PRUDENTIAL JENNISON SERIES FUND INC
24F-2NT, 1997-12-03
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             U.S. SECURITIES AND EXCHANGE COMMISSION
                     Washington, D.C.  20549

                            FORM 24F-2
                 Annual Notice of Securities Sold
                      Pursuant to Rule 24f-2

     Read instructions at end of Form before preparing Form.
                      Please print or type.



     1.   Name  and address of issuer: Prudential Jennison Series   Fund,  Inc.,
          100 Mulberry Street, Gateway Center Three,   Newark, New Jersey 07102-
          4077.

     2.     Name of each series or class of securities for which this   
       Form is filed (If the Form is being filed for all series   and 
       classes of securities of the issuer, check the box but do not list 
       series or classes):
                                                       [x]
     
     3.   Investment Company Act File Number:  811-7347.
          Securities Act File Number: 33-61997.
     
     4(a).Last  day of fiscal year for which this Form is filed:  September  30,
          1997.

      (b).[ ] Check box if this Form is being filed late (i.e. more
          than 90 calendar days after the end of the issuer's fiscal year). (See
          Instruction A.2)

     Note:  If  the  Form  is being filed late, interest must  be  paid  on  the
     registration fee due.

     4(c).[  ] Check box if this is the last time the issuer will be      filing
     this Form.
     
     5.   Calculation of registration fee:

         (i) Aggregate sale price of securities
             sold during the fiscal year pursuant
             to section 24(f):                      $984,231,351

        (ii) Aggregate price of securities redeemed
             or repurchased during the fiscal year
             (if applicable):                       $688,670,806

       (iii) Aggregate price of securities redeemed
             or repurchased during any prior fiscal
             year ending no earlier than October 11,
             1995 that were not previously used to
             reduce registration fees payable to the
             Commission.                           $     0

        (iv)Total available redemption credits
             [add items 5(ii) and 5(iii)].         $688,670,806

         (v)Net sales - If item 5(i) is greater
             than Item 5(iv) [subtract item 5(iv)
             from item 5(i).                        $295,560,545
        (vi)      Redemption credits available for use
             in future years.
             -if item 5(i) is less than item 5(iv)
             [subtract item 5(i) from item (5(iv)]  $     0

       (vii)     Multiplier for determining registration
             fee (See instruction C.9):             x   .000295

      (viii)    Registration fee due [multiply item 5(v)
             by item 5(vii)] enter "0" if no fee is
             due.                                   =$87,190.36

          6.   Prepaid Shares

           If  the response to item 5(i) was determined by deducting          an
amount of securities that were registered under the              Securities  Act
of  1933 pursuant to rule 24e-2 as in              effect October 11, 1997, then
report the amount of
          securities (number of shares or other units) deducted
          here:          .  If there is a number of shares or other
          units that were registered pursuant to rule 24e-2
          remaining unsold at the end of the fiscal year for which
          this form is filed that are available for use by the
          issuer in future fiscal years, then state that number
          here:         .

     7.   Interest due - if this Form is being filed
             more than 90 days after the end of the of
             the issuer's fiscal year (See Instruction D):+$
          8.   Total amount of the registration fee due
               plus any interest due [line 5(viii)plus
                  line    7]:                                        =$87,190.36
     
         9.   Date the registration fee and any interest payment was
         sent to the Commission's lockbox depository:

                                       November 21, 1997
         Method of Delivery:

                   [x] Wire Transfer
                   [ ] Mail or other means


                                   SIGNATURES

This report has been signed below by the following persons on          behalf of
the issuer and in the capacities and on the dates            indicated.

By (Signature and Title)  /s/ Marguerite E.H. Morrison
                           Marguerite E.H. Morrison

                           Assistant Secretary

Date: December 3, 1997







PRUDENTIAL JENNISON SERIES FUND, INC.
Gateway Center Three
100 Mulberry Street, 9th Floor
Newark, NJ 07102-4077





                                                 December 3, 1997



Securities and Exchange Commission
450 Fifth Street, NW
Washington, DC  20549

     Re:  Rule 24f-2 Notice for Prudential Jennison Series Fund,
               Inc.  File Nos. 33-61997 and 811-7347

          On  behalf  of  Prudential Jennison Series Fund,  Inc.,  enclosed  for
     filing under the Investment Company Act of 1940 is one copy of the Rule 
     24f- 2 Notice.  This document has been filed using the EDGAR system.  
     Should you have any questions, please contact me at (973) 367-7525.

                                   Very truly yours,


                                   /s/ Marguerite E.H. Morrison
                                   Marguerite E. H. Morrison
                                   Assistant Secretary

MM/ln
Enclosures






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