DEUTSCHE BANK AG\
SC 13G/A, 2000-02-14
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                   -----------------------------------------

                                 SCHEDULE 13G/A

                    Under the Securities Exchange Act of 1934

                                (Amendment No. 2)


                                   Qiagen N.V.
                   -----------------------------------------
                                (Name of issuer)


                                 Ordinary Shares
                   -----------------------------------------
                         (Title of class of securities)


                                   000N724821
                   -----------------------------------------
                                 (CUSIP number)


                               December 31, 1999
                   -----------------------------------------
             (Date of Event which requires filing of this Statement)

         Check the  appropriate box to designate the rule pursuant to which this
schedule is filed:

                                [ ] Rule 13d-1 (b)
                                [X] Rule 13d-1 (c)
                                [ ] Rule 13d-1 (d)





<PAGE>





- ----------------------                                       -------------------
 CUSIP No. 000N724821                  13G                    Page 2 of 6 Pages
- ----------------------                                       -------------------



- -------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Bank A.G.
- -------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) [_]
                                                                       (b) [_]
- -------- -----------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
- ---------------------------- ------ --------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    37,875
                             ------ --------------------------------------------
BENEFICIALLY OWNED BY               SHARED VOTING POWER
                             6      3,228,002
                             ------ --------------------------------------------
EACH REPORTING                      SOLE DISPOSITIVE POWER
                             7      37,875
                             ------ --------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      3,739,915
- -------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         3,777,790
- -------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                    [_]
- -------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         11.2%
- -------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC, BK, CO
- -------- -----------------------------------------------------------------------



<PAGE>


Item 1(a). Name of Issuer:

           Qiagen N.V. (the "Issuer")

Item 1(b). Address of Issuer's Principal Executive Offices:

           The  address of the  Issuer's  principal  executive  office  Johannes
Vermersplain 9-1, Amsterdam, 1071 DV, Netherlands.

Item 2(a). Name of Person Filing:

           This statement is filed on behalf of Deutsche Bank AG (the "Reporting
Person"). This Schedule 13G/A is being filed pursuant to Rule 13d-2(b).

Item 2(b). Address of Principal Business Office or, if none, Residence:

           The  principal  place  of  business  of  the   Reporting   Person  is
Taunusanlage 12, D-60325, Frankfurt am Main, Federal Republic of Germany.

Item 2(c). Citizenship:

           The  citizenship of the  Reporting  Person  is set forth on the cover
page.

Item 2(d). Title of Class of Securities:

           The  title  of  the  securities  is  ordinary  shares (the  "Ordinary
Shares").

Item 2(e). CUSIP Number:

          The CUSIP number of the Ordinary Shares is set forth on the applicable
cover page.

Item 3.   If this  statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or
          (c), check whether the person filing is a:

          (a)  [_] Broker or dealer registered under section 15 of the Act;

          (b)  [_] Bank as defined in section 3(a)(6) of the Act;

          (c)  [_] Insurance Company as defined in section 3(a)(19) of the Act;

          (d)  [_]  Investment   Company  registered  under  section  8  of  the
               Investment Company Act of 1940;

          (e)  [_]  An  investment   adviser  in  accordance   with  Rule  13d-1
               (b)(1)(ii)(E);

          (f)  [_] An employee  benefit  plan,  or endowment  fund in accordance
               with Rule 13d-1 (b)(1)(ii)(F);

          (g)  [_] A parent holding company or control person in accordance with
               Rule 13d-1 (b)(1)(ii)(G);

          (h)  [_] A savings  association  as  defined  in  section  3(b) of the
               Federal Deposit Insurance Act;

          (i)  [_] A church  plan that is  excluded  from the  definition  of an
               investment  company  under  section  3(c)(14)  of the  Investment
               Company Act of 1940;

          (j)  [_] Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).

          If this statement is filed pursuant to Rule 13d-1(c),  check this box.
          [X]

Item 4.   Ownership.

          (a)  Amount beneficially owned:

               The Reporting  Person owns the amount of the Ordinary  Shares set
          forth on the cover page.

          (b)  Percent of class:

               The Reporting  Person owns the percentage of the Ordinary  Shares
          set forth on the cover page.

          (c)  Number of shares as to which such person has:

               (i) sole power to vote or to direct the vote:

                    The  Reporting  Person  has the sole power to vote or direct
               the vote of the Ordinary Shares set forth on the cover page.

               (ii) shared power to vote or to direct the vote:

                    The Reporting  Person has the shared power to vote or direct
               the vote of the Ordinary Shares set forth on the cover page.

               (iii) sole power to dispose or to direct the disposition of:

                    The Reporting Person has the sole power to dispose or direct
               the  disposition  of the  Ordinary  Shares set forth on the cover
               page.

               (iv) shared power to dispose or to direct the disposition of:

                    The  Reporting  Person  has the  shared  power to dispose or
               direct the  disposition  of the Ordinary  Shares set forth on the
               cover page.

Item 5.   Ownership of Five Percent or Less of a Class.

          Not applicable.

Item 6.   Ownership of More than Five Percent on Behalf of Another Person.

          Other than the 37,875 shares held by the Reporting  Person for its own
account,  investment  management  clients of the  subsidiaries  of the Reporting
Person listed in Item 7 have the ultimate  right to any dividends  from Ordinary
Shares and the proceeds from the sale of Ordinary Shares.

Item 7.   Identification and Classification of the Subsidiary Which Acquired the
          Security Being Reported on by the Parent Holding Company.

          The following  are  subsidiaries  of the  Reporting  Person which hold
Ordinary  Shares  included  in the  figures on the cover  pages:  DB  Industrial
Holdings AG, BOJA Beteiligungs  Aktiengesellschaft & Co. Dreizehnte Beteiligungs
KG,  Deutsche  Asset  Management   Group  Limited,   Deutsche  Asset  Management
(International) Limited, DWS Investment Management S.A. Luxemburg, Deutsche Bank
AG Sydney,  Deutsche Funds Management Inc., Deutsche Asset Management Investment
Services  Limited,  Deutsche  Gesellschaft fur  Wertpapiersparen  mbH,  Deutsche
Vermogensbildungsgesellschaft  mbH, DWS (Austria)  Investment  Gesellschaft mbH,
Finanza & Futuro S.p.A.,  Deutsche Asset Management  Investmentgesellschaft  mbH
and Deutsche Asset Management International GmbH.

Item 8.   Identification and Classification of Members of the Group.

          Not applicable.

Item 9.   Notice of Dissolution of Group.

          Not applicable.

Item 10.  Certification.

          By  signing  below I certify  that,  to the best of my  knowledge  and
belief, the securities  referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing  the control of the
issuer of the  securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.



<PAGE>



                                    SIGNATURE

                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

Dated:  February 14, 2000



                                            DEUTSCHE BANK AG



                                            By:/s/ Dr. Dieter Eisele
                                               ---------------------------------
                                               Name:   Dr. Dieter Eisele
                                               Title:  Group Head of Compliance



                                            By:/s/ Dr. Rainer Grimberg
                                               ---------------------------------
                                               Name:   Dr. Rainer Grimberg
                                               Title:  Vice President




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