COLLAGENEX PHARMACEUTICALS INC
SC 13G/A, 2000-02-14
PHARMACEUTICAL PREPARATIONS
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                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                 SCHEDULE 13G

                   Under the Securities Exchange Act of 1934

                               (Amendment No.3)*


                       COLLAGENEX PHARMACEUTICALS, INC.
                               (Name of Issuer)

                                 Common Stock
                        (Title of Class of Securities)

                                  19419B-10-0
                                (CUSIP Number)

                        December 31, 1999 (Annual Filing)
            (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

     [_] Rule 13d-1(b)
     [_] Rule 13d-1(c)
      X  Rule 13d-1(d)

*The remainder of this cover page should be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information with would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
<PAGE>
CUSIP No. 19419B-10-0                 13G             Page  2    of  8
                                                          -----    -----

1.   NAME OF REPORTING PERSON
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     Columbine Venture Fund II, L.P.

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

      [a]  [_]
      [b]  [_]

3.   SEC USE ONLY

4.   CITIZENSHIP OF PLACE OF ORGANIZATION
     Delaware, USA

NUMBER OF                     5.   SOLE VOTING POWER
SHARES BENE-                       654,082
FICIALLY OWNED                6.   SHARED VOTING POWER
BY EACH REPORTING             7.   SOLE DISPOSITIVE POWER
PERSON WITH                        654,082
                              8.   SHARED DISPOSITIVE POWER

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          654,082

10.  CHECK BOX OF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
     (See instructions)

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11
     7.6%

12.  TYPE OF REPORTING PERSON (See instructions)
     PN



<PAGE>
CUSIP No. 19419B-10-0                 13G             Page  3    of  8
                                                          -----    -----

1.   NAME OF REPORTING PERSON
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     Columbine Venture Management II

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     [a]  [_]
     [b]  [_]

3.   SEC USE ONLY

4.   CITIZENSHIP OF PLACE OF ORGANIZATION
     Delaware, USA

NUMBER OF                     5.   SOLE VOTING POWER
SHARES BENE-                       728,446
FICIALLY OWNED                6.   SHARED VOTING POWER
BY EACH REPORTING             7.   SOLE DISPOSITIVE POWER
PERSON WITH                        728,446
                              8.   SHARED DISPOSITIVE POWER

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          728,446

10.  CHECK BOX OF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
     (See instructions)

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11
     8.5%

12.  TYPE OF REPORTING PERSON (See instructions)
     PN



<PAGE>
CUSIP No. 19419B-10-0                 13G             Page  4    of  8
                                                          -----    -----

1.   NAME OF REPORTING PERSON
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     Sherman J. Muller

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

          [a]  [_]
          [b]  [_]

3.   SEC USE ONLY

4.   CITIZENSHIP OF PLACE OF ORGANIZATION
     USA

NUMBER OF                     5.   SOLE VOTING POWER
SHARES BENE-                  6.   SHARED VOTING POWER
FICIALLY OWNED                728,446
BY EACH REPORTING             7.   SOLE DISPOSITIVE POWER
PERSON WITH                   8.   SHARED DISPOSITIVE POWER
                              728,446

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          728,446

10.  CHECK BOX OF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
     (See instructions)

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11
     8.5%

12.  TYPE OF REPORTING PERSON (See instructions)
     IN



<PAGE>
CUSIP No. 19419B-10-0                 13G             Page  5    of  8
                                                          -----    -----

1.   NAME OF REPORTING PERSON
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     Terence E. Winters

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     [a]  [_]
     [b]  [_]

3.   SEC USE ONLY

4.   CITIZENSHIP OF PLACE OF ORGANIZATION
     USA

NUMBER OF                     5.   SOLE VOTING POWER
SHARES BENE-                  6.   SHARED VOTING POWER
FICIALLY OWNED                728,446
BY EACH REPORTING             7.   SOLE DISPOSITIVE POWER
PERSON WITH                   8.   SHARED DISPOSITIVE POWER
                              728,446

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          728,446

10.  CHECK BOX OF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
     (See instructions)

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11
     8.5%

12.  TYPE OF REPORTING PERSON (See instructions)
     IN



<PAGE>
CUSIP No. 19419B-10-0                                 Page  6    of  8
                                                          -----    -----

Item No. 1:
- - ----------

     CollaGenex Pharmaceuticals, Inc.
     301 S. State Street
     Newtown, Pennsylvania 18940

Item No. 2:
- - ----------

     (a)   Columbine Venture Fund II, L.P.
     (b)   5460 S. Quebec Street, Suite 270
           Englewood, Colorado 80111
     (c)   Delaware, USA
     (d)   Common Stock
     (e)   CUSIP No. 19419B-10-0

     (a)   Columbine Venture Management II
     (b)   5460 S. Quebec Street, Suite 270
           Englewood, Colorado 80111
     (c)   Delaware, USA
     (d)   Common Stock
     (e)   CUSIP No. 19419B-10-0

     (a)   Sherman J. Muller
     (b)   5460 S. Quebec Street, Suite 270
           Englewood, Colorado 80111
     (c)   USA
     (d)   Common Stock
     (e)   CUSIP No. 19419B-10-0

     (a)   Terence E. Winters
     (b)   10040 East Happy Valley Road, No. 366
           Scottsdale, Arizona 85255
     (c)   USA
     (d)   Common Stock
     (e)   CUSIP No. 19419B-10-0



<PAGE>
CUSIP No. 19419B-10-0                                 Page  7    of  8
                                                          -----    -----

Item No. 3:
- - ----------

     Not applicable.


Item No. 4:
- - ----------

     Reporting Persons incorporate by reference the information on ownership
contained under numbers 5, 6, 7, 8, 9, 10 and 11 of the cover sheets.  The
numbers include 713,446 shares of Common Stock and options to purchase 15,000
shares of Common Stock that are now exercisable. Title to 654,082 shares of
Common Stock is held by Columbine Venture Fund II, L.P. ("Columbine") which
does not hold an interest in the options or in 59,364 shares of Common Stock,
title to which is held by Columbine Venture Management II ("Management").
Management is the sole general partner of Columbine and is a reporting person
with respect to the shares held by Columbine by virtue of its voting power
and dispositive power over the shares held by Columbine.  The individuals are
general partners in Columbine Venture Management II, and each is a reporting
person with respect to the shares held by Columbine and Management by virtue
of his shared voting and dispositive power over the shares held by Columbine
in which he is a general partner of the general partner and Management in
which he is a general partner.  Each reporting person, other than Columbine,
disclaims his or its interest in the Common Stock, except to the extent of
his or its proportionate interest as a partner.  The reporting persons other
than Columbine also have an interest in options exercisable for an additional
10,000 shares of Common Stock, which are not exercisable within 60 days.
These options will vest and become exercisable as follows:  (i) options for
4,000 of the shares will vest in increments of 2,000 shares each on June 20,
2000 and June 20, 2001, and (ii) options for 6,000 of the shares will vest in
increments of 3,000 shares each on November 22, 2000 and November 22, 2001.
If not previously exercised, options for 10,000 shares will expire on June 20,
2006 and the remaining options will expire on November 22, 2006.  Therefore,
the number of shares held (and corresponding change in the percentage held)
by each reporting person other than Columbine will increase for the end of
2000 and the end of 2001 by 5,000 shares to account for options which will
have become exercisable by the end of each such year.

Item No. 5:
- - ----------

Not Applicable.


Item No. 6:
- - ----------

     No person, other than the reporting person, has a right to receive or the
power to direct the receipt of dividends from, or the proceeds from the sale of,
the securities.

<PAGE>
CUSIP No. 19419B-10-0                                 Page  8    of  8
                                                          -----    -----


Item No. 7:
- - ----------

     Not applicable.


Item No. 8:
- - ----------

     Not applicable.

Item No. 9:
- - ----------

     Not applicable.

Item No. 10:
- - -----------

     Not applicable.



                                   SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                       February 14, 2000



                                       /s/ JAMES A. JACOBSON
                                       _________________________________________
                                       James A. Jacobson, as agent and
                                       attorney-in-fact for each reporting
                                       person pursuant to powers of attorney
                                       attached hereto


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