PRUDENTIAL JENNISON SERIES FUND INC
24F-2NT, 1996-11-29
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            U.S. SECURITIES AND EXCHANGE COMMISSION
                    Washington, D.C.  20549

                           FORM 24F-2
                Annual Notice of Securities Sold
                     Pursuant to Rule 24f-2

    Read instructions at end of Form before preparing Form.
                     Please print or type.


     1.   Name  and  address of issuer:  Prudential Jennison Series  Fund,  Inc.
          (Formerly  Prudential Jennison Fund, Inc.), Gateway Center Three,  100
          Mulberry Street, 9th Floor, Newark, New Jersey 07102-4077.

     2.   Name of each series or class of funds for which this  notice is filed:
          The  Fund  is divided into two series, (i) Prudential Jennison  Growth
          Fund  and (ii) Prudential Jennison Growth & Income Fund.  Each  series
          offers four classes of shares designated Class A, Class B, Class C and
          Class Z.

     3.   Investment Company Act File Number:  811-7343.
          Securities Act File Number: 33-61997.

     4.   Last day of fiscal year for which this notice is filed:  September 30,
          1996.

     5.   Check  box if this notice is being filed more than 180 days after  the
          close   of  the  issuer's  fiscal  year  for   purposes  of  reporting
          securities  sold  after  the  close of  the  fiscal  year  but  before
          termination of the issuer's  24f-2 declaration:
                                                       [ ]

     6.   Date  of  termination of issuer's declaration under rule  24f-2(a)(1),
          if applicable (see instruction A.6):

     7.   Number and amount of securities of the same class or series which  had
          been  registered under the Securities Act of 1933 other than  pursuant
          to rule 24f-2 in a prior fiscal year, but which remained unsold at the
          beginning of the fiscal year: N/A

     8.   Number  and  amount of securities registered during  the  fiscal  year
          other than pursuant to rule 24f-2: N/A

     9.   Number  and aggregate sale price of securities sold during  the fiscal
          year: 77,339,884/$815,654,890

    10.   Number  and aggregate sale price of securities sold during  the fiscal
          year   in   reliance  upon  registration  pursuant  to   rule   24f-2:
          77,339,884/$815,654,890
          11.   Number and aggregate sale price of securities issued during  the
          fiscal year in connection with dividend
          reinvestment  plans,  if applicable (see instruction  B.7):          0
/$0

    12.   Calculation of registration fee:

          (i)  Aggregate sale price of securities
               sold during the fiscal year in
               reliance on rule 24f-2 (from item 10):  $815,654,890

        (ii)  Aggregate price of shares issued in
              connection with dividend reinvestment
              plans (from item 11, if applicable):     +   0

       (iii)  Aggregate price of shares redeemed or
              repurchased during the fiscal year
              (if applicable):                       -146,200,330

        (iv)  Aggregate price of shares redeemed or
              repurchased and previously applied
              as a reduction to filing fees
              pursuant to rule 24e-2
              (if applicable):                         +         0

         (v)  Net aggregate price of securities
              sold and issued during the fiscal
              year in reliance of rule 24f-2
              [line (i), plus line (ii), less
              line (iii), plus line (iv)]
              (if applicable):                       669,454,560

        (vi)  Multiplier prescribed by section
              6(b) of the Securities Act of 1933
              or other applicable law or regulation
              (see instruction C.6):                   x    1/3300

       (vii)  Fee due [line (i) or line (v)
              multiplied by line (vi)]:               202,865.02

Instructions:  Issuers  should complete lines (ii), (iii), (iv) and (v) only  if
               the  form  is being filed within 60 days after the close  of  the
               issuer's fiscal year.  See Instruction C.3.

      13.     Check   box  if  fees  are  being  remitted  to  the  Commission's
lockbox  depository as described in section 3a of the               Commission's
Rules of Informal and Other Procedures                (17 CFR 202.3a).
                                              [X]
            Date   of   mailing  or  wire  transfer  of  filing  fees   to   the
Commission's lockbox depository: November 26, 1996
                           SIGNATURES

     This report has been signed below by the following persons on behalf of the
     issuer and in the capacities and on the dates indicated.

                                               /s/S.          Jane          Rose
By (S. Jane Rose, Secretary)
     Date: November 26, 1996














GPF/PJF96.NOT





PRUDENTIAL JENNISON SERIES FUND, INC.
                              Gateway Center Three
                         100 Mulberry Street, 9th Floor
                          Newark, New Jersey 07102-4077



                                                November 26, 1996


Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, DC  20549

          Re:  Prudential Jennison Series Fund, Inc.
               (Formerly Prudential Jennison Fund, Inc.)
               File Nos. 33-61997 and 811-7343

Ladies and Gentlemen:

     On  behalf  of Prudential Jennison Series Fund, Inc. enclosed  for  filing,
under the Investment Company Act of 1940, are:

     (1)  the Form 24F-2 for the Fund; and
     (2)  an opinion of counsel to the Fund.

     These documents are being filed electronically via the EDGAR System.

     If  you  have  any  questions relating to the foregoing,  please  call  the
undersigned at (201) 367-7532.

                                   Yours truly,


                                   /s/Ellyn C. Vogin
                                   Ellyn C. Vogin
                                   Assistant Secretary



Enclosures






GPF/PJF96.LTR



Prudential Jennison Series Fund, Inc.
November 26, 1996
Page 2


                    SHEREFF, FRIEDMAN, HOFFMAN & GOODMAN, LLP
                                919 Third Avenue
                          New York, New York 10022-9998
                                        
                                        



                              November 26, 1996



Prudential Jennison Series Fund, Inc.
Gateway Center Three
100 Mulberry Street, 9th Floor
Newark, New Jersey 07102-4077

Dear Sirs:

     Prudential Jennison Series Fund, Inc., formerly Prudential Jennison Fund,
Inc. (the "Fund"), a Maryland corporation, is filing with the Securities and
Exchange Commission (the "Commission") a Rule 24f-2 Notice (the "Rule 24f-2
Notice") containing the information contained in paragraph (b)(1) of Rule 24f-2
under the Investment Company Act of 1940, as amended (the "Rule").  The effect
of the Rule 24f-2 Notice, when accompanied by the filing fee, if any, payable as
prescribed by paragraph (c) of the Rule, and by this Opinion, will be to make
definite in number the number of shares sold by the Fund during the fiscal year
ended September 30, 1996 in reliance upon the Rule (the "Rule 24f-2 Shares").

     We have, as counsel to the Fund, participated in various proceedings
relating to the Fund and to the Rule 24f-2 Shares.  We have examined copies,
either certified or otherwise proven to our satisfaction to be genuine, of the
Fund's Articles of Incorporation and By-laws, as currently in effect, the
minutes of meetings of its Board of Directors and a certificate of recent date
issued by the Department of Assessments and Taxation of the State of Maryland,
certifying the existence and good standing of the Fund.  We have also reviewed
the form of the Rule 24f-2 Notice being filed by the Fund.  We are generally
familiar with the business affairs of the Fund.

     The Fund has advised us that the Rule 24f-2 Shares were sold in the manner
contemplated by the prospectus of the Fund current at the time of each sale, and
that the Rule 24f-2 Shares were sold in number within the limits prescribed by
the Fund's Articles of Incorporation for consideration not less than the par
value thereof and the net asset value thereof as required by the Investment
Company Act of 1940, as amended.

     Based upon the foregoing, it is our opinion that:

     1.   The Fund has been duly organized and is legally existing under the
          laws of the State of Maryland.

     2.   The Fund is authorized by its Articles of Incorporation to issue two
          billion five hundred million (2,500,000,000) shares of common stock.
          Under Maryland law (i) the Board of Directors of the Fund may increase
          or decrease the number of shares that the Fund has authority to issue,
          and (ii) shares which were issued and which have subsequently been
          redeemed by the Fund are, by virtue of such redemption, restored to
          the status of authorized and unissued shares.

     3.   The Rule 24f-2 Shares were legally issued and are fully paid and non-
          assessable.

     We hereby consent to the filing of this Opinion with the Securities and
Exchange Commission together with the Rule 24f-2 Notice of the Fund, and to the
filing of this Opinion under the securities laws of any state.

     We are members of the Bar of the State of New York and do not hold
ourselves out as being conversant with the laws of any jurisdiction other than
those of the United States of America and the State of New York.  We note that
we are not licensed to practice law in the State of Maryland, and to the extent
that any opinion herein involves the law of Maryland, such opinion should be
understood to be based solely upon our review of the documents referred to
above, the published statutes of the State of Maryland and, where applicable,
published cases, rules or regulations of regulatory bodies of that State.




                         Very truly yours,

                         /s/ Shereff, Friedman, Hoffman & Goodman, LLP

                         Shereff, Friedman, Hoffman & Goodman, LLP


SFH&G:MKN:JLS:GNB:jlk




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