SYNTEX CORP
SC 14D1/A, 1994-06-21
PHARMACEUTICAL PREPARATIONS
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                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D. C. 20549

                                ---------------


                                AMENDMENT NO. 5
                                      TO
                                SCHEDULE 14D-1
                  Tender Offer Statement Pursuant to Section
                14(d)(1) of the Securities Exchange Act of 1934

                              Syntex Corporation
                           (Name of Subject Company)

                           Roche Capital Corporation
                                   (Bidder)

                    Common Stock, Par Value $1.00 Per Share
                        (Title of Class of Securities)

                                   87161610
                     (CUSIP Number of Class of Securities)

                               Dr. Felix Amrein
                             c/o Roche Holding Ltd
                             Grenzacherstrasse 124
                                 CH-4002 Basel
                                  Switzerland
                         Telephone: (41) (61) 688-1111
  (Name, Address and Telephone Number of Person Authorized to Receive Notices
                    and Communications on Behalf of Bidder)

                                ---------------

                                  Copies to:
                               Peter R. Douglas
                             Davis Polk & Wardwell
                             450 Lexington Avenue
                           New York, New York  10017
                          Telephone:  (212) 450-4000
                                  May 6, 1994

                                ---------------


     Date Tender Offer First Published, Sent or Given to Security Holders

==============================================================================



CUSIP No.  871 616 10


1   NAME OF REPORTING PERSON
    S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
        Roche Capital Corporation


2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)  [ ]
                                                          (b)  [ ]
3   SEC USE ONLY

4   SOURCE OF FUNDS*
        AF

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
    TO ITEMS 2 (e) OR 2 (f) [ ]

6   CITIZENSHIP OR PLACE OF ORGANIZATION
        Panama

7   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        0

8   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (7) EXCLUDES CERTAIN SHARES*  [ ]

9   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (7)
        N/A

10  TYPE OF REPORTING PERSON*
        CO


     This Amendment No. 5 amends and supplements the Tender Offer Statement
on Schedule 14D-1 (the ``Statement'') dated May 6, 1994 filed by Roche
Capital Corporation, a Panama corporation (the ``Bidder'') and a wholly
owned subsidiary of Sapac Corporation Limited, a non-resident Canadian
corporation (``Holding''), which, in turn, is a wholly owned subsidiary of
Roche Holding Ltd, a Switzerland corporation (``Parent''), as amended by
Amendments Nos. 1, 2, 3 and 4, relating to the Bidder's offer to purchase
all outstanding shares of Common Stock, $1.00 par value (the ``Shares'') of
Syntex Corporation (the ``Company''), at $24.00 per Share, net to the
seller in cash, upon the terms and subject to the conditions set forth in
the Offer to Purchase and the related Letter of Transmittal, copies of
which are attached as Exhibits (a)(1) and (a)(2) to the Statement (which
are herein referred to as the ``Offer'').  Capitalized terms not separately
defined herein shall have the meanings specified in the Statement.


Item 10.  Additional Information.

     (b)  On June 16, 1994, CFIUS informed the Bidder that CFIUS had
determined not to conduct an investigation in connection with the Offer.

     (c)  On June 20, 1994, the EC Commission informed the Bidder that the
EC Commission would not oppose the transactions contemplated by the Merger
Agreement and had declared the transactions compatible with the common
market.

                                 SIGNATURE

     After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and
correct.

                                        ROCHE CAPITAL CORPORATION


                                        By: /s/ DR. HENRI B. MEIER
                                           _______________________
                                                Dr. Henri B. Meier
                                                Vice-President


Dated: June 21, 1994


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