COLLAGENEX PHARMACEUTICALS INC
SC 13G/A, 2000-02-14
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                                  ___________

                                  SCHEDULE 13G
                                 (Rule 13d-102)

            INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2
                   UNDER THE SECURITIES EXCHANGE ACT OF 1934
                              (Amendment No. 2)/1/

                        CollaGenex Pharmaceuticals, Inc.
                        --------------------------------
                                (Name of Issuer)

                    Common Stock, $0.01 Par Value Per Share
                    ---------------------------------------
                         (Title of Class of Securities)

                                   19419B100
                            -----------------------
                                (CUSIP Number)

                                  ___________



_______________________

/1/ The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



                              Page 1 of 12 Pages
<PAGE>

  CUSIP NO.  19419B100                13G                   Page 2 of 12 Pages

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS: Marquette Venture Partners II, L.P.
 1

      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: 36-3820302
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [_]

                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4

      Delaware
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                          None
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY             891,896
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING
                          None
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          891,896
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      891,896
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10
                                                                    [_]

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11

      10.4%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

      PN
- ------------------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

  CUSIP NO.  19419B100               13G                    Page 3 of 12 Pages

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS: MVP II Affiliates Fund, L.P.
 1


      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: 36-3871877
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]

                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4

      Delaware
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                          None
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY             30
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING
                          None
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          30
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      30
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10
                                                                    [_]

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11

      0.00000035%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

      PN
- ------------------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

  CUSIP NO.  19419B100               13G                    Page 4 of 12 Pages

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS: Marquette General II, L.P.
 1


      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS: 36-3820303
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [_]

                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4

      Delaware
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                          None
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY             891,926
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING
                          None
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          891,926
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      891,926
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10
                                                                    [_]

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11

      10.4%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

      PN
- ------------------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

  CUSIP NO.  19419B100               13G                    Page 5 of 12 Pages

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS: Redfish Partners, L.P. (formerly known as JED
                                  Limited Partnership)
 1


      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS: 36-3760173
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [_]

                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4

      Delaware
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                          None
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY             891,926
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING
                          None
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          891,926
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      891,926
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10
                                                                    [_]

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11

      10.4%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

      PN
- ------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

  CUSIP NO.  19419B100                13G                   Page 6 of 12 Pages

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS: Bluefish Partners, L.P. (formerly known as LDR
      Limited Partnership)
 1

      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: 36-3760176
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [_]

                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4

      Delaware
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                          None
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY             891,926
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING
                          None
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          891,926
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      891,896
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10
                                                                    [_]

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11

      10.4%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

      PN
- ------------------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>


  CUSIP NO.  19419B100               13G                    Page 7 of 12 Pages

- ------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS: James E. Daverman
 1


      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: ###-##-####
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]

                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4

      United States of America
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                          20,000
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY             891,926
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING
                          20,000
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          891,926
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      911,926
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10
                                                                    [_]

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11

      10.6%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

      IN
- ------------------------------------------------------------------------------

                     * SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>


  CUSIP NO.  19419B100               13G                    Page 8 of 12 Pages

- ------------------------------------------------------------------------------
      NAME OF REPORTING PERSON: Lloyd D. Ruth
 1


      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: ###-##-####
- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
 2                                                              (a) [_]

                                                                (b) [_]
- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4

      United States of America
- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                          15,000
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY             891,926
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING
                          15,000
      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          891,926
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      906,926
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
10
                                                                    [_]

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11

      10.6%
- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON*
12

      IN
- ------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

Item 1(a) Name of Issuer:
          --------------

          CollaGenex Pharmaceuticals, Inc. ("CollaGenex")

Item 1(b) Address of Issuer's Principal Executive Offices:
          -----------------------------------------------

          301 S. State Street
          Newtown, PA 18940

Item 2(a) Name of Person Filing:
          ---------------------

          This Schedule 13G is being jointly filed by each of the following
          persons pursuant to Rule 13d-(1)(f) promulgated by the Securities and
          Exchange Commission pursuant to Section 13 of the Securities Exchange
          Act of 1934, as amended (the "Act"): (i) Marquette Venture Partners
          II, L.P. ("MVP II"), a Delaware limited partnership, by virtue of its
          direct beneficial ownership of 891,896 shares of common stock, par
          value $0.01 per share (the "Common Stock"), of CollaGenex; (ii) MVP II
          Affiliates Fund, L.P. ("MVP II Affiliates"), a Delaware limited
          partnership, by virtue of its direct beneficial ownership of 30 shares
          of Common Stock; (iii) Marquette General II, L.P. ("MG II"), a
          Delaware limited partnership, as the sole general partner of MVP II
          and MVP II Affiliates; (iv) Redfish Partners, L.P. ("Redfish"), a
          Delaware limited partnership, as a general partner of MG II; (v)
          Bluefish Partners, L.P. ("Bluefish"), a Delaware limited partnership,
          as a general partner of MG II; (vi) James E. Daverman ("Mr.
          Daverman"), as an individual and an affiliate of Redfish; and (vii)
          Lloyd D. Ruth ("Mr. Ruth"), as an individual and an affiliate of
          Bluefish. MVP II, MVP II Affiliates, MG II, Redfish, Bluefish, Mr.
          Daverman and Mr. Ruth are hereinafter collectively referred to as the
          "Reporting Persons."

          The Reporting Persons have entered into a Joint Filing Agreement,
          dated February 13, 1997, a copy of which was previously filed with
          this Schedule 13G pursuant to which the Reporting Persons have agreed
          to file this statement jointly in accordance with the provisions of
          Rule 13d-1(f)(1) under the Act.

Item 2(b) Address of Principal Business Office or, if none,
          Residence:
          _________________________________________________

          The address of the principal business office of each of the Reporting
          Persons is:

          Corporate 500 Centre
          520 Lake Cook Road, Suite 450
          Deerfield, Illinois 60015


                              Page 9 of 12 Pages
<PAGE>

Item 2(c) Citizenship
          -----------

          MVP II, MVP II Affiliates, MG II, Redfish and Bluefish are limited
          partnerships organized under the laws of Delaware.
          Mr. Daverman and Mr. Ruth are United States citizens.

Item 2(d) Title of Class of Securities:
          ----------------------------

          Common Stock, $0.01 par value per share.

Item 2(e) CUSIP No.:
          ---------

          19419B100

Item 3    If this statement is filed pursuant to Rules 13d-1(b)
          or 13d-2(b), check whether the persons filing is a:
          -----------------------------------------------------

          The persons filing are not described in any category listed under this
          item.

Item 4    Ownership
          ---------

          MG II is the sole general partner of both MVP II and MVP II
          Affiliates; Redfish and Bluefish are the general partners of MG II;
          Mr. Daverman is an affiliate of Redfish; and Mr. Ruth is an affiliate
          of Bluefish. As a result of such relationships, MG II, Redfish and
          Bluefish and both Messrs. Daverman and Ruth may be deemed to share
          voting and dispositive power with respect to the shares held by MVP II
          and MVP II Affiliates. The cover pages are incorporated herein by
          reference.

          Each Reporting Person expressly disclaims beneficial ownership of any
          shares of Common Stock beneficially owned by each other Reporting
          Person.

Item 5    Ownership of Five Percent or Less of a Class:
          --------------------------------------------

          If this statement is being filed to report the fact that as of the
          date hereof the reporting person has ceased to be the beneficial owner
          of more than five percent of the class of securities, check the
          following [ ].

Item 6    Ownership of More Than Five Percent on Behalf of
          Another Person:
          ------------------------------------------------

          No other person has the right to receive or the power to direct the
          receipt of dividends from, or other proceeds from the sale, of the
          shares.


                              Page 10 of 12 Pages
<PAGE>

Item 7    Identification and Classification of the Subsidiary Which
          Acquired the Security Being Reported on By the
          Parent Holding Company:
          ---------------------------------------------------------

          Not applicable.

Item 8    Identification and Classification of Members of the
          Group:
          ---------------------------------------------------

          Not applicable.

Item 9    Notice of Dissolution of Group:
          ------------------------------

          Not applicable.

Item 10   Certification:
          -------------

          Not applicable.


                              Page 11 of 12 Pages
<PAGE>

                                   SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date:  February 14, 2000

                                   MARQUETTE VENTURE PARTNERS II, L.P.

                                   MVP II AFFILIATES FUND, L.P.

                                   MARQUETTE GENERAL II, L.P.

                                   BLUEFISH PARTNERS, L.P.


                                   By:   /s/ Lloyd D. Ruth
                                       -------------------
                                          Lloyd D. Ruth
                                          as authorized signatory


                                   REDFISH PARTNERS, L.P.


                                   By:   /s/  James E. Daverman
                                       ------------------------
                                           James E. Daverman
                                           as authorized signatory



                                         /s/  James E. Daverman
                                       ------------------------
                                         JAMES E. DAVERMAN


                                        /s/ Lloyd D. Ruth
                                      -------------------
                                         LLOYD D. RUTH


                              Page 12 of 12 Pages


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