SYNTEX CORP
SC 14D1/A, 1994-05-27
PHARMACEUTICAL PREPARATIONS
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		      SECURITIES AND EXCHANGE COMMISSION
			    Washington, D. C. 20549

				---------------


				AMENDMENT NO. 3
				      TO
				SCHEDULE 14D-1
		  Tender Offer Statement Pursuant to Section
		14(d)(1) of the Securities Exchange Act of 1934

			      Syntex Corporation
			   (Name of Subject Company)

			   Roche Capital Corporation
				   (Bidder)

		    Common Stock, Par Value $1.00 Per Share
			(Title of Class of Securities)

				   87161610
		     (CUSIP Number of Class of Securities)

			       Dr. Felix Amrein
			     c/o Roche Holding Ltd
			     Grenzacherstrasse 124
				 CH-4002 Basel
				  Switzerland
			 Telephone: (41) (61) 688-1111
  (Name, Address and Telephone Number of Person Authorized to Receive Notices
		    and Communications on Behalf of Bidder)

				---------------

				  Copies to:
			       Peter R. Douglas
			     Davis Polk & Wardwell
			     450 Lexington Avenue
			   New York, New York  10017
			  Telephone:  (212) 450-4000
				  May 6, 1994

				---------------


     Date Tender Offer First Published, Sent or Given to Security Holders

==============================================================================



CUSIP No.  871 616 10


1   NAME OF REPORTING PERSON
    S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
	Roche Capital Corporation


2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
							  (a)  [ ]
							  (b)  [ ]
3   SEC USE ONLY

4   SOURCE OF FUNDS*
	AF

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
    TO ITEMS 2 (e) OR 2 (f) [ ]

6   CITIZENSHIP OR PLACE OF ORGANIZATION
	Panama

7   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	0

8   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (7) EXCLUDES CERTAIN SHARES*  [ ]

9   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (7)
	N/A

10  TYPE OF REPORTING PERSON*
	CO



     This Amendment No. 3 amends and supplements the Tender Offer Statement
on Schedule 14D-1 (the "Statement")  dated May 6, 1994 filed by Roche Capital
Corporation, a Panama corporation (the "Bidder") and a wholly owned subsidiary
of Sapac Corporation Limited, a non-resident Canadian corporation ("Holding"),
which, in turn, is a wholly owned subsidiary of Roche Holding Ltd, a
Switzerland corporation ("Parent"), as amended by Amendment Nos. 1 and 2,
relating to the Bidder's offer to purchase all outstanding shares of Common
Stock, $1.00 par value (the "Shares") of Syntex Corporation (the "Company"),
at $24.00 per Share, net to the seller in cash, upon the terms and subject to
the conditions set forth in the Offer to Purchase and the related Letter of
Transmittal, copies of which are attached as Exhibits (a)(1)  and (a)(2) to
the Statement (which are herein referred to as the "Offer"). Capitalized terms
not separately defined herein shall have the meanings specified in the
Statement.

       THE FOLLOWING INFORMATION SUPPLEMENTS THE OFFER TO PURCHASE

       ITEM 5. PURPOSE OF THE TENDER OFFER AND PLANS AND PROPOSALS
       OF THE BIDDER.

       In the event that more than 299 holders of Shares make
       otherwise valid Stock Elections, but the Purchaser and the
       Special Committee of the Company are unable jointly to
       agree, in their discretion, the method for selecting holders
       who will be entitled to receive LCPS pursuant to otherwise
       valid Stock Elections (which method may consist of a
       lottery, selection by lot or according to the aggregate
       number of Shares as to which a holder makes a valid Stock
       Election, or any other method), the Merger Agreement
       provides that the Purchaser may, in its sole discretion,
       agree with any stockholder of the Company to exchange such
       stockholder's Shares for a security having terms no more
       favorable to such stockholder than the terms of the LCPS (an
       "Alternative Exchange"), so long as all such Alternative
       Exchanges, if any, are effected on equivalent terms.
       Purchaser will not, however, be required to agree to make an
       Alternative Exchange with any stockholder of the Company and
       may, in its sole discretion, determine to effect an
       Alternative Exchange with one or more, but fewer than all,
       stockholders who may have made a Stock Election or otherwise
       desire to effect an Alternative Exchange.  Any determination
       by the Purchaser to effect or not effect an Alternative
       Exchange with any stockholder will be made in the sole
       discretion of the Purchaser.  There can be no assurance that
       any Alternative Exchanges will be effected, nor any
       assurance that if more than one such Alternative Exchange is
       effected, that all such Alternative Exchanges will be
       effected in the same manner, at the same time or with the
       same effects on stockholders with whom the Purchaser effects
       Alternative Exchanges.  The time and manner of any
       Alternative Exchange will be determined by the Purchaser in
       its sole discretion, subject only to any restrictions in the
       Merger Agreement.

       ITEM 10.  ADDITIONAL INFORMATION.

	    (c)  EC Merger Regulation.  Purchaser filed the
       required notice pursuant to the EC Merger Regulation with
       the EC Commission on May 16, 1994.  The EC Commission
       confirmed on May 26, 1994 that the notified concentration
       has a "community dimension" and that the EC Commission has
       jurisdiction to review the transaction.  The EC Commission
       has invited, as is customary, third parties to comment on
       the notified transaction within ten days.  Although the EC
       Merger Regulation does not prohibit the Purchaser from
       acquiring the Shares prior to the end of the "suspension"
       period (currently expected to end on June 13, 1994), the EC
       Merger Regulation would not allow the Purchaser to vote
       Shares prior to the end of the "suspension" period.  In
       addition, the EC Commission may determine to extend the
       "suspension" period applicable to the Offer. The EC
       Commission may also, on or before June 20, 1994, decide to
       initiate proceedings with respect to the Offer.

	    See Sections 14 and 15 of the Offer to Purchase for
       information concerning conditions to the Offer and the
       Purchaser's rights to extend or amend the Offer and to delay
       acceptance for payment or payment for Shares.

	    (f)  Purchaser has been informed that the Company, on
       May 27, 1994, issued the following press release.

		 "Syntex Corporation (NYSE:  SYN) today reported operating
       income of $23.6 million in the fiscal 1994 third quarter which ended
       April 30, an increase of 26 percent compared to $18 million in the
       fiscal third quarter, after a $140 million restructuring charge.
       Net income in the third fiscal quarter was $22.4 million in 1994
       versus $40.8 million in 1993.  Earnings per share in the fiscal 1994
       third quarter decreased by 44 percent to $.10 per share compared
       with earnings per share of $.18 in the fiscal 1993 third quarter.
       The fiscal 1993 third quarter restructuring charge reduced net
       earnings by $.48 per share.  Sales in the fiscal 1994 third quarter
       decreased 31 percent to $402.1 million, compared with sales of
       $584.3 million in the third quarter a year ago.  The fiscal 1994
       third quarter is the first full quarter in which non-Syntex generic
       competition for Naprosyn [Registered Trademark] (naproxen) and
       Anaprox [Registered Trademark] (naproxen sodium) occurred following
       the December 1993 expiration of the U.S. patent for these products.

		 As previously announced, Syntex and Roche Holding Ltd,
       Basel, have entered into a definitive agreement for the acquisition
       of Syntex by a subsidiary of Roche.  A cash tender offer by Roche to
       purchase all of Syntex's outstanding stock at $24 per share is
       currently underway and is scheduled to expire June 6 unless extended
       by Roche.  The Syntex Board of Directors has unanimously recommended
       that stockholders tender their shares in the offer.  The tender
       offer is subject to certain conditions, including that at least a
       majority of Syntex shares are tendered and certain regulatory
       approvals are obtained.



				    2



	 "FISCAL 1994 THIRD QUARTER AND NINE MONTHS RESULTS
	 ($ in millions, except per-share data)

				     PERCENT                          PERCENT
		  THIRD QUARTER      CHANGE      NINE MONTHS          CHANGE
	       -------------------   ------   ------------------      ------
	       FY 1994     FY 1993              FY 1994     FY 1993
	       -------     -------              -------     -------

Net Sales      $402.1       $584.3    (31)     $1,403.5    $1,582.0    (11)

Operating       $23.6       $158.8    (85)       $253.4      $368.0    (31)
 Income Before
 Restructuring
 Charge

Restructuring    --         $140.0     --          --        $320.0     --
 Charge

Operating       $23.6        $18.8     26        $253.4       $48.0    100+
 Income After
 Restructuring
 Charge

Net Income      $22.4        $40.8    (45)       $244.5      $153.8     59

Earnings Per     $.10         $.18    (44)        $1.10        $.69     59
 Share



       "'The decline in sales and earnings in the fiscal
       1994 third quarter compared with the third quarter a year
       ago was primarily due to the expiration of the U.S. patent
       for Naprosyn and Anaprox and the shift in sales from those
       branded products to lower-priced generic naproxen and
       naproxen sodium products,' said Paul E. Freiman, chairman
       and chief executive officer of Syntex Corporation.

		 "The gross margin declined to 71.5 percent in the
       fiscal 1994 third quarter, due to significantly reduced
       sales of the higher-margin Naprosyn and Anaprox branded
       products in the U.S. and to excess production capacity.  In
       the fiscal 1993 third quarter, the gross margin was 77.3
       percent.


				    3



	 "WORLDWIDE HUMAN PHARMACEUTICAL SALES
	 ($ in millions)


				     PERCENT                           PERCENT
		  THIRD QUARTER      CHANGE       NINE MONTHS          CHANGE
	       -------------------   ------    ------------------      ------
	       FY 1994     FY 1993             FY 1994     FY 1993
	       -------     -------             -------     -------


U.S. Sales     $187.5      $371.0    (49)       $779.1      $947.1      (18)

Non-U.S.        144.1       141.2     2          417.4       416.4       --
	       ------      ------             --------    --------
 Sales

  TOTAL        $331.6      $512.2    (35)     $1,196.5    $1,363.5      (12)
	       ======      ======             ========    ========


	 NAPROXEN/NAPROXEN SODIUM SALES
	 ($ in millions)


				     PERCENT                         PERCENT
		  THIRD QUARTER      CHANGE       NINE MONTHS        CHANGE
	       ------------------    ------    ------------------    ------
	       FY 1994     FY 1993             FY 1994     FY 1993
	       -------     -------             -------     -------


U.S. Sales     $36.1       $200.0    (82)      $339.8      $503.3      (32)

Non-U.S.        58.3         61.6     (5)       175.8       188.3       (7)
 Sales         -----       ------              ------      ------

TOTAL          $94.4       $261.6    (64)      $515.6      $691.5      (25)
	       =====       ======              ======      ======


		 "Worldwide sales of Toradol [Registered Trademark]
       (ketorolac tromethamine) in the fiscal 1994 third quarter decreased
       15 percent to $81.1 million from $95.0 million in the prior-year
       third quarter.


		 "As previously announced, Syntex and The Proctor & Gamble
       Company will begin marketing ALEVE [Registered Trademark] , a new,
       over-the-counter pain reliever with naproxen sodium as its key
       ingredient, in the United States in the fiscal 1994 fourth quarter.


		 "Selling, general and administrative (SG&A)
       expenses in the fiscal 1994 third quarter decreased 15
       percent to $161.5 million from the third quarter a year ago.
       Mr. Freiman noted that Syntex has significantly reduced
       quarterly SG&A expenses since it initiated restructuring
       activities in November 1992.


				    4



		 "Spending for research and development in the
       third quarter of fiscal 1994 was $102.4 million, a 1 percent
       decrease from the third quarter a year ago.

		 "Mr.  Freiman said the company expects to submit New Drug
       Applications to the U.S.  Food and Drug Administration for oral
       Cytovene [Registered Trademark] (ganciclovir sodium) for the
       maintenance treatment of cytomegalovirus retinitis in the first half
       of calendar 1994 and for mycophenolate mofetil for the prevention of
       acute kidney transplant rejection in the second half of calendar
       1994.  The results of preliminary analyses of data from three
       recently-completed clinical studies to determine the effectiveness
       of mycophenolate mofetil as adjunctive therapy for the prevention of
       acute kidney transplant rejection appear to be positive.



	    "The provision for income taxes in the fiscal 1994 third
       quarter reflects an effective tax rate of 6 percent.  The effective
       tax rate in the fiscal 1993 third quarter was 4 percent, excluding a
       $34.1 million benefit for the restructuring charge.

	    "Consolidated statements of income follow.


				    5







       "SYNTEX CORPORATION AND SUBSIDIARY COMPANIES
       Consolidated Statements of Income
       (In millions, except per-share amounts)


					  PERCENT                      PERCENT
		       THIRD QUARTER      CHANGE      NINE MONTHS      CHANGE
		    ------------------    ------   ------------------  ------
		    FY 1994     FY 1993            FY 1994    FY 1993
		    -------     -------            -------    -------


Net Sales            $ 402.1     $584.3    (31)    $1,403.5   $1,582.0  (11)
Costs and expenses:
  Costs of goods
    sold               114.6      132.5    (14)       343.8      332.8    3
  Selling, general &
    administrative     161.5      189.9    (15)       507.8      580.6  (13)
  Research &
   development         102.4      103.1     (1)       298.5      300.6   (1)
  Restructuring
      charge            --        140.0     --           --      320.0   --
		     -------     ------            --------   --------
      Total            378.5      565.5    (33)     1,150.1    1,534.0  (25)

Operating income        23.6       18.8     26        253.4       48.0  100+
		     -------     ------            --------   --------
Nonoperating income
 (expense):
   Interest income       9.2        9.3     (1)        26.6       30.8  (14)
   Interest expense     (7.2)      (6.9)     4        (20.4)     (20.6)  (1)
   Other--net           (1.8)      (8.4)   (79)        (9.5)     (64.4) (85)
		     -------     ------            --------   --------

      Total              0.2       (6.0)   100+        (3.3)     (54.2) (94)
		     -------     ------            --------   --------

Income (loss) before
 taxes on income &
 cumulative effect
 of accounting
 changes                23.8       12.8     86        250.1       (6.2) 100+
Provision (benefit)
 for taxes on income     1.4      (28.0)   100+         5.6     (160.9) 100+
		     -------     ------            --------   --------
Income before
 cumulative effect
 of accounting
 changes                22.4       40.8    (45)       244.5      154.7   58
Cumulative effect of
 accounting changes,
 net of tax               --         --     --           --        (.9)  --
		     -------     ------            --------   --------

   Net income         $ 22.4      $40.8    (45)      $244.5     $153.8   59
		      ======      =====              ======     ======

Shares used in       $221.1       220.9               221.0      222.9
 computing earnings  ======       =====               =====      =====
 per common share

Earnings per common  $.10          $.18    (44)       $1.10       $.69   59"
  share              ====          ====               =====       ====



				    6




				   SIGNATURE


     After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and
correct.


					ROCHE CAPITAL CORPORATION



				    By: DR. HENRI B. MEIER
				       -------------------------
					Dr. Henri B. Meier
					Vice-President


Dated: May 27, 1994


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