PATIENT INFOSYSTEMS INC
DEF 14A, 1997-05-16
MISC HEALTH & ALLIED SERVICES, NEC
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                            PATIENT INFOSYSTEMS, INC.
                                46 Prince Street
                            Rochester, New York 14607

May 16, 1997

Dear Stockholder:

     You are cordially  invited to attend the Patient  Infosystems,  Inc. Annual
Meeting of Stockholders to be held at 10:00 a.m. Eastern Daylight Time, Tuesday,
June 17,  1997 in the Bausch & Lomb  Parlor at the  Memorial  Art  Gallery,  500
University Avenue, Rochester, New York 14607.

     The matters  proposed for  consideration at the meeting are the election of
five directors,  the ratification of the appointment of Deloitte & Touche LLP as
the Company's  auditors,  and to transact  other business as may come before the
meeting or any adjournment thereof. The accompanying Notice of Annual Meeting of
Stockholders  and Proxy Statement  discuss these matters in further  detail.  We
urge you to review this information carefully.

     You will  have an  opportunity  at the  meeting  to  discuss  each  item of
business  described in the Notice of Annual  Meeting of  Stockholders  and Proxy
Statement and to ask questions about the Company and its operations.

     It is  important  that your shares be  represented  and voted at the Annual
Meeting.  Whether or not you plan to attend, please sign and promptly return the
enclosed proxy card,  using the envelope  provided.  If you do attend the Annual
Meeting, you may withdraw your proxy and vote your shares in person.

                                     Sincerely,

                                     DONALD A. CARLBERG
                                     President and Chief Executive Officer

<PAGE>

                            PATIENT INFOSYSTEMS, INC.
                                46 Prince Street
                            Rochester, New York 14607

                                   ----------
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JUNE 17, 1997
                                   ----------

     The Annual Meeting of  Stockholders  of Patient  Infosystems,  Inc. will be
held on Tuesday, June 17, 1997 at 10:00 a.m. Eastern Daylight Time in the Bausch
& Lomb Parlor at the Memorial Art Gallery, 500 University Avenue, Rochester, New
York 14607 for the following purposes:

     1.   To elect five  directors to hold office until the next Annual  Meeting
          of  Stockholders or until their  respective  successors have been duly
          elected and qualified;

     2.   To ratify the appointment of Deloitte & Touche LLP as auditors; and

     3.   To  transact  such other  business  as may  properly  come  before the
          meeting or any adjournment thereof.

     The Board of Directors  has fixed the close of business on  Wednesday,  May
14, 1997 as the record date for the  determination  of stockholders  entitled to
notice of and to vote at the Annual Meeting of Stockholders.

     The Company  requests that all  stockholders,  whether or not you expect to
attend  this  meeting,  sign the  enclosed  proxy and return it as  promptly  as
possible in the accompanying postage paid envelope. You may revoke your proxy at
any time  before it is voted.  If you are present at the  meeting,  you may vote
your shares in person and the proxy will not be used.

     You are  respectfully  urged to read the Proxy Statement  contained in this
booklet for further information  concerning  individuals nominated as directors,
the appointment of Deloitte & Touche LLP as auditors and the use of the proxy.

     A copy of the Company's  Annual Report to Stockholders  for the fiscal year
ended December 31, 1996 accompanies this Proxy Statement.

                                       By Order of the Board of Directors,

                                           GREGORY D. BROWN
                                           Secretary

May 16, 1997

                   IMPORTANT -- PLEASE MAIL YOUR SIGNED PROXY
                        PROMPTLY IN THE ENCLOSED ENVELOPE

<PAGE>

                            PATIENT INFOSYSTEMS, INC.
                                46 Prince Street
                            Rochester, New York 14607

                                   ----------
                                 PROXY STATEMENT
                                   ----------

         For the Annual Meeting of Stockholders to be held June 17, 1997

     This Proxy  Statement is furnished in connection  with the  solicitation of
proxies  to  be  voted  at  the  Annual  Meeting  of   Stockholders  of  Patient
Infosystems,  Inc.  (the  "Company"  or  "Patient  Infosystems"),  to be held on
Tuesday,  June 17, 1997, and at any postponements or adjournments  thereof,  for
the  purposes  set  forth  in the  accompanying  Notice  of  Annual  Meeting  of
Stockholders.   This  Proxy   Statement  and  the  proxy  are  being  mailed  to
stockholders on or about May 16, 1997.

     The  enclosed  proxy is  solicited by the Board of Directors of the Company
and will be voted at the Annual  Meeting and any  adjournments  thereof.  Shares
represented by a properly  executed proxy in the accompanying form will be voted
at the Annual  Meeting in  accordance  with any  instructions  specified  by the
stockholder.  If no instructions  are given,  the  stockholder's  shares will be
voted in accordance with the  recommendations of the Board of Directors FOR each
of the proposals  presented in this Proxy Statement.  Those  recommendations are
described later in this Proxy Statement.

     The proxy may be revoked at any time before it is exercised by delivering a
written notice of revocation to the Secretary of the Company.  If you attend the
Annual  Meeting in person,  you may revoke your proxy by either giving notice of
revocation to the  inspectors of election at the Annual  Meeting or by voting at
the Annual Meeting in person.

     The only items of business  that the Board of Directors  intends to present
or knows will be presented at the Annual Meeting are the items discussed in this
Proxy  Statement.  The proxy confers  discretionary  authority  upon the persons
named therein, or their substitutes, to vote on any other items of business that
may properly come before the meeting.

     Only  stockholders  of record at the close of business on May 14, 1997, the
record date for the Annual Meeting (the "Record  Date"),  are entitled to notice
of and to vote at the Annual  Meeting.  As of the Record  Date the  Company  had
7,971,802  shares of Common Stock,  par value $.01 per share  ("Common  Stock"),
issued  and  outstanding.  Each  share is  entitled  to one vote on each  matter
submitted  to a vote  at the  Annual  Meeting.  A  majority  of the  issued  and
outstanding shares constitutes a quorum at the meeting.

                                VOTING PROCEDURES

     The directors will be elected by the affirmative  vote of a majority of the
shares of Common Stock present in person or  represented  by proxy at the Annual
Meeting,  provided a quorum exists. A quorum is established if, as of the Record
Date, at least a majority of the outstanding  shares of Common Stock are present
in person or represented by proxy at the Annual  Meeting.  The  ratification  of
Deloitte & Touche LLP as auditors and all other matters at the meeting will also
be decided by the  affirmative  vote of a majority of the shares of Common Stock
cast with respect thereto,  provided a quorum exists.  Votes will be counted and

<PAGE>

certified by one or more Inspectors of Election who are expected to be employees
of the Company or  Continental  Stock  Transfer & Trust  Company,  the Company's
stock transfer agent.  In accordance with Delaware law,  abstentions and "broker
non-votes" (i.e.  proxies from brokers or nominees  indicating that such persons
have not  received  instructions  from  the  beneficial  owner or other  persons
entitled  to vote  shares as to a matter  with  respect to which the  brokers or
nominees do not have discretionary power to vote) will be treated as present for
purposes of  determining  the presence of a quorum.  For purposes of determining
approval  of a matter  presented  at the  meeting,  abstentions  will be  deemed
present and entitled to vote and will, therefore,  have the same legal effect as
a vote  "against" a matter  presented at the meeting.  Broker  non-votes will be
deemed not  entitled to vote on the subject  matter as to which the  non-vote is
indicated  and  will,  therefore,  have  no  legal  effect  on the  vote on that
particular matter. Each stockholder may revoke a previously granted proxy at any
time before it is exercised by filing with the Secretary of the Company either a
notice of revocation or a duly executed  proxy bearing a later date.  The powers
of the proxy holders will be suspended if the person executing the proxy attends
the meeting in person and so  requests.  Attendance  at the meeting will not, in
itself, constitute revocation of a previously granted proxy.

                      VOTING SECURITY OWNERSHIP OF CERTAIN
                        BENEFICIAL OWNERS AND MANAGEMENT

     The following table sets forth certain information regarding the beneficial
ownership of the shares of the Company's Common Stock as of May 14, 1997, (i) by
each person the Company  knows to be the  beneficial  owner of 5% or more of the
outstanding  shares of Common Stock, (ii) each named executive officer listed in
the Summary  Compensation Table, (iii) each director of the Company and (iv) all
executive officers and directors of the Company as a group.

                                                     Shares         Percentage
                                                  Beneficially     Beneficially
           Beneficial Owner (1)                       Owned            Owned
           --------------------                    ----------       ----------
Derace L. Schaffer (2)...........................   1,711,700          21.5%
John Pappajohn (3)...............................   1,449,680          18.2%
Edgewater Private Equity Fund II, L.P. ..........     970,000          12.2%
   666 Grand Avenue, Suite 200
   Des Moines, IA 50309
Donald A. Carlberg (4)...........................     104,400           1.3%
Gregory D. Brown (5).............................      40,320             *
James D. Turner (6)..............................        --               *
Kent A. Tapper (7)...............................       7,300             *
Barbara J. McNeil (8)............................      14,400             *
Carl F. Kohrt (7)................................       7,200             *
All directors and executive officers as a group
  (8 persons)(9).................................   3,335,000          40.9%

- ----------
*    Less than one percent.
(1)  Unless  otherwise  noted,  the address of each of the listed persons is c/o
     the Company at 46 Prince Street, Rochester, New York 14607.
(2)  Includes  288,000  shares  held  by Dr.  Schaffer's  minor  children.  Also
     includes  7,200 shares which are issuable upon the exercise of options that
     are either currently exercisable or which become exercisable within 60 days
     of May 14, 1997.  Does not include  28,800  shares  subject to  outstanding
     options which are not exercisable within 60 days of May 14, 1997.


                                       2
<PAGE>

(3)  Includes 360,000 shares held by Halkis,  Ltd., a sole proprietorship  owned
     by  Mr.   Pappajohn,   360,000   shares  held  by  Thebes,   Ltd.,  a  sole
     proprietorship  owned by Mr.  Pappajohn's  spouse and  360,000  shares held
     directly by Mr.  Pappajohn's  spouse.  Mr. Pappajohn  disclaims  beneficial
     ownership of the shares owned by Thebes,  Ltd. and by his spouse.  Includes
     options to purchase 7,200 shares which are either currently  exercisable or
     which become  exercisable  within 60 days of May 14, 1997. Does not include
     28,800 shares  subject to  outstanding  options  which are not  exercisable
     within 60 days of May 14, 1997.
(4)  Represents  options to purchase  104,400 shares which are either  currently
     exercisable  or which  become  exercisable  within 60 days of May 14, 1997.
     Does not include  129,600 shares  subject to outstanding  options which are
     not exercisable within 60 days of May 14, 1997.
(5)  Includes  options to  purchase  34,560  shares  which are either  currently
     exercisable  or which  become  exercisable  within 60 days of May 14, 1997.
     Does not include 66,240 shares subject to outstanding options which are not
     exercisable within 60 days of May 14, 1997.
(6)  Does not include 72,000 shares subject to outstanding options which are not
     exercisable within 60 days of May 14, 1997.
(7)  Includes  options to  purchase  7,200  shares  which are  either  currently
     exercisable  or which  become  exercisable  within 60 days of May 14, 1997.
     Does not include 28,800 shares subject to outstanding options which are not
     exercisable within 60 days of May 14, 1997.
(8)  Includes  options to  purchase  14,400  shares  which are either  currently
     exercisable  or which  become  exercisable  within 60 days of May 14, 1997.
     Does not include 21,600 shares subject to outstanding options which are not
     exercisable within 60 days of May 14, 1997.
(9)  Includes  options to purchase  182,160  shares  which are either  currently
     exercisable  or which  become  exercisable  within 60 days of May 14, 1997.
     Does not include 404,640 shares subject to outstanding options and warrants
     which are not exercisable within 60 days of May 14, 1997.

                                   PROPOSAL 1
                              ELECTION OF DIRECTORS

     At this year's  Annual  Meeting of  Stockholders,  five  directors  will be
elected  to hold  office  for a term  expiring  at the next  Annual  Meeting  of
Stockholders.  Each  director  will be elected  to serve  until a  successor  is
elected and qualified or until the director's earlier resignation or removal.

     Proxies  granted  by  stockholders  will  be  voted  individually  for  the
election,  as directors of the Company,  of the persons  listed below,  unless a
proxy  specifies  that it is not to be voted in favor of a nominee for director.
In the event any of the nominees  listed  below shall be unable to serve,  it is
intended that the proxy will be voted for such other  nominees as are designated
by the Board of Directors.  Each of the persons named below has indicated to the
Board of Directors of the Company that they are available to serve.

     The names, ages, principal occupations and other information concerning the
director  nominees,  based upon  information  received from them,  are set forth
below.

     Derace L.  Schaffer,  M.D.,  48 (Chairman  of the Board of Directors  since
1995).  Dr.  Schaffer has been the President of The Ide Group,  P.C., a group of
physicians  providing  radiological  services at multiple  locations in New York
State, since 1980, and since 1990 he has also been President of The Lan Group, a
venture  capital firm  specializing in health care  investments.  He serves as a
Clinical  Professor  at the  University  of  Rochester  School of Medicine and a
Director of American Physician Partners,  Inc., Medifax, Inc., NeuralMed,  Inc.,
NeuralTech,  Inc., Oncor, Inc., Preferred Oncology Networks of America, Inc. and
The Care Group, Inc. as well as several not-for-profit corporations.

     Donald A.  Carlberg,  45  (Director  since  1995).  Mr.  Carlberg  has been
President,  Chief  Executive  Officer and a Director  of the  Company  since its
inception in February  1995.  From February  1993 to December 1994 Mr.  Carlberg
served as Chief Executive Officer of Patient  Management  Technologies,  Inc., a


                                       3
<PAGE>

medical services  consulting  company,  which he founded.  From 1992 to 1994 Mr.
Carlberg  served as Senior Vice  President,  Sales and Marketing for  Neurocare,
Inc./Paradigm  Health Corp. From 1990 to 1992 Mr. Carlberg served as Director of
Managed Care for Baxter Healthcare  International  where he started managed care
initiatives  for its  Caremark  Division.  From 1985 to 1990 Mr.  Carlberg  held
several  senior level  positions in managed  care at Blue  Cross/Blue  Shield of
Rochester, New York and Independence Blue Cross in Philadelphia, Pennsylvania.

     Carl F. Kohrt, Ph.D., 53 (Director since 1996). Dr. Kohrt is Executive Vice
President and Assistant  Chief  Operating  Officer of the Eastman Kodak Company,
where he has served in various  capacities  since 1971. Dr. Kohrt is a recipient
of a Sloan Fellowship for study at Massachusetts Institute of Technology.

     Barbara J. McNeil,  M.D.,  Ph.D., 56 (Director  since 1995).  Dr. McNeil is
Head of the  Department  of Health Care Policy and a Professor  of  Radiology at
Harvard  Medical School where she has served in various  capacities  since 1971.
For four years she has served as Chair of the Blue Cross Massachusetts  Hospital
Association Fund for Cooperative Innovation and currently she is a member of the
National Council on Radiation Protection,  the American College of Radiology and
its Board of Chancellors,  the Society of Nuclear Medicine, the Advisory Council
for the Agency for Health Care Policy and Research  and the National  Academy of
Sciences'  Institute of Medicine where she is a Council member.  She also serves
as a Director of CV Therapeutics, Inc.

     John Pappajohn.  68 (Director since 1995).  Mr. Pappajohn has been the sole
owner of Pappajohn  Capital  Resources,  a venture capital firm  specializing in
health care  investments,  and President of Equity  Dynamics,  Inc., a financial
consulting  firm, both located in Des Moines,  Iowa,  since 1969. He serves as a
Director for the following public companies: CORE, Inc., Drug Screening Systems,
Inc., Fuisz Technologies, Ltd., GalaGen, Inc., HealthDesk Corporation, OncorMed,
Inc., Pace Health Management Systems, Inc. and The Care Group, Inc.

     During  the 1996  fiscal  year  there  were four  meetings  of the Board of
Directors.  Each Director attended at least 75% of the aggregate total number of
the meetings of the Board of Directors held during the year,  with the exception
of Dr. Kohrt who attended 67% of the meetings held subsequent to his election to
the Board of Directors.

     The Board of Directors  has  standing  Audit and  Compensation  Committees,
which deal with certain specific areas of the Board's responsibility.

     The  Audit  Committee,  which did not meet  during  the 1996  fiscal  year,
recommends the firm to be appointed as independent  public  accountants to audit
the  Company's  financial  statements  and  reviews the scope and results of the
audit  and  other  services  provided  by  the  Company's   independent   public
accountants.  The members of the Audit Committee are Mr. Pappajohn,  Dr. McNeil,
and Dr. Kohrt.

     The Compensation Committee, which did not meet during the 1996 fiscal year,
develops  the  Company's  executive  compensation  philosophy  and  reviews  and
recommends  the  compensation  programs for  officers of the Company,  including
salaries and incentive compensation. The Compensation Committee also administers
the  Company's  Employee  Stock  Option  Plan.  The members of the  Compensation
Committee are Dr. Schaffer, Dr. McNeil and Dr. Kohrt.

     Directors  who are not  currently  receiving  compensation  as  officers or
employees of the Company are entitled to reimbursement of expenses for attending
each meeting of the Board of Directors and each meeting of any committee.


                                       4
<PAGE>

     The  Company's  directors  are  eligible to  participate  in the  Company's
Employee  Stock  Option  Plan.  Pursuant  to the  Employee  Stock  Option  Plan,
non-employee   directors  of  the  Company   receive  a  one-time   grant  of  a
non-qualified  stock option to purchase  36,000 shares of the  Company's  Common
Stock at an exercise  price equal to fair market  value per share on the date of
their initial election to the Company's Board of Directors.  Such  non-qualified
stock option vests as to 20% of the option grant on the first anniversary of the
grant,  and 20% on each subsequent  anniversary,  is exercisable only during the
non-employee  director's  term  and  automatically  expires  on  the  date  such
director's service  terminates.  Upon the occurrence of a change of control,  as
defined in the Employee  Stock Option Plan,  all  outstanding  unvested  options
immediately vest.

     Section  16(a) of the Exchange Act requires  that the  Company's  executive
officers and directors,  and  beneficial  owners of 10% or more of the Company's
stock file  initial  reports of ownership  and of changes of ownership  with the
Securities  and  Exchange  Commission  and the NASDAQ  Stock  Market.  Executive
officers,  directors  and 10%  beneficial  owners  are  required  by  securities
regulations  to furnish the Company with copies of all Section  16(a) forms they
file.

     Based on a review of the copies of reports  furnished to the  Company,  the
Company  believes  that  during  the year  ended  December  31,  1996 all filing
requirements  applicable to its officers,  directors and ten percent  beneficial
owners were met, except that initial  reports of beneficial  ownership on Form 3
were filed late.

                             EXECUTIVE COMPENSATION

     The  following  table  sets forth the  compensation  paid or accrued by the
Company for services  rendered in all capacities  for executive  officers of the
Company who received  compensation  in excess of $100,000 during the period from
inception on February 22, 1995 to December 31, 1995 and during 1996.

                           Summary Compensation Table
<TABLE>
<CAPTION>

                                                                                      
                                                                                       Long-Term 
                                                                                     Compensation
                                                  Annual Compensation                   Awards   
                                                  -------------------                 Securities
    Name and Principal Position          Year           Salary          Bonus     Underlying Options (#)
    ---------------------------          ----           ------          -----     ----------------------
<S>                                       <C>           <C>             <C>               <C>   
Donald A. Carlberg, President             1996          $131,731        $25,000           18,000
  and Chief Executive Officer             1995(1)       $ 96,417        $15,000          216,000

Gregory D. Brown, Sr. Vice                1996          $103,077        $20,000           10,800
  President, Chief Financial Officer,     1995(1)       $ 60,034        $     0           90,000
  Secretary and Treasurer

Giancarla C. Miele, Vice President        1996          $103,077        $ 5,000           36,000
  of Operations (2)                       1995(1)       $ 16,912        $     0           36,000

George T. Witter, Vice President          1996          $119,062        $12,500           18,000
  of Sales (3)                            1995(1)       $ 49,512        $     0           54,000
</TABLE>

- ----------
(1)  Reflects  compensation paid from inception on February 22, 1995 to December
     31, 1995.
(2)  Ms.  Miele  resigned her position as Vice  President  of  Operations  as of
     February 7, 1997.
(3)  Mr. Witter  resigned his position as Vice President of Sales as of November
     1, 1996.


                                       5
<PAGE>

     The  following  table  sets forth  certain  information  regarding  options
granted to the Chief  Executive  Officer  and other  executive  officers  of the
Company during 1996.

                            Option Grants During 1996
<TABLE>
<CAPTION>

                                                Individual Grants
                                                -----------------
                                                                                        Potential Realizable Value
                                                                                          at Assumed Annual Rates
                                 Number of    % of Total Options                        of Stock Price Appreciation
                                Securities        Granted to       Exercise                 for Option Term (2)
                            Underlying Options   Employees in       Price    Expiration    -------------------
        Name                  Granted (#)(1)      Fiscal Year      $/Share      Date        5% ($)      10% ($)
        ----                   ------------      ------------       ------    --------     -------      ------
<S>                               <C>                <C>           <C>        <C>           <C>        <C>       
Donald A. Carlberg........        18,000             4.9%           $2.08      4/08/06      $ 23,546   $   59,670
Gregory D. Brown..........        10,800             3.0%           $2.08      4/08/06        14,127       35,802
James D. Turner...........        72,000            19.7%          $10.00     11/22/06       452,804    1,147,495
George T. Witter..........        18,000             4.9%           $2.08      4/08/06        23,546       59,670
Giancarla C. Miele........        36,000             9.9%           $2.08      4/08/06        47,092      119,340
</TABLE>                                                                   

- ----------
(1)  All options  will become  exercisable  at the rate of 20% per year from the
     date of grant and have ten year terms as long as the optionee's  employment
     with the Company  continues.  The exercise price of each option is equal to
     the fair market  value of the  underlying  Common  Stock on the date of the
     grant, as determined by the Board of Directors.
(2)  Future  value of current  year grants  assumes  appreciation  in the market
     value of the Common Stock of 5% and 10% per year over the  ten-year  option
     period as required by the rules of the Securities  and Exchange  Commission
     and do not represent the Company's estimate or projection of actual values.
     The actual value  realized  may be greater than or less than the  potential
     realizable values set forth in the table.

     No stock  options were  exercised by the Chief  Executive  Officer or other
executive  officers of the Company during 1996.  The following  table sets forth
certain  information  regarding  unexercised options held by the Chief Executive
Officer and other executive officers of the Company at December 31, 1996.

                       Option Values on December 31, 1996
<TABLE>
<CAPTION>

                                           Number of Securities Underlying         Value of Unexercised
                                               Unexercised Options at             In-the-Money Options at
                                                December 31, 1996(#)              December 31, 1996($)(1)
                                            -----------------------------      -----------------------------
       Name                                 Exercisable     Unexercisable      Exercisable     Unexercisable
       ----                                 -----------     -------------      -----------     -------------
<S>                                           <C>               <C>              <C>             <C>       
Donald A. Carlberg.....................       72,000            162,000          $651,960        $1,425,060
Gregory D. Brown.......................       18,000             82,800           162,000           725,436
James D. Turner........................            0             72,000                 0                 0
Kent A. Tapper.........................        7,200             28,800            65,592           262,368
Giancarla C. Miele.....................        7,200             64,800            59,112           494,568
</TABLE>

- ----------
(1)  Calculated based upon $9.25 market value of the underlying securities as of
     December 31, 1996.


                                       6
<PAGE>

                      REPORT OF THE COMPENSATION COMMITTEE
                            OF THE BOARD OF DIRECTORS

     Because the Company  completed its public offering in late December 1996 no
formal compensation committee meetings have yet been held.  Compensation for the
Company's  executive  officers was determined by the Board of Directors in light
of  the   responsibilities   involved  in  commencing  the  Company's   business
operations,  developing its initial customer  relationships and negotiating with
the Company's investment bankers.

     The  Compensation  Committee  intends to evaluate the  performance  of each
executive officer of the Company in the context of the goals and challenges that
the Company faces over the next year.  Because of the  Company's  early stage of
development,  the Committee will consider  factors other than  profitability  in
determining compensation for the next year.

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

     The Company was initially capitalized on February 22, 1995 through the sale
of 3,600,000  shares of its Common Stock for $.14 per share.  Included among the
participants in that  transaction  were Dr. Derace L. Schaffer,  Chairman of the
Board,  who purchased  1,656,000  shares,  Dr.  Schaffer's  spouse who purchased
144,000 shares, John Pappajohn, a director, who purchased 541,800 shares, a sole
proprietorship  owned by Mr.  Pappajohn  which  purchased  360,000  shares,  Mr.
Pappajohn's  spouse,  who purchased  360,000 shares,  and a sole  proprietorship
owned by Mr. Pappajohn's spouse which purchased 360,000 shares.

     In August and  September of 1995 the Company sold  1,800,000  shares of its
Series A Preferred  Stock in a private  placement for $1.00 per share.  Included
among the  participants  in that  transaction  were  Gregory D. Brown,  Sr. Vice
President,  Chief  Financial  Officer,  Secretary and  Treasurer,  who purchased
10,000  shares and Mr.  Pappajohn  who  purchased  10,000  shares.  In addition,
Edgewater Private Equity Fund II, L.P.,  ("Edgewater"),  a five percent owner of
the  Common  Stock  of the  Company,  acquired  1,000,000  shares  of  Series  A
Convertible  Preferred  Stock  in  the  Series  A  Convertible  Preferred  Stock
offering.  On December 26, 1996,  each share of Series A  Convertible  Preferred
Stock was converted into .72 shares of the Company's Common Stock.

     In May and June of 1996,  the Company sold  600,000  shares of its Series B
Convertible Preferred Stock in a private placement for $5.00 per share. Included
among the  participants in that  transaction  were Dr.  Schaffer,  who purchased
20,000 shares,  Mr.  Pappajohn,  who purchased 40,000 shares and Edgewater which
purchased  200,000  shares.  On  December  26,  1996,  each  share  of  Series B
Convertible Preferred Stock has been converted into 1.25 shares of the Company's
Common Stock.


                                       7
<PAGE>

                            COMPANY PERFORMANCE GRAPH

     The following graph compares the cumulative total stockholder return on the
Common Stock of Patient  Infosystems,  Inc. from December 19, 1996 (the date the
Common Stock was first offered to the public at an initial public offering price
of $8.00 per share) through  December 31, 1996 with the cumulative  total return
on the NASDAQ Stock Market - U.S. Index and the  cumulative  total return on the
NASDAQ Health Services Index.  The Company did not pay any dividends during this
period.  The NASDAQ Stock  Market - U.S.  Index and the NASDAQ  Health  Services
Index are  published  daily.  The graph assumes an investment of $100 in each of
Patient  Infosystems,  Inc., the NASDAQ Stock Market - U.S. Index and the NASDAQ
Health Services Index on December 19, 1996. The Comparison also assumes that all
dividends are  reinvested.  It should be noted that the  Company's  Common Stock
traded for only an insignificant period of time during 1996.

                      COMPARISON OF CUMULATIVE TOTAL RETURN
                AMONG PATIENT INFOSYSTEMS, INC., THE NASDAQ STOCK
            MARKET - U.S. INDEX AND THE NASDAQ HEALTH SERVICES INDEX

  [The following table is represented as a line chart in the printed material]

                                         December 19, 1996    December 31, 1996
                                         ----------------     ----------------
Patient Infosystems, Inc................       100.00              115.63
NASDAQ Stock Market - U.S. Index........       100.00               99.49
NASDAQ Health Services Index............       100.00              100.55

     The  comparisons  in this table are required by the rules of the Securities
and Exchange  Commission  and are not intended to forecast or be  indicative  of
possible  future  performance  of the Company's  Common  Stock.  The stock price
performance  graph shall not be deemed to be incorporated  into any filing under
the Securities Act or the Exchange Act,  notwithstanding  any general  statement
contained in any such filing  incorporating  this Proxy  Statement by reference,
except to the extent that the Company specifically incorporates this information
by reference.


                                       8
<PAGE>

                                   PROPOSAL 2
                         RATIFICATION OF APPOINTMENT OF
                              INDEPENDENT AUDITORS

     The independent  public  accounting firm utilized by the Company during the
fiscal  years  ended  December  31,  1995 and 1996 was  Deloitte  & Touche  LLP,
independent  certified public accountants.  Although the appointment of auditors
is not  required  to be  submitted  to a vote  of  stockholders,  the  Board  of
Directors  believes that it is appropriate as a matter of policy to request that
the stockholders  ratify the appointment.  If the stockholders should not ratify
the  appointment,  the Audit  Committee  will  investigate  the  reasons for the
stockholders'   rejection  and  the  Board  of  Directors  will  reconsider  the
appointment.  It is expected that a representative of Deloitte & Touche LLP will
be present at the meeting.

     The Board of Directors  unanimously  recommends that the stockholders  vote
FOR  ratification  of the  appointment of Deloitte & Touche LLP as the Company's
independent auditors.

                  STOCKHOLDER PROPOSALS FOR 1998 ANNUAL MEETING

     Stockholders who wish to present proposals appropriate for consideration at
the Company's  1998 Annual Meeting of  Stockholders  must submit the proposal in
proper  form to the  Company at its  address set forth on the first page of this
Proxy  Statement not later than January 17, 1998 in order for the proposition to
be considered for inclusion in the Company's  proxy  statement and form of proxy
relating to such annual meeting.  Any such  proposals,  as well as any questions
related thereto, should be directed to the Secretary of the Company.

                             ADDITIONAL INFORMATION

     The expenses in connection  with the  solicitation of proxies will be borne
by the  Company.  Solicitation  will be made by  mail,  but may  also be made by
telephone or personal  call by  officers,  directors or employees of the Company
who will not be specially  compensated  for such  solicitation.  The Company may
request that brokerage  houses and other nominees or fiduciaries  forward copies
of the Company's Proxy Statement and Annual Report to Stockholders to beneficial
owners of stock held in their  names,  and the  Company may  reimburse  them for
reasonable out-of-pocket expenses incurred in doing so.

     A COPY OF THE COMPANY'S  ANNUAL REPORT FOR THE YEAR ENDED DECEMBER 31, 1996
IS BEING  FURNISHED  HEREWITH TO EACH  STOCKHOLDER  OF RECORD AS OF THE CLOSE OF
BUSINESS ON MAY 14, 1997.  COPIES OF THE  COMPANY'S  ANNUAL  REPORT ON FORM 10-K
WILL BE PROVIDED FOR A NOMINAL CHARGE UPON WRITTEN REQUEST TO:

                            PATIENT INFOSYSTEMS, INC.
                                46 Prince Street
                            Rochester, New York 14607
                           Attention: Gregory D. Brown

                                       By Order of the Board of Directors,

                                                GREGORY D. BROWN
                                                Secretary


                                       9
<PAGE>

PROXY                       PATIENT INFOSYSTEMS, INC.                      PROXY
                 (Solicited on behalf of the Board of Directors)

     The  undersigned  holder  of Common  Stock of  Patient  Infosystems,  Inc.,
revoking all proxies heretofore given, hereby constitutes and appoints Donald A.
Carlberg and Derace L. Schaffer,  and each of them, Proxies,  with full power of
substitution,  for the  undersigned  and in the  name,  place  and  stead of the
undersigned, to vote all of the undersigned's shares of said stock, according to
the  number of votes and with all the powers the  undersigned  would  possess if
personally  present,  at the 1997  Annual  Meeting  of  Shareholders  of Patient
Infosystems,  Inc.,  to be held in the Baush and Lomb Parlor of the Memorial Art
Gallery,  500  University  Avenue,  Rochester,  NY 14607 at 10:00  a.m.  Eastern
Daylight Time, and at any adjournments or postponements thereof.

     Each  properly  executed  Proxy  will  be  voted  in  accordance  with  the
specifications  made on this Proxy and in the  discretion  of the Proxies on any
other  matter  that may  properly  come before the  meeting.  Where no choice is
specified,  this  Proxy will be voted (i) FOR all  listed  nominees  to serve as
directors,  and (ii) FOR the  ratification  and approval of the  appointment  of
Deloitte & Touche, LLP as the Company's independent auditors for the fiscal year
ending December 31, 1997, and in accordance with their  discretion on such other
matters as may properly come before the meeting.

  1. ELECTION OF FIVE DIRECTORS     [ ] FOR all nominees listed 
                                           (except as marked to the contrary)
                                    [ ] WITHHOLD AUTHORITY to vote for all below

    Nominees: Dr. Derace L. Schaffer, Donald A. Carlberg, Dr. Carl F. Kohrt,
                     Dr. Barbara J. McNeil, John Pappajohn

    (Instruction: To withhold authority to vote for any individual nominees,
            circle that nominee's name in the list provided above.)


<PAGE>

     2. The  ratification  and approval of the appointment of Deloitte & Touche,
LLP as the Company's  independent  auditors for the fiscal year ending  December
31, 1997.

  [ ] FOR                      [ ] AGAINST                   [ ] ABSTAIN

     3. The proxies are authorized to vote in their  discretion  upon such other
matters as may properly come before the meeting.

                                       Dated ____________________________, 1997

                                       ________________________________________

                                       ________________________________________
                                                      Signature(s)

                                       (Signature(s)  should  conform  to actual
                                       number  registered.   For  jointly  owned
                                       shares,  each  owner  should  sign.  When
                                       signing    as     attorney,     executor,
                                       administrator,   trustee,   guardian   or
                                       officer  of a  corporation,  please  give
                                       full title.)



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