PRUDENTIAL JENNISON SERIES FUND INC
DEFA14A, 1998-05-19
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May 13, 1998

Dear Shareholder:

  Pending shareholder approval of the proxy statement that you will receive in
the next week, the Prudential Multi-Sector Fund, Inc. will close on June 26, 
1998. All assets of the Fund will be acquired by the Prudential Jennison Growth
Fund and you will receive Prudential Jennison Growth Fund shares equivalent in 
value to your Fund shares. We encourage you to read your prospectus and 
forthcoming proxy statement for a complete discussion of this proposed 
reorganization.

  Beginning this month, we will automatically allocate your monthly investment
to the Jennison Growth Fund. If you would rather allocate your investment to 
another Prudential Fund, or want to discuss your options, please call us at 
(800) 225-1852 before Friday, June 19, 1998.

Reasons for the reorganization
The Board of the Multi-Sector Fund has determined that this reorganization is 
in the best interest of the Fund's shareholders for the following reasons:

The Jennison Growth Fund has outperformed the Multi-Sector Fund.  While past 
performance does not guarantee future results, the performance of the Jennison
Growth Fund has been stronger than that of the Multi-Sector Fund (the table on
page 4 of your proxy statement will contain certain performance information 
for your reference).

Lower expense ratios for Jennison Growth Fund shares.  Shares of the Jennison 
Growth Fund had lower expense ratios than those of the Multi-Sector Fund in 
the fiscal year ending April 30, 1997. Although we cannot give blanket 
assurances, if shareholders of the Multi-Sector Fund approve the merger, it is
likely that as Jennison Growth Fund shareholders they will be subject to lower
expense ratios.

The Funds have the same principal objective and share similar investment 
policies.  The Funds have identical investment objectives: long-term growth of
capital. The Multi-Sector Fund has a secondary objective of current income.  
As of March 13, 1998, more than 90% of the Multi-Sector Fund's investments 
conformed to the investment policies of the Jennison Growth Fund.

The Funds have many of the same service providers.  Prudential Investments Fund
Management serves as the manager of each Fund and Prudential Securities 
Incorporated serves as their distributor. Prudential Mutual Fund Services LLC
is their transfer agent and dividend disbursing agent, and State Street Bank 
and Trust Company is custodian for each of the Funds.  The same individuals 
serve on the Board of Directors of each Fund.  David Poiesz, a Vice President 
of The Prudential Investment Corporation and a Director and Senior Vice 
President of Jennison Associates LLC, is the Portfolio Manager of both Funds.

We believe these are compelling reasons for the reorganization. If you have 
any questions about this merger, or about your monthly investment, please call
us at (800) 225-1852.

Sincerely,

Brian M. Storms
President, Prudential Mutual Funds

PIMV 0598-3423


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