs. As  a  percentage  of revenue,
research and development expenses were 11.5% for 1995 compared to 13.6% in 1994.
 
    OTHER INCOME (EXPENSE).  Interest income increased 4.8%, from  approximately
$104,000  in 1994 to approximately $109,000  in 1995. Interest expense decreased
5.5%, from approximately $307,000 in 1994 to approximately $290,000 in 1995, due
to a decrease in average principal balances of capital leases and the  Company's
bank credit facility during 1995.
 
    YEAR ENDED DECEMBER 31, 1994 COMPARED TO YEAR ENDED DECEMBER 31, 1993
 
    REVENUE.   Revenue increased 55.4%, from  approximately $9.3 million in 1993
to approximately $14.5  million in 1994.  This increase was  due primarily to  a
42.2% increase in specimen volume, as well as an increase in the average revenue
per  specimen principally resulting from  the introduction of prostate histology
sextant testing in March 1994.
 
    DIRECT COST OF SERVICES AND PRODUCTS.  Direct cost of services and  products
increased  51.3%, from approximately $3.9 million  in 1993 to approximately $5.9
million in  1994. This  increase  was due  principally to  increased  personnel,
supplies  and logistics costs resulting from higher specimen volumes, as well as
changes in product mix due to the introduction of the prostate histology sextant
testing service. As a percentage of revenue, direct expenses were 40.5% for 1994
compared to 41.6% in 1993.
 
    SELLING,  GENERAL  AND  ADMINISTRATIVE  EXPENSES.    Selling,  general   and
administrative expenses increased 38.9%, from approximately $6.3 million in 1993
to  approximately $8.8 million in 1994. This  increase was due to an increase of
32 additional personnel  in 1994  over 1993,  principally a  managed care  sales
group,  deployed in  mid 1994, as  well as increased  sales support, information
services and billing personnel. In addition, marketing and promotional  expenses
increased related to the managed care sales group, new diagnostic services and a
higher level of sales activity. As a percentage of revenue, selling, general and
administrative expenses were 60.3% for 1994 compared to 67.5% in 1993.
 
    RESEARCH  AND  DEVELOPMENT.   Research  and  development  expenses increased
57.3%, from approximately $1.3 million in 1993 to approximately $2.0 million  in
1994.  This increase  was due principally  to an increase  in research personnel
from 14 in 1993 to 21 in 1994, resulting in higher personnel and supplies costs,
as well  as an  increase  in collaborative  research  project fundings  for  the
development  of potential new products and services. As a percentage of revenue,
research and development expenses were 13.6% for 1994 compared to 13.4% in 1993.
 
    OTHER  INCOME   (EXPENSE).     Interest   income  increased   130.3%,   from
approximately  $45,000 in 1993 to approximately  $104,000 in 1994, due to higher
average balances of  cash and  cash equivalents during  1994. Interest  expenses
increased  183.0%, from approximately $109,000 in 1993 to approximately $307,000
in 1994, due to an increase in average principal balances of capital leases  and
the Company's bank credit facility during 1994.
 
QUARTERLY RESULTS OF OPERATIONS
 
    The  following tables  present the Company's  results of  operations for the
last 13 calendar quarters  and the percentage relationship  of certain items  to
revenue  for such quarters. This data is  unaudited and includes, in the opinion
of  the  Company's  management,  all  adjustments  (consisting  only  of  normal
recurring  adjustments) necessary to present fairly  the data in accordance with
generally  accepted  accounting  principles.  Such  quarterly  results  are  not
necessarily indicative of future results of operations.
 
    The  Company's quarterly operating results are affected by a wide variety of
factors, many of which are outside the Company's control, that could  materially
and  adversely  affect revenue,  operating  expenses and  income.  These factors
include the  volume  and  timing  of  specimens  received,  competitive  pricing
pressures,  availability and cost of diagnostic  supplies, changes in the mix of
products sold,
 
                                       21
<PAGE>
seasonality related to the timing of patient visits to the urologist's office as
affected by weather and insurance deductible status, the timing and costs of new
product  and  technology  introductions  by  the  Company  or  its  competitors,
retention and expansion of the Company's sales force and timing of payments from
Medicare and other third-party payors.
<TABLE>
<CAPTION>
                                                          DOLLARS IN THOUSANDS
                               ---------------------------------------------------------------------------
                                              1993                                   1994
                               -----------------------------------   -------------------------------------
                                 Q1      Q2        Q3        Q4        Q1        Q2        Q3        Q4
                               ------  -------   -------   -------   -------   -------   -------   -------
<S>                            <C>     <C>       <C>       <C>       <C>       <C>       <C>       <C>
Revenue......................  $1,804   $2,283    $2,252    $3,009    $2,786    $3,487    $3,741    $4,517
                               ------  -------   -------   -------   -------   -------   -------   -------
Operating expenses:
  Direct costs of services
   and products..............     844    1,033       959     1,057     1,193     1,346     1,559     1,793
  Selling, general and
   administrative expenses...   1,471    1,504     1,653     1,680     1,873     2,041     2,383     2,468
  Research and development...     184      296       378       394       404       457       517       591
                               ------  -------   -------   -------   -------   -------   -------   -------
  Income (loss) from
   operations................    (695)    (550)     (738)     (121)     (684)     (357)     (718)     (335)
Other income (expense).......      13        6       (28)      (54)      (66)      (37)      (41)      (59)
                               ------  -------   -------   -------   -------   -------   -------   -------
Income (loss) before income
 taxes.......................    (682)    (544)     (766)     (176)     (750)     (394)     (759)     (394)
Income taxes (benefit).......    --      --        --        --        --        --        --        --
                               ------  -------   -------   -------   -------   -------   -------   -------
Net income (loss)............  $ (682)  $ (544)   $ (766)   $ (176)   $ (750)   $ (394)   $ (759)   $ (394)
                               ------  -------   -------   -------   -------   -------   -------   -------
                               ------  -------   -------   -------   -------   -------   -------   -------
 
<CAPTION>
 
                                               1995                     1996
                               -------------------------------------   -------
                                 Q1        Q2        Q3        Q4        Q1
                               -------   -------   -------   -------   -------
<S>                            <C>       <C>       <C>       <C>       <C>
Revenue......................   $4,619    $4,824    $4,784    $5,531    $5,908
                               -------   -------   -------   -------   -------
Operating expenses:
  Direct costs of services
   and products..............    1,658     1,749     1,849     2,098     2,138
  Selling, general and
   administrative expenses...    2,255     2,342     2,276     2,550     2,862
  Research and development...      558       540       540       629       644
                               -------   -------   -------   -------   -------
  Income (loss) from
   operations................      148       193       119       254       264
Other income (expense).......      (56)      (63)      (40)      (22)      (33)
                               -------   -------   -------   -------   -------
Income (loss) before income
 taxes.......................       92       130        79       232       231
Income taxes (benefit).......    --        --        --        --        --
                               -------   -------   -------   -------   -------
Net income (loss)............    $  92     $ 130     $  79     $ 232     $ 231
                               -------   -------   -------   -------   -------
                               -------   -------   -------   -------   -------
</TABLE>
<TABLE>
<CAPTION>
                                                       AS A PERCENTAGE OF REVENUE
                               ---------------------------------------------------------------------------
                                              1993                                   1994
                               -----------------------------------   -------------------------------------
                                 Q1      Q2        Q3        Q4        Q1        Q2        Q3        Q4
                               ------  -------   -------   -------   -------   -------   -------   -------
<S>                            <C>     <C>       <C>       <C>       <C>       <C>       <C>       <C>
Revenue......................   100.0%   100.0%    100.0%    100.0%    100.0%    100.0%    100.0%    100.0%
Operating expenses:
  Direct costs of services
   and products..............    46.8     45.3      42.6      35.1      42.8      38.6      41.7      39.7
  Selling, general and
   administrative expenses...    81.5     65.8      73.4      55.8      67.2      58.5      63.7      54.6
  Research and development...    10.2     13.0      16.8      13.1      14.5      13.1      13.8      13.1
                               ------  -------   -------   -------   -------   -------   -------   -------
  Income (loss) from
   operations................   (38.5)   (24.1)    (32.8)     (4.0)    (24.5)    (10.2)    (19.2)     (7.4)
Other income (expense).......     0.7      0.3      (1.2)     (1.8)     (2.4)     (1.1)     (1.1)     (1.3)
                               ------  -------   -------   -------   -------   -------   -------   -------
Income (loss) before income
 taxes.......................   (37.8)   (23.8)    (34.0)     (5.8)    (26.9)    (11.3)    (20.3)     (8.7)
Income taxes (benefit).......    --      --        --        --        --        --        --        --
                               ------  -------   -------   -------   -------   -------   -------   -------
Net income (loss)............   (37.8)%   (23.8)%   (34.0)%    (5.8)%   (26.9)%   (11.3)%   (20.3)%    (8.7)%
                               ------  -------   -------   -------   -------   -------   -------   -------
                               ------  -------   -------   -------   -------   -------   -------   -------
 
<CAPTION>
 
                                               1995                     1996
                               -------------------------------------   -------
                                 Q1        Q2        Q3        Q4        Q1
                               -------   -------   -------   -------   -------
<S>                            <C>       <C>       <C>       <C>       <C>
Revenue......................    100.0%    100.0%    100.0%    100.0%    100.0%
Operating expenses:
  Direct costs of services
   and products..............     35.9      36.3      38.7      37.9      36.2
  Selling, general and
   administrative expenses...     48.8      48.5      47.6      46.1      48.4
  Research and development...     12.1      11.2      11.3      11.4      10.9
                               -------   -------   -------   -------   -------
  Income (loss) from
   operations................      3.2       4.0       2.4       4.6       4.5
Other income (expense).......     (1.2)     (1.3)     (0.8)     (0.4)     (0.6)
                               -------   -------   -------   -------   -------
Income (loss) before income
 taxes.......................      2.0       2.7       1.6       4.2       3.9
Income taxes (benefit).......    --        --        --        --        --
                               -------   -------   -------   -------   -------
Net income (loss)............      2.0%      2.7%      1.6%      4.2%      3.9%
                               -------   -------   -------   -------   -------
                               -------   -------   -------   -------   -------
</TABLE>
 
LIQUIDITY AND CAPITAL RESOURCES
 
   
    Since  the Company's  reorganization in 1991,  the Company  has financed its
operations primarily through  the issuance  of equity  securities, resulting  in
aggregate proceeds of approximately $16.3 million. The Company's working capital
needs have increased during that period and are expected to continue to increase
as  the  Company  expands its  operations.  Since 1994,  the  Company's Medicare
intermediary and certain other third-party  payors have increased the amount  of
time  between  their receipt  of  claims for  reimbursement  and payment  to the
Company. At  March 31,  1996, the  Company's  average number  of days  sales  in
receivables  was  approximately 74  compared to  49 at  December 31,  1994. Such
delays in  payments to  the  Company have  resulted  in the  Company's  accounts
receivable  increasing  at a  rate greater  than the  revenue growth  rate. Such
delays also have affected the Company's cash flow from operations. As a  result,
the  Company has used its  bank credit facility from  time to time to supplement
its cash flows. The Company also  has used capital lease financing  arrangements
to  fund the acquisition of certain equipment. The arrangements have allowed the
Company to be reimbursed for the equipment cost and generally have provided  for
repayment of such amounts, with interest, over a four-year period.
    
 
    As  of  March  31,  1996,  the Company  had  cash  and  cash  equivalents of
approximately $1.3 million and working capital of $5.1 million. Net cash used in
operating activities  was  approximately $2.3  million,  $2.4 million  and  $0.5
million  in 1993,  1994 and  1995, respectively  and approximately  $0.5 million
 
                                       22
<PAGE>
for the  three months  ended March  31, 1996.  The net  cash used  in  operating
activities  in  1995 was  primarily the  result  of a  $1.9 million  increase in
accounts receivable, offset in part by net income of approximately $0.5 million,
depreciation and amortization of approximately  $0.9 million and an increase  in
accrued  compensation  of  approximately  $0.2 million.  The  net  cash  used in
operating activities for the  three months ended March  31, 1996, was  primarily
the  result of increases in accounts receivable and other current assets of $0.6
million and  $0.4  million,  respectively,  offset in  part  by  net  income  of
approximately $0.2 million and by depreciation and amortization and stock option
compensation  expense totaling approximately $0.3  million. The Company believes
that it could maintain its current  level of operations using its existing  cash
resources, bank credit facility, equipment leases and cash flow from operations.
 
   
    Net cash used in investing activities was approximately $1.2 million in 1995
and  consisted primarily of capital expenditures  of $1.4 million for laboratory
and computer equipment and office equipment and improvements and a $0.5  million
milestone  payment  under the  distribution rights  agreement for  the Company's
proposed  BCG  therapeutic  product,  offset  by  proceeds  from  capital  lease
arrangements of $0.8 million. Net cash provided by financing activities was $3.0
million for 1995 and consisted primarily of net proceeds from stock issuances of
$4.0  million, offset  in part  by principal  payments under  capital leases and
other indebtedness of $0.7 million and repayments of $0.3 million under the bank
credit facility. For the  three months ended  March 31, 1996,  net cash used  in
investing  activities was  approximately $0.5  million, consisting  primarily of
capital expenditures of approximately $0.5  million for laboratory and  computer
equipment  and office equipment,  and net cash used  in financing activities was
approximately $0.9 million, primarily due  to reduction of borrowings under  the
Company's bank credit facility of $0.7 million.
    
 
    The  Company's bank credit facility permits the Company to borrow up to $3.0
million and is secured by accounts receivable  and a lien on all other  tangible
assets,  which does  not include equipment  leased by the  Company under capital
leases. Funds borrowed under the credit facility bear interest monthly at a  per
annum  interest rate of prime plus 1.5% (9.75% as of March 31, 1996). The credit
facility expires in February 1997, and as of May 10, 1996, there were no amounts
borrowed under this credit facility.
 
    The Company's  capital expenditures  were approximately  $1.6 million,  $1.0
million,  $1.4 million and $0.5 million in 1993, 1994, 1995 and the three months
ended March  31,  1996, respectively.  While  future capital  expenditures  will
depend  upon a number  of factors, including the  progress of certain technology
acquisitions, the level of  such expenditures is expected  to increase over  the
historical  level  of  such expenditures.  The  Company intends  to  finance the
majority of these capital expenditures through lease financing arrangements  and
with  a portion of  the proceeds of  the Offering. The  Company historically has
been able to secure such lease financing on favorable terms. In April 1996,  the
Company  secured an increase in one of its existing capital leases of up to $1.5
million for future  capital expenditures  made through  March 1997.  At May  10,
1996,   the  Company  has  certain  cancellable  commitments  for  computer  and
laboratory information systems totalling approximately $600,000.
 
    In December 1994, the Company  obtained distribution rights to its  proposed
BCG  therapeutic product currently under FDA  review for marketing approval. The
total cost of the distribution  rights is $3.0 million,  which is being paid  in
installments  based on achievement of certain  milestones. An initial payment of
$750,000 was made  in December 1994,  and a second  installment of $500,000  was
paid  in 1995 after the product was submitted  for FDA review in April 1995. The
Company is obligated  to pay an  additional milestone payment  of $1.75  million
when or if the product completes the FDA approval process.
 
    The  Company anticipates  that its  operations and  growth strategy  will be
financed through the net  proceeds from the Offering,  operating cash flow,  its
existing  bank credit facility  and equipment leases.  The Company believes that
these sources  of funds  will be  sufficient to  satisfy the  Company's  capital
requirements  for at least 24 months.  There may be circumstances, however, that
would accelerate  the Company's  use  of proceeds  from  the Offering.  If  this
occurs,  the Company  may, from time  to time, incur  additional indebtedness or
issue, in public or private transactions, equity or debt securities. The Company
currently has no arrangements, however,  for additional financing and there  can
be no assurance that the Company will be able to attain requisite financing when
needed on acceptable terms.
 
                                       23
<PAGE>
                                    BUSINESS
 
OVERVIEW
 
    UroCor  provides  a  broad range  of  diagnostic services  for  the clinical
management of certain urological cancers and diseases. The Company's goal is  to
complement  its diagnostic  services with  therapeutic products  and information
systems in order to  become the leading disease  management company serving  the
urology  market. Through its four  business groups, UroDiagnostics, UroSciences,
UroTherapeutics and  Disease  Management  Information Systems,  the  Company  is
developing  an  integrated disease  management approach  to  serve the  needs of
urologists and managed  care organizations  for the  diagnostic, prognostic  and
therapeutic   care  of  patients  throughout  a  disease  cycle.  The  Company's
UroDiagnostics Group  provides  diagnostic  services to  over  1,400  urologists
nationwide.  This  group provides  comprehensive  diagnostic services  to detect
major urological diseases, predict prognosis of the patient's condition, monitor
the patient's therapy and  identify recurrence of  the disease. The  UroSciences
Group's  goal  is to  become  a leader  in  the development  and  application of
advanced  diagnostic  technologies  and   information  resources  for   managing
urological diseases. The UroTherapeutics Group was established to acquire rights
to  sell through  the Company's  existing sales  force urological pharmaceutical
products for use  in the  urologist's office. The  Company's Disease  Management
Information  Systems group  is designed to  provide urologists  and managed care
organizations with  access  to  the  Company's  proprietary  urological  disease
database,  disease management models and practice management guidelines in order
to improve the diagnosis and treatment of patients.
 
UROLOGY MARKET
 
    The urology market differs from  most other medical care markets,  primarily
because  of  the  distinctive  characteristics of  urological  diseases  and the
multiple roles  of the  urologist. The  urologist often  serves as  the  primary
diagnostician,  oncologist  and surgeon  for the  treatment of  prostate cancer,
bladder cancer,  kidney stone  disease and  other complex  urological  diseases.
Patients  with prostate  or bladder cancer  generally require  management of the
disease by the urologist  throughout a disease cycle  ranging from three to  ten
years.  The urologist requires sophisticated diagnostic and information services
throughout that period. Despite the urologist's need for comprehensive services,
currently, diagnostic services, therapeutic  products and information  resources
are  provided  primarily by  local hospitals,  pathology laboratories  and other
companies that do not focus exclusively on urological disease.
 
    UroCor serves the segment of the United States urology market consisting  of
over 7,500 office-based urologists, including those affiliated with managed care
organizations.  These urologists diagnose  and treat patients  who generally are
referred to  them by  another  physician for  prostate cancer,  bladder  cancer,
kidney  stone  disease and  other  complex urological  diseases.  An independent
survey estimated  that in  1993 there  were almost  15 million  urology  patient
visits  in  the  United  States.  The  American  Cancer  Society  estimates that
approximately 300,000  new cases  of prostate  cancer and  52,000 new  cases  of
bladder  cancer will be diagnosed in 1996,  resulting in medical costs in excess
of $5.0 billion.
 
STRATEGY
 
    To achieve its goal  of becoming the leading  disease management company  in
the  urology  market, UroCor  is pursuing  a  strategy directed  at establishing
itself as  a single  resource  for the  treatment  of prostate  cancer,  bladder
cancer,  kidney stone disease  and other complex diseases.  The Company plans to
expand its current diagnostic products and services and to offer therapeutic and
information systems products to serve the  needs of urologists and managed  care
organizations,  from initial indication of  selected urological diseases through
ultimate disease outcome. Through its UroDiagnostics and UroSciences Groups, the
Company currently  offers comprehensive  diagnostic, prognostic  and  monitoring
services  and  information.  The  Company  also  plans  to  offer,  through  its
UroTherapeutics Group and
 
                                       24
<PAGE>
Disease  Management  Information  Systems,  new  technologies  and  products  to
complement  its  diagnostic  services  business  and  to  provide  an integrated
resource for the management of urological  disease. The Company is pursuing  the
following strategies to achieve its objective:
 
    - INCREASE  MARKET PENETRATION OF OFFICE-BASED UROLOGISTS. Approximately 19%
      of the  more  than 7,500  office-based  urologists in  the  United  States
      currently  use  one or  more of  the  UroDiagnostic Group's  services. The
      Company has established a direct sales force, including specialists  whose
      focus is marketing to managed care organizations, dedicated solely to this
      market. Through the use of its specialized sales force and its emphasis on
      managed  care organizations, the Company expects to increase the number of
      urologists using its services and the  number of their patients served  by
      the Company.
 
    - EXPAND  USE OF  EXISTING PRODUCT  LINES. The  Company's UroDiagnostics and
      UroSciences Groups combine  their efforts to  improve the performance  of,
      education  relating  to  and clinical  evidence  supporting  the Company's
      existing diagnostic products and services.  In 1995, approximately 41%  of
      the  Company's  urologist  clients used  more  than one  of  the Company's
      services. The Company believes that it can increase the number of products
      used by each urologist through continued efforts by its specialized  sales
      force  to educate the  market on the  benefits of all  of UroCor's product
      lines.
 
    - EXPAND TOTAL  PRODUCT  OFFERING.  Through the  UroDiagnostics  Group,  the
      Company's direct sales force currently markets a broad range of diagnostic
      products  and  services  to  urologists  and  managed  care organizations.
      Through  its  UroSciences   Group,  UroTherapeutics   Group  and   Disease
      Management Information Systems, the Company intends to increase the number
      of  products and  services offered  to its  existing urologist  clients by
      developing, licensing  or acquiring  technologies and  products that  will
      expand  the total mix of products and services offered, including products
      that address additional urological diseases.
 
    - STRENGTHEN MARKET  TIES  WITH  ON-LINE  SYSTEMS.  The  Disease  Management
      Information  Systems group intends to link  the Company to its client base
      through a dedicated customized wide area network. The initial applications
      developed for  the  network are  intended  to improve  the  efficiency  of
      specimen  and patient information collection by  the urologists as well as
      the initial  reporting of  diagnostic results  and consultation  with  the
      Company's   pathologists.   UroCor  intends   to  strengthen   its  client
      relationships by developing and providing on-line disease pathway  models,
      decision support systems and patient outcome tracking ability.
 
DISEASE MANAGEMENT BUSINESS
 
    URODIAGNOSTICS GROUP -- PRODUCTS
 
    The  UroDiagnostics  Group  provides  diagnostic  services  for office-based
urologists. The  Company believes  that the  UroDiagnostics Group  provides  the
foundation  for  the development  of an  integrated disease  management company.
Unlike its competitors, who  generally offer varied products  and services to  a
broader  health  care market,  the  UroDiagnostics Group  provides comprehensive
diagnostic services to  detect and diagnose  certain major urological  diseases,
make  a prognosis of the patient's  condition, monitor the patient's therapy and
identify recurrence of the disease.
 
    The Company  emphasizes  customer  service, including  the  provision  of  a
comprehensive  detailed report  to the  referring physician  after completion of
each specimen analysis. The  Company's relations with  its clients are  enhanced
through  its regional customer service  representatives, who are responsible for
inquiries made by  referring physicians  and provide support  for the  Company's
sales force.
 
    The  Company's  sales of  diagnostic services  have grown  rapidly. UroCor's
client base increased from 380 at the end  of 1991 to 1,320 at the end of  1995.
The  UroDiagnostics Group generated  revenues of approximately  $19.6 million in
1995,  constituting   approximately   99%   of   the   Company's   revenue   for
 
                                       25
<PAGE>
1995.  The  Company attributes  its growth  to its  concentration on  building a
relationship  with  urologists  while  developing  and  servicing  an  important
marketing  and education channel to urologists which the Company believes it can
leverage through the delivery of additional products and services.
 
    The following chart sets forth the principal products and services currently
offered through the UroDiagnostics Group.
<TABLE>
  <S>                                <C>
                           UROLOGICAL DIAGNOSTIC SERVICES
 
<CAPTION>
 
                PRODUCT                               APPLICATION
  --------------------------------------------------------------------------------
  <S>                                <C>
   PROSTATE CANCER
    SERUM BASED
      PSA and PSA velocity           Detects and monitors disease
      Free/Total PSA*                Increases specificity of detection
    TISSUE BASED
      Sextant biopsy                 Increases diagnostic accuracy
      UroScore-Registered Trademark- Improves clinical staging and treatment
                                     selection
 
   BLADDER CANCER
    CELLULAR BASED
      Cellular pathology and DNA
   analysis                          Detects and diagnoses disease
      Antibody markers               Detects and diagnoses disease
    SOLUBLE ANTIGEN
      Antibody markers               Monitors disease
    TISSUE BASED
      Pathological examination       Provides definitive diagnosis and prognosis
      Antibody markers               Provides definitive diagnosis and prognosis
 
   MICROHEMATURIA
      Urine protein chemistry
   analysis                          Differentiates between upper or lower tract
                                     disease
      Microscopic examination        Differentiates between upper or lower tract
                                     disease
 
   KIDNEY STONES
      Stone analysis                 Determines stone structure and chemistry
      Serum chemistry                Identifies underlying disease
      24-hour soluble urine chemistry Assesses recurrence risk
   ------------------------
   *Not currently reimbursed by third-party payors, including Medicare.
</TABLE>
 
    PROSTATE CANCER PRODUCTS.  The  American Cancer Society estimates that  over
300,000  cases of  prostate cancer  will be  diagnosed in  1996, compared  to an
estimated 244,000 cases diagnosed in 1995. It also is estimated that one in five
males will suffer from the disease.  The Company believes that this increase  in
incidence  is due to  a variety of  factors, including the  increase in the life
expectancy of  the general  population and  improved prostate  cancer  detection
capabilities.  According to  the American Cancer  Society, the  medical costs of
prostate cancer in  the United  States are  estimated to  be approximately  $5.0
billion in 1996.
 
    Management  of  prostate cancer  requires the  urologist to  screen, detect,
diagnose, prognose and treat the patient and monitor progression of the disease.
UroCor has developed and markets products
 
                                       26
<PAGE>
and services that assist the urologist in  each of the diagnostic steps in  this
disease  cycle. UroCor's  PSA product  is used in  screening for  the disease to
improve the urologist's ability to  identify true positive cancer patients.  The
Company's  Free/Total PSA product is used for the same purpose and increases the
urologist's ability  to  detect  the  disease. UroCor  currently  is  using  the
Free/Total  PSA product on a  limited basis to build  a clinical case validating
its advantages prior to seeking reimbursement approval from third-party  payors.
The current preferred method for detecting the disease after the screening stage
is  the prostate biopsy. UroCor was an early proponent of the use of the sextant
biopsy technique  which has  been demonstrated  to increase  the possibility  of
finding small, localized tumor tissue in the prostate.
 
    After  screening  and  detection  of  prostate  cancer,  the  urologist must
accurately "stage" or classify the disease  to determine whether the cancer  has
spread  beyond the prostate gland. UroCor  developed its UroScore test to assist
the urologist in this step, which provides improvement in the ability to predict
whether the disease has progressed beyond the prostate gland. After staging  the
disease,  the urologist  determines whether to  treat the  disease with surgery,
radiation or  drug  therapy  or  simply to  monitor  its  progress.  UroCor  has
developed  expertise  in  advising  the  urologist  on  the  probability  that a
patient's cancer will progress. This information is enhanced by the Company's 11
pathologists who interpret  the prognostic information  in conjunction with  the
patient's  diagnostic pathology report. After reaching a treatment decision, the
urologist can monitor the patient for  evidence of recurrence or eradication  of
the disease by using the Company's PSA products.
 
    BLADDER  CANCER PRODUCTS.   According to  the American  Cancer Society, over
50,000 cases of bladder cancer  are estimated to be  diagnosed each year in  the
United  States.  Some  of  the  difficulties that  the  urologist  faces  in the
diagnosis and management of bladder cancer include detecting tumors at an  early
stage  and  assessing  the  aggressiveness of  tumors.  UroCor's  bladder cancer
products provide the urologist with analysis and information capabilities in all
significant aspects of the diagnosis and management of the disease. In addition,
unlike competing  products, UroCor's  bladder cellular  analysis incorporates  a
multi-modality  approach  that the  Company believes  provides, compared  to its
competitors, increased  levels of  analysis  and corresponding  improvements  in
specificity  and sensitivity of test results.  The Company's full bladder cancer
detection  program   combines   the  information   from   separate   microscopic
examinations of a patient's specimen using two different techniques, an analysis
of  the DNA in  cell nuclei, and the  use of one or  more specific biomarkers to
assist the pathologist test for the presence of cancer.
 
    MICROHEMATURIA PRODUCTS.  Microhematuria, or  the presence of small  amounts
of  blood in the urine, is one of the  conditions that may relate to a number of
urinary tract  diseases  and infections.  The  initial challenge  faced  by  the
urologist  in  diagnosing  the  underlying cause  of  the  microhematuria  is to
identify the source  of the  bleeding. UroCor's  microhematuria diagnostic  test
combines a microscopic examination of urine sediment by expert pathologists with
a  urine protein chemistry analysis to provide the urologist with information on
the probable  location of  the bleeding  and the  potential underlying  disease.
Because microhematuria may be one of the indications of bladder or other urinary
tract  cancer,  the  Company's comprehensive  diagnostic  analysis  provides the
urologist a  resource to  investigate and  confirm potential  causes of  bladder
cancer.
 
    KIDNEY STONE PRODUCTS.  Kidney stone disease typically requires physical and
chemical  analysis of the stone, and, in many cases, analysis of patients' urine
and serum specimens to assess the risk of disease recurrence. Traditionally, the
urologist was  required  to send  each  of the  kidney  stone, urine  and  serum
specimen  to different testing service providers. UroCor's kidney stone products
offer a complete program in which the urologist delivers all specimens to UroCor
and receives an integrated analysis and report.
 
                                       27
<PAGE>
    URODIAGNOSTICS GROUP -- SALES AND MARKETING
 
    The Company markets  its diagnostic services  to the segment  of the  market
consisting of more than 7,500 office-based urologists in the United States, many
of  whom are affiliated with one or  more managed care organizations. UroCor has
developed a sales  force dedicated and  trained to market  solely to  urologists
including  representatives  specializing  solely in  marketing  to  managed care
organizations.
 
    The Company's market  penetration has  advanced rapidly over  the past  five
years.  The  following chart  sets  forth historical  information  regarding the
urologist clients served by the Company and related information.
 
<TABLE>
<CAPTION>
                                                                              AT DECEMBER 31,
                                                         ---------------------------------------------------------
                                                           1991       1992       1993        1994         1995
                                                         ---------  ---------  ---------  -----------  -----------
<S>                                                      <C>        <C>        <C>        <C>          <C>
Number of urologist clients(1).........................        380        620      1,030        1,250        1,320
Number of specimens analyzed...........................     18,300     40,500     76,500      108,900      130,000
Average annual revenue per urologist...................  $   7,200  $   9,600  $  11,200  $    12,600  $    15,200
Percentage of multiple product users among total
 urologist clients.....................................         13%        19%        24%          34%          41%
Number of managed care contracts.......................         --          2          4           30           67
Total sales force......................................         11         28         31           35           35
</TABLE>
 
- --------------------------
(1) Represents the  number of  urologists  who used  the Company's  services  in
    December of each of the years indicated.
 
    The  Company intends to continue its penetration of the market by continuing
its efforts  to  expand its  client  base and  to  add additional  products  and
services to its product line for existing and future customers. The Company also
intends  to use its wide  area network link with its  client base to enhance the
regular two-way  communication between  the Company  and its  customers.  UroCor
believes that the wide area network will facilitate the introduction and support
of  new products and services  and increase the number  of products and services
used by existing clients.
 
    Commencing in  1994, the  Company began  focusing on  securing managed  care
contracts to permit UroCor to provide products and services to patients enrolled
in  these  health  care  organizations.  The  Company  currently  has  over  600
urologists  in  its   client  base   whose  patients  are   enrolled  in   these
organizations.  The Company intends  to increase its  penetration of the managed
care market by developing  products and services  specifically designed to  meet
the  cost control, quality  assurance and other  requirements imposed by managed
care organizations.
 
    In addition to its focus on the individual urologist client and managed care
organizations, the Company is concentrating its marketing efforts on identifying
and marketing products to the growing number of group practices and  independent
practice associations forming to specialize in urology.
 
    UROSCIENCES GROUP
 
    The  goal of the UroSciences Group is  to become a leader in the development
and  application  of  diagnostic  technologies  and  information  resources  for
managing  urological diseases. The UroSciences Group combines access to external
resources at  academic  centers  and  research  institutes  with  the  Company's
internal  development  and assessment  capabilities  to develop  and  launch new
technologies and products. The UroSciences Group's internal capabilities combine
the  expertise  of  five  different  laboratories  currently  staffed  with   23
scientists  and experienced  technical personnel. Participants  in the Company's
collaborative programs  include  M.D.  Anderson  Cancer  Center,  Johns  Hopkins
Medical Institutions, Baylor College of Medicine, Michigan Prostate Institute at
the University of Michigan, Michigan Cancer Foundation, Eastern Virginia Medical
School,  University of Texas  Southwestern Medical Center  and the University of
Washington.
 
    The UroSciences  Group has  developed a  database of  thousands of  cellular
tissue  and serum specimens of patients  related to the diagnosis, prognosis and
treatment of urological diseases. In addition, each tissue and cellular specimen
received and reviewed by the UroDiagnostics Group is
 
                                       28
<PAGE>
entered into  the database,  and the  Company's contractual  relationships  with
academic  and research centers provide additional specimens. Using the Company's
large and comprehensive database, UroCor's  scientists are able to evaluate  new
technologies  or techniques under  development against samples  in the Company's
database, facilitating determination of  the clinical contribution of  potential
new  products.  The  scientific  research  and  product  development  activities
conducted by the Company's UroSciences Group  constitute a key component of  the
Company's  efforts to  build an  integrated disease  management company  for the
urology market.
 
    The primary  purpose  of the  UroSciences  Group is  to  develop  additional
diagnostic products and technologies for commercialization by the UroDiagnostics
Group.  The  following  table  sets  forth  the  current  principal  development
programs.
<TABLE>
<S>                                       <C>
                              UROSCIENCES DEVELOPMENT PROGRAMS
 
<CAPTION>
 
          DEVELOPMENT PROGRAM                            PROPOSED APPLICATION
- ----------------------------------------  --------------------------------------------------
<S>                                       <C>
 PROSTATE CANCER
  SERUM BASED
    RT-PCR PSA                            Assists in staging and monitoring disease
    Gene discovery                        Enhances cancer-specific detection and monitoring
  TISSUE BASED
    Molecular and antibody markers        Assesses tumor progression and response to therapy
    Computer assisted image analysis      Assesses tumor progression and staging pre-surgery
                                          and predicts progression post-surgery
 
 PROSTATITIS
  URINE BASED
    Microbiological techniques            Differentiates microbial prostatitis
    Molecular markers                     Identifies non-culturable microorganisms
 
 BENIGN PROSTATIC HYPERPLASIA
    Antibody and molecular markers        Selects and monitors medical therapy
    Gene discovery                        Selects and monitors medical therapy
 
 BLADDER CANCER
  URINE BASED -- CELLULAR
    Antibody and molecular markers        Enhances detection, diagnosis and prognosis
    Computer assisted image analysis      Enhances detection, diagnosis and prognosis
  SOLUBLE
    Antibody markers                      Enhances detection, diagnosis and prognosis
 
 INTERSTITIAL CYSTITIS
  URINE BASED -- CELLULAR AND SOLUBLE
    Molecular and antibody markers        Assists in definitive diagnosis and monitors
                                          response to new therapies
</TABLE>
 
    PROSTATE  CANCER.    UroCor  is  developing  a  technology  called   reverse
transcriptase/polymerase  chain  reaction  ("RT-PCR") to  detect  prostate cells
circulating in the blood  which could be relevant  to the metastatic process  in
this  disease.  UroCor  is sponsoring  three  investigational  collaborations to
determine  the   clinical  significance   and  the   potential  for   commercial
applications of the information provided
 
                                       29
<PAGE>
by  this  technology. The  Company  also has  discovered  and is  evaluating the
application of novel genes that are differentially expressed in prostate  cancer
and  benign prostatic hyperplasia ("BPH") that may provide better diagnostic and
prognostic tools.
 
    The UroSciences  Group has  developed computer  assisted image  analysis  of
individual  cancer  cells in  order to  create statistical  models, mathematical
formulae  and  artificial  neural  network  systems  for  facilitating   disease
management  decisions in  prostate and  bladder cancer.  The Company  expects to
develop within the next 18 months commercial applications of this technology for
diagnostic  use   to  improve   the  urologist's   ability  to   determine   the
aggressiveness  of  a patient's  disease and  to  make more  objective treatment
decisions.
 
    PROSTATITIS.  The  Company currently is  developing analytical services  for
the  detection, diagnosis  and monitoring  of acute  and chronic  prostatitis, a
disease characterized by inflammation of the prostate. This disease has  complex
causes and poses difficulties in detection and diagnosis. UroCor is developing a
testing  service planned  for commercial introduction  in 1997 to  assist in the
diagnosis of this disease.
 
    BENIGN PROSTATIC  HYPERPLASIA.   UroCor  is  developing a  product  for  the
diagnosis  of BPH, a prostate disease  that is estimated to affect approximately
50% of all men over age 50. The Company has developed and licensed molecular and
other technologies which it believes  may improve the differential diagnosis  of
BPH  as distinguished  from prostate cancer  and improve the  process of medical
therapy selection.
 
    BLADDER CANCER.   The Company  is developing a  combination of  technologies
which it believes will further enhance its ability to detect early-stage bladder
cancer  and provide the urologist with  diagnostic and prognostic information to
assist in more effective management of  the patient's care. The Company  intends
to  combine specific  biomarkers licensed  from or  supplied by  others with the
Company's computer-assisted image analysis  technology to increase the  accuracy
of the broad range of products the Company presently provides for bladder cancer
management.
 
    INTERSTITIAL  CYSTITIS.  The Company is  developing a product to improve the
diagnosis of  interstitial cystitis,  a debilitating  bladder disorder  that  is
estimated  to affect up  to 450,000 persons in  the United States, approximately
90% of whom are  women. UroCor's product is  directed at providing a  definitive
diagnosis for the disease.
 
    UROTHERAPEUTICS GROUP
 
    UroCor  intends  to  provide  through  its  UroTherapeutics  Group  selected
therapies to urologists for the care  of patients in an office environment.  The
Company   plans  to  license,  acquire   from  others  or  co-market  urological
pharmaceutical products used in the urologist's office and to capitalize on  its
existing specialized sales force to market these products to its existing client
base.  In contrast  to pharmaceutical  companies that  typically market  a broad
range of  products, the  Company intends  to leverage  its focused  approach  by
marketing  therapeutic products  and related  services of  particular benefit to
urologists. The Company also plans to offer ancillary products and services such
as  computerized  order  entry,  just-in-time  inventory,  procedure  trays   to
accompany   therapeutic  interventions,  database  access  and  oncologist  case
consultation as well as reimbursement assistance.
 
    In December  1994,  the  Company  entered into  an  agreement  with  BioVac,
granting exclusive distribution rights in the United States for a strain of BCG,
a  therapeutic  product for  treating certain  types of  bladder cancer.  BCG is
delivered directly into a patient's bladder  by the urologist using a  catheter,
generally  in  an office-based  procedure. The  current BCG  treatment procedure
includes an initial series of six such doses over a six-week period, and  recent
studies  have indicated  that additional maintenance  doses of  BCG delivered at
lengthening intervals may be effective in delaying or eliminating recurrence  of
bladder cancer.
 
    Pursuant  to the distribution agreement, BioVac is responsible for obtaining
approvals from the FDA  for marketing the product  in the United States.  UroCor
may  not commence  selling the  product in  the United  States until  BioVac has
obtained  such  FDA  approval.   In  April  1995,   BioVac  filed  its   initial
 
                                       30
<PAGE>
applications  with the  FDA. BioVac  has informed the  Company that  in a letter
dated  April  18,  1996,  the  FDA  advised  BioVac  that  its  product  license
application is not approvable at this time and that the FDA requested additional
data  regarding certain  aspects of  manufacturing and  testing of  the product.
BioVac  has  advised  the  Company  that  notwithstanding  the  receipt  of  the
non-approvable  letter from the FDA, it believes it can satisfy FDA requirements
and procure approval for marketing the  product in the United States. There  can
be no assurance, however, that such approval will be obtained.
 
    In  the event the BCG product is not  approved by the FDA prior to April 18,
1997, the Company has the right to terminate the distribution agreement. In  the
event  the FDA approves marketing  of the BCG product  in the United States, the
Company's ability to maintain its  exclusive distribution rights is  conditioned
upon meeting certain minimum sales requirements.
 
    In  addition to the  proposed BCG product,  the Company plans  to pursue the
license or acquisition  of other therapeutic  products for distribution  through
its  specialized sales  force. The  Company has no  current plans  to develop or
manufacture therapeutic products.
 
    DISEASE MANAGEMENT INFORMATION SYSTEMS
 
    UroCor believes that useable, relevant information provides one of the  most
important  components  of disease  management services.  The Company  intends to
capitalize on its existing relationships with its urologist clients and  managed
care  organizations and its  existing information resources  to help improve the
clinical management  of  patients  as  well as  its  clients'  productivity  and
profitability.
 
    SECURE  WIDE  AREA NETWORK.   The  Company's Disease  Management Information
Systems group  is developing  a secure  wide area  network that  is intended  to
enhance  two-way communication between UroCor and its physician client base. The
Company  will  initially   focus  application   of  this   network  toward   the
UroDiagnostics  Group. Through this network, a physician will be able to order a
specimen collection kit, send patient and billing information to the Company  in
advance  of  a specimen,  receive advanced  case  reports on  current diagnostic
findings, request a status update for any specimens currently in the  processing
queue  and request a consultation with one of the Company's 11 pathologists. The
Company also intends to develop applications for this network that would  permit
its  clients to  access the  Company's database  as an  educational and practice
management resource.
 
    CLINICAL DECISION  SUPPORT  SYSTEMS.   The  Company is  developing  software
applications  using the UroSciences  Group's database of  thousands of patients'
cellular, tissue and serum  specimens to assist the  urologist in the  prognosis
and  treatment of urological diseases. The  Company initiated development of the
first generation of its proprietary disease pathway computer models for prostate
cancer and  bladder cancer  during  1993. These  models  integrate much  of  the
relevant  published literature on medical practice, technology and various costs
and claims databases to model diagnostic and therapeutic intervention points  in
these  diseases from the detection stage through  the point at which the disease
is either cured or is determined to be incurable.
 
    MANAGEMENT SERVICES.  The Company  believes that two-way computer access  to
its  clients' offices will enhance the  Company's ability to retain its existing
clients and  expand  the  number of  products  and  product types  used  by  its
customers  because of the convenience and  ease of product ordering and transfer
of patient and practice  information. UroCor believes that  this access and  the
Company's  active involvement  in clinical  practice management  present further
opportunities to  assist  the  urologist  with  billing,  collection  and  other
practice management and productivity information processing.
 
COMPETITION
 
    The  market  for providing  urologists and  managed care  organizations with
disease management  systems and  services  is still  emerging, and  the  Company
believes that no other company currently is providing the comprehensive approach
pursued by the Company.
 
    The  market for  providing urologists  with specialized  clinical diagnostic
services  for  detection,   diagnosis,  prognosis  and   monitoring  is   highly
competitive  and  fragmented.  The majority  of  this  market is  served  by the
hundreds of local free-standing or hospital-pathology services for the  cellular
and tissue
 
                                       31
<PAGE>
diagnostic  services offered  by the  Company, and  other hospital laboratories,
specialty laboratories and  general reference laboratories  provide some of  the
serum  testing provided by the Company.  The main competitive advantage of local
hospital  pathology  service  providers  is  long-established  local   physician
referral  practices.  The general  reference laboratories'  competitive strength
lies in their service capabilities to provide local couriers for specimen pickup
and broad-based  contracting  ability  with managed  care  organizations.  Other
companies  that already market diagnostic products and medical supplies in other
fields  have  begun  marketing  kits  for  detecting  certain  cancers  in   the
urologist's  office. The Company believes  that it will be  able to compete with
these diagnostic service providers because  of its disease management  approach,
its broad range of diagnostic products and services, its urology-dedicated sales
force and its focused product research and development efforts.
 
    In the therapeutics segment of the urology market, both surgery performed by
the  urologists and  a number  of chemotherapeutic  drugs will  compete with the
Company's proposed BCG therapy product  for bladder cancer. Two other  companies
Connaught  Laboratories,  Inc.  and  Organon, Inc.,  already  are  marketing BCG
products  in  the  United  States.  Many  major  and  mid-sized  pharmaceuticals
companies   which  can  deploy  larger  sales  organizations  and  research  and
development efforts compete for sales of other urological drugs. Because of  its
existing  relationships  with urologists  through  its UroDiagnostics  Group and
existing specialized sales force, the Company  believes that it has the  ability
to compete in this market.
 
    Information  systems companies  provide software products  that will compete
with proposed Company products that enable a urologist to store patient  records
and  practice information. In addition, other companies are building regional or
national databases focused on improving  clinical and economic disease  outcomes
similar  to the  Company's application of  its urological  disease database. The
main competitive advantage of  these companies is their  knowledge and focus  on
software  and  system development.  Many  of these  companies  have considerably
greater resources and experience than the Company in the development of software
and information systems, and could gain effective access to the urologists.  The
Company  believes that the  principal competitive factors  for clinical outcomes
database software are the quality and depth of the underlying clinical  outcomes
database,  the usefulness  of the  data and  reports generated  by the software,
customer service  and support,  ease-of-use, compatibility  with the  customer's
existing  information systems,  potential for  product enhancements,  and vendor
reputation. The Company believes that its  ability to compete in this area  lies
in its expertise and focus on urology.
 
    The  Company also competes with  many biotechnology companies, manufacturers
of diagnostic systems and  kits as well as  other producers and distributors  of
medical  products for  the acquisition  of technology  for research  and product
development. The Company believes its own product and technology development and
evaluation capabilities together with its  expertise in urological diseases  and
market access provide it with the ability to compete successfully in this area.
 
    Many  of  the  Company's  competitors  are  significantly  larger  and  have
significantly greater financial, technical and administrative resources than the
Company. Many  also  have  long-established  relationships  with  the  Company's
current and prospective customers. See "Risk Factors -- Competition".
 
GOVERNMENT REGULATION
 
    The  health care industry in  the United States is  highly regulated and the
diagnostic service segment, which  includes the Company's UroDiagnostics  Group,
is  no exception. The  Company's diagnostic laboratory  operations currently are
not regulated by the FDA. While the FDA  now indicates that it does not plan  to
regulate  assays developed by laboratories for in-house use, the FDA in the past
has drafted guidelines for regulation of such  assays. If in the future the  FDA
were  to  issue  guidelines  for the  clinical  laboratory  market  sector, such
guidelines might require the Company to meet certain FDA medical device approval
requirements for the Company's in-house assays. The FDA currently regulates some
of the tests and systems purchased by the Company from third parties and used in
the Company's  diagnostics  business. The  manufacturers  of such  products  are
responsible  for compliance with  the approval and  marketing regulations of the
FDA.   If    the   UroSciences    Group   should    decide   to    market    any
 
                                       32
<PAGE>
of its diagnostic technology as test kits to be used by third parties, such test
kits  would  require  FDA  approval.  The  Company  performs  extensive internal
validation procedures and selected independent clinical trials on new tests  and
markers  which it intends  to market. While  no assurances may  be given in such
regard, the Company believes that it  could adjust to any reasonable changes  in
applicable  FDA requirements without significant disruption or financial impact.
In the event that  any such changes are  more extensive than anticipated,  these
changes  would increase  the cost of  development and approval  of new products,
slow their introduction to the market  and could have a material adverse  effect
on the Company's financial condition and results of operations.
 
    The  Company's  business  is  also  subject  to  a  variety  of governmental
regulations at  the federal,  state  and local  levels. The  Company's  clinical
laboratory  is  certified  under  the federal  Medicare  program,  certain state
Medicaid programs and  CLIA. The  Company also  is licensed  under the  clinical
laboratory  licensure laws of Oklahoma,  where the Company's clinical laboratory
is located. Since  the Company  provides clinical testing  services to  patients
nationwide,  its laboratory is  also licensed under  the laws of  those state or
local governments which the Company is aware have clinical laboratory regulation
programs applicable to  out-of-state laboratories. The  Company believes it  has
obtained all such licenses required for its operations.
 
    In  addition,  certain  regulatory authorities  require  participation  in a
proficiency testing program approved by  the United States Department of  Health
and  Human Service ("DHHS")  for each of the  specialties and subspecialties for
which a laboratory seeks approval from Medicare or Medicaid and licensure  under
CLIA. Proficiency testing programs involve actual testing of specimens that have
been  prepared  by an  entity running  an  approved program  for testing  by the
laboratory. The Company believes  it is in compliance  in all material  respects
with all such applicable regulations.
 
    The  federal Social  Security Act  imposes criminal  penalties and exclusion
from the Medicare program upon persons who make or receive kickbacks, bribes  or
rebates  in  connection  with  the  Medicare  program.  The  anti-kickback rules
prohibit providers and  others from soliciting,  offering, receiving or  paying,
directly  or indirectly, any remuneration in return for either making a referral
for a Medicare-covered service or item  or ordering any such covered service  or
item.  Because the Medicare  and certain related  state anti-kickback rules have
been broadly  interpreted, they  could limit  the manner  in which  the  Company
conducts  its business. The Company believes that it currently complies with the
anti-kickback rules  in its  activities.  No assurance  can be  given,  however,
regarding  compliance in any particular factual situation, as there is currently
no procedure for advisory opinions from government officials.
 
    Under another  provision,  known  as  the  "Stark"  law  or  "self-referral"
prohibition, physicians who have an investment or compensation relationship with
an entity furnishing clinical laboratory services (including pathology services)
may  not, subject to certain exceptions,  refer clinical laboratory analyses for
Medicare patients to that entity. Similarly, facilities may not bill Medicare or
any other  party  for services  furnished  pursuant to  a  prohibited  referral.
Violation  of these provisions may result in disallowance of Medicare claims for
the affected analysis  services, as  well as  the imposition  of civil  monetary
penalties  and program  exclusion. A  number of  states, including  New York and
California,  have  enacted  similar  prohibitions  to  the  Stark  law  covering
referrals  of non-Medicare as  well as Medicare business.  These state rules are
very restrictive,  prohibit  submission of  claims  for payment  for  prohibited
referrals  and  provide  for  the  imposition  of  civil  monetary  and criminal
penalties. The Company believes it has  no prohibited relationships with any  of
its  referrers, however, the Company is unable  to predict how these laws may be
applied in the future, or whether the federal government or states in which  the
Company  operates will enact  more restrictive legislation  or restrictions that
could affect the Company's operations under certain circumstances.
 
    Any exclusion or suspension from participation in the Medicare program,  any
loss  of  licensure or  accreditation or  any inability  to obtain  any required
license or permit, whether arising from any action
 
                                       33
<PAGE>
by DHHS, any  state or  any other regulatory  authority, would  have a  material
adverse  effect on  the Company's  business. Any  significant civil  monetary or
criminal penalty resulting from such  proceedings could have a material  adverse
effect on the Company's financial condition and results of operations.
 
    The  laws of many states prohibit  physicians from sharing professional fees
with non-physicians and  prohibit non-physician entities,  such as the  Company,
from  practicing medicine (including pathology) and from employing physicians to
practice medicine (including pathology). The  laws in most states regarding  the
corporate  practice  of medicine  have been  subjected  to limited  judicial and
regulatory  interpretation.  The  Company  believes  its  current  and   planned
activities do not constitute prohibited fee splitting or violate any prohibition
against  the corporate practice of medicine. There can be no assurance, however,
that future  interpretations  of  such  laws  will  not  require  structural  or
organizational modifications of the Company's existing business.
 
    Pursuant  to the  federal Occupational  Safety and  Health Act, laboratories
have a general duty  to provide a  work place for their  employees that is  safe
from  hazard. The  United States  Occupational Safety  and Health Administration
("OSHA") has issued  rules relevant  to certain hazards  that are  found in  the
laboratory. In addition, OSHA issued a standard in 1992 applicable to protection
of  workers from  blood-borne pathogens.  Failure to  comply with  this standard
relating to  blood-borne pathogens,  other  applicable OSHA  rules or  with  the
general duty to provide a safe work place could subject an employer, including a
laboratory employer such as the Company, to substantial fines and penalties.
 
THIRD-PARTY REIMBURSEMENT
 
    In 1993, 1994, 1995 and the first three months of 1996, the Company received
approximately  56%, 58%, 58% and 53%, respectively, of its revenue from services
performed principally for beneficiaries of  the Medicare program. Under law  and
regulation,  for most of the services  performed for Medicare beneficiaries, the
Company must accept reimbursement from Medicare  as payment in full, subject  to
applicable  co-payments and deductibles. In 1987,  1989 and 1990, federal budget
legislation  instituted  changes   in  Medicare's  fee   schedule  relating   to
reimbursement  for  laboratory  services.  Each  such  change  lowered  Medicare
reimbursement schedules. Other  legislative proposals have  been made which,  if
enacted, could have an adverse effect on reimbursement of laboratory services.
 
    Reimbursement rates for most of the Company's services have been established
by  Medicare and some third-party  payors, but have not  been established by all
insurance carriers. Although substantially all of the Company's current services
receive reimbursement at various rates or  on a case-by-case basis, some of  the
services  that the  Company may  provide in  the future  may not  be approved by
Medicare or  some  other third-party  payors  and reimbursement  rates  on  such
services  cannot be predicted.  The Company cannot collect  from Medicare or any
other third-party payor  for services  not approved by  them for  reimbursement.
Approval by Medicare or other federal agencies does not assure approval by other
third-party   payors.  Most  third-party  payors,  including  Medicare,  do  not
reimburse for services that they  determine to be experimental,  investigational
or  otherwise not reasonable and necessary  for diagnosis or treatment. A formal
coverage determination  is made,  however, with  respect to  relatively few  new
procedures.  When such determinations do occur  for Medicare purposes, they most
commonly are  made by  the local  Medicare carrier  which processes  claims  for
reimbursement  within the carrier's geographic  jurisdiction. Medicare may audit
and review its prior payments to the Company, and may determine that certain  of
those payments must be refunded.
 
INTELLECTUAL PROPERTY
 
    The  Company  has  completed  numerous license  and  option  agreements with
academic centers and biotechnology  companies covering technologies it  believes
may be of utility in the future in improving urological disease management. Most
of  these arrangements provide the Company exclusive commercial rights worldwide
in all human  diagnostics and several  also provide the  option for  therapeutic
applications.
 
    The   Company  licenses  patents  and  seeks  patents  when  appropriate  on
inventions concerning  new products  and  improvements as  part of  its  ongoing
research, development and marketing efforts. While
 
                                       34
<PAGE>
the  Company believes these technologies  and particularly any patent protection
which may  become available  should  help the  Company improve  its  competitive
position  in its  market, the  Company presently  is not  dependent on  any such
patents and does not expect to become dependent on patents in the future.
 
    The Company attempts to protect its proprietary products by relying on trade
secrets and  on  non-disclosure  and  confidentiality  agreements.  The  Company
requires  its  employees,  consultants,  outside  scientific  collaborators  and
sponsored researchers and other  advisors to execute confidentiality  agreements
upon  the  commencement  of  employment  or  consulting  relationships  with the
Company. These agreements  generally provide that  all confidential  information
developed or made known to the individual during the course of the relationships
is  to be kept confidential  and not to be disclosed  to third parties except in
specific circumstances. In the  case of employees,  the agreements provide  that
any  inventions  conceived by  the individual  within  the scope  of his  or her
employment shall  be the  exclusive property  of the  Company. There  can be  no
assurance, however, that these agreements will provide meaningful protection for
any  of  the  Company's  trade  secrets in  the  event  of  unauthorized  use or
disclosure of such information.
 
    The Company intends to  seek copyright protection  when appropriate for  any
information systems products it may develop.
 
    The  Company has  registered the service  marks UROCOR-Registered Trademark-
and UROSCORE-Registered Trademark- with the  United States Patent and  Trademark
Office.
 
ENVIRONMENTAL MATTERS
 
    The  Company is  subject to federal,  state and local  laws, regulations and
policies governing  the use,  generation,  manufacture, storage,  air  emission,
effluent  discharge,  handling  and disposal  of  certain  materials, biological
specimens and wastes. Although the Company believes that it has complied in  all
material  respects with  these laws, regulations  and policies and  has not been
required to  take any  action to  correct  any noncompliance,  there can  be  no
assurance  that the Company will  not be required to  incur significant costs to
comply with environmental and health and safety regulations in the future.
 
    The Company's research and development activities involve the controlled use
of hazardous  materials, including  certain hazardous  chemicals and  infectious
biological  specimens. Although the Company  believes that its safety procedures
for  handling  and  disposing  of  such  materials  comply  with  the  standards
prescribed   by  state   and  federal   regulations,  the   risk  of  accidental
contamination or injury from these materials cannot be eliminated. In the  event
of  such an  accident, the  Company could  be held  liable for  any damages that
result and any such liability could exceed the resources of the Company.
 
EMPLOYEES
 
    At May 1, 1996, the Company had 208 full-time and 37 part-time employees, of
which 89 were  employed in  diagnostic services  operations and  support, 94  in
sales and marketing, 23 in research and development and 39 in administration and
accounting.  At May 1,  1996, the Company  employed, full time,  11 persons with
M.D. degrees and six persons with  Ph.D. degrees. The Company believes that  its
relationship with its employees is good.
 
FACILITIES AND OPERATIONS
 
    The Company leases approximately 48,000 square feet of administration, sales
and  marketing, operations and research and  development space in Oklahoma City,
Oklahoma. The Company's  initial lease term  expires in June  2005 which may  be
extended  at the Company's option for an  additional five years. The Company has
rights of first refusal  to lease additional  space in the  rest of the  110,000
square foot building as well as a purchase option on the building. The Company's
monthly rental obligation for its facilities currently is approximately $32,000.
The  Company believes  that its leased  facilities are adequate  for its current
needs and that suitable, additional space will be available on acceptable  terms
for the foreseeable future.
 
                                       35
<PAGE>
                                   MANAGEMENT
 
DIRECTORS, EXECUTIVE OFFICERS AND KEY EMPLOYEES
 
    The  following table sets forth information as of May 1, 1996, regarding the
executive officers, directors and certain key employees of the Company.
 
<TABLE>
<CAPTION>
NAME                                     AGE      POSITION
- -----------------------------------      ---      -------------------------------------------------
<S>                                  <C>          <C>
William A. Hagstrom................      38       Chairman of the Board, President and
                                                  Chief Executive Officer
Socrates H. Choumbakos.............      51       Vice President, Corporate Development,
                                                  Chief Financial Officer and Secretary
Mark G. Dimitroff..................      49       Vice President and General Manager UroDiagnostics
                                                  Group
Robert W. Veltri, Ph.D.............      54       Vice President and General Manager UroSciences
                                                  Group
Kathryn L. W. Ingerly..............      37       Vice President Disease Management Information
                                                  Systems
Gerard J. O'Dowd, M.D..............      45       Medical Director
Michael N. McDonald................      38       Director of Finance and Administration,
                                                  Treasurer and Assistant Secretary
Paul A. Brown, M.D.(1)(2)..........      58       Director
Herbert J. Conrad(2)...............      63       Director
Michael E. Herbert(1)..............      51       Director
Louis M. Sherwood, M.D.............      59       Director
Don E. Spyrison....................      50       Director
Joe D. Tippens(2)..................      38       Director
</TABLE>
 
- --------------------------
(1) Member of Compensation Committee.
 
(2) Member of Audit Committee.
 
    WILLIAM A. HAGSTROM.  Mr.  Hagstrom has been a  director of the Company  and
served  as President and  Chief Executive Officer of  the Company since November
1989. Mr. Hagstrom was appointed Chairman of the Board of Directors in September
1994. Before  joining  the Company,  Mr.  Hagstrom  was Vice  President  of  the
Scientific  Products Division  of Baxter-Travenol,  a medical  products company,
where he  served  in various  marketing,  sales, product  planning  and  general
management  positions  from November  1985 to  November  1989. Prior  to joining
Baxter-Travenol, he spent three years at American Hospital Supply Corp. until it
was acquired by  Baxter-Travenol and three  years at Becton  Dickinson & Co.  in
various management positions.
 
    SOCRATES  H. CHOUMBAKOS.  Mr. Choumbakos joined  the Company in June 1992 as
Vice President, Corporate  Development, Chief Financial  Officer and  Secretary.
Before  joining the Company, Mr. Choumbakos was President of Venture Development
Group, a corporate and business development consulting firm, from March 1988  to
June  1992.  From March  1988 to  December  1990, Mr.  Choumbakos was  also Vice
President and Chief Financial Officer  of Creative Business Strategies, Inc.,  a
business  development  consulting  firm. From  August  1979 to  March  1988, Mr.
Choumbakos was Director of  Corporate Development at Becton  Dickinson & Co.,  a
medical  products company.  Prior to  1979, he was  a Senior  Manager with Price
Waterhouse & Co. where he worked for 13 years.
 
    MARK G. DIMITROFF.   Mr. Dimitroff joined  the Company in  May 1990 as  Vice
President,  Marketing and  Sales and became  Vice President  and General Manager
UroDiagnostics Group in October 1994. Before joining the Company, Mr.  Dimitroff
served  as  Vice President,  Marketing and  Sales for  Dianon Systems,  Inc., an
oncology specialty reference laboratory, from 1984  to May 1990. Prior to  1984,
he  held senior  marketing and sales  management positions with  MetPath Inc., a
large general reference laboratory, and American Hospital Supply Corp.
 
                                       36
<PAGE>
    ROBERT W. VELTRI, PH.D.   Dr. Veltri joined the  Company in October 1990  as
Vice President, Product Planning and Technology Development and Chief Scientific
Officer,  and became  Vice President  and General  Manager UroSciences  Group in
October 1994. Before  joining the  Company, Dr.  Veltri was  the Executive  Vice
President  and  Chief  Technical  Officer  at  Theracel,  Inc.,  a  therapeutics
development company, from 1988  to October 1990. From  1984 to 1988, Dr.  Veltri
was   a  founder  and   President  and  Chief   Executive  Officer  of  American
Biotechnology Company,  the predecessor  to Theracel,  Inc. Prior  to 1984,  Dr.
Veltri  was Director of Research and Development for the Immunology Group (rapid
IN VITRO diagnostic test  development) at Cooper  Biomedical Inc., a  diagnostic
products  company, and  was Professor of  Microbiology and  Surgery, Director of
Research in Otolaryngology and Supervisor of the Special Immunology and Virology
Clinical Laboratory at West Virginia University Medical School for 13 years.
 
    KATHRYN L. W. INGERLY.  Ms. Ingerly joined the Company in April 1996 as Vice
President, Disease Management Information  Systems. Before joining the  Company,
Ms.  Ingerly was the  President and Chief Executive  Officer of Ingerly Alliance
Partners, L.L.C.,  an information  technology consulting  company since  January
1995.  From  September  1988 through  December  1994, Ms.  Ingerly  held various
positions with Market Investment Solutions, a software development and  services
company,  most recently as President and Chief Executive Officer. Prior to 1988,
Ms. Ingerly was the Financial and Systems Manager of the Cleo Wallace Center,  a
regional health care provider in Denver, Colorado.
 
    GERARD  J. O'DOWD,  M.D.  Dr.  O'Dowd joined  the Company in  August 1990 as
Medical Director. Before joining the Company, Dr. O'Dowd was in private practice
specializing in fine needle aspiration cytology and served as a pathologist  for
a  regional reference laboratory in the  Washington, D.C. area from January 1988
to August 1990. From 1983  to December 1987, Dr. O'Dowd  served on the staff  of
George Washington Medical Center where he was Chief Pathologist for the Division
of  Cytopathology  and  Hematopathology.  He received  his  medical  degree from
Georgetown University School of Medicine, completed a pathology residency at the
University of Utah  and was  a Cytopathology Fellow  at the  Medical College  of
Virginia.
 
    MICHAEL  N.  MCDONALD.   Mr. McDonald  joined  the Company  in June  1992 as
Controller  and  Assistant  Secretary  and   became  Director  of  Finance   and
Administration  and Treasurer in  October 1994. Before  joining the Company, Mr.
McDonald was a Manager in the  Accounting and Audit Division at Arthur  Andersen
LLP where he served in various capacities from December 1980 to June 1992.
 
    PAUL  A. BROWN, M.D.  Dr. Brown has  been a director since November 1988. He
has been Chairman  of the Board  and Chief  Executive Officer of  HeaRx Ltd.,  a
medical products and services company, for the past six years. Prior to founding
HeaRx, Dr. Brown was founder and Chairman of the Board of MetPath Inc. Dr. Brown
is  currently on the Board of Trustees of Tufts University, past Chairman of the
Board of Overseers of the Tufts University  School of Medicine, a member of  the
visiting  committee  of Boston  University School  of  Medicine and  a part-time
member of the Columbia University College of Physicians and Surgeons.
 
    HERBERT J. CONRAD.  Mr. Conrad has been a director since October 1993. Until
his retirement in August 1993, Mr. Conrad  served for more than five years as  a
senior  executive with  Hoffmann-LaRoche, Inc.,  a pharmaceutical  company, most
recently  as  a   director,  Senior   Vice  President  and   President  of   the
Pharmaceuticals Division. Mr. Conrad has more than 30 years of experience in the
pharmaceutical  industry, primarily with Hoffmann-LaRoche, where he held several
senior management positions  in marketing, business  and strategic planning  and
public   affairs.  Mr.  Conrad  has  also   served  as  a  director  of  several
pharmaceutical-related companies, including Dura Pharmaceuticals,  Biotechnology
General and Bradley Pharmaceuticals.
 
    MICHAEL  E. HERBERT.  Mr.  Herbert has been a  director since July 1994. Mr.
Herbert has served  for more than  five years as  President and Chief  Executive
Officer  of Physicians Health Services, Inc., an individual practice association
health maintenance organization ("IPA/HMO")  serving members in Connecticut  and
New  York.  Under  Mr.  Herbert's  direction,  Physicians  Health  Services  has
developed over the past  19 years into New  England's first federally  qualified
IPA/HMO. Prior to joining Physicians
 
                                       37
<PAGE>
Health Services, Mr. Herbert was Vice President of InterStudy, a national health
policy  research firm  focusing on  a marketplace  approach to  health care. Mr.
Herbert is the past Chairman of the American Managed Care and Review Association
and was Charter President of the Association of Connecticut HMOs.
 
    LOUIS M. SHERWOOD,  M.D.   Dr. Sherwood has  been a  director since  October
1993.  Since 1987, Dr. Sherwood has been Senior Vice President, U.S. Medical and
Scientific Affairs,  of Merck  &  Co., a  pharmaceutical company.  His  academic
appointments  include seven  years as Baumritter  Professor and  Chairman of the
Department of  Medicine at  Albert Einstein  College of  Medicine, Professor  of
Biochemistry and Physician in Chief at Montefiore Medical Center, eight years as
Chairman  of  Medicine at  the  Michael Reese  Medical  Center and  Professor of
Medicine at the University of Chicago. He also served as Chief of  Endocrinology
at  Beth Israel Hospital and Assistant  Professor of Medicine at Harvard Medical
School.
 
    DON E. SPYRISON.  Mr. Spyrison has been a director since November 1989. From
October 1988 to November 1989, he served as President, and from November 1990 to
September 1994, he  served as Chairman  of the  Board. Mr. Spyrison  has been  a
general  partner of The Woodlands Venture Partners, L.P., the general partner of
The Woodlands  Venture  Fund, L.P.,  a  venture  capital firm  and  a  principal
stockholder  of the Company, since November  1988. Since September 1994, he also
has served as special limited  partner of the Woodlands-Essex Venture  Partners,
L.P., a venture capital firm. Since September 1995, he has been serving as Chief
Executive  Officer and director  of Protocol Work  Systems, Inc., an information
systems company. Mr. Spyrison was a  director and President and Chief  Executive
Officer  of Optex Biomedical, Inc., a medical device company, from April 1992 to
December 1995, at  which time  Optex filed  for relief  under Chapter  7 of  the
federal bankruptcy laws.
 
    JOE D. TIPPENS.  Mr. Tippens has been a director since May 1991. Mr. Tippens
has  been President  and Managing Director  of Chisolm Private  Capital, Inc., a
venture capital  firm, since  May 1994  and  also serves  as consultant  to  the
management  company  to ML  Oklahoma  Venture Partners,  Limited  Partnership, a
venture capital firm and a principal  stockholder of the Company. From  November
1988  until May 1994, Mr. Tippens was  a Vice President of Merrill Lynch Venture
Capital Inc., a  venture capital firm  and an affiliate  of ML Oklahoma  Venture
Partners,  Limited  Partnership. From  1983 through  November 1988,  Mr. Tippens
worked privately in the venture capital industry. Prior to 1983, Mr. Tippens was
a Manager  in the  Audit  Division of  Arthur Andersen  LLP.  Mr. Tippens  is  a
director of Silverado Foods, Inc., a food products distribution company.
 
CLASSIFIED BOARD
 
    The Restated Certificate of Incorporation provides for the classification of
the  Board of Directors into  three classes of directors  (Class I, Class II and
Class  III),  with  the  term  of  each  class  expiring  at  successive  annual
stockholders'  meetings. At and  after the 1997  Annual Meeting of Stockholders,
all nominees of the class standing  for election will be elected for  three-year
terms.  The terms of office for Messrs.  Spyrison and Tippens expire at the 1997
Annual Meeting  of Stockholders,  the terms  of  office of  Mr. Conrad  and  Dr.
Sherwood  expire at the  1998 Annual Meeting  of Stockholders, and  the terms of
office of Dr.  Brown, Mr. Herbert  and Mr.  Hagstrom expire at  the 1999  Annual
Meeting of Stockholders.
 
COMMITTEES
 
    The Board of Directors of the Company has established an Audit Committee and
a  Compensation Committee. The  Audit Committee is  charged with recommending to
the Board of Directors  the appointment of  the Company's independent  auditors,
reviewing  the compensation of such auditors and reviewing with such accountants
the plans  for and  the results  and  scope of  their auditing  engagement.  The
Compensation  Committee reviews  the performance and  compensation of directors,
executive officers and key employees and  makes recommendations to the Board  of
Directors  with respect thereto. The Compensation Committee also administers the
Company's Amended and Restated  1992 Stock Option Plan  (the "1992 Stock  Option
Plan").
 
                                       38
<PAGE>
COMPENSATION OF EXECUTIVE OFFICERS
 
    COMPENSATION
 
    The  following table sets forth all compensation  paid by the Company to its
Chief Executive Officer and each of its executive officers as to whom the  total
annual salary and bonus for the year ended December 31, 1995, exceeded $100,000.
 
                           SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                                                        LONG-TERM
                                                                                                      COMPENSATION
                                                                               ANNUAL COMPENSATION   ---------------
                                                                                                       SECURITIES
                                                                               --------------------    UNDERLYING
NAME AND PRINCIPAL POSITION                                                     SALARY      BONUS      OPTIONS(1)
- -----------------------------------------------------------------------------  ---------  ---------  ---------------
<S>                                                                            <C>        <C>        <C>
William A. Hagstrom
 Chairman of the Board, President and Chief Executive Officer................  $ 160,202  $  31,522        60,000
Socrates H. Choumbakos
 Vice President, Corporate Development, Chief Financial Officer and
 Secretary...................................................................    129,585     15,700        30,000
Mark G. Dimitroff
 Vice President and General Manager UroDiagnostics Group.....................    129,909     18,435        40,000
Robert W. Veltri, Ph.D.
 Vice President and General Manager UroSciences Group........................    126,404     15,431        30,000
</TABLE>
 
- ------------------------------
(1)  Represents shares issuable pursuant to options granted under the 1992 Stock
     Option Plan.
 
    The  following table sets forth  information concerning individual grants of
stock options made  during the  year ended  December 31,  1995, to  each of  the
executive officers named in the Summary Compensation Table.
 
              OPTION GRANTS IN FISCAL YEAR ENDED DECEMBER 31, 1995
 
<TABLE>
<CAPTION>
                                                          INDIVIDUAL GRANTS                       POTENTIAL REALIZABLE
                                      ----------------------------------------------------------    VALUE AT ASSUMED
                                        NUMBER OF                                                 ANNUAL RATES OF STOCK
                                       SECURITIES      % OF TOTAL                                  PRICE APPRECIATION
                                       UNDERLYING    OPTIONS GRANTED   EXERCISE OR                 FOR OPTION TERM(2)
                                         OPTIONS     TO EMPLOYEES IN   BASE PRICE    EXPIRATION   ---------------------
NAME                                   GRANTED(1)         1995          PER SHARE       DATE         5%         10%
- ------------------------------------  -------------  ---------------  -------------  -----------  ---------  ----------
<S>                                   <C>            <C>              <C>            <C>          <C>        <C>
William A. Hagstrom.................       60,000            14.9%      $    1.75      12/15/05   $ 774,600  $1,295,400
Socrates H. Choumbakos..............       30,000             7.4            1.75      12/15/05     387,300     647,700
Mark G. Dimitroff...................       40,000             9.9            1.75      12/15/05     516,400     863,600
Robert W. Veltri, Ph.D..............       30,000             7.4            1.75      12/15/05     387,300     647,700
</TABLE>
 
- ------------------------------
(1)  Represents shares issuable pursuant to options granted under the 1992 Stock
     Option Plan. Options vest 33 1/3% annually beginning December 29, 1996.
 
(2)  Future  value of grants assuming appreciation in market value of the Common
     Stock of 5% and 10% over the ten-year term of the options. The actual value
     realized may be greater  or less than the  potential realizable values  set
     forth in the table. Solely for purposes of determining the value of options
     at December 31, 1995, the Company has assumed that the fair market value of
     the Common Stock issuable upon exercise of options was $9.00 per share, the
     assumed  initial  public offering  price, since  the  Common Stock  was not
     traded in an established market prior to the Offering.
 
                                       39
<PAGE>
    None of  the executive  officers  named in  the Summary  Compensation  Table
exercised options in 1995. The following table sets forth information concerning
the value of unexercised options held by such persons at December 31, 1995.
 
                       OPTION VALUES AT DECEMBER 31, 1995
 
<TABLE>
<CAPTION>
                                                                  NUMBER OF
                                                            SECURITIES UNDERLYING        VALUE OF UNEXERCISED
                                                             UNEXERCISED OPTIONS        IN-THE-MONEY OPTIONS AT
                                                            AT DECEMBER 31, 1995         DECEMBER 31, 1995(1)
                                                         ---------------------------  ---------------------------
NAME                                                     EXERCISABLE  UNEXERCISABLE   EXERCISABLE  UNEXERCISABLE
- -------------------------------------------------------  -----------  --------------  -----------  --------------
<S>                                                      <C>          <C>             <C>          <C>
William A. Hagstrom....................................      63,987        102,659     $ 527,893    $    786,937
Socrates H. Choumbakos.................................      75,080         42,120       646,210         317,490
Mark G. Dimitroff......................................      19,690         53,128       162,443         398,306
Robert W. Veltri, Ph.D.................................      26,580         47,720       219,285         363,690
</TABLE>
 
- --------------------------
(1) The dollar values have been calculated by determining the difference between
    the  fair market value of the  securities underlying the options at December
    31, 1995, and  the exercise prices  of the options.  Solely for purposes  of
    determining  the  value of  options at  December 31,  1995, the  Company has
    assumed that  the  fair market  value  of  the Common  Stock  issuable  upon
    exercise of options was $9.00 per share, the assumed initial public offering
    price,  since the Common Stock was not traded in an established market prior
    to the Offering.
 
    EMPLOYMENT AGREEMENTS
 
    Mr. Hagstrom  entered  into an  employment  agreement with  the  Company  in
January  1990.  Under  the  terms  of such  agreement,  Mr.  Hagstrom  serves as
President and Chief  Executive Officer.  The term of  the agreement  is for  one
year,  with  automatic  renewals indefinitely  for  further  successive one-year
periods unless  terminated  by  either  party. The  Company  may  terminate  the
agreement  upon Mr. Hagstrom's death or disability or for cause (as that term is
defined therein). The Company  may terminate the agreement  at any time  without
cause,  provided that  the Company  continues to  pay Mr.  Hagstrom at  his then
current base  salary rate,  on a  monthly basis,  for six  months following  the
effective  date  of termination.  Pursuant to  the terms  of the  agreement, the
Company may pay Mr. Hagstrom bonuses in  such amounts as the Board of  Directors
in its sole discretion may determine.
 
    Messrs.  Choumbakos  and Dimitroff,  Dr. Veltri  and  Ms. Ingerly  each have
entered into agreements with the Company regarding the respective terms of their
employment. None of such agreements provide for fixed periods of employment. The
agreement with Mr. Choumbakos  provides for a current  base salary of  $134,820,
subject  to annual review, a bonus of up to  25% of his annual base salary and a
severance obligation of six months upon termination without cause. The agreement
with Mr. Dimitroff provides  for a current base  salary of $140,075, subject  to
annual  review, and a  bonus of up  to 30% of  his annual base  salary. In April
1996, the Company's Board of Directors  approved a severance obligation for  Mr.
Dimitroff  of  six  months upon  termination  of employment  without  cause. The
agreement with  Dr. Veltri  provides  for a  current  base salary  of  $134,724,
subject  to annual review, a bonus of up to  25% of his annual base salary and a
severance obligation of three  months upon termination  without cause. In  April
1996,  the Company's  Board of  Directors approved  an increase  in Dr. Veltri's
bonus to up to 30%  of his annual base salary  and an increase in his  severance
obligation  to  six months  upon termination  of  employment without  cause. The
agreement with  Ms. Ingerly  provides for  a current  base salary  of  $120,000,
subject  to annual review, a bonus of up to  30% of her annual base salary and a
severance obligation of three months upon termination without cause.
 
    BONUS PLAN
 
    In 1991, the Company established a management incentive compensation program
under which most full-time employees, including executive officers, are eligible
to receive cash  bonuses, subject  to the  Company achieving  certain sales  and
operating  income  levels  as  well  as  achievement  of  individual performance
criteria. Bonus  levels are  established  for each  individual, ranging  from  a
minimum of up to $1,000 per employee to a maximum of up to 40% of annual salary.
In  February 1993, the  Company paid $172,230  under the plan  for the 1992 plan
year, of which an aggregate of $102,254 was paid to the four executive  officers
named  in the Summary Compensation  Table. In March and  April 1994, the Company
 
                                       40
<PAGE>
   
paid a total  of $281,070 under  the plan for  the 1993 plan  year, of which  an
aggregate  of $119,539 was paid  to the four named  executive officers. In April
1995, the Company  paid a total  of $251,932 under  the plan for  the 1994  plan
year,  of which  an aggregate of  $81,088 was  paid to the  four named executive
officers. In April 1996, the Company paid a total of $399,529 under the plan for
the 1995 year,  of which an  aggregate of $100,157  was paid to  the four  named
executive officers.
    
 
COMPENSATION OF DIRECTORS
 
    Each  director receives reimbursement for  expenses related to attendance at
Board meetings. Mr. Conrad, Mr. Herbert and Dr. Sherwood each receive $1,500 for
each meeting of the Board of Directors attended.
 
1992 STOCK OPTION PLAN
 
   
    The Company's 1992  Stock Option  Plan is administered  by the  Compensation
Committee of the Board of Directors. Pursuant to the plan, options to acquire an
aggregate  of 1,400,000 shares of Common Stock may be granted to individuals who
are  employees,  officers,  directors  or  independent  contractors   performing
services  for the  Company. As  of May 10,  1996, options  to purchase 1,001,594
shares of Common Stock were outstanding and 315,518 shares remained reserved for
grants of options under the plan.
    
 
    The 1992  Stock Option  Plan  authorizes the  Board  of Directors  to  issue
options  intended to qualify as incentive  stock options ("ISOs"), as defined in
Section 422A of the Internal Revenue Code of 1986, as amended (the "Code"),  and
stock  options that are not intended to conform to the requirements of such Code
section ("non-qualified options").  The exercise price  of each ISO  may not  be
less  than the fair market value of the  Common Stock at the time of grant, and,
in the case of a grant  to an employee who owns  10% or more of the  outstanding
voting stock of the Company (a "10% Stockholder"), the exercise price may not be
less than 110% of the fair market value on the date of grant. The exercise price
of  each non-qualified option  granted under the  plan may not  be less than the
fair market value  of the Common  Stock on  the date of  grant. Options  granted
under  the plan may not  be exercised after the  tenth anniversary (or the fifth
anniversary in the  case of an  option granted  to a 10%  Stockholder) of  their
grant.
 
                              CERTAIN TRANSACTIONS
 
    The  Company paid consulting  fees to Dr.  Paul A. Brown,  a director of the
Company, for consultation  on business and  scientific matters totaling  $36,000
for each of 1993, 1994 and 1995.
 
   
    In  October 1993, in connection with  the private placement of approximately
$1.0 million aggregate principal amount of 8% convertible promissory notes,  the
Company  sold an aggregate principal  amount of approximately $412,000, $89,000,
$100,000, $104,000, $71,000 and $121,000 of such notes to affiliates of  Dillon,
Read  & Co.,  affiliates of  Gateway Associates,  ML Oklahoma  Venture Partners,
Limited Partnership, Advent  International Group, WestMed  Venture Partners  and
The  Woodlands Venture  Fund, L.P., respectively,  each of which  is a principal
stockholder of the Company. Don  E. Spyrison, a director  of the Company, is  an
affiliate  of The Woodlands Venture Fund, L.P. Joe D. Tippens, a director of the
Company, is a limited partner  of the general partner,  and a consultant to  the
management company, of ML Oklahoma Venture Partners, Limited Partnership.
    
 
    In  March  and April  1994, the  Company  sold at  $4.30 per  share 490,092,
 58,592,  24,092,  21,458, 61,086 and 75,283 shares of Series D Preferred  Stock
to  affiliates  of Dillon,  Read &  Co.,  The Woodlands  Venture Fund,  L.P., ML
Oklahoma  Venture   Partners,  Limited   Partnership,  affiliates   of   Gateway
Associates,   Advent   International   Group  and   WestMed   Venture  Partners,
respectively, each of which  is a principal stockholder  of the Company. Don  E.
Spyrison,  a director of the  Company, is an affiliate  of The Woodlands Venture
Fund, L.P. Joe D. Tippens,  a director of the Company,  is a limited partner  of
the  general partner, and a consultant to the management company, of ML Oklahoma
Venture Partners, Limited Partnership.
 
    In June 1995, the Company sold at $5.00 per share 270,130,  60,000,   45,000
and  200,000 shares of  Series E or  EG Preferred Stock  and related warrants to
purchase at $5.00 per share  an aggregate of 164,664  shares of Common Stock  to
affiliates  of Dillon, Read  & Co., an affiliate  of Gateway Associates, WestMed
Venture Partners and Kummell Investments Limited, respectively, each of which is
a principal stockholder of the Company.
 
                                       41
<PAGE>
          SECURITY OWNERSHIP OF MANAGEMENT AND PRINCIPAL STOCKHOLDERS
 
   
    The following table sets forth information  as of May 10, 1996 (adjusted  to
give  effect to the automatic conversion  of all outstanding shares of Preferred
Stock, Class A Stock and  Class B Stock into  Common Stock immediately prior  to
the  closing of the Offering), and as adjusted to reflect the sale of the Common
Stock  offered  pursuant  to   the  Offering  (assuming   no  exercise  of   the
Underwriters'  over-allotment option), with respect  to the beneficial ownership
of Common Stock by each person known  by the Company to be the beneficial  owner
of  more than 5% of the outstanding shares of Common Stock, by each director and
executive officer of the Company and by all directors and executive officers  of
the Company as a group.
    
 
   
<TABLE>
<CAPTION>
                                                                                       BENEFICIAL OWNERSHIP (1)
                                                                                 -------------------------------------
                                                                                               PRIOR TO       AFTER
                               BENEFICIAL OWNER                                   SHARES(2)    OFFERING     OFFERING
- -------------------------------------------------------------------------------  -----------  -----------  -----------
<S>                                                                              <C>          <C>          <C>
Concord Partners II, L.P. and related entities (3).............................    2,387,208        35.8%        25.2%
The Woodlands Venture Fund, L.P. (4)...........................................      536,148         8.1          5.7
  Martin P. Sutter (4).........................................................      536,148         8.1          5.7
Kummell Investments Limited (5)................................................      530,698         8.0          5.6
ML Oklahoma Venture Partners, Limited Partnership (6)..........................      509,174         7.7          5.4
Advent International Group (7).................................................      438,931         6.7          4.7
Gateway Associates affiliates (8)..............................................      437,335         6.6          4.6
WestMed Venture Partners (9)...................................................      410,977         6.2          4.4
Paul A. Brown, M.D.............................................................      --           --           --
Herbert J. Conrad (10).........................................................        6,250       *            *
Michael E. Herbert (11)........................................................        3,125       *            *
Louis M. Sherwood, M.D. (12)...................................................        6,250       *            *
Don E. Spyrison (4)............................................................      548,648         8.3          5.8
Joe D. Tippens (6).............................................................      509,174         7.7          5.4
William A. Hagstrom (13).......................................................      277,279         4.2          2.9
Socrates H. Choumbakos (14)....................................................      109,080         1.6          1.2
Mark G. Dimitroff (15).........................................................      101,734         1.6          1.1
Robert W. Veltri, Ph.D. (16)...................................................      100,414         1.5          1.1
All executive officers and directors as a group
 (12 persons) (17).............................................................    1,682,704        24.6         17.5
</TABLE>
    
 
- --------------------------
*   Less than 1%.
 
(1) Unless  otherwise noted, the Company believes  that each person named in the
    table has  sole voting  and  investment power  with  respect to  all  shares
    beneficially owned by such person.
 
(2) Each  beneficial owner's percentage ownership is determined by assuming that
    options, warrants and  other convertible  securities that are  held by  such
    person  (but not  those held  by any  other person)  and are  exercisable or
    convertible within 60  days have been  exercised or converted.  A person  is
    deemed to be the beneficial owner of securities that can be acquired by such
    person within 60 days upon the exercise of options or warrants or conversion
    of  convertible securities.  Percentage of  ownership is  based on 6,565,248
    shares of Common Stock outstanding before the Offering and 9,365,248  shares
    of Common Stock outstanding after the Offering.
 
(3) Includes  1,680,528 shares held by Concord  Partners II, L.P., which include
    86,527 shares issuable upon the exercise of certain stock purchase warrants,
    and 369,700 shares held  by Concord Partners  Japan, Limited, which  include
    5,170  shares issuable upon the exercise of certain stock purchase warrants,
    each of which is a  private venture capital fund  managed by Dillon, Read  &
    Co.  Inc. ("Dillon  Read"). Also  includes 28,290  shares held  by Lexington
    Partners III, L.P., and 13,143 shares  held by Lexington Partners IV,  L.P.,
    which  include  800  shares  issuable upon  the  exercise  of  certain stock
    purchase warrants, each of which is  a private investment fund, for  certain
    Dillon  Read affiliated persons, managed by  Dillon Read, and 295,547 shares
    held by Dillon Read as agent for certain affiliated persons of which  13,226
    shares  are issuable upon  the exercise of  certain stock purchase warrants.
    The address of such beneficial owners  is 535 Madison Avenue, New York,  New
    York 10022.
 
                                       42
<PAGE>
(4) The Woodlands Venture Partners, L.P. is the general partner of The Woodlands
    Venture  Fund, L.P.  Martin P.  Sutter and Don  E. Spyrison  are the general
    partners  of  The  Woodlands  Venture   Partners,  L.P.  Because  of   these
    relationships,  The Woodlands Venture  Partners, L.P., Martin  P. Sutter and
    Don E. Spyrison may  be deemed to  be the beneficial  owners of the  536,148
    shares held by The Woodlands Venture Fund, L.P. set forth in the table. Such
    shares  include an aggregate of 39,244  shares of Common Stock issuable upon
    exercise of certain  stock purchase  warrants. Messrs.  Sutter and  Spyrison
    disclaim such beneficial ownership. The address of such beneficial owners is
    2170 Buckthorne Place, Suite 170, The Woodlands, Texas 77380.
 
(5) The  beneficial owner's shares set forth  in the table include 40,000 shares
    of Common Stock issuable upon  exercise of certain stock purchase  warrants.
    The  address of  such beneficial owner  is Suite 922  C, Europort, Gibraltar
    (via London).
 
(6) The beneficial owner's shares set forth  in the table include 12,539  shares
    of  Common  Stock  issuable  upon the  exercise  of  certain  stock purchase
    warrants. The address of such beneficial owner is Meridian Tower, 5100  East
    Skelly  Drive, Suite 1060,  Tulsa, Oklahoma 74135. Mr.  Tippens is a limited
    partner of  the general  partner of  ML Oklahoma  Venture Partners,  Limited
    Partnership  ("ML Oklahoma"), and a consultant  to MLVC Inc., the management
    company to ML Oklahoma, and may be deemed to be the beneficial owner of  the
    509,174  shares held  by ML  Oklahoma set  forth in  the table.  Mr. Tippens
    disclaims beneficial ownership of such shares.
 
(7) The affiliates of Advent International Group  whose shares are set forth  in
    the   table  include   Rovent  Limited   Partnership,  Advent  International
    Technology Fund Limited Partnership, Advent International Investors  Limited
    Partnership,  Advent Omnibus Limited Partnership and Advent S.B.P.E. Limited
    Partnership. Such shares  include an  aggregate of 34,688  shares of  Common
    Stock  issuable upon  the exercise of  certain stock  purchase warrants. The
    address of such beneficial owners is 101 Federal Street, 5th Floor,  Boston,
    Massachusetts 02110.
 
(8) The affiliates of Gateway Associates whose shares are set forth in the table
    include  Gateway Venture  Partners II, L.P.  and Gateway  Partners L.P. Such
    shares include an aggregate of 47,168  shares of Common Stock issuable  upon
    the  exercise  of  certain  stock purchase  warrants.  The  address  of such
    beneficial owners is 8000 Maryland  Avenue, Suite 1190, St. Louis,  Missouri
    63105.
 
(9) The beneficial owner's shares set forth in the table include an aggregate of
    25,995  shares of Common  Stock issuable upon the  exercise of certain stock
    purchase warrants.  The address  of  such beneficial  owner is  200  Liberty
    Street, 39th Floor, New York, New York 10281.
 
(10)  The beneficial owner's shares set forth  in the table include 6,250 shares
    of Common Stock issuable upon the exercise of certain stock options.
 
(11) The beneficial owner's shares set  forth in the table include 3,125  shares
    of Common Stock issuable upon the exercise of certain stock options.
 
(12)  The beneficial owner's shares set forth  in the table include 6,250 shares
    of Common Stock issuable upon the exercise of certain stock options.
 
(13) The beneficial owner's shares set forth in the table include 63,987  shares
    of Common Stock issuable upon the exercise of certain stock options.
 
(14)  The beneficial owner's shares set forth in the table include 75,080 shares
    of Common Stock issuable upon the exercise of certain stock options.
 
(15) The beneficial owner's shares set forth in the table include 19,690  shares
    of Common Stock issuable upon the exercise of certain stock options.
 
(16)  The beneficial owner's shares set forth in the table include 26,580 shares
    of Common Stock issuable upon the exercise of certain stock options.
 
(17) See notes  (4), (6) and  (10) through  (16) to this  table. The  beneficial
    owners'  shares  set forth  in this  table include  an aggregate  of 273,495
    shares of Common Stock issuable upon  the exercise of certain stock  options
    and warrants.
 
                                       43
<PAGE>
                          DESCRIPTION OF CAPITAL STOCK
 
    The  following summary of certain provisions  of the capital stock of UroCor
does not purport to be complete and is subject to, and qualified in its entirety
by, the Restated Certificate of Incorporation and the By-laws which are included
as exhibits to the registration statement of which this Prospectus forms a  part
and by the provisions of applicable law.
 
AUTHORIZED AND OUTSTANDING CAPITAL STOCK
 
    The Company has an authorized capitalization of 26,579,759 shares of capital
stock  consisting of  6,000,000 shares  of Preferred  Stock, par  value $.01 per
share ("Preferred Stock"), 20,000,000 shares of Common Stock, 513,093 shares  of
Class  A Stock, par value $.01 per share ("Class A Stock"), and 66,666 shares of
Class B Stock, par  value $.01 per share  ("Class B Stock"). As  of the date  of
this   Prospectus  (and  giving  effect  to  the  automatic  conversion  of  all
outstanding shares of  Preferred Stock,  Class A Stock  and Class  B Stock  into
shares  of  Common Stock  immediately  prior to  the  closing of  the Offering),
6,565,248 shares of  Common Stock  were issued and  outstanding and  held by  50
stockholders of record, and no shares of Preferred Stock, Class A Stock or Class
B  Stock were outstanding. A total of  1,400,000 shares of Common Stock has been
reserved for grants of options under the 1992 Stock Option Plan. As of the  date
hereof,  an  aggregate of  1,487,904 shares  of Common  Stock were  reserved for
issuance upon exercise of options granted  under the 1992 Stock Option Plan  and
for issuance upon exercise of outstanding warrants.
 
    The  holders of the Common  Stock are entitled to one  vote per share in the
election of directors and in all  matters on which stockholders are entitled  or
permitted  to vote. Such holders  are not entitled to  vote cumulatively for the
election of directors. Holders of  Common Stock have no redemption,  conversion,
preemptive  or  other  subscription rights.  In  the event  of  the liquidation,
dissolution or winding up of the  Company, holders of Common Stock are  entitled
to  share ratably in all  of the assets of the  Company remaining, if any, after
satisfaction of the debts  and liabilities of the  Company and the  preferential
rights  of the  holders of  the Preferred Stock,  if any,  then outstanding. The
outstanding shares of Common Stock are,  and the shares of Common Stock  offered
pursuant  to the Offering will be, upon payment therefor as contemplated herein,
validly issued, fully paid and nonassessable.
 
    At present, there  is no  active trading market  for the  Common Stock.  The
Common  Stock has been approved for listing  on the Nasdaq National Market under
the symbol  "UCOR".  See  "Risk  Factors --  Absence  of  Prior  Public  Market;
Determination of Offering Price; Possible Volatility of Stock Price".
 
    Certain  of  the Company's  existing stockholders  have certain  rights with
respect to  the  registration  under  the Securities  Act  of  an  aggregate  of
5,886,601  shares of Common  Stock (the "Registrable  Shares"). In general, such
stockholders may demand  on up to  two occasions that  the Company register  the
sale of their shares of Common Stock. Each holder of Registrable Shares also has
piggy-back registration rights, subject to certain limitations, in the event the
Company proposes to register the sale of any shares of Common Stock or any other
securities  of  the  Company for  its  own account  or  for the  account  of its
stockholders. The Company is obligated to bear all of the expenses in connection
with the registration of the Registrable Shares, except underwriting commissions
and discounts. Any sales  of Registrable Shares will  be subject to the  180-day
lock-up described under "Shares Eligible for Future Sale" and "Underwriting".
 
CERTAIN ANTI-TAKEOVER EFFECTS OF CERTAIN PROVISIONS OF THE RESTATED CERTIFICATE
OF INCORPORATION, BY-LAWS AND DELAWARE GENERAL CORPORATION LAW
 
    The  Restated  Certificate  of  Incorporation  and  By-laws  contain certain
provisions that could  make more  difficult the  acquisition of  the Company  by
means  of  a  tender  or  exchange offer,  a  proxy  contest  or  otherwise. The
description of such provisions set forth below is intended only as a summary and
is qualified  in  its entirety  by  reference  to the  Restated  Certificate  of
Incorporation  and the  By-laws, each  of which  is filed  as an  exhibit to the
Registration Statement of which this Prospectus forms a part. See "Risk  Factors
- -- Control by Existing Stockholders; Possible Anti-Takeover Effects".
 
                                       44
<PAGE>
    CLASSIFIED  BOARD OF DIRECTORS.   The classification  of directors will have
the effect of making it difficult for stockholders to change the composition  of
the  Board of Directors. At least  two annual meetings of stockholders generally
will be required to effect a change  in the majority of the Board of  Directors.
Such  a delay may help  ensure that the Company's  directors, if confronted by a
stockholder attempting to force a proxy  contest, a tender or exchange offer  or
an extraordinary corporate transaction, would have sufficient time to review the
proposal  as well as  any available alternatives  to the proposal  and to act in
what  they  believe  to  be  the   best  interests  of  the  stockholders.   The
classification  provisions will apply  to every election  of directors, however,
regardless of whether  a change  in the composition  of the  Board of  Directors
would  be beneficial to the Company and  its stockholders and whether a majority
of the Company's stockholders believes that such a change would be desirable.
 
    The classification provisions also could  have the effect of discouraging  a
third  party from initiating a proxy contest,  making a tender or exchange offer
or otherwise attempting to  obtain control of the  Company, even though such  an
attempt  might  be  beneficial  to  the  Company  and  its  stockholders.  These
provisions could  thus increase  the likelihood  that incumbent  directors  will
retain   their  positions.  In  addition,   the  classification  provisions  may
discourage accumulations of large blocks of the Common Stock by purchasers whose
objective is to take control of the  Company and remove a majority of the  Board
of  Directors, and thus could  tend to reduce the  likelihood of fluctuations in
the market price  of the Common  Stock that might  result from accumulations  of
large  blocks for such  purpose. Accordingly, stockholders  could be deprived of
certain opportunities to sell  their shares of Common  Stock at a higher  market
price than might otherwise be the case.
 
    PREFERRED  STOCK.  The Restated  Certificate of Incorporation authorizes the
Board of Directors to  establish one or  more series of  Preferred Stock and  to
determine,  with respect to any series of  Preferred Stock, the terms and rights
of such series. The Company believes that the ability of the Board of  Directors
to  issue one or  more series of  Preferred Stock will  provide the Company with
flexibility in structuring  possible future  financing and  acquisitions and  in
meeting other corporate needs that may arise. The authorized shares of Preferred
Stock, as well as shares of Common Stock, will be available for issuance without
further  action by the Company's stockholders, unless such action is required by
applicable laws or the rules of any stock exchange or automated quotation system
on which the Company's securities may be listed or traded.
 
    Although the Board  of Directors  has no intention  at the  present time  of
doing  so, it could issue  a series of Preferred  Stock that could, depending on
the terms of such  series, impede the  completion of a  merger, tender offer  or
other  takeover attempt. The  Board of Directors will  make any determination to
issue such shares based on its judgment as to the best interests of the  Company
and  its  stockholders.  The  Board  of Directors,  in  so  acting,  could issue
Preferred Stock  having  terms  that could  discourage  an  acquisition  attempt
through which an acquiror may be otherwise able to change the composition of the
Board  of Directors, including  a tender or exchange  offer or other transaction
that some, or a majority, of the  Company's stockholders might believe to be  in
their  best interests or in which stockholders might receive a premium for their
stock over the then current market price of such stock.
 
    SPECIAL MEETING OF STOCKHOLDERS.  The By-laws provide that special  meetings
of  stockholders may be called only by  the President or the Board of Directors.
Such provisions,  together with  the  other anti-takeover  provisions  described
herein, also could have the effect of discouraging a third party from initiating
a  proxy contest, making a  tender or exchange offer  or otherwise attempting to
obtain control of the Company.
 
    NOTICE PROCEDURES.    The  By-laws  provide  that  stockholder  election  of
directors may be conducted only at annual meetings of stockholders and establish
advance  notice procedures with regard to  stockholder proposals relating to the
nomination of candidates for election as director. These procedures provide that
notice of such  stockholder proposals  must be timely  given in  writing to  the
Secretary  of the Company prior to the  annual meeting. Generally, to be timely,
notice must be received  at the principal executive  offices of the Company  not
less  than 60 days nor more than 90  days prior to an annual meeting. The notice
must contain certain information specified in the By-laws.
 
                                       45
<PAGE>
    DELAWARE ANTI-TAKEOVER  LAW.   Under  Section 203  of the  Delaware  General
Corporation   Law   (the  "Delaware   anti-takeover  law"),   certain  "business
combinations" between a Delaware corporation  whose stock generally is  publicly
traded  or held  of record  by more than  2,000 stockholders  and an "interested
stockholder" are prohibited for a three-year period following the date that such
stockholder became an  interested stockholder,  unless (i)  the corporation  has
elected  in its certificate of incorporation or bylaws not to be governed by the
Delaware anti-takeover law  (the Company has  not made such  an election),  (ii)
either  the  business  combination  or  the  transaction  that  resulted  in the
stockholder becoming  an interested  stockholder was  approved by  the board  of
directors  of the corporation before the other party to the business combination
became an interested  stockholder, (iii)  upon consummation  of the  transaction
that  made it  an interested  stockholder, the  interested stockholder  owned at
least 85% of the voting stock of the corporation outstanding at the commencement
of the  transaction (excluding  voting stock  owned by  directors who  are  also
officers  or held in employee  stock plans in which the  employees do not have a
right to determine confidentially  whether to tender or  vote stock held by  the
plan),  or  (iv)  on  or  subsequent  to  the  date  the  stockholder  became an
"interested stockholder", the business combination was approved by the board  of
directors  of the corporation and ratified by  66 2/3% of the voting stock which
the interested  stockholder did  not own.  The three-year  prohibition does  not
apply  to certain  business combinations  proposed by  an interested stockholder
following the announcement or notification of certain extraordinary transactions
involving  the  corporation  and  a  person  who  had  not  been  an  interested
stockholder  during  the  previous  three  years  or  who  became  an interested
stockholder with the approval of a majority of the corporation's directors.  The
term   "business  combination"  is  defined  generally  to  include  mergers  or
consolidations between  a Delaware  corporation and  an interested  stockholder,
transactions with an interested stockholder involving the assets or stock of the
corporation  or its majority-owned subsidiaries  and transactions which increase
an interested stockholder's percentage ownership of stock. The term  "interested
stockholder"  is defined generally  as a stockholder  who becomes the beneficial
owner of 15% or more of a Delaware corporation's voting stock. Section 203 could
have the effect of delaying, deferring or preventing a change in control of  the
Company.
 
LIMITATION ON DIRECTORS' LIABILITY AND INDEMNIFICATION OF DIRECTORS AND OFFICERS
 
    The  Restated Certificate of  Incorporation provides that  a director of the
Company shall not be  personally liable to the  Company or its stockholders  for
monetary  damages  for  breach  of  fiduciary duty  as  a  director,  except for
liability (i) for any breach of the director's duty of loyalty to the Company or
its stockholders, (ii) for acts or omissions not in good faith or which  involve
intentional misconduct or a knowing violation of law, (iii) under Section 174 of
the  Delaware General Corporation Law or (iv) for any transaction from which the
director derived  an  improper personal  benefit.  The Company  is  required  to
indemnify  any director who,  as the result of  his acting as  a director of the
Company, was  or  is a  party  or  is threatened  to  be  made a  party  to  any
threatened,  pending or contemplated action,  suit or proceeding, whether civil,
criminal, administrative  or  investigative, to  the  full extent  permitted  by
Delaware law.
 
    Insofar  as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers  and controlling persons of the  Company
pursuant to the foregoing provisions, or otherwise, the Company has been advised
that   in  the   opinion  of  the   Securities  and   Exchange  Commission  such
indemnification is against public policy as expressed in the Securities Act  and
is, therefore, unenforceable.
 
TRANSFER AGENT AND REGISTRAR
 
    The  transfer agent  and registrar  for the  Common Stock  is American Stock
Transfer & Trust Company, New York, New York.
 
                                       46
<PAGE>
                        SHARES ELIGIBLE FOR FUTURE SALE
 
    Prior to the Offering, there has been no public market for the Common Stock,
and no prediction can be made as to the effect, if any, that the sale of  shares
or  the availability  of shares for  sale will have  on the market  price of the
Common Stock prevailing from  time to time.  Nevertheless, sales of  substantial
amounts  of Common Stock in the  public market could adversely affect prevailing
market prices and  the ability of  the Company  to raise equity  capital in  the
future. See "Underwriting".
 
    Upon  consummation  of  the  Offering,  the  Company  will  have outstanding
9,365,248 shares  of Common  Stock (assuming  no exercise  of the  Underwriters'
over-allotment  option).  The  2,800,000 shares  of  Common Stock  sold  in this
Offering will be freely tradeable  within the public market without  restriction
or  further  registration  under  the  Securities  Act,  except  for  any shares
purchased by "affiliates" of the  Company, as that term  is defined in Rule  144
("Rule  144")  promulgated under  the  Securities Act.  The  remaining 6,565,248
outstanding shares  of Common  Stock are  deemed to  be "restricted  securities"
within  the meaning of  Rule 144 and  may be publicly  resold only if registered
under the Securities Act or sold  in accordance with an eligible exemption  from
registration, such as Rule 144.
 
    The  Company, its executive officers  and directors and certain stockholders
of the Company have agreed that, for a period of 180 days after the date of this
Prospectus, they  will not,  directly or  indirectly, offer,  sell, contract  to
sell,  grant any option to sell or otherwise dispose of, directly or indirectly,
any shares of Common Stock or  securities convertible into or exchangeable  for,
or  any rights to purchase  or acquire, Common Stock,  without the prior written
consent of Montgomery Securities. Montgomery Securities, in its sole  discretion
and at any time without notice, may release all or any portion of the securities
subject to the 180-day lock-up agreement.
 
    Of the 6,565,248 shares of Common Stock held by existing stockholders of the
Company,  (i)  approximately 214,000  will be  eligible for  sale in  the public
market immediately following the Offering  and (ii) an additional  approximately
5,506,000  shares will be  eligible for resale in  the public market immediately
following the  expiration  of the  180-day  lock-up described  above,  of  which
approximately   1,539,000  shares  are  subject  to  certain  volume  and  other
restrictions under Rule 144.
 
    The 6,565,248  shares of  Common Stock  originally issued  and sold  by  the
Company  in private transactions  in reliance upon  exemptions from registration
under the  Securities Act  and held  by stockholders  upon consummation  of  the
Offering are "restricted securities" as that term is defined in Rule 144 and may
be  sold in the public market only  if registered or if exempt from registration
under the Securities Act.
 
    In general, under  Rule 144  as currently in  effect, a  person (or  persons
whose  shares  are required  to be  aggregated), including  an affiliate  of the
Company, who beneficially owns "restricted securities" acquired from the Company
or an affiliate of the Company at least two years prior to the sale is  entitled
to  sell within any three-month period the number of shares that does not exceed
the  greater  of  (i)  1%  of  the  then  outstanding  shares  of  Common  Stock
(approximately   93,652  shares  based  on  the  number  of  shares  outstanding
immediately upon  completion  of  the  Offering, assuming  no  exercise  of  the
Underwriters'  over-allotment  option)  and  (ii)  the  average  weekly reported
trading volume of the  Common Stock during the  four calendar weeks  immediately
preceding the date on which notice of such sale is filed with the Securities and
Exchange Commission (the "Commission"), provided that certain manner of sale and
notice  requirements  and  requirements  as to  availability  of  current public
information concerning the Company are  satisfied (which requirements as to  the
availability  of  current  public  information  are  expected  to  be  satisfied
commencing 90 days  after the  date of this  Prospectus). Under  Rule 144(k),  a
person  who has  not been  an affiliate for  the Company  for a  period of three
months preceding a  sale of securities  by him, and  who beneficially owns  such
"restricted securities" acquired from the Company or an affiliate of the Company
at  least three years prior to such sale,  would be entitled to sell such shares
without regard to  volume limitations, manner  of sale provisions,  notification
requirements   or  requirements  as  to   the  availability  of  current  public
information concerning the Company. Shares held by persons who are deemed to  be
affiliates  of the Company,  including any shares acquired  by affiliates in the
Offering, are subject  to such  volume limitations, manner  of sale  provisions,
 
                                       47
<PAGE>
notification  requirements and requirements as to availability of current public
information concerning the Company, regardless of how long the shares have  been
owned  or how they were  acquired and, in addition,  the sale of any "restricted
securities" beneficially owned by affiliates is subject to the two-year  holding
period  requirement. As defined  in Rule 144,  an "affiliate" of  an issuer is a
person that directly or indirectly through the use of one or more intermediaries
controls, or is controlled by or is under common control with, such issuer.
 
    Any employee,  officer or  director of,  or consultant  to the  Company  who
purchased  his or her shares pursuant to a written compensatory plan or contract
is entitled  to  rely  on  the  resale provisions  of  Rule  701,  which  permit
non-affiliates  to sell their Rule 701  shares without complying with the public
information, holding period, volume limitation or notice provisions of Rule 144,
and which permit affiliates to sell their Rule 701 shares without complying with
the Rule 144 holding period restrictions, in each case commencing 90 days  after
the date of this Prospectus.
 
    The  Company intends to file a registration  statement on Form S-8 under the
Securities Act to register  shares of Common Stock  reserved for issuance  under
the  1992  Stock Option  Plan,  thus permitting  the  resale of  such  shares by
non-affiliates in the  public market without  restrictions under the  Securities
Act.  Such registration statement is expected  to become effective shortly after
the expiration of the 180-day  lock-up described above. As  of the date of  this
Prospectus,   options  to  purchase  1,001,594   shares  of  Common  Stock  were
outstanding, of which options  to purchase 358,180 shares  of Common Stock  were
vested. Of those vested, 239,430 shares are subject to the 180-day lock-up, and,
therefore,  118,750 shares of Common Stock will  be available for sale after the
effective date of the  registration statement on Form  S-8 upon the exercise  of
options.
 
    As  of the  date of  this Prospectus, warrants  to purchase  an aggregate of
486,310 shares of  Common Stock were  outstanding, of which  344,734 shares  are
subject to the 180-day lock-up.
 
    See  "Description of Capital Stock" for information regarding certain rights
to require the Company to register shares of Common Stock.
 
                                       48
<PAGE>
                                  UNDERWRITING
 
    The Underwriters  named  below,  represented by  Montgomery  Securities  and
Volpe,  Welty & Company (the  "Representatives"), have severally agreed, subject
to the terms and conditions set forth in the Underwriting Agreement, to purchase
from the Company the number of  shares of Common Stock indicated below  opposite
their   respective  names  at  the  initial   public  offering  price  less  the
underwriting discount  set forth  on  the cover  page  of this  Prospectus.  The
Underwriting  Agreement provides  that the  obligations of  the Underwriters are
subject to certain conditions precedent, and that the Underwriters are committed
to purchase all of the shares if they purchase any.
 
<TABLE>
<CAPTION>
                                                                                    NUMBER OF
UNDERWRITER                                                                          SHARES
- ---------------------------------------------------------------------------------  -----------
<S>                                                                                <C>
Montgomery Securities............................................................
Volpe, Welty & Company...........................................................
 
                                                                                   -----------
    Total........................................................................    2,800,000
                                                                                   -----------
                                                                                   -----------
</TABLE>
 
    The Representatives have advised the  Company that the Underwriters  propose
initially  to offer the Common Stock to the public on the terms set forth on the
cover page of this Prospectus. The Underwriters may allow to selected dealers  a
concession  of not more than $    per share; and the Underwriters may allow, and
such dealers may  reallow, a  concession of  not more than  $      per share  to
certain  other dealers. After the Offering, the offering price and other selling
terms may be changed by the Representatives. The Common Stock is offered subject
to receipt and acceptance by the Underwriters, and to certain other  conditions,
including the right to reject orders in whole or in part.
 
    The  Company has granted  an option to  the Underwriters, exercisable during
the 30-day period after the date of this Prospectus, to purchase up to a maximum
of 420,000 additional shares of Common  Stock to cover over-allotments, if  any,
at  the  same price  per share  as the  initial  shares to  be purchased  by the
Underwriters. To  the extent  that the  Underwriters exercise  this option,  the
Underwriters  will be committed, subject to certain conditions, to purchase such
additional shares in approximately the same proportion as set forth in the above
table. The Underwriters may purchase  such shares only to cover  over-allotments
made in connection with the Offering.
 
    The  Underwriting  Agreement provides  that the  Company will  indemnify the
Underwriters against certain liabilities, including civil liabilities under  the
Securities  Act, or will contribute to payments the Underwriters may be required
to make in respect thereof.
 
    The  Company,  its  directors  and  executive  officers  and  certain  other
stockholders  of the Company have agreed that for a period of 180 days after the
date of this  Prospectus, they will  not, directly or  indirectly, offer,  sell,
contract  to sell, grant any option to sell or otherwise dispose of, directly or
indirectly, any  shares  of  Common  Stock or  securities  convertible  into  or
exchangeable for, or any rights to purchase or acquire, Common Stock without the
prior  written consent of  Montgomery Securities. Montgomery  Securities may, in
its sole discretion and  at any time  without prior notice,  release all or  any
portion of the shares of Common Stock subject to the lock-up agreements.
 
    In  August  1995,  UroCor  paid Montgomery  Securities  $75,000  for certain
financial advisory services.
 
    The Representatives have informed the  Company that the Underwriters do  not
expect to make sales of Common Stock offered by this Prospectus to accounts over
which they exercise discretionary authority in excess of 5% of the Offering.
 
                                       49
<PAGE>
    Prior to the Offering, there has been no public market for the Common Stock.
Consequently,   the  initial  public  offering   price  will  be  determined  by
negotiations between the Company and  the Representatives. Among the factors  to
be  considered in such  negotiations will be  the history of,  and the prospects
for, the Company and  the industry in  which it competes,  an assessment of  the
Company's  management, the Company's  past and present  operations, its past and
present earnings  and the  trend  of such  earnings,  the prospects  for  future
earnings  of the  Company, the present  state of the  Company's development, the
general condition of the securities markets at the time of the Offering and  the
market  price  of and  demand for  publicly-traded  common stocks  of comparable
companies in recent periods. The  estimated initial public offering price  range
set  forth on the cover page of this Prospectus is subject to change as a result
of market conditions and other factors.
 
    The Common Stock has been approved for listing on the Nasdaq National Market
under the symbol "UCOR".
 
                                 LEGAL MATTERS
 
    The legality of  the Common  Stock offered hereby  will be  passed upon  for
UroCor by Fulbright & Jaworski L.L.P., Houston, Texas. Certain legal matters for
the Underwriters will be passed upon by Cooley Godward Castro Huddleson & Tatum,
Menlo Park, California.
 
                                    EXPERTS
 
    The  financial  statements  and schedule  of  the Company  included  in this
Prospectus and  elsewhere in  the Registration  Statement have  been audited  by
Arthur  Andersen  LLP, independent  public  accountants, as  indicated  in their
reports with  respect thereto  and  are included  herein  in reliance  upon  the
authority  of said  firm as  experts in accounting  and auditing  in giving said
reports.
 
                             AVAILABLE INFORMATION
 
    UroCor has filed with  the Commission a Registration  Statement on Form  S-1
(the  "Registration Statement")  under the  Securities Act  with respect  to the
Common Stock offered by  this Prospectus. This  Prospectus, which constitutes  a
part  of the  Registration Statement,  does not  contain all  of the information
contained in  the  Registration Statement  and  in the  exhibits  and  schedules
thereto,  certain portions of  which are omitted  as permitted by  the rules and
regulations of  the Commission.  For  further information  with respect  to  the
Company  and the Common Stock  offered by this Prospectus,  reference is made to
the Registration Statement, including the exhibits thereto. Statements contained
in this Prospectus as to the contents of any contract or other document filed as
an exhibit to the  Registration Statement are not  necessarily complete, and  in
each  instance reference is  hereby made to  the copy of  such contract or other
documents filed  as an  exhibit to  the Registration  Statement, each  statement
being qualified in all respects by such reference.
 
    The  Registration Statement  and the exhibits  and schedules  thereto may be
inspected, without charge, and copies may be obtained at prescribed rates at the
Public Reference Section of  the Commission at Room  1024, Judiciary Plaza,  450
Fifth  Street, N.W., Washington, D.C. 20549, and  at the regional offices of the
Commission at Northwestern Atrium Center,  500 West Madison Street, 14th  Floor,
Chicago,  Illinois 60661 and Seven World Trade Center, 13th Floor, New York, New
York 10048.
 
    Prior to  the  Offering,  UroCor  has not  been  subject  to  the  reporting
requirements  of the  Securities Exchange Act  of 1934, as  amended. The Company
intends to  furnish  its stockholders  with  annual reports  containing  audited
financial statements reported on by independent public accountants following the
end  of each  fiscal year  and such interim  reports as  it may  determine to be
necessary or desirable.
 
                                       50
<PAGE>
                              FINANCIAL STATEMENTS
                         INDEX TO FINANCIAL STATEMENTS
 
<TABLE>
<CAPTION>
                                                                                                                PAGE
                                                                                                                -----
 
<S>                                                                                                          <C>
Report of Independent Public Accountants...................................................................         F-2
 
Balance Sheets.............................................................................................         F-3
 
Statements of Operations...................................................................................         F-4
 
Statements of Stockholders' Equity.........................................................................         F-5
 
Statements of Cash Flows...................................................................................         F-6
 
Notes to Financial Statements..............................................................................         F-7
</TABLE>
 
                                      F-1
<PAGE>
                    REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS
 
To the Board of Directors of
UroCor, Inc.:
 
    We  have audited the accompanying balance sheets of UroCor, Inc. (a Delaware
corporation) as of  December 31, 1994  and 1995, and  the related statements  of
operations,  stockholders' equity and cash flows for  each of the three years in
the  period  ended  December  31,  1995.  These  financial  statements  are  the
responsibility  of the Company's management. Our responsibility is to express an
opinion on these financial statements based on our audits.
 
    We conducted  our  audits in  accordance  with generally  accepted  auditing
standards.  Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement. An audit includes examining, on a test basis, evidence  supporting
the  amounts and disclosures in the financial statements. An audit also includes
assessing the  accounting  principles used  and  significant estimates  made  by
management,  as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.
 
    In our opinion, the financial  statements referred to above present  fairly,
in  all material respects, the financial position of UroCor, Inc. as of December
31, 1994 and 1995, and the results of its operations and its cash flows for each
of the three  years in the  period ended  December 31, 1995  in conformity  with
generally accepted accounting principles.
 
Oklahoma City, Oklahoma                   ARTHUR ANDERSEN LLP
March 29, 1996
 
                                      F-2
<PAGE>
                                  UROCOR, INC.
                                 BALANCE SHEETS
                                     ASSETS
<TABLE>
<CAPTION>
                                                                                                          MARCH 31,
                                                                                                        --------------
                                                                                                             1995
                                                                                 DECEMBER 31,           --------------
                                                                        ------------------------------
                                                                             1994            1995        (UNAUDITED)
                                                                        --------------  --------------
<S>                                                                     <C>             <C>             <C>
CURRENT ASSETS:
  Cash and cash equivalents...........................................  $    1,822,924  $    3,125,296  $    1,459,589
  Accounts receivable, net of allowance for doubtful accounts of
   $670,845 and $982,046 at December 31, 1994 and 1995 and $756,163
   and $822,044 at March 31, 1995 and 1996............................       2,460,109       4,405,100       3,008,235
  Prepaid expenses....................................................         279,048         421,648         330,868
  Laboratory supplies, at average cost................................         323,333         234,145         254,491
  Other current assets................................................          39,961         119,862          63,314
                                                                        --------------  --------------  --------------
    Total current assets..............................................       4,925,375       8,306,051       5,116,497
                                                                        --------------  --------------  --------------
PROPERTY AND EQUIPMENT, net...........................................       1,967,039       2,443,737       1,892,351
INTANGIBLE AND OTHER ASSETS, net......................................       1,053,749       1,743,722       1,034,742
                                                                        --------------  --------------  --------------
    Total assets......................................................  $    7,946,163  $   12,493,510  $    8,043,590
                                                                        --------------  --------------  --------------
                                                                        --------------  --------------  --------------
                                 LIABILITIES AND STOCKHOLDERS' EQUITY
CURRENT LIABILITIES:
  Accounts payable....................................................         386,482         487,731         296,314
  Accrued compensation................................................         684,814         873,590         568,474
  Other accrued liabilities...........................................         337,839         180,620         313,031
  Current installments of obligations under capital leases............         605,330         860,088         650,028
                                                                        --------------  --------------  --------------
    Total current liabilities.........................................       2,014,465       2,402,029       1,827,847
COMMITMENTS AND CONTINGENCIES (Note 7)................................        --              --              --
LINE OF CREDIT........................................................       1,000,000         700,000       1,250,000
OBLIGATIONS UNDER CAPITAL LEASES, net of current installments.........       1,063,004         966,485         996,833
                                                                        --------------  --------------  --------------
    Total liabilities.................................................       4,077,469       4,068,514       4,074,680
                                                                        --------------  --------------  --------------
STOCKHOLDERS' EQUITY:
  Convertible preferred stock, $.01 par value -- authorized 9,177,357
   shares at December 31, 1994 and March 31, 1995, 10,132,791 shares
   at December 31, 1995 and 6,000,000 shares at March 31, 1996 issued
   in series; 4,883,075 shares outstanding at December 31, 1994 and
   March 31, 1995 and 5,706,395 shares outstanding at December 31,
   1995 and March 31, 1996............................................          48,831          57,064          48,831
  Class A stock, $.01 par value -- authorized 590,674 shares in 1994
   and 1995 and 513,093 shares at March 31, 1996; 513,093 shares
   issued and outstanding.............................................           5,131           5,131           5,131
  Class B stock, $.01 par value -- authorized, issued and outstanding
   66,666 shares......................................................             667             667             667
  Common stock, $.01 par value, authorized 8,000,000 shares at
   December 31, 1994 and March 31, 1995, 8,700,000 shares at December
   31, 1995 and 20,000,000 shares at March 31, 1996; no shares issued
   and outstanding in 1994; 69,188 issued and outstanding at December
   31, 1995 and 22,687 and 81,688 issued and outstanding at March 31,
   1995 and 1996......................................................        --                   692             227
  Additional paid-in capital..........................................      18,701,314      22,716,005      18,709,028
  Accumulated deficit.................................................     (14,887,249)    (14,354,563)    (14,794,974)
                                                                        --------------  --------------  --------------
    Total stockholders' equity........................................       3,868,694       8,424,996       3,968,910
                                                                        --------------  --------------  --------------
    Total liabilities and stockholders' equity........................  $    7,946,163  $   12,493,510  $    8,043,590
                                                                        --------------  --------------  --------------
                                                                        --------------  --------------  --------------
 
<CAPTION>
 
                                                                             1996
                                                                        --------------
 
<S>                                                                     <C>
CURRENT ASSETS:
  Cash and cash equivalents...........................................  $    1,300,846
  Accounts receivable, net of allowance for doubtful accounts of
   $670,845 and $982,046 at December 31, 1994 and 1995 and $756,163
   and $822,044 at March 31, 1995 and 1996............................       4,981,790
  Prepaid expenses....................................................         619,049
  Laboratory supplies, at average cost................................         422,248
  Other current assets................................................         144,804
                                                                        --------------
    Total current assets..............................................       7,468,737
                                                                        --------------
PROPERTY AND EQUIPMENT, net...........................................       2,727,091
INTANGIBLE AND OTHER ASSETS, net......................................       1,838,442
                                                                        --------------
    Total assets......................................................  $   12,034,270
                                                                        --------------
                                                                        --------------
                                 LIABILITIES AND STOCKHOLDERS' EQUITY
CURRENT LIABILITIES:
  Accounts payable....................................................         425,439
  Accrued compensation................................................         747,667
  Other accrued liabilities...........................................         379,644
  Current installments of obligations under capital leases............         829,622
                                                                        --------------
    Total current liabilities.........................................       2,382,372
COMMITMENTS AND CONTINGENCIES (Note 7)................................        --
LINE OF CREDIT........................................................        --
OBLIGATIONS UNDER CAPITAL LEASES, net of current installments.........         950,238
                                                                        --------------
    Total liabilities.................................................       3,332,610
                                                                        --------------
STOCKHOLDERS' EQUITY:
  Convertible preferred stock, $.01 par value -- authorized 9,177,357
   shares at December 31, 1994 and March 31, 1995, 10,132,791 shares
   at December 31, 1995 and 6,000,000 shares at March 31, 1996 issued
   in series; 4,883,075 shares outstanding at December 31, 1994 and
   March 31, 1995 and 5,706,395 shares outstanding at December 31,
   1995 and March 31, 1996............................................          57,064
  Class A stock, $.01 par value -- authorized 590,674 shares in 1994
   and 1995 and 513,093 shares at March 31, 1996; 513,093 shares
   issued and outstanding.............................................           5,131
  Class B stock, $.01 par value -- authorized, issued and outstanding
   66,666 shares......................................................             667
  Common stock, $.01 par value, authorized 8,000,000 shares at
   December 31, 1994 and March 31, 1995, 8,700,000 shares at December
   31, 1995 and 20,000,000 shares at March 31, 1996; no shares issued
   and outstanding in 1994; 69,188 issued and outstanding at December
   31, 1995 and 22,687 and 81,688 issued and outstanding at March 31,
   1995 and 1996......................................................             817
  Additional paid-in capital..........................................      22,761,905
  Accumulated deficit.................................................     (14,123,924)
                                                                        --------------
    Total stockholders' equity........................................       8,701,660
                                                                        --------------
    Total liabilities and stockholders' equity........................  $   12,034,270
                                                                        --------------
                                                                        --------------
</TABLE>
 
      The accompanying notes are an integral part of these balance sheets.
 
                                      F-3
<PAGE>
                                  UROCOR, INC.
                            STATEMENTS OF OPERATIONS
<TABLE>
<CAPTION>
                                                                                                             THREE MONTHS
                                                                                                                ENDED
                                                                                                              MARCH 31,
                                                                                                             ------------
                                                                                                                 1995
                                                                        YEAR ENDED DECEMBER 31,              ------------
                                                             ----------------------------------------------
                                                                  1993            1994            1995       (UNAUDITED)
                                                             --------------  --------------  --------------
<S>                                                          <C>             <C>             <C>             <C>
REVENUE....................................................  $    9,348,498  $   14,531,008  $   19,758,170  $  4,618,955
                                                             --------------  --------------  --------------  ------------
OPERATING EXPENSES:
  Direct cost of services and products.....................       3,893,380       5,891,487       7,353,676     1,658,302
  Selling, general and administrative expenses.............       6,308,134       8,764,598       9,423,216     2,254,735
  Research and development.................................       1,252,009       1,969,076       2,267,102       558,264
                                                             --------------  --------------  --------------  ------------
    Total operating expenses...............................      11,453,523      16,625,161      19,043,994     4,471,301
                                                             --------------  --------------  --------------  ------------
  Income (loss) from operations............................      (2,105,025)     (2,094,153)        714,176       147,654
OTHER INCOME (EXPENSE):
  Interest income..........................................          45,161         103,992         108,983        15,637
  Interest expense.........................................        (108,549)       (307,239)       (290,473)      (71,018)
                                                             --------------  --------------  --------------  ------------
    Total other income (expense)...........................         (63,388)       (203,247)       (181,490)      (55,381)
                                                             --------------  --------------  --------------  ------------
Income (loss) before income taxes..........................      (2,168,413)     (2,297,400)        532,686        92,273
Income taxes (benefit).....................................        --              --              --             --
                                                             --------------  --------------  --------------  ------------
NET INCOME (LOSS)..........................................  $   (2,168,413) $   (2,297,400) $      532,686  $     92,273
                                                             --------------  --------------  --------------  ------------
                                                             --------------  --------------  --------------  ------------
NET INCOME (LOSS) PER SHARE................................  $         (.41) $         (.38) $          .07  $        .01
                                                             --------------  --------------  --------------  ------------
                                                             --------------  --------------  --------------  ------------
SHARES USED IN COMPUTING NET INCOME (LOSS) PER SHARE.......       5,232,636       6,104,035       7,295,548     6,587,933
                                                             --------------  --------------  --------------  ------------
                                                             --------------  --------------  --------------  ------------
 
<CAPTION>
 
                                                                 1996
                                                             ------------
 
<S>                                                          <C>
REVENUE....................................................  $  5,907,549
                                                             ------------
OPERATING EXPENSES:
  Direct cost of services and products.....................     2,138,043
  Selling, general and administrative expenses.............     2,861,877
  Research and development.................................       643,772
                                                             ------------
    Total operating expenses...............................     5,643,692
                                                             ------------
  Income (loss) from operations............................       263,857
OTHER INCOME (EXPENSE):
  Interest income..........................................        23,288
  Interest expense.........................................       (56,506)
                                                             ------------
    Total other income (expense)...........................       (33,218)
                                                             ------------
Income (loss) before income taxes..........................       230,639
Income taxes (benefit).....................................       --
                                                             ------------
NET INCOME (LOSS)..........................................  $    230,639
                                                             ------------
                                                             ------------
NET INCOME (LOSS) PER SHARE................................  $        .03
                                                             ------------
                                                             ------------
SHARES USED IN COMPUTING NET INCOME (LOSS) PER SHARE.......     7,522,946
                                                             ------------
                                                             ------------
</TABLE>
 
   The accompanying notes are an integral part of these financial statements.
 
                                      F-4
<PAGE>
                                  UROCOR, INC.
                       STATEMENTS OF STOCKHOLDERS' EQUITY
<TABLE>
<CAPTION>
                              CONVERTIBLE PREFERRED
                                      STOCK
                               -- ISSUED IN SERIES        CLASS A STOCK             CLASS B STOCK                COMMON STOCK
                              ----------------------  ----------------------  --------------------------  --------------------------
                               SHARES     PAR VALUE    SHARES     PAR VALUE     SHARES       PAR VALUE      SHARES       PAR VALUE
                              ---------  -----------  ---------  -----------  -----------  -------------  -----------  -------------
<S>                           <C>        <C>          <C>        <C>          <C>          <C>            <C>          <C>
BALANCE AT DECEMBER 31,
 1992.......................  3,728,678   $  37,287     513,093   $   5,131       66,666     $     667        --         $  --
Net loss....................     --          --          --          --           --            --            --            --
                              ---------  -----------  ---------  -----------  -----------        -----    -----------        -----
BALANCE AT DECEMBER 31,
 1993.......................  3,728,678   $  37,287     513,093   $   5,131       66,666     $     667        --         $  --
Stock issuance -- New Series
 D..........................  1,154,397      11,544      --          --           --            --            --            --
Net loss....................     --          --          --          --           --            --            --            --
                              ---------  -----------  ---------  -----------  -----------        -----    -----------        -----
BALANCE AT DECEMBER 31,
 1994.......................  4,883,075   $  48,831     513,093   $   5,131       66,666     $     667        --         $  --
Stock issuance -- New Series
 E/EG.......................    823,320       8,233      --          --           --            --            --            --
Exercise of stock options...     --          --          --          --           --            --            69,188           692
Net income..................     --          --          --          --           --            --            --            --
                              ---------  -----------  ---------  -----------  -----------        -----    -----------        -----
BALANCE AT DECEMBER 31,
 1995.......................  5,706,395   $  57,064     513,093   $   5,131       66,666     $     667        69,188     $     692
Exercise of stock options
 (unaudited)................     --          --          --          --           --            --            12,500           125
Stock option -- compensation
 expense (unaudited)........     --          --          --          --           --            --            --            --
Net income (unaudited)......     --          --          --          --           --            --            --            --
                              ---------  -----------  ---------  -----------  -----------        -----    -----------        -----
BALANCE AT MARCH 31, 1996
 (unaudited)................  5,706,395   $  57,064     513,093   $   5,131       66,666     $     667        81,688     $     817
                              ---------  -----------  ---------  -----------  -----------        -----    -----------        -----
                              ---------  -----------  ---------  -----------  -----------        -----    -----------        -----
 
<CAPTION>
 
                              ADDITIONAL                      TOTAL
                                PAID-IN     ACCUMULATED   STOCKHOLDERS'
                                CAPITAL       DEFICIT        EQUITY
                              -----------  -------------  -------------
<S>                           <C>          <C>            <C>
BALANCE AT DECEMBER 31,
 1992.......................  $13,913,988   $(10,421,436)  $ 3,535,637
Net loss....................      --         (2,168,413)    (2,168,413)
                              -----------  -------------  -------------
BALANCE AT DECEMBER 31,
 1993.......................  $13,913,988   $(12,589,849)  $ 1,367,224
Stock issuance -- New Series
 D..........................    4,787,326       --           4,798,870
Net loss....................      --         (2,297,400)    (2,297,400)
                              -----------  -------------  -------------
BALANCE AT DECEMBER 31,
 1994.......................  $18,701,314   $(14,887,249)  $ 3,868,694
Stock issuance -- New Series
 E/EG.......................    3,989,567       --           3,997,800
Exercise of stock options...       25,124       --              25,816
Net income..................      --            532,686        532,686
                              -----------  -------------  -------------
BALANCE AT DECEMBER 31,
 1995.......................  $22,716,005   $(14,354,563)  $ 8,424,996
Exercise of stock options
 (unaudited)................       12,375       --              12,500
Stock option -- compensation
 expense (unaudited)........       33,525       --              33,525
Net income (unaudited)......      --            230,639        230,639
                              -----------  -------------  -------------
BALANCE AT MARCH 31, 1996
 (unaudited)................  $22,761,905   $(14,123,924)  $ 8,701,660
                              -----------  -------------  -------------
                              -----------  -------------  -------------
</TABLE>
 
   The accompanying notes are an integral part of these financial statements.
 
                                      F-5
<PAGE>
                                  UROCOR, INC.
 
                            STATEMENTS OF CASH FLOWS
 
   
<TABLE>
<CAPTION>
                                                                                                             THREE MONTHS ENDED
                                                                      YEAR ENDED DECEMBER 31,                    MARCH 31,
                                                            -------------------------------------------  --------------------------
                                                                1993           1994           1995           1995          1996
                                                            -------------  -------------  -------------  ------------  ------------
                                                                                                                (UNAUDITED)
<S>                                                         <C>            <C>            <C>            <C>           <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
  Net income (loss).......................................  $  (2,168,413) $  (2,297,400) $     532,686  $     92,273  $    230,639
  Adjustments to reconcile net income (loss) to net cash
   used in operating activities:
    Depreciation and amortization.........................        417,966        681,261        875,557       208,689       251,742
    Stock option compensation expense.....................       --             --             --             --             33,525
    Conversion of accrued interest on convertible
     promissory notes.....................................       --               37,333       --             --            --
    Other.................................................          4,892          5,789          4,480          (296)       (2,121)
    Changes in assets and liabilities:
      Increase in accounts receivable, net................       (634,251)      (744,191)    (1,944,991)     (548,126)     (576,690)
      Increase in prepaid expenses........................       (154,168)       (77,745)      (142,600)      (51,820)     (197,401)
      (Increase) decrease in laboratory supplies..........        (33,949)      (216,097)        89,188        68,842      (188,103)
      Increase in other current assets....................         (1,549)       (37,761)       (79,901)      (23,353)      (24,942)
      Increase (decrease) in accounts payable.............        106,593         46,031        101,249       (90,168)      (62,292)
      Increase (decrease) in accrued compensation.........        225,535         14,735        188,776      (116,340)     (125,923)
      Increase (decrease) in other accrued liabilities....        (62,586)       151,548       (157,219)      (24,808)      199,024
                                                            -------------  -------------  -------------  ------------  ------------
      Net cash used in operating activities...............     (2,299,930)    (2,436,497)      (532,775)     (485,107)     (462,542)
                                                            -------------  -------------  -------------  ------------  ------------
CASH FLOWS FROM INVESTING ACTIVITIES:
  Capital expenditures....................................     (1,621,944)      (987,261)    (1,362,599)     (125,764)     (535,509)
  Proceeds from capital leases............................      1,552,155        700,065        845,238       126,193       171,031
  Intangible and other assets.............................        (78,382)      (923,181)      (692,973)       19,007       (94,720)
                                                            -------------  -------------  -------------  ------------  ------------
      Net cash used in investing activities...............       (148,171)    (1,210,377)    (1,210,334)       19,436      (459,198)
                                                            -------------  -------------  -------------  ------------  ------------
CASH FLOWS FROM FINANCING ACTIVITIES:
  Net proceeds from stock issuances.......................       --            3,734,076      3,997,800       --            --
  Exercise of stock options...............................       --             --               25,816       --             12,500
  Proceeds from short-term debt...........................        273,591       --             --             --            --
  Principal payments under capital lease obligations and
   other indebtedness.....................................       (673,714)      (456,991)      (678,135)     (147,664)     (215,210)
  Proceeds from line of credit............................       --            1,000,000      1,200,000       250,000       --
  Payments on line of credit..............................       --             --           (1,500,000)      --           (700,000)
  Net proceeds from sale of convertible notes.............      1,038,607       --             --             --            --
                                                            -------------  -------------  -------------  ------------  ------------
      Net cash provided by (used in) financing
       activities.........................................        638,484      4,277,085      3,045,481       102,336      (902,710)
                                                            -------------  -------------  -------------  ------------  ------------
      Net increase (decrease) in cash and cash
       equivalents........................................     (1,809,617)       630,211      1,302,372      (363,335)   (1,824,450)
CASH AND CASH EQUIVALENTS, beginning
 of period................................................      3,002,330      1,192,713      1,822,924     1,822,924     3,125,296
                                                            -------------  -------------  -------------  ------------  ------------
CASH AND CASH EQUIVALENTS, end of period..................  $   1,192,713  $   1,822,924  $   3,125,296  $  1,459,589  $  1,300,846
                                                            -------------  -------------  -------------  ------------  ------------
                                                            -------------  -------------  -------------  ------------  ------------
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:
  Cash paid for interest..................................  $      75,997  $     237,620  $     262,896  $     61,699  $     50,013
  Cash paid for income taxes..............................       --             --        $      18,000  $    --       $      6,000
SUPPLEMENTAL SCHEDULE OF NONCASH INVESTING AND FINANCING ACTIVITIES:
1993 -- Return of laboratory equipment in the amount of $152,500, included in accounts receivable.
1994 -- Conversion of convertible promissory notes into Series D Preferred Stock in the amount of
        $1,075,940, including accrued interest.
</TABLE>
    
 
   The accompanying notes are an integral part of these financial statements.
 
                                      F-6
<PAGE>
                                  UROCOR, INC.
                         NOTES TO FINANCIAL STATEMENTS
 
1.  THE COMPANY:
    UroCor,  Inc.  ("the  Company"),  a Delaware  corporation,  operates  in one
business segment  and  provides a  broad  range of  diagnostic  and  information
services  and expects to provide therapeutic  products to urologists and managed
care organizations across the U.S. The  Company assists its customers to  better
manage patients with urological cancers and other complex urological diseases.
 
2.  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES:
    (A)  USE OF  ESTIMATES.   The preparation  of these  financial statements in
conformity with generally accepted accounting principles requires management  to
make estimates and assumptions that affect the amounts reported in the financial
statements  and  accompanying  notes.  Actual results  could  differ  from those
estimates.
 
    (B) CASH AND CASH FLOW REPORTING.   The Company considers all highly  liquid
debt  instruments purchased with a  maturity of three months  or less to be cash
equivalents. The fair value of such  instruments equals their net book value  at
December 31, 1995.
 
    (C)  PROPERTY AND  EQUIPMENT.   Property and  equipment are  stated at cost.
Equipment under capital leases is stated  at the present value of minimum  lease
payments at the inception of the lease.
 
    Depreciation  on property and  equipment is calculated  on the straight-line
basis over  the estimated  useful  lives of  the  assets. Equipment  held  under
capital  leases and  leasehold improvements  are amortized  on the straight-line
basis over the shorter of the remaining  lease term or the economic useful  life
of the asset.
 
    In  1995, the Financial Accounting Standards  Board issued Statement No. 121
"Accounting for the Impairment of Long-Lived Assets and for Long-Lived Assets to
be disposed of".  The Company adopted  the standard  in 1995 with  no impact  on
their financial position or results of operations.
 
    (D)  SOFTWARE DEVELOPMENT COSTS.  Certain internal costs related to software
development relating to  the Company's information  services are capitalized  as
property  and equipment  when incurred.  Capitalization begins  when the project
reaches technological  feasibility and  ceases  when the  product is  ready  for
release. Amortization of capitalized software development costs is provided over
the  estimated economic  life of  the software,  generally two  years, using the
straight-line method.  Software  development  costs are  reviewed  annually  for
impairment.  Software development costs  capitalized during 1993,  1994 and 1995
were $0, $0  and $35,000, respectively.  Capitalized software development  costs
capitalized in the three months ended March 31, 1996, were $57,501 (unaudited).
 
    (E)  INTANGIBLE AND OTHER ASSETS.   The Company has  acquired or applied for
options, licenses, patents  and distribution rights  for various diagnostic  and
therapeutic  technologies  or products.  The costs  related  to such  rights are
capitalized and  included in  intangible and  other assets  in the  accompanying
balance sheets. Such costs are amortized over the estimated economic life of the
related technologies or products.
 
   
    (F)     RESEARCH  AND  DEVELOPMENT.    The  Company  conducts  research  and
development activities internally and also engages scientists and clinicians  at
major  academic and research institutions to conduct certain product development
and clinical evaluation work for specific diagnostic products and  technologies.
Contracts  covering  external research  specify periodic  payment terms  and the
nature of the work required,  and in some cases may  extend for a year or  more.
Internal  research and development costs are  expensed as incurred, and external
research and development contract costs are recognized ratably over the contract
period. At  December  31,  1995,  the Company  had  commitments  under  external
research  contracts totaling  approximately $453,900  for 1996  and $175,000 for
1997.
    
 
                                      F-7
<PAGE>
                                  UROCOR, INC.
                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)
 
2.  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES: (CONTINUED)
    (G) INCOME TAXES.  The Company accounts for income taxes under Statement  of
Financial  Accounting Standards ("SFAS") No.  109 "Accounting for Income Taxes".
Under the provisions of SFAS No. 109, deferred income taxes are recorded,  where
appropriate,  to reflect the estimated future tax effects of differences between
financial statement and tax bases of assets and liabilities.
 
    (H) REVENUE.  Revenue is recognized  when products are sold or services  are
rendered.  Revenue subject to Medicare or third-party reimbursement are recorded
at estimated reimbursable amounts. The Company receives a significant portion of
its revenues from tests performed principally for beneficiaries of the  Medicare
program.  In 1993, 1994 and 1995,  approximately 56%, 58% and 58%, respectively,
of the  Company's revenues  were derived  from tests  performed principally  for
beneficiaries of the Medicare program. For the three months ended March 31, 1995
and  1996,  approximately 57%  and 53%  of the  Company's revenues  were derived
similarly from the Medicare program  (unaudited). Under law and regulation,  for
most  of the tests performed for Medicare beneficiaries, the Company must accept
reimbursement allowed by Medicare as payment  in full. Substantially all of  the
Company's  current  services  receive reimbursement  at  various rates  or  on a
case-by-case basis. The Company is not aware of any material claims, disputes or
unresolved matters relating to Medicare or other third-party payors.
 
    (I)  NET INCOME (LOSS) PER COMMON  SHARE AND COMMON SHARE EQUIVALENTS.   Net
income  (loss) per common  share and common share  equivalents has been computed
based upon  the  weighted average  number  of  common shares  and  common  share
equivalents  outstanding during each period.  Common share equivalents recognize
the potential dilutive effects  of the conversion of  preferred stock to  common
stock and the impact of outstanding options and warrants to acquire common stock
using  the treasury stock method and the Company's estimate of the fair value of
common stock at  each year  end. Pursuant  to the  rules of  the Securities  and
Exchange  Commission, common and common share equivalent shares issued in the 12
months prior to March 29, 1996, have been included in the computation of  common
and  common  equivalent  shares as  if  they  were outstanding  for  all periods
presented, including loss years  where the impact of  the incremental shares  is
antidilutive.  All other  common stock equivalents  have been  excluded from the
computations for 1993 and 1994 because their impact on the Company's net  income
(loss) per share is antidilutive.
 
   
    (J)    ACCRUED COMPENSATION.    Accrued compensation  consists  of quarterly
commissions for  sales representatives  (usually paid  the month  following  the
quarter's  end), bonus accruals  for non-sales personnel  (usually paid annually
during the second quarter), and reccurring monthly accruals.
    
 
    (K)  UNAUDITED  INTERIM  FINANCIAL  INFORMATION.    The  unaudited   interim
financial  information as of  March 31, 1995  and 1996 and  for the three months
then ended  has  been  prepared on  the  same  basis as  the  audited  financial
statements.  In the opinion  of management, such  unaudited information includes
all adjustments  (consisting  only  of  normal  recurring  accruals)  considered
necessary for a fair presentation of this interim information. Operating results
for  the three months ended March 31, 1996 are not necessarily indicative of the
results that may be expected  for any other interim  period or any other  future
fiscal year.
 
                                      F-8
<PAGE>
                                  UROCOR, INC.
                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)
 
3.  PROPERTY AND EQUIPMENT:
    Property and equipment, stated at cost, are summarized as follows:
 
<TABLE>
<CAPTION>
                                                              1994            1995
                                                         --------------  --------------  MARCH 31, 1996
                                                                                         ---------------
                                                                                           (UNAUDITED)
<S>                                                      <C>             <C>             <C>
Laboratory equipment...................................  $    1,298,069  $    1,606,846   $   1,683,883
Computer equipment and software........................       1,119,937       1,586,961       1,914,857
Office furniture, equipment and improvements...........         721,452       1,064,970       1,186,711
                                                         --------------  --------------  ---------------
                                                              3,139,458       4,258,777       4,785,451
Less -- Accumulated depreciation and amortization......      (1,172,419)     (1,815,040)     (2,058,360)
                                                         --------------  --------------  ---------------
                                                         $    1,967,039  $    2,443,737   $   2,727,091
                                                         --------------  --------------  ---------------
                                                         --------------  --------------  ---------------
</TABLE>
 
    The depreciable lives for property and equipment are as follows:
 
<TABLE>
<CAPTION>
                                                                                                YEARS
                                                                                             -----------
<S>                                                                                          <C>
Laboratory equipment.......................................................................  3.5 to 5
Computer equipment and software............................................................  3.5 to 5
Office furniture, equipment and improvements...............................................  3.5 to 10
</TABLE>
 
4.  INTANGIBLE AND OTHER ASSETS:
    Intangible and other assets consist of the following:
 
<TABLE>
<CAPTION>
                                                              1994           1995
                                                          -------------  -------------  MARCH 31, 1996
                                                                                        ---------------
                                                                                          (UNAUDITED)
<S>                                                       <C>            <C>            <C>
Licenses, options, patents and trademarks...............  $     166,069  $     320,026   $     331,056
Less -- Accumulated amortization........................       --               (3,000)         (4,250)
                                                          -------------  -------------  ---------------
Net intangible assets...................................        166,069        317,026         326,806
Distribution agreement (Note 7).........................        750,000      1,250,000       1,250,000
Deposits and other......................................        137,680        176,696         261,636
                                                          -------------  -------------  ---------------
                                                          $   1,053,749  $   1,743,722   $   1,838,442
                                                          -------------  -------------  ---------------
                                                          -------------  -------------  ---------------
</TABLE>
 
5.  LINE OF CREDIT:
   
    In March 1994, the Company obtained a $1.5 million line of credit secured by
accounts  receivable and  a lien  on all  other tangible  assets, which excludes
equipment under capital leases, of the Company. The total amount outstanding  on
the  line of credit was  $700,000 at December 31, 1995,  which is reflected as a
non-current liability  in  the  accompanying balance  sheets.  Average  balances
outstanding  under this line of credit  have been $1,000,000 and $882,000 during
1994 and 1995, with  an average interest rate  of 9.2% and 10.58%  respectively.
Interest  is paid monthly at prime (8.75%  at December 31, 1995) plus 1.75%. The
line of credit is due in February 1997 and in 1996 was expanded to $3.0  million
at  an interest rate  of prime plus 1.5%.  The fair value of  the line of credit
equals the net book value at December 31,  1995. Under the terms of the line  of
credit  agreement, the  Company must  comply with  certain restrictive covenants
with which the Company was in compliance at December 31, 1995.
    
 
6.  LEASES:
   
    The Company has used capital lease financing arrangements to acquire certain
equipment. The agreements provide for the  Company to arrange for the  equipment
purchase,  pay the vendor  and receive reimbursement from  the lessor. The lease
payments paid  by the  Company are  generally  for four  years and  provide  for
repayment  of the equipment  cost plus an interest  charge. The Company accounts
    
 
                                      F-9
<PAGE>
                                  UROCOR, INC.
                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)
 
6.  LEASES: (CONTINUED)
   
for these arrangements as capital leases with the capital lease asset  amortized
over the lease term. At December 31, 1994 and 1995, the gross amount of property
and  equipment and  related amortization  recorded under  capital leases  was as
follows:
    
 
<TABLE>
<CAPTION>
                                                              1994            1995
                                                          -------------  --------------  MARCH 31, 1996
                                                                                         --------------
                                                                                          (UNAUDITED)
<S>                                                       <C>            <C>             <C>
Laboratory equipment....................................  $   1,129,587  $    1,490,575   $  1,534,684
Computer equipment......................................        655,305         913,639        927,392
Office furniture and equipment..........................        296,268         629,304        742,623
                                                          -------------  --------------  --------------
                                                              2,081,160       3,033,518      3,204,699
Less -- Accumulated depreciation and amortization.......       (621,396)     (1,337,647)    (1,548,896)
                                                          -------------  --------------  --------------
                                                          $   1,459,764  $    1,695,871   $  1,655,803
                                                          -------------  --------------  --------------
                                                          -------------  --------------  --------------
</TABLE>
 
    The  Company  also  has   noncancelable  operating  leases  for   laboratory
facilities, office space and equipment that expire over the next ten years, with
options  to extend.  Rental expense for  operating leases during  1993, 1994 and
1995 approximated $157,000, $236,000 and $352,000, respectively.
 
    Future minimum lease commitments as of December 31, 1995 are:
 
<TABLE>
<CAPTION>
                                                                               CAPITAL       OPERATING
                                                                               LEASES         LEASES
                                                                            -------------  -------------
<S>                                                                         <C>            <C>
1996......................................................................  $   1,015,400  $     455,477
1997......................................................................        594,894        490,504
1998......................................................................        352,107        529,235
1999......................................................................        133,124        587,018
2000......................................................................       --              624,518
Thereafter (laboratory and office space to 2005)..........................       --            3,497,814
                                                                            -------------  -------------
Total minimum lease payments..............................................      2,095,525  $   6,184,566
                                                                                           -------------
                                                                                           -------------
Less -- Amount representing interest......................................       (268,952)
                                                                            -------------
Total obligations under capital leases....................................      1,826,573
Less -- Current installments of obligations under capital leases..........       (860,088)
                                                                            -------------
Obligation under capital leases, net of current installments..............  $     966,485
                                                                            -------------
                                                                            -------------
</TABLE>
 
    In June  1995, the  Company consolidated  all of  its operations,  research,
marketing  and administrative functions  into a new  building constructed by and
leased from a shareholder of  the Company. The Company's  10 year lease on  this
facility   covers  48,000  square  feet  initially  with  options  available  on
additional space  up to  the entire  110,000 square  feet of  the building.  The
monthly rentals are included in the operating lease commitments above.
 
    In  March 1996,  the Company  received a commitment  for a  new $1.5 million
lease financing arrangement for capital expenditures through March 1997.
 
7.  COMMITMENTS AND CONTINGENCIES:
   
    (A) DISTRIBUTION  AGREEMENT.   In  connection  with a  product  distribution
agreement,  which grants  the Company exclusive  marketing rights  in the United
States, covering a therapeutic product  for bladder cancer currently  undergoing
regulatory  review by the U.S. Food and Drug Administration ("FDA"), the Company
made payments  to a  manufacturer of  $750,000 and  $500,000 in  1994 and  1995,
respectively.
    
 
                                      F-10
<PAGE>
                                  UROCOR, INC.
                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)
 
7.  COMMITMENTS AND CONTINGENCIES: (CONTINUED)
These payments, totaling $1,250,000 are included in intangible and other assets,
net  in the accompanying balance sheets at  December 31, 1994 and 1995 (see Note
4). The Company will be required to make a milestone payment of $1,750,000  when
and  if  regulatory approval  by  the FDA  is received.  If  the product  is not
approved by the FDA within a specified time period, the manufacturer must  repay
the Company an amount equivalent to all amounts previously paid by the Company.
 
   
    The  aggregate  payments of  $3.0 million  to be  paid under  the agreement,
assuming FDA  approval, will  be  amortized over  the  shorter of  the  expected
economic  life of the  product or the distribution  agreement, based on expected
future unit sales of the product. Assuming  and upon approval of the product  by
the  FDA, the Company will be required to conduct specified sales, marketing and
certain other activities with  respect to the product  and meet certain  minimum
unit  sales levels. The initial  term of the distribution  agreement is for five
years, and the Company has an option  to renew for an additional five years,  at
no cost, if the minimum sales levels are attained.
    
 
    (B)  EMPLOYMENT  AGREEMENTS.   Certain  key  employees of  the  Company have
entered into arrangements  regarding their  terms of employment.  While none  of
such  arrangements provide for fixed periods  of employment, they do provide for
continued payment of salaries for up to six months following termination without
cause, aggregating approximately  $378,000 at  December 31, 1995  and March  31,
1996 (unaudited).
 
8.  RELATED PARTY TRANSACTIONS:
    The  Company had certain transactions  for contractual services performed by
members of the  Board of  Directors or their  affiliates which  are included  in
expenses  of approximately $71,000, $59,000 and  $42,000 in 1993, 1994 and 1995,
respectively. In addition, the Company recognized rent expense totaling $167,000
related to the new facility which is leased from a shareholder (see Note 6).  In
management's  opinion, these transactions were  conducted on terms equivalent to
those with unrelated third parties.
 
9.  STOCKHOLDERS' EQUITY:
    CONVERTIBLE PREFERRED STOCK, CLASS A STOCK AND CLASS B STOCK. The  Company's
convertible preferred stock consists of the following:
 
<TABLE>
<S>                                                                                  <C>
1991 Series A, $.01 par value, authorized, issued and outstanding 1,199,999 shares
Series B, $.01 par value, authorized, issued and outstanding 1,467,608 shares in
 1994 and 1995
Series B1, $.01 par value, authorized 1,467,608 shares; no shares issued and
 outstanding
Series C, $.01 par value, authorized, issued and outstanding 981,071 shares in 1994
 and 1995
Series C1, $.01 par value, authorized 981,071 shares; no shares issued and
 outstanding
Series D, $.01 par value, authorized 1,500,000 shares in 1994 and 1,154,397 shares
 in 1995; issued and outstanding 1,154,397 shares in 1994 and 1995
Series D1, $.01 par value, authorized 1,500,000 shares in 1994 and 1,154,397 shares
 in 1995; no shares issued and outstanding in 1994 and 1995
Series E/EG, $.01 par value, authorized, no shares issued and outstanding in 1994;
 issued and outstanding 823,320 shares in 1995
Series E1/EG1, $.01 par value, authorized 823,320; no shares issued and outstanding
 in 1994 and 1995
Series I, $.01 par value, authorized, issued and outstanding 80,000 shares in 1994
 and 1995
</TABLE>
 
                                      F-11
<PAGE>
                                  UROCOR, INC.
                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)
 
9.  STOCKHOLDERS' EQUITY: (CONTINUED)
    In  March  1996,  the  Company  restated  its  Certificate  of Incorporation
changing the authorized shares of  preferred stock from 10,132,791 to  6,000,000
and the authorized shares of Class A Stock from 590,674 to 513,093.
 
    SERIES D PREFERRED STOCK AND CONVERTIBLE PROMISSORY NOTES.  In October 1993,
several existing stockholders of the Company purchased 8% Convertible Promissory
Notes from the Company resulting in total proceeds to the Company of $1,038,607.
Effective  March 30,  1994, in  connection with  the sale  of 849,094  shares of
Series D Preferred Stock at $4.30 per share, the 8% Convertible Promissory Notes
were converted into 250,224 shares of Series D Preferred Stock. In April 1994, a
secondary closing on sales  of Series D Preferred  Stock was completed with  the
sale of 55,079 shares at $4.30 per share. The aggregate proceeds from the Series
D Preferred Stock offerings totaled $4,963,885, with cash proceeds of $3,887,945
and  $1,075,940  from  conversion of  the  8% Convertible  Promissory  Notes and
related accrued interest, resulting in net proceeds of $4,798,870.
 
    Upon conversion of the 8%  Convertible Promissory Notes as discussed  above,
the  Company agreed to execute and deliver to the 8% Convertible Promissory Note
purchasers stock warrants to  purchase 130,232 shares of  Common Stock at  $4.30
per share, exercisable through October 1998.
 
    SERIES  E AND SERIES EG  PREFERRED STOCK.  In  June 1995, the Company closed
offerings of Series E and Series  EG preferred stock totaling 823,320 shares  at
$5.00  per share. In connection with  this offering, the Company issued warrants
to purchase 164,664 shares of Common Stock  with an exercise price of $5.00  per
share.  These warrants expire after five years. The net proceeds from the Series
E and Series EG preferred stock offering totaled $3,997,800.
 
    The significant attributes of  each class or series  of stock are  described
below:
 
    (A) CONVERSION.
 
        (I)  AUTOMATIC  CONVERSION.    Each  outstanding  share  of  Convertible
    Preferred Stock and Class  A Stock and Class  B Stock will automatically  be
    converted  into  Common Stock  upon the  closing  of an  underwritten public
    offering. In addition, in the event of a liquidation, dissolution, merger or
    sale of the Company, in which the market valuation of the Company equals  or
    exceeds  $46,220,397, all Class A Stock will automatically be converted into
    Common Stock.
 
    In the  event of  a  new stock  offering  at a  per  share price  below  the
respective  conversion price of Series B, Series C, Series D, Series E or Series
EG Preferred Stock,  each share of  Series B, Series  C, Series D,  Series E  or
Series  EG  Preferred Stock  held by  a  party not  participating in  such stock
offering will automatically convert to one share of Series B1, Series C1, Series
D1, Series E1 or Series EG1 Preferred Stock, as applicable.
 
        (II) OPTIONAL CONVERSION.  Convertible Preferred Stock is convertible at
    the option of the holder, at any time, into shares of Common Stock.
 
        (III) CONVERSION  SHARES.   The  per share  conversion factors  will  be
    ratably  adjusted  to reflect  any changes  in capital  stock such  as stock
    dividends, combinations  or reclassifications.  At  December 31,  1995,  all
    Convertible  Preferred  Stock,  Class  A  Stock  and  Class  B  Stock shares
    outstanding were convertible to an equivalent number of Common Stock shares,
    except that the 981,071 shares of Series C Preferred Stock were  convertible
    into 1,177,277 shares of Common Stock.
 
    (B)  LIQUIDATION.   Upon  dissolution below  certain specified  or aggregate
proceeds, liquidation  or sale,  merger  or other  disposition of  the  Company,
stockholders will receive distribution of proceeds as described below:
 
                                      F-12
<PAGE>
                                  UROCOR, INC.
                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)
 
9.  STOCKHOLDERS' EQUITY: (CONTINUED)
        (I)  FIRST PREFERENCE.  Holders of Convertible Preferred Stock and Class
    A Stock will  first receive  preference to Common  Stock and  Class B  Stock
    holders.  The holders of Convertible Preferred  Stock and Class A Stock will
    receive declared but unpaid dividends plus the following amount per share:
 
    - $.25 per share for Class A Stock;
 
    - $1.25 per share for 1991 Series A and Series I Preferred Stock;
 
    - $1.55 per share for Series B and Series B1 Preferred Stock;
 
    - $3.25 per share for Series C and Series C1 Preferred Stock;
 
    - $4.30 per share for Series D and D1 Preferred Stock; and
 
    - $5.00 per  share  for Series  E,  Series E1,  Series  EG, and  Series  EG1
      Preferred.
 
    If  proceeds are insufficient to permit payment in full, as described above,
then the holders of these  shares will share ratably  in proportion to the  full
amounts otherwise distributable.
 
        (II)  SECOND PREFERENCE.  If the  first preference amounts are satisfied
    in full, remaining proceeds will then be distributed to the holders of Class
    A Stock as  follows: the lesser  of (i)  $1,683,396 or (ii)  26% of  amounts
    remaining available for distribution.
 
    If  proceeds are  insufficient to  permit payment  in full  of the secondary
preference amounts,  then the  holders of  these shares  will share  ratably  in
proportion to the full amount otherwise distributable.
 
        (III)  GENERAL  DISTRIBUTION.    Upon satisfying  the  First  and Second
    Preference requirements, all holders of stock will then share ratably in any
    remaining proceeds, on a basis as  if converted to Common Stock. All  shares
    will  convert  to  Common  Stock  except  in  the  event  of  a liquidation,
    dissolution, merger or sale of the Company, in which the market valuation of
    the Company equals or exceeds $46,220,397,  then after the first and  second
    preference   distributions  described  above,  any  holders  of  Convertible
    Preferred Stock would not participate in the general distribution  described
    above. In such a liquidation, dissolution, merger or sale, the Class A Stock
    would  be automatically converted into Common  Stock and therefore would not
    participate in the first and second preferences described above.
 
    (C) REDEMPTION.  All series of convertible preferred stock excluding  Series
EG  and EG1, were originally  issued with redemption rights.  In March 1996, the
shareholders of these convertible preferred shares relinquished their redemption
rights  pursuant  to  the  Company's  plans  for  an  initial  public  offering.
Accordingly  all  convertible preferred  stock is  classified  as equity  in the
accompanying balance sheet at par value.
 
    COMMON STOCK.   At December 31,  1995, the Company  had 8,700,000 shares  of
Common Stock authorized for the conversion of Convertible Preferred Stock, Class
A  Stock, Class B Stock  and the exercise of  Common Stock options and warrants.
The total Common Stock shares that would have been issued assuming conversion of
all series and  classes of  stock and  exercise of  options and  warrants as  of
December  31,  1995  was 8,020,202.  In  March  1996, the  Company  restated its
Certificate of Incorporation changing the authorized shares of Common Stock from
8,700,000 shares to 20,000,000 shares.
 
    WARRANTS.   There  are a  total  of  486,310 warrants  outstanding  for  the
purchase  of the  Company's common stock  exercisable at  prices ranging between
$1.25 to $5.50 per share and expiring from
 
                                      F-13
<PAGE>
                                  UROCOR, INC.
                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)
 
9.  STOCKHOLDERS' EQUITY: (CONTINUED)
October 1998  to  May  2001.  No  value was  attributed  to  these  warrants  in
connection  with their issuances.  At December 31, 1995,  none of these warrants
had been exercised. A summary of the warrants outstanding is presented below:
 
<TABLE>
<CAPTION>
                                                                                                             MARCH 31, 1996
                                   1993                       1994                      1995                  (UNAUDITED)
                        --------------------------  ------------------------  ------------------------  ------------------------
                                       EXERCISE                   EXERCISE                  EXERCISE                  EXERCISE
                                       PRICE PER                  PRICE PER                 PRICE PER                 PRICE PER
                         WARRANTS        SHARE       WARRANTS       SHARE      WARRANTS       SHARE      WARRANTS       SHARE
                        -----------  -------------  -----------  -----------  -----------  -----------  -----------  -----------
<S>                     <C>          <C>            <C>          <C>          <C>          <C>          <C>          <C>
Outstanding, beginning
 of year..............      85,600     $    1.25        85,600   $      1.25     321,646   $1.25 - 5.50    486,310   $1.25 - 5.50
Granted...............      --                         236,046   4.30 - 5.50     164,664          5.00      --           --
Exercised.............      --                          --                        --                        --           --
                        -----------                 -----------               -----------               -----------
Outstanding, end of
 year.................      85,600     $    1.25       321,646   $1.25 - 5.50    486,310   $1.25 - 5.50    486,310   $1.25 - 5.50
                        -----------                 -----------               -----------               -----------
                        -----------                 -----------               -----------               -----------
</TABLE>
 
10. STOCK OPTION PLAN:
    The Company has adopted a stock  option plan, the "1992 Stock Option  Plan".
The  Company accounts  for this plan  under APB  Opinion No. 25,  under which no
compensation cost  has  been  recognized,  except for  the  stock  option  grant
described below. Under the Plan 1,400,000 shares of common stock are reserved as
incentive and non-qualified options for employees and officers and non-qualified
options  for directors and independent contractors of the Company. These options
vest over three  to five  years, expire  ten years  after issuance  and have  an
exercise  price equal to the stock's estimated  fair market value on the date of
grant.
 
    A summary of the status of the plan is presented below:
 
<TABLE>
<CAPTION>
                                                                                                   MARCH 31, 1996
                                 1993                   1994                    1995                (UNAUDITED)
                        ----------------------  ---------------------  ----------------------  ----------------------
                                    EXERCISE                EXERCISE               EXERCISE                EXERCISE
                                    PRICE PER              PRICE PER                 PRICE                   PRICE
                         SHARES       SHARE      SHARES      SHARE      SHARES     PER SHARE    SHARES     PER SHARE
                        ---------  -----------  ---------  ----------  ---------  -----------  ---------  -----------
<S>                     <C>        <C>          <C>        <C>         <C>        <C>          <C>        <C>
Outstanding, beginning
 of period............     80,000   $.35 - .75    284,000  $.35 -  .75   706,994  $.35 - 1.25    982,344  $.35 - 1.75
Granted...............    204,000   .35 - .75     423,494  .75 - 1.25    403,250  1.25 - 1.75     --          --
Exercised.............     --                      --                    (69,188)  .35 -  .75    (12,500)        1.00
Expired...............     --                        (500)        .75    (58,712)  .35 - 1.50    (10,250)  .75 - 1.50
                        ---------               ---------              ---------               ---------
Outstanding, end of
 period...............    284,000   $.35 - .75    706,994  $.35 - 1.25   982,344  $.35 - 1.75    959,594   .35 - 1.75
                        ---------               ---------              ---------               ---------
                        ---------               ---------              ---------               ---------
Exercisable, end of
 period...............     78,990   $.35 - .75    269,320  $.35 - 1.25   341,870  $.35 - 1.75    353,580   .35 - 1.75
                        ---------               ---------              ---------               ---------
                        ---------               ---------              ---------               ---------
</TABLE>
 
    In December 1995, the Company  issued options to employees covering  295,000
shares  of Common Stock.  Considering the Company's  anticipated public offering
price per share and other events,  the Company estimated that the adjusted  fair
value  of the Common  Stock at the date  of grant of  these options exceeded the
exercise price of the options.  Accordingly, the Company will recognize  imputed
compensation   expenses  as   a  noncash   charge  to   operations,  aggregating
approximately $443,000 over the actual vesting period of these options of  three
to five years.
 
    In  1995, the Financial Accounting Standards  Board issued Statement No. 123
"Accounting for  Stock -  Based Compensation".  This Statement  requires  either
changing  accounting methods to recognize the fair value of stock options issued
as compensation expense in the financial statements, or
 
                                      F-14
<PAGE>
                                  UROCOR, INC.
                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)
 
10. STOCK OPTION PLAN: (CONTINUED)
disclosing the  effect  that  such  change  would  have  had  on  the  financial
statements.  The Company will adopt Statement No. 123 in 1996 and has elected to
only provide the disclosures required by  the statement. Thus, there will be  no
effect on the Company's financial position.
 
11. EMPLOYEE BENEFIT PLAN:
    The  Company  has  established  a  401(k)  employee  benefit  plan  covering
substantially all  employees.  The Plan  is  funded through  voluntary  employee
salary  deferrals. Although the Company has the discretion to make contributions
to the Plan, no such amounts have been contributed to date.
 
12. INCOME TAXES:
    The tax effects of the temporary differences which gave rise to deferred tax
assets and liabilities at December 31, 1994 and 1995 were:
 
<TABLE>
<CAPTION>
                                                                                1994           1995
                                                                            -------------  -------------
<S>                                                                         <C>            <C>
Code Section 481 adjustment related to change to accrual method of
 accounting...............................................................  $    (355,022) $    (236,681)
Assets and liabilities related to capitalized leases, net.................         78,236         49,667
Depreciation and amortization.............................................         55,400        (17,889)
Allowance for doubtful accounts...........................................       --             (117,961)
Alternative minimum tax carryforward......................................       --               24,000
Net operating loss........................................................      3,644,867      3,642,906
                                                                            -------------  -------------
Net deferred tax asset (liability)........................................      3,423,481      3,344,042
Valuation allowance.......................................................     (3,423,481)    (3,320,042)
                                                                            -------------  -------------
    Total net deferred tax asset..........................................  $    --        $      24,000
                                                                            -------------  -------------
                                                                            -------------  -------------
</TABLE>
 
    At December  31,  1995, the  Company  had  regular tax  net  operating  loss
carryforwards  of approximately $13,700,000 which will  begin to expire in 2002.
The Company's income tax provision differed from the federal statutory rate  due
to  the utilization  of the Company's  tax net operating  loss carryforward. The
annual utilization of this carryforward will be limited by Internal Revenue Code
Section 382 due to the  fact a cumulative change in  ownership of more than  50%
has previously occurred. Therefore, the future utilization of this net operating
loss carryforward will be limited to approximately $9,600,000.
 
    A  valuation allowance against the net deferred tax asset has been recorded,
except for the amount attributable to  the alternative minimum tax credit  which
can  be carried forward indefinitely, on  the basis that significant uncertainty
exists regarding the  realizability of such  assets. The deferred  tax asset  is
included in other assets in the accompanying balance sheets.
 
                                      F-15
<PAGE>
- -------------------------------------------
                                     -------------------------------------------
- -------------------------------------------
                                     -------------------------------------------
 
    NO  DEALER, SALESPERSON,  OR OTHER  PERSON HAS  BEEN AUTHORIZED  TO GIVE ANY
INFORMATION OR  TO MAKE  ANY REPRESENTATIONS  IN CONNECTION  WITH THIS  OFFERING
OTHER  THAN THOSE  CONTAINED IN  THIS PROSPECTUS,  AND, IF  GIVEN OR  MADE, SUCH
INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON AS HAVING BEEN AUTHORIZED
BY THE COMPANY OR THE UNDERWRITERS. THIS PROSPECTUS DOES NOT CONSTITUTE AN OFFER
TO SELL OR  A SOLICITATION  OF AN  OFFER TO BUY  ANY SECURITIES  OTHER THAN  THE
SHARES OF COMMON STOCK TO WHICH IT RELATES OR AN OFFER TO, OR A SOLICITATION OF,
ANY  PERSON  IN  ANY JURISDICTION  WHERE  SUCH  OFFER OR  SOLICITATION  WOULD BE
UNLAWFUL. NEITHER THE DELIVERY  OF THIS PROSPECTUS NOR  ANY SALE MADE  HEREUNDER
SHALL,  UNDER ANY  CIRCUMSTANCES, CREATE AN  IMPLICATION THAT THERE  HAS BEEN NO
CHANGE IN  THE  AFFAIRS  OF THE  COMPANY  SINCE  THE DATE  HEREOF  OR  THAT  THE
INFORMATION  CONTAINED HEREIN IS CORRECT  AS OF ANY TIME  SUBSEQUENT TO THE DATE
HEREOF.
 
                             ----------------------
 
                               TABLE OF CONTENTS
                             ----------------------
 
<TABLE>
<CAPTION>
                                                    PAGE
                                                    -----
<S>                                              <C>
PROSPECTUS SUMMARY.............................           3
RISK FACTORS...................................           5
THE COMPANY....................................          14
USE OF PROCEEDS................................          14
DIVIDEND POLICY................................          14
CAPITALIZATION.................................          15
DILUTION.......................................          16
SELECTED FINANCIAL DATA........................          17
MANAGEMENT'S DISCUSSION AND ANALYSIS OF
 FINANCIAL CONDITION AND RESULTS OF
 OPERATIONS....................................          18
BUSINESS.......................................          24
MANAGEMENT.....................................          36
CERTAIN TRANSACTIONS...........................          41
SECURITY OWNERSHIP OF MANAGEMENT AND PRINCIPAL
 STOCKHOLDERS..................................          42
DESCRIPTION OF CAPITAL STOCK...................          44
SHARES ELIGIBLE FOR FUTURE SALE................          47
UNDERWRITING...................................          49
LEGAL MATTERS..................................          50
EXPERTS........................................          50
AVAILABLE INFORMATION..........................          50
INDEX TO FINANCIAL STATEMENTS..................         F-1
</TABLE>
 
                             ----------------------
 
    UNTIL                  ,  1996 (25 DAYS AFTER THE DATE OF THIS  PROSPECTUS),
ALL  DEALERS EFFECTING TRANSACTIONS IN THE  COMMON STOCK OFFERED HEREBY, WHETHER
OR NOT  PARTICIPATING  IN  THIS  DISTRIBUTION, MAY  BE  REQUIRED  TO  DELIVER  A
PROSPECTUS.  THIS  DELIVERY  REQUIREMENT IS  IN  ADDITION TO  THE  OBLIGATION OF
DEALERS TO DELIVER A PROSPECTUS WHEN ACTING AS UNDERWRITERS AND WITH RESPECT  TO
THEIR UNSOLD ALLOTMENTS OR SUBSCRIPTIONS.
 
                                2,800,000 SHARES
 
                                     [LOGO]
                                  COMMON STOCK
 
                              -------------------
 
                                   PROSPECTUS
 
                              -------------------
                             MONTGOMERY SECURITIES
 
                             VOLPE, WELTY & COMPANY
                                           , 1996
 
- -------------------------------------------
                                     -------------------------------------------
- -------------------------------------------
                                     -------------------------------------------
<PAGE>
                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS
 
ITEM 13.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.
 
    The estimated expenses in connection with the Offering are:
 
<TABLE>
<S>                                                                        <C>
Securities and Exchange Commission Registration Fee......................  $  11,104
NASD Filing Fee..........................................................      3,720
Nasdaq National Market Listing Fee.......................................     40,000
Legal Fees and Expenses..................................................    200,000
Accounting Fees and Expenses.............................................    100,000
Blue Sky Fees and Expenses (including legal fees)........................     15,000
Printing Expenses........................................................    150,000
Transfer Agent and Registrar Fees........................................      5,000
Miscellaneous............................................................     75,176
                                                                           ---------
  TOTAL..................................................................  $ 600,000
                                                                           ---------
                                                                           ---------
</TABLE>
 
ITEM 14.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.
 
    Article  X of  the Company's  Amended and  Restated By-laws  (the "By-laws")
provides for  mandatory  indemnification to  at  least the  extent  specifically
allowed  by Section 145 of the General  Corporation Law of the State of Delaware
(the "GCL").
 
    Pursuant to  Section 145  of the  GCL,  UroCor generally  has the  power  to
indemnify  its  current and  former  directors, officers,  employees  and agents
against expenses and liabilities incurred by them in connection with any suit to
which they are, or threatened to be made, a party by reason of their serving  in
such  positions  so long  as  they acted  in  good faith  and  in a  manner they
reasonably believed to  be in,  or not  opposed to,  the best  interests of  the
Company,  and with respect to any criminal  action, they had no reasonable cause
to believe their conduct was lawful. With respect to suits by or in the right of
the Company, however,  indemnification is generally  limited to attorneys'  fees
and  other expenses and is not available if such person is adjudged to be liable
to the Company unless the court determines that indemnification is  appropriate.
The statute expressly provides that the power to indemnify authorized thereby is
not  exclusive  of  any  rights  granted under  any  bylaw,  agreement,  vote of
stockholders or disinterested directors, or otherwise. The Company also has  the
power to purchase and maintain insurance for such persons.
 
    The  above discussion of the Company's By-laws and Section 145 of the GCL is
not intended to be exhaustive and is  qualified in its entirety by each of  such
documents and such statute.
 
    The  Company has entered into indemnification agreements with its directors,
executive officers and certain key employees that generally obligate the Company
to indemnify such persons to the extent permitted under the GCL.
 
    Reference is  made to  the  form of  the  Underwriting Agreement,  filed  as
Exhibit   1.1  to  be   filed  by  amendment,   which  contains  provisions  for
indemnification of  the Company,  its directors,  officers and  any  controlling
persons   by  the  Underwriters  against  certain  liabilities  for  information
furnished by the Underwriters.
 
ITEM 15.  RECENT SALES OF UNREGISTERED SECURITIES.
 
    Since January  1,  1993, UroCor  has  sold unregistered  securities  in  the
amounts,  at  the time  and for  the aggregate  amounts of  consideration listed
below. With respect to sales  of Preferred Stock and  Class A stock, all  shares
and  amounts and per share prices described  below have been adjusted to reflect
the automatic conversion of such shares  into Common Stock immediately prior  to
the  closing of  the Offering  and a five-to-one  stock split  effected in March
1993. The securities were sold to  purchasers directly by the Company, and  such
sales did not involve any underwriter. The Company considers these securities to
have  been offered and sold in transactions not involving a public offering and,
therefore, to
 
                                      II-1
<PAGE>
be exempted  from  registration under  Section  4(2)  and Regulation  D  of  the
Securities  Act of 1933, as amended. For  equity securities, the "Type" of stock
listed in the table below reflects the class or series of stock actually issued,
however, the  number  of shares  has  been  adjusted to  reflect  the  automatic
conversion  of such shares into Common Stock immediately prior to the closing of
the Offering.
 
<TABLE>
<CAPTION>
                                                                                    AGGREGATE
                                                                                    AMOUNT OF
                                                                                    SECURITIES      AGGREGATE
             PURCHASER                         TYPE                  DATE             ISSUED      CONSIDERATION
- ------------------------------------  ----------------------  ------------------  --------------  -------------
<S>                                   <C>                     <C>                 <C>             <C>
Investor Group (1)..................     Promissory Notes     October 1993        $  1,038,607     $ 1,038,607
Investor Group (2)..................    Series D Preferred    March/April 1994       1,154,397     $ 4,963,885
Investor Group (1)..................         Warrants         March 1994                      (3)          N/A
Investor Group (4)..................    Series E Preferred    June 1995                763,320     $ 3,816,600
Investor Group (5)..................   Series EG Preferred    June 1995                 60,000     $   300,000
Investor Group (4)(5)...............         Warrants         June 1995                       (6)          N/A
Various Employees and a Director
 Through Exercise of Options Granted                          From January 1993
 Under 1992 Stock Option Plan.......       Common Stock       through April 1996        82,288     $    38,765
Silicon Valley Bank.................         Warrant          April 1994                      (7)          N/A
Bank of Oklahoma....................         Warrant          April 1994                      (8)          N/A
IAF Biovac, Inc.....................         Warrant          December 1994                   (9)          N/A
</TABLE>
 
- --------------------------
(1) The investor group consists of  Concord Partners II, L.P.; Concord  Partners
    Japan  Limited; PB-SB 1985 Investment Partnership VII; The Woodlands Venture
    Fund,  L.P.;  Salomon  Brothers  Holding  Company,  Inc.;  WestMed   Venture
    Partners;  ML Oklahoma  Venture Partners,  Limited Partnership; Presbyterian
    Health  Foundation;   Rovent  Limited   Partnership;  Advent   International
    Investors  Limited Partnership;  Advent Omnibus  Limited Partnership; Advent
    S.B.P.E. Limited  Partnership;  Gateway  Venture Partners  II,  L.P.;  Marco
    Investment  Company;  Floyd E.  Farha; William  M.  and Lu  Beard Charitable
    Remainder Trust; and Stanton L. Young.
 
(2) The investor group consists of  Concord Partners II, L.P.; Concord  Partners
    Japan  Limited; PB-SB 1985 Investment Partnership VII; The Woodlands Venture
    Fund,  L.P.;  Salomon  Brothers  Holding  Company,  Inc.;  WestMed   Venture
    Partners;  ML Oklahoma  Venture Partners,  Limited Partnership; Presbyterian
    Health  Foundation;   Rovent  Limited   Partnership;  Advent   International
    Investors  Limited Partnership;  Advent Omnibus  Limited Partnership; Advent
    S.B.P.E. Limited  Partnership;  Gateway  Venture Partners  II,  L.P.;  Marco
    Investment  Company;  Floyd E.  Farha; William  M.  and Lu  Beard Charitable
    Remainder Trust; Stanton L. Young;  Lexington Partners III, L.P.;  Lexington
    Partners  IV, L.P.; Dillon,  Read & Co. Inc.,  as Agent; Kummell Investments
    Limited; and Dean A. McGee Eye Institute Endowment Fund.
 
(3) The aggregate number of shares of Common Stock issuable upon exercise of the
    warrants is 130,232, subject to certain antidilution adjustments.
 
(4) The investor group consists of GMI/DRI Investment Trust; Dillon, Read &  Co.
    Inc.,  as Agent;  Concord Partners  II, L.P.;  Lexington Partners  IV, L.P.;
    Kummell Investments Limited; WestMed Venture Partners; Smith Barney Inc., as
    custodian for the benefit of Floyd E. Farha IRA Rollover; Floyd E. Farha; W.
    M. and  Lu  Beard  Charitable Remainder  Trust;  Marco  Investment  Company;
    Stanton L. Young; and The Health Care and Biotechnology Fund.
 
(5) The investor group consists of Gateway Partners L.P.
 
(6) The aggregate number of shares of Common Stock issuable upon exercise of the
    warrants is 164,664, subject to certain antidilution adjustments.
 
(7)  The number of shares of Common  Stock issuable upon exercise of the warrant
    is 4,942, subject to certain antidilution adjustments.
 
(8) The number of shares of Common  Stock issuable upon exercise of the  warrant
    is 872, subject to certain antidilution adjustments.
 
(9)  The number of shares of Common  Stock issuable upon exercise of the warrant
    is 100,000, subject to certain antidilution adjustments.
 
                                      II-2
<PAGE>
ITEM 16.  EXHIBITS AND FINANCIAL STATEMENT SCHEDULES.
 
    (a)  Exhibits:
 
   
<TABLE>
<CAPTION>
   NO.                                                         DESCRIPTION
- ---------             ---------------------------------------------------------------------------------------------
<C>        <C>        <S>
    1.1*          --  Form of Underwriting Agreement.
    3.1*          --  Restated Certificate of Incorporation.
    3.2*          --  Amended and Restated By-laws.
    4.1*          --  Form of Common Stock Certificate.
    4.2*          --  See Exhibits numbered 3.1 and 3.2 for provisions of the Restated Certificate of Incorporation
                       and Amended and  Restated By-laws of  UroCor defining the  rights of the  holders of  Common
                       Stock.
    5.1*          --  Opinion of Fulbright & Jaworski L.L.P.
   10.1*          --  The UroCor, Inc. Amended and Restated 1992 Stock Option Plan.
   10.2*          --  Distribution Agreement, dated December 30, 1994, between IAF BioVac Inc. and UroCor, Inc. and
                       letter  agreement  dated  December  30,  1994, between  IAF  BioVac  Inc.  and  UroCor, Inc.
                       (Confidential Treatment requested pursuant to Rule 406 under the Securities Act).
   10.3*          --  Loan Agreement, dated March 14, 1994, between Silicon Valley Bank and CytoDiagnostics,  Inc.,
                       as modified by Loan Modification Agreement dated June 13, 1994 between CytoDiagnostics, Inc.
                       and  Silicon  Valley Bank,  and Loan  Modification  Agreement dated  March 9,  1995, between
                       Silicon Valley  Bank and  UroCor, Inc.  and as  amended by  Amendment to  Loan and  Security
                       Agreement dated February 1, 1996, between Silicon Valley Bank and UroCor, Inc.
   10.4*          --  Lease  Agreement, dated  April 15, 1994,  between Presbyterian Health  Foundation and UroCor,
                       Inc.
   10.5*          --  Employment Agreement, dated January 1, 1990, between William A. Hagstrom and UroCor, Inc.
   10.6*          --  Employment Agreement, dated April 23, 1990, between Mark Dimitroff and UroCor, Inc.
   10.7*          --  Employment Agreement, dated September 4, 1990, between Robert Veltri and UroCor, Inc.
   10.8*          --  Employment Agreement, dated June 1, 1992, between Socrates Choumbakos and UroCor, Inc.
   10.9*          --  Form of Indemnification Agreement between UroCor, Inc.  and each of the individuals named  in
                       Schedule 10.9 thereto.
   10.10*         --  1995 Management Incentive Compensation Plan.
   10.11*         --  Registration  Rights Agreement, dated June  2, 1995, among UroCor,  Inc. and the stockholders
                       named therein.
   10.12*         --  Master Equipment Lease, dated May 17, 1995, between Financing for Science International, Inc.
                       and UroCor, Inc.,  Commitment Letter  dated March 18,  1996, between  Financing for  Science
                       International, Inc. and UroCor, Inc. and Amendment Letter dated April 17, 1996, by Financing
                       for Science International, Inc.
   10.13*         --  Master  Lease Agreement, dated June 26, 1993,  between Linc Capital Management Services, Ltd.
                       and CytoDiagnostics, Inc., as amended  by Addendum No. 001  to Master Lease Agreement  dated
                       June  26, 1993,  between Linc Capital  Management Services, Ltd.  and CytoDiagnostics, Inc.,
                       Addendum No.  002 to  Master  Lease Agreement  dated July  19,  1993, between  Linc  Capital
                       Management  Services,  Ltd. and  CytoDiagnostics,  Inc., Addendum  No.  003 to  Master Lease
                       Agreement dated  October  8,  1993,  between Linc  Capital  Management  Services,  Ltd.  and
                       CytoDiagnostics,  Inc. and  Addendum No.  004 to Master  Lease Agreement  dated December 22,
                       1994, between Linc Capital Management Services, Ltd. and UroCor, Inc.
</TABLE>
    
 
                                      II-3
<PAGE>
   
<TABLE>
<CAPTION>
   NO.                                                         DESCRIPTION
- ---------             ---------------------------------------------------------------------------------------------
   10.14*         --  Employment Agreement, dated April 5, 1996, between Kathryn L.W. Ingerly and UroCor, Inc.
<C>        <C>        <S>
   11.1*          --  Statement re Computation of Per Share Earnings.
   23.1           --  Consent of Arthur Andersen LLP.
   23.2*          --  Consent of Fulbright & Jaworski L.L.P. (included in Exhibit 5.1).
   24.1*          --  Powers of Attorney from certain members of the Board of Directors of the Company.
</TABLE>
    
 
- ------------------------
   
* Previously filed.
    
 
    As permitted by Item 601(b)(4) of Regulation S-K, the Company has not  filed
with  this  Registration Statement  certain instruments  defining the  rights of
holders of long-term debt of  the Company, if any,  because the total amount  of
securities  authorized under any of such instruments  does not exceed 10% of the
total assets of the Company.  The Company agrees to furnish  a copy of any  such
agreements to the Securities and Exchange Commission upon request.
 
    (b) Financial Statement Schedules:
 
        Schedule II -- Valuation and Qualifiying Accounts
 
ITEM 17.  UNDERTAKINGS.
 
    Insofar  as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers  and controlling persons of the  Company
pursuant to the foregoing provisions, or otherwise, the Company has been advised
that   in  the   opinion  of  the   Securities  and   Exchange  Commission  such
indemnification is against public policy as expressed in the Securities Act  and
is,  therefore, unenforceable.  In the  event that  a claim  for indemnification
against such liabilities  (other than  the payment  by the  Company of  expenses
incurred  or paid by a director, officer or controlling person of the Company in
the successful defense of  any action, suit or  proceeding) is asserted by  such
director,  officer or controlling person in connection with the securities being
registered, the Company will,  unless in the opinion  of its counsel the  matter
has  been settled  by controlling  precedent, submit  to a  court of appropriate
jurisdiction the question whether such  indemnification by it is against  public
policy  as expressed  in the Securities  Act and  will be governed  by the final
adjudication of such issue.
 
    The undersigned Company hereby undertakes to provide to the Underwriters  at
the  closing  specified  in  the  Underwriting  Agreement  certificates  in such
denominations and registered in  such names as required  by the Underwriters  to
permit prompt delivery to each purchaser.
 
    The undersigned Company hereby undertakes that:
 
        (1)  For purposes of determining any liability under the Securities Act,
    the information omitted from the form of prospectus filed as a part of  this
    Registration Statement in reliance upon Rule 430A and contained in a form of
    prospectus  filed by the Company pursuant to Rule 424(b)(1) or (4) or 497(h)
    under the Securities Act shall be deemed  to be a part of this  Registration
    Statement as of the time it was declared effective.
 
        (2)  For the purpose  of determining any  liability under the Securities
    Act, each post-effective amendment that contains a form of prospectus  shall
    be  deemed to  be a  new registration  statement relating  to the securities
    offered therein, and the offering of  such securities at that time shall  be
    deemed to be the initial bona fide offering thereof.
 
                                      II-4
<PAGE>
                                   SIGNATURES
 
   
    Pursuant  to the requirements  of the Securities Act,  UroCor, Inc. has duly
caused this Amendment No. 3 to Registration Statement to be signed on its behalf
by the undersigned,  thereunto duly authorized,  in the City  of Oklahoma  City,
State of Oklahoma, on May 16, 1996.
    
 
                                                       UroCor, Inc.
 
                                          By:       /s/ WILLIAM A. HAGSTROM
 
                                            ------------------------------------
                                                    William A. Hagstrom
                                              CHAIRMAN OF THE BOARD, PRESIDENT
                                                AND CHIEF EXECUTIVE OFFICER
 
   
    Pursuant  to the requirements of the Securities Act, this Amendment No. 3 to
Registration Statement has  been signed below  by the following  persons in  the
capacities and on the dates indicated.
    
 
   
<TABLE>
<CAPTION>
                      SIGNATURE                                             TITLE                            DATE
- ------------------------------------------------------  ---------------------------------------------  ----------------
 
<S>                                                     <C>                                            <C>
               /s/ WILLIAM A. HAGSTROM                   Chairman of the Board, President and Chief        May 16, 1996
     -------------------------------------------           Executive Officer (Principal Executive
                 William A. Hagstrom                                      Officer)
 
              /s/ SOCRATES H. CHOUMBAKOS                 Vice President Corporate Development, Chief       May 16, 1996
     -------------------------------------------         Financial Officer and Secretary (Principal
                Socrates H. Choumbakos                               Financial Officer)
 
               /s/ MICHAEL N. MCDONALD                   Director of Finance and Administration and        May 16, 1996
     -------------------------------------------          Treasurer (Principal Accounting Officer)
                 Michael N. McDonald
 
                          *                                               Director                         May 16, 1996
     -------------------------------------------
                 Paul A. Brown, M.D.
 
                          *                                               Director                         May 16, 1996
     -------------------------------------------
                  Herbert J. Conrad
 
                /s/ MICHAEL E. HERBERT                                    Director                         May 16, 1996
     -------------------------------------------
                  Michael E. Herbert
 
                          *                                               Director                         May 16, 1996
     -------------------------------------------
               Louis M. Sherwood, M.D.
 
                       /s/ DON E. SPYRISON                                Director                         May 16, 1996
     -------------------------------------------
                   Don E. Spyrison
 
                          *                                               Director                         May 16, 1996
     -------------------------------------------
                    Joe D. Tippens
 
         *By:      /s/ SOCRATES H. CHOUMBAKOS
        --------------------------------------
 Socrates H. Choumbakos, ATTORNEY-IN-FACT FOR EACH OF
                THE PERSONS INDICATED
</TABLE>
    
 
                                      II-5
<PAGE>
                    REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS
 
To the Board of Directors of
UroCor, Inc.:
 
    We  have audited in  accordance with generally  accepted auditing standards,
the financial statements of UroCor, Inc. included in this registration statement
and have issued our report thereon dated March 29, 1996. Our audit was made  for
the  purpose of forming an opinion on  the basic financial statements taken as a
whole. The schedule listed in the index of financial statements is presented for
purposes of complying with the Securities and Exchange Commission's rules and is
not part of the basic financial statements. This schedule has been subjected  to
the  auditing procedures applied in the  audit of the basic financial statements
and, in our opinion, fairly states  in all material respects the financial  data
required  to be set forth therein in  relation to the basic financial statements
taken as a whole.
 
Oklahoma City, Oklahoma,                  ARTHUR ANDERSEN LLP
March 29, 1996
 
                                      S-1
<PAGE>
                                                                     SCHEDULE II
 
                                  UROCOR, INC.
                       VALUATION AND QUALIFYING ACCOUNTS
 
<TABLE>
<CAPTION>
                                                                         ADDITIONS
                                                                 --------------------------
                                                                  CHARGE TO     CHARGE TO
                                                     BEGINNING    COST AND        OTHER                     ENDING
                   DESCRIPTION                        BALANCE      EXPENSE      ACCOUNTS     DEDUCTION(1)   BALANCE
- --------------------------------------------------  -----------  -----------  -------------  ------------  ---------
<S>                                                 <C>          <C>          <C>            <C>           <C>
For the Year Ended December 31, 1995:
  Allowance for Doubtful Accounts.................     670,845      934,482        --           (623,281)    982,046
 
For the Year Ended December 31, 1994:
  Allowance for Doubtful Accounts.................     392,522      706,074        --           (427,751)    670,845
 
For the Year Ended December 31, 1993:
  Allowance for Doubtful Accounts.................     204,530      496,264        --           (308,272)    392,522
</TABLE>
 
- ------------------------
(1) Represents write-offs  of  uncollectible  accounts  receivable  against  the
    allowance for doubtful accounts.
 
                                      S-2
<PAGE>
                               INDEX TO EXHIBITS
 
   
<TABLE>
<CAPTION>
 EXHIBITS                                                                                                       PAGE
- -----------                                                                                                   ---------
<C>          <S>                                                                                              <C>
      1.1*   Form of Underwriting Agreement.
      3.1*   Restated Certificate of Incorporation.
      3.2*   Amended and Restated By-laws.
      4.1*   Form of Common Stock Certificate.
      4.2*   See Exhibits numbered 3.1 and 3.2 for provisions of the Restated Certificate of Incorporation
              and Amended and Restated By-laws of UroCor defining the rights of the holders of Common Stock.
      5.1*   Opinion of Fulbright & Jaworski L.L.P.
     10.1*   The UroCor, Inc. Amended and Restated 1992 Stock Option Plan.
     10.2*   Distribution Agreement, dated December 30, 1994, between IAF BioVac Inc. and UroCor, Inc. and
              letter agreement dated December 30, 1994, between IAF BioVac Inc. and UroCor, Inc.
              (Confidential Treatment requested pursuant to Rule 406 under the Securities Act).
     10.3*   Loan Agreement, dated March 14, 1994, between Silicon Valley Bank and CytoDiagnostics, Inc., as
              modified by Loan Modification Agreement dated June 13, 1994 between CytoDiagnostics, Inc. and
              Silicon Valley Bank, and Loan Modification Agreement dated March 9, 1995, between Silicon
              Valley Bank and UroCor, Inc., and as amended by Amendment to Loan and Security Agreement dated
              February 1, 1996, between Silicon Valley Bank and UroCor, Inc.
     10.4*   Lease Agreement, dated April 15, 1994, between Presbyterian Health Foundation and UroCor, Inc.
     10.5*   Employment Agreement, dated January 1, 1990, between William A. Hagstrom and UroCor, Inc.
     10.6*   Employment Agreement, dated April 23, 1990, between Mark Dimitroff and UroCor, Inc.
     10.7*   Employment Agreement, dated September 4, 1990, between Robert Veltri and UroCor, Inc.
     10.8*   Employment Agreement, dated June 1, 1992, between Socrates Choumbakos and UroCor, Inc.
     10.9*   Form of Indemnification Agreement between UroCor, Inc. and each of the individuals named in
              Schedule 10.9 thereto.
     10.10*  1995 Management Incentive Compensation Plan.
     10.11*  Registration Rights Agreement, dated June 2, 1995, among UroCor, Inc. and the stockholders
              named therein.
     10.12*  Master Equipment Lease, dated May 17, 1995, between Financing for Science International, Inc.
              and UroCor, Inc., Commitment Letter dated March 18, 1996, between Financing for Science
              International, Inc. and UroCor, Inc. and Amendment Letter dated April 17, 1996, by Financing
              for Science International, Inc.
</TABLE>
    
<PAGE>
   
<TABLE>
<CAPTION>
 EXHIBITS                                                                                                       PAGE
- -----------                                                                                                   ---------
     10.13*  Master Lease Agreement, dated June 26, 1993, between Linc Capital Management Services, Ltd. and
              CytoDiagnostics, Inc., as amended by Addendum No. 001 to Master Lease Agreement dated June 26,
              1993, between Linc Capital Management Services, Ltd. and CytoDiagnostics, Inc., Addendum No.
              002 to Master Lease Agreement dated July 19, 1993, between Linc Capital Management Services,
              Ltd. and CytoDiagnostics, Inc., Addendum No. 003 to Master Lease Agreement dated October 8,
              1993, between Linc Capital Management Services, Ltd. and CytoDiagnostics, Inc. and Addendum
              No. 004 to Master Lease Agreement dated December 22, 1994, between Linc Capital Management
              Services, Ltd. and UroCor, Inc.
<C>          <S>                                                                                              <C>
     10.14*  Employment Agreement, dated April 5, 1996, between Kathryn L.W. Ingerly and UroCor, Inc.
     11.1*   Statement re Computation of Per Share Earnings.
     23.1    Consent of Arthur Andersen LLP.
     23.2*   Consent of Fulbright & Jaworski L.L.P. (included in Exhibit 5.1).
     24.1*   Powers of Attorney from certain members of the Board of Directors of the Company.
</TABLE>
    
 
- ------------------------
   
* Previously filed.
    

<PAGE>
                                                                    EXHIBIT 23.1
 
                   CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS
 
    As  independent  public accountants,  we hereby  consent to  the use  of our
reports and  to  all  references  to our  firm  included  in  this  registration
statement.
 
   
Oklahoma City, Oklahoma                   ARTHUR ANDERSEN LLP
May 16, 1996
    


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