BOSTON LIFE SCIENCES INC /DE
SC 13G/A, 1999-02-16
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                    -----------------------------------------


                                  SCHEDULE 13G
                                (Amendment No. 1)
                    Under the Securities Exchange Act of 1934
                    -----------------------------------------


                           Boston Life Sciences, Inc.
                    -----------------------------------------
                                (Name of Issuer)


                     Common Stock, par value $0.01 per share
                   ------------------------------------------
                         (Title of Class of Securities)

                                    100843408
                                  -------------
                                 (CUSIP Number)

        Check the  appropriate  box to designate the rule pursuant to which this
Schedule is filed:

                                    [ ]   Rule 13d-1(b)
                                    [X]   Rule 13d-1(c)
                                    [ ]   Rule 13d-1(d)

        *The  remainder  of this cover page shall be filled out for a  reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

        The  information  required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see 
the Notes to Schedule 13G).



                                       1

<PAGE>

                                  SCHEDULE 13G

CUSIP No.  100843408                                                 Page 2 of 5
- --------------------------------------------------------------------------------
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

        Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF MEMBER OF A GROUP     (a) |_|       (b) |_|
- --------------------------------------------------------------------------------
3)      SEC USE ONLY
- --------------------------------------------------------------------------------
4)      CITIZENSHIP OR PLACE OF ORGANIZATION
        United States
- --------------------------------------------------------------------------------
                      5)     SOLE VOTING POWER
                             345,504
        NUMBER        ----------------------------------------------------------
        OF            6)     SHARED VOTING POWER
        SHARES               54,052 /1/
        BENEFICIALLY  ----------------------------------------------------------
        OWNED BY      7)     SOLE DISPOSITIVE POWER
        EACH                 345,504 /1/
        REPORTING     ----------------------------------------------------------
        PERSON        8)     SHARED DISPOSITIVE POWER
        WITH                 54,052
- --------------------------------------------------------------------------------
9)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        399,556 /2/
- --------------------------------------------------------------------------------
10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
                                                                             [ ]
- --------------------------------------------------------------------------------
11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
        3.00%
- --------------------------------------------------------------------------------
12)     TYPE OF REPORTING PERSON
        IN
- --------------------------------------------------------------------------------


- -------- 

        1   Includes 27,027 shares of common stock of the Issuer and warrants to
purchase 9,009 shares of common stock of the Issuer held by Aries Domestic Fund,
L.P.  (the  "Partnership")  and 13,512  shares of common stock of the issuer and
warrants  to  purchase  4,504  shares of Common  Stock of the Issuer held by The
Aries Master  Fund,  a Cayman  Island  exempted  company  (the  "Master  Fund").
Paramount Capital Asset Management,  Inc. ("PCAM") is the general partner of the
Partnership and the investment  manager of the Master Fund. Dr. Rosenwald is the
chairman and sole shareholder of PCAM.

        2   Does not include 10,801 shares of common stock of the Issuer held by
Dr.  Rosenwald's wife in trust for the benefit of his minor children,  for which
Dr. Rosenwald disclaims beneficial ownership.



                                        2

<PAGE>

Item 1.

        (a)           Name of Issuer:

                      Boston Life Sciences, Inc. (the "Company")

        (b)           Address of Issuer's Principal Executive Offices:

                      Boston Life Sciences, Inc.
                      31 Newbury Street, Ste. 300
                      Boston, MA 02116

Item 2.

        (a)           Name of Person Filing:

                      Lindsay A. Rosenwald, M.D.

        (b)           Address  of  Principal   Business   Office  or,  if  None,
                      Residence:

                      Paramount Capital
                      787 Seventh Avenue, 48th Floor
                      New York, New York 10019

        (c)           Citizenship:

                      Dr. Rosenwald is a citizen of the United States.

        (d)           Title of Class of Securities:

                      Common Stock, $0.01 par value ("shares").

        (e)           CUSIP#:

                      452525306

Item 3.               Check the box if this  statement is filed pursuant to Rule
                      13d-1(c)  [ ]

Item 4.               Ownership:

                      For  information  concerning the ownership of Common Stock
                      of the  Company  by the  Reporting  Persons,  see  Items 5
                      through 9 and 11 of the cover pages to this  schedule  13G
                      and footnotes thereto.

Item 5.               Ownership of Five Percent or Less of a Class:

                      As of  the  date  of  the  filing  of  this  Schedule  13G
                      Amendment, Dr. Rosenwald ceased to be the beneficial owner
                      of more than 5% of the shares



                                        3

<PAGE>

                      of the Issuer.

Item 6.               Ownership  of More than Five  Percent on Behalf of Another
                      Person:

                      Not applicable.

Item 7.               Identification  and Classification of the Subsidiary Which
                      Acquired  the  Security  Being  Reported  On By the Parent
                      Holding Company:

                      Not applicable.

Item 8.               Identification and Classification of Members of the Group:

                      Not applicable.

Item 9.               Notice of Dissolution of Group:

                      Not applicable.

Item 10.              Certification:

                      By  signing  below  I  certify  that,  to the  best  of my
        knowledge and belief, the securities referred to above were not acquired
        and are not held for the  purpose of or with the effect of  changing  or
        influencing  the  control of the issuer of the  securities  and were not
        acquired and are not held in connection  with or as a participant in any
        transaction having that purpose or effect.



                                       4
<PAGE>

                                    SIGNATURE

        After  reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.



Dated:         February 16, 1999
               New York, NY                 By  /s/ Lindsay A. Rosenwald, M.D.  
                                               ---------------------------------
                                                   Lindsay A. Rosenwald, M.D.


                                              5



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