PHARMACYCLICS INC
DEFR14A, 1997-10-31
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
 
                            SCHEDULE 14A INFORMATION
                                 (RULE 14a-101)
                    INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
                PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE
                        SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO.   )
 
     Filed by the registrant [X]
 
     Filed by a Party other than the registrant [ ]
 
     Check the appropriate box:
 
     [ ]  Preliminary Proxy Statement   [ ]  Confidential, for Use of the 
                                             Commission Only (as permitted by 
                                             Rule 14a-6(e)(2))
     [X]  Definitive Proxy Statement
     [ ]  Definitive Additional Materials
     [ ]  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                              Pharmacyclics, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)
 
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than Registrant)
 
Payment of Filing Fee (Check the appropriate box):
 
     [X]  No fee required.
 
     [ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) 
and 0-11.
 
     (1)  Title of each class of securities to which transaction applies:
 
          --------------------------------------------------------------------- 
 
     (2)  Aggregate number of securities to which transaction applies:
 
          --------------------------------------------------------------------- 
 
     (3)  Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the filing
fee is calculated and state how it was determined):
 
          --------------------------------------------------------------------- 
 
     (4)  Proposed maximum aggregate value of transaction:
 
          --------------------------------------------------------------------- 

     (5)  Total fee paid:
 
          --------------------------------------------------------------------- 
 
     [ ]  Fee paid previously with preliminary materials.
 
     [ ]  Check box if any part of the fee is offset as provided by Exchange Act
Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid
previously. Identify the previous filing by registration statement number, or
the Form or Schedule and the date of its filing.
 
     (1)  Amount Previously Paid:

          --------------------------------------------------------------------- 
     (2)  Form, Schedule or Registration Statement No.:
 
          --------------------------------------------------------------------- 
     (3)  Filing Party:
 
          --------------------------------------------------------------------- 
     (4)  Date Filed:

          --------------------------------------------------------------------- 
<PAGE>   2
 
                              PHARMACYCLICS, INC.
                             995 EAST ARQUES AVENUE
                          SUNNYVALE, CALIFORNIA 94086
 
                               NOVEMBER 14, 1997
 
DEAR STOCKHOLDER:
 
     You are cordially invited to attend the Annual Meeting of Stockholders
("Annual Meeting") of Pharmacyclics, Inc. (the "Company") which will be held at
11:30 A.M. on December 17, 1997, at Embassy Suites, 2885 Lakeside Drive, Santa
Clara, California 95054.
 
     At the Annual Meeting, you will be asked to consider and vote upon the
following proposals:
 
          (i) the election of six (6) directors to serve until the 1998 annual
     meeting and until their successors are elected and qualified;
 
          (ii) the amendment of the Company's 1995 Stock Option Plan (the
     "Option Plan") in order to increase the total number of shares of common
     stock authorized for issuance over the term of the Option Plan by an
     additional 500,000 shares and to make such other changes as described
     herein;
 
          (iii) the amendment of the Company's Employee Stock Purchase Plan (the
     "Purchase Plan") in order to increase the total number of shares of common
     stock authorized for issuance over the term of the Purchase Plan by an
     additional 50,000 shares; and
 
          (iv) the ratification of the appointment of Price Waterhouse LLP as
     the Company's independent accountants for the fiscal year ending June 30,
     1998.
 
     The enclosed Proxy Statement more fully describes the details of the
business to be conducted at the Annual Meeting.
 
     After careful consideration, the Company's Board of Directors has
unanimously approved the proposals and recommends that you vote IN FAVOR OF each
such proposal.
 
     After reading the Proxy Statement, please mark, date, sign and return by no
later than December 5, 1997, the enclosed proxy card in the accompanying reply
envelope. If you decide to attend the Annual Meeting, please notify the
Secretary of the Company that you wish to vote in person and your proxy will not
be voted. YOUR SHARES CANNOT BE VOTED UNLESS YOU MARK, DATE, SIGN AND RETURN THE
ENCLOSED PROXY, OR ATTEND THE ANNUAL MEETING IN PERSON.
 
     Copies of the Pharmacyclics, Inc. 1997 Annual Report and Annual Report on
Form 10-K for the fiscal year ended June 30, 1997 are also enclosed.
 
     We look forward to seeing you at the Annual Meeting.
 
                                          Sincerely,
 
                                          Richard A. Miller, M.D.
                                          President and Chief Executive Officer
 
                                   IMPORTANT
 
     PLEASE MARK, DATE, SIGN AND RETURN THE ENCLOSED PROXY PROMPTLY IN THE
ACCOMPANYING POSTAGE-PAID RETURN ENVELOPE SO THAT YOUR SHARES MAY BE VOTED IF
YOU ARE UNABLE TO ATTEND THE ANNUAL MEETING.
<PAGE>   3
 
                              PHARMACYCLICS, INC.
                            ------------------------
 
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
 
                               DECEMBER 17, 1997
 
TO THE STOCKHOLDERS OF PHARMACYCLICS, INC.:
 
     NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders ("Annual
Meeting") of Pharmacyclics, Inc., a Delaware corporation (the "Company"), will
be held at 11:30 A.M. local time on Wednesday, December 17, 1997, at Embassy
Suites, 2885 Lakeside Drive, Santa Clara, California 95054, for the following
purposes:
 
          1. To elect a Board of six (6) directors to serve for the ensuing year
     and until their respective successors are elected and qualified.
 
          2. To approve an amendment to the Company's 1995 Stock Option Plan
     (the "Option Plan") including an increase in the total number of shares of
     common stock authorized for issuance over the term of the Option Plan by an
     additional 500,000 shares.
 
          3. To approve an amendment to the Company's Employee Stock Purchase
     Plan (the "Purchase Plan") in order to increase the total number of shares
     of common stock authorized for issuance over the term of the Purchase Plan
     by an additional 50,000 shares.
 
          4. To ratify the appointment of Price Waterhouse LLP as the Company's
     independent accountants for the fiscal year ending June 30, 1998.
 
          5. To transact such other business as may properly come before the
     Annual Meeting and any adjournment or adjournments thereof.
 
     The foregoing items of business are more fully described in the Proxy
Statement accompanying this Notice.

   
     Stockholders of record at the close of business on October 30, 1997 are
entitled to receive notice of and to vote at the Annual Meeting and any
adjournment thereof. A list of the stockholders entitled to vote at the Annual
Meeting will be available for inspection at the Company's offices for a period
of ten (10) days immediately prior to the Annual Meeting.
    
 
     All stockholders are cordially invited to attend the Annual Meeting.
However, to assure your representation at the meeting, please carefully read the
accompanying Proxy Statement which describes the matters to be voted upon at the
Annual Meeting and mark, date, sign and return the enclosed proxy card in the
accompanying reply envelope. Should you receive more than one proxy because your
shares are registered in different names and addresses, each proxy should be
returned to ensure that all your shares will be voted. If you decide to attend
the Annual Meeting, please notify the Secretary of the Company that you wish to
vote in person and your proxy will not be voted and only your vote at the Annual
Meeting will be counted. The prompt return of your proxy card will assist us in
preparing for the Annual Meeting.
 
                                          Sincerely,
 
                                          J. Stephan Dolezalek,
                                          Secretary
Sunnyvale, California
November 14, 1997
 
YOUR VOTE IS VERY IMPORTANT. PLEASE READ THE ATTACHED PROXY STATEMENT CAREFULLY.
IF YOU DO NOT EXPECT TO ATTEND THE ANNUAL MEETING IN PERSON, PLEASE COMPLETE,
SIGN, DATE AND RETURN THE ENCLOSED PROXY CARD IN THE ACCOMPANYING ENVELOPE AS
PROMPTLY AS POSSIBLE.
<PAGE>   4
 
                              PHARMACYCLICS, INC.
                             995 EAST ARQUES AVENUE
                          SUNNYVALE, CALIFORNIA 94086
 
                            ------------------------
 
                                PROXY STATEMENT
 
                            ------------------------
 
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                        TO BE HELD ON DECEMBER 17, 1997
 
                      GENERAL INFORMATION FOR STOCKHOLDERS
 
     THE ENCLOSED PROXY ("PROXY") IS SOLICITED ON BEHALF OF THE BOARD OF
DIRECTORS (THE "BOARD") OF PHARMACYCLICS, INC., A DELAWARE CORPORATION (THE
"COMPANY"), FOR USE AT THE 1997 ANNUAL MEETING OF STOCKHOLDERS (THE "ANNUAL
MEETING") TO BE HELD AT 11:30 A.M. ON DECEMBER 17, 1997, AT EMBASSY SUITES, 2885
LAKESIDE DRIVE, SANTA CLARA, CALIFORNIA 95054 AND AT ANY ADJOURNMENT THEREOF.
 
     This Proxy Statement and the accompanying form of Proxy was first mailed to
the stockholders entitled to vote at the Annual Meeting on or about November 14,
1997.
 
RECORD DATE AND VOTING
   
     Stockholders of record at the close of business on October 30, 1997 are
entitled to notice of and to vote at the Annual Meeting. As of the close of
business on such date, there were 10,184,643 shares of the Company's common
stock (the "Common Stock") outstanding and entitled to vote, held by
approximately 525 stockholders of record. No shares of the Company's preferred
stock are outstanding. Each stockholder is entitled to one vote for each share
of Common Stock held by such stockholder as of the record date. If a choice as
to the matters coming before the Annual Meeting has been specified by a
stockholder on the Proxy, the shares will be voted accordingly. If no choice is
specified, the shares will be voted IN FAVOR OF the approval of the proposals
described in the Notice of Annual Meeting of Stockholders and in this Proxy
Statement. Abstentions and broker non-votes (i.e., the submission of a Proxy by
a broker or nominee specifically indicating the lack of discretionary authority
to vote on the matter) are counted for purposes of determining the presence or
absence of a quorum for the transaction of business. Abstentions will be counted
towards the tabulation of votes cast on proposals presented to the stockholders
and will have the same effect as negative votes, whereas broker non-votes will
not be counted for purposes of determining whether a proposal has been approved
or not.
    
     Any stockholder or stockholder's representative who, because of a
disability, may need special assistance or accommodation to allow him or her to
participate at the Annual Meeting may request reasonable assistance or
accommodation from the Company by contacting Cheryl B. Jaszewski, Vice
President, Finance and Administration, in writing at 995 East Arques Avenue,
Sunnyvale, California 94086 or by telephone at (408) 774-0330. To provide the
Company sufficient time to arrange for reasonable assistance, please submit such
requests by December 7, 1997.
 
REVOCABILITY OF PROXIES
 
     Any stockholder giving a Proxy pursuant to this solicitation may revoke it
at any time prior to the meeting by filing with the Secretary of the Company at
its principal executive offices at 995 East Arques Avenue, Sunnyvale, California
94086, a written notice of such revocation or a duly executed Proxy bearing a
later date, or by attending the Annual Meeting and voting in person.
<PAGE>   5
 
SOLICITATION
 
     The Company will bear the entire cost of solicitation, including the
preparation, assembly, printing and mailing of the Notice of Annual Meeting,
this Proxy Statement, the Proxy and any additional solicitation materials
furnished to stockholders. Copies of solicitation materials will be furnished to
brokerage houses, fiduciaries and custodians holding shares in their names that
are beneficially owned by others so that they may forward this solicitation
material to such beneficial owners. The Company has engaged Corporate Investor
Communications, Inc. ("CIC") to provide routine advice and services for Proxy
solicitation. CIC will receive approximately $4,000 from the Company for such
advice and services, plus reimbursement of costs incurred in forwarding the
solicitation materials to the beneficial owners of Common Stock. To assure that
a quorum will be present in person or by proxy at the Annual Meeting, it may be
necessary for CIC, certain officers, directors, employees or other agents of the
Company to solicit proxies by telephone, facsimile or other means or in person.
Except with respect to CIC, the Company will not compensate such individuals for
any such services. Except as described above, the Company does not presently
intend to solicit proxies other than by mail.
 
                                   IMPORTANT
 
     PLEASE MARK, DATE, SIGN AND RETURN THE ENCLOSED PROXY IN THE ACCOMPANYING
POSTAGE-PREPAID ENVELOPE NO LATER THAN DECEMBER 5, 1997, SO THAT YOUR SHARES MAY
BE VOTED IF YOU ARE UNABLE TO ATTEND THE ANNUAL MEETING.
 
     THE COMPANY'S ANNUAL REPORT TO STOCKHOLDERS FOR THE FISCAL YEAR ENDED JUNE
30, 1997 (THE "ANNUAL REPORT") AND THE ANNUAL REPORT ON FORM 10-K FOR THE FISCAL
YEAR ENDED JUNE 30, 1997, AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
(THE "FORM 10-K"), HAVE BEEN MAILED CONCURRENTLY WITH THE MAILING OF THE NOTICE
OF ANNUAL MEETING AND PROXY STATEMENT TO ALL STOCKHOLDERS ENTITLED TO NOTICE OF
AND TO VOTE AT THE ANNUAL MEETING. NEITHER THE ANNUAL REPORT NOR THE FORM 10-K
IS CONSIDERED PROXY-SOLICITING MATERIAL AND NEITHER IS INCORPORATED INTO THIS
PROXY STATEMENT.
 
                                        2
<PAGE>   6
 
                 MATTERS TO BE CONSIDERED AT THE ANNUAL MEETING
 
                     PROPOSAL ONE -- ELECTION OF DIRECTORS
 
     At the Annual Meeting, a Board of six directors will be elected to serve
until the Company's next Annual Meeting and until their successors shall have
been duly elected and qualified or until their earlier death, resignation or
removal. The Board has selected six nominees, all of whom are current directors
of the Company. Each person nominated for election has agreed to serve if
elected, and management has no reason to believe that any nominee will be
unavailable to serve. Unless otherwise instructed, the Proxy holders will vote
the Proxies received by them IN FAVOR OF the nominees named below. The six
candidates receiving the highest number of affirmative votes of all the shares
entitled to vote at the Annual Meeting will be elected. If any nominee is unable
to or declines to serve as a director, the Proxies may be voted for a substitute
nominee designated by the current Board. As of the date of this Proxy Statement,
the Board is not aware of any nominee who is unable or will decline to serve as
a director.
 
     THE BOARD RECOMMENDS THAT STOCKHOLDERS VOTE IN FAVOR OF THE ELECTION OF
EACH OF THE FOLLOWING NOMINEES TO SERVE AS DIRECTORS OF THE COMPANY UNTIL THE
NEXT ANNUAL MEETING AND UNTIL THEIR SUCCESSORS HAVE BEEN DULY ELECTED AND
QUALIFIED OR UNTIL THEIR EARLIER DEATH, RESIGNATION OR REMOVAL.
 
INFORMATION WITH RESPECT TO DIRECTOR NOMINEES
 
     Set forth below is information regarding the nominees.
 
<TABLE>
<CAPTION>
          NAME                 AGE          POSITION(S) WITH THE COMPANY      DIRECTOR SINCE
- -------------------------      ---         -------------------------------    ---------------
<S>                            <C>         <C>                                <C>
Thomas D. Kiley                54          Director                                 1991
Joseph S. Lacob                41          Director                                 1991
Patrick F. Latterell           39          Director                                 1991
Richard A. Miller, M.D.        46          Director, President and Chief            1991
                                           Executive Officer
Joseph C. Scodari              44          Director                                 1994
Craig C. Taylor                47          Director                                 1991
</TABLE>
 
BUSINESS EXPERIENCE OF DIRECTOR NOMINEES
 
     MR. KILEY was elected as a Director of the Company in June 1991. He has
been self-employed since 1988 as an attorney, consultant and investor. From 1980
to 1988, he was an officer of Genentech, Inc., serving variously as Vice
President and General Counsel, Vice President for Legal Affairs and Vice
President for Corporate Development. Mr. Kiley is also a director of
Cardiogenesis Corporation, a medical device company, Connective Therapeutics,
Inc. and Geron Corporation, pharmaceutical companies, and certain private
biotechnology and other companies.
 
     MR. LACOB was elected as a Director of the Company in June 1991. He is a
General Partner of Kleiner Perkins Caufield & Byers, a venture capital
investment firm which he joined in 1987. Mr. Lacob is currently Chairman of the
Board of CellPro, Inc. and Microcide Pharmaceuticals, Inc. and a director of
Heartport, Inc., as well as several private life science companies.
 
     MR. LATTERELL was elected as a Director of the Company in June 1991. He is
a General Partner of Venrock Associates and Venrock Associates II, L.P., venture
capital investment groups, which he joined in April 1989. Mr. Latterell is
currently a director of Biocircuits Corporation, Vical, Inc. and several private
biomedical companies.
 
     DR. MILLER has served as President, Chief Executive Officer and a Director
since the Company was founded in April 1991. In 1984, Dr. Miller co-founded IDEC
Pharmaceuticals Corporation where he served as Vice President and a director
until February 1992. In 1989, Dr. Miller co-founded CellPro, Inc. ("CellPro"), a
public biotechnology company, and served as a director of CellPro from 1989 to
1991 and Chairman of
 
                                        3
<PAGE>   7
 
CellPro's Scientific Advisory Board until 1993. Dr. Miller also is a Clinical
Professor of Medicine (Oncology) at Stanford University Medical Center.
 
     MR. SCODARI was elected as a Director of the Company in December 1994. He
is Corporate Executive Vice President and President, Pharmaceutical Division for
Centocor, Inc. Prior to joining Centocor, he was Senior Vice President and
General Manager, North American Ethicals, for Rhone-Poulenc Rorer
Pharmaceuticals, Inc., where he held various positions since 1989. From 1987 to
1989, Mr. Scodari was Executive Vice President of Sterling Drug's U.S.
Diagnostic Imaging Division ("Sterling") where he held responsibilities for all
marketing and sales and business development activities for Sterling's imaging
agent business.
 
     MR. TAYLOR was elected as a Director of the Company in June 1991. He is a
General Partner of AMC Partners '89, L.P., the general partner of Asset
Management Associates 1989, L.P., a private venture capital partnership. Mr.
Taylor has been with Asset Management Company, a venture management group, since
1977. Mr. Taylor is a director of Metra BioSystems, Inc., Lynx Therapeutics,
Inc. and several private companies.
 
     There are no family relationships among executive officers or directors of
the Company.
 
BOARD MEETINGS AND COMMITTEES
 
     During the fiscal year ended June 30, 1997, the Board held seven meetings.
As of June 30, 1997, the Company had two standing Committees: an Audit Committee
and a Compensation Committee. The Company does not have a standing Nominating
Committee.
 
     The Audit Committee is primarily responsible for approving the services
performed by the Company's independent accountants and reviewing reports of the
Company's internal and external auditors regarding the Company's accounting
practices and systems of internal accounting controls. During the fiscal year
ended June 30, 1997, the Audit Committee consisted of two directors, Messrs.
Latterell and Taylor. The Audit Committee held one meeting during the fiscal
year ended June 30, 1997.
 
     The Compensation Committee reviews and approves the Company's general
compensation policies, sets compensation levels for the Company's executive
officers and administers the Company's 1995 Stock Option Plan, successor to the
Company's 1992 Stock Option Plan, and the Company's Employee Stock Purchase
Plan. During the fiscal year ended June 30, 1997, the Compensation Committee
consisted of three directors, Messrs. Lacob, Latterell and Taylor. The
Compensation Committee met six times during the fiscal year ended June 30, 1997.
 
     During the last fiscal year no director attended fewer than 75% of the
aggregate number of meetings of the Board and meetings of Committees of the
Board on which such director serves, which were held during the period that such
individual was a member of the Board.
 
DIRECTOR COMPENSATION
 
     The non-employee Board members do not receive any cash compensation for
their service on the Board or any Committee of the Board. However, Mr. Scodari
is reimbursed for travel expenses incurred in attending Board or Committee
meetings.
 
     Under the Company's Non-Employee Directors Stock Option Plan (the
"Directors Plan"), each new non-employee Board member will receive an automatic
option grant for 10,000 shares of Common Stock under the Directors Plan on the
date of his or her initial election or appointment to the Board. Furthermore, on
the date of each Annual Stockholders Meeting, each individual re-elected as a
non-employee Board member will receive an automatic option grant for an
additional 5,000 shares of Common Stock, provided such individual has served as
a Board member for at least six months. The exercise price per share of Common
Stock subject to each automatic option grant will be equal to the fair market
value per share on the automatic grant date. Each automatic grant will have a
term of ten years, subject to earlier termination following the optionee's
cessation of Board service. Each automatic grant will be immediately
exercisable; however, any
 
                                        4
<PAGE>   8
 
shares purchased upon exercise of the option will be subject to repurchase
should the optionee's service as a non-employee Board member cease prior to
vesting in the shares. Each 10,000-share grant will vest in five equal and
successive annual installments over the optionee's period of Board service. Each
5,000-share grant will vest in 12 equal and successive monthly installments over
the optionee's period of Board service. However, each outstanding option will
immediately vest upon (i) certain changes in the ownership or control of the
Company or (ii) the death or disability of the optionee while serving as a Board
member.
 
     Messrs. Kiley, Lacob, Latterell, Scodari and Taylor each received an option
for 5,000 shares on December 6, 1996. Each such option has an exercise price of
$16.00 per share, the fair market value per share of Common Stock on the grant
date.
 
                         PROPOSAL TWO -- APPROVAL OF AN
                      AMENDMENT TO 1995 STOCK OPTION PLAN
 
INTRODUCTION
 
     The Company's stockholders are being asked to approve an amendment to the
1995 Stock Option Plan (the "Option Plan") which will effect the following
changes: (i) increase the maximum number of shares available for issuance under
the Option Plan by an additional 500,000 shares, (ii) increase the maximum
number of shares for which options and separately exercisable stock appreciation
rights may be granted to any one individual to 750,000 shares, (iii) eliminate
the restriction that the individuals who serve as Plan Administrator may not
receive any discretionary option grants from the Company, (iv) allow unvested
shares issued under the Option Plan and subsequently repurchased by the Company
at the option exercise price paid per share to be reissued under the Option
Plan, (v) remove certain restrictions on the eligibility of non-employee Board
members to serve as Plan Administrator and (vi) effect a series of additional
changes to the provisions of the Option Plan (including the stockholder approval
requirements) in order to take advantage of the recent amendments to Rule 16b-3
of the Securities and Exchange Commission which exempts certain officer and
director transactions under the Option Plan from the short-swing liability
provisions of the Federal securities laws.
 
     The amendment was adopted by the Board on September 11, 1997, subject to
stockholder approval at the Annual Meeting. The Board believes that the increase
in the share reserve is necessary in order to ensure that the Company will have
a sufficient reserve of Common Stock under the Option Plan to continue to
attract and retain the services of key individuals essential to the Company's
long-term growth and success. The increase in the maximum number of shares for
which any one individual may be granted options and separately exercisable stock
appreciation rights is necessary to ensure that any compensation deemed paid to
the Company's executive officers in connection with the exercise of options
continues to remain deductible by the Company and will be excluded from the $1
million limit on the deductibility of compensation paid to certain officers of
the Company. The Board believes the other amendments are needed in order to
provide the Company with more opportunities to make equity incentives available
to the non-employee Board members as an inducement for their continued service
and to facilitate plan administration in light of the new changes to Rule 16b-3.
 
     The terms and provisions of the Option Plan, as amended through September
11, 1997, are summarized more fully below. This summary, however, does not
purport to be a complete description of all the provisions of the Option Plan. A
copy of the Option Plan will be furnished by the Company to any stockholder upon
written request to the Secretary of the Company at the Company's principal
offices in Sunnyvale, California.
 
PLAN STRUCTURE
 
     Under the Option Plan, eligible persons may, at the discretion of the Plan
Administrator (as defined below), be granted options to purchase shares of
Common Stock at an exercise price not less than 85% of the fair market value of
such shares on the grant date. The Option Plan is currently administered by the
Compensation Committee of the Board. This committee (the "Plan Administrator")
has complete discretion (subject to the provisions of the Option Plan) to
authorize option grants under the Option Plan.
 
                                        5
<PAGE>   9
 
SHARE RESERVE
 
     The maximum number of shares of Common Stock issuable over the term of the
Option Plan may not exceed 2,261,565 shares, including the 500,000-share
increase for which stockholder approval is sought under this Proposal Two. On
the first trading date of each calendar year beginning with the 1996 calendar
year, the share reserve will automatically increase by an amount equal to one
percent (1%) of the number of shares of Common Stock outstanding on the last day
of the preceding calendar year; provided that such annual increase may not
exceed 500,000 shares. The increase on January 2, 1997 was in an amount equal to
91,503 shares.
 
     The maximum number of shares as to which any one individual participating
in the Option Plan may be granted stock options and separately exercisable stock
appreciation rights may not exceed 750,000 shares in the aggregate over the term
of the Option Plan (assuming approval of this Proposal Two).
 
     Should any option terminate prior to exercise in full, the shares subject
to the unexercised portion of that option will be available for subsequent
option grants. In addition, any unvested shares issued under the Option Plan and
subsequently repurchased by the Company at the original exercise price paid per
share pursuant to the Company's repurchase rights under the Option Plan will be
added back to the number of shares of Common Stock reserved for issuance under
the Option Plan and will accordingly be available for reissuance through one or
more subsequent option grants made under the Option Plan.
 
     In the event any change is made to the Common Stock issuable under the
Option Plan (by reason of any stock dividend, stock split, combination of
shares, recapitalization, or other change affecting the outstanding Common Stock
as a class without receipt of consideration), appropriate adjustments will be
made to the number and/or class of securities available for issuance (in the
aggregate and to each optionee) under the Option Plan.
 
     As of September 30, 1997, 1,278,600 shares were subject to outstanding
option grants under the Option Plan, 982,965 shares remained available for
future grants (assuming approval of this Proposal Two), and 567,241 shares have
been issued under the Option Plan.
 
ELIGIBILITY
 
     Officers, other employees of the Company and its parent or subsidiaries,
non-employee members of the Board and the board of directors of its parent or
subsidiaries and independent consultants of the Company and its parent or
subsidiary corporations are eligible to participate in the Option Plan.
Non-employee Board members are also eligible to receive automatic option grants
under the Non-Employee Directors Stock Option Plan (the "Directors Plan").
 
     As of September 30, 1997 approximately four executive officers, 46 other
employees and five non-employee Board members were eligible to participate in
the Option Plan (assuming approval of this Proposal Two), and five non-employee
Board members were eligible to participate in the Directors Plan.
 
VALUATION
 
     For purposes of establishing the option exercise price and for all other
valuation purposes under the Option Plan, the fair market value per share of
Common Stock on any relevant date will be the closing selling price per share as
reported on the Nasdaq National Market. As of September 30, 1997, the fair
market value per share of the Common Stock was $24.75 per share, as reported on
the Nasdaq National Market.
 
TERMS OF OPTION GRANT PROGRAM
 
     Options may be granted at an exercise price per share not less than eighty
five percent (85%) of the fair market value per share of Common Stock on the
option grant date. No granted option will have a term in excess of ten years.
 
     Upon cessation of service, the optionee will have a limited period of time
in which to exercise any outstanding option to the extent such option is
exercisable for vested shares. The Plan Administrator will have complete
discretion to extend the period following the optionee's cessation of service
during which his or her
 
                                        6
<PAGE>   10
 
outstanding options may be exercised and/or to accelerate the exercisability or
vesting of such options in whole or in part. Such discretion may be exercised at
any time while the options remain outstanding, whether before or after the
optionee's actual cessation of service.
 
     The Plan Administrator is authorized to issue two types of stock
appreciation rights in connection with option grants made under Option Plan:
 
     Tandem stock appreciation rights provide the holders with the right to
     surrender their options for an appreciation distribution from the
     Company equal in amount to the excess of (a) the fair market value of
     the vested shares of Common Stock subject to the surrendered option
     over (b) the aggregate exercise price payable for such shares. Such
     appreciation distribution may, at the discretion of the Plan
     Administrator, be made in cash or in shares of Common Stock.
 
     Limited stock appreciation rights may be granted to officers of the
     Company as part of their option grants. Any option with such a limited
     stock appreciation right may be surrendered to the Company upon the
     successful completion of a hostile take-over of the Company. In return
     for the surrendered option, the officer will be entitled to a cash
     distribution from the Company in an amount per surrendered option
     share equal to the excess of (a) the take-over price per share over
     (b) the exercise price payable for such share.
 
     The Plan Administrator will have the authority to effect the cancellation
of outstanding options under the Option Plan which have exercise prices in
excess of the then current market price of Common Stock and to issue replacement
options with an exercise price based on the market price of Common Stock at the
time of the new grant.
 
GENERAL PROVISIONS
 
     Acceleration. In the event that the Company is acquired by merger or asset
sale, each outstanding option under the Option Plan which is not to be assumed
by the successor corporation or replaced with a comparable option to purchase
shares of the capital stock of the successor corporation will automatically
accelerate in full. Any options assumed or replaced in connection with such
acquisition will be subject to immediate acceleration, and any unvested shares
which do not vest at the time of such acquisition will be subject to full and
immediate vesting, in the event the individual's service is subsequently
terminated within 18 months following the acquisition. In connection with a
hostile change in control of the Company (whether by successful tender offer for
more than 50% of the outstanding voting stock or by proxy contest for the
election of Board members), the Plan Administrator will have the discretionary
authority to provide for automatic acceleration of outstanding options under the
Option Plan either at the time of such change in control or upon the subsequent
termination of the individual's service.
 
     The acceleration of vesting in the event of a change in the ownership or
control of the Company may be seen as an anti-takeover provision and may have
the effect of discouraging a merger proposal, a takeover attempt or other
efforts to gain control of the Company.
 
     Financial Assistance. The Plan Administrator may permit one or more
participants to pay the exercise price of outstanding options or the purchase
price of shares under the Option Plan by delivering a promissory note payable in
installments. The Plan Administrator will determine the terms of any such
promissory note. However, the maximum amount of financing provided any
participant may not exceed the cash consideration payable for the issued shares
plus all applicable taxes incurred in connection with the acquisition of the
shares. Any such promissory note may be subject to forgiveness in whole or in
part, at the discretion of the Plan Administrator, over the participant's period
of service.
 
     Special Tax Election. The Plan Administrator may provide one or more
holders of options or unvested shares with the right to have the Company
withhold a portion of the shares otherwise issuable to such individuals in
satisfaction of the tax liability incurred by such individuals in connection
with the exercise of those options or the vesting of those shares.
Alternatively, the Plan Administrator may allow such individuals to deliver
previously acquired shares of Common Stock in payment of such tax liability.
 
                                        7
<PAGE>   11
 
AMENDMENT AND TERMINATION
 
     The Board may amend or modify the Option Plan in any or all respects
whatsoever subject to any required stockholder approval. The Board may terminate
the Option Plan at any time, and the Option Plan will in all events terminate on
August 1, 2005.
 
STOCK AWARDS
 
     The table below shows, as to each of the Company's executive officers named
in the Summary Compensation Table elsewhere in this Proxy Statement and the
various indicated individuals and groups, the number of shares of Common Stock
subject to options granted under the Option Plan between July 1, 1996 and
September 30, 1997, together with the weighted average exercise price payable
per share.
 
                              OPTION TRANSACTIONS
 
<TABLE>
<CAPTION>
                                                                OPTIONS GRANTED     WEIGHTED AVERAGE
                            NAME                               (NUMBER OF SHARES)    EXERCISE PRICE
- -------------------------------------------------------------  ------------------   ----------------
<S>                                                            <C>                  <C>
Richard A. Miller, President and Chief Executive Officer.....         60,000             $15.75
Marc L. Steuer, Vice President, Business Development and
  Chief Financial Officer....................................         55,000             $16.43
William C. Dow, Ph.D., Vice President, Chemical Research and
  Development................................................         30,000             $15.75
Cheryl B. Jaszewski, Vice President, Finance and
  Administration.............................................         20,000             $15.75
All current executive officers as a group (4 persons)........        165,000             $15.98
All current non-employee Board members as a group............         25,000             $16.00
All employees, including current officers who are not
  executive officers as a group (27 persons).................        183,501             $16.44
</TABLE>
 
FEDERAL TAX CONSEQUENCES OF OPTIONS
 
     Options granted under the Option Plan may be either incentive stock options
which satisfy the requirements of Section 422 of the Internal Revenue Code or
non-statutory options which are not intended to satisfy such requirements. The
Federal income tax treatment for the two types of options differ as follows:
 
     Incentive Options. No taxable income is recognized by the optionee at the
time of the option grant, and no taxable income is generally recognized at the
time the option is exercised. The optionee will, however, recognize regular
taxable income in the year in which the purchased shares are sold or otherwise
made the subject of disposition. For Federal tax purposes, dispositions are
divided into two categories: (i) qualifying and (ii) disqualifying. A qualifying
disposition occurs if the sale or other disposition is made after the optionee
has held the shares for more than two years after the option grant date and more
than one year after the exercise date. If either of these two holding periods is
not satisfied, then a disqualifying disposition will result.
 
     If the optionee makes a disqualifying disposition of the purchased shares,
then the Company will be entitled to an income tax deduction, for the taxable
year in which such disposition occurs, equal to the excess of (i) the fair
market value of such shares on the option exercise date over (ii) the exercise
price paid for the shares. In no other instance will the Company be allowed a
deduction with respect to the optionee's disposition of the purchased shares.
 
     Non-statutory Options. No taxable income is recognized by an optionee upon
the grant of a non-statutory option. The optionee will in general recognize
ordinary income in the year in which the option is exercised equal to the excess
of the fair market value of the purchased shares at the date of exercise over
the exercise price, and the optionee will be required to satisfy the tax
withholding requirements applicable to such income.
 
     If the shares acquired upon exercise of the non-statutory option are
subject to repurchase by the Company, at the original exercise price paid per
share, in the event the optionee's service terminates prior to
 
                                        8
<PAGE>   12
 
vesting in the shares, then the optionee will not recognize any taxable income
at the time of exercise. The optionee will have to report as ordinary income, as
and when the Company's repurchase right lapses, an amount equal to the
difference between the fair market value of the shares on the date the
repurchase right lapses and the option exercise price paid for those shares. The
optionee may, however, elect under Section 83(b) of the Internal Revenue Code to
include as ordinary income in the year of exercise an amount equal to the
difference between the fair market value of the purchased shares on the date of
exercise (determined as if the shares were not subject to the Company's
repurchase right) and the option exercise price paid for the shares. If the
Section 83(b) election is made, the optionee will not recognize any additional
income as and when the Company's repurchase right lapses.
 
     The Company will be entitled to a business expense deduction equal to the
amount of ordinary income recognized by the optionee in connection with the
exercise of the non-statutory option. The deduction will in general be allowed
for the taxable year of the Company in which such ordinary income is recognized
by the optionee.
 
     Stock Appreciation Rights. An optionee who is granted a stock appreciation
right will recognize ordinary income in the year of exercise equal to the amount
of the appreciation distribution. The Company will be entitled to an income tax
deduction equal to such distribution for the taxable year in which the ordinary
income is recognized by the optionee.
 
     Deductibility of Executive Compensation. The Company anticipates that any
compensation deemed paid by it in connection with disqualifying dispositions of
incentive stock option shares or exercises of non-statutory options granted with
exercise prices equal to the fair market value of the shares on the grant date
will qualify as performance-based compensation for purposes of Code Section
162(m) and will not have to be taken into account for purposes of the $1 million
limitation per covered individual on the deductibility of the compensation paid
to certain executive officers of the Company.
 
ACCOUNTING TREATMENT
 
     Option grants or stock issuances to employees with exercise or issue prices
less than the fair market value of the shares on the grant or issue date will
result in a compensation expense to the Company's earnings equal to the
difference between the exercise or issue price and the fair market value of the
shares on the grant or issue date. Such expense will be recognized by the
Company over the period that the option shares or issued shares are to vest.
Option grants or stock issuances at 100% of fair market value will not result in
any charge to the Company's earnings, but the Company must disclose, in
pro-forma statements to the Company's financial statements, the impact those
options would have upon the Company's reported earnings were the value of those
options at the time of grant treated as compensation expense. Whether or not
granted at a discount, the number of outstanding options may be a factor in
determining the Company's earnings per share on a fully-diluted basis. Options
or stock appreciation rights granted other than to employees and Board members
will result in a charge to the Company's earnings based upon the Black-Schoales.
 
     Should one or more optionees be granted stock appreciation rights which
have no conditions upon exercisability other than a service or employment
requirement, then such rights will result in compensation expense to the
Company's earnings.
 
NEW PLAN BENEFITS
 
     As of September 30, 1997, no stock options have been granted on the basis
of the 500,000-share increase for which stockholder approval is sought as part
of this Proposal Two.
 
STOCKHOLDER APPROVAL
 
     The affirmative vote of a majority of the outstanding voting shares of the
Company present or represented and entitled to vote at the Annual Meeting is
required for approval of the amendment to the Option Plan which will increase
the maximum number of shares of Common Stock authorized for issuance over the
term of the Option Plan by an additional 500,000 shares. Should such stockholder
approval not be obtained, then the 500,000-share increase to the share reserve
will not be implemented and the maximum number of shares
 
                                        9
<PAGE>   13
 
of Common Stock for which any one individual may be granted options and
separately exercisable stock appreciation rights will remain at 333,334. In
addition, members of the Plan Administrator will not become eligible to
participate in the Option Plan, and any unvested shares repurchased by the
Company at the option exercise price paid per share will not be added back to
the share reserve for reissuance. The Option Plan will, however, continue to
remain in effect, and option grants may continue to be made pursuant to the
provisions of the Option Plan in effect prior to the amendment summarized in
this Proposal Two, until the available reserve of Common Stock as last approved
by the stockholders has been issued pursuant to option grants made under the
Option Plan.
 
     THE BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE IN FAVOR OF
THE AMENDMENT TO THE COMPANY'S 1995 STOCK OPTION PLAN.
 
                        PROPOSAL THREE -- APPROVAL OF AN
                   AMENDMENT TO EMPLOYEE STOCK PURCHASE PLAN
 
     The Company's stockholders are also being asked to approve an amendment to
the Employee Stock Purchase Plan (the "Purchase Plan") to increase the number of
shares of the Company's Common Stock authorized for issuance under the Purchase
Plan by an additional 50,000 shares.
 
     The Purchase Plan was originally adopted by the Board of Directors on
August 2, 1995, approved by the Company's stockholders on September 11, 1995 and
became effective on October 23, 1995. The Purchase Plan is intended to provide
eligible employees of the Company and its participating affiliates with the
opportunity to acquire a proprietary interest in the Company through
participation in a payroll-deduction based employee stock purchase plan designed
to operate in compliance with Section 423 of the Internal Revenue Code.
 
     The Board amended the Purchase Plan on September 11, 1997, subject to
stockholder approval at the Annual Meeting. The Board believes that it is in the
best interests of the Company to continue a program of stock ownership for the
Company's employees in order to provide them with a meaningful opportunity to
acquire a substantial proprietary interest in the Company and thereby encourage
such individuals to remain in the Company's service and more closely align their
interests with those of the stockholders.
 
     The following is a summary of the principal features of the Purchase Plan
as amended through September 11, 1997. The summary, however, does not purport to
be a complete description of all the provisions of the Purchase Plan. Any
stockholder of the Company who wishes to obtain a copy of the actual plan
document may do so upon written request to the Corporate Secretary at the
Company's principal executive offices in Sunnyvale, California.
 
SHARE RESERVE
 
     A total of 100,000 shares of Common Stock have been reserved for issuance
under the Purchase Plan, inclusive of the 50,000 share increase for which
stockholder approval is sought under this Proposal Three. In the event any
change is made to the outstanding shares of Common Stock by reason of any
recapitalization, stock dividend, stock split, combination of shares, exchange
of shares or other change in corporate structure effected without the Company's
receipt of consideration, appropriate adjustments will be made to (i) the class
and maximum number of securities issuable under the Purchase Plan, including the
class and maximum number of securities issuable per participant on any one
purchase date, and (ii) the class and number of securities subject to each
outstanding purchase right and the purchase price payable per share thereunder.
 
ADMINISTRATION
 
     The Purchase Plan will be administered by the Compensation Committee of the
Board. Such committee, as Plan Administrator, will have full authority to adopt
such rules and procedures as it may deem necessary for proper plan
administration and to interpret the provisions of the Purchase Plan. All costs
and expenses incurred in plan administration will be paid by the Company without
charge to participants.
 
                                       10
<PAGE>   14
 
OFFERING PERIODS AND PURCHASE PERIODS
 
     The Purchase Plan is comprised of a series of successive offering periods,
each with a maximum duration (not to exceed twenty-four (24) months) designated
by the Plan Administrator prior to the start date. The current offering period
began on November 1, 1997 and will end on October 31, 1999, and the next
offering period is scheduled to commence on November 1, 1999.
 
     Shares will be purchased during the offering period at successive
semi-annual intervals. Each such interval will constitute a purchase period.
Purchase periods under the Purchase Plan will begin on the first business day in
May and November each year and end on the last business day in the immediately
succeeding October and April, respectively, each year. The first purchase period
under the current offering period began on November 1, 1997 and will end on the
last business day in April 1998.
 
ELIGIBILITY
 
     Any individual who customarily works for more than twenty (20) hours per
week for more than five (5) months per calendar year in the employ of the
Company or any participating affiliate will become eligible to participate in an
offering period on the start date of any purchase period (within that offering
period) which begins on or after such individual's completion of ninety (90)
days of continuous service with the Company or any affiliate. The date such
individual enters the offering period will be designated his or her entry date
for purposes of that offering period.
 
     Participating affiliates include any parent or subsidiary corporations of
the Company, whether now existing or hereafter organized, which elect, with the
approval of the Plan Administrator, to extend the benefits of the Purchase Plan
to their eligible employees.
 
     As of September 30, 1997, approximately 37 employees, including three
executive officers, were eligible to participate in the Purchase Plan.
 
PURCHASE PROVISIONS
 
     Each participant will be granted a separate purchase right for each
offering period in which he or she participates. The purchase right will be
granted on his or her entry date into that offering period and will be
automatically exercised on the last business day of each purchase period within
that offering period on which he or she remains an eligible employee.
 
     Each participant may authorize period payroll deductions in any multiple of
1% of his or her total cash earnings per pay period, up to a maximum of ten
percent (10%).
 
     On the last business day of each purchase period, the accumulated payroll
deductions of each participant will automatically be applied to the purchase of
whole shares of Common Stock at the purchase price in effect for the participant
for that purchase period. However, the maximum number of shares of Common Stock
a participant may purchase on any purchase date may not exceed 1,000 shares.
 
PURCHASE PRICE
 
     The purchase price per share at which Common Stock will be purchased on the
participant's behalf on each purchase date within the offering period will be
equal to eighty-five percent (85%) of the lower of (i) the fair market value per
share of Common Stock on the participant's entry date into that offering period
or (ii) the fair market value per share of Common Stock on that purchase date.
However, for each participant whose entry date is other than the start date of
the offering period, the clause (i) amount will not be less than the fair market
value per share of Common Stock on the start date of that offering period.
 
VALUATION
 
     The fair market value per share of Common Stock on any relevant date will
be deemed equal to the closing selling price per share on such date on the
Nasdaq National Market. On September 30, 1997, the fair market value per share
of Common Stock was $24.75 per share.
 
                                       11
<PAGE>   15
 
SPECIAL LIMITATIONS
 
     The Purchase Plan imposes certain limitations upon a participant's rights
to acquire Common Stock, including the following limitations:
 
          (i) No purchase right may be granted to any individual who owns stock
     (including stock purchasable under any outstanding purchase rights)
     possessing 5% or more of the total combined voting power or value of all
     classes of stock of the Company of any of its affiliates.
 
          (ii) No purchase right granted to a participant may permit such
     individual to purchase Common Stock at a rate greater than $25,000 worth of
     such Common Stock (valued at the time such purchase right is granted) for
     each calendar year the purchase right remains outstanding at any time.
 
TERMINATION OF PURCHASE RIGHTS
 
     The purchase right will immediately terminate upon the participant's loss
of eligible employee status or upon his or her affirmative withdrawal from the
offering period. The payroll deductions collected for the purchase period in
which the purchase right terminates may, at the participant's election, be
immediately refunded or applied to the purchase of Common Stock at the end of
that purchase period.
 
STOCKHOLDER RIGHTS
 
     No participant will have any stockholder rights with respect to the shares
of Common Stock covered by his or her purchase right until the shares are
actually purchased on the participant's behalf. No adjustment will be made for
dividends, distributions or other rights for which the record date is prior to
the date of such purchase.
 
ASSIGNABILITY
 
     No purchase right will be assignable or transferable other than in
connection with the participant's death and will be exercisable only by the
participant during his or her lifetime.
 
ACQUISITION
 
     Should the Company be acquired by merger or asset sale during an offering
period, all outstanding purchase rights will automatically be exercised
immediately prior to the effective date of such acquisition. The purchase price
will be 85% of the lower of (i) the fair market value per share of Common Stock
on the participant's entry date into that offering period or (ii) the fair
market value per share of Common Stock immediately prior to such acquisition.
However, the clause (i) amount will not, for any participant whose entry date
for the offering period is other than the start date of that offering period, be
less than the fair market value per share of Common Stock on such start date.
 
AMENDMENT AND TERMINATION
 
     The Purchase Plan will terminate upon the earliest to occur of (i) the last
business day in October, 2005, (ii) the date on which all available shares are
issued or (iii) the date on which all outstanding purchase rights are exercised
in connection with an acquisition of the Company.
 
     The Board of Directors may at any time alter, suspend or discontinue the
Purchase Plan. However, the Board of Directors may not, without stockholder
approval, (i) materially increase the number of shares issuable under the
Purchase Plan or the number purchasable per participant on any one purchase
date, except in connection with certain changes in the Company's capital
structure, (ii) alter the purchase price formula so as to reduce the purchase
price, (iii) materially increase the benefits accruing to participants or (iv)
materially modify the requirements for eligibility to participate in the
Purchase Plan.
 
                                       12
<PAGE>   16
 
STOCK ISSUANCES
 
     The table below shows, as to each of the executive officers named in the
Summary Compensation Table elsewhere in this Proxy Statement and the various
indicated groups, the following information with respect to transactions under
the Purchase Plan effected during the period from July 1, 1996 to September 30,
1997: (i) the number of shares of Common Stock purchased under the Purchase Plan
during that period and (ii) the weighted average purchase price paid per share
of Common Stock in connection with such purchases.
 
<TABLE>
<CAPTION>
                                                               NUMBER OF
                                                                SHARES          WEIGHTED AVERAGE
                             NAME                              PURCHASED         PURCHASE PRICE
    ------------------------------------------------------  ---------------     ----------------
    <S>                                                     <C>                 <C>
    Cheryl B. Jaszewski, Vice President, Finance and
      Administration......................................        1,132              $10.20
    All current executive officers as a group (1
      person).............................................        1,132              $10.20
    All employees, including current officers who are not
      executive officers, as a group (31 persons).........       13,425              $10.52
</TABLE>
 
NEW PLAN BENEFITS
 
     As of September 30, 1997, no purchase rights had been granted under the
Purchase Plan on the basis of the 50,000-share increase subject to approval
under this Proposal Three.
 
FEDERAL TAX CONSEQUENCES
 
     The Purchase Plan is intended to be an "employee stock purchase plan"
within the meaning of Section 423 of the Internal Revenue Code. Under a plan
which so qualifies, no taxable income will be recognized by a participant, and
no deductions will be allowable to the Company, in connection with the grant or
the exercise of an outstanding purchase right. Taxable income will not be
recognized until there is a sale or other disposition of the shares acquired
under the Purchase Plan or in the event the participant should die while still
owning the purchased shares.
 
     If the participant sells or otherwise disposes of the purchased shares
within two (2) years after his or her entry date into the offering period in
which such shares were acquired or within one (1) year after the actual purchase
date of those shares, then the participant will recognize ordinary income in the
year of sale or disposition equal to the amount by which the fair market value
of the shares on the purchase date exceeded the purchase price paid for those
shares, and the Company will be entitled to an income tax deduction, for the
taxable year in which such sale or disposition occurs, equal in amount to such
excess.
 
     If the participant sells or disposes of the purchased shares more than two
(2) years after his or her entry date into the offering period in which such
shares were acquired and more than one (1) one year after the actual purchase
date of those shares, then the participant will recognize ordinary income in the
year of sale or disposition equal to the lesser of (i) the amount by which the
fair market value of the shares on the sale or disposition date exceeded the
purchase price paid for those shares or (ii) 15% of the fair market value of the
shares on his or her entry date into the offering period, and any additional
gain upon the disposition will be taxed as a long-term capital gain. The Company
will not be entitled to any income tax deduction with respect to such sale or
disposition.
 
     If the participant still owns the purchased shares at the time of death,
the lesser of (i) the amount by which the fair market value of the shares on the
date of death exceeds the purchase price or (ii) 15% of the fair market value of
the shares on his or her Entry Date into the offering period in which those
shares were acquired will constitute ordinary income in the year of death.
 
ACCOUNTING TREATMENT
 
     Under current accounting rules, the issuance of shares of Common Stock
under the Purchase Plan will not result in a compensation expense chargeable
against the Company's operations. However, the Company must disclose, in notes
to the Company's financial statements, the pro forma impact which the purchase
rights
 
                                       13
<PAGE>   17
 
granted under the Purchase Plan would have upon the Company's reported earnings
were the value of those purchase rights treated as compensation expense.
 
STOCKHOLDER APPROVAL
 
     The affirmative vote of a majority of the outstanding voting shares of the
Company present or represented and entitled to vote at the Annual Meeting is
required for amendment to increase the number of shares issuable under the
Purchase Plan by an additional 50,000 shares. If such stockholder approval is
not be obtained, then any purchase rights granted on the basis of the 50,000
share increase will terminate. The Purchase Plan will, however, continue to
remain in effect, and purchase rights may be granted and stock purchases may
continue to be made pursuant to the provisions of that plan until the available
reserve of Common Stock under that plan as last approved by the stockholders has
been issued.
 
     THE BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE FOR THE
AMENDMENT OF THE PURCHASE PLAN.
 
                   PROPOSAL FOUR -- RATIFICATION OF SELECTION
                           OF INDEPENDENT ACCOUNTANTS
 
     The Board has appointed the firm of Price Waterhouse LLP, independent
accountants, to audit the financial statements of the Company for the fiscal
year ending June 30, 1998, and is asking the stockholders to ratify this
appointment.
 
     In the event the stockholders fail to ratify the appointment, the Board
will reconsider its selection. Even if the selection is ratified, the Board in
its discretion may direct the appointment of a different independent accounting
firm at any time during the year if the Board feels that such a change would be
in the best interest of the Company and its stockholders. The affirmative vote
of the holders of a majority of the Company's Common Stock present or
represented by Proxy at the Annual Meeting and entitled to vote is required to
ratify the selection of Price Waterhouse LLP.
 
     Price Waterhouse LLP has served as independent auditors to the Company for
the fiscal year ended June 30, 1997. A representative of Price Waterhouse LLP is
expected to be present at the Annual Meeting to respond to appropriate
questions, and will be given the opportunity to make a statement if he or she so
desires.
 
     THE BOARD RECOMMENDS THAT THE STOCKHOLDERS VOTE IN FAVOR OF THE
RATIFICATION OF THE SELECTION OF PRICE WATERHOUSE LLP TO SERVE AS THE COMPANY'S
INDEPENDENT ACCOUNTANTS FOR THE FISCAL YEAR ENDING JUNE 30, 1998.
 
                                       14
<PAGE>   18
 
                  EXECUTIVE COMPENSATION AND OTHER INFORMATION
 
SUMMARY OF CASH AND CERTAIN OTHER COMPENSATION
 
     The following table sets forth certain compensation earned during the
fiscal year ended June 30, 1997, for services rendered in all capacities to the
Company and its subsidiaries, by (i) the Company's Chief Executive Officer, (ii)
the three other highest paid executive officers whose salary and bonus for
fiscal 1997 were in excess of $100,000 and (iii) one other executive officer who
resigned during that fiscal year. The individuals named in the table will be
hereinafter referred to as the "Named Executive Officers."
 
                           SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                           LONG-TERM
                                                                         COMPENSATION
                                                                     ---------------------
                                                         ANNUAL
                                                      COMPENSATION          AWARDS
                                                      ------------   ---------------------    ALL OTHER
                                                         SALARY      SECURITIES UNDERLYING   COMPENSATION
         NAME AND PRINCIPAL POSITION           YEAR      ($)(1)        OPTIONS/SARS (#)          ($)
- ---------------------------------------------  ----   ------------   ---------------------   ------------
<S>                                            <C>    <C>            <C>                     <C>
Richard A. Miller                              1997      229,833             60,000                 --
  President and Chief                          1996      215,865            246,667                 --
  Executive Officer
 
Marc L. Steuer                                 1997      199,200             55,000                 --
  Vice President, Business Development         1996      181,827             80,000                 --
  and Chief Financial Officer
 
Stuart W. Young, M.D.(2)                       1997      150,816                 --             90,273
  Vice President, Medical Research             1996      160,303             33,334                 --
 
William C. Dow, Ph.D.                          1997      140,237             30,000                 --
  Vice President, Chemical Research and        1996      130,098             67,667                 --
  Development
 
Cheryl B. Jaszewski                            1997      117,987             20,000                 --
  Vice President, Finance and Administration   1996      110,375             43,334                 --
</TABLE>
 
- ---------------
(1) Includes amounts earned but not paid in the fiscal year ended June 30, 1997.
 
(2) Dr. Young resigned from the Company effective as of June 8, 1997. The amount
    reported under "All Other Compensation" for fiscal 1997 represents
    consulting fees earned by Dr. Young since the date of his resignation.
 
                                       15
<PAGE>   19
 
STOCK OPTIONS, EXERCISES AND HOLDINGS
 
     The following table provides certain information regarding stock options
granted to the Named Executive Officers during the fiscal year ended June 30,
1997. Except for the limited stock appreciation rights described in footnote (1)
below, no stock appreciation rights were granted during such fiscal year to the
Named Executive Officers.
 
                       OPTION GRANTS IN LAST FISCAL YEAR
 
<TABLE>
<CAPTION>
                                                                                       POTENTIAL REALIZABLE
                                 INDIVIDUAL GRANTS                                       VALUE AT ASSUMED
- ------------------------------------------------------------------------------------      ANNUAL RATES OF
                                 NUMBER OF                                                  STOCK PRICE
                                SECURITIES      PERCENTAGE OF                              APPRECIATION
                                UNDERLYING      TOTAL OPTIONS   EXERCISE                FOR OPTION TERM(5)
                              OPTIONS GRANTED    GRANTED TO     PRICE PER   EXPIRATION ---------------------
            NAME                  (1)(2)        EMPLOYEES(3)    SHARE(4)      DATE        5%         10%
- ----------------------------  ---------------   -------------   ---------   --------   --------   ----------
<S>                           <C>               <C>             <C>         <C>        <C>        <C>
Richard A. Miller, M.D......       60,000            17.0%       $ 15.75    06/11/07   $594,305   $1,506,089
Marc L. Steuer..............       15,000             4.3%       $ 18.25    09/18/06   $172,160   $  436,287
                                   40,000            11.0%       $ 15.75    06/11/07   $396,204   $1,004,058
Stuart W. Young, M.D.(6)....           --              --             --          --         --           --
William C. Dow, Ph.D........       30,000             8.3%       $ 15.75    06/11/07   $297,153   $  753,043
Cheryl B. Jaszewski.........       20,000             5.6%       $ 15.75    06/11/07   $198,102   $  502,029
</TABLE>
 
- ---------------
 
(1) Each option includes a limited stock appreciation right that allows the
    optionee to surrender his or her option with such a right in effect for six
    months, to the extent exercisable for vested shares of Common Stock, upon
    the successful completion of a hostile tender offer for more than 50% of the
    Company's outstanding securities. In return, the optionee will be entitled
    to a cash distribution from the Company in an amount per surrendered option
    share equal to the highest price per share of Common Stock paid in the
    tender offer less the exercise price payable per share.
 
(2) The dates on which the options were granted are as follows:
 
<TABLE>
<CAPTION>
                                NAME                       NUMBER SHARES   GRANT DATE
            ---------------------------------------------  -------------   ----------
            <S>                                            <C>             <C>
            Richard A. Miller, M.D.......................      60,000        06/12/97
            Marc L. Steuer...............................      15,000        09/19/96
                                                               40,000        06/12/97
            William C. Dow, Ph.D.........................      30,000        06/12/97
            Cheryl B. Jaszewski..........................      20,000        06/12/97
</TABLE>
 
     The option for 60,000 shares granted to Dr. Miller on June 12, 1997 is
     immediately exercisable subject to the Company's right to repurchase any
     unvested shares upon termination of Dr. Miller's services. Such option will
     vest in a series of 36 successive equal monthly installments beginning on
     January 1, 2000.
 
     The option for 15,000 shares granted to Mr. Steuer on September 19, 1996
     vests in 12 successive equal monthly installments over the one year period
     beginning January 1, 1999.
 
     The option for 40,000 shares granted to Mr. Steuer on June 12, 1997 is
     immediately exercisable. Such option will vest as follows: (i) 10,000
     shares will vest in 120 successive equal monthly installments with
     acceleration based upon meeting fiscal year 1998 goals; (ii) 5,000 shares
     will vest in 12 successive equal monthly installments over the one year
     period beginning January 1, 2000; (iii) 10,000 shares will vest in 12
     successive equal monthly installments over the one year period beginning
     January 1, 2001; and (iv) 15,000 shares will vest in 12 successive equal
     monthly installments over the one year period beginning January 1, 2002.
 
                                       16
<PAGE>   20
 
     The option for 30,000 shares granted to Dr. Dow on June 12, 1997 is
     immediately exercisable. Such option shall vest as follows: (i) 4,000
     shares shall vest in 12 successive equal monthly installments over the one
     year period beginning January 1, 1999; (ii) 6,000 shares shall vest in 12
     successive equal monthly installments over the one year period beginning
     January 1, 2000; and (iii) 20,000 shares shall vest in 24 successive equal
     monthly installments over the two year period beginning January 1, 2001.
 
     The option for 20,000 shares granted to Ms. Jaszewski on June 12, 1997 is
     immediately exercisable. Such option will vest as follows: (i) 4,000 shares
     will vest in 24 successive equal monthly installments over the two year
     period beginning January 1, 1999 and (ii) 16,000 shares will vest in 24
     successive equal monthly installments over the two year period beginning
     January 1, 2001.
 
     Each of the granted options will immediately become exercisable for all of
     the option shares in the event of certain acquisitions or hostile
     take-overs of the Company as described in Proposal Two. Each option has a
     maximum term of ten years, subject to earlier termination in the event of
     the optionee's cessation of service with the Company.
 
(3) Based on an aggregate of approximately 359,000 options granted to employees
    in fiscal 1997, including options granted to the Named Executive Officers.
 
(4) The exercise price may be paid in cash, in shares of the Company's Common
    Stock valued at fair market value on the exercise date or through a cashless
    exercise procedure involving a same day sale of the purchased shares. The
    Company may also finance the option exercise price as described in Proposal
    Two. The Plan Administrator has the discretionary authority to reprice
    outstanding options under the Plan through the cancellation of those options
    and the grant of replacement options with an exercise price equal to the
    lower fair market value of the option shares on the regrant date.
 
(5) Potential realizable value is based on the assumption that the price per
    share of Common Stock appreciates at the assumed annual rate of stock
    appreciation for the option term. The assumed 5% and 10% annual rates are
    set forth in accordance with the rules and regulations adopted by the
    Securities and Exchange Commission and do not represent the Company's
    estimate of stock price appreciation. There can be no assurance that the
    assumed 5% and 10% annual rates of appreciation (compounded annually) will
    actually be realized over the term of the option. Unless the market price of
    the Common Stock appreciates over the option term, no value will be realized
    from the option grants made to the executive officers.
 
(6) Dr. Young resigned from the Company effective as of June 8, 1997.
 
                                       17
<PAGE>   21
 
OPTION HOLDINGS
 
     The table below sets forth certain information concerning the exercise of
options during the fiscal year ending June 30, 1997 by the Named Executive
Officers and unexercised options held as of the end of such year by such
individuals. No stock appreciation rights were exercised by the Named Executive
Officers during such fiscal year, and, except to the extent described in
footnote (1) to the Option Grants table above, no stock appreciation rights were
held by such individuals at the end of such fiscal year.
 
                   AGGREGATED OPTION EXERCISES IN FISCAL 1997
                     AND 1997 FISCAL YEAR-END OPTION VALUES
 
<TABLE>
<CAPTION>
                                                             NO. OF SECURITIES
                                                          UNDERLYING UNEXERCISED         VALUE OF UNEXERCISED
                                                             OPTIONS AT FISCAL           IN-THE-MONEY OPTIONS
                                SHARES                           YEAR END                AT FISCAL YEAR END(1)
                              ACQUIRED ON   VALUE       ---------------------------   ---------------------------
            NAME               EXERCISE    REALIZED     EXERCISABLE   UNEXERCISABLE   EXERCISABLE   UNEXERCISABLE
- ----------------------------  -----------  --------     -----------   -------------   -----------   -------------
<S>                           <C>          <C>          <C>           <C>             <C>           <C>
Richard A. Miller, M.D......         --          --        65,667        241,000       $ 352,000      $ 821,336
Marc L. Steuer..............         --          --        77,695        150,639       $ 804,267      $ 612,408
Stuart W. Young, M.D.(2)....     18,001    $279,241(3)     11,109         22,224       $  88,872      $ 177,792
William C. Dow, Ph.D........     20,000    $375,250(3)     31,611         92,723       $ 344,679      $ 214,619
Cheryl B. Jaszewski.........         --          --        13,667         59,667       $ 110,337      $ 113,835
</TABLE>
 
- ---------------
 
(1) Determined by subtracting the exercise price from the market price of the
    Common Stock on June 30, 1997 ($15.50).
 
(2) Dr. Young resigned from the Company effective as of June 8, 1997.
 
(3) Based upon fair market value on date of exercise less exercise price.
 
EMPLOYMENT CONTRACTS AND CHANGE IN CONTROL ARRANGEMENTS
 
     In May 1992, the Company entered into an employment letter agreement with
William C. Dow, which remains in effect unless and until terminated by either
the Company or Dr. Dow at any time and for any reason, with or without cause.
During the fiscal year ended June 30, 1997, the Company paid Dr. Dow $140,237
under the agreement.
 
     In June 1992, the Company entered into an employment agreement with Richard
A. Miller which either party may terminate at any time upon 90 days' prior
written notice of an intent to terminate. During the fiscal year ended June 30,
1997, the Company paid Dr. Miller $229,833 under the agreement.
 
     In October 1992, the Company entered into an employment agreement with
Cheryl B. Jaszewski, which remains in effect unless and until terminated by
either the Company or Ms. Jaszewski at any time and for any reason, with or
without cause. During the fiscal year ended June 30, 1997, the Company paid Ms.
Jaszewski $117,987 under the agreement.
 
     In April 1993, the Company entered into an employment agreement with Stuart
W. Young which either party may terminate at any time upon 30 days written
notice of intent to terminate. During the fiscal year ended June 30, 1997, the
Company paid Dr. Young $159,800 under the agreement. This employment agreement
was terminated upon Dr. Young's resignation. In May 1997, the Company entered
into an agreement with Dr. Young. Under the terms of the agreement, Dr. Young is
to be paid a monthly consulting fee of $13,900.00 through August 30, 1997 as
well as severance payments totaling $41,730.00 to be paid in September, October
and November 1997. Furthermore, Dr. Young continued to vest in certain
outstanding options through the termination of the consulting period.
 
     In October 1994, the Company entered into an employment agreement with Marc
L. Steuer, which remains in effect unless and until terminated by either the
Company or Mr. Steuer at any time and for any
 
                                       18
<PAGE>   22
 
reason, with or without cause. During the fiscal year ended June 30, 1997, the
Company paid Mr. Steuer $199,200 under the agreement.
 
     The Company has entered into agreements with each of Dr. Miller, Mr.
Steuer, Dr. Dow and Ms. Jaszewski that provide for certain payments and
accelerated vesting of the shares of common stock subject to the outstanding
options held by each officer under the Company's 1995 Stock Option Plan in the
event of certain changes in control of the Company or a subsequent termination
of employment. In the event of such officer's involuntary termination within 36
months following the change in control, the officer will be entitled to receive
severance payments for a period of 12 months in an aggregate amount equal to the
officer's base salary at the time of termination plus the bonus paid to the
officer in the fiscal year preceding the year of termination. The payments will
be made in installments over the 12-month period unless the officer elects to
receive a lump-sum payment equal to the present value of the installment
payments. In addition, in the event of a change in control, all outstanding
options held by the officer which would fully vest or become fully exercisable
at least 18 months after the change in control will accelerate as follows: 50%
of the unvested or unexercisable portion immediately upon the change in control;
25% of the portion unexercisable or unvested at the time of the change in
control one year after the change in control (if the officer is then still
employed by the Company or its successor); and 25% of the portion unexercisable
or unvested at the time of the change in control 18 months after a change in
control (if the officer is then still employed by the Company or its successor).
All Options held by the officer at the time of a change in control which
otherwise become fully exercisable or fully vest within 18 months following the
change in control will become exercisable and vest in accordance with the
following schedule: 50% of the previously unexercisable or unvested portion
immediately upon the change in control; the remaining portion will continue to
become exercisable and vest in accordance with the exercise/vesting schedule
applicable to those options at the time of the change in control. Similarly, any
repurchase rights exercisable by the Company with respect to shares of Common
Stock held by the officer will lapse depending upon when the repurchase rights
would have otherwise lapsed. In the event of the officer's involuntary
termination during the 18 month period after the change in control, all
previously unexercisable options (including options which did not accelerate at
the time of the change in control) will become immediately exercisable and the
repurchase rights will lapse as to all shares then held by the officer.
 
     Under the Option Plan, the Plan Administrator has the authority to
accelerate outstanding options in the event of certain changes in control of the
Company.
 
COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION
 
     Decisions on compensation matters relating to the Company's President and
Chief Executive Officer, Richard A. Miller, and the Company's other executive
officers are generally made by the Compensation Committee. The Compensation
Committee also administers the Company's 1995 Stock Option Plan (the "Plan")
under which grants may be made to executive officers and other key employees.
The Compensation Committee has furnished the following report on the
compensation established for Dr. Miller and the Company's other executive
officers for the period from July 1, 1996 to June 30, 1997.
 
     In May 1996, the Compensation Committee set the compensation payable to Dr.
Miller for the 12-month period ending April 30, 1997. Similarly, in June 1997,
the Compensation Committee set the compensation payable to Dr. Miller for the
12-month period ending April 30, 1998. Dr. Miller in turn recommended, subject
to the Compensation Committee's review and approval, the compensation to be paid
for such 12-month period to the Company's other executive officers. For those
executive officers, the Compensation Committee had previously established
performance factors to be considered by Dr. Miller in making his recommendations
with respect to the compensation level to be in effect for each such officer.
Dr. Miller provided the Compensation Committee with his evaluation of the
performance of each officer with respect to those factors and his recommendation
as to the compensation to be paid to that individual on the basis of such
performance. The Compensation Committee reviewed and approved the
recommendations of Dr. Miller.
 
     General Compensation Policy.  The Compensation Committee's overall policy
as to executive compensation is to ensure that an appropriate relationship
exists between the total compensation package established for each executive
officer and the creation of stockholder value, while at the same time assuring
that
 
                                       19
<PAGE>   23
 
compensation is sufficiently competitive to motivate and retain key executives.
In furtherance of this goal, executive compensation is structured so as to
integrate competitive levels of annual base salary with discretionary stock
options based upon individual and corporate performance. This annual cash
compensation, together with the payment of equity incentives in the form of
stock option grants, is designed to attract and retain qualified executives and
to ensure that such executives have a continuing stake in the long-term success
of the Company.
 
     Factors.  Since the Company is in the development stage, the use of
traditional performance standards (such as profit levels and return on equity)
are not appropriate in evaluating the performance of the executive officers. In
particular, the unique nature of the biotechnology industry, specifically the
absence of revenues and the fact that the Company's stock performance is often
more a consequence of larger market forces than of actual Company achievements,
makes it impossible to tie performance objectives to standard financial
considerations. The primary factors which were considered in establishing the
components of each executive officer's compensation package for the 1997 fiscal
year are summarized below. The Compensation Committee may, however, in its
discretion apply entirely different factors, such as different measures of
strategic performance, for future fiscal years.
 
        - BASE SALARY.  When establishing or reviewing base compensation levels
for each executive officer, the Committee considers numerous factors, including
the qualifications of the executive and his or her level of relevant experience,
strategic goals for which the executive has responsibility, specific
accomplishments of the executive during the last fiscal year and the
compensation levels in effect at companies in the Company's industry which
compete with the Company for business and executive talent.
 
          Base salaries are reviewed annually, and adjustments to each executive
officer's base salary are made to reflect individual performance and salary
increases effected by the peer group companies. A major objective, accordingly,
is to have base salary levels commensurate with those of comparable positions
with the peer group companies, given the level of seniority and skills possessed
by the executive officer in question and the Committee's assessment of such
executive's performance over the year.
 
        - LONG-TERM INCENTIVE COMPENSATION.  The Compensation Committee has the
authority under the Plan to provide executives and other key employees with
equity incentives primarily in the form of stock option grants. Generally, the
size of each option grant is set at a level which the Compensation Committee
deems appropriate to create a meaningful opportunity for stock ownership based
upon the individual's current position with the Company, but there is also taken
into account comparable awards made to individuals in similar positions in the
industry, as reflected in external surveys, the individual's potential for
future responsibility and promotion and the individual's performance in the
recent period. The Compensation Committee has also established general
guidelines for maintaining the unvested option holdings of each executive
officer at a targeted level based upon his or her position with the Company, and
option grants are periodically made to maintain the targeted levels. However,
the Committee does not strictly adhere to these guidelines, and the relative
weight given to each of the foregoing factors varies from individual to
individual as the Compensation Committee deems appropriate under the
circumstances.
 
          The grants are designed to align the interests of the executive
officer with those of the stockholders and provide each individual with a
significant incentive to manage the Company from the perspective of an owner
with an equity stake in the business. Each grant allows the officer to acquire
shares of Common Stock at a fixed price per share (the market price on the grant
date) over a specified period (up to ten years). Accordingly, the option will
provide a return to the executive officer only if he or she remains in the
Company's employ, and then only if the market price appreciates over the option
term.
 
     CEO Compensation.  In setting the compensation payable for the 1997 fiscal
year to the Company's President and Chief Executive Officer, Richard A. Miller,
the Committee reviewed a detailed performance evaluation compiled for Dr.
Miller. Such review considered Dr. Miller's qualifications, the level of
experience brought to his position and gained while in the position, Company
goals for which Dr. Miller had responsibility, specific accomplishments to date,
and the importance of Dr. Miller's individual achievement in meeting Company
goals and objectives set during the prior fiscal year. In addition, the
Compensation Committee surveyed the salary levels in effect for chief executive
officers at the peer group companies which
 
                                       20
<PAGE>   24
 
were taken into account for comparative compensation purposes for all of the
Company's other executive officers.
 
     In determining Dr. Miller's compensation level, the Committee sought to
establish a competitive rate of base salary, while at the same time tying a
significant percentage of his overall compensation package to individual and
Company performance, such as the attainment of certain milestones in the testing
of clinical products, the successful completion of two private placements and
stock price appreciation. Based on these factors, the Committee increased Dr.
Miller's base salary level to $247,500. The level of base salary set for Dr.
Miller was in the 42nd percentile of the surveyed salary for the peer group
companies.
 
     In fiscal 1997, the Company also granted Dr. Miller options to purchase
60,000 shares of the Company's Common Stock under the Plan, at an exercise price
of $15.75 per share. The grant was intended to provide Dr. Miller with a
meaningful incentive to continue in the Company's employ and contribute to the
Company's financial success, as reflected in the future appreciation in the
market price of the Company's Common Stock.
 
COMPLIANCE WITH INTERNAL REVENUE CODE SECTION 162(M)
 
     Section 162(m) of the Internal Revenue Code, enacted in 1993, generally
disallows a tax deduction to publicly held companies for compensation exceeding
$1 million paid to certain of the corporation's executive officers. The
limitation applies only to compensation which is not considered to be
performance-based. The non-performance based compensation to be paid to the
Company's executive officers for the 1997 fiscal year did not exceed the $1
million limit per officer, nor is it expected that the non-performance based
compensation to be paid to the Company's executive officers for fiscal 1998 will
exceed that limit. The Plan is structured so that any compensation deemed paid
to an executive officer in connection with the exercise of option grants made
under that plan with an exercise price equal to the fair market value of the
option shares on the grant date will qualify as performance-based compensation
which will not be subject to the $1 million limitation. Because it is very
unlikely that the cash compensation payable to any of the Company's executive
officers in the foreseeable future will approach the $1 million limit, the
Compensation Committee has decided at this time not to take any other action to
limit or restructure the elements of cash compensation payable to the Company's
executive officers. The Compensation Committee will reconsider this decision
should the individual compensation of any executive officer ever approach the $1
million level.
 
     The above report is submitted by the Compensation Committee of the
Company's Board of Directors.
 
                                Joseph S. Lacob
                              Patrick F. Latterell
                                Craig C. Taylor
 
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
     As of June 30, 1997, the Compensation Committee of the Board was comprised
of Messrs. Lacob, Latterell and Taylor.
 
     No executive officer of the Company served on the board of directors or
compensation committee of any entity which has one or more executive officers
serving as a member of the Company's Board or Compensation Committee.
 
                                       21
<PAGE>   25
 
PERFORMANCE GRAPH
 
     The graph depicted below shows the Company's stock price as an index
assuming $100 invested on October 23, 1995 (the date of the Company's initial
public offering) at the then current market price of $12.00 per share, along
with the composite prices of companies listed in the Nasdaq Pharmaceutical Index
and Nasdaq Total U.S. Stock Market Index. This information has been provided to
the Company by the Nasdaq Stock Market.
 
                     COMPARISON OF CUMULATIVE TOTAL RETURN*
          AMONG PHARMACYCLICS, INC., THE NASDAQ STOCK MARKET-US INDEX
                      AND THE NASDAQ PHARMACEUTICAL INDEX
 
<TABLE>
<CAPTION>
                                                              NASDAQ           NASDAQ STOCK
        MEASUREMENT PERIOD            PHARMACYCLICS,      PHARMACEUTICAL       MARKET (U.S.)
      (FISCAL YEAR COVERED)                INC.                INDEX               INDEX
<S>                                  <C>                 <C>                 <C>
10/23/95                                           100                 100                 100
06/30/96                                           147                 125                 115
06/30/97                                           129                 127                 140
</TABLE>
 
* $100 invested on 10/23/95 in stock or index -- including reinvestment of
  dividends. Fiscal Year ending June 30.
 
     Notwithstanding anything to the contrary set forth in any of the Company's
previous filings under the Securities Act of 1933, as amended, or the Securities
Exchange Act of 1934, as amended, which might incorporate future filings made by
the Company under those statutes, the preceding Compensation Committee Report on
Executive Compensation and the Company Stock Performance Graph will not be
incorporated by reference into any of those prior filings, nor will such report
or graph be incorporated by reference into any future filings made by the
Company under those statutes.
 
                                       22
<PAGE>   26
 
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
 
     The Company's Restated Certificate of Incorporation and Bylaws provide for
indemnification of directors, officers and other agents of the Company. Each of
the current directors, and certain officers and agents of the Company have
entered into separate indemnification agreements with the Company.
 
     The Company has entered into a Patent License Agreement with Dr. Stuart W.
Young, dated October 15, 1992, pursuant to which the Company has been granted an
exclusive royalty-bearing license to use and to manufacture and sell products
based on certain patent rights owned by Dr. Young related to certain zeolite and
zeolite-like substances. In consideration for entering into the Patent License
Agreement, the Company issued Dr. Young 16,667 shares of its Common Stock.
 
     In September 1994, the Company entered into a Note Secured by Stock Pledge
Agreement (the "First Note") with Dr. Stuart W. Young, an executive officer of
the Company, for the total principal amount of approximately $65,000. The First
Note bears interest at 5.86%, with interest payable annually and principal due
in full on August 31, 1997. In April 1995, the Company loaned Dr. Young
approximately an additional $30,000 under a similar Note Secured by Stock Pledge
Agreement (the "Second Note"). The Second Note bears interest at 7.19%, with
principal and interest due in full on February 28, 1998. The proceeds of such
Notes were to be used solely to pay federal and state tax liability incurred by
Dr. Young in connection with his acquisition of 50,000 shares of Common Stock
pursuant to his exercise of a non-statutory stock option grant under the
Company's 1992 Stock Option Plan. Dr. Young fully repaid both notes, plus all
accrued interest, during fiscal year 1997.
 
     The Company believes that all of the transactions set forth above were made
on terms no less favorable to the Company than could have been obtained from
unaffiliated third parties.
 
                        COMPLIANCE WITH SECTION 16(A) OF
                      THE SECURITIES EXCHANGE ACT OF 1934
 
     Section 16(a) of the Securities Exchange Act of 1934, as amended, requires
the Company's directors and executive officers, and persons who beneficially own
more than 10% of a registered class of the Company's equity securities, to file
with the United States Securities and Exchange Commission (the "SEC") initial
reports of beneficial ownership and reports of changes in beneficial ownership
of Common Stock and other equity securities of the Company. Officers, directors
and greater than 10% stockholders are required by SEC regulation to furnish the
Company with copies of all Section 16(a) reports they file.
 
     Based solely on its review of the copies of such forms furnished to the
Company and written representations that no other reports were required, the
Company believes that during the period from July 1, 1996 to June 30, 1997, all
officers, directors and beneficial owners of more than ten percent of the
outstanding Common Stock complied with all Section 16(a) requirements.
 
                       STOCK OWNERSHIP OF MANAGEMENT AND
                           CERTAIN BENEFICIAL OWNERS
 
     The following table sets forth certain information known to the Company
with respect to the beneficial ownership of the Common Stock as of September 30,
1997 by (i) all persons who are beneficial owners of five percent or more of the
Company's Common Stock, (ii) each director and nominee for director, (iii) the
Named Executive Officers in the Summary Compensation Table above and (iv) all
current directors and executive officers as a group. The number of shares
beneficially owned by each director or executive officer is determined under
rules of the SEC and the information is not necessarily indicative of beneficial
ownership for any other purpose. Shares of Common Stock subject to convertible
securities that are currently exercisable or convertible or which will become
exercisable or convertible within the next 60 days are deemed to be beneficially
owned by the person holding such convertible security for computing the
percentage ownership of such person, but are not treated as outstanding for
computing the percentage of any other person. Except as otherwise indicated, the
Company believes that the beneficial owners of the Common Stock listed below,
 
                                       23
<PAGE>   27
 
based upon such information furnished by such owners, have sole investment power
with respect to such shares, subject to community property laws where
applicable.
 
<TABLE>
<CAPTION>
                                                                                PERCENT OF
                                                               NUMBER OF       TOTAL SHARES
                        NAME AND ADDRESS                        SHARES       OUTSTANDING(1)(2)
    ---------------------------------------------------------  ---------     -----------------
    <S>                                                        <C>           <C>
    Asset Management Associates 1989, L.P.(3)................  1,194,628            11.8%
      2275 East Bayshore, Suite 150
      Palo Alto, CA 94303
    Kleiner Perkins Caufield & Byers V(4)....................    610,794             6.0
      2750 Sand Hill Road
      Menlo Park, CA 94025
    Richard A. Miller, M.D (5)...............................    601,077             5.9
    Quantum Partners LDC(6)..................................    600,000             5.9
      Kaya Flamboyan 9
      Willemstad
      Curacao, Netherlands Antilles
    Venrock Associates(7)....................................    352,554             3.4
      30 Rockefeller Plaza, Suite 5508
      New York, NY 10112
    Craig C. Taylor(8).......................................  1,194,628            11.8
    Joseph S. Lacob(9).......................................    610,794             6.0
    Patrick F. Latterell(10).................................    352,554             3.4
    Thomas D. Kiley(11)......................................    170,075             1.7
    Joseph C. Scodari(12)....................................     26,667               *
    Marc L. Steuer(13).......................................    176,150             1.7
    William C. Dow, Ph.D.(14)................................    138,469             1.4
    Cheryl B. Jaszewski(15)..................................     92,287               *
    All officers and directors as a group (9 persons)(16)....  3,972,183            39.2
</TABLE>
 
- ---------------
  *  Less than 1%.
 
 (1) Percentage of beneficial ownership is calculated assuming 10,140,287 shares
     of Common Stock were outstanding as of September 30, 1997. Beneficial
     ownership is determined in accordance with the rules of the Securities and
     Exchange Commission and generally includes voting or investment power with
     respect to securities. Shares of Common Stock subject to options or
     warrants currently exercisable or convertible, or exercisable or
     convertible within 60 days of September 30, 1996, are deemed outstanding
     for computing the percentage of the person holding such option or warrant
     but are not deemed outstanding for computing the percentage of any other
     person. Except as indicated in the footnotes to this table and pursuant to
     applicable community property laws, the persons named in the table have
     sole voting and investment power with respect to all shares of Common Stock
     beneficially owned.
 
 (2) This table is based upon information supplied to the Company by executive
     officers, directors and principal stockholders. The address of each officer
     and director identified in this table is that of the Company's executive
     offices, 995 East Arques Avenue, Sunnyvale, CA 94086. Unless otherwise
     indicated in the footnotes to this table and subject to applicable
     community property laws, each of the stockholders named in this table has
     sole voting and investment power with respect to the shares shown as
     beneficially owned by it or him.
 
 (3) Includes shares held by entities affiliated with Asset Management,
     including options exercisable for 20,000 shares held by Craig Taylor, a
     Director of the Company, who is a General Partner of AMC Partners 89, L.P.,
     the general partner of Asset Management. Mr. Taylor disclaims beneficial
     ownership of the shares held by Asset Management and its affiliated
     entities except to the extent of his individual share ownership and his
     pecuniary interest arising from his general partnership interest in AMC
     Partners 89, L.P. Also includes warrants exercisable for 20,038 shares held
     by Asset Management.
 
                                       24
<PAGE>   28
 
 (4) Includes shares held by persons and entities affiliated with Kleiner
     Perkins, including 67,655 shares held by Joseph Lacob, a Director of the
     Company, who is a General Partner of Kleiner Perkins. Mr. Lacob disclaims
     beneficial ownership of the shares held by Kleiner Perkins and its
     affiliated entities except to the extent of his individual share ownership
     and his pecuniary interest arising from his general partnership interest in
     Kleiner Perkins. Also includes options exercisable for 20,000 shares held
     by Mr. Lacob and warrants exercisable for 28,839 shares held by Kleiner
     Perkins.
 
 (5) Includes 13,334, 13,334, and 279,008 shares held in trust for Jordan Andrew
     Miller, Jared David Miller and the Miller-Homing Family Trust,
     respectively. Also, includes options exercisable for 306,667 shares within
     60 days of September 30, 1996.
 
 (6) Excludes 24,500 shares held by Quasar International Partners C.V. Soros
     Fund Management LLC may be deemed the beneficial owner of the shares held
     by each of Quantum Partners LDC and Quasar International Partners C.V.
 
 (7) Includes shares held by persons and entities affiliated with Venrock,
     including 49,715 shares held by Patrick Latterell, a Director of the
     Company, who is a General Partner of Venrock. Mr. Latterell disclaims
     beneficial ownership of the shares held by Venrock and its affiliated
     entities except to the extent of his individual share ownership and his
     pecuniary interest arising from his general partnership interest in
     Venrock. Also includes options exercisable for 20,000 shares held by Mr.
     Latterell.
 
 (8) Includes options exercisable for 20,000 shares. Also includes 1,174,628
     shares (including warrants for 20,038 shares) held by persons and entities
     affiliated with Asset Management, as to which shares Mr. Taylor disclaims
     beneficial ownership except as set forth in Note 3 above.
 
 (9) Includes options exercisable for 20,000 shares. Also includes 481,144
     (including warrants for 28,839 shares) held by persons and entities
     affiliated with Kleiner Perkins, as to which shares Mr. Lacob disclaims
     beneficial ownership except as set forth in Note 4 above.
 
(10) Includes 49,715 shares held in trust by the Patrick Latterell Living Trust
     and options exercisable for 20,000 shares. Also includes 282,839 shares
     held by persons and entities affiliated with Venrock, as to which shares
     Mr. Latterell disclaims beneficial ownership except as set forth in Note 7
     above.
 
(11) Includes 150,075 shares held in the Kiley Revocable Trust, Thomas D. Kiley,
     TEE, Nancy L. Kiley, TEE. Also, includes options exercisable for 20,000
     shares within 60 days of September 30, 1996.
 
(12) Represents options exercisable for 26,667 shares.
 
(13) Represents options exercisable for 213,334 shares.
 
(14) Includes options exercisable for 101,802 shares.
 
(15) Includes 334 shares held by Kristina Hulett. Also includes options
     exercisable for 54,600 shares.
 
(16) Includes options and warrants exercisable for 783,070 and 48,877 shares,
     respectively. Also includes 1,154,590 shares held by persons and entities
     affiliated with Asset Management, 481,144 shares held by persons and
     entitles affiliated with Kleiner Perkins and 292,321 shares held by persons
     and entities affiliated with Venrock. Certain directors may be deemed to be
     the beneficial owners of such shares, but disclaim such beneficial
     ownership, as discussed in Notes 3, 4, 7, 8, 9 and 10 above.
 
     To the Company's knowledge, each beneficial owner of more than ten percent
of the Company's capital stock filed all reports and reported all transactions
on a timely basis with the SEC, National Association of Securities Dealers, Inc.
and the Company.
 
                 DEADLINE FOR RECEIPT OF STOCKHOLDER PROPOSALS
 
     Under the present rules of the United States Securities and Exchange
Commission, the deadline for stockholders to submit proposals to be considered
for inclusion in the Company's Proxy Statement for the 1998 Annual Meeting of
Stockholders is expected to be July 20, 1998. Such proposals may be included in
next year's Proxy Statement if they comply with certain rules and regulations
promulgated by the United States Securities and Exchange Commission.
 
                                       25
<PAGE>   29
 
                                 ANNUAL REPORT
 
     A copy of the Annual Report of the Company for the fiscal year ended June
30, 1997 has been mailed concurrently with this Proxy Statement to all
stockholders entitled to notice of and to vote at the Annual Meeting. The Annual
Report is not incorporated into this Proxy Statement and is not considered
proxy-soliciting material.
 
                                   FORM 10-K
 
     The Company filed an Annual Report on Form 10-K (the "Form 10-K") with the
Securities and Exchange Commission. A copy of the Form 10-K has been mailed
concurrently with this Proxy Statement to all stockholders entitled to notice of
and to vote at the Annual Meeting. The Form 10-K is not incorporated into this
Proxy Statement and is not considered proxy-soliciting material. Stockholders
may obtain additional copies of the Form 10-K, without charge, by writing to
Cheryl B. Jaszewski, Pharmacyclics, Inc., 995 East Arques Avenue, Sunnyvale,
California 94086.
 
                                 OTHER MATTERS
 
     The Company knows of no other matters that will be presented for
consideration at the Annual Meeting. If any other matters properly come before
the Annual Meeting, it is the intention of the persons named in the enclosed
form of Proxy to vote the shares they represent as the Board may recommend.
Discretionary authority with respect to such other matters is granted by the
execution of the enclosed Proxy.
 
                                          THE BOARD OF DIRECTORS
 
Dated: November 14, 1997
 
                                       26


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